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Nicotinic Agonists

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  • 'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration  Academic Article
  • A novel α2/α4 subtype-selective positive allosteric modulator of nicotinic acetylcholine receptors acting from the C-tail of an α subunit  Academic Article
  • Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats  Academic Article
  • Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mrna in rat hippocampus  Academic Article
  • Adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal  Academic Article
  • Blockade of nicotine self-administration with nicotinic antagonists in rats  Academic Article
  • Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking  Academic Article
  • Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors  Academic Article
  • Contemporary paradigms for cholinergic ligand design guided by biological structure  Academic Article
  • Decreased brain reward function during nicotine withdrawal in c57bl6 mice: Evidence from intracranial self-stimulation (icss) studies  Academic Article
  • Developmental Nicotine Exposure Enhances Inhibitory Synaptic Transmission in Motor Neurons and Interneurons Critical for Normal Breathing  Academic Article
  • Effects of neonatal exposure to nicotine on electrophysiological parameters in adult rats  Academic Article
  • Effects of nicotine and mecamylamine on cognition in rhesus monkeys  Academic Article
  • Evidence for a complex influence of nicotinic acetylcholine receptors on hippocampal serotonin release  Academic Article
  • Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats  Academic Article
  • Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a  Academic Article
  • Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans  Academic Article
  • Increased CRF-like and NPY-like immunoreactivity in adult rats exposed to nicotine during adolescence: Relation to anxiety-like and depressive-like behavior  Academic Article
  • Increased anxiety-like behavior in adult rats exposed to nicotine as adolescents  Academic Article
  • Insular hypocretin transmission regulates nicotine reward  Academic Article
  • Lasting effects of adolescent nicotine exposure on the electroencephalogram, event related potentials, and locomotor activity in the rat  Academic Article
  • Light-induced calcium influx into retinal axons is regulated by presynaptic nicotinic acetylcholine receptor activity in vivo  Academic Article
  • Locomotor response to novelty predicts a rat's propensity to self-administer nicotine  Academic Article
  • Molecular mechanisms underlying behaviors related to nicotine addiction  Academic Article
  • Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats  Academic Article
  • Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion  Academic Article
  • Neonatal nicotine exposure alters hippocampal EEG and event-related potentials (ERPs) in rats  Academic Article
  • Neurobiological mechanisms by which nicotine mediates different types of anxiety  Academic Article
  • Neurobiology of the nicotine withdrawal syndrome  Academic Article
  • Nicotine aversion: neurobiological mechanisms and relevance to tobacco dependence vulnerability  Academic Article
  • Nicotine prevents hivgp120-caused electrophysiological and motor disturbances in rats  Academic Article
  • Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice  Academic Article
  • Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience  Academic Article
  • Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure  Academic Article
  • Patterns of responding differentiate intravenous nicotine self-administration from responding for a visual stimulus in C57BL/6J mice  Academic Article
  • Pharmacological and behavioral profile of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-chinolincarboxamide (EVP-5141), a novel α7 nicotinic acetylcholine receptor agonist/serotonin 5-HT3 receptor antagonist  Academic Article
  • Pleiotropic effects of novel trans-acting loci influencing human sympathochromaffin secretion  Academic Article
  • Prolonged nicotine exposure does not alter gaba(b) receptor-mediated regulation of brain reward function  Academic Article
  • Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons  Academic Article
  • Reduced nnos expression induced by repeated nicotine treatment in mu-opioid receptor knockout mice  Academic Article
  • Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement  Academic Article
  • Selectivity optimization of substituted 1,2,3-triazoles as α7 nicotinic acetylcholine receptor agonists  Academic Article
  • Structure-guided drug design: Conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes  Academic Article
  • Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations  Academic Article
  • Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors  Academic Article
  • Synthesis of selective agonists for the alpha 7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates  Academic Article
  • Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors  Academic Article
  • Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists  Academic Article
  • The cholinergic system is involved in regulation of the development of the hematopoietic system  Academic Article
  • The effects of corticotropin-releasing factor on the cortical EEG are reduced following adolescent nicotine exposure  Academic Article
  • The novel α7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran- 2-carboxamide improves working and recognition memory in rodents  Academic Article
  • The p300 brain potential is reduced in smokers  Academic Article
  • The role of fatty acid amide hydrolase inhibition in nicotine reward and dependence  Academic Article
  • Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration  Academic Article

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