subject area of

• A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors  Academic Article
• A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function  Academic Article
• A discovery strategy for selective inhibitors of c-Src in complex with the focal adhesion kinase SH3/SH2-binding region  Academic Article
• A minor catalytic activity of src family kinases is sufficient for maximal activation of mast cells via the high-affinity ige receptor  Academic Article
• A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1β  Academic Article
• A phosphoarginine containing peptide as an artificial SH2 ligand  Academic Article
• A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus  Academic Article
• Activation of macrophage CD8: pharmacological studies of TNF and IL-1 beta production  Academic Article
• Activation of mitogen-activated protein kinases and p90 ribosomal s6 kinase in failing human hearts with dilated cardiomyopathy  Academic Article
• Apolipoprotein E receptor 2 mediates activated protein C-induced endothelial Akt activation and endothelial barrier stabilization  Academic Article
• Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1  Academic Article
• Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells  Academic Article
• Ceramide mediates the rapid phase of febrile response to IL-1β  Academic Article
• Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow  Academic Article
• Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors  Academic Article
• Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase  Academic Article
• EphA2 and Src regulate equatorial cell morphogenesis during lens development  Academic Article
• Gene therapy for arthritis  Academic Article
• Growth factor activity of endothelin-1 in primary astrocytes mediated by adhesion-dependent and -independent pathways  Academic Article
• Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening  Academic Article
• Integrin alpha beta 1, alpha(v)beta, alpha(6)beta effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance  Academic Article
• Interleukin-1 beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases  Academic Article
• Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin alpha v beta 5: implications for angiogenesis in human obesity  Academic Article
• Molecular design and biological-activity of potent and selective protein-kinase inhibitors related to balanol  Academic Article
• MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics  Academic Article
• Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells  Academic Article
• Perspective on computational and structural aspects of kinase discovery from IPK2014  Academic Article
• Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling  Academic Article
• Proteolysis-induced n-terminal ectodomain shedding of the integral membrane glycoprotein cub domain-containing protein 1 (cdcp1) is accompanied by tyrosine phosphorylation of its c-terminal domain and recruitment of src and pkc delta  Academic Article
• Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progession  Academic Article
• Reduced glioma infiltration in Src-deficient mice  Academic Article
• Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif  Academic Article
• Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits  Academic Article
• SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent  Academic Article
• Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a beta-arrestin2/Src/Akt signaling complex in vivo  Academic Article
• Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells  Academic Article
• Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors  Academic Article
• Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity  Academic Article
• Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas  Academic Article
• Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: the role of sphingosine 1-phosphate receptor-4  Academic Article
• Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor  Academic Article
• Src and multiple map kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: Comparison with acute mechanical stretch  Academic Article
• Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction  Academic Article
• Src family kinase and adenosine differentially regulate multiple map kinases in ischemic myocardium: Modulation of map kinases activation by ischernic preconditioning  Academic Article
• TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching  Academic Article
• The cell surface glycoprotein CDCP1 in cancer: insights, opportunities, and challenges  Academic Article