subject area of
- A brief review of the past and future of platelet P2Y12 antagonist Academic Article
- A new regulatory switch in a JAK protein kinase Academic Article
- A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties Academic Article
- Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry Academic Article
- Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools Academic Article
- Anti-proliferative actions of a synthetic REV-ERBα/β agonist in breast cancer cells Academic Article
- Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH) Academic Article
- Cd69 down-modulation and inhibition of thymic egress by short- and long-term selective chemical agonism of sphingosine 1-phosphate receptors Academic Article
- Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase Academic Article
- Design and synthesis of novel glycopolythiophene assemblies for colorimetric detection of influenza virus and e-coli Academic Article
- Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer Academic Article
- Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trial Academic Article
- Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats Academic Article
- Effects of selective estrogen receptor modulators (serms) on coactivator nuclear receptor (nr) box binding to estrogen receptors Academic Article
- Fragment-based screen against HIV protease Academic Article
- Grignard cross-coupling amenable to large scale production of alpha-fluorostyryl and alpha-fluorovinylthiophenes Academic Article
- Grooved nanowires from self-assembling hairpin molecules for solar cells Academic Article
- Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin d receptor modulators Academic Article
- Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1) Academic Article
- Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo 2.2.1 hept-2-ene-7-oxide Academic Article
- Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor Academic Article
- Identification of HIV-1 inhibitors targeting the nucleocapsid protein Academic Article
- Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist Academic Article
- Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB Academic Article
- Identification of a small molecule with activity against drug-resistant and persistent tuberculosis Academic Article
- In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1 Academic Article
- Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models Academic Article
- Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells Academic Article
- Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics Academic Article
- Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition Academic Article
- Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungs Academic Article
- Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence Academic Article
- Pharmacological and genetic modulation of REV-ERB activity and expression affects orexigenic gene expression Academic Article
- Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour Academic Article
- Platelet-mediated thrombosis and drug-eluting stents Academic Article
- Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury Academic Article
- Pyrazole-based cathepsin S inhibitors with improved cellular potency Academic Article
- Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists Academic Article
- S1P1 receptor localization confers selectivity for Gi mediated cAMP and contractile responses Academic Article
- S1p(1)-selective in vivo-active agonists from high-throughput screening: Off-the-shelf chemical probes of receptor interactions, signaling, and fate Academic Article
- S1p1-selective agonist sew2871 exacerbates reperfusion arrhythmias Academic Article
- Selective arylthiolane deprotection by singlet oxygen: a promising tool for sensors and prodrugs Academic Article
- Self-assembly and conductivity of hydrogen-bonded oligothiophene nanofiber networks Academic Article
- Self-assembly and orientation of hydrogen-bonded oligothiophene polymorphs at liquid-membrane-liquid interfaces Academic Article
- Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erb alpha Academic Article
- Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary t cells to lymphatic sinuses Academic Article
- Stability and selectivity of unnatural DNA with five-membered-ring nucleobase analogues Academic Article
- Strained cyclic disulfides enable cellular uptake by reacting with the transferrin receptor Academic Article
- Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Academic Article
- Structure-based design of thienobenzoxepin inhibitors of PI3-kinase Academic Article
- Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: A new wrinkle in botulinum neurotoxin Academic Article
- Synthesis and evaluation of a thio analogue of duocarmycin SA Academic Article
- Synthetic inhibitors of cytochrome p-450 2a6: Inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization Academic Article
- The effect of minor-groove hydrogen-bond acceptors and donors on the stability and replication of four unnatural base pairs Academic Article
- Thiophene-core estrogen receptor ligands having superagonist activity Academic Article
- Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection Academic Article