subject area of

• 2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies  Academic Article
• A blueprint for HIV vaccine discovery  Academic Article
• A candidate live inactivatable attenuated vaccine for aids  Academic Article
• A comparative immunogenicity study of hiv-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120  Academic Article
• A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals  Academic Article
• A live-virus ''suicide'' vaccine for human immunodeficiency virus  Academic Article
• A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene  Academic Article
• A next-generation cleaved, soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies  Academic Article
• A structure-based approach to a synthetic vaccine for hiv-1  Academic Article
• A vaccine for hiv type 1: The antibody perspective  Academic Article
• AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges  Academic Article
• An engineered mutant of hiv-1 gp120 formulated with adjuvant quil a promotes elicitation of antibody responses overlapping the cd4-binding site  Academic Article
• Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis b surface antigen particles  Academic Article
• Another HIV vaccine failure: where to next?  Academic Article
• Anti-HIV B Cell lines as candidate vaccine biosensors  Academic Article
• Anti-human immunodeficiency virus type 1 (hiv-1) antibodies 2f5 and 4e10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize hiv-1  Academic Article
• Antibody 2g12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the hiv-1 glycan shield if domain exchanged  Academic Article
• Antibody neutralization of hiv-1 and the potential for vaccine design  Academic Article
• Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design  Academic Article
• Antibody responses to envelope glycoproteins in HIV-1 infection  Academic Article
• Antibody vs. HIV in a clash of evolutionary titans  Academic Article
• Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy  Academic Article
• B cell liaison confounds HIV-1 evolution  Academic Article
• B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates  Academic Article
• Biochemical and immunogenic characterization of soluble human immunodeficiency virus type 1 envelope glycoprotein trimers expressed by semliki forest virus  Academic Article
• Blys-mediated modulation of naive b cell subsets impacts hiv env-induced antibody responses  Academic Article
• Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface  Academic Article
• Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target  Academic Article
• Broad neutralization coverage of HIV by multiple highly potent antibodies  Academic Article
• Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses  Academic Article
• Broadly neutralizing antibody responses in a large longitudinal Sub-Saharan HIV primary infection cohort  Academic Article
• Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers  Academic Article
• CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies  Academic Article
• Challenges for structure-based HIV vaccine design  Academic Article
• Characterization of human immunodeficiency virus type 1 (HIV-1) Gag- and Gag peptide-specific CD4(+) T-cell clones from an HIV-1-seronegative donor following in vitro immunization  Academic Article
• Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation  Academic Article
• Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design  Academic Article
• Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus  Academic Article
• Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies  Academic Article
• Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic hiv vaccine epitope  Academic Article
• Computational protein design using flexible backbone remodeling and resurfacing: case studies in structure-based antigen design  Academic Article
• Covalent linkage of HIV-1 trimers to synthetic liposomes elicits improved B cell and antibody responses  Academic Article
• Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer  Academic Article
• Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design  Academic Article
• Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design  Academic Article
• Cta1-dd adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization  Academic Article
• Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds  Academic Article
• Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant  Academic Article
• Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies  Academic Article
• Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity  Academic Article
• Dissection of the carbohydrate specificity of the broadly neutralizing-anti-hiv-1 antibody 2g12  Academic Article
• Diverse antibody genetic and recognition properties revealed following HIV-1 envelope glycoprotein immunization  Academic Article
• Effects of antigen and genetic adjuvants on immune responses to human immunodeficiency virus DNA vaccines in mice  Academic Article
• Efficient neutralization of primary isolates of hiv-1 by a recombinant human monoclonal-antibody  Academic Article
• Elicitation of simian immunodeficiency virus-specific cytotoxic t lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination  Academic Article
• Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies  Academic Article
• Enhanced mucosal immunoglobulin a response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system  Academic Article
• Estimating the respective contributions of human and viral genetic variation to HIV control  Academic Article
• Evaluation of gp160 vaccinees in the hu-PBL-SCID mouse model  Academic Article
• Expanded breadth of virus neutralization after immunization with a multiclade envelope hiv vaccine candidate  Academic Article
• Factors limiting the immunogenicity of hiv-1 gp120 envelope glycoproteins  Academic Article
• Fc receptor but not complement binding is important in antibody protection against HIV  Academic Article
• Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing  Academic Article
• Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody  Academic Article
• Genetic subtypes, humoral immunity, and human immunodeficiency virus type 1 vaccine development  Academic Article
• Genomics meets HIV-1  Academic Article
• Gp120: Biologic aspects of structural features  Academic Article
• HIV envelope glycoform heterogeneity and localized diversity govern the initiation and maturation of a V2 apex broadly neutralizing antibody lineage  Academic Article
• HIV vaccine design: Insights from live attenuated siv vaccines  Academic Article
• HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogene  Academic Article
• HIV-1 envelope evolution and vaccine efficacy  Academic Article
• HIV-1 neutralizing antibodies induced by native-like envelope trimers  Academic Article
• HIV-1 neutralizing antibodies induced by native-like envelope trimers  Academic Article
• Heterologous envelope immunogens contribute to aids vaccine protection in rhesus monkeys  Academic Article
• High-resolution definition of vaccine-elicited b cell responses against the hiv primary receptor binding site  Academic Article
• High-throughput protein engineering improves the antigenicity and stability of soluble HIV-1 envelope glycoprotein SOSIP trimers  Academic Article
• Hiv-1 and influenza antibodies: Seeing antigens in new ways  Academic Article
• Hiv-1 env(gp140) trimers elicit neutralizing antibodies without efficient induction of conformational antibodies  Academic Article
• Hiv-1 neutralization: Mechanisms and relevance to vaccine design  Academic Article
• Human immunodeficiency virus type 1 env trimer immunization of macaques and impact of priming with viral vector or stabilized core protein  Academic Article
• Hyperglycosylated mutants of human immunodeficiency virus (hiv) type 1 monomeric gp120 as novel antigens for hiv vaccine design  Academic Article
• Immune Focusing and Enhanced Neutralization Induced by HIV-1 gp140 Chemical Cross-Linking  Academic Article
• Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10  Academic Article
• Immunization with recombinant hla classes i and ii, hiv-1 gp140, and siv p27 elicits protection against heterologous shiv infection in rhesus macaques  Academic Article
• Immunization with wild-type or cd4-binding-defective hiv-1 env trimers reduces viremia equivalently following heterologous challenge with simian-human immunodeficiency virus  Academic Article
• Immunogenic display of purified chemically cross-linked HIV-1 spikes  Academic Article
• Immunogenicity of DNA vaccines expressing human immunodeficiency virus type 1 envelope glycoprotein with and without deletions in the v1/2 and v3 regions  Academic Article
• Immunogenicity of multiple gene and clade human immunodeficiency virus type 1 DNA vaccines  Academic Article
• Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing epitopes  Academic Article
• In vitro antigen challenge of human antibody libraries for vaccine evaluation: The human immunodeficiency virus type 1 envelope  Academic Article
• In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1  Academic Article
• Increased hiv-1 vaccine efficacy against viruses with genetic signatures in env v2  Academic Article
• Independent expansion of epitope-specific plasma cell responses upon HIV-1 envelope glycoprotein immunization  Academic Article
• Influence of novel cd4 binding-defective hiv-1 envelope glycoprotein immunogens on neutralizing antibody and t-cell responses in nonhuman primates  Academic Article
• Inhibition of hiv-1 entry by antibodies: Potential viral and cellular targets  Academic Article
• Lessons from the cat: Feline immunodeficiency virus as a tool to develop intervention strategies against human immunodeficiency virus type 1  Academic Article
• Limited or no protection by weakly or nonneutralizing antibodies against vaginal shiv challenge of macaques compared with a strongly neutralizing antibody  Academic Article
• Maturation pathway from germline to broad HIV-1 neutralizer of a CD4-mimic antibody  Academic Article
• Modifications of the human immunodeficiency virus envelope glycoprotein enhance immunogenicity for genetic immunization  Academic Article
• Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies  Academic Article
• Multiclade human immunodeficiency virus type 1 envelope immunogens elicit broad cellular and humoral immunity in rhesus monkeys  Academic Article
• Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies  Academic Article
• Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins  Academic Article
• Neutralizing antibodies generated during natural hiv-1 infection: Good news for an hiv-1 vaccine?  Academic Article
• Nonhuman primate models and the failure of the merck hiv-1 vaccine in humans  Academic Article
• Nonneutralizing antibodies to the cd4-binding site on the gp120 subunit of human immunodeficiency virus type 1 do not interfere with the activity of a neutralizing antibody against the same site  Academic Article
• Phase 1 safety and immunogenicity evaluation of a multiclade hiv-1 DNA candidate vaccine  Academic Article
• Phase 1 safety and immunogenicity evaluation of a multiclade hiv-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector  Academic Article
• Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines  Academic Article
• Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity  Academic Article
• Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate  Academic Article
• Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice  Academic Article
• Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen  Academic Article
• Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV  Academic Article
• Rational HIV immunogen design to target specific germline B cell receptors  Academic Article
• Rational antibody-based HIV-1 vaccine design: current approaches and future directions  Academic Article
• Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to hiv-1  Academic Article
• Rational modifications of hiv-1 envelope glycoproteins for immunogen design  Academic Article
• Recent advances in carbohydrate-based vaccines  Academic Article
• Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs.  Academic Article
• Reducing V3 antigenicity and immunogenicity on soluble, native-like HIV-1 Env SOSIP trimers  Academic Article
• Relationship between antibody 2f5 neutralization of hiv-1 and hydrophobicity of its heavy chain third complementarity-determining region  Academic Article
• Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design  Academic Article
• Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates  Academic Article
• Resistance to human immunodeficiency virus 1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinia gp160 and recombinant gp160  Academic Article
• Rhesus macaque B-cell responses to an HIV-1 trimer vaccine revealed by unbiased longitudinal repertoire analysis  Academic Article
• Selective expansion of hiv-1 envelope glycoprotein-specific b cell subsets recognizing distinct structural elements following immunization  Academic Article
• Solution conformation of an immunogenic peptide derived from the principal neutralizing determinant of the HIV-2 envelope glycoprotein gp125  Academic Article
• Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein  Academic Article
• Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins  Academic Article
• Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01  Academic Article
• Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers  Academic Article
• Structural evolution of glycan recognition by a family of potent HIV antibodies  Academic Article
• Structural insights into key sites of vulnerability on hiv-1 env and influenza ha  Academic Article
• Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence  Academic Article
• Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9  Academic Article
• Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site  Academic Article
• Structure-based stabilization of hiv-1 gp120 enhances humoral immune responses to the induced co-receptor binding site  Academic Article
• Structure-based vaccine design in hiv: Blind men and the elephant?  Academic Article
• Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies  Academic Article
• Targeting HIV-1 gp41 in close proximity to the membrane using antibody and other molecules  Academic Article
• The challenges of eliciting neutralizing antibodies to hiv-1 and to influenza virus  Academic Article
• The development of cowpea mosaic virus as a potential source of novel vaccines  Academic Article
• The hiv-1 envelope glycoproteins: Fusogens, antigens, and immunogens  Academic Article
• The membrane-proximal external region of hiv-1 gp41: A vaccine target worth exploring  Academic Article
• The neutralizing antibody response to hiv-1: Viral evasion and escape from humoral immunity  Academic Article
• Toward an aids vaccine  Academic Article
• Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures  Academic Article
• VRX-496(VIRxSYS)  Academic Article
• Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign  Academic Article
• Vaccine-elicited tier 2 HIV-1 neutralizing antibodies bind to quaternary epitopes involving glycan-deficient patches proximal to the CD4 binding site  Academic Article
• Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties  Academic Article