subject area of

• A THEMIS:SHP1 complex promotes T-cell survival  Academic Article
• A chemical approach for detecting sulfenic acid-modified proteins in living cells  Academic Article
• A conserved motif in the itk ph-domain is required for phosphoinositide binding and tcr signaling but dispensable for adaptor protein interactions  Academic Article
• A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing  Academic Article
• A small molecule inhibitor of α4 integrin-dependent cell migration  Academic Article
• Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells  Academic Article
• Altered DNA methylation in leukocytes with trisomy 21  Academic Article
• Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase  Academic Article
• An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription  Academic Article
• An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activation  Academic Article
• An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory response  Academic Article
• Application of microdroplet pcr for large-scale targeted bisulfite sequencing  Academic Article
• BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment  Academic Article
• Binding of recombinant feline immunodeficiency virus surface glycoprotein to feline cells: Role of cxcr4, cell-surface heparans, and an unidentified non-cxcr4 receptor  Academic Article
• Bioorthogonal chemical reporters for monitoring protein acetylation  Academic Article
• Bridging the NFAT and NF-kappa B families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress  Academic Article
• Cellular internalization and targeting of semiconductor quantum dots  Academic Article
• Characterization of an HIV-targeted transcriptional gene-silencing RNA in primary cells  Academic Article
• Chemically programmed bispecific antibodies that recruit and activate T cells  Academic Article
• Coaxial flow mixer for real-time monitoring of cellular responses in flow injection cytometry  Academic Article
• Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor  Academic Article
• Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3  Academic Article
• Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta  Academic Article
• Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group  Academic Article
• Detection of protein S-sulfhydration by a tag-switch technique  Academic Article
• Discovery and characterization of an endogenous CXCR4 antagonist  Academic Article
• Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha(3)beta-tetrapeptides  Academic Article
• Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes  Academic Article
• Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation  Academic Article
• Effect of lysine methylation and acetylation on the RNA recognition and cellular uptake of Tat-derived peptides  Academic Article
• Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain  Academic Article
• Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions  Academic Article
• Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues  Academic Article
• Fine specificity of tcr complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a cd1-lipid complex  Academic Article
• Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication  Academic Article
• Global landscape of HIV-human protein complexes  Academic Article
• Global mapping of the topography and magnitude of proteolytic events in apoptosis  Academic Article
• Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores  Academic Article
• Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins b cell linker protein and slp-76 in lymphocytes  Academic Article
• Histidine-rich glycoprotein binds to DNA and Fc gamma RI and potentiates the ingestion of apoptotic cells by macrophages  Academic Article
• Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity  Academic Article
• Identification of siglec-9 as the receptor for muc16 on human nk cells, b cells, and monocytes  Academic Article
• Identification of the low density lipoprotein (ldl) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris  Academic Article
• Immunosuppressive effects of glucosamine  Academic Article
• Influencing uptake and localization of aminoglycoside-functionalized peptoids  Academic Article
• Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent  Academic Article
• Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion  Academic Article
• Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system  Academic Article
• Inhibitors of cell migration that inhibit intracellular paxillin/alpha a binding: A well-documented use of positional scanning libraries  Academic Article
• K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling  Academic Article
• Labeling live cells by copper-catalyzed alkyne-azide click chemistry  Academic Article
• Large-scale profiling of protein palmitoylation in mammalian cells  Academic Article
• Lipid- and polyion complex-based micelles as agonist platforms for TNFR superfamily receptors  Academic Article
• Lymphoproliferative disease and autoimmunity in mice with increased mir-17-92 expression in lymphocytes  Academic Article
• Metabolic labeling of sialic acids in living animals with alkynyl sugars  Academic Article
• Monitoring dynamic glycosylation in vivo using supersensitive click chemistry  Academic Article
• Multiformat T-cell-engaging bispecific antibodies targeting human breast cancers  Academic Article
• Multivalent scaffold proteins as superagonists of TRAIL receptor 2-induced apoptosis  Academic Article
• N-(3-phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists  Academic Article
• Negative regulation of t cell receptor signaling by siglec-7 (p70/airm) and siglec-9  Academic Article
• Non-degradative ubiquitination of protein kinases  Academic Article
• Noncanonical NF-kappa B signaling is limited by classical NF-kappa B activity  Academic Article
• Nuclear export of NF90 is required for interleukin-2 mRNA stabilization  Academic Article
• On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7  Academic Article
• P21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized RHO exchange factor  Academic Article
• PNA-encoded protease substrate microarrays  Academic Article
• Peroxidation and externalization of phosphatidylserine associated with release of cytochrome c from mitochondria  Academic Article
• Presentation of chemokine SDF-1α by fibronectin mediates directed migration of T cells  Academic Article
• Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry  Academic Article
• Profiling protein function with small molecule microarrays  Academic Article
• Protein carbamylation links inflammation, smoking, uremia and atherogenesis  Academic Article
• Protein kinase C-eta controls CTLA-4-mediated regulatory T cell function  Academic Article
• Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants  Academic Article
• Proteomic analysis of human immunodeficency virus using liquid chromatography/tandem mass spectrometry effectively distinguishes specific incorporated host proteins  Academic Article
• Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry  Academic Article
• Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation  Academic Article
• Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase  Academic Article
• Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases  Academic Article
• Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling  Academic Article
• Regulation of tyrosine phosphorylation in isolated t cell membrane by inhibition of protein tyrosine phosphatases  Academic Article
• Replication and neutralization of human immunodeficiency virus type 1 lacking the v1 and v2 variable loops of the gp120 envelope glycoprotein  Academic Article
• SIRT1 negatively regulates the mammalian target of rapamycin  Academic Article
• STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells  Academic Article
• Shp2 is a target of the immunosuppressant tautomycetin  Academic Article
• Small nucleolar rnp scleroderma autoantigens associate with phosphorylated serine/arginine splicing factors during apoptosis  Academic Article
• Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab  Academic Article
• Sulfated ligands for the copper(I)-catalyzed azide-alkyne cycloaddition  Academic Article
• Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor  Academic Article
• T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component  Academic Article
• T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements  Academic Article
• TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmission by human langerhans cells ex vivo  Academic Article
• Targeting of t lymphocytes to melanoma cells through chimeric anti-gd3 immunoglobulin t-cell receptors  Academic Article
• Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN  Academic Article
• Temperature-dependent STIM1 activation induces Ca(2+) influx and modulates gene expression  Academic Article
• The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR  Academic Article
• The small gtpase cdc42 initiates an apoptotic signaling pathway in jurkat t lymphocytes  Academic Article
• The triggering receptor expressed on myeloid cells 2 binds apolipoprotein E  Academic Article
• The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis  Academic Article
• Thioredoxin is required for s-nitrosation of procaspase-3 and the inhibition of apoptosis in jurkat cells  Academic Article
• Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus  Academic Article
• Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue, and West Nile viruses  Academic Article
• Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase  Academic Article