subject area of
- A general approach to site-specific antibody drug conjugates Academic Article
- A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival Academic Article
- A new method of embryonic culture for assessing global changes in brain organization Academic Article
- A novel neuroprotective agent with antioxidant and nitric oxide synthase inhibitory action Academic Article
- A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds Academic Article
- A reevaluation of tetraploidy in the Alzheimer's disease brain Academic Article
- A role for c-myc in chemically induced renal-cell death Academic Article
- Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss Academic Article
- Accelerated, aging-dependent development of osteoarthritis in alpha 1 integrin-deficient mice Academic Article
- Activation of HIPK2 promotes ER stress-mediated neurodegeneration in amyotrophic lateral sclerosis Academic Article
- Activation of lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury Academic Article
- Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development Academic Article
- Annonacin, a natural mitochondrial complex i inhibitor, causes tau pathology in cultured neurons Academic Article
- Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists Academic Article
- Antigen presentation and cytotoxic t-lymphocyte killing studied in individual, living cells Academic Article
- Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells Academic Article
- Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis Academic Article
- BAG1 over-expression in brain protects against stroke Academic Article
- Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin Academic Article
- Bcl-2-induced changes in E2F regulatory complexes reveal the potential for integrated cell cycle and cell death functions Academic Article
- Bcr ligation induces receptor editing in igm(+)igd(-) bone marrow b cells in vitro Academic Article
- Beta 1 integrins regulate myoblast fusion and sarcomere assembly Academic Article
- Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death Academic Article
- Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors Academic Article
- Blocking c-jun n-terminal kinase (jnk) translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo Academic Article
- Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis Academic Article
- Brassinosteroids modulate the efficiency of plant immune responses to microbe-associated molecular patterns Academic Article
- Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax Academic Article
- C-myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways Academic Article
- CD19 and CD32b differentially regulate human B cell responsiveness Academic Article
- Calcium tsunamis: do astrocytes transmit cell death messages via gap junctions during ischemia? Academic Article
- Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis Academic Article
- Catalytically active single-chain polymeric nanoparticles: exploring their functions in complex biological media Academic Article
- Cell death Academic Article
- Cell death in cartilage Academic Article
- Cell death, DNA breaks and possible rearrangements: an alternative view Academic Article
- Cell death, autoantigen cleavage, and autoimmunity Academic Article
- Cell death: protein misfolding and neurodegenerative diseases Academic Article
- Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death Academic Article
- Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 Academic Article
- Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model Academic Article
- Constitutive c-myc expression in an il-3-dependent myeloid cell-line suppresses cell-cycle arrest and accelerates apoptosis Academic Article
- Continuous directed evolution of receptor-selective alpha-endotoxins for overcoming insecticidal resistance Academic Article
- Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels Academic Article
- Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide Academic Article
- Cytochrome oxidase deficiency protects Escherichia coli from cell death but not from filamentation due to thymine deficiency or DNA polymerase inactivation Academic Article
- Cytotoxicity of a Ti(IV) compound is independent of serum proteins Academic Article
- Deconstructing transcriptional heterogeneity in pluripotent stem cells Academic Article
- Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1 Academic Article
- Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively Academic Article
- Differential target cell sensitivity to CTL-activated death pathways in hepatitis B virus transgenic mice Academic Article
- Direct delivery of bacterial avirulence proteins into resistant Arabidopsis protoplasts leads to hypersensitive cell death Academic Article
- Dueling activities of AIF in cell death versus survival: DNA binding and redox activity Academic Article
- ERK and cell death: ERK1/2 in neuronal death Academic Article
- Effect of osteochondral graft insertion forces on chondrocyte viability Academic Article
- Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression Academic Article
- Emerging role of protein-protein transnitrosylation in cell signaling pathways Academic Article
- Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases Academic Article
- Enhanced neuronal death from focal ischemia in AMPA-receptor transgenic mice Academic Article
- Enzyme kinetics and interaction studies for human jnk1 beta 1 and substrates activating transcription factor 2 (atf2) and c-jun n-terminal kinase (c-jun) Academic Article
- Eucommia ulmoides oliv. Bark. Protects against hydrogen peroxide-induced neuronal cell death in sh-sy5y cells Academic Article
- Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death Academic Article
- Expression of amino-terminally truncated prp in the mouse leading to ataxia and specific cerebellar lesions Academic Article
- Expression of truncated prp targeted to purkinje cells of prp knockout mice causes purkinje cell death and ataxia Academic Article
- Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments Academic Article
- Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death Academic Article
- Fatty acid amide hydrolase determines anandamide-induced cell death in the liver Academic Article
- Flavonoids protect retinal ganglion cells from ischemia in vitro Academic Article
- Functional amyloidogenesis and cytotoxicity: insights into biology and pathology Academic Article
- Gene expression profiling of r6/2 transgenic mice with different cag repeat lengths reveals genes associated with disease onset and progression in huntington's disease Academic Article
- Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity Academic Article
- Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers Academic Article
- Glucose regulated proteins 78 protects insulinoma cells (NIT-1) from death induced by streptozotocin, cytokines or cytotoxic T lymphocytes Academic Article
- Glutamate activates NF-kappa B through calpain in neurons Academic Article
- Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity Academic Article
- Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death Academic Article
- Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways Academic Article
- Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes Academic Article
- HBsAg retention sensitizes the hepatocyte to injury by physiological concentrations of interferon‐γ Academic Article
- HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection Academic Article
- HIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2 Academic Article
- HIV-related neurotoxicity Academic Article
- High-affinity ligand probes of cd22 overcome the threshold set by cis ligands for binding, endocytosis, and killing of b cells Academic Article
- Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication Academic Article
- Human immunodeficiency virus-infected macrophages, gp120, and N-methyl-D-aspartate receptor-mediated neurotoxicity Academic Article
- IKK beta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis Academic Article
- IKK/NF-kappaB signaling: balancing life and death - a new approach to cancer therapy Academic Article
- In vitro and in vivo anticancer activity of a synthetic glycolipid as Toll-like receptor 4 (TLR4) activator Academic Article
- Inability of il-2 and il-10 to counteract b-cell clonal deletion Academic Article
- Inability of serum myocyte death markers to predict acute cardiac allograft rejection Academic Article
- Inactivation of the p53 pathway in retinoblastoma Academic Article
- Inflammatory mediators leading to protein misfolding and uncompetitive/fast off-rate drug therapy for neurodegenerative disorders Academic Article
- Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats Academic Article
- Inhibition of beta-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library Academic Article
- Inhibition of protocadherin-alpha function results in neuronal death in the developing zebrafish Academic Article
- Interleukin-1 beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases Academic Article
- Interleukin-6 produces neuronal loss in developing cerebellar granule neuron cultures Academic Article
- Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons Academic Article
- Involvement of b lymphocytes in the growth inhibition of human pulmonary melanoma metastases in athymic nu/nu mice by in antibody-lymphotoxin fusion protein Academic Article
- Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death Academic Article
- Janus faces of NF-κB: Neurodestruction versus neuroprotection Academic Article
- Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice Academic Article
- Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer Academic Article
- Lymphoproliferative disease and autoimmunity in mice with increased mir-17-92 expression in lymphocytes Academic Article
- Macrophages kill capillary cells in G1 phase of the cell cycle during programmed vascular regression Academic Article
- Mammalian polymerase theta promotes alternative NHEJ and suppresses recombination Academic Article
- Mathematical modeling supports substantial mouse neural progenitor cell death Academic Article
- Mdm4 (mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development Academic Article
- Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection Academic Article
- Mechanism of cell death caused by complex i defects in a rat dopaminergic cell line Academic Article
- Mechanism of toxicity in rotenone models of parkinson's disease Academic Article
- Mechanism of toxicity of pesticides acting at complex i: Relevance to environmental etiologies of parkinson's disease Academic Article
- Mechanisms of sodium nitroprusside-induced death in human chondrocytes Academic Article
- Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition Academic Article
- Metaxin is required for tumor necrosis factor-induced cell death Academic Article
- Methamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus Academic Article
- Mir-150 controls b cell differentiation by targeting the transcription factor c-myb Academic Article
- Misexpression of the eyes absent family triggers the apoptotic program Academic Article
- Mitochondrial dynamics in cell death and neurodegeneration Academic Article
- Mitochondrial fission is an upstream and required event for Bax foci formation in response to nitric oxide in cortical neurons Academic Article
- Molecular basis of glutamate toxicity in retinal ganglion cells Academic Article
- Molecular mechanisms of nitrosative stress-mediated protein misfolding in neurodegenerative diseases Academic Article
- Molecular medicine and neurodegenerative diseases Academic Article
- Myocyte protection by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of the Ras GTP-ase pathway Academic Article
- Naturally death-resistant precursor cells revealed as the origin of retinoblastoma Academic Article
- Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice Academic Article
- Neurogenesis and commitment of corticospinal neurons in reeler Academic Article
- Neuronal death induced by misfolded prion protein is due to NAD(+) depletion and can be relieved in vitro and in vivo by NAD(+) replenishment Academic Article
- Neuronal protection and destruction by NO Academic Article
- Neuroprotection by the NR3A subunit of the NMDA receptor Academic Article
- No immune responses by the expression of the yeast ndi1 protein in rats Academic Article
- Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding Academic Article
- Obligatory role for complex i inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) Academic Article
- Osteopontin expression in the brain triggers localized inflammation and cell death when immune cells are activated by pertussis toxin Academic Article
- Paradigm shift in NMDA receptor antagonist drug development: Molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders Academic Article
- Peptidylariginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates Academic Article
- Perception of brassinosteroids by the extracellular domain of the receptor kinase BRI1 Academic Article
- Periadolescent ethanol vapor exposure persistently reduces measures of hippocampal neurogenesis that are associated with behavioral outcomes in adulthood Academic Article
- Peripheral deletion of self-reactive b-cells Academic Article
- Pharmacokinetics and efficacy of the spleen tyrosine kinase inhibitor r406 after ocular delivery for retinoblastoma Academic Article
- Precursor thymocyte proliferation and differentiation are controlled by signals unrelated to the pre-TCR Academic Article
- Prolonged waking reduces human immunodeficiency virus glycoprotein 120- or tumor necrosis factor alpha-induced apoptosis in the cerebral cortex of rats Academic Article
- Protective effects of 6-ureido/thioureido-2,4,5-trimethylpyridin-3-ols against 4-hydroxynonenal-induced cell death in adult retinal pigment epithelial-19 cells Academic Article
- Protective effects of heme oxygenase-1 against mpp(+)-induced cytotoxicity in pc-12 cells Academic Article
- RIG-I enhanced interferon independent apoptosis upon Junin virus infection Academic Article
- Ratio of S-nitrosohomocyst(e)ine to homocyst(e)ine or other thiols determines neurotoxicity in rat cerebrocortical cultures Academic Article
- Rearranging views on neurogenesis: Neuronal death in the absence of DNA end-joining proteins Academic Article
- Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases Academic Article
- Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases Academic Article
- Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress Academic Article
- Responses of microRNAs 124a and 223 following spinal cord injury in mice Academic Article
- Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity Academic Article
- Ricin cytotoxicity is sensitive to recycling between the endoplasmic-reticulum and the Golgi-complex Academic Article
- Role of transient receptor potential channel 1 (TRPC1) in glutamate-induced cell death in the hippocampal cell line HT22 Academic Article
- S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease Academic Article
- Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival Academic Article
- Selective inhibition of mitochondrial jnk signaling achieved using peptide mimicry of the sab kinase interacting motif-1 (kim1) Academic Article
- Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha Academic Article
- Sensory neuronal phenotype in galanin receptor 2 knockout mice: Focus on dorsal root ganglion neurone development and pain behaviour Academic Article
- Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in Fragile X-associated tremor/ataxia syndrome Academic Article
- Serum- and glucocorticoid-inducible kinase 1 confers protection in cell-based and in in vivo neurotoxin models via the c-Jun N-terminal kinase signaling pathway Academic Article
- Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer Academic Article
- Signaling t-cell survival and death by il-2 and il-15 Academic Article
- Signalling for survival and death in neurones - the role of stress-activated kinases, jnk and p38 Academic Article
- Similarity of neuronal cell injury and death in AIDS dementia and focal cerebral ischemia: Potential treatment with NMDA open-channel blockers and nitric oxide-related species Academic Article
- Simultaneous intracellular calcium and sodium flux imaging in human vanilloid receptor 1 (VR1)-transfected human embryonic kidney cells: A method to resolve ionic dependence of VR1-mediated cell death Academic Article
- Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus Academic Article
- Structure activity studies of a novel cytotoxic benzodiazepine Academic Article
- Sulfuretin inhibits 6-hydroxydopamine-induced neuronal cell death via reactive oxygen species-dependent mechanisms in human neuroblastoma SH-SY5Y cells Academic Article
- Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models Academic Article
- Suppression of c-myc expression and c-myc function in response to sustained DNA damage in mcf-7 breast tumor cells Academic Article
- Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor Academic Article
- Synthesis of key sandramycin analogs: Systematic examination of the intercalation chromophore Academic Article
- TNFR1/phox interaction and TNFR1 mitochondrial translocation Thwart silica-induced pulmonary fibrosis Academic Article
- Targeted disruption of the Artemis murine counterpart results in SCID and defective V(D)J recombination that is partially corrected with bone marrow transplantation Academic Article
- The activity-dependent histone variant H2BE modulates the life span of olfactory neurons Academic Article
- The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-beta-mediated antiviral activity in vitro and in vivo Academic Article
- The anticancer ruthenium complex KP1019 induces DNA damage, leading to cell cycle delay and cell death in Saccharomyces cerevisiae Academic Article
- The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death Academic Article
- The autoimmunity-inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular and antigenic properties Academic Article
- The c-jun-n-terminal kinase is involved in the neurotoxic effect of azaspiracid-1 Academic Article
- The contribution of various NOS gene products to HIV-1 coat protein (gp120)-mediated retinal ganglion cell injury Academic Article
- The df-1 chicken fibroblast cell line: Transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses Academic Article
- The effect of glycosaminoglycan loss on chondrocyte viability: a study on porcine cartilage explants Academic Article
- The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity Academic Article
- The polyamine oxidase inhibitor mdl-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects Academic Article
- The temporal expression patterns of fibronectin and its receptors-α5β1 and αvβ3 integrins on blood vessels after cerebral ischemia Academic Article
- Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival Academic Article
- Tid1 is required for T cell transition from double-negative 3 to double-positive stages Academic Article
- Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons Academic Article
- Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death Academic Article
- Transforming growth factor-beta 1 increases survival of human melanoma through stroma remodeling Academic Article
- Upregulation of fibronectin and the α5β1 and αvβ3 integrins on blood vessels within the cerebral ischemic penumbra Academic Article
- Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis Academic Article
- Viral rna induces type i interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5 implications for viral infection-associated glomerulonephritis Academic Article
- [HIV glycoprotein 120: possible etiological agent of AIDS-associated dementia] [Article in Spanish] Academic Article