subject area of
- A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response Academic Article
- Activation of Rac-1 Rac-2, and Cdc42 by hemopoietic growth factors or cross-linking of the B-lymphocyte receptor for antigen Academic Article
- Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth Academic Article
- Amplification, rearrangement, and elevated expression of c-myc in the human prostatic carcinoma cell line LNCaP Academic Article
- Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis Academic Article
- Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer Academic Article
- Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis Academic Article
- Design and discovery of N-(2-Methyl-5 '-morpholino-6 '-((tetrahydro-2H-pyran-4-yl)oxy)- 3,3 '-bipyridin -5-yl)-3-(trifluoromethyl)benzamide (RAF709): a potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers Academic Article
- Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation Academic Article
- Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway Academic Article
- High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling Academic Article
- Induction of the early growth response (Egr) family of transcription factors during thymic selection Academic Article
- Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models Academic Article
- Leucine-rich repeats and carboxyl terminus are required for interaction of yeast adenylate cyclase with RAS proteins Academic Article
- Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention Academic Article
- Monocyte deactivation by interleukin-10 via inhibition of tyrosine kinase-activity and the Ras signaling pathway Academic Article
- Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53 Academic Article
- Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function Academic Article
- Oncogenic KRAS confers chemoresistance by upregulating NRF2 Academic Article
- Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis Academic Article
- Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism Academic Article
- Polylysine domain of K-ras 4B protein is crucial for malignant transformation Academic Article
- Probing the role of loop 2 in Ras function with unnatural amino acids Academic Article
- Probing the structure and mechanism of Ras protein with an expanded genetic code Academic Article
- Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries Academic Article
- Several gtp-binding proteins, including p21c-h-ras, are preferred substrates of pseudomonas-aeruginosa exoenzyme-s Academic Article
- Synthetic peptides of the rab effector domain inhibit vesicular transport through the secretory pathway Academic Article