subject area of

• A general approach to site-specific antibody drug conjugates  Academic Article
• A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival  Academic Article
• A new method of embryonic culture for assessing global changes in brain organization  Academic Article
• A novel neuroprotective agent with antioxidant and nitric oxide synthase inhibitory action  Academic Article
• A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds  Academic Article
• A reevaluation of tetraploidy in the Alzheimer's disease brain  Academic Article
• A role for c-myc in chemically induced renal-cell death  Academic Article
• Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss  Academic Article
• Accelerated, aging-dependent development of osteoarthritis in alpha 1 integrin-deficient mice  Academic Article
• Activation of HIPK2 promotes ER stress-mediated neurodegeneration in amyotrophic lateral sclerosis  Academic Article
• Activation of lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury  Academic Article
• Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development  Academic Article
• Annonacin, a natural mitochondrial complex i inhibitor, causes tau pathology in cultured neurons  Academic Article
• Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists  Academic Article
• Antigen presentation and cytotoxic t-lymphocyte killing studied in individual, living cells  Academic Article
• Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells  Academic Article
• Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis  Academic Article
• BAG1 over-expression in brain protects against stroke  Academic Article
• Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin  Academic Article
• Bcl-2-induced changes in E2F regulatory complexes reveal the potential for integrated cell cycle and cell death functions  Academic Article
• Bcr ligation induces receptor editing in igm(+)igd(-) bone marrow b cells in vitro  Academic Article
• Beta 1 integrins regulate myoblast fusion and sarcomere assembly  Academic Article
• Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death  Academic Article
• Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors  Academic Article
• Blocking c-jun n-terminal kinase (jnk) translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo  Academic Article
• Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis  Academic Article
• Brassinosteroids modulate the efficiency of plant immune responses to microbe-associated molecular patterns  Academic Article
• Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax  Academic Article
• C-myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways  Academic Article
• CD19 and CD32b differentially regulate human B cell responsiveness  Academic Article
• Calcium tsunamis: do astrocytes transmit cell death messages via gap junctions during ischemia?  Academic Article
• Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis  Academic Article
• Catalytically active single-chain polymeric nanoparticles: exploring their functions in complex biological media  Academic Article
• Cell death  Academic Article
• Cell death in cartilage  Academic Article
• Cell death, DNA breaks and possible rearrangements: an alternative view  Academic Article
• Cell death, autoantigen cleavage, and autoimmunity  Academic Article
• Cell death: protein misfolding and neurodegenerative diseases  Academic Article
• Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death  Academic Article
• Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009  Academic Article
• Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model  Academic Article
• Constitutive c-myc expression in an il-3-dependent myeloid cell-line suppresses cell-cycle arrest and accelerates apoptosis  Academic Article
• Continuous directed evolution of receptor-selective alpha-endotoxins for overcoming insecticidal resistance  Academic Article
• Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels  Academic Article
• Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide  Academic Article
• Cytochrome oxidase deficiency protects Escherichia coli from cell death but not from filamentation due to thymine deficiency or DNA polymerase inactivation  Academic Article
• Cytotoxicity of a Ti(IV) compound is independent of serum proteins  Academic Article
• Deconstructing transcriptional heterogeneity in pluripotent stem cells  Academic Article
• Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1  Academic Article
• Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively  Academic Article
• Differential target cell sensitivity to CTL-activated death pathways in hepatitis B virus transgenic mice  Academic Article
• Direct delivery of bacterial avirulence proteins into resistant Arabidopsis protoplasts leads to hypersensitive cell death  Academic Article
• Dueling activities of AIF in cell death versus survival: DNA binding and redox activity  Academic Article
• ERK and cell death: ERK1/2 in neuronal death  Academic Article
• Effect of osteochondral graft insertion forces on chondrocyte viability  Academic Article
• Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression  Academic Article
• Emerging role of protein-protein transnitrosylation in cell signaling pathways  Academic Article
• Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases  Academic Article
• Enhanced neuronal death from focal ischemia in AMPA-receptor transgenic mice  Academic Article
• Enzyme kinetics and interaction studies for human jnk1 beta 1 and substrates activating transcription factor 2 (atf2) and c-jun n-terminal kinase (c-jun)  Academic Article
• Eucommia ulmoides oliv. Bark. Protects against hydrogen peroxide-induced neuronal cell death in sh-sy5y cells  Academic Article
• Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death  Academic Article
• Expression of amino-terminally truncated prp in the mouse leading to ataxia and specific cerebellar lesions  Academic Article
• Expression of truncated prp targeted to purkinje cells of prp knockout mice causes purkinje cell death and ataxia  Academic Article
• Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments  Academic Article
• Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death  Academic Article
• Fatty acid amide hydrolase determines anandamide-induced cell death in the liver  Academic Article
• Flavonoids protect retinal ganglion cells from ischemia in vitro  Academic Article
• Functional amyloidogenesis and cytotoxicity: insights into biology and pathology  Academic Article
• Gene expression profiling of r6/2 transgenic mice with different cag repeat lengths reveals genes associated with disease onset and progression in huntington's disease  Academic Article
• Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity  Academic Article
• Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers  Academic Article
• Glucose regulated proteins 78 protects insulinoma cells (NIT-1) from death induced by streptozotocin, cytokines or cytotoxic T lymphocytes  Academic Article
• Glutamate activates NF-kappa B through calpain in neurons  Academic Article
• Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity  Academic Article
• Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death  Academic Article
• Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways  Academic Article
• Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes  Academic Article
• HBsAg retention sensitizes the hepatocyte to injury by physiological concentrations of interferon‐γ  Academic Article
• HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection  Academic Article
• HIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2  Academic Article
• HIV-related neurotoxicity  Academic Article
• High-affinity ligand probes of cd22 overcome the threshold set by cis ligands for binding, endocytosis, and killing of b cells  Academic Article
• Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication  Academic Article
• Human immunodeficiency virus-infected macrophages, gp120, and N-methyl-D-aspartate receptor-mediated neurotoxicity  Academic Article
• IKK beta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis  Academic Article
• IKK/NF-kappaB signaling: balancing life and death - a new approach to cancer therapy  Academic Article
• In vitro and in vivo anticancer activity of a synthetic glycolipid as Toll-like receptor 4 (TLR4) activator  Academic Article
• Inability of il-2 and il-10 to counteract b-cell clonal deletion  Academic Article
• Inability of serum myocyte death markers to predict acute cardiac allograft rejection  Academic Article
• Inactivation of the p53 pathway in retinoblastoma  Academic Article
• Inflammatory mediators leading to protein misfolding and uncompetitive/fast off-rate drug therapy for neurodegenerative disorders  Academic Article
• Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats  Academic Article
• Inhibition of beta-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library  Academic Article
• Inhibition of protocadherin-alpha function results in neuronal death in the developing zebrafish  Academic Article
• Interleukin-1 beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases  Academic Article
• Interleukin-6 produces neuronal loss in developing cerebellar granule neuron cultures  Academic Article
• Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons  Academic Article
• Involvement of b lymphocytes in the growth inhibition of human pulmonary melanoma metastases in athymic nu/nu mice by in antibody-lymphotoxin fusion protein  Academic Article
• Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death  Academic Article
• Janus faces of NF-κB: Neurodestruction versus neuroprotection  Academic Article
• Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice  Academic Article
• Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer  Academic Article
• Lymphoproliferative disease and autoimmunity in mice with increased mir-17-92 expression in lymphocytes  Academic Article
• Macrophages kill capillary cells in G1 phase of the cell cycle during programmed vascular regression  Academic Article
• Mammalian polymerase theta promotes alternative NHEJ and suppresses recombination  Academic Article
• Mathematical modeling supports substantial mouse neural progenitor cell death  Academic Article
• Mdm4 (mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development  Academic Article
• Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection  Academic Article
• Mechanism of cell death caused by complex i defects in a rat dopaminergic cell line  Academic Article
• Mechanism of toxicity in rotenone models of parkinson's disease  Academic Article
• Mechanism of toxicity of pesticides acting at complex i: Relevance to environmental etiologies of parkinson's disease  Academic Article
• Mechanisms of sodium nitroprusside-induced death in human chondrocytes  Academic Article
• Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition  Academic Article
• Metaxin is required for tumor necrosis factor-induced cell death  Academic Article
• Methamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus  Academic Article
• Mir-150 controls b cell differentiation by targeting the transcription factor c-myb  Academic Article
• Misexpression of the eyes absent family triggers the apoptotic program  Academic Article
• Mitochondrial dynamics in cell death and neurodegeneration  Academic Article
• Mitochondrial fission is an upstream and required event for Bax foci formation in response to nitric oxide in cortical neurons  Academic Article
• Molecular basis of glutamate toxicity in retinal ganglion cells  Academic Article
• Molecular mechanisms of nitrosative stress-mediated protein misfolding in neurodegenerative diseases  Academic Article
• Molecular medicine and neurodegenerative diseases  Academic Article
• Myocyte protection by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of the Ras GTP-ase pathway  Academic Article
• Naturally death-resistant precursor cells revealed as the origin of retinoblastoma  Academic Article
• Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice  Academic Article
• Neurogenesis and commitment of corticospinal neurons in reeler  Academic Article
• Neuronal death induced by misfolded prion protein is due to NAD(+) depletion and can be relieved in vitro and in vivo by NAD(+) replenishment  Academic Article
• Neuronal protection and destruction by NO  Academic Article
• Neuroprotection by the NR3A subunit of the NMDA receptor  Academic Article
• No immune responses by the expression of the yeast ndi1 protein in rats  Academic Article
• Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding  Academic Article
• Obligatory role for complex i inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)  Academic Article
• Osteopontin expression in the brain triggers localized inflammation and cell death when immune cells are activated by pertussis toxin  Academic Article
• Paradigm shift in NMDA receptor antagonist drug development: Molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders  Academic Article
• Peptidylariginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates  Academic Article
• Perception of brassinosteroids by the extracellular domain of the receptor kinase BRI1  Academic Article
• Periadolescent ethanol vapor exposure persistently reduces measures of hippocampal neurogenesis that are associated with behavioral outcomes in adulthood  Academic Article
• Peripheral deletion of self-reactive b-cells  Academic Article
• Pharmacokinetics and efficacy of the spleen tyrosine kinase inhibitor r406 after ocular delivery for retinoblastoma  Academic Article
• Precursor thymocyte proliferation and differentiation are controlled by signals unrelated to the pre-TCR  Academic Article
• Prolonged waking reduces human immunodeficiency virus glycoprotein 120- or tumor necrosis factor alpha-induced apoptosis in the cerebral cortex of rats  Academic Article
• Protective effects of 6-ureido/thioureido-2,4,5-trimethylpyridin-3-ols against 4-hydroxynonenal-induced cell death in adult retinal pigment epithelial-19 cells  Academic Article
• Protective effects of heme oxygenase-1 against mpp(+)-induced cytotoxicity in pc-12 cells  Academic Article
• RIG-I enhanced interferon independent apoptosis upon Junin virus infection  Academic Article
• Ratio of S-nitrosohomocyst(e)ine to homocyst(e)ine or other thiols determines neurotoxicity in rat cerebrocortical cultures  Academic Article
• Rearranging views on neurogenesis: Neuronal death in the absence of DNA end-joining proteins  Academic Article
• Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases  Academic Article
• Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases  Academic Article
• Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress  Academic Article
• Responses of microRNAs 124a and 223 following spinal cord injury in mice  Academic Article
• Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity  Academic Article
• Ricin cytotoxicity is sensitive to recycling between the endoplasmic-reticulum and the Golgi-complex  Academic Article
• Role of transient receptor potential channel 1 (TRPC1) in glutamate-induced cell death in the hippocampal cell line HT22  Academic Article
• S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease  Academic Article
• Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival  Academic Article
• Selective inhibition of mitochondrial jnk signaling achieved using peptide mimicry of the sab kinase interacting motif-1 (kim1)  Academic Article
• Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha  Academic Article
• Sensory neuronal phenotype in galanin receptor 2 knockout mice: Focus on dorsal root ganglion neurone development and pain behaviour  Academic Article
• Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in Fragile X-associated tremor/ataxia syndrome  Academic Article
• Serum- and glucocorticoid-inducible kinase 1 confers protection in cell-based and in in vivo neurotoxin models via the c-Jun N-terminal kinase signaling pathway  Academic Article
• Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer  Academic Article
• Signaling t-cell survival and death by il-2 and il-15  Academic Article
• Signalling for survival and death in neurones - the role of stress-activated kinases, jnk and p38  Academic Article
• Similarity of neuronal cell injury and death in AIDS dementia and focal cerebral ischemia: Potential treatment with NMDA open-channel blockers and nitric oxide-related species  Academic Article
• Simultaneous intracellular calcium and sodium flux imaging in human vanilloid receptor 1 (VR1)-transfected human embryonic kidney cells: A method to resolve ionic dependence of VR1-mediated cell death  Academic Article
• Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus  Academic Article
• Structure activity studies of a novel cytotoxic benzodiazepine  Academic Article
• Sulfuretin inhibits 6-hydroxydopamine-induced neuronal cell death via reactive oxygen species-dependent mechanisms in human neuroblastoma SH-SY5Y cells  Academic Article
• Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models  Academic Article
• Suppression of c-myc expression and c-myc function in response to sustained DNA damage in mcf-7 breast tumor cells  Academic Article
• Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor  Academic Article
• Synthesis of key sandramycin analogs: Systematic examination of the intercalation chromophore  Academic Article
• TNFR1/phox interaction and TNFR1 mitochondrial translocation Thwart silica-induced pulmonary fibrosis  Academic Article
• Targeted disruption of the Artemis murine counterpart results in SCID and defective V(D)J recombination that is partially corrected with bone marrow transplantation  Academic Article
• The activity-dependent histone variant H2BE modulates the life span of olfactory neurons  Academic Article
• The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-beta-mediated antiviral activity in vitro and in vivo  Academic Article
• The anticancer ruthenium complex KP1019 induces DNA damage, leading to cell cycle delay and cell death in Saccharomyces cerevisiae  Academic Article
• The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death  Academic Article
• The autoimmunity-inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular and antigenic properties  Academic Article
• The c-jun-n-terminal kinase is involved in the neurotoxic effect of azaspiracid-1  Academic Article
• The contribution of various NOS gene products to HIV-1 coat protein (gp120)-mediated retinal ganglion cell injury  Academic Article
• The df-1 chicken fibroblast cell line: Transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses  Academic Article
• The effect of glycosaminoglycan loss on chondrocyte viability: a study on porcine cartilage explants  Academic Article
• The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity  Academic Article
• The polyamine oxidase inhibitor mdl-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects  Academic Article
• The temporal expression patterns of fibronectin and its receptors-α5β1 and αvβ3 integrins on blood vessels after cerebral ischemia  Academic Article
• Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival  Academic Article
• Tid1 is required for T cell transition from double-negative 3 to double-positive stages  Academic Article
• Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons  Academic Article
• Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death  Academic Article
• Transforming growth factor-beta 1 increases survival of human melanoma through stroma remodeling  Academic Article
• Upregulation of fibronectin and the α5β1 and αvβ3 integrins on blood vessels within the cerebral ischemic penumbra  Academic Article
• Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis  Academic Article
• Viral rna induces type i interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5 implications for viral infection-associated glomerulonephritis  Academic Article
• [HIV glycoprotein 120: possible etiological agent of AIDS-associated dementia] [Article in Spanish]  Academic Article