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src-Family Kinases

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  • A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors  Academic Article
  • A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function  Academic Article
  • A discovery strategy for selective inhibitors of c-Src in complex with the focal adhesion kinase SH3/SH2-binding region  Academic Article
  • A minor catalytic activity of src family kinases is sufficient for maximal activation of mast cells via the high-affinity ige receptor  Academic Article
  • A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1β  Academic Article
  • A phosphoarginine containing peptide as an artificial SH2 ligand  Academic Article
  • A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus  Academic Article
  • Activation of macrophage CD8: pharmacological studies of TNF and IL-1 beta production  Academic Article
  • Activation of mitogen-activated protein kinases and p90 ribosomal s6 kinase in failing human hearts with dilated cardiomyopathy  Academic Article
  • Apolipoprotein E receptor 2 mediates activated protein C-induced endothelial Akt activation and endothelial barrier stabilization  Academic Article
  • Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1  Academic Article
  • Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells  Academic Article
  • Ceramide mediates the rapid phase of febrile response to IL-1β  Academic Article
  • Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow  Academic Article
  • Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors  Academic Article
  • Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase  Academic Article
  • EphA2 and Src regulate equatorial cell morphogenesis during lens development  Academic Article
  • Gene therapy for arthritis  Academic Article
  • Growth factor activity of endothelin-1 in primary astrocytes mediated by adhesion-dependent and -independent pathways  Academic Article
  • Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening  Academic Article
  • Integrin alpha beta 1, alpha(v)beta, alpha(6)beta effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance  Academic Article
  • Interleukin-1 beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases  Academic Article
  • Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin alpha v beta 5: implications for angiogenesis in human obesity  Academic Article
  • Molecular design and biological-activity of potent and selective protein-kinase inhibitors related to balanol  Academic Article
  • MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics  Academic Article
  • Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells  Academic Article
  • Perspective on computational and structural aspects of kinase discovery from IPK2014  Academic Article
  • Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling  Academic Article
  • Proteolysis-induced n-terminal ectodomain shedding of the integral membrane glycoprotein cub domain-containing protein 1 (cdcp1) is accompanied by tyrosine phosphorylation of its c-terminal domain and recruitment of src and pkc delta  Academic Article
  • Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progession  Academic Article
  • Reduced glioma infiltration in Src-deficient mice  Academic Article
  • Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif  Academic Article
  • Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits  Academic Article
  • SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent  Academic Article
  • Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma  Academic Article
  • Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a beta-arrestin2/Src/Akt signaling complex in vivo  Academic Article
  • Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells  Academic Article
  • Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors  Academic Article
  • Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity  Academic Article
  • Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas  Academic Article
  • Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: the role of sphingosine 1-phosphate receptor-4  Academic Article
  • Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor  Academic Article
  • Src and multiple map kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: Comparison with acute mechanical stretch  Academic Article
  • Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction  Academic Article
  • Src family kinase and adenosine differentially regulate multiple map kinases in ischemic myocardium: Modulation of map kinases activation by ischernic preconditioning  Academic Article
  • TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching  Academic Article
  • The cell surface glycoprotein CDCP1 in cancer: insights, opportunities, and challenges  Academic Article

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