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Thiophenes

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  • A brief review of the past and future of platelet P2Y12 antagonist  Academic Article
  • A new regulatory switch in a JAK protein kinase  Academic Article
  • A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties  Academic Article
  • Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry  Academic Article
  • Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools  Academic Article
  • Anti-proliferative actions of a synthetic REV-ERBα/β agonist in breast cancer cells  Academic Article
  • Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)  Academic Article
  • Cd69 down-modulation and inhibition of thymic egress by short- and long-term selective chemical agonism of sphingosine 1-phosphate receptors  Academic Article
  • Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase  Academic Article
  • Design and synthesis of novel glycopolythiophene assemblies for colorimetric detection of influenza virus and e-coli  Academic Article
  • Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer  Academic Article
  • Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trial  Academic Article
  • Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats  Academic Article
  • Effects of selective estrogen receptor modulators (serms) on coactivator nuclear receptor (nr) box binding to estrogen receptors  Academic Article
  • Fragment-based screen against HIV protease  Academic Article
  • Grignard cross-coupling amenable to large scale production of alpha-fluorostyryl and alpha-fluorovinylthiophenes  Academic Article
  • Grooved nanowires from self-assembling hairpin molecules for solar cells  Academic Article
  • Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin d receptor modulators  Academic Article
  • Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1)  Academic Article
  • Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo 2.2.1 hept-2-ene-7-oxide  Academic Article
  • Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor  Academic Article
  • Identification of HIV-1 inhibitors targeting the nucleocapsid protein  Academic Article
  • Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist  Academic Article
  • Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB  Academic Article
  • Identification of a small molecule with activity against drug-resistant and persistent tuberculosis  Academic Article
  • In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1  Academic Article
  • Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models  Academic Article
  • Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells  Academic Article
  • Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics  Academic Article
  • Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition  Academic Article
  • Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungs  Academic Article
  • Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence  Academic Article
  • Pharmacological and genetic modulation of REV-ERB activity and expression affects orexigenic gene expression  Academic Article
  • Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour  Academic Article
  • Platelet-mediated thrombosis and drug-eluting stents  Academic Article
  • Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury  Academic Article
  • Pyrazole-based cathepsin S inhibitors with improved cellular potency  Academic Article
  • Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists  Academic Article
  • S1P1 receptor localization confers selectivity for Gi mediated cAMP and contractile responses  Academic Article
  • S1p(1)-selective in vivo-active agonists from high-throughput screening: Off-the-shelf chemical probes of receptor interactions, signaling, and fate  Academic Article
  • S1p1-selective agonist sew2871 exacerbates reperfusion arrhythmias  Academic Article
  • Selective arylthiolane deprotection by singlet oxygen: a promising tool for sensors and prodrugs  Academic Article
  • Self-assembly and conductivity of hydrogen-bonded oligothiophene nanofiber networks  Academic Article
  • Self-assembly and orientation of hydrogen-bonded oligothiophene polymorphs at liquid-membrane-liquid interfaces  Academic Article
  • Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erb alpha  Academic Article
  • Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary t cells to lymphatic sinuses  Academic Article
  • Stability and selectivity of unnatural DNA with five-membered-ring nucleobase analogues  Academic Article
  • Strained cyclic disulfides enable cellular uptake by reacting with the transferrin receptor  Academic Article
  • Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs  Academic Article
  • Structure-based design of thienobenzoxepin inhibitors of PI3-kinase  Academic Article
  • Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: A new wrinkle in botulinum neurotoxin  Academic Article
  • Synthesis and evaluation of a thio analogue of duocarmycin SA  Academic Article
  • Synthetic inhibitors of cytochrome p-450 2a6: Inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization  Academic Article
  • The effect of minor-groove hydrogen-bond acceptors and donors on the stability and replication of four unnatural base pairs  Academic Article
  • Thiophene-core estrogen receptor ligands having superagonist activity  Academic Article
  • Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection  Academic Article

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