subject area of

• 4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms  Academic Article
• A CCHC metal-binding domain in Nanos is essential for translational regulation  Academic Article
• A P element with a novel fusion of reporters identifies regular, a C2H2 zinc-finger gene downstream of the circadian clock  Academic Article
• A binding site for homeodomain and pax proteins is necessary for l1 cell adhesion molecule gene expression by pax-6 and bone morphogenetic proteins  Academic Article
• A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding  Academic Article
• A chimeric hiv-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (gm-csf) domain induces enhanced antibody and t cell responses  Academic Article
• A chromatin binding-site in the tail domain of nuclear lamins that interacts with core histones  Academic Article
• A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease  Academic Article
• A conformational transition at the n terminus of the prion protein features in formation of the scrapie isoform  Academic Article
• A conserved MutS homolog connector domain interface interacts with MutL homologs  Academic Article
• A critical role for tyrosine residues in his(6)ni-mediated protein cross-linking  Academic Article
• A di-acidic signal required for selective export from the endoplasmic reticulum  Academic Article
• A dimerization "switch" in the internalization mechanism of a cell-penetrating peptide  Academic Article
• A disease-specific measure of health-related quality of life in adults with chronic immune thrombocytopenic purpura: Psychometric testing in an open-label clinical trial  Academic Article
• A dual-function DNA vaccine encoding carcinoembryonic antigen and cd40 ligand trimer induces t cell-mediated protective immunity against colon cancer in carcinoembryonic antigen-transgenic mice  Academic Article
• A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol)  Academic Article
• A functional interaction between RIP140 and PGC-1 alpha regulates the expression of the lipid droplet protein CIDEA  Academic Article
• A fusion protein system for the recombinant production of short disulfide-containing peptides  Academic Article
• A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain  Academic Article
• A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly  Academic Article
• A general strategy for the bacterial expression of amyloidogenic peptides using BCL-XL-1/2 fusions  Academic Article
• A general system for evaluating the efficiency of chromophore-assisted light inactivation (CALI) of proteins reveals Ru(ii) tris-bipyridyl as an unusually efficient "warhead"  Academic Article
• A genetic analysis of pax3-fkhr, the oncogene of alveolar rhabdomyosarcoma  Academic Article
• A gfp-equipped bidirectional expression module well suited for monitoring tetracycline-regulated gene expression in mouse  Academic Article
• A global metabolite profiling approach to identify protein-metabolite interactions  Academic Article
• A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs  Academic Article
• A hingeless Fc fusion system for site-specific cleavage by IdeS  Academic Article
• A maltose-binding protein fusion construct yields a robust crystallography platform for MCL1  Academic Article
• A mechanism for microtubule depolymerization by kini kinesins  Academic Article
• A nanobody:GFP bacterial platform that enables functional enzyme display and easy quantification of display capacity  Academic Article
• A new functional domain of guanine nucleotide dissociation inhibitor (alpha-gdi) involved in rab recycling  Academic Article
• A new strategy for glycoprotein synthesis: ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as TEV protease cleavable fusion protein  Academic Article
• A next-generation cleaved, soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies  Academic Article
• A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis  Academic Article
• A novel circadian phenotype based on firefly luciferase expression in transgenic plants  Academic Article
• A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma  Academic Article
• A novel high-affinity human monoclonal antibody to mesothelin  Academic Article
• A novel method for high-level production of TEV protease by superfolder GFP tag  Academic Article
• A novel multiple affinity purification tag and its use in identification of proteins associated with a cyclin-CDK complex  Academic Article
• A novel promoter motif for caulobacter cell cycle-controlled DNA replication genes  Academic Article
• A peptide core motif for binding to heterotrimeric G protein α subunits  Academic Article
• A plant-like kinase in plasmodium falciparum regulates parasite egress from erythrocytes  Academic Article
• A potent transactivation domain mimic with activity in living cells  Academic Article
• A proximity based general method for identification of ligand and receptor interactions in living cells  Academic Article
• A quail long-term cell-culture transformed by a chimeric jun oncogene  Academic Article
• A recombinant antibody interleukin-2 fusion protein suppresses growth of hepatic human neuroblastoma metastases in severe combined immunodeficiency mice  Academic Article
• A role for peroxisomes in photomorphogenesis and development of Arabidopsis  Academic Article
• A role for ranbp1 in the release of crm1 from the nuclear pore complex in a terminal step of nuclear export  Academic Article
• A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis  Academic Article
• A selective tumor microvasculature thrombogen that targets a novel receptor complex in the tumor angiogenic microenvironment  Academic Article
• A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth  Academic Article
• A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors  Academic Article
• A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins  Academic Article
• A soluble single-chain T-cell receptor IL-2 fusion protein retains MHC-restricted peptide specificity and IL-2 bioactivity  Academic Article
• A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle  Academic Article
• A structural role of histidine 15 in human glutathione transferase M1-1, an amino acid residue conserved in class Mu enzymes  Academic Article
• A transcriptional switch mediated by cofactor methylation  Academic Article
• A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity  Academic Article
• A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli  Academic Article
• AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation  Academic Article
• ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein  Academic Article
• Aak1-mediated mu 2 phosphorylation is stimulated by assembled clathrin  Academic Article
• Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells  Academic Article
• Activated protein C reduces graft neutrophil activation in clinical renal transplantation  Academic Article
• Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1  Academic Article
• Activation of a Ca(2+)-dependent protein kinase involves intramolecular binding of a calmodulin-like regulatory domain  Academic Article
• Activation of a beta 2-adrenergic receptor/gs alpha fusion protein elicits a desensitization-resistant camp signal capable of inhibiting proliferation of two cancer cell lines  Academic Article
• Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor vii  Academic Article
• Activation of cyclin e/cdk2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin e  Academic Article
• Activation of human effector cells by a tumor reactive recombinant anti-ganglioside gd(2) interleukin-2 fusion protein (ch14.18-il2)  Academic Article
• Activation of multidrug resistance (P-glycoprotein) mdr3/mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice  Academic Article
• Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation  Academic Article
• Activity-guided engineering of natural product carrier proteins  Academic Article
• Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells  Academic Article
• Administration of recombinant p-selectin glycoprotein ligand fc fusion protein suppresses inflammation and neointimal formation in zucker diabetic rat model  Academic Article
• Adp-ribosylation factor 4 small gtpase mediates epidermal growth factor receptor-dependent phospholipase d2 activation  Academic Article
• Affinity purification of protein complexes in C. elegans  Academic Article
• Affinity-based assay of Rho guanosine triphosphatase activation  Academic Article
• Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation  Academic Article
• Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors  Academic Article
• Allosteric modulation of ampa-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, n-cam  Academic Article
• Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system  Academic Article
• Altered trafficking of FAS and subsequent resistance to FAS-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma  Academic Article
• Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head  Academic Article
• Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome  Academic Article
• Amg 531, a thrombopoiesis-stimulating protein, for chronic itp  Academic Article
• An E. coli aminoacyl-tRNA synthetase can substitute for yeast mitochondrial enzyme function in vivo  Academic Article
• An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis  Academic Article
• An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cells  Academic Article
• An antagonist peptide epo receptor complex suggests that receptor dimerization is not sufficient for activation  Academic Article
• An antibody CDR3-erythropoietin fusion protein  Academic Article
• An antibody-interleukin 2 fusion protein overcomes tumor heterogeneity by induction of a cellular immune response  Academic Article
• An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct  Academic Article
• An efficient platform for genetic selection and screening of gene switches in Escherichia coli  Academic Article
• An efficient platform for screening expression and crystallization of glycoproteins produced in human cells  Academic Article
• An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system  Academic Article
• An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation  Academic Article
• An inhibitor of sequence-specific proteolysis that targets the substrate rather than the enzyme  Academic Article
• An ultra-high throughput cell-based screen for wee1 degradation inhibitors  Academic Article
• Analysis of bacteriophage N protein and peptide binding to boxB RNA using polyacrylamide gel coelectrophoresis (PACE)  Academic Article
• Analysis of cell-cell contact mediated by Ig superfamily cell adhesion molecules  Academic Article
• Analysis of hapten binding and catalytic determinants in a family of catalytic antibodies  Academic Article
• Analysis of nuclear protein import and export in vitro using fluorescent cargoes  Academic Article
• Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex  Academic Article
• Analysis of the epitopes of proliferating cell nuclear antigen recognized by monoclonal antibodies  Academic Article
• Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera  Academic Article
• Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis b surface antigen particles  Academic Article
• Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein  Academic Article
• Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for beta-Pix in negative regulation of focal adhesion maturation  Academic Article
• Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins  Academic Article
• Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies  Academic Article
• Antibody targeted drugs as cancer therapeutics  Academic Article
• Antibody-il-12 fusion proteins are effective in scid mouse models of prostate and colon carcinoma metastases  Academic Article
• Antibody-interleukin 2 fusion proteins: A new approach to cancer therapy  Academic Article
• Antibody-targeted interleukin-2 stimulates t-cell killing of autologous tumor-cells  Academic Article
• Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy  Academic Article
• Antigenic and immunologic characterization of an allogeneic colon carcinoma vaccine  Academic Article
• Ap-2/eps15 interaction is required for receptor-mediated endocytosis  Academic Article
• Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors  Academic Article
• Architecture of cannabinoid signaling in mouse retina  Academic Article
• Arf tumor suppressor promoter monitors latent oncogenic signals in vivo  Academic Article
• Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes  Academic Article
• Artificial oncoproteins: Modified versions of the yeast bzip protein gcn4 induce cellular transformation  Academic Article
• Assays used to study the DNA replication checkpoint in fission yeast  Academic Article
• Assembly of combinatorial antibody libraries on phage surfaces - the gene-iii site  Academic Article
• Association of ca(v)1.3 l-type calcium channels with shank  Academic Article
• Astrocyte-specific expression of hamster prion protein (prp) renders prp knockout mice susceptible to hamster scrapie  Academic Article
• Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor  Academic Article
• Attenuation of phytochrome A and B signaling pathways by the Arabidopsis circadian clock  Academic Article
• Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface  Academic Article
• BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein  Academic Article
• Bacillus subtilis hydrolyzes chey-p at the location of its action, the flagellar switch  Academic Article
• Bacterial chemoreceptor dynamics correlate with activity state and are coupled over long distances  Academic Article
• Bacterial expression of tenecin 3, an insect antifungal protein isolated from tenebrio molitor, and its efficient purification  Academic Article
• Barx2, a new homeobox gene of the bar class, is expressed in neural and craniofacial structures during development  Academic Article
• Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases  Academic Article
• Bcl-2 is an apoptotic target suppressed by both c-myc and e2f-1  Academic Article
• Bcl6 is required for differentiation of ig-like transcript 3-fc-induced cd8(+) t suppressor cells  Academic Article
• Bead aggregation assays for the characterization of putative cell adhesion molecules  Academic Article
• Beta(2)-adrenergic receptor down-regulation - evidence for a pathway that does not require endocytosis  Academic Article
• Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3  Academic Article
• Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells  Academic Article
• Binding and transcriptional activation of the promoter for the neural cell-adhesion molecule by hoxc6 (hox-3.3)  Academic Article
• Binding of recombinant feline immunodeficiency virus surface glycoprotein to feline cells: Role of cxcr4, cell-surface heparans, and an unidentified non-cxcr4 receptor  Academic Article
• Binding of the junction-resolving enzyme bacteriophage-T7 endonuclease-I to DNA - separation of binding and catalysis by mutation  Academic Article
• Binding of β4γ5 by adenosine A1 and A2A receptors determined by stable isotope labeling with amino acids in cell culture and mass spectrometry  Academic Article
• Biochemical characterization of the tata-binding protein-gal4 activation domain complex  Academic Article
• Bioluminescence reporter gene imaging characterize human embryonic stem cell-derived teratoma formation  Academic Article
• Biotechnology of beta-adrenergic receptors  Academic Article
• Bleeding complications with the chimeric antibody to platelet glycoprotein iib/iiia integrin in patients undergoing percutaneous coronary intervention  Academic Article
• Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry  Academic Article
• Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase  Academic Article
• Brassinosteroids regulate dissociation of BKI1, a negative regulator of BRI1 signaling, from the plasma membrane  Academic Article
• C-jun causes focus formation and anchorage-independent growth in culture but is nontumorigenic  Academic Article
• C-terminal ecfp fusion impairs synaptotagmin 1 function - crowding out synaptotagmin 1  Academic Article
• C-terminal zinc-containing peptide required for RNA recognition by a class I tRNA synthetase  Academic Article
• CD8αα and ‐αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I  Academic Article
• CDK phosphorylation of Drc1 regulates DNA replication in fission yeast  Academic Article
• Calcium channel antagonists and human immunodeficiency virus coat protein-mediated neuronal injury  Academic Article
• Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts  Academic Article
• Cargo delivery kinetics of cell-penetrating peptides  Academic Article
• Cargo selection by the COPII budding machinery during export from the ER  Academic Article
• Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: Crystal structures of abzyme 21D8  Academic Article
• Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase  Academic Article
• Cdk1 coordinates cell-surface growth with the cell cycle  Academic Article
• Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1  Academic Article
• Cell painting with an engineered EPCR to augment the protein C system  Academic Article
• Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo  Academic Article
• Cell-free production of biologically active polypeptides: application to the synthesis of antibacterial peptide cecropin  Academic Article
• Cellular function of protein phosphatase 2C in yeast  Academic Article
• Cellular signaling by an agonist-activated receptor g(s)alpha fusion protein  Academic Article
• Cellular translocation of proteins by transportan  Academic Article
• Ceramide triggers budding of exosome vesicles into multivesicular endosomes  Academic Article
• Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia  Academic Article
• Characterization and purification of truncated human rho-kinase ii expressed in sf-21 cells  Academic Article
• Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo  Academic Article
• Characterization of an ig v-h idiotope that results in specific homophilic binding and increased avidity for antigen  Academic Article
• Characterization of antibody responses to purified hiv-1 gp120 glycoproteins fused with the molecular adjuvant c3d  Academic Article
• Characterization of multiple adhesive and counteradhesive domains in the extracellular-matrix protein cytotactin  Academic Article
• Characterization of stable, soluble trimers containing complete ectodomains of human immunodeficiency virus type 1 envelope glycoproteins  Academic Article
• Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli  Academic Article
• Characterization of the iron-sulfur cluster coordinated by a cysteine cluster motif (cxxcxxxcx27c) in the nqo3 subunit in the proton-translocating nadh-quinone oxidoreductase (ndh-1) of thermus thermophilus hb-8  Academic Article
• Characterization of the membrane domain nqo11 subunit of the proton-translocating nadh-quinone oxidoreductase of paracoccus denitrificans  Academic Article
• Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1  Academic Article
• Characterization of the structure and function of a novel map kinase kinase (mkk6)  Academic Article
• Chemically regulated zinc finger transcription factors  Academic Article
• Chemistry for the analysis of protein-protein interactions: Rapid and efficient cross-linking triggered by long wavelength light  Academic Article
• Chimeragenesis of distantly-related proteins by noncontiguous recombination  Academic Article
• Chimeras of herpes simplex viral vp16 and jun are oncogenic  Academic Article
• Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins  Academic Article
• Chimeric TALE recombinases with programmable DNA sequence specificity  Academic Article
• Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66 receptor family selected for species cross-reactivity with an improved phage display vector  Academic Article
• Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy  Academic Article
• Chimeric tumor necrosis factor receptors with constitutive signaling activity  Academic Article
• Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice  Academic Article
• Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB  Academic Article
• Circadian clock mutants in Arabidopsis identified by luciferase imaging  Academic Article
• Circadian clock- and phytochrome-regulated transcription is conferred by a 78 bp cis-acting domain of the Arabidopsis CAB2 promoter  Academic Article
• Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design  Academic Article
• Cloning and in vivo and in vitro regulation of cyclic AMP-dependent carbon starvation genes from Escherichia coli  Academic Article
• Cloning of a novel alpha-2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups  Academic Article
• Cloning of rat 92-kda type iv collagenase and expression of an active recombinant catalytic domain  Academic Article
• Cloning, expression, and characterization of human apolipoprotein(a) kringle iv37  Academic Article
• Co-expression of ferrochelatase allows for complete heme incorporation into recombinant proteins produced in E. coli  Academic Article
• Co-folding of a FliF-FliG split domain forms the basis of the MS:C ring interface within the bacterial flagellar motor  Academic Article
• Cold stress-induced protein rbm3 binds 60s ribosomal subunits, alters rnicrorna levels, and enhances global protein synthesis  Academic Article
• Colorful virus-like particles: fluorescent protein packaging by the Qβ capsid  Academic Article
• Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: Identification of the transmembrane domain as a site for oligomerization  Academic Article
• Complementation of a fibre mutant adenovirus by packaging cell lines stably expressing the adenovirus type 5 fibre protein  Academic Article
• Conformational dynamics of a membrane protein chaperone enables spatially regulated substrate capture and release  Academic Article
• Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo  Academic Article
• Control of the murine phosphofructokinase-a gene during muscle differentiation  Academic Article
• Conversion of a golgi-apparatus sialyltransferase to a secretory protein by replacement of the nh2-terminal signal anchor with a signal peptide  Academic Article
• Converting IL-15 to a superagonist by binding to soluble IL-15R alpha  Academic Article
• Coordinated spindle assembly and orientation requires clb5p-dependent kinase in budding yeast  Academic Article
• Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast  Academic Article
• Correlation of farnesoid x receptor coactivator recruitment and cholesterol 7 alpha-hydroxylase gene repression by bile acids  Academic Article
• Counteraction of HLA-C-mediated immune control of HIV-1 by Nef  Academic Article
• Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel  Academic Article
• Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif  Academic Article
• Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis  Academic Article
• Crystal structure of a cocaine-binding antibody  Academic Article
• Crystal structure of a lipid G protein-coupled receptor  Academic Article
• Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution  Academic Article
• Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3  Academic Article
• Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping  Academic Article
• Crystal structure of the C-terminal domain of mouse TLR9  Academic Article
• Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran  Academic Article
• Crystal structure of the oligomeric form of Lassa virus matrix protein Z  Academic Article
• Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic e. Coil and enteropathogenic y. Pseudotuberculosis  Academic Article
• Crystallization of HLA-DR4 fused to an immunodominant collagen ll peptide implicated in rheumatoid arthritis  Academic Article
• Cta1-dd adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization  Academic Article
• Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins  Academic Article
• Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1-mediated transcription  Academic Article
• Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1)  Academic Article
• Cytoplasmic domain-mediated dimerizations of toll-like receptor 4 observed by beta-lactamase enzyme fragment complementation  Academic Article
• DNA binding fluorescent proteins for the direct visualization of large DNA molecules  Academic Article
• DNA vaccination can break immunological tolerance to prp in wild-type mice and attenuates prion disease after intracerebral challenge  Academic Article
• De-etiolated 1 and damaged DNA binding protein 1 interact to regulate Arabidopsis photomorphogenesis  Academic Article
• Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function  Academic Article
• Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome  Academic Article
• Definition of a nonlinear conformational epitope for the apolipoprotein b-100-specific monoclonal-antibody, mb47  Academic Article
• Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes  Academic Article
• Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a  Academic Article
• Design and evolution of new catalytic activity with an existing protein scaffold  Academic Article
• Design of chimeric peptide ligands to galanin receptors and substance P receptors  Academic Article
• Design of high-throughput methods of protein production for structural biology  Academic Article
• Design of polydactyl zinc-finger proteins for unique addressing within complex genomes  Academic Article
• Design of two chimaeric human-rat class alpha glutathione transferases for probing the contribution of C-terminal segments of protein structure to the catalytic properties  Academic Article
• Detection and typing of herpes simplex viruses by using recombinant immunoglobulin fragments produced in bacteria  Academic Article
• Detection of leucine-independent DNA site occupancy of the yeast Leu3p transcriptional activator in vivo  Academic Article
• Development of a small peptide tag for covalent labeling of proteins  Academic Article
• Development of a system for the study of protein-protein interactions in planta: characterization of a TATA-box binding protein complex in Oryza sativa  Academic Article
• Development of cowpea mosaic-virus as a high-yielding system for the presentation of foreign peptides  Academic Article
• Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family  Academic Article
• Differential effects of mutations in substrate recognition site 1 of cytochrome P450 2C2 on lauric acid and progesterone hydroxylation  Academic Article
• Differential regulation of cell motility and invasion by fak  Academic Article
• Differential requirements for ap-2 in clathrin-mediated endocytosis  Academic Article
• Differential transmission of actin motion within focal adhesions  Academic Article
• Differential-effects of cytotactin tenascin fusion proteins on intracellular ph and cell morphology  Academic Article
• Dim1p is required for efficient splicing and export of mRNA encoding Lid1p, a component of the fission yeast anaphase-promoting complex  Academic Article
• Dimerization of tissue factor supports solution-phase autoactivation of factor vii without influencing proteolytic activation of factor x  Academic Article
• Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects  Academic Article
• Directed evolution of an enhanced and highly efficient foki cleavage domain for zinc finger nucleases  Academic Article
• Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase  Academic Article
• Directed evolution of recombinase specificity by split gene reassembly  Academic Article
• Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells  Academic Article
• Disruption of angiogenesis by pex, a noncatalytic metalloproteinase fragment with integrin binding activity  Academic Article
• Distribution and dynamics of gap junction channels revealed in living cells  Academic Article
• Domain requirements for an endocytosis-independent, isoform-specific function of dynamin-2  Academic Article
• Domains of tenascin involved in glioma migration  Academic Article
• Dominant negative mutants of the duck hepatitis B virus core protein interfere with RNA pregenome packaging and viral DNA synthesis  Academic Article
• Double-strand DNA breaks recruit the centromeric histone CENP-A  Academic Article
• Downstream technique study of human tumor necrosis factor alpha and its mutant  Academic Article
• Drug target validation: lethal infection blocked by inducible peptide  Academic Article
• Dynamic contribution of nestin-expressing stem cells to adult neurogenesis  Academic Article
• Dynamic, mitotic-like behavior of a bacterial protein required for accurate chromosome partitioning  Academic Article
• Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry  Academic Article
• Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis  Academic Article
• Effect of amrinone on tumor necrosis factor production in endotoxic shock  Academic Article
• Effect of replacing helical glycine residues with alanines on reversible and irreversible stability and production of aspergillus awamori glucoamylase  Academic Article
• Effects of immortalization upon the induction of matrix metalloproteinases in rabbit synovial fibroblasts  Academic Article
• Effects of soluble TNF receptor treatment on lipopolysaccharide-induced myocardial cytokine expression  Academic Article
• Efficient preparation of natural and synthetic galactosides with a recombinant beta-1,4-galactosyltransferase-/udp-4 '-gal epimerase fusion protein  Academic Article
• Electron microscopic evidence for the assembly of soluble pentameric extracellular domains of the nicotinic acetylcholine receptor  Academic Article
• Electrophysiological and cerebrovascular effects of the α-secretase-derived form of amyloid precursor protein in young and middle-aged rats  Academic Article
• Elimination of established murine colon carcinoma metastases by antibody-interleukin 2 fusion protein therapy  Academic Article
• Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding  Academic Article
• Engineering proteins that bind, move, make and break DNA  Academic Article
• Engineering the ABA plant stress pathway for regulation of induced proximity  Academic Article
• Engineering the melanocortin-4 receptor to control G(s) signaling in vivo  Academic Article
• Enhanced activity of hu14.18-il2 immunocytokine against murine nxs2 neuroblastoma when combined with interleukin 2 therapy  Academic Article
• Enhanced binding of rnap ii ctd phosphatase fcp1 to rap74 following ck2 phosphorylation  Academic Article
• Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign  Academic Article
• Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase  Academic Article
• Enzyme treatment-free and ligation-independent cloning using caged primers in polymerase chain reactions  Academic Article
• Eradication of human hepatic and pulmonary melanoma metastases in scid mice by antibody-interleukin 2 fusion proteins  Academic Article
• Erythropoietin receptor activation by a ligand-induced conformation change  Academic Article
• Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins  Academic Article
• Evaluation of transportan 10 in PEI mediated plasmid delivery assay  Academic Article
• Evidence for two modes of cooperative DNA binding in vivo that do not involve direct protein-protein interactions  Academic Article
• Evidence that ga111 protein is a target of the ga14 activation domain in the mediator  Academic Article
• Evolution of programmable zinc finger-recombinases with activity in human cells  Academic Article
• Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network  Academic Article
• Exploring the membrane domain of the reduced nicotinamide adenine dinucleotide-quinone oxidoreductase of paracoccus denitrificans: Characterization of the nqo7 subunit  Academic Article
• Expression and characterization of a humanized cocaine-binding antibody  Academic Article
• Expression and characterization of the Neurospora crassa endoglucanase GH5-1  Academic Article
• Expression and characterization of von Willebrand factor dimerization defects in different types of von Willebrand disease  Academic Article
• Expression and purification of recombinant his(6)-tagged guanine-nucleotide dissociation inhibitor and formation of its rab1 complex  Academic Article
• Expression of a TNF inhibitor in transgenic mice  Academic Article
• Expression of an animal virus antigenic site on the surface of a plant-virus particle  Academic Article
• Expression of antibody Fab fragments and whole immunoglobulin in mammalian cells  Academic Article
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• Human CD8 transgene regulation of HLA recognition by murine T cells  Academic Article
• Human Mus81-associated endonuclease cleaves Holliday junctions in vitro  Academic Article
• Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15  Academic Article
• Human antibody effector function  Academic Article
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• Immunomodulation by adenoviral-mediated SCD40-Ig gene therapy for mouse allogeneic islet transplantation  Academic Article
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• Kinetic mechanism for p38 map kinase  Academic Article
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• Making chemistry selectable by linking it to infectivity  Academic Article
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• Measuring the hierarchy of molecular events during clathrin-mediated endocytosis  Academic Article
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• Rapid, combinatorial analysis of membrane compartments in intact plants with a multicolor marker set  Academic Article
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• Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation  Academic Article
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• Surrobodies with functional tails  Academic Article
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• Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons  Academic Article
• Syndecan-fc hybrid molecule as a potent in vitro microbicidal anti-hiv-1 agent  Academic Article
• Synergy between an antiangiogenic integrin alpha(v) antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases  Academic Article
• Synthesis of programmable integrases  Academic Article
• Synthesis of two polypeptide subunits of an aminoacyl tRNA synthetase as a single polypeptide chain  Academic Article
• Synthesis, cloning and expression in Escherichia coli of artificial genes coding for biologically active elongated precursors of the vasoactive intestinal polypeptide  Academic Article
• T cell memory against colon carcinoma is long-lived absence of antigen  Academic Article
• T-cell antigen receptor-binding sites for the microbial superantigen staphylococcal enterotoxin-a  Academic Article
• TCR-mediated internalization of peptide-MHC complexes acquired by T cells  Academic Article
• TORCS: Transducers of regulated CREB activity  Academic Article
• TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion  Academic Article
• TRP channels and thermosensation  Academic Article
• Tak1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide  Academic Article
• Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51  Academic Article
• Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme  Academic Article
• Targeted gene deletion of miRNAs in mice by TALEN system  Academic Article
• Targeted gene knockout by direct delivery of zinc-finger nuclease proteins  Academic Article
• Targeted interleukin 2 therapy enhances protective immunity induced by an autologous oral DNA vaccine against murine melanoma  Academic Article
• Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase  Academic Article
• Targeting malignant B cells with an immunotoxin against ROR1  Academic Article
• Targeting murine immune responses to selected T cell- or antibody-defined determinants of the hepatitis B surface antigen by plasmid DNA vaccines encoding chimeric antigen  Academic Article
• Targeting of lymphotoxin-alpha to the tumor elicits an efficient immune response associated with induction of peripheral lymphoid-like tissue  Academic Article
• Targeting of t lymphocytes to melanoma cells through chimeric anti-gd3 immunoglobulin t-cell receptors  Academic Article
• Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake  Academic Article
• The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein  Academic Article
• The Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism  Academic Article
• The AviD-tag, a NeutrAvidin/avidin specific peptide affinity tag for the immobilization and purification of recombinant proteins  Academic Article
• The NMR solution conformation of unligated human cyclophilin A  Academic Article
• The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins  Academic Article
• The activity-dependent histone variant H2BE modulates the life span of olfactory neurons  Academic Article
• The alpha-helical rod domain of human lamins A and C contains a chromatin binding site  Academic Article
• The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50  Academic Article
• The c-terminal region of cellular qin oligomerizes: Correlation with oncogenic transformation and transcriptional repression  Academic Article
• The cation-π interaction enables a Halo-tag fluorogenic probe for fast no-wash live cell imaging and gel-free protein quantification  Academic Article
• The cbp/p300 taz1 domain in its native state is not a binding partner of mdm2  Academic Article
• The ch14.18-gm-csf fusion protein is effective at mediating antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity in vitro  Academic Article
• The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation  Academic Article
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• The cytoplasmic tail of nsp4, the endoplasmic reticulum-localized non-structural glycoprotein of rotavirus, contains distinct virus binding and coiled coil domains  Academic Article
• The dangers of splicing and dicing - on the use of chimeric transcriptional activators in-vitro  Academic Article
• The ermC leader peptide: amino acid alterations leading to differential efficiency of induction by macrolide-lincosamide-streptogramin B antibiotics  Academic Article
• The geminivirus nuclear shuttle protein is a virulence factor that suppresses transmembrane receptor kinase activity  Academic Article
• The high activity of rat glutathione transferase 8-8 with alkene substrates is dependent on a glycine residue in the active site  Academic Article
• The histidine-221 to tyrosine substitution in v-mos abolishes its biological function and its protein-kinase activity  Academic Article
• The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells  Academic Article
• The human beta-3-adrenergic receptor is resistant to short-term agonist-promoted desensitization  Academic Article
• The human d-1a dopamine receptor: Heterologous expression in saccharomyces cerevisiae and purification of the functional receptor  Academic Article
• The influence of various insect cell lines, p10 and polyhedrin promoters in the production of secreted insulin-like growth factor-interleukin-3 chimeras in the baculovirus expression system  Academic Article
• The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin cd151  Academic Article
• The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas  Academic Article
• The inv(16) cooperates with arf haploinsufficiency to induce acute myeloid leukemia  Academic Article
• The kringle V-protease domain is a fibrinogen binding region within apo(a)  Academic Article
• The level of mhc class i expression on murine adenocarcinoma can change the antitumor effector mechanism of immunocytokine therapy  Academic Article
• The major nuclear envelope targeting domain of lap2 coincides with its lamin binding region but is distinct from its chromatin interaction domain  Academic Article
• The maltose-binding protein as a scaffold for monovalent display of peptides derived from phage libraries  Academic Article
• The mammalian guanine nucleotide exchange factor mSec12 is essential for activation of the Sar1 GTPase directing endoplasmic reticulum export  Academic Article
• The modular character of a DNA junction-resolving enzyme - a zinc-binding motif in bacteriophage-T4 endonuclease-VII  Academic Article
• The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity  Academic Article
• The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway  Academic Article
• The ornithine decarboxylase gene is a transcriptional target of c-myc  Academic Article
• The regulation of circadian period by phototransduction pathways in Arabidopsis  Academic Article
• The retinoblastoma-susceptibility gene-product binds directly to the human tata-binding protein-associated factor taf(ii)250  Academic Article
• The role of Tyr13 and Lys15 of interleukin-8 in the high affinity interaction with the interleukin-8 receptor type A  Academic Article
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• The role of microtubule-associated protein 2c in the reorganization of microtubules and lamellipodia during neurite initiation  Academic Article
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• The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor  Academic Article
• The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERR alpha)  Academic Article
• The transition-state transcription regulator abrb of bacillus-subtilis is autoregulated during vegetative growth  Academic Article
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• Tom40 protein import channel binds to non-native proteins and prevents their aggregation  Academic Article
• Tomato bushy stunt virus (TBSV), a versatile platform for polyvalent display of antigenic epitopes and vaccine design  Academic Article
• Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta(3) subunit  Academic Article
• Toward synthetic transcription activators: Recruitment of transcription factors to DNA by a pna-peptide chimera  Academic Article
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• Transcription activating property of autoantigen SG2NA and modulating effect of WD-40 repeats  Academic Article
• Transcription activation by a pna-peptide chimera in a mammalian cell extract  Academic Article
• Transcriptional regulation of the mouse fatty acid amide hydrolase gene  Academic Article
• Transduction of dendritic cells with adenoviral vectors encoding ctla4-ig markedly reduces their allostimulatory activity  Academic Article
• Transferable domain in the g(1) cyclin cln2 sufficient to switch degradation of sic1 from the e3 ubiquitin ligase scfcdc4 to scfgrr1  Academic Article
• Transgenic expression of ifn-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration  Academic Article
• Transgenic mice containing a human heavy-chain immunoglobulin gene fragment cloned in a yeast artificial chromosome  Academic Article
• Translational control mediated by UA-rich sequences  Academic Article
• Transmembrane peptides stabilize inverted cubic phases in a biphasic length-dependent manner: Implications for protein-induced membrane fusion  Academic Article
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• Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes  Academic Article
• Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin  Academic Article
• Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease  Academic Article
• Tumor-targeted il-2 amplifies t cell-mediated immune response induced by gene therapy with single-chain il-12  Academic Article
• Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis  Academic Article
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• Two- and three-dimensional live cell imaging of DNA damage response proteins  Academic Article
• Tyrosine phosphorylation of ionotropic glutamate receptors by fyn or src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and psd-95  Academic Article
• Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry  Academic Article
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• Uba domains of DNA damage-inducible proteins interact with ubiquitin  Academic Article
• Ubiquitin ligase activity of tfiih and the transcriptional response to DNA damage  Academic Article
• Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates  Academic Article
• Unc93b1 biases toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against rna-sensing  Academic Article
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• Universal caging group for the in-cell detection of glutathione transferase applied to 19F NMR and bioluminogenic probes  Academic Article
• Uracil DNA N-glycosylase promotes assembly of human centromere protein A  Academic Article
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• Use of phage display and transition-state analogs to select enzyme variants with altered catalytic properties: Glutathione transferase as an example  Academic Article
• Using small molecules to improve generation of induced pluripotent stem cells from somatic cells  Academic Article
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• Viruses can silently prime for and trigger central nervous system autoimmune disease  Academic Article
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