subject area of

• A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response  Academic Article
• Activation of Rac-1 Rac-2, and Cdc42 by hemopoietic growth factors or cross-linking of the B-lymphocyte receptor for antigen  Academic Article
• Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth  Academic Article
• Amplification, rearrangement, and elevated expression of c-myc in the human prostatic carcinoma cell line LNCaP  Academic Article
• Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis  Academic Article
• Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer  Academic Article
• Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis  Academic Article
• Design and discovery of N-(2-Methyl-5 '-morpholino-6 '-((tetrahydro-2H-pyran-4-yl)oxy)- 3,3 '-bipyridin -5-yl)-3-(trifluoromethyl)benzamide (RAF709): a potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers  Academic Article
• Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation  Academic Article
• Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway  Academic Article
• High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling  Academic Article
• Induction of the early growth response (Egr) family of transcription factors during thymic selection  Academic Article
• Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models  Academic Article
• Leucine-rich repeats and carboxyl terminus are required for interaction of yeast adenylate cyclase with RAS proteins  Academic Article
• Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention  Academic Article
• Monocyte deactivation by interleukin-10 via inhibition of tyrosine kinase-activity and the Ras signaling pathway  Academic Article
• Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53  Academic Article
• Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function  Academic Article
• Oncogenic KRAS confers chemoresistance by upregulating NRF2  Academic Article
• Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis  Academic Article
• Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism  Academic Article
• Polylysine domain of K-ras 4B protein is crucial for malignant transformation  Academic Article
• Probing the role of loop 2 in Ras function with unnatural amino acids  Academic Article
• Probing the structure and mechanism of Ras protein with an expanded genetic code  Academic Article
• Several gtp-binding proteins, including p21c-h-ras, are preferred substrates of pseudomonas-aeruginosa exoenzyme-s  Academic Article
• Synthetic peptides of the rab effector domain inhibit vesicular transport through the secretory pathway  Academic Article