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Pyridazines

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  • A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties  Academic Article
  • Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474  Academic Article
  • Blocking of fatty acid amide hydrolase activity with PF-04457845 in human brain: a positron emission tomography study with the novel radioligand [(11)C]CURB  Academic Article
  • Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)  Academic Article
  • Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators  Academic Article
  • Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase  Academic Article
  • Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino) cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methano ne, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile  Academic Article
  • Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia  Academic Article
  • Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound  Academic Article
  • Discovery of pyrrolo 1,2-b pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors  Academic Article
  • Gaba(a) receptor antagonism in the extended amygdala decreases ethanol self-administration in rats  Academic Article
  • Mechanistic and pharmacological characterization of PF-04457845: A highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain  Academic Article
  • Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase  Academic Article
  • Nadh-quinone oxidoreductase: Psst subunit couples electron transfer from iron-sulfur cluster n2 to quinone  Academic Article
  • Pancreas-specific delivery of β-cell proliferating small molecules  Academic Article
  • Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals  Academic Article
  • Radical-based regioselective C-H functionalization of electron-deficient heteroarenes: scope, tunability, and predictability  Academic Article
  • Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors  Academic Article
  • SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists  Academic Article
  • Signals from chloroplasts converge to regulate nuclear gene expression  Academic Article
  • Synthesis of pyridazine-based scaffolds as alpha-helix mimetics  Academic Article
  • The synthesis and in vivo evaluation of F-18 PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)  Academic Article

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