subject area of
- A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells Academic Article
- A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells Academic Article
- A novel 2 '-(n-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models Academic Article
- A total synthesis trilogy: Calicheamicin gamma 1i, taxol (r), and brevetoxin a Academic Article
- Analysis of human cytochrome P4502C8 substrate specificity using a substrate pharmacophore and site-directed mutants Academic Article
- Annonacin, a natural mitochondrial complex i inhibitor, causes tau pathology in cultured neurons Academic Article
- Antitumor efficacy of 26-fluoroepothilone b against human prostate cancer xenografts Academic Article
- Catalytic asymmetric aminohydroxylation provides a short taxol side-chain synthesis Academic Article
- Changes in the extent of microtubule assembly can regulate initiation of DNA-synthesis Academic Article
- Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site Academic Article
- Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites Academic Article
- Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site Academic Article
- Design, synthesis and biological-activity of protaxols Academic Article
- Design, synthesis, and biological properties of highly potent epothilone b analogues Academic Article
- Effects of the herbal extract PC-SPES on microtubule dynamics and paclitaxel-mediated prostate tumor growth inhibition Academic Article
- Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics Academic Article
- Epothilones: From discovery to clinical trials Academic Article
- Evaluation of novel epothilone analogues by means of a common pharmacophore and a QSAR pseudoreceptor model for taxanes and epothilones Academic Article
- Evidence that microtubule depolymerization early in the cell-cycle is sufficient to initiate DNA-synthesis Academic Article
- Fluorescent taxoids Academic Article
- High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis Academic Article
- Inspirations, discoveries, and future perspectives in total synthesis Academic Article
- Interaction of epothilone analogs with the paclitaxel binding site: Relationship between binding affinity, microtubule stabilization, and cytotoxicity Academic Article
- Kinesin follows the microtubules protofilament axis Academic Article
- Microtubule stabilization by taxol inhibits initiation of DNA-synthesis by thrombin and by epidermal growth-factor Academic Article
- Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells Academic Article
- Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: A gynecologic oncology group study Academic Article
- Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs Academic Article
- Randomized phase II trial of Seribantumab in combination with paclitaxel in patients with advanced platinum-resistant or - refractory ovarian cancer Academic Article
- Samarium diiodide mediated reactions in total synthesis Academic Article
- Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma Academic Article
- Solid-phase combinatorial synthesis using microkan reactors, rf tagging, and directed sorting Academic Article
- Sperm associated antigen 6 (SPAG6) regulates fibroblast cell growth, morphology, migration and ciliogenesis Academic Article
- Stepwise orthogonal click chemistry toward fabrication of paclitaxel/galactose functionalized fluorescent nanoparticles for HepG2 cell targeting and delivery Academic Article
- Synergistic effects of peloruside a and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly Academic Article
- Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents Academic Article
- Targeting heat shock proteins on cancer cells: Selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand Academic Article
- Taxoids: New weapons against cancer Academic Article
- The coral-derived natural products eleutherobin and sarcodictyins a and b: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site Academic Article
- Total synthesis of taxol Academic Article
- Tubulin gtp hydrolysis influences the structure, mechanical-properties, and kinesin driven transport of microtubules Academic Article
- Two-phase synthesis of (-)-taxuyunnanine D Academic Article
- USP15 negatively regulates Nrf2 through deubiquitination of Keap1 Academic Article