subject area of

• 2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies  Academic Article
• A binary plasmid system for shuffling combinatorial antibody libraries  Academic Article
• A biosensor-based approach toward purification and crystallization of g protein-coupled receptors  Academic Article
• A chimeric hiv-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (gm-csf) domain induces enhanced antibody and t cell responses  Academic Article
• A comparative immunogenicity study of hiv-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120  Academic Article
• A conserved hiv gp120 glycoprotein structure involved in chemokine receptor binding  Academic Article
• A directed molecular evolution approach to improved immunogenicity of the hiv-1 envelope glycoprotein  Academic Article
• A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120  Academic Article
• A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly  Academic Article
• A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2g12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120  Academic Article
• A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs  Academic Article
• A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1  Academic Article
• A large array of human monoclonal-antibodies to type-1 human-immunodeficiency-virus from combinatorial libraries of asymptomatic seropositive individuals  Academic Article
• A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals  Academic Article
• A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41  Academic Article
• A new perspective on V3 phenotype prediction  Academic Article
• A nonself sugar mimic of the hiv glycan shield shows enhanced antigenicity  Academic Article
• A novel human antibody against human immunodeficiency virus type 1 gp120 is v1, v2, and v3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin g1 b12  Academic Article
• A novel strategy for efficient production of anti-V3 human scFvs against HIV-1 clade C  Academic Article
• A peptide inhibitor of hiv-1 neutralizing antibody 2g12 is not a structural mimic of the natural carbohydrate epitope on gp120  Academic Article
• A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield  Academic Article
• A short segment of the hiv-1 gp120 v1/v2 region is a major determinant of resistance to v1/v2 neutralizing antibodies  Academic Article
• A structure-based approach to a synthetic vaccine for hiv-1  Academic Article
• A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5  Academic Article
• A tyrosine-sulfated CCR5-mimetic peptide promotes conformational transitions in the HIV-1 envelope glycoprotein  Academic Article
• A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry  Academic Article
• A tyrosine-sulfated peptide derived from the heavy-chain CDR3 region of an HIV-1-neutralizing antibody binds gp120 and inhibits HIV-1 infection  Academic Article
• AIDS-related dementia and calcium homeostasis  Academic Article
• Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gpl120 is sterically restricted on primary human immunodeficiency virus type 1  Academic Article
• Adaptation of a CCR5-using, primary human immunodeficiency virus type 1 isolate for CD4-independent replication  Academic Article
• Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid)  Academic Article
• Alteration of methamphetamine-induced stereotypic behaviour in transgenic mice expressing hiv-1 envelope protein gp120  Academic Article
• An antibody-recruiting small molecule that targets HIV gp120  Academic Article
• An aptamer that neutralizes r5 strains of hiv-1 binds to core residues of gp120 in the ccr5 binding site  Academic Article
• An aptamer that neutralizes r5 strains of human immunodeficiency virus type 1 blocks gp120-ccr5 interaction  Academic Article
• An engineered mutant of hiv-1 gp120 formulated with adjuvant quil a promotes elicitation of antibody responses overlapping the cd4-binding site  Academic Article
• Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors  Academic Article
• Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals  Academic Article
• Analysis of the interaction of antibodies with a conserved, enzymatically deglycosylated core of the hiv type 1 envelope glycoprotein 120  Academic Article
• Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein  Academic Article
• Analysis of the neutralization breadth of the anti-v3 antibody f425-b4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis  Academic Article
• Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins  Academic Article
• Antibodies against hiv-1 from phage display libraries: Mapping of an immune response and progress towards antiviral immunotherapy  Academic Article
• Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike  Academic Article
• Antibody 17b binding at the coreceptor site weakens the kinetics of the interaction of envelope glycoprotein gp120 with cd4  Academic Article
• Antibody 2g12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the hiv-1 glycan shield if domain exchanged  Academic Article
• Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike  Academic Article
• Antibody domain exchange is an immunological solution to carbohydrate cluster recognition  Academic Article
• Antibody neutralization of hiv-1 and the potential for vaccine design  Academic Article
• Antibody neutralization-resistant primary isolates of human immunodeficiency virus type 1  Academic Article
• Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design  Academic Article
• Antibody vs. HIV in a clash of evolutionary titans  Academic Article
• Antigen selection from an HIV-1 immune antibody library displayed on yeast yields many novel antibodies compared to selection from the same library displayed on phage  Academic Article
• Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy  Academic Article
• Antigenic mimicry of the hiv envelope by aids-associated pathogens  Academic Article
• Antigenic peptides  Academic Article
• Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificities  Academic Article
• B cell recognition of the conserved hiv-1 co-receptor binding site is altered by endogenous primate cd4  Academic Article
• B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates  Academic Article
• Binding antibody responses to the immunogenic regions of viral envelope in HIV-1-infected Indian children  Academic Article
• Biochemically defined hiv-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the cd4-binding site  Academic Article
• Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface  Academic Article
• Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target  Academic Article
• Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals  Academic Article
• Broadly cross-reactive hiv-1-neutralizing human monoclonal fab selected for binding to gp120-cd4-ccr5 complexes  Academic Article
• Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers  Academic Article
• Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans  Academic Article
• CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120  Academic Article
• CD4-independent binding of SIV gp120 to rhesus CCR5  Academic Article
• CD4-induced T-20 binding to human immunodeficiency virus type 1 gp120 blocks interaction with the CXCR4 coreceptor  Academic Article
• CD4-induced activation in a soluble HIV-1 Env trimer  Academic Article
• CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5  Academic Article
• CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies  Academic Article
• Calcium channel antagonists and human immunodeficiency virus coat protein-mediated neuronal injury  Academic Article
• Caspase cascades in human immunodeficiency virus-associated neurodegeneration  Academic Article
• Cdr walking mutagenesis for the affinity maturation of a potent human anti-hiv-1 antibody into the picomolar range  Academic Article
• Cell-free human immunodeficiency virus type 1 transcytosis through primary genital epithelial cells  Academic Article
• Changes in the V3 region of gp 120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta 32 heterozygote  Academic Article
• Characterization by serial deletion competition elisas of hiv-1 v3 loop epitopes recognized by monoclonal antibodies  Academic Article
• Characterization of antibody responses elicited by human immunodeficiency virus type 1 primary isolate trimeric and monomeric envelope glycoproteins in selected adjuvants  Academic Article
• Characterization of antibody responses to purified hiv-1 gp120 glycoproteins fused with the molecular adjuvant c3d  Academic Article
• Characterization of human immunodeficiency virus type 1 monomeric and trimeric gp120 glycoproteins stabilized in the cd4-bound state: Antigenicity, biophysics, and immunogenicity  Academic Article
• Characterization of primary isolate-like variants of simian-human immunodeficiency virus  Academic Article
• Characterization of stable, soluble trimers containing complete ectodomains of human immunodeficiency virus type 1 envelope glycoproteins  Academic Article
• Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants  Academic Article
• Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis  Academic Article
• Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus  Academic Article
• Combination of methamphetamine and HIV-1 gp120 causes distinct long-term alterations of behavior, gene expression, and injury in the central nervous system  Academic Article
• Comparing antigenicity and immunogenicity of engineered gp120  Academic Article
• Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer  Academic Article
• Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies  Academic Article
• Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold  Academic Article
• Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding  Academic Article
• Conformational changes of gp120 in epitopes near the ccr5 binding site are induced by cd4 and a cd4 miniprotein mimetic  Academic Article
• Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions  Academic Article
• Contribution of charged amino acids in the CDR2 region of CD4 to HIV-1 gp120 binding  Academic Article
• Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG  Academic Article
• Cross-neutralizing activity of human anti-V3 monoclonal antibodies derived from non-B clade HIV-1 infected individuals  Academic Article
• Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer  Academic Article
• Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262  Academic Article
• Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design  Academic Article
• Crystal structure of a soluble cleaved HIV-1 envelope trimer  Academic Article
• Crystal structure of the broadly cross-reactive hiv-1-neutralizing fab x5 and fine mapping of its epitope  Academic Article
• Crystal structures of human immunodeficiency virus type 1 (hiv-1) neutralizing antibody 2219 in complex with three different v3 peptides reveal a new binding mode for hiv-1 cross-reactivity  Academic Article
• Crystal-structure of a human-immunodeficiency-virus type-1 neutralizing antibody, 50.1, in complex with its v3 loop peptide antigen  Academic Article
• Crystal-structure of the principal neutralization site of hiv-1  Academic Article
• Crystallization, sequence, and preliminary crystallographic data for an antipeptide-fab-50.1 and peptide complexes with the principal neutralizing determinant of hiv-1 gp120  Academic Article
• Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of L-cysteine  Academic Article
• Dementia associated with the acquired immunodeficiency syndrome  Academic Article
• Design and characterization of stabilized derivatives of human cd4d12 and cd4d1  Academic Article
• Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble cd4 and monoclonal antibodies  Academic Article
• Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits  Academic Article
• Differential effects of pharmacologic and genetic modulation of NMDA receptor activity on HIV/gp120-induced neuronal damage in an in vivo mouse model  Academic Article
• Direct antibody access to the HIV-1 membrane-proximal external region positively correlates with neutralization sensitivity  Academic Article
• Dissection of the carbohydrate specificity of the broadly neutralizing-anti-hiv-1 antibody 2g12  Academic Article
• Diverse antibody genetic and recognition properties revealed following HIV-1 envelope glycoprotein immunization  Academic Article
• Drift of the HIV-1 envelope glycoprotein gp120 toward increased neutralization resistance over the course of the epidemic: a comprehensive study using the most potent and broadly neutralizing monoclonal antibodies  Academic Article
• Dual conformations for the hiv-1 gp120 v3 loop in complexes with different neutralizing fabs  Academic Article
• Dual specificity of a human neutralizing monoclonal antibody, specific for the v3 loop of gp120 (hiv-1)  Academic Article
• Effect of polyanion-resistance on HIV-1 infection  Academic Article
• Efficient neutralization of primary isolates of hiv-1 by a recombinant human monoclonal-antibody  Academic Article
• Efficient recovery of high-affinity antibodies from a single-chain fab yeast display library  Academic Article
• Energetics of the hiv gp120-cd4 binding reaction  Academic Article
• Enhanced exposure of the cd4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain  Academic Article
• Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor  Academic Article
• Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins  Academic Article
• Envelope diversity, characteristics of V3 region and predicted co-receptor usage of human immunodeficiency viruses infecting north Indians  Academic Article
• Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens  Academic Article
• Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders  Academic Article
• Erythropoietin protects cerebrocortical neurons from HIV-1/gp120-induced damage  Academic Article
• Factors limiting the immunogenicity of hiv-1 gp120 envelope glycoproteins  Academic Article
• Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120  Academic Article
• Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region  Academic Article
• Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing  Academic Article
• Functional and immunological characterization of human-immunodeficiency-virus type-1 envelope glycoproteins containing deletions of the major variable regions  Academic Article
• Functional mimicry of a human immunodeficiency virus type 1 coreceptor by a neutralizing monoclonal antibody  Academic Article
• Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex  Academic Article
• Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1)  Academic Article
• Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody  Academic Article
• Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule ccr5 inhibitor  Academic Article
• Genetic composition of human immunodeficiency virus type 1 in cerebrospinal fluid and blood without treatment and during failing antiretroviral therapy  Academic Article
• Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies  Academic Article
• Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation  Academic Article
• Gp120: Biologic aspects of structural features  Academic Article
• HIV displays its coat of arms  Academic Article
• HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists  Academic Article
• HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection  Academic Article
• HIV-1 envelope evolution and vaccine efficacy  Academic Article
• HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites  Academic Article
• HIV-1 infection and AIDS: consequences for the central nervous system  Academic Article
• HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entry  Academic Article
• HIV-related neuronal injury. Potential therapeutic intervention with calcium channel antagonists and NMDA antagonists  Academic Article
• HIV-related neurotoxicity  Academic Article
• HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest  Academic Article
• Heterogeneity of envelope molecules expressed on primary human immunodeficiency virus type 1 particles as probed by the binding of neutralizing and nonneutralizing antibodies  Academic Article
• High-resolution definition of vaccine-elicited b cell responses against the hiv primary receptor binding site  Academic Article
• Highly efficient neutralization by plasma antibodies from human immunodeficiency virus type-1 infected individuals on antiretroviral drug therapy  Academic Article
• Highly stable trimers formed by human immunodeficiency virus type 1 envelope glycoproteins fused with the trimeric motif of T4 bacteriophage fibritin  Academic Article
• Hiv type 1 env precursor cleavage state affects recognition by both neutralizing and nonneutralizing gp41 antibodies  Academic Article
• Hiv- and fiv-derived gp120 alter spatial memory, ltp, and sleep in rats  Academic Article
• Hiv-1 neutralization: Mechanisms and relevance to vaccine design  Academic Article
• Hiv-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins  Academic Article
• Hiv-derived protein gp120 suppresses p3 potential in rats: Potential implications in hiv-associated dementia  Academic Article
• Host cyclophilin A mediates HIV-1 attachment to target cells via heparans  Academic Article
• Human immunodeficiency virus envelope (gp120) binding to dc-sign and primary dendritic cells is carbohydrate dependent but does not involve 2g12 or cyanovirin binding sites: Implications for structural analyses of gp120-dc-sign binding  Academic Article
• Human immunodeficiency virus type 1 coreceptor switching: V1/V2 gain-of-fitness mutations compensate for V3 loss-of-fitness mutations  Academic Article
• Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody igg1b12  Academic Article
• Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons  Academic Article
• Human immunodeficiency virus-infected macrophages, gp120, and N-methyl-D-aspartate receptor-mediated neurotoxicity  Academic Article
• Human monoclonal antibodies: Recent achievements  Academic Article
• Human plasmacytoid dendritic cells efficiently capture HIV-1 envelope glycoproteins via CD4 for antigen presentation  Academic Article
• Human-antibodies to hiv-1 by recombinant-DNA methods  Academic Article
• Human-immunodeficiency-virus infection of human brain capillary endothelial-cells occurs via a cd4 galactosylceramide-independent mechanism  Academic Article
• Hyperglycosylated mutants of human immunodeficiency virus (hiv) type 1 monomeric gp120 as novel antigens for hiv vaccine design  Academic Article
• Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies  Academic Article
• Iap suppression of apoptosis involves distinct mechanisms: The tak1/jnk1 signaling cascade and caspase inhibition  Academic Article
• Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody  Academic Article
• Identification of an HIV-1 clade A envelope that exhibits broad antigenicity and neutralization sensitivity and elicits antibodies targeting three distinct epitopes  Academic Article
• Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10  Academic Article
• Immunofocusing: Antigen engineering to promote the induction of hiv-neutralizing antibodies  Academic Article
• Immunogenicity of DNA vaccines expressing human immunodeficiency virus type 1 envelope glycoprotein with and without deletions in the v1/2 and v3 regions  Academic Article
• Improved breadth and potency of an hiv-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning  Academic Article
• Improved design of an antigen with enhanced specificity for the broadly hiv-neutralizing antibody b12  Academic Article
• Improved elicitation of neutralizing antibodies against primary human immunodeficiency viruses by soluble stabilized envelope glycoprotein trimers  Academic Article
• In vitro antigen challenge of human antibody libraries for vaccine evaluation: The human immunodeficiency virus type 1 envelope  Academic Article
• In-vitro evolution of a neutralizing human-antibody to human-immunodeficiency-virus type-1 to enhance affinity and broaden strain cross-reactivity  Academic Article
• Increased functional stability and homogeneity of viral envelope spikes through directed evolution  Academic Article
• Independent expansion of epitope-specific plasma cell responses upon HIV-1 envelope glycoprotein immunization  Academic Article
• Influence of novel cd4 binding-defective hiv-1 envelope glycoprotein immunogens on neutralizing antibody and t-cell responses in nonhuman primates  Academic Article
• Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein  Academic Article
• Inhibition of HIV ENV binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120  Academic Article
• Inhibition of hiv-1 infectivity and epithelial cell transfer by human monoclonal igg and iga antibodies carrying the b12 v region  Academic Article
• Inhibition of the ERK pathway prevents HIVgp120-induced REM sleep increase  Academic Article
• Inhibition of virus attachment to cd4(+) target cells is a major mechanism of t cell line-adapted hiv-1 neutralization  Academic Article
• Interactions among hiv gp120, cd4, and cxcr4: Dependence on cd4 expression level, gp120 viral origin, conservation of the gp120 cooh- and nh(2)-termini and v1/v2 and v3 loops, and sensitivity to neutralizing antibodies  Academic Article
• Interferon-independent, human immunodeficiency virus type 1 gp120-mediated induction of cxcl10/ip-10 gene expression by astrocytes in vivo and in vitro  Academic Article
• Intrinsic obstacles to human immunodeficiency virus type 1 coreceptor switching  Academic Article
• Involvement of the v1/v2 variable loop structure in the exposure of human-immunodeficiency-virus type-1 gp120 epitopes induced by receptor-binding  Academic Article
• Isobaric tagging-based quantification by mass spectrometry of differentially regulated proteins in synaptosomes of HIV/gp120 transgenic mice: implications for HIV-associated neurodegeneration  Academic Article
• Key gp120 glycans pose roadblocks to the rapid development of VRC01-class antibodies in an HIV-1-infected Chinese donor  Academic Article
• Limited or no protection by weakly or nonneutralizing antibodies against vaginal shiv challenge of macaques compared with a strongly neutralizing antibody  Academic Article
• Manipulating the selection forces during affinity maturation to generate cross-reactive hiv antibodies  Academic Article
• Mapping the protein surface of human immunodeficiency virus type 1 gp120 using human monoclonal antibodies from phage display libraries  Academic Article
• Maturation pathway from germline to broad HIV-1 neutralizer of a CD4-mimic antibody  Academic Article
• Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody b12 that effectively targets the site of cd4 attachment  Academic Article
• Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01  Academic Article
• Mechanisms of escape from the PGT128 family of anti-HIV broadly neutralizing antibodies  Academic Article
• Mechanisms of neuronal injury and death in HIV-1 associated dementia  Academic Article
• Memantine prevents HIV coat protein-induced neuronal injury in vitro  Academic Article
• Migration of antigen-specific t cells away from cxcr4-binding human immunodeficiency virus type 1 gp120  Academic Article
• Mode of action for linear peptide inhibitors of hiv-1 gp120 interactions  Academic Article
• Modifications of the human immunodeficiency virus envelope glycoprotein enhance immunogenicity for genetic immunization  Academic Article
• Modifications that stabilize human immunodeficiency virus envelope glycoprotein trimers in solution  Academic Article
• Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies  Academic Article
• Molecular characterization of the circulating anti-hiv-1 gp120-specific b cell repertoire using antibody phage display libraries generated from pre-selected hiv-1 gp120 binding pbls  Academic Article
• Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120  Academic Article
• Molecular profile of an antibody-response to hiv-1 as probed by combinatorial libraries  Academic Article
• Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies  Academic Article
• Multiple antiviral activities of cyanovirin-n: Blocking of human immunodeficiency virus type 1 gp120 interaction with cd4 and coreceptor and inhibition of diverse enveloped viruses  Academic Article
• Mutagenesis and evolution of sulfated antibodies using an expanded genetic code  Academic Article
• Mutagenic stabilization and/or disruption of a cd4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein  Academic Article
• Mutations in the env gene of human immunodeficiency virus type 1 NDK isolates and the use of African green monkey CXCR4 as a co-receptor in COS-7 cells  Academic Article
• N-linked glycosylation in the CXCR4 N-tenninus inhibits binding to HIV-1 envelope glycoproteins  Academic Article
• N332-directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function  Academic Article
• Natural resistance of human immunodeficiency virus type 1 to the cd4bs antibody b12 conferred by a glycan and an arginine residue close to the cd4 binding loop  Academic Article
• Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1  Academic Article
• Neuronal apoptotic signaling pathways probed and intervened by synthetically and modularly modified (SMM) chemokines  Academic Article
• Neuronal injury due to HIV-1 envelope protein is blocked by anti-gp120 antibodies but not by anti-CD4 antibodies  Academic Article
• Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity  Academic Article
• Neutralizing activity of antibodies to the v3 loop region of hiv-1 gp120 relative to their epitope fine specificity  Academic Article
• Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation  Academic Article
• Neutralizing recombinant human-antibodies to a conformational v2-binding and cd4-binding site-sensitive epitope of hiv-1 gp120 isolated by using an epitope-masking procedure  Academic Article
• Nicotine prevents hivgp120-caused electrophysiological and motor disturbances in rats  Academic Article
• Nonneutralizing antibodies to the cd4-binding site on the gp120 subunit of human immunodeficiency virus type 1 do not interfere with the activity of a neutralizing antibody against the same site  Academic Article
• Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus  Academic Article
• Outer domain of HIV-1 gp120: antigenic optimization, structural malleability, and crystal structure with antibody VRC-PG04  Academic Article
• PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4  Academic Article
• Paramagnetic proteoliposomes containing a pure, native, and oriented seven-transmembrane segment protein, CCR5  Academic Article
• Passive immunization with a human monoclonal antibody protects hu-pbl-scid mice against challenge by primary isolates of hiv-1  Academic Article
• Permissive residues within the minimal epitopes of neutralizing monoclonal antibodies to the v3 loop of hiv-1  Academic Article
• Potent inhibition of hiv-1 entry with a chemically programmed antibody aided by an efficient organocatalytic synthesis  Academic Article
• Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to hiv-1 gp120  Academic Article
• Primary isolates of human-immunodeficiency-virus type-1 are relatively resistant to neutralization by monoclonal-antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120  Academic Article
• Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate  Academic Article
• Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen  Academic Article
• Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (hiv-1)  Academic Article
• Probing the structure of the human-immunodeficiency-virus surface glycoprotein gp120 with a panel of monoclonal-antibodies  Academic Article
• Production and characterization of human anti-V3 monoclonal antibodies from the cells of HIV-1 infected Indian donors  Academic Article
• Prolonged waking reduces human immunodeficiency virus glycoprotein 120- or tumor necrosis factor alpha-induced apoptosis in the cerebral cortex of rats  Academic Article
• Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV  Academic Article
• Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site  Academic Article
• Protein evolution with an expanded genetic code  Academic Article
• Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque  Academic Article
• Rational HIV immunogen design to target specific germline B cell receptors  Academic Article
• Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to hiv-1  Academic Article
• Reactivity-based one-pot synthesis of oligomannoses: Defining antigens recognized by 2g12, a broadly neutralizing anti-hiv-1 antibody  Academic Article
• Recognition properties of a panel of human recombinant fab fragments to the cd4 binding-site of gp120 that show differing abilities to neutralize human-immunodeficiency-virus type-1  Academic Article
• Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex  Academic Article
• Recombinant human fab fragments neutralize human type-1 immunodeficiency virus in vitro  Academic Article
• Recombinant human monoclonal antibody igg1b12 neutralizes diverse human immunodeficiency virus type 1 primary isolates  Academic Article
• Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop  Academic Article
• Redox-triggered infection by disulfide-shackled human immunodeficiency virus type 1 pseudovirions  Academic Article
• Relationship of hiv-1 and siv envelope glycoprotein trimer occupation and neutralization  Academic Article
• Relationship of the human-immunodeficiency-virus type-1 gp120 3rd variable loop to a component of the cd4 binding-site in the 4th conserved region  Academic Article
• Relative reactivity of HIV-1 polyclonal plasma antibodies directed to V3 and MPER regions suggests immunodominance of V3 over MPER and dependence of high anti-V3 antibody titers on virus persistence  Academic Article
• Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design  Academic Article
• Replication and neutralization of human immunodeficiency virus type 1 lacking the v1 and v2 variable loops of the gp120 envelope glycoprotein  Academic Article
• Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120  Academic Article
• Robust neutralizing antibodies elicited by HIV-1 JRFL envelope glycoprotein trimers in nonhuman primates  Academic Article
• Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization  Academic Article
• Scorpion-toxin mimics of cd4 in complex with human immunodeficiency virus gp120: Crystal structures, molecular mimicry, and neutralization breadth  Academic Article
• Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells  Academic Article
• Selection pressure on hiv-1 envelope by broadly neutralizing antibodies to the conserved cd4-binding site  Academic Article
• Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120  Academic Article
• Sequence and structural convergence of broad and potent hiv antibodies that mimic cd4 binding  Academic Article
• Sequential cd134-cxcr4 interactions in feline immunodeficiency virus (fiv): Soluble cd134 activates fiv env for cxcr4-dependent entry and reveals a cryptic neutralization epitope  Academic Article
• Simian immunodeficiency virus (siv) envelope-specific fabs with high-level homologous neutralizing activity: Recovery from a long-term-nonprogressor siv-infected macaque  Academic Article
• Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (hiv-1)-specific ipitopes: Replication, neutralization, and survey of hiv-1-positive plasma  Academic Article
• Similarity of neuronal cell injury and death in AIDS dementia and focal cerebral ischemia: Potential treatment with NMDA open-channel blockers and nitric oxide-related species  Academic Article
• Simplifying the synthesis of SIgA: combination of dIgA and rhSC using affinity chromatography  Academic Article
• Small-molecule cd4 mimics interact with a highly conserved pocket on hiv-1 gp120  Academic Article
• Small-molecule inhibitors: viral fusion arrested  Academic Article
• Soluble mimetics of human immunodeficiency virus type 1 viral spikes produced by replacement of the native trimerization domain with a heterologous trimerization motif: Characterization and ligand binding analysis  Academic Article
• Solution conformational preferences of immunogenic peptides derived from the principal neutralizing determinant of the HIV-1 envelope glycoprotein gp120  Academic Article
• Specific killing of hiv-infected lymphocytes by a recombinant immunotoxin directed against the hiv-1 envelope glycoprotein  Academic Article
• Stabilization of human immunodeficiency virus type 1 envelope glycoprotein trimers by disulfide bonds introduced into the gp41 glycoprotein ectodomain  Academic Article
• Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies  Academic Article
• Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01  Academic Article
• Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16  Academic Article
• Structural basis of immune evasion at the site of cd4 attachment on hiv-1 gp120  Academic Article
• Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120  Academic Article
• Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers  Academic Article
• Structural constraints determine the glycosylation of HIV-1 envelope trimers  Academic Article
• Structural definition of a conserved neutralization epitope on HIV-1 gp120  Academic Article
• Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers  Academic Article
• Structural evolution of glycan recognition by a family of potent HIV antibodies  Academic Article
• Structural interactions between chemokine receptors, gp120 Env and CD4  Academic Article
• Structural rationale for the broad neutralization of hiv-1 by human monoclonal antibody 447-52d  Academic Article
• Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors  Academic Article
• Structural studies of human HIV-1 V3 antibodies  Academic Article
• Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1  Academic Article
• Structure determination of an anti-hiv-1 fab 447-52d-peptide complex from an epitaxially twinned data set  Academic Article
• Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9  Academic Article
• Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies  Academic Article
• Structure of a v3-containing hiv-1 gp120 core  Academic Article
• Structure of an hiv gp120 envelope glycoprotein in complex with the cd4 receptor and a neutralizing human antibody  Academic Article
• Structure of antibody f425-b4e8 in complex with a v3 peptide reveals a new binding mode for hiv-1 neutralization  Academic Article
• Structure of hiv-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility  Academic Article
• Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex  Academic Article
• Structure-activity relationships in the binding of chemically derivatized cd4 to gp120 from human immunodeficiency virus  Academic Article
• Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site  Academic Article
• Structure-based stabilization of hiv-1 gp120 enhances humoral immune responses to the induced co-receptor binding site  Academic Article
• Structure-based vaccine design in hiv: Blind men and the elephant?  Academic Article
• Structure-based, targeted deglycosylation of hiv-1 gp120 and effects on neutralization sensitivity and antibody recognition  Academic Article
• Structures of hiv-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates  Academic Article
• Structures of the ccr5 n terminus and of a tyrosine-sulfated antibody with hiv-1 gp120 and cd4  Academic Article
• Structures of the cxcr4 chemokine gpcr with small-molecule and cyclic peptide antagonists  Academic Article
• Studies with monoclonal antibodies to the V3 region of HIV-1 gp120 reveal limitations to the utility of solid-phase peptide binding assays  Academic Article
• Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120  Academic Article
• Syndecan captures, protects, and transmits HIV to T lymphocytes  Academic Article
• Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity  Academic Article
• Synthesis of a trimeric gp120 epitope mimic conjugated to a t-helper peptide to improve antigenicity  Academic Article
• The bis-azo compound FP-21399 inhibits HIV-1 replication by preventing viral entry  Academic Article
• The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2g12 recognizes a cluster of α1→2 mannose residues on the outer face of gp120  Academic Article
• The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12  Academic Article
• The cell surface marker phenotype of macrophages from HIV-1-infected subjects reflects an IL-10-enriched and IFN-gamma-deprived donor environment  Academic Article
• The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid  Academic Article
• The contribution of various NOS gene products to HIV-1 coat protein (gp120)-mediated retinal ganglion cell injury  Academic Article
• The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies  Academic Article
• The envelope gp120 gene of human immunodeficiency virus type 1 determines the rate of CD4-positive T-cell depletion in SCID mice engrafted with human peripheral blood leukocytes  Academic Article
• The glycan shield of hiv is predominantly oligomannose independently of production system or viral clade  Academic Article
• Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in ca1 hippocampus  Academic Article
• Transplanting supersites of HIV-1 vulnerability  Academic Article
• Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures  Academic Article
• Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120  Academic Article
• Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry  Academic Article
• Tyrosine-sulfate isosteres of ccr5 n-terminus as tools for studying hiv-1 entry  Academic Article
• Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops  Academic Article
• Update on current models of HIV-related neuronal injury: platelet-activating factor, arachidonic acid and nitric oxide  Academic Article
• V1/V2 neutralizing epitope is conserved in divergent non-M groups of HIV-1  Academic Article
• Vaccine-elicited tier 2 HIV-1 neutralizing antibodies bind to quaternary epitopes involving glycan-deficient patches proximal to the CD4 binding site  Academic Article
• Variable loop glycan dependency of the broad and potent hiv-1-neutralizing antibodies pg9 and pg16  Academic Article
• Variation in hiv-i r5 macrophage-tropism correlates with sensitivity to reagents that block envelope: Cd4 interactions but not with sensitivity to other entry inhibitors  Academic Article
• Very few substitutions in a germ line antibody are required to initiate significant domain exchange  Academic Article
• [HIV glycoprotein 120: possible etiological agent of AIDS-associated dementia] [Article in Spanish]  Academic Article
• eCD4-Ig variants that more potently neutralize HIV-1  Academic Article
• gp120 and neurotoxicity in vivo  Academic Article