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  • 2,6-diamino-5,8-diaza-7,9-dicarba-purine  Academic Article
  • "Chiral amnesia" as a driving force for solid-phase homochirality  Academic Article
  • ... The tyranny of the lattice  Academic Article
  • 1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): a potent, orally bioavailable, and short-duration growth hormone secretagogue  Academic Article
  • 1.35 and 2.07 a resolution structures of the red abalone sperm lysin monomer and dimer reveal features involved in receptor binding  Academic Article
  • 1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore  Academic Article
  • 2,5-diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3)  Academic Article
  • 2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations  Academic Article
  • 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor  Academic Article
  • 2-Amino- 1,2,4 triazolo 1,5-a pyridines as JAK2 inhibitors  Academic Article
  • 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution  Academic Article
  • 2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy  Academic Article
  • 3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle  Academic Article
  • 3,5-disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors  Academic Article
  • 3D domain swapping modulates the stability of members of an icosahedral virus group  Academic Article
  • 4-Aminoindazolyl-dihydrofuro 3,4-d pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase  Academic Article
  • 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency  Academic Article
  • A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model  Academic Article
  • A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton  Academic Article
  • A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from trypanosoma brucei  Academic Article
  • A chemical genomic analysis of decoquinate, a plasmodium falciparum cytochrome b inhibitor  Academic Article
  • A comparative analysis of the immunological evolution of antibody 28B4  Academic Article
  • A comparison of the atomic model of F-actin with cryo-electron micrographs of actin and decorated actin  Academic Article
  • A computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells  Academic Article
  • A concise asymmetric total synthesis of aspidophytine  Academic Article
  • A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies  Academic Article
  • A conservative isoleucine to leucine mutation causes major rearrangements and cold sensitivity in KlenTaq1 DNA polymerase  Academic Article
  • A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis  Academic Article
  • A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from bacteroides thetaiotaomicron at 2.2 A resolution  Academic Article
  • A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant  Academic Article
  • A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome  Academic Article
  • A density functional evaluation of an Fe(III)-Fe(IV) model diiron cluster: comparisons with ribonucleotide reductase intermediate X  Academic Article
  • A discovery strategy for selective inhibitors of c-Src in complex with the focal adhesion kinase SH3/SH2-binding region  Academic Article
  • A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis  Academic Article
  • A dynamic structural model of expanded RNA CAG repeats: A refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations  Academic Article
  • A fence-like coat for the nuclear pore membrane  Academic Article
  • A fluorinated ligand enables room-temperature and regioselective Pd-catalyzed fluorination of aryl triflates and bromides  Academic Article
  • A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking  Academic Article
  • A functional hot spot for antigen recognition in a superagonist TCR/MHC complex  Academic Article
  • A genetically encoded diazirine photocrosslinker in Escherichia coli  Academic Article
  • A glutamate switch controls voltage-sensitive phosphatase function  Academic Article
  • A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase  Academic Article
  • A helix replacement mechanism directs metavinculin functions  Academic Article
  • A heterocyclic peptide nanotube  Academic Article
  • A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV  Academic Article
  • A highly conserved neutralizing epitope on group 2 influenza a viruses  Academic Article
  • A highly diastereo- and enantioselective synthesis of multisubstituted cyclopentanes with four chiral carbons by the organocatalytic domino Michael-Henry reaction  Academic Article
  • A highly effective nonpolar isostere of deoxyguanosine: synthesis, structure, stacking, and base pairing  Academic Article
  • A highly stereoselective organocatalytic tandem aminoxylation/aza-Michael reaction for the synthesis of tetrahydro-1,2-oxazines  Academic Article
  • A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol  Academic Article
  • A human-infecting H10N8 influenza virus retains a strong preference for avian-type receptors  Academic Article
  • A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein  Academic Article
  • A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes - crystal structure of human leukocyte antigen (hla)-a1-mage-a1 in complex with fab-hyb3  Academic Article
  • A maltose-binding protein fusion construct yields a robust crystallography platform for MCL1  Academic Article
  • A molecular dynamics simulation study of segment B1 of protein G  Academic Article
  • A molecular switch regulating transcriptional repression and activation of PPARγ  Academic Article
  • A mutational study of a Diels-Alderase catalytic antibody  Academic Article
  • A new functional domain of guanine nucleotide dissociation inhibitor (alpha-gdi) involved in rab recycling  Academic Article
  • A new method for the stereoselective synthesis of α- and β-glycosylamines using the burgess reagent  Academic Article
  • A new regulatory switch in a JAK protein kinase  Academic Article
  • A nonself sugar mimic of the hiv glycan shield shows enhanced antigenicity  Academic Article
  • A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies  Academic Article
  • A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A  Academic Article
  • A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase  Academic Article
  • A novel cryoprotection scheme for enhancing the diffraction of crystals of recombinant cytochrome ba3 oxidase from thermus thermophilus  Academic Article
  • A novel in silico approach to drug discovery via computational intelligence  Academic Article
  • A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase  Academic Article
  • A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA  Academic Article
  • A peptide inhibitor of hiv-1 neutralizing antibody 2g12 is not a structural mimic of the natural carbohydrate epitope on gp120  Academic Article
  • A peptide that antagonizes tcr-mediated reactions with both syngeneic and allogeneic agonists: Functional and structural aspects  Academic Article
  • A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield  Academic Article
  • A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke  Academic Article
  • A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin  Academic Article
  • A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state  Academic Article
  • A remarkable ring contraction en route to the chartelline alkaloids  Academic Article
  • A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: Crystal structure of spo0f from bacillus subtilis  Academic Article
  • A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases  Academic Article
  • A shared structural solution for neutralizing ebolaviruses  Academic Article
  • A simple strategy towards membrane protein purification and crystallization  Academic Article
  • A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure  Academic Article
  • A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region  Academic Article
  • A small molecule RAS-mimetic disrupts RAS association with effector proteins to block signaling  Academic Article
  • A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor  Academic Article
  • A stereoselective hydroamination transform to access polysubstituted indolizidines  Academic Article
  • A structural basis for the regulatory inactivation of DnaA  Academic Article
  • A structural framework for deciphering the link between I-A(g7) and autoimmune diabetes  Academic Article
  • A structural model for the prostate disease marker, human prostate-specific antigen  Academic Article
  • A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states  Academic Article
  • A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union  Academic Article
  • A structured RNA motif locks Argonaute2:miR-122 onto the 5' end of the HCV genome  Academic Article
  • A substrate mimic allows high-throughput assay of the FabA protein and consequently the identification of a novel inhibitor of pseudomonas aeruginosa FabA  Academic Article
  • A surface on the androgen receptor that allosterically regulates coactivator binding  Academic Article
  • A synthesis of the carbon skeleton of maoecrystal v  Academic Article
  • A synthetic receptor for choline and carnitine  Academic Article
  • A t14c variant of azotobacter vinelandii ferredoxin i undergoes facile 3fe-4s degrees to 4fe-4s (2+) conversion in vitro but not in vivo  Academic Article
  • A total synthesis trilogy: Calicheamicin gamma 1i, taxol (r), and brevetoxin a  Academic Article
  • A weak attractive interaction between organic fluorine and an amide group  Academic Article
  • AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin  Academic Article
  • ALG-2 divalent-ion affinity: Calorimetric analysis of the des23 versions reveals high-affinity site for Mg2+  Academic Article
  • ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization  Academic Article
  • ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase  Academic Article
  • ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling  Academic Article
  • Abalone lysin: The dissolving and evolving sperm protein  Academic Article
  • Acceleration of nucleophilic ch activation by strongly basic solvents  Academic Article
  • Acidophilic adaptations in the structure of Acetobacter aceti N-5-carboxyaminoimidazole ribonucleotide mutase (PurE)  Academic Article
  • Actin crystal dynamics: structural implications for F-actin nucleation, polymerization, and branching mediated by the anti-parallel dimer  Academic Article
  • Active and alkylated human agt structures: A novel zinc site, inhibitor and extrahelical base binding  Academic Article
  • Active and inhibited human catalase structures: Ligand and nadph binding and catalytic mechanism  Academic Article
  • Active site binding modes of curcumin in HIV-1 protease and integrase  Academic Article
  • Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations  Academic Article
  • Active-site and oligosaccharide recognition residues of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f  Academic Article
  • Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2  Academic Article
  • Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans  Academic Article
  • Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes  Academic Article
  • Agonist-bound structure of the human P2Y(12) receptor  Academic Article
  • Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence  Academic Article
  • Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition  Academic Article
  • Alexander Rich (1924-2015)  Academic Article
  • Alkyltransferase-like protein (atl1) distinguishes alkylated guanines for DNA repair using cation-pi interactions  Academic Article
  • Allosteric communication in the dynein motor domain  Academic Article
  • Allosteric inhibition of human ribonucleotide reductase by dATP entails the stabilization of a hexamer  Academic Article
  • Allosteric inhibition of hypoxia inducible factor-2 with small molecules  Academic Article
  • Allosteric inhibition via R-state destabilization in ATP sulfurylase from Penicillium chrysogenum  Academic Article
  • Altering substrate specificity at the heme edge of cytochrome c peroxidase  Academic Article
  • Alternative conformations of a nucleic acid four-way junction  Academic Article
  • Amino acid substitution at the dimeric interface of human manganese superoxide dismutase  Academic Article
  • An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain  Academic Article
  • An EB1-binding motif acts as a microtubule tip localization signal  Academic Article
  • An S(N)Ar approach to sterically hindered ortho-alkoxybenzaldehydes for the synthesis of olefin metathesis catalysts  Academic Article
  • An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide  Academic Article
  • An alpha beta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex  Academic Article
  • An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode  Academic Article
  • An antagonist peptide epo receptor complex suggests that receptor dimerization is not sufficient for activation  Academic Article
  • An antibody CDR3-erythropoietin fusion protein  Academic Article
  • An antibody exo Diels-Alderase inhibitor complex at 1.95 Å resolution  Academic Article
  • An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket  Academic Article
  • An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasome  Academic Article
  • An automated procedure for detecting protein folds from sub-nanometer resolution electron density  Academic Article
  • An efficient platform for screening expression and crystallization of glycoproteins produced in human cells  Academic Article
  • An electrostatic mechanism for Ca2+ -mediated regulation of gap junction channels  Academic Article
  • An enantioselective synthesis of insecticidal 4-alkynyloxazolines  Academic Article
  • An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured  Academic Article
  • An escherichia coli-based cell-free system for large-scale production of functional mammalian membrane proteins suitable for x-ray crystallography  Academic Article
  • An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity  Academic Article
  • An expedient synthesis of a functionalized core structure of bielschowskysin  Academic Article
  • An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging  Academic Article
  • An insight into the interaction mode between CheB and chemoreceptor from two crystal structures of CheB methylesterase catalytic domain  Academic Article
  • An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity  Academic Article
  • An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance  Academic Article
  • An online resource for GPCR structure determination and analysis  Academic Article
  • An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution  Academic Article
  • An unexpected outcome of surface engineering an integral membrane protein: Improved crystallization of cytochrome ba(3) from thermus thermophilus  Academic Article
  • An unexpected twist in viral capsid maturation  Academic Article
  • An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer  Academic Article
  • An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene  Academic Article
  • An α/β-peptide helix bundle with a pure β3-amino acid core and a distinctive quaternary structure  Academic Article
  • Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise  Academic Article
  • Analysis of hapten binding and catalytic determinants in a family of catalytic antibodies  Academic Article
  • Analysis of the class i aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99 Å resolution  Academic Article
  • Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase  Academic Article
  • Ancient tRNA synthetase meets modern structural biology  Academic Article
  • Anion-exchange-triggered 1,3-shift of an NH proton to iridium in protic n-heterocyclic carbenes: Hydrogen-bonding and ion-pairing effects  Academic Article
  • Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres  Academic Article
  • Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike  Academic Article
  • Antibody 2g12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the hiv-1 glycan shield if domain exchanged  Academic Article
  • Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike  Academic Article
  • Antibody binding defines a structure for an epitope that participates in the prpc -> prpsc conformational change  Academic Article
  • Antibody catalysis of the oxidation of water  Academic Article
  • Antibody domain exchange is an immunological solution to carbohydrate cluster recognition  Academic Article
  • Antibody modeling assessment II. Structures and models  Academic Article
  • Antibody recognition of a highly conserved influenza virus epitope  Academic Article
  • Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site  Academic Article
  • Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation  Academic Article
  • Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation  Academic Article
  • Antifungal azoles: structural insights into undesired tight binding to cholesterol-metabolizing CYP46A1  Academic Article
  • Antigen recognition by variable lymphocyte receptors  Academic Article
  • Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic  Academic Article
  • Apo raver1 structure reveals distinct RRM domain orientations  Academic Article
  • Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network  Academic Article
  • Architecture of the Soluble Receptor Aer2 Indicates an In-Line Mechanism for PAS and HAMP Domain Signaling  Academic Article
  • Architecture of the complex formed by large and small terminase subunits from bacteriophage P22  Academic Article
  • Architecture of the flagellar rotor  Academic Article
  • Architecture of the mediator head module  Academic Article
  • Architectures of lipid transport systems for the bacterial outer membrane  Academic Article
  • Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor  Academic Article
  • Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein  Academic Article
  • Arylation of rhodium(II) azavinyl carbenes with boronic acids  Academic Article
  • Asia growth in membrane protein structure  Academic Article
  • Assembly of acanthamoeba myosin-ii minifilaments. Model of anti-parallel dimers based on em and x-ray diffraction of 2d and 3d crystals  Academic Article
  • Assembly states of FliM and FliG within the flagellar switch complex  Academic Article
  • Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure  Academic Article
  • Asymmetric electrophilic fluorocyclization with carbon nucleophiles  Academic Article
  • Asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI)  Academic Article
  • Asymmetric synthesis of pochonin E and F, revision of their proposed structure, and their conversion to potent Hsp90 inhibitors  Academic Article
  • Asymmetric synthesis of quaternary alpha- and beta-amino acids and beta-lactams via proline-catalyzed mannich reactions with branched aldehyde donors  Academic Article
  • Atl1 regulates choice between global genome and transcription-coupled repair of o-6-alkylguanines  Academic Article
  • Atomic and residue hydrophilicity in the context of folded protein structures  Academic Article
  • Atomic structure of the 75 MDa extremophile Sulfolobus turreted icosahedral virus determined by CryoEM and X-ray crystallography  Academic Article
  • Atomic-level modelling of the HIV capsid  Academic Article
  • AutoDock4(Zn): an improved AutoDock force field for small-molecule docking to zinc metalloproteins  Academic Article
  • AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery  Academic Article
  • Automated docking of ligands to an artificial active site: augmenting crystallographic analysis with computer modeling  Academic Article
  • Automated identification of functional dynamic contact networks from X-ray crystallography  Academic Article
  • Automated sample mounting and alignment system for biological crystallography at a synchrotron source  Academic Article
  • Automated three-dimensional reconstruction of keyhole limpet hemocyanin type 1  Academic Article
  • Automation of x-ray crystallography  Academic Article
  • Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential  Academic Article
  • Azotobacter-vinelandii ferredoxin-i - alteration of individual surface-charges and the 4fe-4s (2+/+) cluster reduction potential  Academic Article
  • Azotobacter-vinelandii ferredoxin-i - aspartate-15 facilitates proton-transfer to the reduced 3fe-4s cluster  Academic Article
  • Azurin as a protein scaffold for a low-coordinate nonheme iron site with a small-molecule binding pocket  Academic Article
  • Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins  Academic Article
  • Bacterial pleckstrin homology domains: A prokaryotic origin for the PH domain  Academic Article
  • Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery  Academic Article
  • Base excision repair enzyme family portrait: Integrating the structure and chemistry of an entire DNA repair pathway  Academic Article
  • Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA  Academic Article
  • Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain  Academic Article
  • Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis, evaluation, and mechanism of action  Academic Article
  • Biggest virus molecular structure yet!  Academic Article
  • Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures  Academic Article
  • Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51  Academic Article
  • Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors  Academic Article
  • Biochemical characterization and crystal structure of a dim1 family associated protein: Dim2  Academic Article
  • Biochemical characterization and structural analysis of a highly proficient cocaine esterase  Academic Article
  • Biogenesis of the secretory granule: Chromogranin a coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation  Academic Article
  • Biomimetic synthesis of antimalarial naphthoquinones  Academic Article
  • Biophysical characterization of a β-peptide bundle: Comparison to natural proteins  Academic Article
  • Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation  Academic Article
  • Bistable cucurbituril rotaxanes without stoppers  Academic Article
  • Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from naja atra venom that targets the BKCa channel  Academic Article
  • Blu-ice and the distributed control system: Software for data acquisition and instrument control at macromolecular crystallography beamlines  Academic Article
  • Blue-fluorescent antibodies  Academic Article
  • Breaking cryo-EM resolution barriers to facilitate drug discovery  Academic Article
  • Breaking the low barrier hydrogen bond in a serine protease  Academic Article
  • Broadly neutralizing anti-hiv antibody 4e10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41  Academic Article
  • Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans  Academic Article
  • Broken symmetry DFT calculations/analysis for oxidized and reduced dinuclear center in cytochrome c oxidase: relating structures, protonation states, energies, and Mössbauer properties in ba3 thermus thermophilus  Academic Article
  • Brush border myosin-i structure and adp-dependent conformational changes revealed by cryoelectron microscopy and image analysis  Academic Article
  • C-2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and hiv/fiv proteases  Academic Article
  • Calculations of electrostatic interactions and pK(a)s in the active site of Escherichia coli thioredoxin  Academic Article
  • Capsid conformational sampling in HK97 maturation visualized by X-ray crystallography and cryo-EM  Academic Article
  • Carbon-deuterium bonds as probes of dihydrofolate reductase  Academic Article
  • Carbonic anhydrase inhibitors. Interaction of 2-n,n-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: Kinetic and x-ray crystallographic studies  Academic Article
  • Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: Crystal structures of abzyme 21D8  Academic Article
  • Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: Insertion of valine Cγ into the substrate access channel  Academic Article
  • Catalytic antibodies - structure and function  Academic Article
  • Catalytic asymmetric formal [4 + 1] annulation leading to optically active cis-isoxazoline N-oxides  Academic Article
  • Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A  Academic Article
  • Cavitand-porphyrins  Academic Article
  • Cbp/p300 taz1 domain forms a structured scaffold for ligand binding  Academic Article
  • Changes in active site histidine hydrogen bonding trigger cryptochrome activation  Academic Article
  • Characterization and inactivation of an agmatine deiminase from helicobacter pylori  Academic Article
  • Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode  Academic Article
  • Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site  Academic Article
  • Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry  Academic Article
  • Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro  Academic Article
  • Characterization of the electrophile binding site and substrate binding mode of the 26-kda glutathione s-transferase from schistosoma japonicum  Academic Article
  • Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain  Academic Article
  • Characterization of y122f r2 of escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and x-ray crystallography  Academic Article
  • Characterizing flexible and intrinsically unstructured biological macromolecules by sas using the porod-debye law  Academic Article
  • Charting a path to success in virtual screening  Academic Article
  • Chasing molecules that were never there: Misassigned natural products and the role of chemical synthesis in modern structure elucidation  Academic Article
  • Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis  Academic Article
  • Chemical modification of viruses and virus-like particles  Academic Article
  • Chemical tools for studying the impact of cis/trans prolyl isomerization on signaling: a case study on RNA polymerase II phosphatase activity and specificity  Academic Article
  • Chemical tools to decipher regulation of phosphatases by proline isomerization on eukaryotic RNA polymerase II  Academic Article
  • Chemoenzymatic synthesis of GDP-L-fucose and the Lewis X glycan derivatives  Academic Article
  • Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environment  Academic Article
  • Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma  Academic Article
  • Chemotype-selective modes of action of κ-opioid receptor agonists  Academic Article
  • Cheshift-2 resolves a local inconsistency between two x-ray crystal structures  Academic Article
  • Chimeragenesis of distantly-related proteins by noncontiguous recombination  Academic Article
  • Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes  Academic Article
  • Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype A protease  Academic Article
  • Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction  Academic Article
  • Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7)  Academic Article
  • Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase  Academic Article
  • Closely related antibody receptors exploit fundamentally different strategies for steroid recognition  Academic Article
  • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus  Academic Article
  • Co-folding of a FliF-FliG split domain forms the basis of the MS:C ring interface within the bacterial flagellar motor  Academic Article
  • Coaxing a pyridine nucleus to give up its aromaticity: synthesis and pharmacological characterization of novel conformationally restricted analogues of nicotine and anabasine  Academic Article
  • Cofactor-containing antibodies: Crystal structure of the original yellow antibody  Academic Article
  • Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution  Academic Article
  • Combinatorial crystallization of an rna-protein complex  Academic Article
  • Combined microspectrophotometric and crystallographic examination of chemically reduced and x-ray radiation-reduced forms of cytochrome ba(3) oxidase from thermus thermophilus: Structure of the reduced form of the enzymes  Academic Article
  • Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the gamma delta t-cell ligand t10  Academic Article
  • Combining h/d exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase  Academic Article
  • Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008  Academic Article
  • Comparative structural analysis of a novel glutathione S-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 Å resolution  Academic Article
  • Comparative studies of T=3 and T=4 icosahedral RNA insect viruses  Academic Article
  • Comparison of NMR and crystal structures for the proteins TM1112 and TM1367  Academic Article
  • Comparison of NMR and crystal structures highlights conformational isomerism in protein active sites  Academic Article
  • Complementary approaches to structure determination of icosahedral viruses  Academic Article
  • Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer  Academic Article
  • Complete structural model of Escherichia coli RNA polymerase from a hybrid approach  Academic Article
  • Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold  Academic Article
  • Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic hiv vaccine epitope  Academic Article
  • Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope  Academic Article
  • Computational fragment-based binding site identification by ligand competitive saturation  Academic Article
  • Computational protein design using flexible backbone remodeling and resurfacing: case studies in structure-based antigen design  Academic Article
  • Conformational adaptation of human cytochrome p450 2b6 and rabbit cytochrome p450 2b4 revealed upon binding multiple amlodipine molecules  Academic Article
  • Conformational analysis of galanin using end to end distance distribution observed by Förster resonance energy transfer  Academic Article
  • Conformational change in the nadp(h) binding domain of transhydrogenase defines four states  Academic Article
  • Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: A possible inhibition mechanism for the key enzyme in polymyxin resistance  Academic Article
  • Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: implications for enzyme mechanism  Academic Article
  • Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas Campestris pv. Campestris  Academic Article
  • Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency  Academic Article
  • Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding  Academic Article
  • Conformational diversity in nad(h) and interacting transhydrogenase nicotinamide nucleotide binding domains  Academic Article
  • Conformational flexibility in crystal structures of human 11 β-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation  Academic Article
  • Conformational flexibility in the flap domains of ligand-free HIV protease  Academic Article
  • Conformational flexibility of b-DNA at 0.74 Å resolution: D(ccagtactgg)(2)  Academic Article
  • Conformational flexibility underlies ubiquitin ligation mediated by the WWP1HECT domain E3 ligase  Academic Article
  • Conformational heterogeneity and the affinity of substrate molecular recognition by cytochrome P450cam  Academic Article
  • Conformational isomerism can limit antibody catalysis  Academic Article
  • Conformational polymorphism of cyclosporine-a  Academic Article
  • Conformational states of cytochrome p450cam revealed by trapping of synthetic molecular wires  Academic Article
  • Conformational switching in the fungal light sensor vivid  Academic Article
  • Conformational transitions that enable histidine kinase autophosphorylation and receptor array integration  Academic Article
  • Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: Receptor-selective somatostatin analogues  Academic Article
  • Conquer by cryo-EM without physically dividing  Academic Article
  • Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors  Academic Article
  • Conserved binding mode of human beta(2) adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography  Academic Article
  • Conserved glycine 232 in the ligand channel of ba(3) cytochrome oxidase from Thermus thermophilus  Academic Article
  • Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes  Academic Article
  • Conserved xpb core structure and motifs for DNA unwinding: Implications for pathway selection of transcription or excision repair  Academic Article
  • Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c  Academic Article
  • Construction of highly functionalized medium-sized rings: Synthesis of hyperforin and perforatumone model systems  Academic Article
  • Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system  Academic Article
  • Contrasting IgG structures reveal extreme asymmetry and flexibility  Academic Article
  • Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis  Academic Article
  • Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding  Academic Article
  • Control of four stereocenters in an organocatalytic domino double Michael reaction: Efficient synthesis of multisubstituted cyclopentanes  Academic Article
  • Controlling conformational flexibility of an O(2)-binding H-NOX domain  Academic Article
  • Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis  Academic Article
  • Copper-based pulsed dipolar ESR spectroscopy as a probe of protein conformation linked to disease states  Academic Article
  • Copper-free cycloaddition of azide and alkyne in crystalline state facilitated by arene-perfluoroarene interactions  Academic Article
  • Core structure of the yeast spt4-spt5 complex: A conserved module for regulation of transcription elongation  Academic Article
  • Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies  Academic Article
  • Cortistatin a is a high-affinity ligand of protein kinases rock, cdk8, and cdk11  Academic Article
  • Coupled redox potentials in manganese and iron superoxide dismutases from reaction kinetics and density functional/electrostatics calculations  Academic Article
  • Coupling of hydrogen bonding to chromophore conformation and function in photoactive yellow protein  Academic Article
  • Cross-neutralization of influenza a viruses mediated by a single antibody loop  Academic Article
  • Crosslinking of and coupling to viral capsid proteins by tyrosine oxidation  Academic Article
  • Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function  Academic Article
  • Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer  Academic Article
  • Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome  Academic Article
  • Crystal and solution structures of an HslUV protease-chaperone complex  Academic Article
  • Crystal structure and activity studies of the C11 cysteine peptidase from parabacteroides merdae in the human gut microbiome  Academic Article
  • Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis  Academic Article
  • Crystal structure and modeling of the tetrahedral intermediate state of methylmalonate-semialdehyde dehydrogenase (MMSDH) from Oceanimonas doudoroffii  Academic Article
  • Crystal structure and novel recognition motif of rho adp-ribosylating c3 exoenzyme from clostridium botulinum: Structural insights for recognition specificity and catalysis  Academic Article
  • Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase  Academic Article
  • Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 Å resolution reveals a new fold with a novel active site  Academic Article
  • Crystal structure of 3-hydroxyanthranilic acid 3,4-dioxygenase from saccharomyces cerevisiae: A special subgroup of the type III extradiol dioxygenases  Academic Article
  • Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 Å resolution  Academic Article
  • Crystal structure of ATP sulfurylase from the bacterial symbiont of the hydrothermal vent tubeworm Riftia pachyptila  Academic Article
  • Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism  Academic Article
  • Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: Implications for Lsm ring organisation and recruitment  Academic Article
  • Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif  Academic Article
  • Crystal structure of Marburg virus VP24  Academic Article
  • Crystal structure of Marburg virus VP40 reveals a broad, basic patch for matrix assembly and a requirement of the N-terminal domain for immunosuppression  Academic Article
  • Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis  Academic Article
  • Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 Å resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy3-keto-5-methylthiopentenyl-1-phosphate  Academic Article
  • Crystal structure of NMA 1982 from Neisseria meningiddis at 1.5 Å resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases  Academic Article
  • Crystal structure of NMC-4 fab anti-von Willebrand factor A1 domain  Academic Article
  • Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution  Academic Article
  • Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1  Academic Article
  • Crystal structure of Pasteurella haemolytica ferric ion-binding protein a reveals a novel class of bacterial iron-binding proteins  Academic Article
  • Crystal structure of S-adenosylmethionine : tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold  Academic Article
  • Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1  Academic Article
  • Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue  Academic Article
  • Crystal structure of TM1030 from THermotoga maritima at 2.3 Å resolution reveals molecular details of its transcription repressor function  Academic Article
  • Crystal structure of TM1367 from Thermotoga maritima at 1.90 Å resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold  Academic Article
  • Crystal structure of Trbp111: a structure-specific tRNA-binding protein  Academic Article
  • Crystal structure of UbiX, an aromatic acid decarboxylase from the psychrophilic bacterium Colwellia psychrerythraea that undergoes FMN-induced conformational changes  Academic Article
  • Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3 '-> 2 ') nucleosides: A four-carbon sugar is easily accommodated into the backbone of DNA  Academic Article
  • Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution  Academic Article
  • Crystal structure of a bacterial cocaine esterase  Academic Article
  • Crystal structure of a bifunctional deaminase and reductase from Bacillus subtilis involved in riboflavin biosynthesis  Academic Article
  • Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis  Academic Article
  • Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin  Academic Article
  • Crystal structure of a cocaine-binding antibody  Academic Article
  • Crystal structure of a conserved hypothetical protein (gi : 13879369) from Mouse at 1.90 A resolution reveals a new fold  Academic Article
  • Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution  Academic Article
  • Crystal structure of a divalent metal ion transporter CorA at 2.9 Å resolution  Academic Article
  • Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold  Academic Article
  • Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262  Academic Article
  • Crystal structure of a gamma delta t cell receptor ligand t22: A truncated mhc-like fold  Academic Article
  • Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 Å resolution reveals a new fold  Academic Article
  • Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 Å resolution  Academic Article
  • Crystal structure of a human aminoacyl-tRNA synthetase cytokine  Academic Article
  • Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity  Academic Article
  • Crystal structure of a lipid G protein-coupled receptor  Academic Article
  • Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution  Academic Article
  • Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch  Academic Article
  • Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design  Academic Article
  • Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 Å resolution  Academic Article
  • Crystal structure of a novel archaeal AAA plus ATPase SSO 1545 from Sulfolobus solfataricus  Academic Article
  • Crystal structure of a phosphatase-resistant mutant of sporulation response regulator spo0f from bacillus subtilis  Academic Article
  • Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77 Å resolution  Academic Article
  • Crystal structure of a putative NADPH-dependent oxidoreductase (GI : 18204011) from mouse at 2.10 Å resolution  Academic Article
  • Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2.5 Å resolution  Academic Article
  • Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1.7 Å resolution  Academic Article
  • Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 Å resolution reveals a new fold  Academic Article
  • Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution  Academic Article
  • Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family  Academic Article
  • Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 Å resolution  Academic Article
  • Crystal structure of a shark single-domain antibody v region in complex with lysozyme  Academic Article
  • Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 a resolution  Academic Article
  • Crystal structure of a soluble cleaved HIV-1 envelope trimer  Academic Article
  • Crystal structure of a transcription regulator (TM1602) from Thermotoga maritima at 2.3 Å resolution  Academic Article
  • Crystal structure of a two-subunit TrkA octameric gating ring assembly  Academic Article
  • Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 Å resolution  Academic Article
  • Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 Å resolution  Academic Article
  • Crystal structure of adenosine 5 '-phosphosulfate kinase from Penicillium chrysogenum  Academic Article
  • Crystal structure of an ADP-ribosylated protein with a cytidine deaminase-like fold, but unknown function (TM 1506), from Thermatoga maritima at 2.70 Å resolution  Academic Article
  • Crystal structure of an Apo mRNA decapping enzyme (DcpS) from mouse at 1.83 Å resolution  Academic Article
  • Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3  Academic Article
  • Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 Å resolution  Academic Article
  • Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 Å resolution reveals a fold similar to the Ran-binding protein Mog1p  Academic Article
  • Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 Å resolution  Academic Article
  • Crystal structure of an alanine-glyoxylate aminotransferase from anabaena sp at 1.70 A resolution reveals a noncovalently linked PLP cofactor  Academic Article
  • Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 Å resolution  Academic Article
  • Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 Å resolution  Academic Article
  • Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 Å resolution  Academic Article
  • Crystal structure of an indigoidine synthase A (IndA)-like protein (TM64) from Thermotoga maritima at 1.90 A resolution reveals a new fold  Academic Article
  • Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design  Academic Article
  • Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 Å resolution  Academic Article
  • Crystal structure of an isolated V(alpha) domain of the 2C T-cell receptor  Academic Article
  • Crystal structure of an mhc class i presented glycopeptide that generates carbohydrate-specific ctl  Academic Article
  • Crystal structure of an orphan protein (TM0875) from thermotoga maritima at 2.00 Å resolution reveals a new fold  Academic Article
  • Crystal structure of antagonist bound human lysophosphatidic acid receptor 1  Academic Article
  • Crystal structure of aplysia adp ribosyl cyclase, a homologue of the bifunctional ectozyme cd38  Academic Article
  • Crystal structure of archaeal ribonuclease P protein aRpp29 from Archaeoglobus fulgidus  Academic Article
  • Crystal structure of atp sulfurylase from penicillium chrysogenum: Insights into the allosteric regulation of sulfate assimilation  Academic Article
  • Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening  Academic Article
  • Crystal structure of botulinum neuro-toxin type a and implications for toxicity  Academic Article
  • Crystal structure of botulinum neurotoxin type a in complex with the cell surface co-receptor gt1b - insight into the toxin-neuron interaction  Academic Article
  • Crystal structure of botulinum neurotoxin type g light chain: Serotype divergence in substrate recognition  Academic Article
  • Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor urb597: Discovery of a deacylating water molecule and insight into enzyme inactivation  Academic Article
  • Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5  Academic Article
  • Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 Å resolution  Academic Article
  • Crystal structure of histidine phosphotransfer protein ShpA, an essential regulator of stalk biogenesis in Caulobacter crescentus  Academic Article
  • Crystal structure of homoserine o-succinyltransferase from bacillus cereus at 2.4 Å resolution  Academic Article
  • Crystal structure of hsiuv complexed with a vinyl sulfone inhibitor: Corroboration of a proposed mechanism of allosteric activation of hsiv by hsiu  Academic Article
  • Crystal structure of human adenovirus at 3.5 Å resolution  Academic Article
  • Crystal structure of human antibody 2909 reveals conserved features of quaternary structure-specific antibodies that potently neutralize HIV-1  Academic Article
  • Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition  Academic Article
  • Crystal structure of human cytochrome p450 2d6 with prinomastat bound  Academic Article
  • Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping  Academic Article
  • Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue  Academic Article
  • Crystal structure of human ornithine transcarbamylase complexed with carbamoyl phosphate and L-norvaline at 1.9 A resolution  Academic Article
  • Crystal structure of human seryl-tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes  Academic Article
  • Crystal structure of human toll-like receptor 3 (tlr3) ectodomain  Academic Article
  • Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A  Academic Article
  • Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites  Academic Article
  • Crystal structure of human vinculin  Academic Article
  • Crystal structure of misoprostol bound to the labor inducer prostaglandin E-2 receptor  Academic Article
  • Crystal structure of mouse cd1: An mhc-like fold with a large hydrophobic binding groove  Academic Article
  • Crystal structure of mouse cd1d bound to the self ligand phosphatidylcholine: A molecular basis for nkt cell activation  Academic Article
  • Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (trem-1) at 1.76 Å  Academic Article
  • Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs  Academic Article
  • Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from thermotoga maritima at 1.90 Å resolution  Academic Article
  • Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 Å-resolution  Academic Article
  • Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser  Academic Article
  • Crystal structure of soluble md-1 and its interaction with lipid iva  Academic Article
  • Crystal structure of staphylococcus aureus transglycosylase in complex with a lipid ii analog and elucidation of peptidoglycan synthesis mechanism  Academic Article
  • Crystal structure of tetrameric form of human lysyl-tRNA synthetase: implications for multisynthetase complex formation  Academic Article
  • Crystal structure of the 100 kda arsenite oxidase from alcaligenes faecalis in two crystal forms at 1.64 Å and 2.03 Å  Academic Article
  • Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain  Academic Article
  • Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 Å resolution  Academic Article
  • Crystal structure of the C-terminal domain of mouse TLR9  Academic Article
  • Crystal structure of the DNA-recognition component of the bacterial virus sf6 genome-packaging machine  Academic Article
  • Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution  Academic Article
  • Crystal structure of the Fic (Filamentation induced by cAMP) family protein SO4266 (gi|24375750) from Shewanella oneidensis MR-1 at 1.6 A resolution  Academic Article
  • Crystal structure of the Formin mDia1 in autoinhibited conformation  Academic Article
  • Crystal structure of the Frizzled 4 receptor in a ligand-free state  Academic Article
  • Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose  Academic Article
  • Crystal structure of the N-terminal domains of the surface cell antigen 4 of Rickettsia  Academic Article
  • Crystal structure of the Nipah virus phosphoprotein tetramerization domain  Academic Article
  • Crystal structure of the TCR co-receptor CD8 alpha alpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution  Academic Article
  • Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran  Academic Article
  • Crystal structure of the anti-viral apobec3g catalytic domain and functional implications  Academic Article
  • Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding  Academic Article
  • Crystal structure of the broadly cross-reactive hiv-1-neutralizing fab x5 and fine mapping of its epitope  Academic Article
  • Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine  Academic Article
  • Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin a  Academic Article
  • Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a k(+) channel inhibitor-like fold  Academic Article
  • Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair  Academic Article
  • Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 Å resolution reveals a new fold  Academic Article
  • Crystal structure of the gtpase domain of rat dynamin 1  Academic Article
  • Crystal structure of the human 4-1BB/4-1BBL complex  Academic Article
  • Crystal structure of the human n-myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor  Academic Article
  • Crystal structure of the lactose operon repressor and its complexes with DNA and inducer  Academic Article
  • Crystal structure of the membrane-bound bifunctional transglycosylase pbp1b from escherichia coli  Academic Article
  • Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A  Academic Article
  • Crystal structure of the oligomeric form of Lassa virus matrix protein Z  Academic Article
  • Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of camp-dependent protein kinase  Academic Article
  • Crystal structure of the spindle assembly checkpoint protein Bub3  Academic Article
  • Crystal structure of the transcriptional repressor pagr of bacillus anthracis  Academic Article
  • Crystal structure of the von Willebrand factor A1 domain in complex with the function blocking NMC-4 Fab  Academic Article
  • Crystal structure of the von Willebrand factor modulator botrocetin  Academic Article
  • Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892  Academic Article
  • Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 Å resolution  Academic Article
  • Crystal structure of tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex  Academic Article
  • Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases  Academic Article
  • Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 Å resolution: Self-hydroxylation of phe300 and the pterin-binding site  Academic Article
  • Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2.85 Å resolution  Academic Article
  • Crystal structure of viral macrophage inflammatory protein i encoded by kaposi's sarcoma-associated herpesvirus at 1.7 a  Academic Article
  • Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 Å resolution reveals a new fold  Academic Article
  • Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34  Academic Article
  • Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis  Academic Article
  • Crystal structures of MW1337R and lin2004: Representatives of a novel protein family that adopt a four-helical bundle fold  Academic Article
  • Crystal structures of a quorum-quenching antibody  Academic Article
  • Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP  Academic Article
  • Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine  Academic Article
  • Crystal structures of apolipoprotein(a) kringle iv37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: Existence of novel and expected binding modes  Academic Article
  • Crystal structures of cytochrome p450 2b4 in complex with the inhibitor 1-biphenyl-4-methyl-1h-imidazole: Ligand-induced structural response through alpha-helical repositioning  Academic Article
  • Crystal structures of ferredoxin variants exhibiting large changes in fe-s reduction potential  Academic Article
  • Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases  Academic Article
  • Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR  Academic Article
  • Crystal structures of human HSP90 alpha-complexed with dihydroxyphenylpyrazoles  Academic Article
  • Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates  Academic Article
  • Crystal structures of human immunodeficiency virus type 1 (hiv-1) neutralizing antibody 2219 in complex with three different v3 peptides reveal a new binding mode for hiv-1 cross-reactivity  Academic Article
  • Crystal structures of human topoisomerase i in covalent and noncovalent complexes with DNA  Academic Article
  • Crystal structures of leukotriene a(4) hydrolase in complex with captopril and two competitive tight-binding inhibitors  Academic Article
  • Crystal structures of mouse CD1d-iGb3 complex and its cognate v alpha 14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids  Academic Article
  • Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands  Academic Article
  • Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors  Academic Article
  • Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain  Academic Article
  • Crystal structures of the free and liganded form of an esterolytic catalytic antibody  Academic Article
  • Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor  Academic Article
  • Crystal structures of the metal-dependent 2-dehydro-3-deoxy-galactarate aldolase suggest a novel reaction mechanism  Academic Article
  • Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic e. Coil and enteropathogenic y. Pseudotuberculosis  Academic Article
  • Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake  Academic Article
  • Crystal structures of transhydrogenase domain i with and without bound nadh  Academic Article
  • Crystal structures of two I-A(d)-peptide complexes reveal that high affinity can be achieved without large anchor residues  Academic Article
  • Crystal structures of two novel dye-decolorizing peroxidases reveal a β-barrel fold with a conserved heme-binding motif  Academic Article
  • Crystal structures of two rat mhc class ia (rt1-a) molecules that are associated differentially with peptide transporter alleles tap-a and tap-b  Academic Article
  • Crystal structures of two subtype n10 neuraminidase-like proteins from bat influenza a viruses reveal a diverged putative active site  Academic Article
  • Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains  Academic Article
  • Crystal-structure and mutational analysis of human uracil-DNA glycosylase - structural basis for specificity and catalysis  Academic Article
  • Crystal-structure of C-T-C-T-C-G-A-G-A-G - implications for the structure of the Holliday junction  Academic Article
  • Crystal-structure of a covalent DNA drug adduct - anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity  Academic Article
  • Crystal-structure of an h-2k(b)-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove  Academic Article
  • Crystal-structure of murine cyclophilin-c complexed with immunosuppressive drug cyclosporine-a  Academic Article
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  • Crystallographic analysis of the dsdna bacteriophage hk97 mature empty capsid  Academic Article
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  • Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli  Academic Article
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  • Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors  Academic Article
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  • Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics  Academic Article
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  • Design of activated serine-containing catalytic triads with atomic-level accuracy  Academic Article
  • Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site  Academic Article
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  • Design of potent and selective 2-aminobenzimidazole-based p38 alpha MAP kinase inhibitors with excellent in vivo efficacy  Academic Article
  • Design, synthesis and SAR of novel glucokinase activators  Academic Article
  • Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors  Academic Article
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  • Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists  Academic Article
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  • Designing sequence to control protein function in an EF-hand protein  Academic Article
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  • Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors  Academic Article
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  • Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor  Academic Article
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  • Development of thioquinazolinones, allosteric Chk1 kinase inhibitors  Academic Article
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  • Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2  Academic Article
  • Discovery and optimization of a series of pyrimidine-based phosphodiesterase 10A (PDE10A) inhibitors through fragment screening, structure-based design, and parallel synthesis  Academic Article
  • Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors  Academic Article
  • Discovery of 5-azaindazole (GNE-955) as a potent pan-pim inhibitor with optimized bioavailability  Academic Article
  • Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system  Academic Article
  • Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering  Academic Article
  • Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV  Academic Article
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  • Discovery of a noncovalent, mutant-selective epidermal growth factor receptor inhibitor  Academic Article
  • Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer  Academic Article
  • Discovery of a selective covalent inhibitor of lysophospholipase-like 1 (LYPLAL1) as a tool to evaluate the role of this serine hydrolase in metabolism  Academic Article
  • Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists  Academic Article
  • Discovery of different types of inhibition between the human and Thermotoga maritima alpha-fucosidases by fuconojirimycin-based derivatives  Academic Article
  • Discovery of fragment-derived small molecules for in vivo inhibition of ketohexokinase (KHK)  Academic Article
  • Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design  Academic Article
  • Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators  Academic Article
  • Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors  Academic Article
  • Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design  Academic Article
  • Discovery of potent and bioavailable GSK-3β inhibitors  Academic Article
  • Discovery of potent and selective covalent inhibitors of JNK  Academic Article
  • Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists  Academic Article
  • Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation  Academic Article
  • Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK)  Academic Article
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  • Distributed automated docking of flexible ligands to proteins: parallel applications of AutoDock 2.4  Academic Article
  • Disulfide bond stabilization of the hexameric capsomer of human immunodeficiency virus  Academic Article
  • Divergent evolution of protein conformational dynamics in dihydrofolate reductase  Academic Article
  • Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors  Academic Article
  • Division of labor in transhydrogenase by alternating proton translocation and hydride transfer  Academic Article
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  • Dynamic kinetic asymmetric transfer hydrogenation of racemic 2,4-diaryl-2,3-dihydrobenzo[b][1,4]diazepines catalyzed by chiral phosphoric acids  Academic Article
  • Dynamics of a flexible loop in dihydrofolate-reductase from escherichia-coli and its implication for catalysis  Academic Article
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  • Efficient access to the core of the Strychnos, Aspidosperma and Iboga alkaloids. A short synthesis of norfluorocurarine  Academic Article
  • Efficient synthesis of 2-substituted-1,2,3-triazoles  Academic Article
  • Efforts toward expansion of the genetic alphabet: structure and replication of unnatural base pairs  Academic Article
  • Electron crystallography of proteins in membranes  Academic Article
  • Electron tunneling in protein crystals  Academic Article
  • Electron tunneling in single crystals of Pseudomonas aeruginosa azurins  Academic Article
  • Elemental isomerism: A boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands  Academic Article
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  • Elucidating the mechanism of the asymmetric aza-Michael reaction  Academic Article
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  • Enantioselective ortho-C-H cross-coupling of diarylmethylamines with organoborons  Academic Article
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  • Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme  Academic Article
  • Energetics of quasiequivalence: computational analysis of protein-protein interactions in icosahedral viruses  Academic Article
  • Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo  Academic Article
  • Engineering protein for X-ray crystallography: the murine major histocompatibility complex class II molecule I-A(d)  Academic Article
  • Engineering the polyproline II propensity of a class II major histocompatibility complex ligand peptide  Academic Article
  • Enhanced local symmetry interactions globally stabilize a mutant virus capsid that maintains infectivity and capsid dynamics  Academic Article
  • Enhanced major histocompatibility complex class i binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide  Academic Article
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  • Escherichia coli MutS tetramerization domain structure reveals that stable dimers but not tetramers are essential for DNA mismatch repair in vivo  Academic Article
  • Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants  Academic Article
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  • Evidence for an intermediate conformational state of lacy  Academic Article
  • Evidence for assembly-dependent folding of protein and rna in an icosahedral virus  Academic Article
  • Evolution and mechanism from structures of an adp-ribosylating toxin and nad complex  Academic Article
  • Evolution of amber suppressor tRNAs for efficient bacterial production of proteins containing nonnatural amino acids  Academic Article
  • Evolution of negative cooperativity in glutathione transferase enabled preservation of enzyme function  Academic Article
  • Evolution of shape complementarity and catalytic efficiency from a primordial antibody template  Academic Article
  • Exon 5 encoded domain is not required for the toxic function of mutant sod1 but essential for the dismutase activity: Identification and characterization of two new sod1 mutations associated with familial amyotrophic lateral sclerosis  Academic Article
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  • Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors  Academic Article
  • Exploring icosahedral virus structures with VIPER  Academic Article
  • Exploring the repeat protein universe through computational protein design  Academic Article
  • Expression, purification, crystallization and preliminary x-ray analysis of the olfactomedin domain from the sea urchin cell-adhesion protein amassin  Academic Article
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  • FeMo cofactor of nitrogenase: energetics and local interactions in the protein environment  Academic Article
  • Femtosecond crystallography of membrane proteins in the lipidic cubic phase  Academic Article
  • Fibronectin type III domains engineered to bind CD40L: cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of two complexes  Academic Article
  • Fine tuning a molecular motor: The location of alternative domains in the drosophila myosin head  Academic Article
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  • Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement  Academic Article
  • Flexibility in the ABC transporter MsbA: Alternating access with a twist  Academic Article
  • Flipping of alkylated DNA damage bridges base and nucleotide excision repair  Academic Article
  • Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase  Academic Article
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  • Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing  Academic Article
  • Folate binding site of flavin-dependent thymidylate synthase  Academic Article
  • Foldamers with heterogeneous backbones  Academic Article
  • Folding and particle assembly are disrupted by single-point mutations near the autocatalytic cleavage site of nudaurelia capensis omega virus capsid protein  Academic Article
  • Formation of a chloride-conducting state in the maltose ATP-binding cassette (ABC) transporter  Academic Article
  • Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1  Academic Article
  • Four-step synthesis of the antimalarial cardamom peroxide via an oxygen stitching strategy  Academic Article
  • Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)  Academic Article
  • Fragment-based discovery of JAK-2 inhibitors  Academic Article
  • Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)  Academic Article
  • Fragment-based screen against HIV protease  Academic Article
  • From molecular diversity to catalysis: lessons from the immune system  Academic Article
  • Full-length archaeal rad51 structure and mutants: Mechanisms for rad51 assembly and control by brca2  Academic Article
  • Functional analysis of hairpin ribozyme active site architecture  Academic Article
  • Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein  Academic Article
  • Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase  Academic Article
  • Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima  Academic Article
  • Functional implications of quasi-equivalence in a T=3 icosahedral animal virus established by cryo-electron microscopy and X-ray crystallography  Academic Article
  • Functional mimicry of a protein hormone by a peptide agonist: The epo receptor complex at 2.8 Å  Academic Article
  • Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes  Academic Article
  • Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes  Academic Article
  • Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors  Academic Article
  • Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody  Academic Article
  • G domain dimerization controls dynamin's assembly-stimulated gtpase activity  Academic Article
  • GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function  Academic Article
  • Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors  Academic Article
  • Gating mechanisms of acid-sensing ion channels  Academic Article
  • Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev  Academic Article
  • Generation and structural analysis of reactive empty particles derived from an icosahedral virus  Academic Article
  • Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe  Academic Article
  • Genetically encoded fragment-based discovery of glycopeptide ligands for carbohydrate-binding proteins  Academic Article
  • Genome pool strategy for structural coverage of protein families  Academic Article
  • Genomics, evolution, and crystal structure of a new family of bacterial spore kinases  Academic Article
  • Geometric and electrostatic study of the [4Fe-4S] cluster of adenosine-5'-phosphosulfate reductase from broken symmetry density functional calculations and extended X-ray absorption fine structure spectroscopy  Academic Article
  • Geometric considerations in virus capsid size specificity, auxiliary requirements, and buckling  Academic Article
  • Global structural changes in hepatitis b virus capsids induced by the assembly effector hap1  Academic Article
  • Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain  Academic Article
  • Glutathione transferase: new model for glutathione activation  Academic Article
  • Go hybrid: EM, crystallography, and beyond  Academic Article
  • Gpcr agonist binding revealed by modeling and crystallography  Academic Article
  • Helix bundle quaternary structure from α/β-peptide foldamers  Academic Article
  • Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions  Academic Article
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  • Hepatitis C virus E2 envelope glycoprotein core structure  Academic Article
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  • Heterologous rna encapsidated in pariacoto virus-like particles forms a dodecahedral cage similar to genomic rna in wild-type virions  Academic Article
  • Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity  Academic Article
  • Hexagonal assembly of a restricting trim5 alpha protein  Academic Article
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  • High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor  Academic Article
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  • High-resolution model of the microtubule  Academic Article
  • High-resolution protein complexes from integrating genomic information with molecular simulation  Academic Article
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  • High-resolution solution structure of the retinoid X receptor DNA-binding domain  Academic Article
  • High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin  Academic Article
  • High-resolution structure of a protein spin-label in a solvent-exposed β-sheet and comparison with DEER spectroscopy  Academic Article
  • High-resolution structure of a β-peptide bundle  Academic Article
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  • Lipidic cubic phase technologies for membrane protein structural studies  Academic Article
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  • Production, characterization, and assessment of a stable analog of the response regulator CheY-phosphate from Thermotoga maritima  Academic Article
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  • Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with escherichia coli uracil-DNA glycosylase  Academic Article
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  • Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS  Academic Article
  • Rational HIV immunogen design to target specific germline B cell receptors  Academic Article
  • Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues  Academic Article
  • Rational design of lipid for membrane protein crystallization  Academic Article
  • Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform  Academic Article
  • Rational design of potent human transthyretin amyloid disease inhibitors  Academic Article
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  • Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents  Academic Article
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  • Recognition of microbial glycans by human intelectin-1  Academic Article
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  • Recognition of the ring-opened state of proliferating cell nuclear antigen by replication factor c promotes eukaryotic clamp-loading  Academic Article
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  • Reconstruction of the chemotaxis receptor-kinase assembly  Academic Article
  • Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop  Academic Article
  • Reduction of bicyclo[3.3.1]nonane-2,8-diones with baker's yeast  Academic Article
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  • Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution  Academic Article
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  • Rhombohedral crystals of the human vinculin head domain in complex with a vinculin-binding site of talin  Academic Article
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  • Robotics for automated crystal formation and analysis  Academic Article
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  • Role of tryptophan 161 in catalysis by human manganese superoxide dismutase  Academic Article
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  • Scorpion-toxin mimics of cd4 in complex with human immunodeficiency virus gp120: Crystal structures, molecular mimicry, and neutralization breadth  Academic Article
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  • Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids  Academic Article
  • Selective N1/N4 1,4-Cycloaddition of 1,2,4,5-Tetrazines Enabled by Solvent Hydrogen Bonding  Academic Article
  • Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor  Academic Article
  • Selective recognition and extraction of the uranyl ion  Academic Article
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  • Sequence and structural convergence of broad and potent hiv antibodies that mimic cd4 binding  Academic Article
  • Sequence homology and structural analysis of the clostridial neurotoxins  Academic Article
  • Sequence recognition of DNA by lexitropsins  Academic Article
  • Serial femtosecond crystallography of G protein-coupled receptors  Academic Article
  • Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family  Academic Article
  • Sesquiterpenes from the basidiomycete Omphalotus illudens  Academic Article
  • Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme  Academic Article
  • Shared and unique determinants of the erythropoietin (epo) receptor are important for binding epo and epo mimetic peptide  Academic Article
  • Short total synthesis of (+/-)-sceptrin  Academic Article
  • Short, enantioselective total synthesis of chatancin  Academic Article
  • Shotgun crystallization strategy for structural genomics: An optimized two-tiered crystallization screen against the Thermotoga maritima proteome  Academic Article
  • Side chain conformational averaging in human dihydrofolate reductase  Academic Article
  • Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor  Academic Article
  • Simultaneous refinement of the structure of bpti against NMR data measured in solution and x-ray-diffraction data measured in single-crystals  Academic Article
  • Single particle image reconstruction of the human recombinant kv2.1 channel  Academic Article
  • Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines  Academic Article
  • Site-directed mutagenesis azotobacter-vinelandii ferredoxin-i - cysteine ligation of the 4fe-4s cluster with protein rearrangement is preferred over serine ligation  Academic Article
  • Site-specific protein modification through Cu-I-catalyzed 1,2,3-triazole formation and its implementation in protein microarray fabrication  Academic Article
  • Situs: A package for docking crystal structures into low-resolution maps from electron microscopy  Academic Article
  • Small compounds targeted to subunit interfaces arrest maturation in a nonenveloped, icosahedral animal virus  Academic Article
  • Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept  Academic Article
  • Small molecule modulation of nuclear receptor conformational dynamics: implications for function and drug discovery  Academic Article
  • Small molecule regulation of protein conformation by binding in the flap of HIV protease  Academic Article
  • Small terminase couples viral DNA binding to genome-packaging ATPase activity  Academic Article
  • Small-molecule binding to an artificially created cavity at the active-site of cytochrome-c peroxidase  Academic Article
  • Small-molecule inhibitors of the c-Fes protein-tyrosine kinase  Academic Article
  • Small-molecule/polymer recognition triggers aqueous-phase assembly and encapsulation  Academic Article
  • Smoke-derived karrikin perception by the α/β-hydrolase KAI2 from Arabidopsis  Academic Article
  • Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein  Academic Article
  • Sodium ion binding pocket mutations and adenosine A2A receptor function  Academic Article
  • Software for the high-throughput collection of saxs data using an enhanced blu-ice/dcs control system  Academic Article
  • Solid-state and solution studies of a tetrameric capsule and its guests  Academic Article
  • Soluble guanylate cyclase is activated differently by excess no and by yc-1: Resonance raman spectroscopic evidence  Academic Article
  • Solution structure of an ABC collagen heterotrimer reveals a single-register helix stabilized by electrostatic interactions  Academic Article
  • Solution structure of the N-terminal EGF-like domain from human factor VII  Academic Article
  • Solvent isotope effects on interfacial protein electron transfer in crystals and electrode films  Academic Article
  • Specific recognition of a DNA immunogen by its elicited antibody  Academic Article
  • Spin coupling in Roussin's red and black salts  Academic Article
  • Spin labeling monitors weak host-guest interactions  Academic Article
  • Spirotetrahydro beta-carbolines (spiroindolones): A new class of potent and orally efficacious compounds for the treatment of malaria  Academic Article
  • Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies  Academic Article
  • Status of gpcr modeling and docking as reflected by community-wide gpcr dock 2010 assessment  Academic Article
  • Stereoselective 1,3-insertions of rhodium(II) azavinyl carbenes  Academic Article
  • Stereoselective synthesis and osteogenic activity of subglutinols A and B  Academic Article
  • Steric and conformational features of the aconitase mechanism  Academic Article
  • Steroid receptor coactivator peptidomimetics  Academic Article
  • Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins  Academic Article
  • Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis  Academic Article
  • Streptococcal m1 protein constructs a pathological host fibrinogen network  Academic Article
  • Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase  Academic Article
  • Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling  Academic Article
  • Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1  Academic Article
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  • Structural analysis of arabinose-5-phosphate isomerase from Bacteroides fragilis and functional implications  Academic Article
  • Structural analysis of caspase-1 inhibitors derived from Tethering  Academic Article
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  • Structural analysis of inhibitor binding to human carbonic anhydrase II  Academic Article
  • Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity  Academic Article
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  • Structural and biochemical characterization of the therapeutic anabaena variabilis phenylalanine ammonia lyase  Academic Article
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  • Structural and biophysical characterization of Bacillus thuringiensis insecticidal proteins Cry34Ab1 and Cry35Ab1  Academic Article
  • Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum  Academic Article
  • Structural and chemical requirements for histidine phosphorylation by the chemotaxis kinase CheA  Academic Article
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  • Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases  Academic Article
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  • Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19  Academic Article
  • Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe  Academic Article
  • Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding  Academic Article
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  • Structural basis for a disfavored elimination reaction in catalytic antibody 1D4  Academic Article
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  • Structural basis for amplifying vinculin activation by talin  Academic Article
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  • Structural basis for bifunctional peptide recognition at human delta-opioid receptor  Academic Article
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  • Structural basis for the activation of IKK1/α  Academic Article
  • Structural basis for the binding of an anti-cytochrome c antibody to its antigen: Crystal structures of FabE8 cytochrome c complex to 1.8 Å resolution and FabE8 to 2.26 Å resolution  Academic Article
  • Structural basis for the coevolution of a viral RNA-protein complex  Academic Article
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  • Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling  Academic Article
  • Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2  Academic Article
  • Structural basis of Rho GTPase-mediated activation of the formin rndia1  Academic Article
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  • Structural basis of alpha-fucosidase inhibition by iminocyclitols with K(i) values in the micro- to picomolar range  Academic Article
  • Structural basis of autoregulation of phenylalanine hydroxylase  Academic Article
  • Structural basis of cell surface receptor recognition by botulinum neurotoxin B  Academic Article
  • Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform fimd  Academic Article
  • Structural basis of drug binding to cyp46a1, an enzyme that controls cholesterol turnover in the brain  Academic Article
  • Structural basis of guanine nucleotide exchange mediated by the t-cell essential vav1  Academic Article
  • Structural basis of immune evasion at the site of cd4 attachment on hiv-1 gp120  Academic Article
  • Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion  Academic Article
  • Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R  Academic Article
  • Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters  Academic Article
  • Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen  Academic Article
  • Structural basis of preexisting immunity to the 2009 h1n1 pandemic influenza virus  Academic Article
  • Structural basis of single-nucleotide polymorphisms in cytochrome P450 2C9  Academic Article
  • Structural basis of small-molecule aggregate induced inhibition of a protein protein interaction  Academic Article
  • Structural basis of steroid hormone perception by the receptor kinase bri1  Academic Article
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  • Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant  Academic Article
  • Structural basis of tlr5-flagellin recognition and signaling  Academic Article
  • Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120  Academic Article
  • Structural basis underlying the binding preference of human galectins-1,-3 and-7 for Galβ1-3/4GlcNAc  Academic Article
  • Structural biochemistry of a type 2 rnase h: Rna primer recognition and removal during DNA replication  Academic Article
  • Structural biology of viruses by the combination of electron cryomicroscopy and x-ray crystallography  Academic Article
  • Structural changes that occur upon photolysis of the fe(ii)(a3)-co complex in the cytochrome ba(3)-oxidase of thermus thermophilus: A combined x-ray crystallographic and infrared spectral study demonstrates co binding to cu-b  Academic Article
  • Structural characterization and epitope mapping of the glutamic acid/alanine-rich protein from Trypanosoma congolense: defining assembly on the parasite cell surface  Academic Article
  • Structural characterization of S100A15 reveals a novel zinc coordination site among S100 proteins and altered surface chemistry with functional implications for receptor binding  Academic Article
  • Structural characterization of a human Fc fragment engineered for lack of effector functions  Academic Article
  • Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism  Academic Article
  • Structural characterization of an early fusion intermediate of influenza virus hemagglutinin  Academic Article
  • Structural characterization of anti-CCL5 activity of the tick salivary protein evasin-4  Academic Article
  • Structural characterization of enterobactin hydrolase IroE  Academic Article
  • Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19  Academic Article
  • Structural characterization of the 1918 influenza virus h1n1 neuraminidase  Academic Article
  • Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1  Academic Article
  • Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the clostridium botulinum serotype a neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility  Academic Article
  • Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS  Academic Article
  • Structural commonalities among integral membrane enzymes  Academic Article
  • Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions  Academic Article
  • Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: Similar fold, different stability and reaction rates  Academic Article
  • Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex  Academic Article
  • Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers  Academic Article
  • Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members  Academic Article
  • Structural dynamics of alpha-actinin-vinculin interactions  Academic Article
  • Structural evaluation of potent NKT cell agonists: Implications for design of novel stimulatory ligands  Academic Article
  • Structural evidence for an enolate intermediate in gfp fluorophore biosynthesis  Academic Article
  • Structural evidence for substrate strain in antibody catalysis  Academic Article
  • Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides  Academic Article
  • Structural features for functional selectivity at serotonin receptors  Academic Article
  • Structural insight into pH-induced conformational changes within the native human transthyretin tetramer  Academic Article
  • Structural insight into the low affinity between Thermotoga maritima CheA and CheB compared to their Escherichia coli/Salmonella typhimurium counterparts  Academic Article
  • Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein  Academic Article
  • Structural insights into charge pair interactions in triple helical collagen-like proteins  Academic Article
  • Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B  Academic Article
  • Structural insights into inhibition of bacillus anthracis sporulation by a novel class of non-heme globin sensor domains  Academic Article
  • Structural insights into inhibition of lipid I production in bacterial cell wall synthesis  Academic Article
  • Structural insights into neonatal Fc receptor-based recycling mechanisms  Academic Article
  • Structural insights into the avian aicar transformylase mechanism  Academic Article
  • Structural insights into the catalytic mechanism of bacterial guanosine-diphospho-D-mannose pyrophosphorylase and its regulation by divalent ions  Academic Article
  • Structural insights into the design of nonpeptidic isothiazolidinone-containing inhibitors of protein-tyrosine phosphatase 1B  Academic Article
  • Structural insights into the evolution of an antibody combining site  Academic Article
  • Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor  Academic Article
  • Structural insights into the interaction of IL-33 with its receptors  Academic Article
  • Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody  Academic Article
  • Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3  Academic Article
  • Structural insights into the recognition of phosphopeptide by the FHA domain of kanadaptin  Academic Article
  • Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins  Academic Article
  • Structural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103  Academic Article
  • Structural interconversions modulate activity of escherichia coli ribonucleotide reductase  Academic Article
  • Structural invariance of constitutively active and inactive mutants of acanthamoeba myosin ic bound to f-actin in the rigor and adp-bound states  Academic Article
  • Structural mechanism for signal transduction in RXR nuclear receptor heterodimers  Academic Article
  • Structural mechanism of GAF-regulated sigma(54) activators from Aquifex aeolicus  Academic Article
  • Structural mechanism of abscisic acid binding and signaling by dimeric PYR1  Academic Article
  • Structural mechanisms of allostery and autoinhibition in JNK family kinases  Academic Article
  • Structural origins of efficient proton abstraction from carbon by a catalytic antibody  Academic Article
  • Structural plasticity and the evolution of antibody affinity and specificity  Academic Article
  • Structural plasticity in the oestrogen receptor ligand-binding domain  Academic Article
  • Structural plasticity of an aminoacyl-tRNA synthetase active site  Academic Article
  • Structural rearrangement of ebola virus VP40 begets multiple functions in the virus life cycle  Academic Article
  • Structural revision and total synthesis of caraphenol B and C  Academic Article
  • Structural studies of FIV and HIV-1 proteases complexed with all efficient inhibitor of FIV protease  Academic Article
  • Structural studies of human HIV-1 V3 antibodies  Academic Article
  • Structural studies on phenylalanine hydroxylase and implications toward understanding and treating phenylketonuria  Academic Article
  • Structural switch of lysyl-tRNA synthetase between translation and transcription  Academic Article
  • Structural tuning of the fluorescent protein iLOV for improved photostability  Academic Article
  • Structural variations in species B adenovirus fibers impact CD46 association  Academic Article
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  • Structural-based analysis of dihydrofolate reductase evolution  Academic Article
  • Structure Based Design of CYP51 Inhibitors  Academic Article
  • Structure activity relationships of human galactokinase inhibitors  Academic Article
  • Structure analysis of peptide deformylases from Streptococcus pneumoniae, Staphylococcus aureus, Thermotoga maritima and Pseudomonas aeruginosa: Snapshots of the oxygen sensitivity of peptide deformylase  Academic Article
  • Structure and activity of a thermostable thymine-DNA glycosylase: Evidence for base twisting to remove mismatched normal DNA bases  Academic Article
  • Structure and activity of the flagellar rotor protein FliY: a member of the CheC phosphatase family  Academic Article
  • Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly  Academic Article
  • Structure and function of a genetically engineered mimic of a nonenveloped virus entry intermediate  Academic Article
  • Structure and function of a membrane-bound murine MHC class I molecule  Academic Article
  • Structure and function of a novel LD-carboxypeptidase A involved in peptidoglycan recycling  Academic Article
  • Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor  Academic Article
  • Structure and function of an unusual family of protein phosphatases: the bacterial chemotaxis proteins CheC and CheX  Academic Article
  • Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1  Academic Article
  • Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme  Academic Article
  • Structure and function of the double-strand break repair machinery  Academic Article
  • Structure and function of the first full-length murein peptide ligase (mpl) cell wall recycling protein  Academic Article
  • Structure and function of the multifunctional DNA-repair enzyme exonuclease-iii  Academic Article
  • Structure and functional characterization of a bile acid 7α dehydratase BaiE in secondary bile acid synthesis  Academic Article
  • Structure and functional characterization of the rna-binding element of the nlrx1 innate immune modulator  Academic Article
  • Structure and functional role of dynein's microtubule-binding domain  Academic Article
  • Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues  Academic Article
  • Structure and internal dynamics of the bovine pancreatic trypsin-inhibitor in aqueous-solution from long-time molecular-dynamics simulations  Academic Article
  • Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634  Academic Article
  • Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors  Academic Article
  • Structure and mechanism of Helicobacter pylori fucosyltransferase: a basis for lipopolysaccharide variation and inhibitor design  Academic Article
  • Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity  Academic Article
  • Structure and mechanism of the ruvb holliday junction branch migration motor  Academic Article
  • Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2f5 in complex with its gp41 epitope  Academic Article
  • Structure and mutational analysis of Rab GDP-dissociation inhibitor  Academic Article
  • Structure and reactivity of an asymmetric complex between hslv and i-domain deleted hslu, a prokaryotic homolog of the eukaryotic proteasome  Academic Article
  • Structure and receptor binding of the hemagglutinin from a human H6N1 influenza virus  Academic Article
  • Structure and receptor binding specificity of hemagglutinin H13 from avian influenza A virus H13N6  Academic Article
  • Structure and receptor specificity of the hemagglutinin from an h5n1 influenza virus  Academic Article
  • Structure and regulatory mechanism of Aquifex aeolicus NtrC4: variability and evolution in bacterial transcriptional regulation  Academic Article
  • Structure and thermodynamic characterization of the ephb4/ephrin-b2 antagonist peptide complex reveals the determinants for receptor specificity  Academic Article
  • Structure at 0.85 Å resolution of an early protein photocycle intermediate  Academic Article
  • Structure determination of an anti-hiv-1 fab 447-52d-peptide complex from an epitaxially twinned data set  Academic Article
  • Structure determination of naudaurelia capensis omega virus  Academic Article
  • Structure determination of the 1918 h1n1 neuraminidase from a crystal with lattice-translocation defects  Academic Article
  • Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation  Academic Article
  • Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules  Academic Article
  • Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 A resolution: The first structural representative of a new protein family that may play a role in carbohydrate metabolism  Academic Article
  • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9  Academic Article
  • Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism  Academic Article
  • Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding  Academic Article
  • Structure of REV-ERB beta ligand-binding domain bound to a porphyrin antagonist  Academic Article
  • Structure of SARS coronavirus spike receptor-binding domain complexed with receptor  Academic Article
  • Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase  Academic Article
  • Structure of Thermotoga maritima TM0439: Implications for the mechanism of bacterial GntR transcription regulators with Zn(2+)-binding FCD domains  Academic Article
  • Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion  Academic Article
  • Structure of a cation-bound multidrug and toxic compound extrusion transporter  Academic Article
  • Structure of a central component of the yeast kinetochore: The Spc24p/Spc25p globular domain  Academic Article
  • Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator  Academic Article
  • Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 hemagglutinin  Academic Article
  • Structure of a classical broadly neutralizing stem antibody in complex with a pandemic h2 hemagglutinin  Academic Article
  • Structure of a copper-mediated base pair in DNA  Academic Article
  • Structure of a designed protein cage that self-assembles into a highly porous cube  Academic Article
  • Structure of a dicationic monoimidazole lexitropsin bound to DNA  Academic Article
  • Structure of a kinesin microtubule depolymerization machine  Academic Article
  • Structure of a light-activated LOV protein dimer that regulates transcription  Academic Article
  • Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron  Academic Article
  • Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site  Academic Article
  • Structure of a nitric oxide synthase heme protein from Bacillus subtilis  Academic Article
  • Structure of a novel winged-helix like domain from human NFRKB protein  Academic Article
  • Structure of a protein photocycle intermediate by millisecond time-resolved crystallography  Academic Article
  • Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15  Academic Article
  • Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes  Academic Article
  • Structure of a thioredoxin-like 2fe-2s ferredoxin from aquifex aeolicus  Academic Article
  • Structure of a trimeric nucleoporin complex reveals alternate oligomerization states  Academic Article
  • Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster  Academic Article
  • Structure of a v3-containing hiv-1 gp120 core  Academic Article
  • Structure of aart, a designed six-finger zinc finger peptide, bound to DNA  Academic Article
  • Structure of an MmyB-like regulator from C-aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes  Academic Article
  • Structure of an agonist-bound human A₂A adenosine receptor  Academic Article
  • Structure of an archaeal virus capsid protein reveals a common ancestry to eukaryotic and bacterial viruses  Academic Article
  • Structure of an enclosed dimer formed by the Drosophila period protein  Academic Article
  • Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5 A resolution  Academic Article
  • Structure of an essential type iv pilus biogenesis protein provides insights into pilus and type ii secretion systems  Academic Article
  • Structure of an hiv gp120 envelope glycoprotein in complex with the cd4 receptor and a neutralizing human antibody  Academic Article
  • Structure of antibody f425-b4e8 in complex with a v3 peptide reveals a new binding mode for hiv-1 neutralization  Academic Article
  • Structure of avian aicar transformylase with a multisubstrate adduct inhibitor β-DADF identifies the folate binding site  Academic Article
  • Structure of azotobacter vinelandii 7fe ferredoxin at 1.35 Å resolution and determination of the fe-s bonds with 0.01 Å accuracy  Academic Article
  • Structure of botulinurn neurotoxin type d light chain at 1.65 Å resolution: Repercussions for vamp-2 substrate specificity  Academic Article
  • Structure of cardiac gap junction intercellular channels  Academic Article
  • Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway  Academic Article
  • Structure of full-length Drosophila cryptochrome  Academic Article
  • Structure of full-length hiv-1ca: A model for the mature capsid lattice  Academic Article
  • Structure of hepatitis C virus envelope glycoprotein E1 antigenic site 314-324 in complex with antibody IGH526  Academic Article
  • Structure of hiv-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility  Academic Article
  • Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding  Academic Article
  • Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding  Academic Article
  • Structure of mammalian poly(adp- ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element  Academic Article
  • Structure of microsomal cytochrome p4502b4 complexed with the antifungal drug bifonazole - insight into p450 conformational plasticity and membrane interaction  Academic Article
  • Structure of native and expanded sobemoviruses by electron cryo-microscopy and image reconstruction  Academic Article
  • Structure of nitric oxide synthase oxygenase dimer with pterin and substrate  Academic Article
  • Structure of phaseolin at 2.2 Å resolution - implications for a common vicilin/legumin structure and the genetic-engineering of seed storage proteins  Academic Article
  • Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase  Academic Article
  • Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria  Academic Article
  • Structure of the Angiotensin receptor revealed by serial femtosecond crystallography  Academic Article
  • Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone  Academic Article
  • Structure of the DNA repair enzyme endonuclease iv and its DNA complex: Double-nucleotide flipping at abasic sites and three-metal-ion catalysis  Academic Article
  • Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression  Academic Article
  • Structure of the Reston ebolavirus VP30 C-terminal domain  Academic Article
  • Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain  Academic Article
  • Structure of the apo anti-influenza CH65 Fab  Academic Article
  • Structure of the bifunctional acyltransferase/decarboxylase lnmk from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold  Academic Article
  • Structure of the ebola virus glycoprotein bound to an antibody from a human survivor  Academic Article
  • Structure of the fiber-forming protein pilin at 2.6 Å resolution  Academic Article
  • Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation  Academic Article
  • Structure of the first representative of pfam family pf09410 (duf2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism  Academic Article
  • Structure of the frequency-interacting RNA helicase: a protein interaction hub for the circadian clock  Academic Article
  • Structure of the glucagon receptor in complex with a glucagon analogue  Academic Article
  • Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza c virus  Academic Article
  • Structure of the human ATG12 similar to ATG5 conjugate required for LC3 lipidation in autophagy  Academic Article
  • Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs  Academic Article
  • Structure of the human P2Y(12) receptor in complex with an antithrombotic drug  Academic Article
  • Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist  Academic Article
  • Structure of the human glucagon class B G-protein-coupled receptor  Academic Article
  • Structure of the human histamine h(1) receptor complex with doxepin  Academic Article
  • Structure of the human lung cytochrome p450 2a13  Academic Article
  • Structure of the human smoothened receptor bound to an antitumour agent  Academic Article
  • Structure of the human κ-opioid receptor in complex with JDTic  Academic Article
  • Structure of the multidrug transporter emrd from escherichia coli  Academic Article
  • Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity  Academic Article
  • Structure of the n terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members  Academic Article
  • Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic  Academic Article
  • Structure of the pilus assembly protein TadZ from eubacterium rectale: Implications for polar localization  Academic Article
  • Structure of the uncleaved human h1 hemagglutinin from the extinct 1918 influenza virus  Academic Article
  • Structure of the wilms tumor suppressor protein zinc finger domain bound to DNA  Academic Article
  • Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase  Academic Article
  • Structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases  Academic Article
  • Structure of yeast RNA polymerase II in solution: Implications for enzyme regulation and interaction with promoter DNA  Academic Article
  • Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of Mycobacteria  Academic Article
  • Structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 h2n2 pandemic  Academic Article
  • Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors  Academic Article
  • Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-jun N-terminal kinase 3 (JNK3) over p38  Academic Article
  • Structure-based analysis of Bacilli and plasmid dihydrofolate reductase evolution  Academic Article
  • Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics  Academic Article
  • Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors  Academic Article
  • Structure-based design and synthesis of potent and selective matrix metalloproteinase 13 inhibitors  Academic Article
  • Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site  Academic Article
  • Structure-based design of a protein immunogen that displays an hiv-1 gp41 neutralizing epitope  Academic Article
  • Structure-based design of peptide presentation on a viral surface: The crystal structure of a plant/animal virus chimera at 2.8 Å resolution  Academic Article
  • Structure-based design of thienobenzoxepin inhibitors of PI3-kinase  Academic Article
  • Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors  Academic Article
  • Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2  Academic Article
  • Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells  Academic Article
  • Structure-based discovery of cellular-active allosteric inhibitors of FAK  Academic Article
  • Structure-based engineering of internal cavities in coiled-coil peptides  Academic Article
  • Structure-based mutagenesis approaches toward expanding the substrate specificity of d-2-deoxyribose-5-phosphate aldolase  Academic Article
  • Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin  Academic Article
  • Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase  Academic Article
  • Structure-based rationale for the rescue of systemic movement of brome mosaic virus by spontaneous second-site mutations in the coat protein gene  Academic Article
  • Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine  Academic Article
  • Structure-factor extrapolation using the scalar approximation: theory, applications and limitations  Academic Article
  • Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1  Academic Article
  • Structure-function-folding relationship in a WW domain  Academic Article
  • Structure-guided expansion of kinase fragment libraries driven by support vector machine models  Academic Article
  • Structure-guided functional characterization of DUF1460 reveals a highly specific NlpC/P60 amidase family  Academic Article
  • Structure-guided inhibitor design for human FAAH by interspecies active site conversion  Academic Article
  • Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains  Academic Article
  • Structure-specific tRNA-binding protein from the extreme thermophile Aquifex aeolicus  Academic Article
  • Structure/function studies on a S-adenosyl-(L)-methionine-dependent uroporphyrinogen III C methyltransferase (SUMT), a key regulatory enzyme of tetrapyrrole biosynthesis  Academic Article
  • Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection  Academic Article
  • Structures of a bifunctional cell wall hydrolase CwlT containing a novel bacterial lysozyme and an NlpC/P60 DL-endopeptidase  Academic Article
  • Structures of clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility  Academic Article
  • Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel  Academic Article
  • Structures of cytochrome p450 2b6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: Insight into inhibitor binding and rearrangement of active site side chains  Academic Article
  • Structures of endonuclease v with DNA reveal initiation of deaminated adenine repair  Academic Article
  • Structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms  Academic Article
  • Structures of hiv-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates  Academic Article
  • Structures of picorna-like plant viruses: Implications and applications  Academic Article
  • Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition  Academic Article
  • Structures of ruthenium-modified Pseudomonas aeruginosa azurin and [Ru(2,2 '-bipyridine)(2)(imidazole)(2)]SO4.10H(2)O  Academic Article
  • Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457  Academic Article
  • Structures of the N-omega-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins  Academic Article
  • Structures of the ccr5 n terminus and of a tyrosine-sulfated antibody with hiv-1 gp120 and cd4  Academic Article
  • Structures of the cxcr4 chemokine gpcr with small-molecule and cyclic peptide antagonists  Academic Article
  • Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism  Academic Article
  • Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction  Academic Article
  • Structures of the native and swollen forms of cowpea chlorotic mottle virus determined by x-ray crystallography and cryoelectron microscopy  Academic Article
  • Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: Heme activation via reduction-gated exogenous ligand exchange  Academic Article
  • Structures of thermolabile mutants of human glutathione transferase P1-1  Academic Article
  • Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved alpha plus beta core domain and an auxiliary C-terminal treble-clef zinc finger  Academic Article
  • Structures of tryptophanyl-tRNA synthetase II from Deinococcus radiodurans bound to ATP and tryptophan. Insight into subunit cooperativity and domain motions linked to catalysis  Academic Article
  • Structures of virus and virus-like particles  Academic Article
  • Studies on the synthesis of bafilomycin A(1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C25) segment  Academic Article
  • Studies on the synthesis of landomycin A. Synthesis of the originally assigned structure of the aglycone, landomycinone, and revision of structure  Academic Article
  • Substituting c-jun n-terminal kinase-3 (jnk3) atp-binding site amino acid residues with their p38 counterparts affects binding of jnk- and p38-selective inhibitors  Academic Article
  • Substitution of ribonucleotides in the T7 RNA polymerase promoter element  Academic Article
  • Substrate profiling and high resolution co-complex crystal structure of a secreted C11 protease conserved across commensal bacteria  Academic Article
  • Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal  Academic Article
  • Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus  Academic Article
  • Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ  Academic Article
  • Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase  Academic Article
  • Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes  Academic Article
  • Sulfite reductase structure at 1.6 Å - evolution and catalysis for reduction of inorganic anions  Academic Article
  • Superoxide dismutase from the eukaryotic thermophile alvinella pompejana: Structures, stability, mechanism, and insights into amyotrophic lateral sclerosis  Academic Article
  • Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120  Academic Article
  • Supramolecular organization of the repetitive backbone unit of the Streptococcus pneumoniae pilus  Academic Article
  • Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase  Academic Article
  • Symmetrical stabilization of bound Ca2+ ions in a cooperative pair of EF-hands through hydrogen bonding of coordinating water molecules in calbindin D-9k  Academic Article
  • Synergy of NMR, computation, and x-ray crystallography for structural biology  Academic Article
  • Synthesis and SAR of p38 alpha MAP kinase inhibitors based on heterobicyclic scaffolds  Academic Article
  • Synthesis and X-ray analysis of an unprecedented and stable 2-aza-4,4-spirocyclopropacyclohexadienone  Academic Article
  • Synthesis and activity of new aryl- and heteroaryl- substituted pyrazole inhibitors of the transforming growth factor-βtype I receptor kinase domain  Academic Article
  • Synthesis and activity of ruthenium alkylidene complexes coordinated with phosphine and N-heterocyclic carbene ligands  Academic Article
  • Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor  Academic Article
  • Synthesis and characterization of a cyclobutane duocarmycin derivative incorporating the 1,2,10,11-tetrahydro-9H-cyclobuta[c]benzo[e]indol-4-one (CbBI) alkylation subunit  Academic Article
  • Synthesis and characterization of all four diastereomers of 3,4-dichloro-2-pentanol, motifs relevant to the chlorosulfolipids  Academic Article
  • Synthesis and characterization of cerium and yttrium alkoxide complexes supported by ferrocene-based chelating ligands  Academic Article
  • Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization  Academic Article
  • Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase  Academic Article
  • Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis  Academic Article
  • Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives  Academic Article
  • Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins  Academic Article
  • Synthesis and evaluation of duocarmycin and CC-1065 analogues incorporating the 1,2,9,9a-tetrahydrocyclopropa c benz e -3-azaindol-4-one (CBA) alkylation subunit  Academic Article
  • Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3  Academic Article
  • Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase  Academic Article
  • Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the x-ray structure determination of 9-o-acetylsialic acid esterase from influenza c virus  Academic Article
  • Synthesis and sar of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors  Academic Article
  • Synthesis and self-assembly of NCN-pincer Pd-complex-bound norvalines  Academic Article
  • Synthesis of 1,2- and 1,3-dicarboxylic acids via Pd(II)-catalyzed carboxylation of aryl and vinyl C-H bonds  Academic Article
  • Synthesis of 2-substituted polyhydroxytetrahydropyrimidines (n-hydroxy cyclic guanidino-sugars): Transition state mimics of enzymatic glycosidic cleavage  Academic Article
  • Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid  Academic Article
  • Synthesis of functionalized maoecrystal v core structures  Academic Article
  • Synthesis of fused indazole ring systems and application to nigeglanine hydrobromide  Academic Article
  • Synthesis of substituted dihydrobenzofurans via tandem S(N)Ar/5-exo-trig cyclization  Academic Article
  • Synthesis of the mycolactone core by ring-closing metathesis  Academic Article
  • Synthesis of the tetracyclic core of exiguaquinol  Academic Article
  • Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine  Academic Article
  • Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors  Academic Article
  • Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one alkylation subunit  Academic Article
  • Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors  Academic Article
  • Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors  Academic Article
  • Synthesis-guided structure revision of the sarcodonin, sarcoviolin, and hydnellin natural product family  Academic Article
  • Synthetic inhibitors of cytochrome p-450 2a6: Inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization  Academic Article
  • Synthetic studies on thiostrepton: Construction of thiostrepton analogues with the thiazoline-containing macrocycle  Academic Article
  • Synthetic symmetrization in the crystallization and structure determination of CelA from Thermotoga maritima  Academic Article
  • T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements  Academic Article
  • T-cell receptor structure and tcr complexes  Academic Article
  • TagDock: an efficient rigid body docking algorithm for oligomeric protein complex model construction and experiment planning  Academic Article
  • Tangled up in knots: structures of inactivated forms of E. Coli class Ia ribonucleotide reductase  Academic Article
  • Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis  Academic Article
  • Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors  Academic Article
  • Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes  Academic Article
  • Targeting mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2, MK2): medicinal chemistry efforts to lead small molecule inhibitors to clinical trials  Academic Article
  • Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening  Academic Article
  • Tata element recognition by the tata box-binding protein has been conserved throughout evolution  Academic Article
  • Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein  Academic Article
  • Tetrameric architecture of the circadian clock protein KaiB - a novel interface for intermolecular interactions and its impact on the circadian rhythm  Academic Article
  • The 0.78 Å structure of a serine protease: Bacillus lentus subtilisin  Academic Article
  • The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site  Academic Article
  • The 150-loop restricts the host specificity of human H10N8 influenza virus  Academic Article
  • The 2.3 Å structure of porcine circovirus 2  Academic Article
  • The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist  Academic Article
  • The 2.8 Å structure of a T=4 animal virus and its implications for membrane translocation of RNA  Academic Article
  • The 3.2 A resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays  Academic Article
  • The C-Ala domain brings together editing and aminoacylation functions on one tRNA  Academic Article
  • The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain  Academic Article
  • The EF-hand domain: a globally cooperative structural unit  Academic Article
  • The GPCR Network: a large-scale collaboration to determine human GPCR structure and function  Academic Article
  • The Mossbauer parameters of the proximal cluster of membrane-bound hydrogenase revisited: a density functional theory study  Academic Article
  • The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes  Academic Article
  • The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit  Academic Article
  • The R-factor gap in macromolecular crystallography: an untapped potential for insights on accurate structures  Academic Article
  • The X-ray crystal structure of the human mono-oxygenase cytochrome P450 3A5-ritonavir complex reveals active site differences between P450s 3A4 and 3A5  Academic Article
  • The atomic resolution structure of bucandin, a novel toxin isolated from the malayan krait, determined by direct methods  Academic Article
  • The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50  Academic Article
  • The c-terminal domain of yeast pcna is required for physical and functional interactions with cdc9 DNA ligase  Academic Article
  • The case of the missing ring: Radical cleavage of a carbon-carbon bond and implications for gfp chromophore biosynthesis  Academic Article
  • The cd1 family of lipid antigen-presenting molecules  Academic Article
  • The challenge of protein structure determination - lessons from structural genomics  Academic Article
  • The closing mechanism of DNA polymerase I at atomic resolution  Academic Article
  • The coactivator lxxll nuclear receptor recognition motif  Academic Article
  • The conserved N-capping box in the hydrophobic core of glutathione S-transferase P1-1 is essential for refolding - Identification of a buried and conserved hydrogen bond important for protein stability  Academic Article
  • The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I  Academic Article
  • The crystal structure of NADPH: ferredoxin reductase from Azotobacter vinelandii  Academic Article
  • The crystal structure of a fusagenic sperm protein reveals extreme surface properties  Academic Article
  • The crystal structure of a novel bacterial adenylyltransferase reveals half of sites reactivity  Academic Article
  • The crystal structure of avian cd1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian cd1  Academic Article
  • The crystal structure of cricket paralysis virus: The first view of a new virus family  Academic Article
  • The crystal structure of human Argonaute2  Academic Article
  • The crystal structure of the Helicobacter pylori LlaJI.R1 N-terminal domain provides a model for site-specific DNA binding  Academic Article
  • The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function  Academic Article
  • The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase  Academic Article
  • The crystal structure of the human DNA repair endonuclease hap1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites  Academic Article
  • The crystal structure of yych involved in the regulation of the essential yycfg two-component system in bacillus subtilis reveals a novel tertiary structure  Academic Article
  • The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity  Academic Article
  • The crystal structures of chloramphenicol phosphotransferase reveal a novel inactivation mechanism  Academic Article
  • The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism  Academic Article
  • The crystal-structure of C-C-A-T-T-A-A-T-G-G - implications for bending of B-DNA at T-A steps  Academic Article
  • The crystal-structure of lysin, a fertilization protein  Academic Article
  • The cytochrome ba(3) oxygen reductase from thermus thermophilus uses a single input channel for proton delivery to the active site and for proton pumping  Academic Article
  • The d90a mutation results in a polymorphism of cu,zn superoxide-dismutase that is prevalent in northern sweden and finland  Academic Article
  • The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase  Academic Article
  • The design and synthesis of novel alpha-ketoamide-based p38 map kinase inhibitors  Academic Article
  • The development of n-alpha-(2-carboxyl)benzoyl-n(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-f-amidine) and n-alpha-(2-carboxyl)benzoyl-n(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-cl-amidine) as second generation protein arginine deiminase (pad) inhibitors  Academic Article
  • The diabetogenic mouse MHC class II molecule I-A(g7) is endowed with a switch that modulates TCR affinity  Academic Article
  • The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines  Academic Article
  • The ebola virus interferon antagonist vp24 directly binds stat1 and has a novel, pyramidal fold  Academic Article
  • The ebolavirus VP24 interferon antagonist: know your enemy  Academic Article
  • The evolution of cefotaximase activity in the TEM β-lactamase  Academic Article
  • The first crystal structure of a macromolecular assembly under high pressure: Cpmv at 330 mpa  Academic Article
  • The first method for protection-deprotection of the indole 2,3-pi bond  Academic Article
  • The genesis of high-throughput structure-based drug discovery using protein crystallography  Academic Article
  • The high resolution crystal structure of green abalone sperm lysin: Implications for species-specific binding of the egg receptor  Academic Article
  • The immunological evolution of catalysis  Academic Article
  • The interplay between binding energy and catalysis in the evolution of a catalytic antibody  Academic Article
  • The intricate structural chemistry of base excision repair machinery: Implications for DNA damage recognition, removal, and repair  Academic Article
  • The mechanism of aconitase: 1.8 Å resolution crystal structure of the s642a : Citrate complex  Academic Article
  • The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex  Academic Article
  • The mechanism of high-pressure-induced ordering in a macromolecular crystal  Academic Article
  • The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin  Academic Article
  • The metavinculin tail domain directs constitutive interactions with raver1 and vinculin RNA  Academic Article
  • The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins  Academic Article
  • The molecular basis of allostery in a facilitated dissociation process  Academic Article
  • The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K  Academic Article
  • The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor  Academic Article
  • The native GCN4 leucine-zipper domain does not uniquely specify a dimeric oligomerization state  Academic Article
  • The nuclear-magnetic-resonance solution structure of the mixed disulfide between escherichia-coli glutaredoxin(c14s) and glutathione  Academic Article
  • The origin of enantioselectivity in aldolase antibodies: crystal structure, site-directed mutagenesis, and computational analysis  Academic Article
  • The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme  Academic Article
  • The prohead-i structure of bacteriophage hk97: Implications for scaffold-mediated control of particle assembly and maturation  Academic Article
  • The properties of Msh2-Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair  Academic Article
  • The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together  Academic Article
  • The rad50 signature motif: Essential to atp binding and biological function  Academic Article
  • The rad50 zinc-hook is a structure joining mre11 complexes in DNA recombination and repair  Academic Article
  • The reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complex  Academic Article
  • The refined crystal structure of cowpea mosaic virus at 2.8 Å resolution  Academic Article
  • The refined structure of nudaurelia capensis omega virus reveals control elements for a t=4 capsid maturation  Academic Article
  • The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin  Academic Article
  • The second decade - into the third millennium  Academic Article
  • The selective tRNA aminoacylation mechanism based on a single G.U pair  Academic Article
  • The self-inhibited structure of full-length PCSK9 at 1.9 Å reveals structural homology with resistin within the C-terminal domain  Academic Article
  • The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination  Academic Article
  • The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1  Academic Article
  • The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae  Academic Article
  • The structural basis of protein acetylation by the p300/CBP transcriptional coactivator  Academic Article
  • The structural basis of recognition and removal of cellular mrna 7-methyl g 'caps' by a viral capsid protein: A unique viral response to host defense  Academic Article
  • The structure of Aquifex aeolicus ribosomal protein S8 reveals a unique subdomain that contributes to an extremely tight association with 16S rRNA  Academic Article
  • The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function  Academic Article
  • The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes  Academic Article
  • The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 A resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator  Academic Article
  • The structure of KPN03535 (gi vertical bar 152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold  Academic Article
  • The structure of Mlc titration factor a (MtfA/YeeI) reveals a prototypical zinc metallopeptidase related to anthrax lethal factor  Academic Article
  • The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role  Academic Article
  • The structure of YqeH. An AtNOS1/AtNOA1 ortholog that couples GTP hydrolysis to molecular recognition  Academic Article
  • The structure of a soluble chemoreceptor suggests a mechanism for propagating conformational signals  Academic Article
  • The structure of an infectious P22 virion shows the signal for headful DNA packaging  Academic Article
  • The structure of apo human glutamate dehydrogenase details subunit communication and allostery  Academic Article
  • The structure of cucumber mosaic virus: Cryoelectron microscopy, x-ray crystallography, and sequence analysis  Academic Article
  • The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen  Academic Article
  • The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05 Å resolution  Academic Article
  • The structure of jnk3 in complex with small molecule inhibitors: Structural basis for potency and selectivity  Academic Article
  • The structure of l-tyrosine 2,3-aminomutase from the c-1027 enediyne antitumor antibiotic biosynthetic pathway  Academic Article
  • The structure of microsomal cytochrome P450 2C5: a steroid and drug metabolizing enzyme  Academic Article
  • The structure of mitogen-activated protein kinase p38 at 2.1 Å resolution  Academic Article
  • The structure of nitric oxide synthase oxygenase domain and inhibitor complexes  Academic Article
  • The structure of pariacoto virus reveals a dodecahedral cage of duplex rna  Academic Article
  • The structure of the crispr-associated protein csa3 provides insight into the regulation of the crispr/cas system  Academic Article
  • The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism  Academic Article
  • The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation  Academic Article
  • The structure of the map2k mek6 reveals an autoinhibitory dimer  Academic Article
  • The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex  Academic Article
  • The structure of the nuclear pore complex  Academic Article
  • The structure of the yeast nadh dehydrogenase (ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates  Academic Article
  • The structure of tobacco ringspot virus: A link in the evolution of icosahedral capsids in the picornavirus superfamily  Academic Article
  • The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux  Academic Article
  • The three-dimensional arcitecture of the EJC core  Academic Article
  • The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli  Academic Article
  • The total synthesis of coleophomones B, C, and D  Academic Article
  • The true structures of the vannusals, part 1: Initial forays into suspected structures and intelligence gathering  Academic Article
  • The true structures of the vannusals, part 2: Total synthesis and revised structure of vannusal B  Academic Article
  • Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase  Academic Article
  • Thermodynamic resolution: how do errors in modeled protein structures affect binding affinity predictions?  Academic Article
  • Three clusters of conformational states in p450cam reveal a multistep pathway for closing of the substrate access channel  Academic Article
  • Three-dimensional model of the human platelet integrin alpha(llb)beta(3) based on electron cryomicroscopy and x-ray crystallography  Academic Article
  • Three-dimensional structure of a viral genome-delivery portal vertex  Academic Article
  • Three-dimensional structure of brush border myosin-i at similar to 20 Å resolution by electron microscopy and image analysis  Academic Article
  • Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin  Academic Article
  • Three-dimensional structure of the bacteriophage p22 tail machine  Academic Article
  • Three-dimensional structure of the ephb2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition  Academic Article
  • Three-dimensional structure of the m-mulv ca protein on a lipid monolayer: A general model for retroviral capsid assembly  Academic Article
  • Through-bond/through-space anion relay chemistry exploiting vinylepoxides as bifunctional linchpins  Academic Article
  • Time-resolved molecular dynamics of bacteriophage hk97 capsid maturation interpreted by electron cryo-microscopy and x-ray crystallography  Academic Article
  • Titanium(IV) isopropoxide mediated synthesis of pyrimidin-4-ones  Academic Article
  • Titanium(IV)-mediated tandem deprotection-cyclodehydration of protected cysteine N-amides: biomimetic syntheses of thiazoline- and thiazole-containing heterocycles  Academic Article
  • Tm0486 from the hyperthermophilic anaerobe thermotoga maritima is a thiamin-binding protein involved in response of the cell to oxidative conditions  Academic Article
  • Topologically linked protein rings in the bacteriophage hk97 capsid  Academic Article
  • Total Synthesis of lleabethoxazole, pseudopteroxazole, and seco-pseudopteroxazole  Academic Article
  • Total chemical synthesis of enzymatically active human type II secretory phospholipase A2  Academic Article
  • Total syntheses of 2,2 '-epi-cytoskyrin a, rugulosin, and the alleged structure of rugulin  Academic Article
  • Total synthesis and structural elucidation of azaspiracid-1. Construction of key building blocks for originally proposed structure  Academic Article
  • Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product  Academic Article
  • Total synthesis and structural revision of antibiotic CJ-16,264  Academic Article
  • Total synthesis and structural revision of biyouyanagin B  Academic Article
  • Total synthesis and structural revision of vannusals A and B: synthesis of the true structures of vannusals A and B  Academic Article
  • Total synthesis of (+/-)- and (-)-actinophyllic acid  Academic Article
  • Total synthesis of (+/-)-haouamine A  Academic Article
  • Total synthesis of abyssomicin c and atrop-abyssomicin c  Academic Article
  • Total synthesis of abyssomicin c, atrop-abyssomicin c, and abyssomicin d: Implications for natural origins of atrop-abyssomicin c  Academic Article
  • Total synthesis of chlorofusin, its seven chromophore diastereomers, and key partial structures  Academic Article
  • Total synthesis of colombiasin a and determination of its absolute configuration  Academic Article
  • Total synthesis of everninomicin 13,384-1 - part 2: Synthesis of the fgha(2) fragment  Academic Article
  • Total synthesis of hirsutellone B  Academic Article
  • Total synthesis of marinomycins A-C  Academic Article
  • Total synthesis of piericidin A1 and B1 and key analogues  Academic Article
  • Total synthesis of platencin  Academic Article
  • Total synthesis of the originally assigned structure of vannusal B  Academic Article
  • Total synthesis of vinigrol  Academic Article
  • Total synthesis, revised structure, and biological evaluation of biyouyanagin A and analogues thereof  Academic Article
  • Toward a chemical mechanism of proton pumping by the B-type cytochrome c oxidases: application of density functional theory to cytochrome ba(3) of Thermus thermophilus  Academic Article
  • Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies  Academic Article
  • Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies  Academic Article
  • Toward understanding the structure and interactions of microtubules and motor proteins  Academic Article
  • Towards protein-crystal centering using second-harmonic generation (SHG) microscopy  Academic Article
  • Towards structure-based drug design - crystal-structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 Å resolution  Academic Article
  • Transcription inactivation through local refolding of the RNA polymerase structure  Academic Article
  • Trapping a transition state in a computationally designed protein bottle  Academic Article
  • Trapping the dynamic acyl carrier protein in fatty acid biosynthesis  Academic Article
  • Triggering and monitoring light-sensing reactions in protein crystals  Academic Article
  • Trypsin inhibitors for the treatment of pancreatitis  Academic Article
  • Tryptophan-accelerated electron flow through proteins  Academic Article
  • Tuning assembly size in peptide-based supramolecular polymers by modulation of subunit association affinity  Academic Article
  • Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (h-nox) domain  Academic Article
  • Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope  Academic Article
  • Two conformations of RNA polymerase II revealed by electron crystallography  Academic Article
  • Two conformations of a crystalline human tRNA synthetase–tRNA complex: implications for protein synthesis  Academic Article
  • Two different, highly exposed, bulged structures for an unusually long peptide bound to rat mhc class i rt1-a(a)  Academic Article
  • Two novel SOD1 mutations in patients with familial amyotrophic lateral sclerosis  Academic Article
  • Two-dimensional crystallization of streptavidin: In pursuit of the molecular origins of structure, morphology, and thermodynamics  Academic Article
  • Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin  Academic Article
  • Type iv pilus structure and bacterial pathogenicity  Academic Article
  • Type iv pilus structure by cryo-electron microscopy and crystallography: Implications for pilus assembly and functions  Academic Article
  • Type-4 pilus-structure: Outside to inside and top to bottom - a minireview  Academic Article
  • Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2N-SH2-domain phosphotyrosine-peptide binding cleft  Academic Article
  • Tyrosine kinase 2-mediated signal transduction in T lymphocytes is blocked by pharmacological stabilization of Its pseudokinase domain  Academic Article
  • UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries  Academic Article
  • Ultrahigh and high resolution structures and mutational analysis of monomeric streptococcus pyogenes speb reveal a functional role for the glycine-rich c-terminal loop  Academic Article
  • Ultrahigh resolution and full-length pilin structures with insights for filament assembly, pathogenic functions, and vaccine potential  Academic Article
  • Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation  Academic Article
  • Understanding GFP chromophore biosynthesis: Controlling backbone cyclization and modifying post-translational chemistry  Academic Article
  • Understanding GFP posttranslational chemistry: Structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation  Academic Article
  • Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1  Academic Article
  • Understanding the mechanism of H(+)-induced demetalation as a design strategy for robust iron(III) peroxide-activating catalysts  Academic Article
  • Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome  Academic Article
  • Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase  Academic Article
  • Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor  Academic Article
  • Unique domain appended to vertebrate tRNA synthetase is essential for vascular development  Academic Article
  • Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange  Academic Article
  • Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin  Academic Article
  • Unnatural amino acid mutagenesis of fluorescent proteins  Academic Article
  • Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease iv  Academic Article
  • Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein lb  Academic Article
  • Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase  Academic Article
  • Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects  Academic Article
  • Uranyl ion coordination with rigid aromatic carboxylates and structural characterization of their complexes  Academic Article
  • Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1  Academic Article
  • Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1 beta  Academic Article
  • Using AutoDock for ligand-receptor docking  Academic Article
  • Using a quasi-parallel x-ray beam of ultrashort wavelength for high-pressure virus crystallography: Implications for standard macromolecular crystallography  Academic Article
  • Using antibodies to perturb the coordination sphere of a transition metal complex  Academic Article
  • Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors  Academic Article
  • Versatile approach for the synthesis of novel seven-membered iminocyclitols via ring-closing metathesis dihydroxylation reaction  Academic Article
  • Versatile approaches for the synthesis of fused-ring γ-lactones utilizing cyclopropane intermediates  Academic Article
  • Vinculin activation by talin through helical bundle conversion  Academic Article
  • Vinculin binding in its closed conformation by a helix addition mechanism  Academic Article
  • Virtual screening against acetylcholine binding protein  Academic Article
  • Virus maturation involving large subunit rotations and local refolding  Academic Article
  • Virus-like particles of a fish nodavirus display a capsid subunit domain organization different from that of insect nodaviruses  Academic Article
  • Visualization of macromolecular structures  Academic Article
  • Water--more than just a green solvent: a stereoselective one-pot access to all-chiral tetrahydronaphthalenes in aqueous media  Academic Article
  • Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets  Academic Article
  • Why does TNA cross-pair more strongly with RNA than with DNA? An answer from X-ray analysis  Academic Article
  • Wrn exonuclease structure and molecular mechanism imply an editing role in DNA end processing  Academic Article
  • X-ray crystal structure of the cytochrome p450 2b4 active site mutant f297a in complex with clopidogrel: Insights into compensatory rearrangements of the binding pocket  Academic Article
  • X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli  Academic Article
  • X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase  Academic Article
  • X-ray crystallographic determination of the structure of the influenza c virus haemagglutinin-esterase-fusion glycoprotein  Academic Article
  • X-ray diffraction analysis of a crystal of HscA from Escherichia coli  Academic Article
  • X-ray solution scattering (saxs) combined with crystallography and computation: Defining accurate macromolecular structures, conformations and assemblies in solution  Academic Article
  • X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus  Academic Article
  • X-ray structure of emre supports dual topology model  Academic Article
  • X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease  Academic Article
  • X-ray structure of influenza virus NS1 effector domain  Academic Article
  • X-ray structure of junctional adhesion molecule: Structural basis for homophilic adhesion via a novel dimerization motif  Academic Article
  • X-ray structures of the LXRα LBD in its homodimeric form and implications for heterodimer signaling  Academic Article
  • X-ray structures of the hexameric building block of the HIV capsid  Academic Article
  • X-shaped structure of bacterial heterotetrameric tRNA synthetase suggests cryptic prokaryote functions and a rationale for synthetase classifications  Academic Article
  • Xiap induces nf-kappa b activation via the bir1/tab1 interaction and bir1 dimerization  Academic Article
  • Xol-1, primary determinant of sexual fate in c. Elegans, is a ghmp kinase family member and a structural prototype for a class of developmental regulators  Academic Article
  • Xpd helicase structures and activities: Insights into the cancer and aging phenotypes from xpd mutations  Academic Article
  • Xrcc4 protein interactions with xrcc4-like factor (xlf) create an extended grooved scaffold for DNA ligation and double strand break repair  Academic Article
  • Yatakemycin: Total synthesis, DNA alkylation, and biological properties  Academic Article
  • Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB  Academic Article
  • alpha-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain  Academic Article
  • gamma H2A binds Brc1 to maintain genome integrity during S-phase  Academic Article
  • gp41: HIV's shy protein  Academic Article
  • p RCSB Protein Data Bank resources for structure-facilitated design of mRNA vaccines for existing and emerging viral pathogens  Academic Article
  • p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses  Academic Article
  • tRNA structure goes from L to lambda  Academic Article
  • tRNA-controlled nuclear import of a human tRNA synthetase  Academic Article
  • αβ T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization  Academic Article

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