Mutation

subject area of

"Resistance" to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 do not confer resistance Academic Article
'Late onset' ornithine transcarbamylase deficiency: function of three purified recombinant mutant enzymes Academic Article
3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting Academic Article
5' cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved 5' GU Academic Article
A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2 Academic Article
A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon Academic Article
A CCHC metal-binding domain in Nanos is essential for translational regulation Academic Article
A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response Academic Article
A Saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability Academic Article
A THEMIS:SHP1 complex promotes T-cell survival Academic Article
A bacterial amber suppressor in Saccharomyces cerevisiae is selectively recognized by a bacterial aminoacyl-tRNA synthetase Academic Article
A base change in the catalytic core of the hairpin ribozyme perturbs function but not domain docking Academic Article
A base triple in the tetrahymena group i core affects the reaction equilibrium via a threshold effect Academic Article
A c-alpha model for the transmembrane alpha helices of gap junction intercellular channels Academic Article
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Academic Article
A cell cycle phosphoproteome of the yeast centrosome Academic Article
A cell-autonomous requirement for the cell cycle regulatory protein, rb, in neuronal migration Academic Article
A cell-cycle checkpoint monitors cell morphogenesis in budding yeast Academic Article
A chemical chaperone decouples TDP-43 disordered domain phase separation from fibrillation Academic Article
A chemical toolkit for proteins: an expanded genetic code Academic Article
A chiroselective peptide replicator Academic Article
A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease Academic Article
A clonal analysis of tergite development in Drosophila of ultraabdominal and paradoxical genotypes Academic Article
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells Academic Article
A conservative isoleucine to leucine mutation causes major rearrangements and cold sensitivity in KlenTaq1 DNA polymerase Academic Article
A conserved family of prolyl-4-hydroxylases that modify HIF Academic Article
A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins Academic Article
A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension Academic Article
A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function Academic Article
A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development Academic Article
A covering method for detecting genetic associations between rare variants and common phenotypes Academic Article
A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells Academic Article
A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics Academic Article
A crucial role for the putative Arabidopsis topoisomerase VI in plant growth and development Academic Article
A de novo designed peptide ligase: A mechanistic investigation Academic Article
A de novo protein binding pair by computational design and directed evolution Academic Article
A designed inhibitor of a CLC antiporter blocks function through a unique binding mode Academic Article
A di-acidic (DxE) code directs concentration of cargo during export from the endoplasmic reticulum Academic Article
A di-acidic signal required for selective export from the endoplasmic reticulum Academic Article
A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase Academic Article
A distinct set of drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory Academic Article
A dominant negative mutant of the E. Coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit Academic Article
A dominant-negative peroxisome proliferator-activated receptor gamma (ppar gamma) mutant is a constitutive repressor and inhibits ppar gamma-mediated adipogenesis Academic Article
A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory Academic Article
A dynamin mutant defines a superconstricted prefission state Academic Article
A family of cyclin homologs that control the g1 phase in yeast Academic Article
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity Academic Article
A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function Academic Article
A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity Academic Article
A general method for greatly improving the affinity of antibodies by using combinatorial libraries Academic Article
A general method for site-specific incorporation of unnatural amino acids into proteins Academic Article
A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers Academic Article
A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase Academic Article
A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe Academic Article
A glutamate switch controls voltage-sensitive phosphatase function Academic Article
A growth regulatory loop that provides homeostasis to phytochrome A signaling Academic Article
A guanosine to adenosine transition in the 3' terminal extracistronic region of bacteriophage Qβ RNA leading to loss of infectivity Academic Article
A helix replacement mechanism directs metavinculin functions Academic Article
A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B Academic Article
A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion Academic Article
A highly conserved neutralizing epitope on group 2 influenza a viruses Academic Article
A highly membrane-active peptide in Flock House virus: Implications for the mechanism of nodavirus infection Academic Article
A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1 Academic Article
A human germ line antibody light chain with hydrolytic properties associated with multimerization status Academic Article
A humanized anti-4-1bb monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates Academic Article
A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd Academic Article
A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses Academic Article
A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41 Academic Article
A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa Academic Article
A membrane-embedded amino acid couples the SpoIIQ channel protein to anti-sigma factor transcriptional repression during Bacillus subtilis sporulation Academic Article
A metal-binding motif implicated in RNA recognition by an aminoacyl-tRNA synthetase and by a retroviral gene product Academic Article
A method to site-specifically introduce methyllysine into proteins in E. coli Academic Article
A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron Academic Article
A missense mutation in the neutrophil cytochrome-b heavy-chain in cytochrome-positive x-linked chronic granulomatous-disease Academic Article
A molecular description of the evolution of resistance Academic Article
A molecular switch regulating transcriptional repression and activation of PPARγ Academic Article
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration Academic Article
A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks Academic Article
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response Academic Article
A mutant of rous sarcoma virus (type o) causing fusiform cell transformation Academic Article
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function Academic Article
A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome Academic Article
A mutation in the FHA domain of Coprinus cinereus Nbs1 leads to Spo11-independent meiotic recombination and chromosome segregation Academic Article
A mutation in the human cyclin-dependent kinase interacting protein, ckshs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly Academic Article
A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters Academic Article
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα Academic Article
A new regulatory switch in a JAK protein kinase Academic Article
A new strategy for the synthesis of glycoproteins Academic Article
A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis Academic Article
A note on efficient estimation of mutation-rates using luria-delbruck fluctuation analysis Academic Article
A novel GJA8 mutation (p.V44A) causing autosomal dominant congenital cataract Academic Article
A novel cross-talk in diacylglycerol signaling the rac-gap beta 2-chimaerin is negatively regulated by protein kinase c delta-mediated phosphorylation Academic Article
A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex Academic Article
A novel promoter motif for caulobacter cell cycle-controlled DNA replication genes Academic Article
A novel splice acceptor site mutation which produces multiple splicing abnormalities resulting in protein S deficiency type I Academic Article
A novel technique for the rapid preparation of mutant RNAs Academic Article
A nucleoside transporter from Trypanosoma brucei involved in drug resistance Academic Article
A p47-phox pseudogene carries the most common mutation causing p47-phox-deficient chronic granulomatous disease Academic Article
A perspective on the structural and functional constraints for immune evasion: insights from influenza virus Academic Article
A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins Academic Article
A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor Academic Article
A plasma membrane H(+)-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana Academic Article
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Academic Article
A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins Academic Article
A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.Fem-3 mRNA complex Academic Article
A putative bacterial ABC transporter circumvents the essentiality of signal peptidase Academic Article
A quick diversity-oriented amide-forming reaction to optimize p-subsite residues of hiv protease inhibitors Academic Article
A rab1 mutant affecting guanine-nucleotide exchange promotes disassembly of the golgi-apparatus Academic Article
A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin Academic Article
A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90 Academic Article
A role for brassinosteroids in light-dependent development of Arabidopsis Academic Article
A role for dual viral hits in causation of subacute sclerosing panencephalitis Academic Article
A role for flavin monooxygenase-like enzymes in auxin biosynthesis Academic Article
A role for peroxisomes in photomorphogenesis and development of Arabidopsis Academic Article
A role for the P-body component GW182 in microRNA function Academic Article
A role for the swe1 checkpoint kinase during filamentous growth of saccharomyces cerevisiae Academic Article
A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib Academic Article
A role of the kinase mtor in cellular transformation induced by the oncoproteins p3k and akt Academic Article
A selective chemical probe for coenzyme a - requiring enzymes Academic Article
A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo Academic Article
A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth Academic Article
A siglec-like sialic-acid-binding motif revealed in an adenovirus capsid protein Academic Article
A silencer element in the retinoblastoma tumor-suppressor gene Academic Article
A simple structural feature is a major determinant of the identity of a transfer RNA Academic Article
A single amino-acid change in the mouse peroxisome proliferator-activated receptor-alpha alters transcriptional responses to peroxisome proliferators Academic Article
A single base pair affects binding and catalytic parameters in the molecular recognition of a transfer RNA Academic Article
A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression Academic Article
A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouse Academic Article
A sphingosine 1-phosphate receptor 2 selective allosteric agonist Academic Article
A structural view of evolutionary divergence Academic Article
A study of genes that may modulate the expression of hereditary hemochromatosis: Transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (irp)-1 and-2, and hepcidin Academic Article
A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase Academic Article
A temperature-sensitive lesion affecting levels of transformation-specific viral RNA in a mutant of avian sarcoma virus PRCII Academic Article
A transcriptional repressor obtained by alternative translation of a trinucleotide repeat Academic Article
A two-component signal transduction system essential for growth of bacillus subtilis: Implications for anti-infective therapy Academic Article
A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5 Academic Article
A unique gtp-dependent sporulation sensor histidine kinase in bacillus anthracis Academic Article
A virus-based nanoblock with tunable electrostatic properties Academic Article
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair Academic Article
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC Academic Article
AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin Academic Article
ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization Academic Article
ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import Academic Article
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1 Academic Article
Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine Academic Article
Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells Academic Article
Accessory mutations maintain stability in drug-resistant HIV-1 protease Academic Article
Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae Academic Article
Acidic food pH increases palatability and consumption and extends drosophila lifespan Academic Article
Acidification of endosome subpopulations in wild-type chinese-hamster ovary cells and temperature-sensitive acidification-defective mutants Academic Article
Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering Academic Article
Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions Academic Article
Activated protein C resistance caused by Arg506Gln mutation in factor Va Academic Article
Activated protein C variants with normal cytoprotective but reduced anticoagulant activity Academic Article
Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe Academic Article
Activation domain-dependent monoubiquitylation of Gal4 protein is essential for promoter binding in vivo Academic Article
Activation of snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos Academic Article
Activation of tumor cell integrin alpha(v)beta(3) controls angiogenesis and metastatic growth in the brain Academic Article
Activation tagging of the floral inducer FT Academic Article
Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast Academic Article
Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein Academic Article
Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties Academic Article
Active site residues of cyclophilin A are crucial for its signaling activity via CD147 Academic Article
Active site serine promotes stabilization of the reactive glutathione thiolate in rat glutathione transferase T2-2 - Evidence against proposed sulfatase activity of the corresponding human enzyme Academic Article
Active, interactive, and inactive steroid-receptor mutants Academic Article
Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3 Academic Article
Activity of yeast extracts in cell-free stimulation of DNA-replication Academic Article
Activity-guided engineering of natural product carrier proteins Academic Article
Adaptive mutations alter antibody structure and dynamics during affinity maturation Academic Article
Adenovirus core protein pvii is translocated into the nucleus by multiple import receptor pathways Academic Article
Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by rho family gtpases Academic Article
Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice Academic Article
Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie b-adenovirus receptor-bearing cells Academic Article
Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae Academic Article
Adult chicken alpha-globin gene-expression in transfected qt6 quail cells - evidence for a negative regulatory element in the alpha-d gene region Academic Article
Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling Academic Article
Age-related somatic structural changes in the nuclear genome of human blood cells Academic Article
Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes Academic Article
Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA Academic Article
All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase Academic Article
Alloreactive T cells discriminate among a diverse set of endogenous peptides Academic Article
Alteration of bacillus-subtilis glutamine-synthetase results in overproduction of enzyme Academic Article
Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant Academic Article
Alteration of the reduction potential of the 4fe-4s (2+/+) cluster of azotobacter vinelandii ferredoxin i Academic Article
Alteration of the α-synuclein folding landscape by a mutation related to Parkinson's disease Academic Article
Alterations in the flow of one-carbon units affect kinb-dependent sporulation in bacillus subtilis Academic Article
Altered chaperone-like activity of α-crystallins promotes cataractogenesis Academic Article
Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system Academic Article
Altered mRNA binding activity and decreased translation initiation in a nuclear mutant lacking translation of the chloroplast psbA mRNA Academic Article
Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery Academic Article
Alternative mutations of a positively selected residue elicit qain or loss of functionalities in enzyme evolution Academic Article
Alternative outcomes in assembly of promoter complexes: The roles of TBP and a flexible linker in placing TFIIIB on tRNA genes Academic Article
Alternative splicing within the ligand binding domain of the human constitutive androstane receptor Academic Article
Alzheimer's Aβ peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)? Academic Article
American College of Medical Genetics consensus statement on factor V Leiden mutation testing Academic Article
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase Academic Article
Amino acid substitution at the dimeric interface of human manganese superoxide dismutase Academic Article
Amino-acid replacements that compensate for a large polypeptide deletion in an enzyme Academic Article
Aminoacyl tRNA synthetases and their connections to disease Academic Article
Aminoacyl-tRNA synthetases: general features and recognition of transfer RNAs Academic Article
Amplification, mutation and selection of catalytic RNA Academic Article
Amplification, rearrangement, and elevated expression of c-myc in the human prostatic carcinoma cell line LNCaP Academic Article
Amyloid diseases: Abnormal protein aggregation in neurodegeneration Academic Article
Amyotrophic Lateral Sclerosis Academic Article
Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase Academic Article
An Arabidopsis mutant defective in the plastid general protein import apparatus Academic Article
An Arabidopsis thaliana virescent mutant reveals a role for ClpR1 in plastid development Academic Article
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence Academic Article
An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors Academic Article
An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide Academic Article
An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway Academic Article
An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model Academic Article
An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening Academic Article
An association of candidate gene haplotypes and bleeding severity in von willebrand disease type 2a, 2b, and 2m pedigrees Academic Article
An engineered virus as a scaffold for three-dimensional self-assembly on the nanoscale Academic Article
An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes Academic Article
An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses Academic Article
An essential GTpase promotes assembly of preribosomal RNA processing complexes Academic Article
An essential g1 function for cyclin-like proteins in yeast Academic Article
An expanded eukaryotic genetic code Academic Article
An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system Academic Article
An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae Academic Article
An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5 Academic Article
An intact conformation at the tip of elongation factor G domain IV is functionally important Academic Article
An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity Academic Article
An interchromosomal gene conversion of the Drosophila dunce locus identified with restriction site polymorphisms: a potential involvement of transposable elements in gene conversion Academic Article
An intracellular signal transduction pathway between the chloroplast and nucleus is involved in de-etiolation Academic Article
An isogenic human ESC platform for functional evaluation of genome-wide-association-study-identified diabetes genes and drug discovery Academic Article
An mrna-rrna base-pairing mechanism for translation initiation in eukaryotes Academic Article
An online resource for GPCR structure determination and analysis Academic Article
An orthogonal DNA replication system in yeast Academic Article
An unexpected outcome of surface engineering an integral membrane protein: Improved crystallization of cytochrome ba(3) from thermus thermophilus Academic Article
Analysis by electron-microscopy of early simian-virus 40 rna from a tsa mutant Academic Article
Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries Academic Article
Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor Academic Article
Analysis of individual immunoglobulin-lambda light-chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center b-cell somatic mutation Academic Article
Analysis of male pheromones that accelerate female reproductive organ development Academic Article
Analysis of novel residues of class I involved in recognition by alloreactive T cells Academic Article
Analysis of rrna processing and translation in mammalian cells using a synthetic 18s rrna expression system Academic Article
Analysis of stop-gain and frameshift variants in human innate immunity genes Academic Article
Analyzing and tuning ribozyme activity by deep sequencing to modulate gene expression level in mammalian cells Academic Article
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase Academic Article
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity Academic Article
Antibodies against small nuclear ribonucleoproteins immunoprecipitate complexes containing ts110 Moloney murine sarcoma virus genomic and messenger RNAs Academic Article
Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics Academic Article
Antigen presentation and t cell development in h2-m-deficient mice Academic Article
Antigen-driven B cell differentiation in vivo Academic Article
Antigenic analyses of influenza-virus hemagglutinins with different receptor-binding specificities Academic Article
Antisense masking reveals contributions of mrna- rrna base pairing to translation of gtx and fgf2 mrnas Academic Article
Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors Academic Article
Application of site-directed mutagenesis to rna and DNA genomes Academic Article
Approaches for skeletal gene therapy Academic Article
Arabidopsis MYB30 is a direct target of BES1 and cooperates with BES1 to regulate brassinosteroid-induced gene expression Academic Article
Arabidopsis thaliana mutant that develops as a light-grown plant in the absence of light Academic Article
Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation Academic Article
Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors Academic Article
Architecture of the flagellar rotor Academic Article
Arenavirus diversity and evolution: Quasispecies in vivo Academic Article
Arenavirus extinction through lethal mutagenesis Academic Article
Aromatic residues in the C-terminal region of glutathione transferase A1-1 influence rate-determining steps in the catalytic mechanism Academic Article
Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein Academic Article
Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase Academic Article
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility Academic Article
Assembly of the covalent linkage between lipoic acid and its cognate enzymes Academic Article
Assignment of the L30-mRNA complex using selective isotopic labeling and RNA mutants Academic Article
Association between a disrupted-in-schizophrenia 1 (disc1) single nucleotide polymorphism and schizophrenia in a combined scandinavian case-control sample Academic Article
Association between thromboembolic events and the JAK2 V617F mutation in myeloproliferative neoplasms Academic Article
Association of the 2-mu-m DNA plasmid with yeast folded chromosomes Academic Article
Associations between phylogenetic clustering and HLA profile among HIV-infected individuals in San Diego, California Academic Article
Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificities Academic Article
Atl1 regulates choice between global genome and transcription-coupled repair of o-6-alkylguanines Academic Article
Atomic accuracy in predicting and designing noncanonical RNA structure Academic Article
Atomic structures of wild-type and thermostable mutant recombinant human cu,zn superoxide-dismutase Academic Article
Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex Academic Article
Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface Academic Article
Autoantibodies as reporters identifying aberrant cellular mechanisms in tumorigenesis Academic Article
Automated analysis of hypocotyl growth dynamics during shade avoidance in Arabidopsis Academic Article
Automated identification of functional dynamic contact networks from X-ray crystallography Academic Article
Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity Academic Article
Autoproteolysis in nucleoporin biogenesis Academic Article
Autoregulation of simian virus-40 gene-a by t-antigen Academic Article
Avian-sarcoma virus mutant that is temperature sensitive for virion assembly Academic Article
Avian-sarcoma virus prcii - conditional mutants temperature sensitive in the maintenance of fibroblast transformation Academic Article
Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential Academic Article
BACE1- and BACE2-expressing human cells - characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors Academic Article
BAS1: A gene regulating brassinosteroid levels and light responsiveness in Arabidopsis Academic Article
BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice Academic Article
BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation Academic Article
BIG: a calossin-like protein required for polar auxin transport in Arabidopsis Academic Article
BIN2, a new brassinosteroid-insensitive locus in Arabidopsis Academic Article
BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis Academic Article
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis Academic Article
BRANCHED1 interacts with FLOWERING LOCUS T to repress the floral transition of the axillary meristems in Arabidopsis Academic Article
BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint Academic Article
BRI1 is a critical component of a plasma-membrane receptor for plant steroids Academic Article
BRL1 and BRL3 are novel brassinosteroid receptors that function in vascular differentiation in Arabidopsis Academic Article
Bacillus subtilis chec and fliy are members of a novel class of chey-p-hydrolyzing proteins in the chemotactic signal transduction cascade Academic Article
Backbone-backbone H-bonds make context-dependent contributions to protein folding kinetics and thermodynamics: lessons from amide-to-ester mutations Academic Article
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin Academic Article
Balanced electrostatic and structural forces guide the large conformational change associated with maturation of t=4 virus Academic Article
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA Academic Article
Base pairing between hepatitis C virus RNA and 18S rRNA is required for IRES-dependent translation initiation in vivo Academic Article
Bcl-2 is an apoptotic target suppressed by both c-myc and e2f-1 Academic Article
Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis Academic Article
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3 Academic Article
Beware of multiple comparisons: A study of symptoms associated with mutations of the hfe hemochromatosis gene Academic Article
Biallelic mutations in IRF8 impair human NK cell maturation and function Academic Article
Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease Academic Article
Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome p450 46a1 unusual features and spectral response Academic Article
Binding of neural cell adhesion molecules (n-cams) to the cellular prion protein Academic Article
Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity Academic Article
Biobanking: an important resource for precision medicine in glioblastoma Academic Article
Biochemical characterization and crystal structure of a dim1 family associated protein: Dim2 Academic Article
Biochemical characterization of Arabidopsis wild-type and mutant phytochrome B holoproteins Academic Article
Biochemical characterization of the Caenorhabditis elegans FBF. CPB-1 translational regulation complex identifies conserved protein interaction hotspots Academic Article
Biochemical characterization of the tata-binding protein-gal4 activation domain complex Academic Article
Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1 Academic Article
Biochemical-characterization of the essential gtp-binding protein obg of bacillus-subtilis Academic Article
Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis Academic Article
Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants Academic Article
Biomarkers of endocannabinoid system activation in severe obesity Academic Article
Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes Academic Article
Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors Academic Article
Biosynthesis of the enediyne antitumor antibiotic c-1027 Academic Article
Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants Academic Article
Blockade of CD14 aggravates experimental shigellosis Academic Article
BluB cannibalizes flavin to form the lower ligand of vitamin B-12 Academic Article
Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of hfe, transferrin receptor 2 (tfr2), and il-6 Academic Article
Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA Academic Article
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor Academic Article
Brassinosteroid regulates cell elongation by modulating gibberellin metabolism in rice Academic Article
Brassinosteroid signaling and auxin transport are required to establish the periodic pattern of Arabidopsis shoot vascular bundles Academic Article
Brassinosteroid signaling: a paradigm for steroid hormone signaling from the cell surface Academic Article
Brassinosteroids control male fertility by regulating the expression of key genes involved in Arabidopsis anther and pollen development Academic Article
Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin Academic Article
Bromocriptine produces decreases in cocaine self-administration in the rat Academic Article
Bud6 directs sequential microtubule interactions with the bud tip and bud neck during spindle morphogenesis in saccharomyces cerevisiae Academic Article
Budding yeast centrosome duplication requires stabilization of Spc29 via Mps1-mediated phosphorylation Academic Article
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Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone Academic Article
Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion Academic Article
Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration Academic Article
Effect of correcting transferrin saturation for body mass index in HFE C282Y homozygotes Academic Article
Effect of gamma-interferon on cachectin expression by mononuclear phagocytes - reversal of the lpsd (endotoxin resistance) phenotype Academic Article
Effect of mutations at the lariat branch acceptor site on beta-globin pre-mRNA splicing in vitro Academic Article
Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza h5n1 viruses Academic Article
Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life Academic Article
Effect of stage-0 sporulation mutations on subtilisin expression Academic Article
Effect of the ubiquitous transcription factors, SP1 and MAZ, on NMDA receptor subunit type 1 (NR1) expression during neuronal differentiation Academic Article
Effect on thermostability and catalytic activity of introducing disulfide bonds into aspergillus awamori glucoamylase Academic Article
Effector-dependent conformational-changes in protein kinase-c-gamma through epitope mapping with inhibitory monoclonal-antibodies Academic Article
Effects of blocking individual maturation cleavages in murine leukemia virus gag Academic Article
Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing Academic Article
Effects of interface mutations on association modes and electron-transfer rates between proteins Academic Article
Effects of polyvalent cations on the folding of an rRNA three-way junction and binding of ribosomal protein S15 Academic Article
Effects of transition metals on nitric oxide synthase catalysis Academic Article
Effects on bacillus-subtilis of a conditional-lethal mutation in the essential gtp-binding protein obg Academic Article
Efficacy of retinoids in IKZF1-mutated BCR-ABL1 acute lymphoblastic leukemia Academic Article
Efficient induction of fibrosarcomas by v-jun requires mutations in the DNA-binding region and the transactivation domain Academic Article
Efficient t cell activation via a toll-interleukin 1 receptor-independent pathway Academic Article
Efficient transformation of chicken embryo fibroblasts by c-jun requires structural modification in coding and noncoding sequences Academic Article
Elemental concentrations in the seed of mutants and natural variants of Arabidopsis thaliana grown under varying soil conditions Academic Article
Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression Academic Article
Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice Academic Article
Elucidation of DnaE as the antibacterial target of the natural product, nargenicin Academic Article
Emergent properties of proteostasis in managing cystic fibrosis Academic Article
Endogenous plasmin converts Glu-plasminogen to Lys-plasminogen on the monocytoid cell surface Academic Article
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus Academic Article
Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling Academic Article
Engineering Upper Hinge Improves Stability and Effector Function of a Human IgG1 Academic Article
Engineering complex riboswitch regulation by dual genetic selection Academic Article
Engineering naturally occurring trans-acting non-coding RNAs to sense molecular signals Academic Article
Engineering of substrate selectivity for tissue factor.Factor viia complex signaling through protease-activated receptor 2 Academic Article
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice Academic Article
Enhanced human-type receptor binding by ferret-transmissible H5N1 with a K193T mutation Academic Article
Enhanced major histocompatibility complex class i binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide Academic Article
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response Academic Article
Enrich: software for analysis of protein function by enrichment and depletion of variants Academic Article
Enrichment of sequencing targets from the human genome by solution hybridization Academic Article
Enzymatic detoxication, conformational selection, and the role of molten globule active sites Academic Article
Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila Academic Article
Epigenetic characterization of the fmr1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile x syndrome Academic Article
Epithelial membrane protein-1 is a biomarker of gefitinib resistance Academic Article
Ermc leader peptide - amino-acid sequence critical for induction by translational attenuation Academic Article
Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein Academic Article
Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone Academic Article
Essential function in vivo for dicer-2 in host defense against rna viruses in drosophila Academic Article
Essential glycine in the proton channel of escherichia coli transhydrogenase Academic Article
Establishment of cell-lines persistently infected with foot-and-mouth-disease virus Academic Article
Ethanolamine activates a sensor histidine kinase regulating its utilization in enterococcus faecalis Academic Article
Evaluation of the potential impact of Ebola virus genomic drift on the efficacy of sequence-based candidate therapeutics Academic Article
Evasion of the p53 tumour surveillance network by tumour-derived myc mutants Academic Article
Evidence for a unique first position codon-anticodon mismatch in vivo Academic Article
Evidence for an intermediate conformational state of lacy Academic Article
Evidence for distinct locations for metal binding sites in two closely related class I tRNA synthetases Academic Article
Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase Academic Article
Evidence that spooa mutations are recessive in spooa--spooa+ merodiploid strains of bacillus-subtilis Academic Article
Evolution in vitro of an RNA enzyme with altered metal dependence Academic Article
Evolution in vitro: analysis of a lineage of ribozymes Academic Article
Evolution of CXCR4-using human immunodeficiency virus type 1 SF162 is associated with two unique envelope mutations Academic Article
Evolution of broad spectrum β-lactam resistance in an engineered metallo-β-lactamase Academic Article
Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling Academic Article
Evolution of glutathione transferases and related enzymes for the protection of cells against electrophiles Academic Article
Evolution of proteins with genetically encoded "chemical warheads" Academic Article
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template Academic Article
Evolutionary analysis of HIV-1 protease inhibitors: methods for design of inhibitors that evade resistance Academic Article
Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme Academic Article
Examination of the transcription factor NtcA-binding motif by in vitro selection of DNA sequences from a random library Academic Article
Excess of rare amino acid polymorphisms in the toll-like receptor 4 in humans Academic Article
Exon 5 encoded domain is not required for the toxic function of mutant sod1 but essential for the dismutase activity: Identification and characterization of two new sod1 mutations associated with familial amyotrophic lateral sclerosis Academic Article
Exonuclease 1-dependent and independent mismatch repair Academic Article
Expanded host cell tropism and cytopathic properties of feline immunodeficiency virus strain ppr subsequent to passage through interleukin-2-independent t cells Academic Article
Expanding the genetic code of Escherichia coli Academic Article
Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the golgi apparatus Academic Article
Expression of t-cell receptor genes in an antigen-specific hybridoma and radiation-induced variants Academic Article
Expression of the lyst(beige) mutation is atheroprotective in chow-fed apolipoprotein e-deficient mice Academic Article
Expression, two-dimensional crystallization, and electron cryo-crystallography of recombinant gap junction membrane channels Academic Article
External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification Academic Article
F-box proteins FKF1 and LKP2 act in concert with ZEITLUPE to control Arabidopsis clock progression Academic Article
FAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formation Academic Article
FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis Academic Article
FKF1F-BOX protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis Academic Article
FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development Academic Article
FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions Academic Article
Failure of hairpin-ended and nicked DNA to activate DNA-dependent protein kinase: Implications for V(D)J recombination Academic Article
Failure to cleave measles-virus fusion protein in lymphoid-cells - a possible mechanism for viral persistence in lymphocytes Academic Article
Far1 is required for posttranscriptional regulation of cln2 gene-expression in response to mating pheromone Academic Article
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation Academic Article
Fast folding mutants of the Tetrahymena group I ribozyme reveal a rugged folding energy landscape Academic Article
Fatal hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection in a patient with a novel mutation in the signaling lymphocytic activation molecule-associated protein Academic Article
Fbxw7/hcdc4 is a general tumor suppressor in human cancer Academic Article
Features of subunit nuom (nd4) in escherichia coli ndh-1 topology and implication of conserved glu(144) for coupling site 1 Academic Article
Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans Academic Article
Filopodia are required for cortical neurite initiation Academic Article
Fimbrin phosphorylation by metaphase Cdk1 regulates actin cable dynamics in budding yeast Academic Article
Fine definition of the CXCR4-binding region on the V3 loop of feline immunodeficiency virus surface glycoprotein Academic Article
Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region Academic Article
Fixation of mutations in the viral genome during an outbreak of foot-and-mouth-disease - heterogeneity and rate variations Academic Article
Flower arranging in Arabidopsis Academic Article
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells Academic Article
Fluorescence turn-on folding sensor to monitor proteome stress in live cells Academic Article
Fluorotryptophan incorporation modulates the structure and stability of transthyretin in a site-specific manner Academic Article
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing Academic Article
Folding and particle assembly are disrupted by single-point mutations near the autocatalytic cleavage site of nudaurelia capensis omega virus capsid protein Academic Article
Folding of fibroblast growth factor 1 is critical for its nonclassical release Academic Article
Formation of a chloride-conducting state in the maltose ATP-binding cassette (ABC) transporter Academic Article
Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1 Academic Article
Formation of gelsolin amyloid fibrils in the rough endoplasmic reticulum of skeletal muscle in the gelsolin mouse model of inclusion body myositis: comparative analysis to human sporadic inclusion body myositis Academic Article
Formation of trans-activation competent hiv-1 rev:Rre complexes requires the recruitment of multiple protein activation domains Academic Article
Forward genetics by sequencing EMS variation-induced inbred lines Academic Article
Fragile T-stem in disease-associated human mitochondrial tRNA sensitizes structure to local and distant mutations Academic Article
Frequency and genetic background of the position 122(val-Ile) variant transthyretin gene in the black-population Academic Article
Full-length archaeal rad51 structure and mutants: Mechanisms for rad51 assembly and control by brca2 Academic Article
Function of the activated protein c (apc) autolysis loop in activated fviii inactivation Academic Article
Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase Academic Article
Functional characterization of multiple DICER1 mutations in an adolescent Academic Article
Functional characterization of ttnd and ttnf, unveiling new insights into tautomycetin biosynthesis Academic Article
Functional defects of pathogenic human mitochondrial tRNAs related to structural fragility Academic Article
Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3 Academic Article
Functional roles of four conserved charged residues in the membrane domain subunit nuoa of the proton-translocating nadh-quinone oxidoreductase from escherichia coli Academic Article
Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex Academic Article
Functional-analysis of the human tissue factor promoter and induction by serum Academic Article
Functionally diverging molecular quasi-species evolve by crossing two enzymes Academic Article
Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor Academic Article
Further evidence for association of grk3 to bipolar disorder suggests a second disease mutation Academic Article
Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein e2c direct integration of viral DNA into specific sites Academic Article
G-protein mutations that alter the pheromone response in saccharomyces-cerevisiae Academic Article
GIGANTEA directly activates Flowering Locus T in Arabidopsis thaliana Academic Article
GTPase traffic control Academic Article
GUN4, a regulator of chlorophyll synthesis and intracellular signaling Academic Article
Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B Academic Article
Gain-of-function mutational activation of human tRNA synthetase procytokine Academic Article
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis Academic Article
Galactolipid deficiency and abnormal chloroplast development in the Arabidopsis MGD synthase 1 mutant Academic Article
Galanin overexpressing transgenic mice Academic Article
Gap junction channel structure in the early 21st century: Facts and fantasies Academic Article
Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles Academic Article
Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR) Academic Article
Gene therapy for chronic viral hepatitis: ribozymes, antisense oligonucleotides, and dominant negative mutants Academic Article
Gene-enzyme relationships of aromatic acid biosynthesis in bacillus-subtilis Academic Article
Generation of a Ni(II) binding site by introduction of a histidine cluster in the structure of human glutathione transferase A1-1 Academic Article
Generation of a catalytic antibody by site-directed mutagenesis Academic Article
Generation of a catalytic sequence-specific hybrid DNase Academic Article
Generation of a hybrid sequence-specific single-stranded deoxyribonuclease Academic Article
Generation of mutation hotspots in ageing bacterial colonies Academic Article
Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration Academic Article
Genetic ablation of a mouse gene expressed specifically in brain Academic Article
Genetic abnormalities and juvenile hemochromatosis: Mutations of the hjv gene encoding hemojuvelin Academic Article
Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines Academic Article
Genetic analysis of cyclic nucleotide phosphodiesterases in Drosophila melanogaster Academic Article
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large Academic Article
Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles Academic Article
Genetic analysis of innate immunity: Identification and function of the tir adapter proteins Academic Article
Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV) Academic Article
Genetic analysis of pleiotropic negative sporulation mutants in bacillus subtilis Academic Article
Genetic analysis of resistance to viral infection Academic Article
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis Academic Article
Genetic and biochemical characterization of mutants of bacillus-subtilis defective in succinate dehydrogenase Academic Article
Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development Academic Article
Genetic basis of tetrodotoxin resistance in pufferfishes Academic Article
Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases Academic Article
Genetic disorders associated with atp binding cassette cholesterol transporters Academic Article
Genetic dissection of innate immunity to infection: The mouse cytomegalovirus model Academic Article
Genetic diversity of EBV-encoded LMP1 in the Swiss HIV Cohort Study and implication for NF-Κb activation Academic Article
Genetic incorporation of histidine derivatives using an engineered pyrrolysyl-tRNA synthetase Academic Article
Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis Academic Article
Genetic interaction landscape reveals critical requirements for Schizosaccharomyces pombe Brc1 in DNA damage response mutants Academic Article
Genetic interactions between phytochrome A, phytochrome B, and cryptochrome 1 during Arabidopsis development Academic Article
Genetic localization and molecular characterization of the nons gene required for macrotetrolide biosynthesis in streptomyces griseus dsm40695 Academic Article
Genetic mutations in ten unrelated american patients with symptomatic type-1 protein-C deficiency Academic Article
Genetic recombinants and heterozygotes derived from endogenous and exogenous avian RNA tumor viruses Academic Article
Genetic screening for low-penetrance variants in protein-coding genes Academic Article
Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300 Academic Article
Genetic variation in an individual human exome Academic Article
Genetic-analysis in bacillus-subtilis Academic Article
Genetic-analysis of a class of polymyxin resistant partial revertants of stage-o sporulation mutants of bacillus-subtilis - map of the chromosome region near the origin of replication Academic Article
Genetic-mapping of a linked cluster of ribosomal ribonucleic-acid genes in bacillus-subtilis Academic Article
Genetically engineered polymers of human Cu Zn superoxide-dismutase - biochemistry and serum half-lives Academic Article
Genetics of alpha-ketoglutarate dehydrogenase complex of bacillus-subtilis Academic Article
Genetics of bacillus-subtilis chemotaxis - isolation and mapping of mutations and cloning of chemotaxis genes Academic Article
Genetics of bacterial sporulation Academic Article
Genome-wide association study identifies five new schizophrenia loci Academic Article
Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior Academic Article
Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome Academic Article
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma Academic Article
Genomic sequence of the dax1 gene: An orphan nuclear receptor responsible for x-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism Academic Article
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak Academic Article
Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila Academic Article
Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates alzheimer's disease-related neuropathies: Involvement of non-amyloidogenic processing Academic Article
Global aggregation of newly translated proteins in an Escherichia coli strain deficient of the chaperonin GroEL Academic Article
Global analysis of protein palmitoylation in yeast Academic Article
Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer Academic Article
Glutathione precursors replenish decreased glutathione pool in cystinotic cell lines Academic Article
Glutathione transferase A1-1: catalytic importance of arginine 15 Academic Article
Glutathione transferase P1-1 expression in human melanoma metastases: correlation to N-RAS mutations and expression Academic Article
Glutathione transferases with novel active sites isolated by phage display from a library of random mutants Academic Article
Glycine substitutions in collagen heterotrimers alter triple helical assembly Academic Article
Glycolipids of chick-embryo fibroblasts infected with temperature-sensitive mutants of avian-sarcoma viruses Academic Article
Glycoproteins of plasma-membrane of dictyostelium discoideum during development Academic Article
Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts Academic Article
Growth-related alterations induced in chick embryo fibroblasts by src-gene deletion mutants of the schmidt-ruppin strain of rous sarcoma virus Academic Article
H-nox-mediated nitric oxide sensing modulates symbiotic colonization by vibrio fischeri Academic Article
H7N9 influenza virus neutralizing antibodies that possess few somatic mutations Academic Article
HCV core residues critical for infectivity are also involved in core-NS5A complex formation Academic Article
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogene Academic Article
HIV-1 entry and macrophage inflammatory protein-1 beta-mediated signaling are independent functions of the chemokine receptor CCR5 Academic Article
Haematological effects of the c282yhfe mutation in homozygous and heterozygous states among subjects of northern and southern european ancestry Academic Article
Haemolytic onset of Wilson disease in a patient with homozygous truncation of ATP7B at Arg1319 Academic Article
Haptoglobin polymorphism and iron homeostasis Academic Article
Harmonin mutations cause mechanotransduction defects in cochlear hair cells Academic Article
Hcdc4 gene mutations in endometrial cancer Academic Article
Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores Academic Article
Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli Academic Article
Helical crystallization on lipid nanotubes: Streptavidin as a model protein Academic Article
Helical crystallization on nickel–lipid nanotubes: Perfringolysin O as a model protein Academic Article
Helical domain and kinase domain mutations in p110 alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms Academic Article
Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins b cell linker protein and slp-76 in lymphocytes Academic Article
Heme synthesis by plastid ferrochelatase I regulates nuclear gene expression in plants Academic Article
Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection Academic Article
Hepatitis B virus mutants: clinical significance for diagnosis and therapy Academic Article
Heregulin-ErbB3-driven tumor growth persists in PI3 kinase mutant cancer cells Academic Article
Herpes simplex virus encephalitis in human unc-93b deficiency Academic Article
Herpesviruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract Academic Article
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High prion and prpsc levels but delayed-onset of disease in scrapie-inoculated mice heterozygous for a disrupted prp gene Academic Article
High-resolution definition of vaccine-elicited b cell responses against the hiv primary receptor binding site Academic Article
High-resolution mapping of the folding transition state of a WW domain Academic Article
High-resolution mutational profiling suggests the genetic validity of glioblastoma patient-derived pre-clinical models Academic Article
High-resolution structure of a protein spin-label in a solvent-exposed β-sheet and comparison with DEER spectroscopy Academic Article
High-throughput screening methodology for the directed evolution of glycosyltransferases Academic Article
High-yield reassortant influenza vaccine production virus has a mutation at an hla-a 2.1-restricted cd8(+) ctl epitope on the ns1 protein Academic Article
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast Academic Article
Histone H3 Thr 45 phosphorylation is a replication-associated post-translational modification in S. cerevisiae Academic Article
Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast Academic Article
Histone H3 lysine 56 acetylation and the response to DNA replication fork damage Academic Article
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription Academic Article
Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of alpha 1-antitrypsin deficiency Academic Article
Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana Academic Article
Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks Academic Article
Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast Academic Article
Hiv-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins Academic Article
Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix Academic Article
Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation Academic Article
Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS Academic Article
How a mutation that slows aging can Also disproportionately extend end-of-life decrepitude Academic Article
Hsc70 is required for endocytosis and clathrin function in drosophila Academic Article
Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex Academic Article
Human NK cell deficiency as a result of biallelic mutations in MCM10 Academic Article
Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe Academic Article
Human f-box protein hcdc4 targets cyclin e for proteolysis and is mutated in a breast cancer cell line Academic Article
Human fc-gamma-ri and fc-gamma-rii interact with distinct but overlapping sites on human-igg Academic Article
Human germline antibody gene segments encode polyspecific antibodies Academic Article
Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2 Academic Article
Human immunodeficiency virus type 1 coreceptor switching: V1/V2 gain-of-fitness mutations compensate for V3 loss-of-fitness mutations Academic Article
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations Academic Article
Human protein n-terminal acetyltransferase hnaa50p (hnat5/hsan) follows ordered sequential catalytic mechanism combined kinetic and NMR study Academic Article
Human rhinovirus capsid dynamics is controlled by canyon flexibility Academic Article
Human, viral or mutant human il-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis Academic Article
Humanized IgG(1) variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates Academic Article
Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease Academic Article
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant Academic Article
Hyperglycosylated mutants of human immunodeficiency virus (hiv) type 1 monomeric gp120 as novel antigens for hiv vaccine design Academic Article
Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype Academic Article
Hyperprotease-producing mutants of bacillus subtilis Academic Article
Hypocretins/orexins as integrators of physiological information: Lessons from mutant animals Academic Article
Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner Academic Article
IRhom2 is required for the secretion of mouse TNFα Academic Article
Icosahedral virus particles as addressable nanoscale building blocks Academic Article
Identification and characterization of a novel cell-penetrating peptide Academic Article
Identification and characterization of single chain anti-cocaine catalytic antibodies Academic Article
Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor Academic Article
Identification of Asp(174) and Asp(175) as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants Academic Article
Identification of Ppk26, a DEG/ENaC channel functioning with Ppk1 in a mutually dependent manner to guide locomotion behavior in Drosophila Academic Article
Identification of a cdk-activating kinase in fission yeast Academic Article
Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor Academic Article
Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast Academic Article
Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor Academic Article
Identification of alk as a major familial neuroblastoma predisposition gene Academic Article
Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and lassa fever virus Academic Article
Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus Academic Article
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Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine Academic Article
Identification of four novel mutations in F5 associated with congenital factor V deficiency Academic Article
Identification of genes controlling growth polarity in the budding yeast saccharomyces cerevisiae: A possible role of n-glycosylation and involvement of the exocyst complex Academic Article
Identification of ginsenoside interaction sites in 5-ht3a receptors Academic Article
Identification of lps2 as a key transducer of myd88-independent tir signalling Academic Article
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Identification of pathways controlling DNA damage induced mutation in saccharomyces cerevisiae Academic Article
Identification of rare cancer driver mutations by network reconstruction Academic Article
Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor viia Academic Article
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Identification of the transcriptional suppressor sof-1 as an alteration in the spo0a protein Academic Article
Identification of the zinc ligands in cobalamin-independent methionine synthase (MetE) from Escherichia coli Academic Article
Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding Academic Article
Identification of viral mutants by mass spectrometry Academic Article
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Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases Academic Article
Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor Academic Article
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In vivo molecular evolution reveals biophysical origins of organismal fitness Academic Article
In vivo selection for the directed evolution of l-rhamnulose aldolase from l-rhamnulose-1-phosphate aldolase (rhad) Academic Article
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Interaction of the Bacillus stearothermophilus ribosomal protein S15 with its 5 '-translational operator mRNA Academic Article
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Interactions between hy1 and gun mutants of Arabidopsis, and their implications for plastid/nuclear signalling Academic Article
Intercellular coupling confers robustness against mutations in the SCN circadian clock network Academic Article
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Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants Academic Article
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Jun inhibits myogenic differentiation Academic Article
Jun, the oncoprotein Academic Article
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Kinetic intermediates trapped by native interactions in RNA folding Academic Article
Kinetic properties of missense mutations in patients with glutathione synthetase deficiency Academic Article
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Kinetics of hairpin ribozyme cleavage in yeast Academic Article
Kinetochore biorientation in Saccharomyces cerevisiae requires a tightly folded conformation of the Ndc80 complex Academic Article
Knock-in mice reveal nonsense-mediated mRNA decay in the brain Academic Article
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Label transfer chemistry for the characterization of protein-protein interactions Academic Article
Lac repressor genetic map in real space Academic Article
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Light activation of the LOV protein Vivid generates a rapidly exchanging dimer Academic Article
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Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway Academic Article
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Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase Academic Article
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Long-term persistent vesicular stomatitis-virus and rabies virus-infection of cells in vitro Academic Article
Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts Academic Article
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Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease Academic Article
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Lpr t-cell hyporesponsiveness to mitogens linked to deficient receptor-stimulated phosphoinositide hydrolysis Academic Article
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Maintenance of genome stability in Saccharomyces cerevisiae Academic Article
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Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck Academic Article
Map2 and tau bind longitudinally along the outer ridges of microtubule protofilaments Academic Article
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Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade Academic Article
Measuring food intake and nutrient absorption in Caenorhabditis elegans Academic Article
Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, polynucleotide kinase Academic Article
Mechanism of activation of protein kinase JAK2 by the growth hormone receptor Academic Article
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Mechanism-based post-translational modification and inactivation in terpene synthases Academic Article
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Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase Academic Article
Mechanistic properties of immunoglobulin somatic mutation Academic Article
Melanopsin-encoded response properties of intrinsically photosensitive retinal ganglion cells Academic Article
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Metal-binding 'finger' structures in the glucocorticoid receptor defined by site-directed mutagenesis Academic Article
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Microbial source tracking by DNA sequence analysis of the Escherichia coli malate dehydrogenase gene Academic Article
Microdroplet-based pcr enrichment for large-scale targeted sequencing Academic Article
Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features Academic Article
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Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients Academic Article
Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication Academic Article
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Mitotic misregulation and human aging Academic Article
Mitotic role for the cdc28-protein kinase of saccharomyces-cerevisiae Academic Article
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Modeling the inhibition of quadruple mutant Plasmodium falciparum dihydrofolate reductase by pyrimethamine derivatives Academic Article
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Molecular characterization of single memory b-cells Academic Article
Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions Academic Article
Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo - Rab-independent binding to membranes and role of Rab recycling factors Academic Article
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Molecular evolution of the Rab-escort-protein/guanine-nucleotide-dissociation-inhibitor superfamily Academic Article
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Molecular genetics of transmissible spongiform encephalopathies Academic Article
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Molecular methods for isolation of signal transduction pathway mutants Academic Article
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Molecular-biology approaches to genetic-defects of the mammalian nervous-system Academic Article
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Multidimensional epistasis and fitness landscapes in enzyme evolution Academic Article
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Multiple topogenic sequences in bovine opsin Academic Article
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Mushroom bodies and Drosophila learning Academic Article
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Mutagenesis of mouse myeloma cells with Melphalan Academic Article
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Mutational analysis of ligand-binding activity of beta-2 adrenergic-receptor expressed in escherichia-coli Academic Article
Mutational analysis of membrane and soluble forms of human md-2 Academic Article
Mutational analysis of phosphodiesterase in Drosophila Academic Article
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Mutational isolation of a sieve for editing in a transfer RNA synthetase Academic Article
Mutational separation of aminoacylation and cytokine activities of human tyrosyl-tRNA synthetase Academic Article
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Mutations in GNAL: a novel cause of craniocervical dystonia Academic Article
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Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells Academic Article
Mutations in cell-division cycle genes cdc36 and cdc39 activate the saccharomyces-cerevisiae mating pheromone response pathway Academic Article
Mutations in human dynamin block an intermediate stage in coated vesicle formation Academic Article
Mutations in the hfe gene and cardiovascular disease risk an individual patient data meta-analysis of 53 880 subjects Academic Article
Mutations in the regulatory domain of phenylalanine hydroxylase and response to tetrahydrobiopterin Academic Article
Mutations that affect dimer formation and helicase activity of the hepatitis C virus helicase Academic Article
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Myc rescue of a mutant csf-1 receptor impaired in mitogenic signaling Academic Article
Myc signaling via the arf tumor suppressor regulates p53-dependent apoptosis and immortalization Academic Article
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Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 map kinase Academic Article
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N-glycosylation is essential for vesicular targeting of synaptotagmin 1 Academic Article
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Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells Academic Article
Naturally death-resistant precursor cells revealed as the origin of retinoblastoma Academic Article
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair Academic Article
Negative regulation of g(1) and g(2) by s-phase cyclins of saccharomyces cerevisine Academic Article
Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2 Academic Article
Negative regulation of human c-fos expression by the retinoblastoma gene-product Academic Article
Negative regulation of yeast Eps15-like Arp2/3 complex activator, Pan1p, by the Hip1R-related protein, Sla2p, during endocytosis Academic Article
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Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases Academic Article
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity Academic Article
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New Arabidopsis cue mutants suggest a close connection between plastid- and phytochrome regulation of nuclear gene expression Academic Article
New addresses on an addressable virus nanoblock: Uniquely reactive lys residues on cowpea mosaic virus Academic Article
New cluster of ribosomal genes in bacillus-subtilis with regulatory role in sporulation Academic Article
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix Academic Article
New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: analysis of the epidermal growth factor-like repeat A docking site using WaterMap Academic Article
Niche partitioning in the coevolution of 2 distinct RNA enzymes Academic Article
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Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity Academic Article
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Noncanonical NF-kappa B signaling is limited by classical NF-kappa B activity Academic Article
Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity Academic Article
Noncoded amino acid replacement probes of the aspartate aminotransferase mechanism Academic Article
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Not more than 117 base-pairs of 5'-flanking sequence are required for inducible expression of a human ifn-alpha gene Academic Article
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Octopamine receptor OAMB is required for ovulation in Drosophila melanogaster Academic Article
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Personalized circulating tumor DNA biomarkers dynamically predict treatment response and survival in gynecologic cancers Academic Article
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Phage-display evolution of tyrosine kinases with altered nucleotide specificity Academic Article
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Physiology and biochemistry of Drosophila learning mutants Academic Article
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Phytochrome B affects responsiveness to gibberellins in Arabidopsis Academic Article
Phytochrome signaling mechanisms and the control of plant development Academic Article
Phytochromes and cryptochromes in the entrainment of the Arabidopsis circadian clock Academic Article
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Prevalence of hemochromatosis-related symptoms among individuals with mutations in the hfe gene Academic Article
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Prion proteins with pathogenic and protective mutations show similar structure and dynamics Academic Article
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Proteomics opens doors to the mechanisms of developmentally regulated secretion Academic Article
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Purdue ionomics information management system. An integrated functional genomics platform Academic Article
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Quantitative proteomics and protein network analysis of hippocampal synapses of CaMKII alpha mutant mice Academic Article
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Release factor one is nonessential in Escherichia coli Academic Article
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Structural insight into pH-induced conformational changes within the native human transthyretin tetramer Academic Article
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor Academic Article
Structural insights into conformational flexibility at the peripheral site and within the active center gorge of ache Academic Article
Structural insights into neonatal Fc receptor-based recycling mechanisms Academic Article
Structural insights into the evolution of an antibody combining site Academic Article
Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins Academic Article
Structural mechanism associated with domain opening in gain-of-function mutations in SHP2 phosphatase Academic Article
Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach Academic Article
Structural plasticity and the evolution of antibody affinity and specificity Academic Article
Structurally novel antiestrogens elicit differential responses from constitutively active mutant estrogen receptors in breast cancer cells and tumors Academic Article
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Structure and dynamics of RNA repeat expansions that cause Huntington's disease and myotonic dystrophy type 1 Academic Article
Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly Academic Article
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Structure and function of an unusual family of protein phosphatases: the bacterial chemotaxis proteins CheC and CheX Academic Article
Structure and function of phage rna Academic Article
Structure and function of the von Willebrand factor A1 domain Academic Article
Structure and mechanism of the ruvb holliday junction branch migration motor Academic Article
Structure and molecular organization of mammalian fatty acid synthase Academic Article
Structure and receptor specificity of the hemagglutinin from an h5n1 influenza virus Academic Article
Structure determination of the antp(c39- s) homeodomain from nuclear-magnetic-resonance data in solution using a novel strategy for the structure calculation with the programs diana, caliba, habas and glomsa Academic Article
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Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Academic Article
Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase Academic Article
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator Academic Article
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Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone Academic Article
Structure of the I-1 early intermediate of photoactive yellow protein by FTIR spectroscopy Academic Article
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Structure of the heterodimeric complex between CAD domains of CAD and ICAD Academic Article
Structure of the human ATG12 similar to ATG5 conjugate required for LC3 lipidation in autophagy Academic Article
Structure of the inhibitory region of troponin by site directed spin labeling electron paramagnetic resonance Academic Article
Structure of the n terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members Academic Article
Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of Mycobacteria Academic Article
Structure, dynamics, and catalytic function of dihydrofolate reductase Academic Article
Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B Academic Article
Structure-activity relationships in a peptidic alpha 7 nicotinic acetylcholine receptor antagonist Academic Article
Structure-activity relationships in the binding of chemically derivatized cd4 to gp120 from human immunodeficiency virus Academic Article
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells Academic Article
Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death Academic Article
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457 Academic Article
Structures of thermolabile mutants of human glutathione transferase P1-1 Academic Article
Studies on control of development - isolation of bacillus-subtilis mutants blocked early in sporulation and defective in synthesis of highly phosphorylated nucleotides Academic Article
Substituting c-jun n-terminal kinase-3 (jnk3) atp-binding site amino acid residues with their p38 counterparts affects binding of jnk- and p38-selective inhibitors Academic Article
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Surface-plasmon resonance based kinetic-studies of zinc-finger DNA interactions Academic Article
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Synthetic peptide model of an essential region of an aminoacyl-tRNA synthetase Academic Article
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The selection of s-cerevisiae mutants defective in the start event of cell-division Academic Article
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l(3)malignant brain tumor and three novel genes are required for Drosophila germ-cell formation Academic Article
roX1 RNA paints the X chromosome of male Drosophila and is regulated by the dosage compensation system Academic Article
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β-hairpin-mediated nucleation of polyglutamine amyloid formation Academic Article

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