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Recombinant Fusion Proteins

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  • 4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms  Academic Article
  • A CCHC metal-binding domain in Nanos is essential for translational regulation  Academic Article
  • A P element with a novel fusion of reporters identifies regular, a C2H2 zinc-finger gene downstream of the circadian clock  Academic Article
  • A binding site for homeodomain and pax proteins is necessary for l1 cell adhesion molecule gene expression by pax-6 and bone morphogenetic proteins  Academic Article
  • A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding  Academic Article
  • A chimeric hiv-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (gm-csf) domain induces enhanced antibody and t cell responses  Academic Article
  • A chromatin binding-site in the tail domain of nuclear lamins that interacts with core histones  Academic Article
  • A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease  Academic Article
  • A conformational transition at the n terminus of the prion protein features in formation of the scrapie isoform  Academic Article
  • A conserved MutS homolog connector domain interface interacts with MutL homologs  Academic Article
  • A critical role for tyrosine residues in his(6)ni-mediated protein cross-linking  Academic Article
  • A di-acidic signal required for selective export from the endoplasmic reticulum  Academic Article
  • A dimerization "switch" in the internalization mechanism of a cell-penetrating peptide  Academic Article
  • A disease-specific measure of health-related quality of life in adults with chronic immune thrombocytopenic purpura: Psychometric testing in an open-label clinical trial  Academic Article
  • A dual-function DNA vaccine encoding carcinoembryonic antigen and cd40 ligand trimer induces t cell-mediated protective immunity against colon cancer in carcinoembryonic antigen-transgenic mice  Academic Article
  • A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol)  Academic Article
  • A functional interaction between RIP140 and PGC-1 alpha regulates the expression of the lipid droplet protein CIDEA  Academic Article
  • A fusion protein system for the recombinant production of short disulfide-containing peptides  Academic Article
  • A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain  Academic Article
  • A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly  Academic Article
  • A general strategy for the bacterial expression of amyloidogenic peptides using BCL-XL-1/2 fusions  Academic Article
  • A general system for evaluating the efficiency of chromophore-assisted light inactivation (CALI) of proteins reveals Ru(ii) tris-bipyridyl as an unusually efficient "warhead"  Academic Article
  • A genetic analysis of pax3-fkhr, the oncogene of alveolar rhabdomyosarcoma  Academic Article
  • A gfp-equipped bidirectional expression module well suited for monitoring tetracycline-regulated gene expression in mouse  Academic Article
  • A global metabolite profiling approach to identify protein-metabolite interactions  Academic Article
  • A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs  Academic Article
  • A hingeless Fc fusion system for site-specific cleavage by IdeS  Academic Article
  • A maltose-binding protein fusion construct yields a robust crystallography platform for MCL1  Academic Article
  • A mechanism for microtubule depolymerization by kini kinesins  Academic Article
  • A nanobody:GFP bacterial platform that enables functional enzyme display and easy quantification of display capacity  Academic Article
  • A new functional domain of guanine nucleotide dissociation inhibitor (alpha-gdi) involved in rab recycling  Academic Article
  • A new strategy for glycoprotein synthesis: ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as TEV protease cleavable fusion protein  Academic Article
  • A next-generation cleaved, soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies  Academic Article
  • A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis  Academic Article
  • A novel circadian phenotype based on firefly luciferase expression in transgenic plants  Academic Article
  • A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma  Academic Article
  • A novel high-affinity human monoclonal antibody to mesothelin  Academic Article
  • A novel method for high-level production of TEV protease by superfolder GFP tag  Academic Article
  • A novel multiple affinity purification tag and its use in identification of proteins associated with a cyclin-CDK complex  Academic Article
  • A novel promoter motif for caulobacter cell cycle-controlled DNA replication genes  Academic Article
  • A peptide core motif for binding to heterotrimeric G protein α subunits  Academic Article
  • A plant-like kinase in plasmodium falciparum regulates parasite egress from erythrocytes  Academic Article
  • A potent transactivation domain mimic with activity in living cells  Academic Article
  • A proximity based general method for identification of ligand and receptor interactions in living cells  Academic Article
  • A quail long-term cell-culture transformed by a chimeric jun oncogene  Academic Article
  • A recombinant antibody interleukin-2 fusion protein suppresses growth of hepatic human neuroblastoma metastases in severe combined immunodeficiency mice  Academic Article
  • A role for peroxisomes in photomorphogenesis and development of Arabidopsis  Academic Article
  • A role for ranbp1 in the release of crm1 from the nuclear pore complex in a terminal step of nuclear export  Academic Article
  • A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis  Academic Article
  • A selective tumor microvasculature thrombogen that targets a novel receptor complex in the tumor angiogenic microenvironment  Academic Article
  • A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth  Academic Article
  • A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors  Academic Article
  • A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins  Academic Article
  • A soluble single-chain T-cell receptor IL-2 fusion protein retains MHC-restricted peptide specificity and IL-2 bioactivity  Academic Article
  • A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle  Academic Article
  • A structural role of histidine 15 in human glutathione transferase M1-1, an amino acid residue conserved in class Mu enzymes  Academic Article
  • A transcriptional switch mediated by cofactor methylation  Academic Article
  • A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity  Academic Article
  • A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli  Academic Article
  • AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation  Academic Article
  • ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein  Academic Article
  • Aak1-mediated mu 2 phosphorylation is stimulated by assembled clathrin  Academic Article
  • Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells  Academic Article
  • Activated protein C reduces graft neutrophil activation in clinical renal transplantation  Academic Article
  • Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1  Academic Article
  • Activation of a Ca(2+)-dependent protein kinase involves intramolecular binding of a calmodulin-like regulatory domain  Academic Article
  • Activation of a beta 2-adrenergic receptor/gs alpha fusion protein elicits a desensitization-resistant camp signal capable of inhibiting proliferation of two cancer cell lines  Academic Article
  • Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor vii  Academic Article
  • Activation of cyclin e/cdk2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin e  Academic Article
  • Activation of human effector cells by a tumor reactive recombinant anti-ganglioside gd(2) interleukin-2 fusion protein (ch14.18-il2)  Academic Article
  • Activation of multidrug resistance (P-glycoprotein) mdr3/mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice  Academic Article
  • Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation  Academic Article
  • Activity-guided engineering of natural product carrier proteins  Academic Article
  • Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells  Academic Article
  • Administration of recombinant p-selectin glycoprotein ligand fc fusion protein suppresses inflammation and neointimal formation in zucker diabetic rat model  Academic Article
  • Adp-ribosylation factor 4 small gtpase mediates epidermal growth factor receptor-dependent phospholipase d2 activation  Academic Article
  • Affinity purification of protein complexes in C. elegans  Academic Article
  • Affinity-based assay of Rho guanosine triphosphatase activation  Academic Article
  • Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation  Academic Article
  • Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors  Academic Article
  • Allosteric modulation of ampa-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, n-cam  Academic Article
  • Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system  Academic Article
  • Altered trafficking of FAS and subsequent resistance to FAS-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma  Academic Article
  • Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head  Academic Article
  • Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome  Academic Article
  • Amg 531, a thrombopoiesis-stimulating protein, for chronic itp  Academic Article
  • An E. coli aminoacyl-tRNA synthetase can substitute for yeast mitochondrial enzyme function in vivo  Academic Article
  • An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis  Academic Article
  • An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cells  Academic Article
  • An antagonist peptide epo receptor complex suggests that receptor dimerization is not sufficient for activation  Academic Article
  • An antibody CDR3-erythropoietin fusion protein  Academic Article
  • An antibody-interleukin 2 fusion protein overcomes tumor heterogeneity by induction of a cellular immune response  Academic Article
  • An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct  Academic Article
  • An efficient platform for genetic selection and screening of gene switches in Escherichia coli  Academic Article
  • An efficient platform for screening expression and crystallization of glycoproteins produced in human cells  Academic Article
  • An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system  Academic Article
  • An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation  Academic Article
  • An inhibitor of sequence-specific proteolysis that targets the substrate rather than the enzyme  Academic Article
  • An ultra-high throughput cell-based screen for wee1 degradation inhibitors  Academic Article
  • Analysis of bacteriophage N protein and peptide binding to boxB RNA using polyacrylamide gel coelectrophoresis (PACE)  Academic Article
  • Analysis of cell-cell contact mediated by Ig superfamily cell adhesion molecules  Academic Article
  • Analysis of hapten binding and catalytic determinants in a family of catalytic antibodies  Academic Article
  • Analysis of nuclear protein import and export in vitro using fluorescent cargoes  Academic Article
  • Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex  Academic Article
  • Analysis of the epitopes of proliferating cell nuclear antigen recognized by monoclonal antibodies  Academic Article
  • Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera  Academic Article
  • Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis b surface antigen particles  Academic Article
  • Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein  Academic Article
  • Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for beta-Pix in negative regulation of focal adhesion maturation  Academic Article
  • Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins  Academic Article
  • Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies  Academic Article
  • Antibody targeted drugs as cancer therapeutics  Academic Article
  • Antibody-il-12 fusion proteins are effective in scid mouse models of prostate and colon carcinoma metastases  Academic Article
  • Antibody-interleukin 2 fusion proteins: A new approach to cancer therapy  Academic Article
  • Antibody-targeted interleukin-2 stimulates t-cell killing of autologous tumor-cells  Academic Article
  • Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy  Academic Article
  • Antigenic and immunologic characterization of an allogeneic colon carcinoma vaccine  Academic Article
  • Ap-2/eps15 interaction is required for receptor-mediated endocytosis  Academic Article
  • Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors  Academic Article
  • Architecture of cannabinoid signaling in mouse retina  Academic Article
  • Arf tumor suppressor promoter monitors latent oncogenic signals in vivo  Academic Article
  • Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes  Academic Article
  • Artificial oncoproteins: Modified versions of the yeast bzip protein gcn4 induce cellular transformation  Academic Article
  • Assays used to study the DNA replication checkpoint in fission yeast  Academic Article
  • Assembly of combinatorial antibody libraries on phage surfaces - the gene-iii site  Academic Article
  • Association of ca(v)1.3 l-type calcium channels with shank  Academic Article
  • Astrocyte-specific expression of hamster prion protein (prp) renders prp knockout mice susceptible to hamster scrapie  Academic Article
  • Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor  Academic Article
  • Attenuation of phytochrome A and B signaling pathways by the Arabidopsis circadian clock  Academic Article
  • Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface  Academic Article
  • BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein  Academic Article
  • Bacillus subtilis hydrolyzes chey-p at the location of its action, the flagellar switch  Academic Article
  • Bacterial chemoreceptor dynamics correlate with activity state and are coupled over long distances  Academic Article
  • Bacterial expression of tenecin 3, an insect antifungal protein isolated from tenebrio molitor, and its efficient purification  Academic Article
  • Barx2, a new homeobox gene of the bar class, is expressed in neural and craniofacial structures during development  Academic Article
  • Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases  Academic Article
  • Bcl-2 is an apoptotic target suppressed by both c-myc and e2f-1  Academic Article
  • Bcl6 is required for differentiation of ig-like transcript 3-fc-induced cd8(+) t suppressor cells  Academic Article
  • Bead aggregation assays for the characterization of putative cell adhesion molecules  Academic Article
  • Beta(2)-adrenergic receptor down-regulation - evidence for a pathway that does not require endocytosis  Academic Article
  • Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3  Academic Article
  • Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells  Academic Article
  • Binding and transcriptional activation of the promoter for the neural cell-adhesion molecule by hoxc6 (hox-3.3)  Academic Article
  • Binding of recombinant feline immunodeficiency virus surface glycoprotein to feline cells: Role of cxcr4, cell-surface heparans, and an unidentified non-cxcr4 receptor  Academic Article
  • Binding of the junction-resolving enzyme bacteriophage-T7 endonuclease-I to DNA - separation of binding and catalysis by mutation  Academic Article
  • Binding of β4γ5 by adenosine A1 and A2A receptors determined by stable isotope labeling with amino acids in cell culture and mass spectrometry  Academic Article
  • Biochemical characterization of the tata-binding protein-gal4 activation domain complex  Academic Article
  • Bioluminescence reporter gene imaging characterize human embryonic stem cell-derived teratoma formation  Academic Article
  • Biotechnology of beta-adrenergic receptors  Academic Article
  • Bleeding complications with the chimeric antibody to platelet glycoprotein iib/iiia integrin in patients undergoing percutaneous coronary intervention  Academic Article
  • Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry  Academic Article
  • Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase  Academic Article
  • Brassinosteroids regulate dissociation of BKI1, a negative regulator of BRI1 signaling, from the plasma membrane  Academic Article
  • C-jun causes focus formation and anchorage-independent growth in culture but is nontumorigenic  Academic Article
  • C-terminal ecfp fusion impairs synaptotagmin 1 function - crowding out synaptotagmin 1  Academic Article
  • C-terminal zinc-containing peptide required for RNA recognition by a class I tRNA synthetase  Academic Article
  • CD8αα and ‐αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I  Academic Article
  • CDK phosphorylation of Drc1 regulates DNA replication in fission yeast  Academic Article
  • Calcium channel antagonists and human immunodeficiency virus coat protein-mediated neuronal injury  Academic Article
  • Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts  Academic Article
  • Cargo delivery kinetics of cell-penetrating peptides  Academic Article
  • Cargo selection by the COPII budding machinery during export from the ER  Academic Article
  • Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: Crystal structures of abzyme 21D8  Academic Article
  • Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase  Academic Article
  • Cdk1 coordinates cell-surface growth with the cell cycle  Academic Article
  • Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1  Academic Article
  • Cell painting with an engineered EPCR to augment the protein C system  Academic Article
  • Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo  Academic Article
  • Cell-free production of biologically active polypeptides: application to the synthesis of antibacterial peptide cecropin  Academic Article
  • Cellular function of protein phosphatase 2C in yeast  Academic Article
  • Cellular signaling by an agonist-activated receptor g(s)alpha fusion protein  Academic Article
  • Cellular translocation of proteins by transportan  Academic Article
  • Ceramide triggers budding of exosome vesicles into multivesicular endosomes  Academic Article
  • Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia  Academic Article
  • Characterization and purification of truncated human rho-kinase ii expressed in sf-21 cells  Academic Article
  • Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo  Academic Article
  • Characterization of an ig v-h idiotope that results in specific homophilic binding and increased avidity for antigen  Academic Article
  • Characterization of antibody responses to purified hiv-1 gp120 glycoproteins fused with the molecular adjuvant c3d  Academic Article
  • Characterization of multiple adhesive and counteradhesive domains in the extracellular-matrix protein cytotactin  Academic Article
  • Characterization of stable, soluble trimers containing complete ectodomains of human immunodeficiency virus type 1 envelope glycoproteins  Academic Article
  • Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli  Academic Article
  • Characterization of the iron-sulfur cluster coordinated by a cysteine cluster motif (cxxcxxxcx27c) in the nqo3 subunit in the proton-translocating nadh-quinone oxidoreductase (ndh-1) of thermus thermophilus hb-8  Academic Article
  • Characterization of the membrane domain nqo11 subunit of the proton-translocating nadh-quinone oxidoreductase of paracoccus denitrificans  Academic Article
  • Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1  Academic Article
  • Characterization of the structure and function of a novel map kinase kinase (mkk6)  Academic Article
  • Chemically regulated zinc finger transcription factors  Academic Article
  • Chemistry for the analysis of protein-protein interactions: Rapid and efficient cross-linking triggered by long wavelength light  Academic Article
  • Chimeragenesis of distantly-related proteins by noncontiguous recombination  Academic Article
  • Chimeras of herpes simplex viral vp16 and jun are oncogenic  Academic Article
  • Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins  Academic Article
  • Chimeric TALE recombinases with programmable DNA sequence specificity  Academic Article
  • Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes  Academic Article
  • Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66 receptor family selected for species cross-reactivity with an improved phage display vector  Academic Article
  • Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy  Academic Article
  • Chimeric tumor necrosis factor receptors with constitutive signaling activity  Academic Article
  • Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice  Academic Article
  • Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB  Academic Article
  • Circadian clock mutants in Arabidopsis identified by luciferase imaging  Academic Article
  • Circadian clock- and phytochrome-regulated transcription is conferred by a 78 bp cis-acting domain of the Arabidopsis CAB2 promoter  Academic Article
  • Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design  Academic Article
  • Cloning and in vivo and in vitro regulation of cyclic AMP-dependent carbon starvation genes from Escherichia coli  Academic Article
  • Cloning of a novel alpha-2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups  Academic Article
  • Cloning of rat 92-kda type iv collagenase and expression of an active recombinant catalytic domain  Academic Article
  • Cloning, expression, and characterization of human apolipoprotein(a) kringle iv37  Academic Article
  • Co-expression of ferrochelatase allows for complete heme incorporation into recombinant proteins produced in E. coli  Academic Article
  • Co-folding of a FliF-FliG split domain forms the basis of the MS:C ring interface within the bacterial flagellar motor  Academic Article
  • Cold stress-induced protein rbm3 binds 60s ribosomal subunits, alters rnicrorna levels, and enhances global protein synthesis  Academic Article
  • Colorful virus-like particles: fluorescent protein packaging by the Qβ capsid  Academic Article
  • Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: Identification of the transmembrane domain as a site for oligomerization  Academic Article
  • Complementation of a fibre mutant adenovirus by packaging cell lines stably expressing the adenovirus type 5 fibre protein  Academic Article
  • Conformational dynamics of a membrane protein chaperone enables spatially regulated substrate capture and release  Academic Article
  • Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo  Academic Article
  • Control of the murine phosphofructokinase-a gene during muscle differentiation  Academic Article
  • Conversion of a golgi-apparatus sialyltransferase to a secretory protein by replacement of the nh2-terminal signal anchor with a signal peptide  Academic Article
  • Converting IL-15 to a superagonist by binding to soluble IL-15R alpha  Academic Article
  • Coordinated spindle assembly and orientation requires clb5p-dependent kinase in budding yeast  Academic Article
  • Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast  Academic Article
  • Correlation of farnesoid x receptor coactivator recruitment and cholesterol 7 alpha-hydroxylase gene repression by bile acids  Academic Article
  • Counteraction of HLA-C-mediated immune control of HIV-1 by Nef  Academic Article
  • Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel  Academic Article
  • Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif  Academic Article
  • Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis  Academic Article
  • Crystal structure of a cocaine-binding antibody  Academic Article
  • Crystal structure of a lipid G protein-coupled receptor  Academic Article
  • Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution  Academic Article
  • Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3  Academic Article
  • Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping  Academic Article
  • Crystal structure of the C-terminal domain of mouse TLR9  Academic Article
  • Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran  Academic Article
  • Crystal structure of the oligomeric form of Lassa virus matrix protein Z  Academic Article
  • Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic e. Coil and enteropathogenic y. Pseudotuberculosis  Academic Article
  • Crystallization of HLA-DR4 fused to an immunodominant collagen ll peptide implicated in rheumatoid arthritis  Academic Article
  • Cta1-dd adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization  Academic Article
  • Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins  Academic Article
  • Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1-mediated transcription  Academic Article
  • Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1)  Academic Article
  • Cytoplasmic domain-mediated dimerizations of toll-like receptor 4 observed by beta-lactamase enzyme fragment complementation  Academic Article
  • DNA binding fluorescent proteins for the direct visualization of large DNA molecules  Academic Article
  • DNA vaccination can break immunological tolerance to prp in wild-type mice and attenuates prion disease after intracerebral challenge  Academic Article
  • De-etiolated 1 and damaged DNA binding protein 1 interact to regulate Arabidopsis photomorphogenesis  Academic Article
  • Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function  Academic Article
  • Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome  Academic Article
  • Definition of a nonlinear conformational epitope for the apolipoprotein b-100-specific monoclonal-antibody, mb47  Academic Article
  • Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes  Academic Article
  • Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a  Academic Article
  • Design and evolution of new catalytic activity with an existing protein scaffold  Academic Article
  • Design of chimeric peptide ligands to galanin receptors and substance P receptors  Academic Article
  • Design of high-throughput methods of protein production for structural biology  Academic Article
  • Design of polydactyl zinc-finger proteins for unique addressing within complex genomes  Academic Article
  • Design of two chimaeric human-rat class alpha glutathione transferases for probing the contribution of C-terminal segments of protein structure to the catalytic properties  Academic Article
  • Detection and typing of herpes simplex viruses by using recombinant immunoglobulin fragments produced in bacteria  Academic Article
  • Detection of leucine-independent DNA site occupancy of the yeast Leu3p transcriptional activator in vivo  Academic Article
  • Development of a small peptide tag for covalent labeling of proteins  Academic Article
  • Development of a system for the study of protein-protein interactions in planta: characterization of a TATA-box binding protein complex in Oryza sativa  Academic Article
  • Development of cowpea mosaic-virus as a high-yielding system for the presentation of foreign peptides  Academic Article
  • Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family  Academic Article
  • Differential effects of mutations in substrate recognition site 1 of cytochrome P450 2C2 on lauric acid and progesterone hydroxylation  Academic Article
  • Differential regulation of cell motility and invasion by fak  Academic Article
  • Differential requirements for ap-2 in clathrin-mediated endocytosis  Academic Article
  • Differential transmission of actin motion within focal adhesions  Academic Article
  • Differential-effects of cytotactin tenascin fusion proteins on intracellular ph and cell morphology  Academic Article
  • Dim1p is required for efficient splicing and export of mRNA encoding Lid1p, a component of the fission yeast anaphase-promoting complex  Academic Article
  • Dimerization of tissue factor supports solution-phase autoactivation of factor vii without influencing proteolytic activation of factor x  Academic Article
  • Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects  Academic Article
  • Directed evolution of an enhanced and highly efficient foki cleavage domain for zinc finger nucleases  Academic Article
  • Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase  Academic Article
  • Directed evolution of recombinase specificity by split gene reassembly  Academic Article
  • Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells  Academic Article
  • Disruption of angiogenesis by pex, a noncatalytic metalloproteinase fragment with integrin binding activity  Academic Article
  • Distribution and dynamics of gap junction channels revealed in living cells  Academic Article
  • Domain requirements for an endocytosis-independent, isoform-specific function of dynamin-2  Academic Article
  • Domains of tenascin involved in glioma migration  Academic Article
  • Dominant negative mutants of the duck hepatitis B virus core protein interfere with RNA pregenome packaging and viral DNA synthesis  Academic Article
  • Double-strand DNA breaks recruit the centromeric histone CENP-A  Academic Article
  • Downstream technique study of human tumor necrosis factor alpha and its mutant  Academic Article
  • Drug target validation: lethal infection blocked by inducible peptide  Academic Article
  • Dynamic contribution of nestin-expressing stem cells to adult neurogenesis  Academic Article
  • Dynamic, mitotic-like behavior of a bacterial protein required for accurate chromosome partitioning  Academic Article
  • Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry  Academic Article
  • Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis  Academic Article
  • Effect of amrinone on tumor necrosis factor production in endotoxic shock  Academic Article
  • Effect of replacing helical glycine residues with alanines on reversible and irreversible stability and production of aspergillus awamori glucoamylase  Academic Article
  • Effects of immortalization upon the induction of matrix metalloproteinases in rabbit synovial fibroblasts  Academic Article
  • Effects of soluble TNF receptor treatment on lipopolysaccharide-induced myocardial cytokine expression  Academic Article
  • Efficient preparation of natural and synthetic galactosides with a recombinant beta-1,4-galactosyltransferase-/udp-4 '-gal epimerase fusion protein  Academic Article
  • Electron microscopic evidence for the assembly of soluble pentameric extracellular domains of the nicotinic acetylcholine receptor  Academic Article
  • Electrophysiological and cerebrovascular effects of the α-secretase-derived form of amyloid precursor protein in young and middle-aged rats  Academic Article
  • Elimination of established murine colon carcinoma metastases by antibody-interleukin 2 fusion protein therapy  Academic Article
  • Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding  Academic Article
  • Engineering proteins that bind, move, make and break DNA  Academic Article
  • Engineering the ABA plant stress pathway for regulation of induced proximity  Academic Article
  • Engineering the melanocortin-4 receptor to control G(s) signaling in vivo  Academic Article
  • Enhanced activity of hu14.18-il2 immunocytokine against murine nxs2 neuroblastoma when combined with interleukin 2 therapy  Academic Article
  • Enhanced binding of rnap ii ctd phosphatase fcp1 to rap74 following ck2 phosphorylation  Academic Article
  • Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign  Academic Article
  • Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase  Academic Article
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  • Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor-lg fusion decoy  Academic Article
  • Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer  Academic Article
  • Promoter inhibition by DNA methylation - a reversible signal  Academic Article
  • Protection of islets by in situ peptide-mediated transduction of the I kappa B kinase inhibitor nemo-binding domain peptide  Academic Article
  • Protection of nude mice by passive immunization with a type-common human recombinant monoclonal antibody against hsv  Academic Article
  • Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1  Academic Article
  • Protective immunity against human carcinoembryonic antigen (cea) induced by an oral DNA vaccine in cea-transgenic mice  Academic Article
  • Protein affinity labeling mediated by genetically encoded peptide tags  Academic Article
  • Protein c inhibitor regulates the thrombin-thrombomodulin complex in the up- and down regulation of tafi activation  Academic Article
  • Protein cross-linking mediated by metal ion complexes  Academic Article
  • Protein folding: Protection from the outside  Academic Article
  • Protein n-arginine methylation in subcellular fractions of lymphoblastoid cells  Academic Article
  • Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe  Academic Article
  • Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins  Academic Article
  • Protein transfer of preformed MHC-peptide complexes sensitizes target cells to T cell cytolysis  Academic Article
  • Proteolytic processing of oligopeptides containing the target sequences by the recombinant tobacco vein mottling virus nia proteinase  Academic Article
  • Proteomics: where's Waldo in yeast?  Academic Article
  • Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex  Academic Article
  • Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progession  Academic Article
  • Purification and characterization of recombinant-expressed cytochrome P450 2C3 from Escherichia coli: 2C3 encodes the 6 beta-hydroxylase deficient form of P450 3b  Academic Article
  • Purification of a ras-responsive adenylyl cyclase complex from saccharomyces-cerevisiae by use of an epitope addition method  Academic Article
  • Purification, characterization, assembly and crystallization of assembled alfalfa mosaic virus coat protein expressed in escherichia coli  Academic Article
  • Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability  Academic Article
  • RNA recognition by designed peptide fusion creates "artificial" tRNA synthetase  Academic Article
  • Rab1 recruitment of p115 into a cis-SNARE complex: programming budding CPOII vesicles for fusion  Academic Article
  • Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display  Academic Article
  • Rac and cdc42 induce actin polymerization and g1 cell cycle progression independently of p65(pak) and the jnk/sapk map kinase cascade  Academic Article
  • Rapid activation of astrocyte-specific expression of gfap-lacz transgene by focal injury  Academic Article
  • Rapid assay of phage-derived recombinant human Fabs as bispecific antibodies  Academic Article
  • Rapid purification, site-directed mutagenesis, and initial characterization of recombinant rc3 neurogranin  Academic Article
  • Rapid, combinatorial analysis of membrane compartments in intact plants with a multicolor marker set  Academic Article
  • Rational design and expression of a heparin-targeted human superoxide-dismutase  Academic Article
  • Rational design of CXCR4 specific antibodies with elongated CDRs  Academic Article
  • Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAF(II)250  Academic Article
  • Reactivity of primary biliary-cirrhosis sera with a human-fetal liver cdna clone of branched-chain alpha-keto acid dehydrogenase dihydrolipoamide acyltransferase, the 52 kd mitochondrial auto-antigen  Academic Article
  • Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2  Academic Article
  • Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: Implication for developing subunit vaccine  Academic Article
  • Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase  Academic Article
  • Recombinant antibody fusion proteins for cancer immunotherapy  Academic Article
  • Recombinant expression of tlr5 proteins by ligand supplementation and a leucine-rich repeat hybrid technique  Academic Article
  • Recombinant expression, biochemical-characterization, and biological-activities of the human MGSA-gro protein  Academic Article
  • Recombinant full-length murine prion protein, mprp(23-231): Purification and spectroscopic characterization  Academic Article
  • Recombinant rabbit fab with binding activity to type-1 plasminogen activator inhibitor derived from a phage-display library against human alpha-granules  Academic Article
  • Recruitment of a 19s proteasome subcomplex to an activated promoter  Academic Article
  • Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation  Academic Article
  • Redirecting effector T cells through their IL-2 receptors  Academic Article
  • Redundant and distinct functions for dynamin-1 and dynamin-2 isoforms  Academic Article
  • Regulated expression of alpha-2,6-sialyltransferase by the liver-enriched transcription factors hnf-1, dbp, and lap  Academic Article
  • Regulation of Pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor  Academic Article
  • Regulation of Rho GTPases by crosstalk and neuronal activity in vivo  Academic Article
  • Regulation of STAT1 nuclear export by Jak1  Academic Article
  • Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca(2+)/calmodulin-dependent protein kinases type I, II, and IV  Academic Article
  • Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors  Academic Article
  • Regulation of flowering time in Arabidopsis by K homology domain proteins  Academic Article
  • Regulation of mOAT-mediated organic anion transport by okadaic acid and protein kinase C in LLC-PK1 cells  Academic Article
  • Regulation of mitotic inhibitor Mik1 helps to enforce the DNA damage checkpoint  Academic Article
  • Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1  Academic Article
  • Regulation of plasminogen gene expression by interleukin-6  Academic Article
  • Regulation of sod genes in escherichia-coli - relevance to superoxide-dismutase function  Academic Article
  • Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor  Academic Article
  • Relationship of the human-immunodeficiency-virus type-1 gp120 3rd variable loop to a component of the cd4 binding-site in the 4th conserved region  Academic Article
  • Removal of impurities from transcription factor preparations that alter their DNA-binding properties  Academic Article
  • Replication checkpoint enforced by kinases Cds1 and Chk1  Academic Article
  • Rescuing an essential enzyme-RNA complex with a non-essential appended domain  Academic Article
  • Retinoblastoma gene-product activates expression of the human TGF-beta-2 gene through transcription factor ATF-2  Academic Article
  • Reversible labeling of native and fusion-protein motifs  Academic Article
  • Reversible silencing of enhancers by sequences derived from the human ifn-alpha promoter  Academic Article
  • Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity  Academic Article
  • Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo  Academic Article
  • Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission  Academic Article
  • Role of Rab9 GTPase in facilitating receptor recruitment by TIP47  Academic Article
  • Role of secondary structure in discrimination between constitutive and inducible activators  Academic Article
  • Rotenone-insensitive internal nadh-quinone oxidoreductase of saccharomyces cerevisiae mitochondria: The enzyme expressed in escherichia coli acts as a member of the respiratory chain in the host cells  Academic Article
  • Rrna-complementarity in the 5 ' untranslated region of mrna specifying the gtx homeodomain protein: Evidence that base-pairing to 18s rrna affects translational efficiency  Academic Article
  • S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells  Academic Article
  • SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation  Academic Article
  • SV40 T-antigen abrogates p53-mediated transcriptional activity  Academic Article
  • Secreted CXCL12 (SDF-1) forms dimers under physiological conditions  Academic Article
  • Selection and application of peptide-binding peptides  Academic Article
  • Selection of drug-resistant feline immunodeficiency virus (FIV) encoding FIV/HIV chimeric protease in the presence of HIV-specific protease inhibitors  Academic Article
  • Selection of human antihapten antibodies from semisynthetic libraries  Academic Article
  • Selection of phage-displayed superantigen by binding to cell-surface mhc class ii  Academic Article
  • Selective binding of ligands to beta-1, beta-2 or chimeric beta-1-beta-2-adrenergic receptors involves multiple subsites  Academic Article
  • Selective interaction of a conformationally-constrained Arg-Gly-Asp (RGD) motif with the integrin receptor alpha v beta 3 expressed on human tumor cells  Academic Article
  • Selective recognition of oligomeric hiv-1 primary isolate envelope glycoprotelins by potently neutralizing ligands requires efficient precursor cleavage  Academic Article
  • Separate cell-binding sites within cytotactin tenascin differentially promote neurite outgrowth  Academic Article
  • Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast  Academic Article
  • Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family  Academic Article
  • Sh3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation  Academic Article
  • Signaling antibodies complexed with adenovirus circumvent car and integrin interactions and improve gene delivery  Academic Article
  • Silencing of HIV-1 subtype C primary isolates by expressed small hairpin RNAs targeted to gag  Academic Article
  • Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis  Academic Article
  • Site-selective cleavage of structured RNA by a Staphylococcal nuclease DNA hybrid  Academic Article
  • Sjögren's syndrome nuclear antigen B (La): cDNA cloning, structural domains, and autoepitopes  Academic Article
  • Small interfering RNA-induced transcriptional gene silencing in human cells  Academic Article
  • Soluble expression, purification, and characterization of recombinant human flotillin-2 (reggie-1) in Escherichia coli  Academic Article
  • Solution structure by 2D 1H-NMR of a chimeric peptide recognized by galanin and neuropeptide Y receptors  Academic Article
  • Solution-NMR characterization of outer-membrane protein A from E. coli in lipid bilayer nanodiscs and detergent micelles  Academic Article
  • Species barrier to RNA recognition overcome with nonspecific RNA binding domains  Academic Article
  • Spine-type-specific recruitment of newly synthesized AMPA receptors with learning  Academic Article
  • Sre1, an iron-modulated gata DNA-binding protein of iron-uptake genes in the fungal pathogen histoplasma capsulatum  Academic Article
  • Stability and conformation of a chemoreceptor HAMP domain chimera correlates with signaling properties  Academic Article
  • Stable transduction of the interleukin-2 gene into human natural killer cell lines and their phenotypic and functional characterization in vitro and in vivo  Academic Article
  • Strategies for the purification and on-column cleavage of glutathione-s-transferase fusion target proteins  Academic Article
  • Stress-activated protein kinase pathway in cell cycle control of fission yeast  Academic Article
  • Structural analysis of a fiber-pseudotyped adenovirus with ocular tropism suggests differential modes of cell receptor interactions  Academic Article
  • Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex  Academic Article
  • Structural and kinetic evidence for strain in biological catalysis  Academic Article
  • Structural basis for allosteric regulation of GPCRs by sodium ions  Academic Article
  • Structural basis for double-stranded RNA processing by Dicer  Academic Article
  • Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus  Academic Article
  • Structural origins of efficient proton abstraction from carbon by a catalytic antibody  Academic Article
  • Structural requirement for autoreactivity on human pyruvate dehydrogenase-e2, the major autoantigen of primary biliary-cirrhosis - implication for a conformational autoepitope  Academic Article
  • Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors  Academic Article
  • Structure and functional role of dynein's microtubule-binding domain  Academic Article
  • Structure of Thermotoga maritima TM0439: Implications for the mechanism of bacterial GntR transcription regulators with Zn(2+)-binding FCD domains  Academic Article
  • Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies  Academic Article
  • Structure of botulinurn neurotoxin type d light chain at 1.65 Å resolution: Repercussions for vamp-2 substrate specificity  Academic Article
  • Structure of cardiac gap junction intercellular channels  Academic Article
  • Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway  Academic Article
  • Structure, lipid scrambling activity and role in autophagosome formation of ATG9A  Academic Article
  • Structure-based design of peptide presentation on a viral surface: The crystal structure of a plant/animal virus chimera at 2.8 Å resolution  Academic Article
  • Subdomain chimeras of hepatic lipase and lipoprotein lipase - localization of heparin and cofactor binding  Academic Article
  • Surface display of proteins on bacteriophage lambda heads  Academic Article
  • Surface mobility of postsynaptic AMPARs tunes synaptic transmission  Academic Article
  • Surrobodies with functional tails  Academic Article
  • Survey of immune-related, mannose/fucose-binding c-type lectin receptors reveals widely divergent sugar-binding specificities  Academic Article
  • Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1  Academic Article
  • Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies  Academic Article
  • Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons  Academic Article
  • Syndecan-fc hybrid molecule as a potent in vitro microbicidal anti-hiv-1 agent  Academic Article
  • Synergy between an antiangiogenic integrin alpha(v) antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases  Academic Article
  • Synthesis of programmable integrases  Academic Article
  • Synthesis of two polypeptide subunits of an aminoacyl tRNA synthetase as a single polypeptide chain  Academic Article
  • Synthesis, cloning and expression in Escherichia coli of artificial genes coding for biologically active elongated precursors of the vasoactive intestinal polypeptide  Academic Article
  • T cell memory against colon carcinoma is long-lived absence of antigen  Academic Article
  • T-cell antigen receptor-binding sites for the microbial superantigen staphylococcal enterotoxin-a  Academic Article
  • TCR-mediated internalization of peptide-MHC complexes acquired by T cells  Academic Article
  • TORCS: Transducers of regulated CREB activity  Academic Article
  • TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion  Academic Article
  • TRP channels and thermosensation  Academic Article
  • Tak1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide  Academic Article
  • Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51  Academic Article
  • Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme  Academic Article
  • Targeted gene deletion of miRNAs in mice by TALEN system  Academic Article
  • Targeted gene knockout by direct delivery of zinc-finger nuclease proteins  Academic Article
  • Targeted interleukin 2 therapy enhances protective immunity induced by an autologous oral DNA vaccine against murine melanoma  Academic Article
  • Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase  Academic Article
  • Targeting malignant B cells with an immunotoxin against ROR1  Academic Article
  • Targeting murine immune responses to selected T cell- or antibody-defined determinants of the hepatitis B surface antigen by plasmid DNA vaccines encoding chimeric antigen  Academic Article
  • Targeting of lymphotoxin-alpha to the tumor elicits an efficient immune response associated with induction of peripheral lymphoid-like tissue  Academic Article
  • Targeting of t lymphocytes to melanoma cells through chimeric anti-gd3 immunoglobulin t-cell receptors  Academic Article
  • Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake  Academic Article
  • The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein  Academic Article
  • The Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism  Academic Article
  • The AviD-tag, a NeutrAvidin/avidin specific peptide affinity tag for the immobilization and purification of recombinant proteins  Academic Article
  • The NMR solution conformation of unligated human cyclophilin A  Academic Article
  • The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins  Academic Article
  • The activity-dependent histone variant H2BE modulates the life span of olfactory neurons  Academic Article
  • The alpha-helical rod domain of human lamins A and C contains a chromatin binding site  Academic Article
  • The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50  Academic Article
  • The c-terminal region of cellular qin oligomerizes: Correlation with oncogenic transformation and transcriptional repression  Academic Article
  • The cation-π interaction enables a Halo-tag fluorogenic probe for fast no-wash live cell imaging and gel-free protein quantification  Academic Article
  • The cbp/p300 taz1 domain in its native state is not a binding partner of mdm2  Academic Article
  • The ch14.18-gm-csf fusion protein is effective at mediating antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity in vitro  Academic Article
  • The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation  Academic Article
  • The crystal structure of the human DNA repair endonuclease hap1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites  Academic Article
  • The cytoplasmic tail of nsp4, the endoplasmic reticulum-localized non-structural glycoprotein of rotavirus, contains distinct virus binding and coiled coil domains  Academic Article
  • The dangers of splicing and dicing - on the use of chimeric transcriptional activators in-vitro  Academic Article
  • The ermC leader peptide: amino acid alterations leading to differential efficiency of induction by macrolide-lincosamide-streptogramin B antibiotics  Academic Article
  • The geminivirus nuclear shuttle protein is a virulence factor that suppresses transmembrane receptor kinase activity  Academic Article
  • The high activity of rat glutathione transferase 8-8 with alkene substrates is dependent on a glycine residue in the active site  Academic Article
  • The histidine-221 to tyrosine substitution in v-mos abolishes its biological function and its protein-kinase activity  Academic Article
  • The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells  Academic Article
  • The human beta-3-adrenergic receptor is resistant to short-term agonist-promoted desensitization  Academic Article
  • The human d-1a dopamine receptor: Heterologous expression in saccharomyces cerevisiae and purification of the functional receptor  Academic Article
  • The influence of various insect cell lines, p10 and polyhedrin promoters in the production of secreted insulin-like growth factor-interleukin-3 chimeras in the baculovirus expression system  Academic Article
  • The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin cd151  Academic Article
  • The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas  Academic Article
  • The inv(16) cooperates with arf haploinsufficiency to induce acute myeloid leukemia  Academic Article
  • The kringle V-protease domain is a fibrinogen binding region within apo(a)  Academic Article
  • The level of mhc class i expression on murine adenocarcinoma can change the antitumor effector mechanism of immunocytokine therapy  Academic Article
  • The major nuclear envelope targeting domain of lap2 coincides with its lamin binding region but is distinct from its chromatin interaction domain  Academic Article
  • The maltose-binding protein as a scaffold for monovalent display of peptides derived from phage libraries  Academic Article
  • The mammalian guanine nucleotide exchange factor mSec12 is essential for activation of the Sar1 GTPase directing endoplasmic reticulum export  Academic Article
  • The modular character of a DNA junction-resolving enzyme - a zinc-binding motif in bacteriophage-T4 endonuclease-VII  Academic Article
  • The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity  Academic Article
  • The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway  Academic Article
  • The ornithine decarboxylase gene is a transcriptional target of c-myc  Academic Article
  • The regulation of circadian period by phototransduction pathways in Arabidopsis  Academic Article
  • The retinoblastoma-susceptibility gene-product binds directly to the human tata-binding protein-associated factor taf(ii)250  Academic Article
  • The role of Tyr13 and Lys15 of interleukin-8 in the high affinity interaction with the interleukin-8 receptor type A  Academic Article
  • The role of arginine-143 in the electrostatics and mechanism of Cu,Zn superoxide-dismutase - computational and experimental evaluation by mutational analysis  Academic Article
  • The role of microtubule-associated protein 2c in the reorganization of microtubules and lamellipodia during neurite initiation  Academic Article
  • The role of protein s in the activation of thrombin activatable fibrinolysis inhibitor (tafi) and regulation of fibrinolysis  Academic Article
  • The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor  Academic Article
  • The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERR alpha)  Academic Article
  • The transition-state transcription regulator abrb of bacillus-subtilis is autoregulated during vegetative growth  Academic Article
  • The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase  Academic Article
  • Therapeutic efficacy of tumor-targeted il2 in lt alpha(-/-) mice depends on conditioned t cells  Academic Article
  • Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands  Academic Article
  • Tom40 protein import channel binds to non-native proteins and prevents their aggregation  Academic Article
  • Tomato bushy stunt virus (TBSV), a versatile platform for polyvalent display of antigenic epitopes and vaccine design  Academic Article
  • Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta(3) subunit  Academic Article
  • Toward synthetic transcription activators: Recruitment of transcription factors to DNA by a pna-peptide chimera  Academic Article
  • Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export  Academic Article
  • Tpr-mediated interaction of rapc with coma inhibits response regulator-DNA binding for competence development in bacillus subtilis  Academic Article
  • Trans-complementation rescue of cyclophilin A-deficient viruses reveals that the requirement for cyclophilin A in human immunodeficiency virus type 1 replication is independent of its isomerase activity  Academic Article
  • Transcription activating property of autoantigen SG2NA and modulating effect of WD-40 repeats  Academic Article
  • Transcription activation by a pna-peptide chimera in a mammalian cell extract  Academic Article
  • Transcriptional regulation of the mouse fatty acid amide hydrolase gene  Academic Article
  • Transduction of dendritic cells with adenoviral vectors encoding ctla4-ig markedly reduces their allostimulatory activity  Academic Article
  • Transferable domain in the g(1) cyclin cln2 sufficient to switch degradation of sic1 from the e3 ubiquitin ligase scfcdc4 to scfgrr1  Academic Article
  • Transgenic expression of ifn-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration  Academic Article
  • Transgenic mice containing a human heavy-chain immunoglobulin gene fragment cloned in a yeast artificial chromosome  Academic Article
  • Translational control mediated by UA-rich sequences  Academic Article
  • Transmembrane peptides stabilize inverted cubic phases in a biphasic length-dependent manner: Implications for protein-induced membrane fusion  Academic Article
  • Transthyretin slowly exchanges subunits under physiological conditions: A convenient chromatographic method to study subunit exchange in oligomeric proteins  Academic Article
  • Treatment of murine lupus with cDNA encoding IFN-gamma R/Fc  Academic Article
  • Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes  Academic Article
  • Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin  Academic Article
  • Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease  Academic Article
  • Tumor-targeted il-2 amplifies t cell-mediated immune response induced by gene therapy with single-chain il-12  Academic Article
  • Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis  Academic Article
  • Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA  Academic Article
  • Two- and three-dimensional live cell imaging of DNA damage response proteins  Academic Article
  • Tyrosine phosphorylation of ionotropic glutamate receptors by fyn or src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and psd-95  Academic Article
  • Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry  Academic Article
  • UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin  Academic Article
  • Uba domains of DNA damage-inducible proteins interact with ubiquitin  Academic Article
  • Ubiquitin ligase activity of tfiih and the transcriptional response to DNA damage  Academic Article
  • Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates  Academic Article
  • Unc93b1 biases toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against rna-sensing  Academic Article
  • Uncoupling of transfer of the presequence and unfolding of the mature domain in precursor translocation across the mitochondrial outer membrane  Academic Article
  • Universal caging group for the in-cell detection of glutathione transferase applied to 19F NMR and bioluminogenic probes  Academic Article
  • Uracil DNA N-glycosylase promotes assembly of human centromere protein A  Academic Article
  • Use of a peptide mimotope to guide the humanization of MRK-16, an anti-P-glycoprotein monoclonal antibody  Academic Article
  • Use of chimeras generated by DNA shuffling: Probing structure-function relationships among glutathione transferases  Academic Article
  • Use of phage display and transition-state analogs to select enzyme variants with altered catalytic properties: Glutathione transferase as an example  Academic Article
  • Using small molecules to improve generation of induced pluripotent stem cells from somatic cells  Academic Article
  • Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: Murine alpha 8 beta 1 binds to the rgd site in tenascin-c fragments, but not to native tenascin-c  Academic Article
  • Vaccinia virus utilizes microtubules for movement to the cell surface  Academic Article
  • Versatile strategy for controlling the specificity and activity of engineered T cells  Academic Article
  • Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease  Academic Article
  • Viruses can silently prime for and trigger central nervous system autoimmune disease  Academic Article
  • Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes  Academic Article
  • Xiap induces nf-kappa b activation via the bir1/tab1 interaction and bir1 dimerization  Academic Article
  • Yy1 binding to a subset of p53 DNA-target sites regulates p53-dependent transcription  Academic Article
  • Zinc-dependent tRNA binding by a peptide element within a tRNA synthetase  Academic Article
  • [Ca2+]i elevation and oxidative stress induce KCNQ1 protein translocation from the cytosol to the cell surface and increase slow delayed rectifier (IKs) in cardiac myocytes  Academic Article
  • eCD4-Ig variants that more potently neutralize HIV-1  Academic Article
  • plusTipTracker: Quantitative image analysis software for the measurement of microtubule dynamics  Academic Article
  • tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity  Academic Article

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