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Paclitaxel

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  • A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells  Academic Article
  • A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells  Academic Article
  • A novel 2 '-(n-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models  Academic Article
  • A total synthesis trilogy: Calicheamicin gamma 1i, taxol (r), and brevetoxin a  Academic Article
  • Analysis of human cytochrome P4502C8 substrate specificity using a substrate pharmacophore and site-directed mutants  Academic Article
  • Annonacin, a natural mitochondrial complex i inhibitor, causes tau pathology in cultured neurons  Academic Article
  • Antitumor efficacy of 26-fluoroepothilone b against human prostate cancer xenografts  Academic Article
  • Catalytic asymmetric aminohydroxylation provides a short taxol side-chain synthesis  Academic Article
  • Changes in the extent of microtubule assembly can regulate initiation of DNA-synthesis  Academic Article
  • Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site  Academic Article
  • Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites  Academic Article
  • Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site  Academic Article
  • Design, synthesis and biological-activity of protaxols  Academic Article
  • Design, synthesis, and biological properties of highly potent epothilone b analogues  Academic Article
  • Effects of the herbal extract PC-SPES on microtubule dynamics and paclitaxel-mediated prostate tumor growth inhibition  Academic Article
  • Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics  Academic Article
  • Epothilones: From discovery to clinical trials  Academic Article
  • Evaluation of novel epothilone analogues by means of a common pharmacophore and a QSAR pseudoreceptor model for taxanes and epothilones  Academic Article
  • Evidence that microtubule depolymerization early in the cell-cycle is sufficient to initiate DNA-synthesis  Academic Article
  • Fluorescent taxoids  Academic Article
  • High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis  Academic Article
  • Inspirations, discoveries, and future perspectives in total synthesis  Academic Article
  • Interaction of epothilone analogs with the paclitaxel binding site: Relationship between binding affinity, microtubule stabilization, and cytotoxicity  Academic Article
  • Kinesin follows the microtubules protofilament axis  Academic Article
  • Microtubule stabilization by taxol inhibits initiation of DNA-synthesis by thrombin and by epidermal growth-factor  Academic Article
  • Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells  Academic Article
  • Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: A gynecologic oncology group study  Academic Article
  • Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs  Academic Article
  • Randomized phase II trial of Seribantumab in combination with paclitaxel in patients with advanced platinum-resistant or - refractory ovarian cancer  Academic Article
  • Samarium diiodide mediated reactions in total synthesis  Academic Article
  • Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma  Academic Article
  • Solid-phase combinatorial synthesis using microkan reactors, rf tagging, and directed sorting  Academic Article
  • Sperm associated antigen 6 (SPAG6) regulates fibroblast cell growth, morphology, migration and ciliogenesis  Academic Article
  • Stepwise orthogonal click chemistry toward fabrication of paclitaxel/galactose functionalized fluorescent nanoparticles for HepG2 cell targeting and delivery  Academic Article
  • Synergistic effects of peloruside a and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly  Academic Article
  • Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents  Academic Article
  • Targeting heat shock proteins on cancer cells: Selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand  Academic Article
  • Taxoids: New weapons against cancer  Academic Article
  • The coral-derived natural products eleutherobin and sarcodictyins a and b: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site  Academic Article
  • Total synthesis of taxol  Academic Article
  • Tubulin gtp hydrolysis influences the structure, mechanical-properties, and kinesin driven transport of microtubules  Academic Article
  • Two-phase synthesis of (-)-taxuyunnanine D  Academic Article
  • USP15 negatively regulates Nrf2 through deubiquitination of Keap1  Academic Article

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