subject area of

• 2,6-diamino-5,8-diaza-7,9-dicarba-purine  Academic Article
• "Chiral amnesia" as a driving force for solid-phase homochirality  Academic Article
• ... The tyranny of the lattice  Academic Article
• 1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): a potent, orally bioavailable, and short-duration growth hormone secretagogue  Academic Article
• 1.35 and 2.07 a resolution structures of the red abalone sperm lysin monomer and dimer reveal features involved in receptor binding  Academic Article
• 1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore  Academic Article
• 2,5-diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3)  Academic Article
• 2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations  Academic Article
• 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor  Academic Article
• 2-Amino- 1,2,4 triazolo 1,5-a pyridines as JAK2 inhibitors  Academic Article
• 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution  Academic Article
• 2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy  Academic Article
• 3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle  Academic Article
• 3,5-disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors  Academic Article
• 3D domain swapping modulates the stability of members of an icosahedral virus group  Academic Article
• 4-Aminoindazolyl-dihydrofuro 3,4-d pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase  Academic Article
• 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency  Academic Article
• A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton  Academic Article
• A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from trypanosoma brucei  Academic Article
• A chemical genomic analysis of decoquinate, a plasmodium falciparum cytochrome b inhibitor  Academic Article
• A comparative analysis of the immunological evolution of antibody 28B4  Academic Article
• A comparison of the atomic model of F-actin with cryo-electron micrographs of actin and decorated actin  Academic Article
• A computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells  Academic Article
• A concise asymmetric total synthesis of aspidophytine  Academic Article
• A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies  Academic Article
• A conservative isoleucine to leucine mutation causes major rearrangements and cold sensitivity in KlenTaq1 DNA polymerase  Academic Article
• A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis  Academic Article
• A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from bacteroides thetaiotaomicron at 2.2 A resolution  Academic Article
• A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant  Academic Article
• A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome  Academic Article
• A density functional evaluation of an Fe(III)-Fe(IV) model diiron cluster: comparisons with ribonucleotide reductase intermediate X  Academic Article
• A discovery strategy for selective inhibitors of c-Src in complex with the focal adhesion kinase SH3/SH2-binding region  Academic Article
• A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis  Academic Article
• A dynamic structural model of expanded RNA CAG repeats: A refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations  Academic Article
• A fence-like coat for the nuclear pore membrane  Academic Article
• A fluorinated ligand enables room-temperature and regioselective Pd-catalyzed fluorination of aryl triflates and bromides  Academic Article
• A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking  Academic Article
• A functional hot spot for antigen recognition in a superagonist TCR/MHC complex  Academic Article
• A genetically encoded diazirine photocrosslinker in Escherichia coli  Academic Article
• A glutamate switch controls voltage-sensitive phosphatase function  Academic Article
• A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase  Academic Article
• A helix replacement mechanism directs metavinculin functions  Academic Article
• A heterocyclic peptide nanotube  Academic Article
• A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV  Academic Article
• A highly conserved neutralizing epitope on group 2 influenza a viruses  Academic Article
• A highly diastereo- and enantioselective synthesis of multisubstituted cyclopentanes with four chiral carbons by the organocatalytic domino Michael-Henry reaction  Academic Article
• A highly effective nonpolar isostere of deoxyguanosine: synthesis, structure, stacking, and base pairing  Academic Article
• A highly stereoselective organocatalytic tandem aminoxylation/aza-Michael reaction for the synthesis of tetrahydro-1,2-oxazines  Academic Article
• A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol  Academic Article
• A human-infecting H10N8 influenza virus retains a strong preference for avian-type receptors  Academic Article
• A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein  Academic Article
• A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes - crystal structure of human leukocyte antigen (hla)-a1-mage-a1 in complex with fab-hyb3  Academic Article
• A maltose-binding protein fusion construct yields a robust crystallography platform for MCL1  Academic Article
• A molecular dynamics simulation study of segment B1 of protein G  Academic Article
• A molecular switch regulating transcriptional repression and activation of PPARγ  Academic Article
• A mutational study of a Diels-Alderase catalytic antibody  Academic Article
• A new functional domain of guanine nucleotide dissociation inhibitor (alpha-gdi) involved in rab recycling  Academic Article
• A new method for the stereoselective synthesis of α- and β-glycosylamines using the burgess reagent  Academic Article
• A new regulatory switch in a JAK protein kinase  Academic Article
• A nonself sugar mimic of the hiv glycan shield shows enhanced antigenicity  Academic Article
• A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies  Academic Article
• A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A  Academic Article
• A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase  Academic Article
• A novel cryoprotection scheme for enhancing the diffraction of crystals of recombinant cytochrome ba3 oxidase from thermus thermophilus  Academic Article
• A novel in silico approach to drug discovery via computational intelligence  Academic Article
• A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase  Academic Article
• A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA  Academic Article
• A peptide inhibitor of hiv-1 neutralizing antibody 2g12 is not a structural mimic of the natural carbohydrate epitope on gp120  Academic Article
• A peptide that antagonizes tcr-mediated reactions with both syngeneic and allogeneic agonists: Functional and structural aspects  Academic Article
• A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield  Academic Article
• A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke  Academic Article
• A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin  Academic Article
• A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state  Academic Article
• A remarkable ring contraction en route to the chartelline alkaloids  Academic Article
• A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: Crystal structure of spo0f from bacillus subtilis  Academic Article
• A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases  Academic Article
• A shared structural solution for neutralizing ebolaviruses  Academic Article
• A simple strategy towards membrane protein purification and crystallization  Academic Article
• A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure  Academic Article
• A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region  Academic Article
• A small molecule RAS-mimetic disrupts RAS association with effector proteins to block signaling  Academic Article
• A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor  Academic Article
• A stereoselective hydroamination transform to access polysubstituted indolizidines  Academic Article
• A structural basis for the regulatory inactivation of DnaA  Academic Article
• A structural framework for deciphering the link between I-A(g7) and autoimmune diabetes  Academic Article
• A structural model for the prostate disease marker, human prostate-specific antigen  Academic Article
• A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states  Academic Article
• A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union  Academic Article
• A substrate mimic allows high-throughput assay of the FabA protein and consequently the identification of a novel inhibitor of pseudomonas aeruginosa FabA  Academic Article
• A surface on the androgen receptor that allosterically regulates coactivator binding  Academic Article
• A synthesis of the carbon skeleton of maoecrystal v  Academic Article
• A synthetic receptor for choline and carnitine  Academic Article
• A t14c variant of azotobacter vinelandii ferredoxin i undergoes facile 3fe-4s degrees to 4fe-4s (2+) conversion in vitro but not in vivo  Academic Article
• A total synthesis trilogy: Calicheamicin gamma 1i, taxol (r), and brevetoxin a  Academic Article
• A weak attractive interaction between organic fluorine and an amide group  Academic Article
• AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin  Academic Article
• ALG-2 divalent-ion affinity: Calorimetric analysis of the des23 versions reveals high-affinity site for Mg2+  Academic Article
• ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization  Academic Article
• ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase  Academic Article
• ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling  Academic Article
• Abalone lysin: The dissolving and evolving sperm protein  Academic Article
• Acceleration of nucleophilic ch activation by strongly basic solvents  Academic Article
• Acidophilic adaptations in the structure of Acetobacter aceti N-5-carboxyaminoimidazole ribonucleotide mutase (PurE)  Academic Article
• Actin crystal dynamics: structural implications for F-actin nucleation, polymerization, and branching mediated by the anti-parallel dimer  Academic Article
• Active and alkylated human agt structures: A novel zinc site, inhibitor and extrahelical base binding  Academic Article
• Active and inhibited human catalase structures: Ligand and nadph binding and catalytic mechanism  Academic Article
• Active site binding modes of curcumin in HIV-1 protease and integrase  Academic Article
• Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations  Academic Article
• Active-site and oligosaccharide recognition residues of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f  Academic Article
• Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2  Academic Article
• Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans  Academic Article
• Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes  Academic Article
• Agonist-bound structure of the human P2Y(12) receptor  Academic Article
• Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence  Academic Article
• Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition  Academic Article
• Alexander Rich (1924-2015)  Academic Article
• Alkyltransferase-like protein (atl1) distinguishes alkylated guanines for DNA repair using cation-pi interactions  Academic Article
• Allosteric communication in the dynein motor domain  Academic Article
• Allosteric inhibition of human ribonucleotide reductase by dATP entails the stabilization of a hexamer  Academic Article
• Allosteric inhibition of hypoxia inducible factor-2 with small molecules  Academic Article
• Allosteric inhibition via R-state destabilization in ATP sulfurylase from Penicillium chrysogenum  Academic Article
• Altering substrate specificity at the heme edge of cytochrome c peroxidase  Academic Article
• Alternative conformations of a nucleic acid four-way junction  Academic Article
• Amino acid substitution at the dimeric interface of human manganese superoxide dismutase  Academic Article
• An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain  Academic Article
• An EB1-binding motif acts as a microtubule tip localization signal  Academic Article
• An S(N)Ar approach to sterically hindered ortho-alkoxybenzaldehydes for the synthesis of olefin metathesis catalysts  Academic Article
• An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide  Academic Article
• An alpha beta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex  Academic Article
• An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode  Academic Article
• An antagonist peptide epo receptor complex suggests that receptor dimerization is not sufficient for activation  Academic Article
• An antibody CDR3-erythropoietin fusion protein  Academic Article
• An antibody exo Diels-Alderase inhibitor complex at 1.95 Å resolution  Academic Article
• An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket  Academic Article
• An automated procedure for detecting protein folds from sub-nanometer resolution electron density  Academic Article
• An efficient platform for screening expression and crystallization of glycoproteins produced in human cells  Academic Article
• An electrostatic mechanism for Ca2+ -mediated regulation of gap junction channels  Academic Article
• An enantioselective synthesis of insecticidal 4-alkynyloxazolines  Academic Article
• An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured  Academic Article
• An escherichia coli-based cell-free system for large-scale production of functional mammalian membrane proteins suitable for x-ray crystallography  Academic Article
• An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity  Academic Article
• An expedient synthesis of a functionalized core structure of bielschowskysin  Academic Article
• An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging  Academic Article
• An insight into the interaction mode between CheB and chemoreceptor from two crystal structures of CheB methylesterase catalytic domain  Academic Article
• An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity  Academic Article
• An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance  Academic Article
• An online resource for GPCR structure determination and analysis  Academic Article
• An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution  Academic Article
• An unexpected outcome of surface engineering an integral membrane protein: Improved crystallization of cytochrome ba(3) from thermus thermophilus  Academic Article
• An unexpected twist in viral capsid maturation  Academic Article
• An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer  Academic Article
• An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene  Academic Article
• An α/β-peptide helix bundle with a pure β3-amino acid core and a distinctive quaternary structure  Academic Article
• Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise  Academic Article
• Analysis of hapten binding and catalytic determinants in a family of catalytic antibodies  Academic Article
• Analysis of the class i aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99 Å resolution  Academic Article
• Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase  Academic Article
• Ancient tRNA synthetase meets modern structural biology  Academic Article
• Anion-exchange-triggered 1,3-shift of an NH proton to iridium in protic n-heterocyclic carbenes: Hydrogen-bonding and ion-pairing effects  Academic Article
• Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres  Academic Article
• Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike  Academic Article
• Antibody 2g12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the hiv-1 glycan shield if domain exchanged  Academic Article
• Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike  Academic Article
• Antibody binding defines a structure for an epitope that participates in the prpc -> prpsc conformational change  Academic Article
• Antibody catalysis of the oxidation of water  Academic Article
• Antibody domain exchange is an immunological solution to carbohydrate cluster recognition  Academic Article
• Antibody modeling assessment II. Structures and models  Academic Article
• Antibody recognition of a highly conserved influenza virus epitope  Academic Article
• Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site  Academic Article
• Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation  Academic Article
• Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation  Academic Article
• Antifungal azoles: structural insights into undesired tight binding to cholesterol-metabolizing CYP46A1  Academic Article
• Antigen recognition by variable lymphocyte receptors  Academic Article
• Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic  Academic Article
• Apo raver1 structure reveals distinct RRM domain orientations  Academic Article
• Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network  Academic Article
• Architecture of the Soluble Receptor Aer2 Indicates an In-Line Mechanism for PAS and HAMP Domain Signaling  Academic Article
• Architecture of the complex formed by large and small terminase subunits from bacteriophage P22  Academic Article
• Architecture of the flagellar rotor  Academic Article
• Architecture of the mediator head module  Academic Article
• Architectures of lipid transport systems for the bacterial outer membrane  Academic Article
• Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor  Academic Article
• Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein  Academic Article
• Arylation of rhodium(II) azavinyl carbenes with boronic acids  Academic Article
• Asia growth in membrane protein structure  Academic Article
• Assembly of acanthamoeba myosin-ii minifilaments. Model of anti-parallel dimers based on em and x-ray diffraction of 2d and 3d crystals  Academic Article
• Assembly states of FliM and FliG within the flagellar switch complex  Academic Article
• Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure  Academic Article
• Asymmetric electrophilic fluorocyclization with carbon nucleophiles  Academic Article
• Asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI)  Academic Article
• Asymmetric synthesis of pochonin E and F, revision of their proposed structure, and their conversion to potent Hsp90 inhibitors  Academic Article
• Asymmetric synthesis of quaternary alpha- and beta-amino acids and beta-lactams via proline-catalyzed mannich reactions with branched aldehyde donors  Academic Article
• Atl1 regulates choice between global genome and transcription-coupled repair of o-6-alkylguanines  Academic Article
• Atomic and residue hydrophilicity in the context of folded protein structures  Academic Article
• Atomic structure of the 75 MDa extremophile Sulfolobus turreted icosahedral virus determined by CryoEM and X-ray crystallography  Academic Article
• Atomic-level modelling of the HIV capsid  Academic Article
• AutoDock4(Zn): an improved AutoDock force field for small-molecule docking to zinc metalloproteins  Academic Article
• AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery  Academic Article
• Automated docking of ligands to an artificial active site: augmenting crystallographic analysis with computer modeling  Academic Article
• Automated identification of functional dynamic contact networks from X-ray crystallography  Academic Article
• Automated sample mounting and alignment system for biological crystallography at a synchrotron source  Academic Article
• Automated three-dimensional reconstruction of keyhole limpet hemocyanin type 1  Academic Article
• Automation of x-ray crystallography  Academic Article
• Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential  Academic Article
• Azotobacter-vinelandii ferredoxin-i - alteration of individual surface-charges and the 4fe-4s (2+/+) cluster reduction potential  Academic Article
• Azotobacter-vinelandii ferredoxin-i - aspartate-15 facilitates proton-transfer to the reduced 3fe-4s cluster  Academic Article
• Azurin as a protein scaffold for a low-coordinate nonheme iron site with a small-molecule binding pocket  Academic Article
• Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins  Academic Article
• Bacterial pleckstrin homology domains: A prokaryotic origin for the PH domain  Academic Article
• Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery  Academic Article
• Base excision repair enzyme family portrait: Integrating the structure and chemistry of an entire DNA repair pathway  Academic Article
• Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA  Academic Article
• Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain  Academic Article
• Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis, evaluation, and mechanism of action  Academic Article
• Biggest virus molecular structure yet!  Academic Article
• Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures  Academic Article
• Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51  Academic Article
• Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors  Academic Article
• Biochemical characterization and crystal structure of a dim1 family associated protein: Dim2  Academic Article
• Biochemical characterization and structural analysis of a highly proficient cocaine esterase  Academic Article
• Biogenesis of the secretory granule: Chromogranin a coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation  Academic Article
• Biomimetic synthesis of antimalarial naphthoquinones  Academic Article
• Biophysical characterization of a β-peptide bundle: Comparison to natural proteins  Academic Article
• Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation  Academic Article
• Bistable cucurbituril rotaxanes without stoppers  Academic Article
• Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from naja atra venom that targets the BKCa channel  Academic Article
• Blu-ice and the distributed control system: Software for data acquisition and instrument control at macromolecular crystallography beamlines  Academic Article
• Blue-fluorescent antibodies  Academic Article
• Breaking cryo-EM resolution barriers to facilitate drug discovery  Academic Article
• Breaking the low barrier hydrogen bond in a serine protease  Academic Article
• Broadly neutralizing anti-hiv antibody 4e10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41  Academic Article
• Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans  Academic Article
• Broken symmetry DFT calculations/analysis for oxidized and reduced dinuclear center in cytochrome c oxidase: relating structures, protonation states, energies, and Mössbauer properties in ba3 thermus thermophilus  Academic Article
• Brush border myosin-i structure and adp-dependent conformational changes revealed by cryoelectron microscopy and image analysis  Academic Article
• C-2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and hiv/fiv proteases  Academic Article
• Calculations of electrostatic interactions and pK(a)s in the active site of Escherichia coli thioredoxin  Academic Article
• Capsid conformational sampling in HK97 maturation visualized by X-ray crystallography and cryo-EM  Academic Article
• Carbon-deuterium bonds as probes of dihydrofolate reductase  Academic Article
• Carbonic anhydrase inhibitors. Interaction of 2-n,n-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: Kinetic and x-ray crystallographic studies  Academic Article
• Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: Crystal structures of abzyme 21D8  Academic Article
• Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: Insertion of valine Cγ into the substrate access channel  Academic Article
• Catalytic antibodies - structure and function  Academic Article
• Catalytic asymmetric formal [4 + 1] annulation leading to optically active cis-isoxazoline N-oxides  Academic Article
• Cavitand-porphyrins  Academic Article
• Cbp/p300 taz1 domain forms a structured scaffold for ligand binding  Academic Article
• Changes in active site histidine hydrogen bonding trigger cryptochrome activation  Academic Article
• Characterization and inactivation of an agmatine deiminase from helicobacter pylori  Academic Article
• Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode  Academic Article
• Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site  Academic Article
• Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry  Academic Article
• Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro  Academic Article
• Characterization of the electrophile binding site and substrate binding mode of the 26-kda glutathione s-transferase from schistosoma japonicum  Academic Article
• Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain  Academic Article
• Characterization of y122f r2 of escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and x-ray crystallography  Academic Article
• Characterizing flexible and intrinsically unstructured biological macromolecules by sas using the porod-debye law  Academic Article
• Charting a path to success in virtual screening  Academic Article
• Chasing molecules that were never there: Misassigned natural products and the role of chemical synthesis in modern structure elucidation  Academic Article
• Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis  Academic Article
• Chemical modification of viruses and virus-like particles  Academic Article
• Chemical tools for studying the impact of cis/trans prolyl isomerization on signaling: a case study on RNA polymerase II phosphatase activity and specificity  Academic Article
• Chemical tools to decipher regulation of phosphatases by proline isomerization on eukaryotic RNA polymerase II  Academic Article
• Chemoenzymatic synthesis of GDP-L-fucose and the Lewis X glycan derivatives  Academic Article
• Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environment  Academic Article
• Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma  Academic Article
• Chemotype-selective modes of action of κ-opioid receptor agonists  Academic Article
• Cheshift-2 resolves a local inconsistency between two x-ray crystal structures  Academic Article
• Chimeragenesis of distantly-related proteins by noncontiguous recombination  Academic Article
• Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes  Academic Article
• Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype A protease  Academic Article
• Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction  Academic Article
• Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7)  Academic Article
• Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase  Academic Article
• Closely related antibody receptors exploit fundamentally different strategies for steroid recognition  Academic Article
• Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus  Academic Article
• Co-folding of a FliF-FliG split domain forms the basis of the MS:C ring interface within the bacterial flagellar motor  Academic Article
• Coaxing a pyridine nucleus to give up its aromaticity: synthesis and pharmacological characterization of novel conformationally restricted analogues of nicotine and anabasine  Academic Article
• Cofactor-containing antibodies: Crystal structure of the original yellow antibody  Academic Article
• Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution  Academic Article
• Combinatorial crystallization of an rna-protein complex  Academic Article
• Combined microspectrophotometric and crystallographic examination of chemically reduced and x-ray radiation-reduced forms of cytochrome ba(3) oxidase from thermus thermophilus: Structure of the reduced form of the enzymes  Academic Article
• Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the gamma delta t-cell ligand t10  Academic Article
• Combining h/d exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase  Academic Article
• Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008  Academic Article
• Comparative structural analysis of a novel glutathione S-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 Å resolution  Academic Article
• Comparative studies of T=3 and T=4 icosahedral RNA insect viruses  Academic Article
• Comparison of NMR and crystal structures for the proteins TM1112 and TM1367  Academic Article
• Comparison of NMR and crystal structures highlights conformational isomerism in protein active sites  Academic Article
• Complementary approaches to structure determination of icosahedral viruses  Academic Article
• Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer  Academic Article
• Complete structural model of Escherichia coli RNA polymerase from a hybrid approach  Academic Article
• Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold  Academic Article
• Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic hiv vaccine epitope  Academic Article
• Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope  Academic Article
• Computational fragment-based binding site identification by ligand competitive saturation  Academic Article
• Computational protein design using flexible backbone remodeling and resurfacing: case studies in structure-based antigen design  Academic Article
• Conformational adaptation of human cytochrome p450 2b6 and rabbit cytochrome p450 2b4 revealed upon binding multiple amlodipine molecules  Academic Article
• Conformational analysis of galanin using end to end distance distribution observed by Förster resonance energy transfer  Academic Article
• Conformational change in the nadp(h) binding domain of transhydrogenase defines four states  Academic Article
• Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: A possible inhibition mechanism for the key enzyme in polymyxin resistance  Academic Article
• Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: implications for enzyme mechanism  Academic Article
• Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas Campestris pv. Campestris  Academic Article
• Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency  Academic Article
• Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding  Academic Article
• Conformational diversity in nad(h) and interacting transhydrogenase nicotinamide nucleotide binding domains  Academic Article
• Conformational flexibility in crystal structures of human 11 β-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation  Academic Article
• Conformational flexibility in the flap domains of ligand-free HIV protease  Academic Article
• Conformational flexibility of b-DNA at 0.74 Å resolution: D(ccagtactgg)(2)  Academic Article
• Conformational flexibility underlies ubiquitin ligation mediated by the WWP1HECT domain E3 ligase  Academic Article
• Conformational heterogeneity and the affinity of substrate molecular recognition by cytochrome P450cam  Academic Article
• Conformational isomerism can limit antibody catalysis  Academic Article
• Conformational polymorphism of cyclosporine-a  Academic Article
• Conformational states of cytochrome p450cam revealed by trapping of synthetic molecular wires  Academic Article
• Conformational switching in the fungal light sensor vivid  Academic Article
• Conformational transitions that enable histidine kinase autophosphorylation and receptor array integration  Academic Article
• Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: Receptor-selective somatostatin analogues  Academic Article
• Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors  Academic Article
• Conserved binding mode of human beta(2) adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography  Academic Article
• Conserved glycine 232 in the ligand channel of ba(3) cytochrome oxidase from Thermus thermophilus  Academic Article
• Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes  Academic Article
• Conserved xpb core structure and motifs for DNA unwinding: Implications for pathway selection of transcription or excision repair  Academic Article
• Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c  Academic Article
• Construction of highly functionalized medium-sized rings: Synthesis of hyperforin and perforatumone model systems  Academic Article
• Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system  Academic Article
• Contrasting IgG structures reveal extreme asymmetry and flexibility  Academic Article
• Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis  Academic Article
• Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding  Academic Article
• Control of four stereocenters in an organocatalytic domino double Michael reaction: Efficient synthesis of multisubstituted cyclopentanes  Academic Article
• Controlling conformational flexibility of an O(2)-binding H-NOX domain  Academic Article
• Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis  Academic Article
• Copper-based pulsed dipolar ESR spectroscopy as a probe of protein conformation linked to disease states  Academic Article
• Copper-free cycloaddition of azide and alkyne in crystalline state facilitated by arene-perfluoroarene interactions  Academic Article
• Core structure of the yeast spt4-spt5 complex: A conserved module for regulation of transcription elongation  Academic Article
• Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies  Academic Article
• Cortistatin a is a high-affinity ligand of protein kinases rock, cdk8, and cdk11  Academic Article
• Coupled redox potentials in manganese and iron superoxide dismutases from reaction kinetics and density functional/electrostatics calculations  Academic Article
• Coupling of hydrogen bonding to chromophore conformation and function in photoactive yellow protein  Academic Article
• Cross-neutralization of influenza a viruses mediated by a single antibody loop  Academic Article
• Crosslinking of and coupling to viral capsid proteins by tyrosine oxidation  Academic Article
• Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function  Academic Article
• Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer  Academic Article
• Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome  Academic Article
• Crystal and solution structures of an HslUV protease-chaperone complex  Academic Article
• Crystal structure and activity studies of the C11 cysteine peptidase from parabacteroides merdae in the human gut microbiome  Academic Article
• Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis  Academic Article
• Crystal structure and modeling of the tetrahedral intermediate state of methylmalonate-semialdehyde dehydrogenase (MMSDH) from Oceanimonas doudoroffii  Academic Article
• Crystal structure and novel recognition motif of rho adp-ribosylating c3 exoenzyme from clostridium botulinum: Structural insights for recognition specificity and catalysis  Academic Article
• Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase  Academic Article
• Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 Å resolution reveals a new fold with a novel active site  Academic Article
• Crystal structure of 3-hydroxyanthranilic acid 3,4-dioxygenase from saccharomyces cerevisiae: A special subgroup of the type III extradiol dioxygenases  Academic Article
• Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 Å resolution  Academic Article
• Crystal structure of ATP sulfurylase from the bacterial symbiont of the hydrothermal vent tubeworm Riftia pachyptila  Academic Article
• Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism  Academic Article
• Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: Implications for Lsm ring organisation and recruitment  Academic Article
• Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif  Academic Article
• Crystal structure of Marburg virus VP24  Academic Article
• Crystal structure of Marburg virus VP40 reveals a broad, basic patch for matrix assembly and a requirement of the N-terminal domain for immunosuppression  Academic Article
• Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis  Academic Article
• Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 Å resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy3-keto-5-methylthiopentenyl-1-phosphate  Academic Article
• Crystal structure of NMA 1982 from Neisseria meningiddis at 1.5 Å resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases  Academic Article
• Crystal structure of NMC-4 fab anti-von Willebrand factor A1 domain  Academic Article
• Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution  Academic Article
• Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1  Academic Article
• Crystal structure of Pasteurella haemolytica ferric ion-binding protein a reveals a novel class of bacterial iron-binding proteins  Academic Article
• Crystal structure of S-adenosylmethionine : tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold  Academic Article
• Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1  Academic Article
• Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue  Academic Article
• Crystal structure of TM1030 from THermotoga maritima at 2.3 Å resolution reveals molecular details of its transcription repressor function  Academic Article
• Crystal structure of TM1367 from Thermotoga maritima at 1.90 Å resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold  Academic Article
• Crystal structure of Trbp111: a structure-specific tRNA-binding protein  Academic Article
• Crystal structure of UbiX, an aromatic acid decarboxylase from the psychrophilic bacterium Colwellia psychrerythraea that undergoes FMN-induced conformational changes  Academic Article
• Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3 '-> 2 ') nucleosides: A four-carbon sugar is easily accommodated into the backbone of DNA  Academic Article
• Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution  Academic Article
• Crystal structure of a bacterial cocaine esterase  Academic Article
• Crystal structure of a bifunctional deaminase and reductase from Bacillus subtilis involved in riboflavin biosynthesis  Academic Article
• Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis  Academic Article
• Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin  Academic Article
• Crystal structure of a cocaine-binding antibody  Academic Article
• Crystal structure of a conserved hypothetical protein (gi : 13879369) from Mouse at 1.90 A resolution reveals a new fold  Academic Article
• Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution  Academic Article
• Crystal structure of a divalent metal ion transporter CorA at 2.9 Å resolution  Academic Article
• Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold  Academic Article
• Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262  Academic Article
• Crystal structure of a gamma delta t cell receptor ligand t22: A truncated mhc-like fold  Academic Article
• Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 Å resolution reveals a new fold  Academic Article
• Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 Å resolution  Academic Article
• Crystal structure of a human aminoacyl-tRNA synthetase cytokine  Academic Article
• Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity  Academic Article
• Crystal structure of a lipid G protein-coupled receptor  Academic Article
• Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution  Academic Article
• Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch  Academic Article
• Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design  Academic Article
• Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 Å resolution  Academic Article
• Crystal structure of a novel archaeal AAA plus ATPase SSO 1545 from Sulfolobus solfataricus  Academic Article
• Crystal structure of a phosphatase-resistant mutant of sporulation response regulator spo0f from bacillus subtilis  Academic Article
• Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77 Å resolution  Academic Article
• Crystal structure of a putative NADPH-dependent oxidoreductase (GI : 18204011) from mouse at 2.10 Å resolution  Academic Article
• Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2.5 Å resolution  Academic Article
• Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1.7 Å resolution  Academic Article
• Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 Å resolution reveals a new fold  Academic Article
• Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution  Academic Article
• Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family  Academic Article
• Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 Å resolution  Academic Article
• Crystal structure of a shark single-domain antibody v region in complex with lysozyme  Academic Article
• Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 a resolution  Academic Article
• Crystal structure of a soluble cleaved HIV-1 envelope trimer  Academic Article
• Crystal structure of a transcription regulator (TM1602) from Thermotoga maritima at 2.3 Å resolution  Academic Article
• Crystal structure of a two-subunit TrkA octameric gating ring assembly  Academic Article
• Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 Å resolution  Academic Article
• Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 Å resolution  Academic Article
• Crystal structure of adenosine 5 '-phosphosulfate kinase from Penicillium chrysogenum  Academic Article
• Crystal structure of an ADP-ribosylated protein with a cytidine deaminase-like fold, but unknown function (TM 1506), from Thermatoga maritima at 2.70 Å resolution  Academic Article
• Crystal structure of an Apo mRNA decapping enzyme (DcpS) from mouse at 1.83 Å resolution  Academic Article
• Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3  Academic Article
• Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 Å resolution  Academic Article
• Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 Å resolution reveals a fold similar to the Ran-binding protein Mog1p  Academic Article
• Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 Å resolution  Academic Article
• Crystal structure of an alanine-glyoxylate aminotransferase from anabaena sp at 1.70 A resolution reveals a noncovalently linked PLP cofactor  Academic Article
• Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 Å resolution  Academic Article
• Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 Å resolution  Academic Article
• Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 Å resolution  Academic Article
• Crystal structure of an indigoidine synthase A (IndA)-like protein (TM64) from Thermotoga maritima at 1.90 A resolution reveals a new fold  Academic Article
• Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design  Academic Article
• Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 Å resolution  Academic Article
• Crystal structure of an isolated V(alpha) domain of the 2C T-cell receptor  Academic Article
• Crystal structure of an mhc class i presented glycopeptide that generates carbohydrate-specific ctl  Academic Article
• Crystal structure of an orphan protein (TM0875) from thermotoga maritima at 2.00 Å resolution reveals a new fold  Academic Article
• Crystal structure of antagonist bound human lysophosphatidic acid receptor 1  Academic Article
• Crystal structure of aplysia adp ribosyl cyclase, a homologue of the bifunctional ectozyme cd38  Academic Article
• Crystal structure of archaeal ribonuclease P protein aRpp29 from Archaeoglobus fulgidus  Academic Article
• Crystal structure of atp sulfurylase from penicillium chrysogenum: Insights into the allosteric regulation of sulfate assimilation  Academic Article
• Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening  Academic Article
• Crystal structure of botulinum neuro-toxin type a and implications for toxicity  Academic Article
• Crystal structure of botulinum neurotoxin type a in complex with the cell surface co-receptor gt1b - insight into the toxin-neuron interaction  Academic Article
• Crystal structure of botulinum neurotoxin type g light chain: Serotype divergence in substrate recognition  Academic Article
• Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor urb597: Discovery of a deacylating water molecule and insight into enzyme inactivation  Academic Article
• Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5  Academic Article
• Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 Å resolution  Academic Article
• Crystal structure of histidine phosphotransfer protein ShpA, an essential regulator of stalk biogenesis in Caulobacter crescentus  Academic Article
• Crystal structure of homoserine o-succinyltransferase from bacillus cereus at 2.4 Å resolution  Academic Article
• Crystal structure of hsiuv complexed with a vinyl sulfone inhibitor: Corroboration of a proposed mechanism of allosteric activation of hsiv by hsiu  Academic Article
• Crystal structure of human adenovirus at 3.5 Å resolution  Academic Article
• Crystal structure of human antibody 2909 reveals conserved features of quaternary structure-specific antibodies that potently neutralize HIV-1  Academic Article
• Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition  Academic Article
• Crystal structure of human cytochrome p450 2d6 with prinomastat bound  Academic Article
• Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping  Academic Article
• Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue  Academic Article
• Crystal structure of human ornithine transcarbamylase complexed with carbamoyl phosphate and L-norvaline at 1.9 A resolution  Academic Article
• Crystal structure of human seryl-tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes  Academic Article
• Crystal structure of human toll-like receptor 3 (tlr3) ectodomain  Academic Article
• Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A  Academic Article
• Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites  Academic Article
• Crystal structure of human vinculin  Academic Article
• Crystal structure of misoprostol bound to the labor inducer prostaglandin E-2 receptor  Academic Article
• Crystal structure of mouse cd1: An mhc-like fold with a large hydrophobic binding groove  Academic Article
• Crystal structure of mouse cd1d bound to the self ligand phosphatidylcholine: A molecular basis for nkt cell activation  Academic Article
• Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (trem-1) at 1.76 Å  Academic Article
• Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs  Academic Article
• Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from thermotoga maritima at 1.90 Å resolution  Academic Article
• Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 Å-resolution  Academic Article
• Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser  Academic Article
• Crystal structure of soluble md-1 and its interaction with lipid iva  Academic Article
• Crystal structure of staphylococcus aureus transglycosylase in complex with a lipid ii analog and elucidation of peptidoglycan synthesis mechanism  Academic Article
• Crystal structure of tetrameric form of human lysyl-tRNA synthetase: implications for multisynthetase complex formation  Academic Article
• Crystal structure of the 100 kda arsenite oxidase from alcaligenes faecalis in two crystal forms at 1.64 Å and 2.03 Å  Academic Article
• Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain  Academic Article
• Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 Å resolution  Academic Article
• Crystal structure of the C-terminal domain of mouse TLR9  Academic Article
• Crystal structure of the DNA-recognition component of the bacterial virus sf6 genome-packaging machine  Academic Article
• Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution  Academic Article
• Crystal structure of the Fic (Filamentation induced by cAMP) family protein SO4266 (gi|24375750) from Shewanella oneidensis MR-1 at 1.6 A resolution  Academic Article
• Crystal structure of the Formin mDia1 in autoinhibited conformation  Academic Article
• Crystal structure of the Frizzled 4 receptor in a ligand-free state  Academic Article
• Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose  Academic Article
• Crystal structure of the N-terminal domains of the surface cell antigen 4 of Rickettsia  Academic Article
• Crystal structure of the Nipah virus phosphoprotein tetramerization domain  Academic Article
• Crystal structure of the TCR co-receptor CD8 alpha alpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution  Academic Article
• Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran  Academic Article
• Crystal structure of the anti-viral apobec3g catalytic domain and functional implications  Academic Article
• Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding  Academic Article
• Crystal structure of the broadly cross-reactive hiv-1-neutralizing fab x5 and fine mapping of its epitope  Academic Article
• Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine  Academic Article
• Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin a  Academic Article
• Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a k(+) channel inhibitor-like fold  Academic Article
• Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair  Academic Article
• Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 Å resolution reveals a new fold  Academic Article
• Crystal structure of the gtpase domain of rat dynamin 1  Academic Article
• Crystal structure of the human 4-1BB/4-1BBL complex  Academic Article
• Crystal structure of the human n-myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor  Academic Article
• Crystal structure of the lactose operon repressor and its complexes with DNA and inducer  Academic Article
• Crystal structure of the membrane-bound bifunctional transglycosylase pbp1b from escherichia coli  Academic Article
• Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A  Academic Article
• Crystal structure of the oligomeric form of Lassa virus matrix protein Z  Academic Article
• Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of camp-dependent protein kinase  Academic Article
• Crystal structure of the spindle assembly checkpoint protein Bub3  Academic Article
• Crystal structure of the transcriptional repressor pagr of bacillus anthracis  Academic Article
• Crystal structure of the von Willebrand factor A1 domain in complex with the function blocking NMC-4 Fab  Academic Article
• Crystal structure of the von Willebrand factor modulator botrocetin  Academic Article
• Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892  Academic Article
• Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 Å resolution  Academic Article
• Crystal structure of tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex  Academic Article
• Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases  Academic Article
• Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 Å resolution: Self-hydroxylation of phe300 and the pterin-binding site  Academic Article
• Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2.85 Å resolution  Academic Article
• Crystal structure of viral macrophage inflammatory protein i encoded by kaposi's sarcoma-associated herpesvirus at 1.7 a  Academic Article
• Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 Å resolution reveals a new fold  Academic Article
• Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34  Academic Article
• Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis  Academic Article
• Crystal structures of MW1337R and lin2004: Representatives of a novel protein family that adopt a four-helical bundle fold  Academic Article
• Crystal structures of a quorum-quenching antibody  Academic Article
• Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP  Academic Article
• Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine  Academic Article
• Crystal structures of apolipoprotein(a) kringle iv37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: Existence of novel and expected binding modes  Academic Article
• Crystal structures of cytochrome p450 2b4 in complex with the inhibitor 1-biphenyl-4-methyl-1h-imidazole: Ligand-induced structural response through alpha-helical repositioning  Academic Article
• Crystal structures of ferredoxin variants exhibiting large changes in fe-s reduction potential  Academic Article
• Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases  Academic Article
• Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR  Academic Article
• Crystal structures of human HSP90 alpha-complexed with dihydroxyphenylpyrazoles  Academic Article
• Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates  Academic Article
• Crystal structures of human immunodeficiency virus type 1 (hiv-1) neutralizing antibody 2219 in complex with three different v3 peptides reveal a new binding mode for hiv-1 cross-reactivity  Academic Article
• Crystal structures of human topoisomerase i in covalent and noncovalent complexes with DNA  Academic Article
• Crystal structures of leukotriene a(4) hydrolase in complex with captopril and two competitive tight-binding inhibitors  Academic Article
• Crystal structures of mouse CD1d-iGb3 complex and its cognate v alpha 14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids  Academic Article
• Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands  Academic Article
• Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors  Academic Article
• Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain  Academic Article
• Crystal structures of the free and liganded form of an esterolytic catalytic antibody  Academic Article
• Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor  Academic Article
• Crystal structures of the metal-dependent 2-dehydro-3-deoxy-galactarate aldolase suggest a novel reaction mechanism  Academic Article
• Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic e. Coil and enteropathogenic y. Pseudotuberculosis  Academic Article
• Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake  Academic Article
• Crystal structures of transhydrogenase domain i with and without bound nadh  Academic Article
• Crystal structures of two I-A(d)-peptide complexes reveal that high affinity can be achieved without large anchor residues  Academic Article
• Crystal structures of two novel dye-decolorizing peroxidases reveal a β-barrel fold with a conserved heme-binding motif  Academic Article
• Crystal structures of two rat mhc class ia (rt1-a) molecules that are associated differentially with peptide transporter alleles tap-a and tap-b  Academic Article
• Crystal structures of two subtype n10 neuraminidase-like proteins from bat influenza a viruses reveal a diverged putative active site  Academic Article
• Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains  Academic Article
• Crystal-structure and mutational analysis of human uracil-DNA glycosylase - structural basis for specificity and catalysis  Academic Article
• Crystal-structure of C-T-C-T-C-G-A-G-A-G - implications for the structure of the Holliday junction  Academic Article
• Crystal-structure of a covalent DNA drug adduct - anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity  Academic Article
• Crystal-structure of an h-2k(b)-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove  Academic Article
• Crystal-structure of murine cyclophilin-c complexed with immunosuppressive drug cyclosporine-a  Academic Article
• Crystal-structure of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f at 2.2 Å resolution  Academic Article
• Crystal-structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch  Academic Article
• Crystal-structure of the human cell-cycle protein ckshs1 - single-domain fold with similarity to kinase n-lobe domain  Academic Article
• Crystal-structure of the principal neutralization site of hiv-1  Academic Article
• Crystal-structures of a schistosomal drug and vaccine target - glutathione-s-transferase from schistosoma-japonica and its complex with the leading antischistosomal drug praziquantel  Academic Article
• Crystal-structures of aconitase with trans-aconitate and nitrocitrate bound  Academic Article
• Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease  Academic Article
• Crystallization and preliminary X-ray analysis of human carbonic anhydrase III  Academic Article
• Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme  Academic Article
• Crystallization and preliminary X-ray crystallographic analysis of CheW from Thermotoga maritima: a coupling protein of CheA and the chemotaxis receptor  Academic Article
• Crystallization and preliminary X-ray crystallographic analysis of Escherichia coli CheA P3 dimerization domain  Academic Article
• Crystallization and preliminary X-ray crystallographic analysis of Thermotoga maritima CheA P3-P4-P5 domains in complex with CheW  Academic Article
• Crystallization and preliminary X-ray diffraction analysis of human adenovirus  Academic Article
• Crystallization and preliminary analysis of a dsdna bacteriophage capsid intermediate: Prohead ii of hk97  Academic Article
• Crystallization and preliminary crystallographic data for class-i deoxyribose-5-phosphate aldolase from escherichia-coli - an application of reverse screening  Academic Article
• Crystallization and preliminary crystallographic data for rab guanine-nucleotide dissociation inhibitor (rabgdi) from bovine brain  Academic Article
• Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in escherichia coli  Academic Article
• Crystallization and preliminary structural studies of a chorismate mutase catalytic antibody complexed with a transition-state analog  Academic Article
• Crystallization and preliminary x-ray analysis of the dsdna bacteriophage hk97 mature empty capsid  Academic Article
• Crystallization and preliminary-x-ray analysis of the cytoplasmic domain of human erythrocyte band-3  Academic Article
• Crystallization of HLA-DR4 fused to an immunodominant collagen ll peptide implicated in rheumatoid arthritis  Academic Article
• Crystallization of a carbamatase catalytic antibody fab fragment and its complex with a transition-state analogue  Academic Article
• Crystallization of adp-ribosyl cyclase from aplysia californica  Academic Article
• Crystallization optimum solubility screening: Using crystallization results to identify the optimal buffer for protein crystal formation  Academic Article
• Crystallizing membrane proteins using lipidic mesophases  Academic Article
• Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG  Academic Article
• Crystallographic analysis of the dsdna bacteriophage hk97 mature empty capsid  Academic Article
• Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 Å resolution  Academic Article
• Crystallographic and biochemical analysis of cocaine-degrading antibody l5a10  Academic Article
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• Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer  Academic Article
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• Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors  Academic Article
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• Electron tunneling in single crystals of Pseudomonas aeruginosa azurins  Academic Article
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• Enantioselective ortho-C-H cross-coupling of diarylmethylamines with organoborons  Academic Article
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• Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo  Academic Article
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• Exploring icosahedral virus structures with VIPER  Academic Article
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• Fibronectin type III domains engineered to bind CD40L: cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of two complexes  Academic Article
• Fine tuning a molecular motor: The location of alternative domains in the drosophila myosin head  Academic Article
• First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G  Academic Article
• Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement  Academic Article
• Flexibility in the ABC transporter MsbA: Alternating access with a twist  Academic Article
• Flipping of alkylated DNA damage bridges base and nucleotide excision repair  Academic Article
• Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase  Academic Article
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• Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing  Academic Article
• Folate binding site of flavin-dependent thymidylate synthase  Academic Article
• Foldamers with heterogeneous backbones  Academic Article
• Folding and particle assembly are disrupted by single-point mutations near the autocatalytic cleavage site of nudaurelia capensis omega virus capsid protein  Academic Article
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• Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)  Academic Article
• Fragment-based discovery of JAK-2 inhibitors  Academic Article
• Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)  Academic Article
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• High-resolution model of the microtubule  Academic Article
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• High-resolution solution structure of the retinoid X receptor DNA-binding domain  Academic Article
• High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin  Academic Article
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• High-resolution structure of a β-peptide bundle  Academic Article
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• Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators  Academic Article
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• Human antibody - fc receptor interactions illuminated by crystal structures  Academic Article
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• Human ckshs2 atomic-structure - a role for its hexameric assembly in cell-cycle control  Academic Article
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• Molecular docking programs successfully predict the binding of a beta-lactamase inhibitory protein to TEM-1 beta-lactamase  Academic Article
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• Structural basis of cell surface receptor recognition by botulinum neurotoxin B  Academic Article
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• Structure determination of naudaurelia capensis omega virus  Academic Article
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• Structure of REV-ERB beta ligand-binding domain bound to a porphyrin antagonist  Academic Article
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• Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 hemagglutinin  Academic Article
• Structure of a classical broadly neutralizing stem antibody in complex with a pandemic h2 hemagglutinin  Academic Article
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• Structure of a dicationic monoimidazole lexitropsin bound to DNA  Academic Article
• Structure of a kinesin microtubule depolymerization machine  Academic Article
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• Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria  Academic Article
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• Structure of the Reston ebolavirus VP30 C-terminal domain  Academic Article
• Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain  Academic Article
• Structure of the apo anti-influenza CH65 Fab  Academic Article
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• Substituting c-jun n-terminal kinase-3 (jnk3) atp-binding site amino acid residues with their p38 counterparts affects binding of jnk- and p38-selective inhibitors  Academic Article
• Substitution of ribonucleotides in the T7 RNA polymerase promoter element  Academic Article
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• Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes  Academic Article
• Sulfite reductase structure at 1.6 Å - evolution and catalysis for reduction of inorganic anions  Academic Article
• Superoxide dismutase from the eukaryotic thermophile alvinella pompejana: Structures, stability, mechanism, and insights into amyotrophic lateral sclerosis  Academic Article
• Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120  Academic Article
• Supramolecular organization of the repetitive backbone unit of the Streptococcus pneumoniae pilus  Academic Article
• Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase  Academic Article
• Symmetrical stabilization of bound Ca2+ ions in a cooperative pair of EF-hands through hydrogen bonding of coordinating water molecules in calbindin D-9k  Academic Article
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• Synthesis and SAR of p38 alpha MAP kinase inhibitors based on heterobicyclic scaffolds  Academic Article
• Synthesis and X-ray analysis of an unprecedented and stable 2-aza-4,4-spirocyclopropacyclohexadienone  Academic Article
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• Synthesis of 1,2- and 1,3-dicarboxylic acids via Pd(II)-catalyzed carboxylation of aryl and vinyl C-H bonds  Academic Article
• Synthesis of 2-substituted polyhydroxytetrahydropyrimidines (n-hydroxy cyclic guanidino-sugars): Transition state mimics of enzymatic glycosidic cleavage  Academic Article
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• Synthesis of functionalized maoecrystal v core structures  Academic Article
• Synthesis of fused indazole ring systems and application to nigeglanine hydrobromide  Academic Article
• Synthesis of substituted dihydrobenzofurans via tandem S(N)Ar/5-exo-trig cyclization  Academic Article
• Synthesis of the mycolactone core by ring-closing metathesis  Academic Article
• Synthesis of the tetracyclic core of exiguaquinol  Academic Article
• Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine  Academic Article
• Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors  Academic Article
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• T-cell receptor structure and tcr complexes  Academic Article
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• The 2.3 Å structure of porcine circovirus 2  Academic Article
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• The 3.2 A resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays  Academic Article
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• The structure of the crispr-associated protein csa3 provides insight into the regulation of the crispr/cas system  Academic Article
• The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism  Academic Article
• The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation  Academic Article
• The structure of the map2k mek6 reveals an autoinhibitory dimer  Academic Article
• The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex  Academic Article
• The structure of the nuclear pore complex  Academic Article
• The structure of the yeast nadh dehydrogenase (ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates  Academic Article
• The structure of tobacco ringspot virus: A link in the evolution of icosahedral capsids in the picornavirus superfamily  Academic Article
• The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux  Academic Article
• The three-dimensional arcitecture of the EJC core  Academic Article
• The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli  Academic Article
• The total synthesis of coleophomones B, C, and D  Academic Article
• The true structures of the vannusals, part 1: Initial forays into suspected structures and intelligence gathering  Academic Article
• The true structures of the vannusals, part 2: Total synthesis and revised structure of vannusal B  Academic Article
• Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase  Academic Article
• Thermodynamic resolution: how do errors in modeled protein structures affect binding affinity predictions?  Academic Article
• Three clusters of conformational states in p450cam reveal a multistep pathway for closing of the substrate access channel  Academic Article
• Three-dimensional model of the human platelet integrin alpha(llb)beta(3) based on electron cryomicroscopy and x-ray crystallography  Academic Article
• Three-dimensional structure of a viral genome-delivery portal vertex  Academic Article
• Three-dimensional structure of brush border myosin-i at similar to 20 Å resolution by electron microscopy and image analysis  Academic Article
• Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin  Academic Article
• Three-dimensional structure of the bacteriophage p22 tail machine  Academic Article
• Three-dimensional structure of the ephb2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition  Academic Article
• Three-dimensional structure of the m-mulv ca protein on a lipid monolayer: A general model for retroviral capsid assembly  Academic Article
• Through-bond/through-space anion relay chemistry exploiting vinylepoxides as bifunctional linchpins  Academic Article
• Time-resolved molecular dynamics of bacteriophage hk97 capsid maturation interpreted by electron cryo-microscopy and x-ray crystallography  Academic Article
• Titanium(IV) isopropoxide mediated synthesis of pyrimidin-4-ones  Academic Article
• Titanium(IV)-mediated tandem deprotection-cyclodehydration of protected cysteine N-amides: biomimetic syntheses of thiazoline- and thiazole-containing heterocycles  Academic Article
• Tm0486 from the hyperthermophilic anaerobe thermotoga maritima is a thiamin-binding protein involved in response of the cell to oxidative conditions  Academic Article
• Topologically linked protein rings in the bacteriophage hk97 capsid  Academic Article
• Total Synthesis of lleabethoxazole, pseudopteroxazole, and seco-pseudopteroxazole  Academic Article
• Total chemical synthesis of enzymatically active human type II secretory phospholipase A2  Academic Article
• Total syntheses of 2,2 '-epi-cytoskyrin a, rugulosin, and the alleged structure of rugulin  Academic Article
• Total synthesis and structural elucidation of azaspiracid-1. Construction of key building blocks for originally proposed structure  Academic Article
• Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product  Academic Article
• Total synthesis and structural revision of antibiotic CJ-16,264  Academic Article
• Total synthesis and structural revision of biyouyanagin B  Academic Article
• Total synthesis and structural revision of vannusals A and B: synthesis of the true structures of vannusals A and B  Academic Article
• Total synthesis of (+/-)- and (-)-actinophyllic acid  Academic Article
• Total synthesis of (+/-)-haouamine A  Academic Article
• Total synthesis of abyssomicin c and atrop-abyssomicin c  Academic Article
• Total synthesis of abyssomicin c, atrop-abyssomicin c, and abyssomicin d: Implications for natural origins of atrop-abyssomicin c  Academic Article
• Total synthesis of chlorofusin, its seven chromophore diastereomers, and key partial structures  Academic Article
• Total synthesis of colombiasin a and determination of its absolute configuration  Academic Article
• Total synthesis of everninomicin 13,384-1 - part 2: Synthesis of the fgha(2) fragment  Academic Article
• Total synthesis of hirsutellone B  Academic Article
• Total synthesis of marinomycins A-C  Academic Article
• Total synthesis of piericidin A1 and B1 and key analogues  Academic Article
• Total synthesis of platencin  Academic Article
• Total synthesis of the originally assigned structure of vannusal B  Academic Article
• Total synthesis of vinigrol  Academic Article
• Total synthesis, revised structure, and biological evaluation of biyouyanagin A and analogues thereof  Academic Article
• Toward a chemical mechanism of proton pumping by the B-type cytochrome c oxidases: application of density functional theory to cytochrome ba(3) of Thermus thermophilus  Academic Article
• Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies  Academic Article
• Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies  Academic Article
• Toward understanding the structure and interactions of microtubules and motor proteins  Academic Article
• Towards protein-crystal centering using second-harmonic generation (SHG) microscopy  Academic Article
• Towards structure-based drug design - crystal-structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 Å resolution  Academic Article
• Transcription inactivation through local refolding of the RNA polymerase structure  Academic Article
• Trapping a transition state in a computationally designed protein bottle  Academic Article
• Trapping the dynamic acyl carrier protein in fatty acid biosynthesis  Academic Article
• Triggering and monitoring light-sensing reactions in protein crystals  Academic Article
• Trypsin inhibitors for the treatment of pancreatitis  Academic Article
• Tryptophan-accelerated electron flow through proteins  Academic Article
• Tuning assembly size in peptide-based supramolecular polymers by modulation of subunit association affinity  Academic Article
• Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (h-nox) domain  Academic Article
• Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope  Academic Article
• Two conformations of RNA polymerase II revealed by electron crystallography  Academic Article
• Two conformations of a crystalline human tRNA synthetase–tRNA complex: implications for protein synthesis  Academic Article
• Two different, highly exposed, bulged structures for an unusually long peptide bound to rat mhc class i rt1-a(a)  Academic Article
• Two novel SOD1 mutations in patients with familial amyotrophic lateral sclerosis  Academic Article
• Two-dimensional crystallization of streptavidin: In pursuit of the molecular origins of structure, morphology, and thermodynamics  Academic Article
• Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin  Academic Article
• Type iv pilus structure and bacterial pathogenicity  Academic Article
• Type iv pilus structure by cryo-electron microscopy and crystallography: Implications for pilus assembly and functions  Academic Article
• Type-4 pilus-structure: Outside to inside and top to bottom - a minireview  Academic Article
• Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2N-SH2-domain phosphotyrosine-peptide binding cleft  Academic Article
• Tyrosine kinase 2-mediated signal transduction in T lymphocytes is blocked by pharmacological stabilization of Its pseudokinase domain  Academic Article
• UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries  Academic Article
• Ultrahigh and high resolution structures and mutational analysis of monomeric streptococcus pyogenes speb reveal a functional role for the glycine-rich c-terminal loop  Academic Article
• Ultrahigh resolution and full-length pilin structures with insights for filament assembly, pathogenic functions, and vaccine potential  Academic Article
• Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation  Academic Article
• Understanding GFP chromophore biosynthesis: Controlling backbone cyclization and modifying post-translational chemistry  Academic Article
• Understanding GFP posttranslational chemistry: Structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation  Academic Article
• Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1  Academic Article
• Understanding the mechanism of H(+)-induced demetalation as a design strategy for robust iron(III) peroxide-activating catalysts  Academic Article
• Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome  Academic Article
• Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase  Academic Article
• Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor  Academic Article
• Unique domain appended to vertebrate tRNA synthetase is essential for vascular development  Academic Article
• Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange  Academic Article
• Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin  Academic Article
• Unnatural amino acid mutagenesis of fluorescent proteins  Academic Article
• Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease iv  Academic Article
• Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein lb  Academic Article
• Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase  Academic Article
• Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects  Academic Article
• Uranyl ion coordination with rigid aromatic carboxylates and structural characterization of their complexes  Academic Article
• Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1  Academic Article
• Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1 beta  Academic Article
• Using AutoDock for ligand-receptor docking  Academic Article
• Using a quasi-parallel x-ray beam of ultrashort wavelength for high-pressure virus crystallography: Implications for standard macromolecular crystallography  Academic Article
• Using antibodies to perturb the coordination sphere of a transition metal complex  Academic Article
• Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors  Academic Article
• Versatile approach for the synthesis of novel seven-membered iminocyclitols via ring-closing metathesis dihydroxylation reaction  Academic Article
• Versatile approaches for the synthesis of fused-ring γ-lactones utilizing cyclopropane intermediates  Academic Article
• Vinculin activation by talin through helical bundle conversion  Academic Article
• Vinculin binding in its closed conformation by a helix addition mechanism  Academic Article
• Virtual screening against acetylcholine binding protein  Academic Article
• Virus maturation involving large subunit rotations and local refolding  Academic Article
• Virus-like particles of a fish nodavirus display a capsid subunit domain organization different from that of insect nodaviruses  Academic Article
• Visualization of macromolecular structures  Academic Article
• Water--more than just a green solvent: a stereoselective one-pot access to all-chiral tetrahydronaphthalenes in aqueous media  Academic Article
• Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets  Academic Article
• Why does TNA cross-pair more strongly with RNA than with DNA? An answer from X-ray analysis  Academic Article
• Wrn exonuclease structure and molecular mechanism imply an editing role in DNA end processing  Academic Article
• X-ray crystal structure of the cytochrome p450 2b4 active site mutant f297a in complex with clopidogrel: Insights into compensatory rearrangements of the binding pocket  Academic Article
• X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli  Academic Article
• X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase  Academic Article
• X-ray crystallographic determination of the structure of the influenza c virus haemagglutinin-esterase-fusion glycoprotein  Academic Article
• X-ray diffraction analysis of a crystal of HscA from Escherichia coli  Academic Article
• X-ray solution scattering (saxs) combined with crystallography and computation: Defining accurate macromolecular structures, conformations and assemblies in solution  Academic Article
• X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus  Academic Article
• X-ray structure of emre supports dual topology model  Academic Article
• X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease  Academic Article
• X-ray structure of influenza virus NS1 effector domain  Academic Article
• X-ray structure of junctional adhesion molecule: Structural basis for homophilic adhesion via a novel dimerization motif  Academic Article
• X-ray structures of the LXRα LBD in its homodimeric form and implications for heterodimer signaling  Academic Article
• X-ray structures of the hexameric building block of the HIV capsid  Academic Article
• Xiap induces nf-kappa b activation via the bir1/tab1 interaction and bir1 dimerization  Academic Article
• Xol-1, primary determinant of sexual fate in c. Elegans, is a ghmp kinase family member and a structural prototype for a class of developmental regulators  Academic Article
• Xpd helicase structures and activities: Insights into the cancer and aging phenotypes from xpd mutations  Academic Article
• Xrcc4 protein interactions with xrcc4-like factor (xlf) create an extended grooved scaffold for DNA ligation and double strand break repair  Academic Article
• Yatakemycin: Total synthesis, DNA alkylation, and biological properties  Academic Article
• Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB  Academic Article
• alpha-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain  Academic Article
• gamma H2A binds Brc1 to maintain genome integrity during S-phase  Academic Article
• gp41: HIV's shy protein  Academic Article
• p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses  Academic Article
• tRNA structure goes from L to lambda  Academic Article
• tRNA-controlled nuclear import of a human tRNA synthetase  Academic Article
• αβ T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization  Academic Article