subject area of

• A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728  Academic Article
• A new congenital platelet abnormality characterized by spontaneous platelet aggregation, enhanced von Willebrand factor platelet interaction, and the presence of all von Willebrand factor multimers in plasma  Academic Article
• A new variant of type II von Willebrand disease with aberrant multimeric structure of plasma but not platelet von Willebrand factor (type IIF)  Academic Article
• A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib  Academic Article
• A sensitive ristocetin co-factor activity assay with recombinant glycoprotein Ib alpha for the diagnosis of patients with low von Willebrand factor levels  Academic Article
• A sequence analysis of von Willebrand factor mRNA, gene, and pseudogene in two patients with von Willebrand disease type 2B, and an investigation of gene conversion in its gene  Academic Article
• A type 2b von Willebrand disease mutation (Ile546 -> Val) associated with an unusual phenotype  Academic Article
• ADAP is required for normal alpha IIb beta 3 activation by VWF/GP Ib-IX-V and other agonists  Academic Article
• ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion  Academic Article
• Aberrant multimeric structure of von Willebrand factor in a new variant of von Willebrand's disease (type IIC)  Academic Article
• Acquired abnormalities of von Willebrand factor: facts to consider in patients with unexpected bleeding  Academic Article
• Acquired von Willebrand's disease in the myeloproliferative syndrome  Academic Article
• Activation-independent platelet adhesion and aggregation under elevated shear stress  Academic Article
• Adhesive properties of the isolated amino-terminal domain of platelet glycoprotein Ib alpha in a flow field  Academic Article
• Altered von Willebrand factor subunit proteolysis and multimer processing associated with the Cys2362Phe mutation in the B2 domain  Academic Article
• Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib  Academic Article
• An association of candidate gene haplotypes and bleeding severity in von willebrand disease type 2a, 2b, and 2m pedigrees  Academic Article
• Analysis of structure-function relationships in the platelet membrane glycoprotein Ib-binding domain of von Willebrand's factor by expression of deletion mutants  Academic Article
• Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen  Academic Article
• Are integrin alpha(2)beta(1), glycoprotein Ib and vWf levels correlated with their contributions to platelet adhesion on collagen under high-shear flow?  Academic Article
• Carbohydrate composition and identification of blood group A, B, and H oligosaccharide structures on human Factor VIII/von Willebrand factor  Academic Article
• Carbohydrate moiety of von Willebrand factor is not necessary for maintaining multimeric structure and ristocetin cofactor activity but protects from proteolytic degradation  Academic Article
• Carbohydrate of the factor VIII/von Willebrand factor in von Willebrand's disease  Academic Article
• Carbohydrate on human factor viii von willebrand factor - impairment of function by removal of specific galactose residues  Academic Article
• Characterization of a fragment of bovine von Willebrand factor that binds to platelets  Academic Article
• Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets  Academic Article
• Classification of variant von Willebrand's disease subtypes by analysis of functional characteristics and multimeric composition of factor VIII/von Willebrand factor  Academic Article
• Cloning of the murine platelet glycoprotein Ib alpha gene highlighting species-specific platelet adhesion  Academic Article
• Comparison of in vitro and in vivo approaches to studying brain colonization by breast cancer cells  Academic Article
• Conformational changes in the A1 domain of von Willebrand factor modulating the interaction with platelet glycoprotein Ibα  Academic Article
• Contribution of distinct adhesive interactions to platelet aggregation in flowing blood  Academic Article
• Conversion of human fibroblasts to functional endothelial cells by defined factors  Academic Article
• Correlation between circulating levels of von Willebrand's antigen II and von Willebrand factor: discrimination between type I and type II von Willebrand's disease  Academic Article
• Crystal structure of NMC-4 fab anti-von Willebrand factor A1 domain  Academic Article
• Crystal structure of the von Willebrand factor A1 domain in complex with the function blocking NMC-4 Fab  Academic Article
• Crystal structure of the von Willebrand factor modulator botrocetin  Academic Article
• Defective dimerization of von Willebrand factor subunits due to a Cys -> Arg mutation in type IID von Willebrand disease  Academic Article
• Developing basic and clinical research on von Willebrand factor and von Willebrand disease  Academic Article
• Differences between heterozygous dominant and recessive von Willebrand's disease type I expressed by bleeding symptoms and combinations of factor VIII variables  Academic Article
• Distinct abnormalities in the interaction of purified types IIA and IIB von Willebrand factor with the two platelet binding sites, glycoprotein complexes Ib-IX and IIb-IIIa  Academic Article
• Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions  Academic Article
• Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow  Academic Article
• Distinct structural attributes regulating von Willebrand factor A1 domain interaction with platelet glycoprotein Ib alpha under flow  Academic Article
• Disulfide bond requirements for assembly of the platelet glycoprotein Ib-binding domain of von Willebrand factor  Academic Article
• Elevated platelet count as a cause of abnormal von Willebrand factor multimer distribution in plasma  Academic Article
• Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage  Academic Article
• Enhanced botrocetin-induced type IIB von Willebrand factor binding to platelet glycoprotein Ib initiates hyperagglutination of normal platelets  Academic Article
• Enhanced shear-induced platelet aggregation in acute myocardial infarction  Academic Article
• Epitope mapping of the von Willebrand factor subunit distinguishes fragments present in normal and type IIA von Willebrand disease from those generated by plasmin  Academic Article
• Evidence of activation of the protein-c pathway during acute vascular damage induced by mediterranean spotted-fever  Academic Article
• Evidence that the Arg1744 Gly1745 Asp1746 sequence in the GPIIb-IIIa-binding domain of von Willebrand factor is involved in platelet adhesion and thrombus formation on subendothelium  Academic Article
• Expression and characterization of von Willebrand factor dimerization defects in different types of von Willebrand disease  Academic Article
• Expression of human platelet glycoprotein Ib alpha in transgenic mice  Academic Article
• Expression of the phenotypic abnormality of platelet-type von Willebrand disease in a recombinant glycoprotein Ib alpha fragment  Academic Article
• Factor VIII/von Willebrand factor  Academic Article
• Factor VIII/von Willebrand factor in glomerular nephropathies  Academic Article
• Factor-VIII-related antigen: multiple molecular forms in human plasma  Academic Article
• Familial incidence of precipitating antibodies in von Willebrand's disease: A study of four cases  Academic Article
• Fine mapping of monoclonal antibody epitopes on human von Willebrand factor using a recombinant peptide library  Academic Article
• Functional modulation of the isolated glycoprotein Ib binding domain of von Willebrand factor expressed in Escherichia coli  Academic Article
• Functional self-association of von Willebrand factor during platelet adhesion under flow  Academic Article
• Further characterization of platelet-type von Willebrand's disease in Japan  Academic Article
• Generation and characterization of peptide-specific antibodies that inhibit von Willebrand factor binding to glycoprotein IIb-IIIa without interacting with other adhesive molecules. Selectivity is conferred by Pro1743 and other amino acid residues adjacent to the sequence Arg1744-Gly1745-Asp1746  Academic Article
• Generation and characterization of specific antibodies directed to the binding domain of adhesive molecules  Academic Article
• Genetics of platelet reactivity in normal, healthy individuals  Academic Article
• Glanzmann thrombasthenia: deficient binding of von Willebrand factor to thrombin-stimulated platelets  Academic Article
• Glycoprotein Ib and von Willebrand factor in the process of thrombus formation  Academic Article
• Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2  Academic Article
• Heightened interaction between platelets and factor VIII/von Willebrand factor in a new subtype of von Willebrand's disease  Academic Article
• Heparin-associated thrombocytopenia: observations on the mechanism of platelet aggregation  Academic Article
• Heterogeneity of plasma von Willebrand factor multimers resulting from proteolysis of the constituent subunit  Academic Article
• High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIb alpha-filamin interaction  Academic Article
• High-resolution analysis of von Willebrand factor multimeric composition defines a new variant of type I von Willebrand disease with aberrant structure but presence of all size multimers (type IC)  Academic Article
• Homozygous and heterozygous deletions of the von Willebrand factor gene in patients and carriers of severe von Willebrand disease  Academic Article
• Hybridoma antibodies to human von Willebrand factor. I. Characterization of seven clones  Academic Article
• Hybridoma antibodies to human von willebrand factor .2. Relative role of intramolecular loci in mediation of platelet-adhesion to the subendothelium  Academic Article
• Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor  Academic Article
• Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor  Academic Article
• Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding  Academic Article
• Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin. A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib  Academic Article
• Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding  Academic Article
• In vitro and in vivo consequences of mutations in the von Willebrand factor cleaving protease ADAMTS13 in thrombotic thrombocytopenic purpura  Academic Article
• In vivo relevance for platelet glycoprotein Ib alpha residue Tyr276 in thrombus formation  Academic Article
• Increased fragmentation of von Willebrand factor, due to abnormal cleavage of the subunit, parallels disease activity in recurrent hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and discloses predisposition in families  Academic Article
• Increased thrombogenesis and embolus formation in mice lacking glycoprotein V  Academic Article
• Independent assembly and secretion of a dimeric adhesive domain of von Willebrand factor containing the glycoprotein Ib-binding site  Academic Article
• Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody  Academic Article
• Indications for a protective function of beta(2)-glycoprotein I in thrombotic thrombocytopenic purpura  Academic Article
• Influence of fibrillar collagen structure on the mechanisms of platelet thrombus formation under flow  Academic Article
• Inhibition of platelet-vessel wall interaction. Platelet receptors, monoclonal antibodies, and synthetic peptides  Academic Article
• Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor  Academic Article
• Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation  Academic Article
• Interaction of purified type IIB von Willebrand factor with the platelet membrane glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and initiates aggregation  Academic Article
• Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants  Academic Article
• Isoelectric focusing of human von Willebrand factor in urea-agarose gels  Academic Article
• Isolation and characterization of a collagen binding domain in human von Willebrand factor  Academic Article
• Isolation and characterization of two domains of human von Willebrand factor that interact with fibrillar collagen types I and III  Academic Article
• Isolation and chemical characterization of two structurally and functionally distinct forms of botrocetin, the platelet coagglutinin isolated from the venom of Bothrops jararaca  Academic Article
• Isolation and functional characterization of the von Willebrand factor-binding domain located between residues His1-Arg293 of the alpha-chain of glycoprotein Ib  Academic Article
• Isolation of the von Willebrand factor domain interacting with platelet glycoprotein Ib, heparin, and collagen and characterization of its three distinct functional sites  Academic Article
• Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha(IIb)beta(3)  Academic Article
• Luminographic detection of von Willebrand factor multimers in agarose gels and on nitrocellulose membranes  Academic Article
• Mapping of distinct von Willebrand factor domains interacting with platelet GPIb and GPIIb/IIIa and with collagen using monoclonal antibodies  Academic Article
• Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress  Academic Article
• Mechanisms initiating platelet thrombus formation  Academic Article
• Megakaryocytes produce the receptor for granulocyte colony-stimulating factor  Academic Article
• Modeling and functional analysis of the interaction between von Willebrand factor A1 domain and glycoprotein Ib alpha  Academic Article
• Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin alpha IIb beta 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor  Academic Article
• Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature  Academic Article
• Multimeric composition of factor VIII/von Willebrand factor following administration of DDAVP: implications for pathophysiology and therapy of von Willebrand's disease subtypes  Academic Article
• Multimeric structure of platelet factor VIII/von Willebrand factor: the presence of larger multimers and their reassociation with thrombin-stimulated platelets  Academic Article
• Multiple epitope specificity of monoclonal antibodies to a single synthetic peptide: use in the characterization of the GP IIb-IIIa binding domain of von Willebrand factor  Academic Article
• New insights into the mechanisms of platelet adhesion and aggregation  Academic Article
• New perspectives on von Willebrand factor functions in hemostasis and thrombosis  Academic Article
• Non-invasive multimodality imaging directly shows TRPM4 inhibition ameliorates stroke reperfusion injury  Academic Article
• Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane  Academic Article
• Old concepts and new developments in the study of platelet aggregation  Academic Article
• Optimization of a recombinant von Willebrand factor fragment as an antagonist of the platelet glycoprotein Ib receptor  Academic Article
• Pathogenesis and classification of von Willebrand disease  Academic Article
• Platelet GPIb: sensing force and responding  Academic Article
• Platelet aggregation on extracellular matrix: effect of a recombinant GPIb-binding fragment of von Willebrand factor  Academic Article
• Platelet and von Willebrand factor interactions at the vessel wall  Academic Article
• Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease  Academic Article
• Platelet function and arterial thrombosis  Academic Article
• Platelet interactions with vessel wall components during thrombogenesis  Academic Article
• Platelets adhere to and translocate on von Willebrand factor presented by endothelium in simulated veins  Academic Article
• Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage  Academic Article
• Platelets and von Willebrand disease  Academic Article
• Platelets have more than one binding site for von Willebrand factor  Academic Article
• Platelets with a W127X mutation in GPIX express sufficient residual amounts of GPIbα to support adhesion to von Willebrand factor and collagen  Academic Article
• Precipitating antibodies to factor VIII/von Willebrand factor in von Willebrand's disease: effects on replacement therapy  Academic Article
• Proteolysis of von Willebrand factor and shear stress-induced platelet aggregation in patients with aortic valve stenosis  Academic Article
• Proteolysis of von Willebrand factor in therapeutic plasma concentrates  Academic Article
• Proteolytic degradation of von Willebrand factor after DDAVP administration in normal individuals  Academic Article
• Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets  Academic Article
• Regulation of von Willebrand factor binding to the platelet glycoprotein Ib-IX by a membrane skeleton-dependent inside-out signal  Academic Article
• Reversible activation defect of the platelet glycoprotein IIb-IIIa complex in patients with uremia  Academic Article
• Role of von Willebrand factor in platelet thrombus formation  Academic Article
• Secretion of von Willebrand factor from platelets  Academic Article
• Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ib alpha mechanoreceptor  Academic Article
• Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors  Academic Article
• Site-directed mutagenesis of a soluble recombinant fragment of platelet glycoprotein Ib alpha demonstrating negatively charged residues involved in von Willebrand factor binding  Academic Article
• Size regulation of von Willebrand factor-mediated platelet thrombi by ADAMTS13 in flowing blood  Academic Article
• Spectrum of von Willebrand's Disease: a study of 100 cases  Academic Article
• Spontaneous platelet aggregation in type IIB Tampa von Willebrand disease is inhibited by the 52/48-kDa fragment of normal von Willebrand factor, which contains the GPIb binding domain  Academic Article
• Structure and function of the von Willebrand factor A1 domain  Academic Article
• Structure and function of von Willebrand factor  Academic Article
• Structure and function of von Willebrand factor: relationship to von Willebrand's disease  Academic Article
• Structure of the von Willebrand factor domain interacting with glycoprotein Ib  Academic Article
• Structure of von Willebrand factor and its function in platelet adhesion and thrombus formation  Academic Article
• Subunit composition of plasma von Willebrand factor in patients with the myeloproliferative syndrome  Academic Article
• Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE)  Academic Article
• Synthetic peptides inhibit the interaction of von Willebrand factor-platelet membrane glycoproteins  Academic Article
• The complex multimeric composition of factor VIII/von Willebrand factor  Academic Article
• The effect of DDAVP on plasma levels of von Willebrand antigen II in normal individuals and patients with von Willebrand's disease  Academic Article
• The heterogeneity of type IIA von Willebrand's disease: studies with protease inhibitors  Academic Article
• The role of platelet adhesion receptor GPIb alpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis  Academic Article
• The role of the porcine von Willebrand factor: baboon platelet interactions in pulmonary xenotransplantation  Academic Article
• The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress  Academic Article
• The role of von Willebrand factor and fibrinogen in the initiation of platelet adhesion to thrombogenic surfaces  Academic Article
• The role of von Willebrand factor in thrombus formation  Academic Article
• The structure and function of von Willebrand factor  Academic Article
• The von Willebrand factor domain-mediating botrocetin-induced binding to glycoprotein IB lies between Val449 and Lys728  Academic Article
• The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments  Academic Article
• Tissue distribution and regulation of murine von Willebrand factor gene expression in vivo  Academic Article
• Tissue distribution of factor VIII gene expression in vivo: a closer look  Academic Article
• Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation  Academic Article
• Type IIB von Willebrand disease: a paradox explains how von Willebrand factor works  Academic Article
• Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin. Role of platelet activation, fibrinogen, and two distinct membrane receptors  Academic Article
• Type IIB von Willebrand's disease: differential clearance of endogenous versus transfused large multimer von willebrand factor  Academic Article
• Unique interactions of asialo von Willebrand factor with platelets in platelet-type von Willebrand disease  Academic Article
• Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein lb  Academic Article
• Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor  Academic Article
• Variant Bernard-Soulier syndrome type bolzano. A congenital bleeding disorder due to a structural and functional abnormality of the platelet glycoprotein Ib-IX complex  Academic Article
• Variant von Willebrand's disease: characterization of two subtypes by analysis of multimeric composition of factor VIII/von Willebrand factor in plasma and platelets  Academic Article
• [Further evaluation of GPIb binding domain of vWf by synthetic peptides][Article in Japanese]  Academic Article
• [Multimeric structure of factor VIII/von Willebrand factor released from human platelets by ADP, collagen and thrombin][Article in Spanish]  Academic Article
• von Willebrand disease  Academic Article
• von Willebrand disease type IIC with different abnormalities of von Willebrand factor in the same sibship  Academic Article
• von Willebrand factor  Academic Article
• von Willebrand factor  Academic Article
• von Willebrand factor  Academic Article
• von Willebrand factor  Academic Article
• von Willebrand factor and fibrinogen  Academic Article
• von Willebrand factor and von Willebrand disease  Academic Article
• von Willebrand factor as a target for antithrombotic intervention  Academic Article
• von Willebrand factor binding to platelet glycoprotein Ib complex  Academic Article
• von Willebrand factor binds to platelets and induces aggregation in platelet-type but not type IIB von Willebrand disease  Academic Article
• von Willebrand factor competes with fibrin for occupancy of GPIIb:IIIa on thrombin-stimulated platelets  Academic Article
• von Willebrand factor conformation and adhesive function is modulated by an internalized water molecule  Academic Article
• von Willebrand factor has more than one binding site for platelets  Academic Article
• von Willebrand factor interaction with the glycoprotein IIb/IIa complex. Its role in platelet function as demonstrated in patients with congenital afibrinogenemia  Academic Article
• von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure  Academic Article
• von Willebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism  Academic Article
• von Willebrand factor, now cloned  Academic Article
• von Willebrand factor, platelets and endothelial cell interactions  Academic Article
• von Willebrand factor. A reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein Ib  Academic Article
• von Willebrand factor: looking back and looking forward  Academic Article
• von Willebrand's Disease  Academic Article
• von Willebrand's disease  Academic Article
• von Willebrand's disease and the mechanisms of platelet function  Academic Article