Mutation

subject area of

"Resistance" to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 do not confer resistance Academic Article
'Late onset' ornithine transcarbamylase deficiency: function of three purified recombinant mutant enzymes Academic Article
3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting Academic Article
5' cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved 5' GU Academic Article
A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2 Academic Article
A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon Academic Article
A CCHC metal-binding domain in Nanos is essential for translational regulation Academic Article
A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response Academic Article
A Saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability Academic Article
A THEMIS:SHP1 complex promotes T-cell survival Academic Article
A bacterial amber suppressor in Saccharomyces cerevisiae is selectively recognized by a bacterial aminoacyl-tRNA synthetase Academic Article
A base change in the catalytic core of the hairpin ribozyme perturbs function but not domain docking Academic Article
A base triple in the tetrahymena group i core affects the reaction equilibrium via a threshold effect Academic Article
A c-alpha model for the transmembrane alpha helices of gap junction intercellular channels Academic Article
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Academic Article
A cell cycle phosphoproteome of the yeast centrosome Academic Article
A cell-autonomous requirement for the cell cycle regulatory protein, rb, in neuronal migration Academic Article
A cell-cycle checkpoint monitors cell morphogenesis in budding yeast Academic Article
A chemical chaperone decouples TDP-43 disordered domain phase separation from fibrillation Academic Article
A chemical toolkit for proteins: an expanded genetic code Academic Article
A chiroselective peptide replicator Academic Article
A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease Academic Article
A clonal analysis of tergite development in Drosophila of ultraabdominal and paradoxical genotypes Academic Article
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells Academic Article
A conservative isoleucine to leucine mutation causes major rearrangements and cold sensitivity in KlenTaq1 DNA polymerase Academic Article
A conserved family of prolyl-4-hydroxylases that modify HIF Academic Article
A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins Academic Article
A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension Academic Article
A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function Academic Article
A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development Academic Article
A covering method for detecting genetic associations between rare variants and common phenotypes Academic Article
A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells Academic Article
A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics Academic Article
A crucial role for the putative Arabidopsis topoisomerase VI in plant growth and development Academic Article
A de novo designed peptide ligase: A mechanistic investigation Academic Article
A de novo protein binding pair by computational design and directed evolution Academic Article
A designed inhibitor of a CLC antiporter blocks function through a unique binding mode Academic Article
A di-acidic (DxE) code directs concentration of cargo during export from the endoplasmic reticulum Academic Article
A di-acidic signal required for selective export from the endoplasmic reticulum Academic Article
A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase Academic Article
A distinct set of drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory Academic Article
A dominant negative mutant of the E. Coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit Academic Article
A dominant-negative peroxisome proliferator-activated receptor gamma (ppar gamma) mutant is a constitutive repressor and inhibits ppar gamma-mediated adipogenesis Academic Article
A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory Academic Article
A dynamin mutant defines a superconstricted prefission state Academic Article
A family of cyclin homologs that control the g1 phase in yeast Academic Article
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity Academic Article
A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function Academic Article
A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity Academic Article
A general method for greatly improving the affinity of antibodies by using combinatorial libraries Academic Article
A general method for site-specific incorporation of unnatural amino acids into proteins Academic Article
A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers Academic Article
A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase Academic Article
A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe Academic Article
A glutamate switch controls voltage-sensitive phosphatase function Academic Article
A growth regulatory loop that provides homeostasis to phytochrome A signaling Academic Article
A guanosine to adenosine transition in the 3' terminal extracistronic region of bacteriophage Qβ RNA leading to loss of infectivity Academic Article
A helix replacement mechanism directs metavinculin functions Academic Article
A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B Academic Article
A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion Academic Article
A highly conserved neutralizing epitope on group 2 influenza a viruses Academic Article
A highly membrane-active peptide in Flock House virus: Implications for the mechanism of nodavirus infection Academic Article
A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1 Academic Article
A human germ line antibody light chain with hydrolytic properties associated with multimerization status Academic Article
A humanized anti-4-1bb monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates Academic Article
A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd Academic Article
A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses Academic Article
A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41 Academic Article
A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa Academic Article
A membrane-embedded amino acid couples the SpoIIQ channel protein to anti-sigma factor transcriptional repression during Bacillus subtilis sporulation Academic Article
A metal-binding motif implicated in RNA recognition by an aminoacyl-tRNA synthetase and by a retroviral gene product Academic Article
A method to site-specifically introduce methyllysine into proteins in E. coli Academic Article
A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron Academic Article
A missense mutation in the neutrophil cytochrome-b heavy-chain in cytochrome-positive x-linked chronic granulomatous-disease Academic Article
A molecular description of the evolution of resistance Academic Article
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration Academic Article
A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks Academic Article
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response Academic Article
A mutant of rous sarcoma virus (type o) causing fusiform cell transformation Academic Article
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function Academic Article
A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome Academic Article
A mutation in the FHA domain of Coprinus cinereus Nbs1 leads to Spo11-independent meiotic recombination and chromosome segregation Academic Article
A mutation in the human cyclin-dependent kinase interacting protein, ckshs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly Academic Article
A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters Academic Article
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα Academic Article
A new regulatory switch in a JAK protein kinase Academic Article
A new strategy for the synthesis of glycoproteins Academic Article
A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis Academic Article
A note on efficient estimation of mutation-rates using luria-delbruck fluctuation analysis Academic Article
A novel GJA8 mutation (p.V44A) causing autosomal dominant congenital cataract Academic Article
A novel cross-talk in diacylglycerol signaling the rac-gap beta 2-chimaerin is negatively regulated by protein kinase c delta-mediated phosphorylation Academic Article
A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex Academic Article
A novel promoter motif for caulobacter cell cycle-controlled DNA replication genes Academic Article
A novel splice acceptor site mutation which produces multiple splicing abnormalities resulting in protein S deficiency type I Academic Article
A novel technique for the rapid preparation of mutant RNAs Academic Article
A nucleoside transporter from Trypanosoma brucei involved in drug resistance Academic Article
A p47-phox pseudogene carries the most common mutation causing p47-phox-deficient chronic granulomatous disease Academic Article
A perspective on the structural and functional constraints for immune evasion: insights from influenza virus Academic Article
A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins Academic Article
A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor Academic Article
A plasma membrane H(+)-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana Academic Article
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Academic Article
A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins Academic Article
A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.Fem-3 mRNA complex Academic Article
A putative bacterial ABC transporter circumvents the essentiality of signal peptidase Academic Article
A quick diversity-oriented amide-forming reaction to optimize p-subsite residues of hiv protease inhibitors Academic Article
A rab1 mutant affecting guanine-nucleotide exchange promotes disassembly of the golgi-apparatus Academic Article
A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin Academic Article
A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90 Academic Article
A role for brassinosteroids in light-dependent development of Arabidopsis Academic Article
A role for dual viral hits in causation of subacute sclerosing panencephalitis Academic Article
A role for flavin monooxygenase-like enzymes in auxin biosynthesis Academic Article
A role for peroxisomes in photomorphogenesis and development of Arabidopsis Academic Article
A role for the P-body component GW182 in microRNA function Academic Article
A role for the swe1 checkpoint kinase during filamentous growth of saccharomyces cerevisiae Academic Article
A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib Academic Article
A role of the kinase mtor in cellular transformation induced by the oncoproteins p3k and akt Academic Article
A selective chemical probe for coenzyme a - requiring enzymes Academic Article
A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo Academic Article
A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth Academic Article
A siglec-like sialic-acid-binding motif revealed in an adenovirus capsid protein Academic Article
A silencer element in the retinoblastoma tumor-suppressor gene Academic Article
A simple structural feature is a major determinant of the identity of a transfer RNA Academic Article
A single amino-acid change in the mouse peroxisome proliferator-activated receptor-alpha alters transcriptional responses to peroxisome proliferators Academic Article
A single base pair affects binding and catalytic parameters in the molecular recognition of a transfer RNA Academic Article
A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression Academic Article
A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouse Academic Article
A sphingosine 1-phosphate receptor 2 selective allosteric agonist Academic Article
A structural view of evolutionary divergence Academic Article
A study of genes that may modulate the expression of hereditary hemochromatosis: Transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (irp)-1 and-2, and hepcidin Academic Article
A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase Academic Article
A temperature-sensitive lesion affecting levels of transformation-specific viral RNA in a mutant of avian sarcoma virus PRCII Academic Article
A transcriptional repressor obtained by alternative translation of a trinucleotide repeat Academic Article
A two-component signal transduction system essential for growth of bacillus subtilis: Implications for anti-infective therapy Academic Article
A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5 Academic Article
A unique gtp-dependent sporulation sensor histidine kinase in bacillus anthracis Academic Article
A virus-based nanoblock with tunable electrostatic properties Academic Article
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair Academic Article
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC Academic Article
AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin Academic Article
ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization Academic Article
ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import Academic Article
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1 Academic Article
Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine Academic Article
Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells Academic Article
Accessory mutations maintain stability in drug-resistant HIV-1 protease Academic Article
Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae Academic Article
Acidic food pH increases palatability and consumption and extends drosophila lifespan Academic Article
Acidification of endosome subpopulations in wild-type chinese-hamster ovary cells and temperature-sensitive acidification-defective mutants Academic Article
Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering Academic Article
Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions Academic Article
Activated protein C resistance caused by Arg506Gln mutation in factor Va Academic Article
Activated protein C variants with normal cytoprotective but reduced anticoagulant activity Academic Article
Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe Academic Article
Activation domain-dependent monoubiquitylation of Gal4 protein is essential for promoter binding in vivo Academic Article
Activation of snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos Academic Article
Activation of tumor cell integrin alpha(v)beta(3) controls angiogenesis and metastatic growth in the brain Academic Article
Activation tagging of the floral inducer FT Academic Article
Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast Academic Article
Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein Academic Article
Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties Academic Article
Active site residues of cyclophilin A are crucial for its signaling activity via CD147 Academic Article
Active site serine promotes stabilization of the reactive glutathione thiolate in rat glutathione transferase T2-2 - Evidence against proposed sulfatase activity of the corresponding human enzyme Academic Article
Active, interactive, and inactive steroid-receptor mutants Academic Article
Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3 Academic Article
Activity of yeast extracts in cell-free stimulation of DNA-replication Academic Article
Activity-guided engineering of natural product carrier proteins Academic Article
Adaptive mutations alter antibody structure and dynamics during affinity maturation Academic Article
Adenovirus core protein pvii is translocated into the nucleus by multiple import receptor pathways Academic Article
Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by rho family gtpases Academic Article
Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice Academic Article
Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie b-adenovirus receptor-bearing cells Academic Article
Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae Academic Article
Adult chicken alpha-globin gene-expression in transfected qt6 quail cells - evidence for a negative regulatory element in the alpha-d gene region Academic Article
Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling Academic Article
Age-related somatic structural changes in the nuclear genome of human blood cells Academic Article
Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes Academic Article
Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA Academic Article
All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase Academic Article
Alloreactive T cells discriminate among a diverse set of endogenous peptides Academic Article
Alteration of bacillus-subtilis glutamine-synthetase results in overproduction of enzyme Academic Article
Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant Academic Article
Alteration of the reduction potential of the 4fe-4s (2+/+) cluster of azotobacter vinelandii ferredoxin i Academic Article
Alteration of the α-synuclein folding landscape by a mutation related to Parkinson's disease Academic Article
Alterations in the flow of one-carbon units affect kinb-dependent sporulation in bacillus subtilis Academic Article
Altered chaperone-like activity of α-crystallins promotes cataractogenesis Academic Article
Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system Academic Article
Altered mRNA binding activity and decreased translation initiation in a nuclear mutant lacking translation of the chloroplast psbA mRNA Academic Article
Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery Academic Article
Alternative mutations of a positively selected residue elicit qain or loss of functionalities in enzyme evolution Academic Article
Alternative outcomes in assembly of promoter complexes: The roles of TBP and a flexible linker in placing TFIIIB on tRNA genes Academic Article
Alternative splicing within the ligand binding domain of the human constitutive androstane receptor Academic Article
Alzheimer's Aβ peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)? Academic Article
American College of Medical Genetics consensus statement on factor V Leiden mutation testing Academic Article
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase Academic Article
Amino acid substitution at the dimeric interface of human manganese superoxide dismutase Academic Article
Amino-acid replacements that compensate for a large polypeptide deletion in an enzyme Academic Article
Aminoacyl tRNA synthetases and their connections to disease Academic Article
Aminoacyl-tRNA synthetases: general features and recognition of transfer RNAs Academic Article
Amplification, mutation and selection of catalytic RNA Academic Article
Amplification, rearrangement, and elevated expression of c-myc in the human prostatic carcinoma cell line LNCaP Academic Article
Amyloid diseases: Abnormal protein aggregation in neurodegeneration Academic Article
Amyotrophic Lateral Sclerosis Academic Article
Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase Academic Article
An Arabidopsis mutant defective in the plastid general protein import apparatus Academic Article
An Arabidopsis thaliana virescent mutant reveals a role for ClpR1 in plastid development Academic Article
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence Academic Article
An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors Academic Article
An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide Academic Article
An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway Academic Article
An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model Academic Article
An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening Academic Article
An association of candidate gene haplotypes and bleeding severity in von willebrand disease type 2a, 2b, and 2m pedigrees Academic Article
An engineered virus as a scaffold for three-dimensional self-assembly on the nanoscale Academic Article
An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes Academic Article
An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses Academic Article
An essential GTpase promotes assembly of preribosomal RNA processing complexes Academic Article
An essential g1 function for cyclin-like proteins in yeast Academic Article
An expanded eukaryotic genetic code Academic Article
An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system Academic Article
An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae Academic Article
An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5 Academic Article
An intact conformation at the tip of elongation factor G domain IV is functionally important Academic Article
An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity Academic Article
An interchromosomal gene conversion of the Drosophila dunce locus identified with restriction site polymorphisms: a potential involvement of transposable elements in gene conversion Academic Article
An intracellular signal transduction pathway between the chloroplast and nucleus is involved in de-etiolation Academic Article
An isogenic human ESC platform for functional evaluation of genome-wide-association-study-identified diabetes genes and drug discovery Academic Article
An mrna-rrna base-pairing mechanism for translation initiation in eukaryotes Academic Article
An online resource for GPCR structure determination and analysis Academic Article
An orthogonal DNA replication system in yeast Academic Article
An unexpected outcome of surface engineering an integral membrane protein: Improved crystallization of cytochrome ba(3) from thermus thermophilus Academic Article
Analysis by electron-microscopy of early simian-virus 40 rna from a tsa mutant Academic Article
Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries Academic Article
Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor Academic Article
Analysis of individual immunoglobulin-lambda light-chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center b-cell somatic mutation Academic Article
Analysis of male pheromones that accelerate female reproductive organ development Academic Article
Analysis of novel residues of class I involved in recognition by alloreactive T cells Academic Article
Analysis of rrna processing and translation in mammalian cells using a synthetic 18s rrna expression system Academic Article
Analysis of stop-gain and frameshift variants in human innate immunity genes Academic Article
Analyzing and tuning ribozyme activity by deep sequencing to modulate gene expression level in mammalian cells Academic Article
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase Academic Article
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity Academic Article
Antibodies against small nuclear ribonucleoproteins immunoprecipitate complexes containing ts110 Moloney murine sarcoma virus genomic and messenger RNAs Academic Article
Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics Academic Article
Antigen presentation and t cell development in h2-m-deficient mice Academic Article
Antigen-driven B cell differentiation in vivo Academic Article
Antigenic analyses of influenza-virus hemagglutinins with different receptor-binding specificities Academic Article
Antisense masking reveals contributions of mrna- rrna base pairing to translation of gtx and fgf2 mrnas Academic Article
Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors Academic Article
Application of site-directed mutagenesis to rna and DNA genomes Academic Article
Approaches for skeletal gene therapy Academic Article
Arabidopsis MYB30 is a direct target of BES1 and cooperates with BES1 to regulate brassinosteroid-induced gene expression Academic Article
Arabidopsis thaliana mutant that develops as a light-grown plant in the absence of light Academic Article
Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation Academic Article
Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors Academic Article
Architecture of the flagellar rotor Academic Article
Arenavirus diversity and evolution: Quasispecies in vivo Academic Article
Arenavirus extinction through lethal mutagenesis Academic Article
Aromatic residues in the C-terminal region of glutathione transferase A1-1 influence rate-determining steps in the catalytic mechanism Academic Article
Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein Academic Article
Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase Academic Article
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility Academic Article
Assembly of the covalent linkage between lipoic acid and its cognate enzymes Academic Article
Assignment of the L30-mRNA complex using selective isotopic labeling and RNA mutants Academic Article
Association between a disrupted-in-schizophrenia 1 (disc1) single nucleotide polymorphism and schizophrenia in a combined scandinavian case-control sample Academic Article
Association between thromboembolic events and the JAK2 V617F mutation in myeloproliferative neoplasms Academic Article
Association of the 2-mu-m DNA plasmid with yeast folded chromosomes Academic Article
Associations between phylogenetic clustering and HLA profile among HIV-infected individuals in San Diego, California Academic Article
Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificities Academic Article
Atl1 regulates choice between global genome and transcription-coupled repair of o-6-alkylguanines Academic Article
Atomic accuracy in predicting and designing noncanonical RNA structure Academic Article
Atomic structures of wild-type and thermostable mutant recombinant human cu,zn superoxide-dismutase Academic Article
Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex Academic Article
Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface Academic Article
Autoantibodies as reporters identifying aberrant cellular mechanisms in tumorigenesis Academic Article
Automated analysis of hypocotyl growth dynamics during shade avoidance in Arabidopsis Academic Article
Automated identification of functional dynamic contact networks from X-ray crystallography Academic Article
Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity Academic Article
Autoproteolysis in nucleoporin biogenesis Academic Article
Autoregulation of simian virus-40 gene-a by t-antigen Academic Article
Avian-sarcoma virus mutant that is temperature sensitive for virion assembly Academic Article
Avian-sarcoma virus prcii - conditional mutants temperature sensitive in the maintenance of fibroblast transformation Academic Article
Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential Academic Article
BACE1- and BACE2-expressing human cells - characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors Academic Article
BAS1: A gene regulating brassinosteroid levels and light responsiveness in Arabidopsis Academic Article
BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice Academic Article
BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation Academic Article
BIG: a calossin-like protein required for polar auxin transport in Arabidopsis Academic Article
BIN2, a new brassinosteroid-insensitive locus in Arabidopsis Academic Article
BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis Academic Article
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis Academic Article
BRANCHED1 interacts with FLOWERING LOCUS T to repress the floral transition of the axillary meristems in Arabidopsis Academic Article
BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint Academic Article
BRI1 is a critical component of a plasma-membrane receptor for plant steroids Academic Article
BRL1 and BRL3 are novel brassinosteroid receptors that function in vascular differentiation in Arabidopsis Academic Article
Bacillus subtilis chec and fliy are members of a novel class of chey-p-hydrolyzing proteins in the chemotactic signal transduction cascade Academic Article
Backbone-backbone H-bonds make context-dependent contributions to protein folding kinetics and thermodynamics: lessons from amide-to-ester mutations Academic Article
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin Academic Article
Balanced electrostatic and structural forces guide the large conformational change associated with maturation of t=4 virus Academic Article
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA Academic Article
Base pairing between hepatitis C virus RNA and 18S rRNA is required for IRES-dependent translation initiation in vivo Academic Article
Bcl-2 is an apoptotic target suppressed by both c-myc and e2f-1 Academic Article
Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis Academic Article
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3 Academic Article
Beware of multiple comparisons: A study of symptoms associated with mutations of the hfe hemochromatosis gene Academic Article
Biallelic mutations in IRF8 impair human NK cell maturation and function Academic Article
Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease Academic Article
Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome p450 46a1 unusual features and spectral response Academic Article
Binding of neural cell adhesion molecules (n-cams) to the cellular prion protein Academic Article
Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity Academic Article
Biobanking: an important resource for precision medicine in glioblastoma Academic Article
Biochemical characterization and crystal structure of a dim1 family associated protein: Dim2 Academic Article
Biochemical characterization of Arabidopsis wild-type and mutant phytochrome B holoproteins Academic Article
Biochemical characterization of the Caenorhabditis elegans FBF. CPB-1 translational regulation complex identifies conserved protein interaction hotspots Academic Article
Biochemical characterization of the tata-binding protein-gal4 activation domain complex Academic Article
Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1 Academic Article
Biochemical-characterization of the essential gtp-binding protein obg of bacillus-subtilis Academic Article
Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis Academic Article
Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants Academic Article
Biomarkers of endocannabinoid system activation in severe obesity Academic Article
Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes Academic Article
Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors Academic Article
Biosynthesis of the enediyne antitumor antibiotic c-1027 Academic Article
Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants Academic Article
Blockade of CD14 aggravates experimental shigellosis Academic Article
BluB cannibalizes flavin to form the lower ligand of vitamin B-12 Academic Article
Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of hfe, transferrin receptor 2 (tfr2), and il-6 Academic Article
Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA Academic Article
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor Academic Article
Brassinosteroid regulates cell elongation by modulating gibberellin metabolism in rice Academic Article
Brassinosteroid signaling and auxin transport are required to establish the periodic pattern of Arabidopsis shoot vascular bundles Academic Article
Brassinosteroid signaling: a paradigm for steroid hormone signaling from the cell surface Academic Article
Brassinosteroids control male fertility by regulating the expression of key genes involved in Arabidopsis anther and pollen development Academic Article
Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin Academic Article
Bromocriptine produces decreases in cocaine self-administration in the rat Academic Article
Bud6 directs sequential microtubule interactions with the bud tip and bud neck during spindle morphogenesis in saccharomyces cerevisiae Academic Article
Budding yeast centrosome duplication requires stabilization of Spc29 via Mps1-mediated phosphorylation Academic Article
Buffer enhancement of proton-transfer in catalysis by human carbonic anhydrase-iii Academic Article
Bulk segregant analysis using single nucleotide polymorphism microarrays Academic Article
Bulk segregation mapping of mutations in closely related strains of mice Academic Article
C-13 NMR evidence that substitution of glutamine for arginine-3500 in familial defective apolipoprotein-b-100 disrupts the conformation of the receptor-binding domain Academic Article
C-fos is required for malignant progression of skin tumors Academic Article
C-myc augments gamma irradiation-induced apoptosis by suppressing bcl-x-l Academic Article
C-myc-mediated regulation of telomerase activity is disabled in immortalized cells Academic Article
C-o bond formation by polyketide synthases Academic Article
C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1 Academic Article
CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity Academic Article
CD4-independent binding of SIV gp120 to rhesus CCR5 Academic Article
CD44 receptor unfolding enhances binding by freeing basic amino acids to contact carbohydrate ligand Academic Article
CFTR Folding Consortium: methods available for studies of CFTR folding and correction Academic Article
CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses Academic Article
CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase Academic Article
CO2 fixation kinetics of Halothiobacillus neapolitanus mutant carboxysomes lacking carbonic anhydrase suggest the shell acts as a diffusional barrier for CO2 Academic Article
COPII vesicles derived from mammalian endoplasmic reticulum microsomes recruit COPI Academic Article
COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a di-acidic exit code Academic Article
CTL escape viral variants. II. Biologic activity in vivo Academic Article
Ca2+ binding protects against gelsolin amyloidosis Academic Article
Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans Academic Article
Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells Academic Article
Cadherins and mechanotransduction by hair cells Academic Article
Caenorhabditis elegans TRPA-1 functions in mechanosensation Academic Article
Cancer driver mutations in protein kinase genes Academic Article
Cancer-derived mutations in the regulatory subunit p85α of phosphoinositide 3-kinase function through the catalytic subunit p110α Academic Article
Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity Academic Article
Cancer-specific mutations in PIK3CA are oncogenic in vivo Academic Article
Cancer-specific mutations in phosphatidylinositol 3-kinase Academic Article
Cancer: Aneuploidy drives a mutator phenotype in cancer Academic Article
Catalytic activity is retained in the Tetrahymena group-I intron despite removal of the large extension of element P5 Academic Article
Catecholamines in mutant mouse cerebellum - fluorescence microscopic and chemical studies Academic Article
Cathepsin g, a leukocyte protease, activates coagulation factorviii Academic Article
Cd14 is required for myd88-independent lps signaling Academic Article
Cd36 is a sensor of diacylglycerides Academic Article
Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase Academic Article
Cdc53 targets phosphorylated g1 cyclins for degradation by the ubiquitin proteolytic pathway Academic Article
Cdk1 coordinates cell-surface growth with the cell cycle Academic Article
Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1 Academic Article
Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers Academic Article
Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase Academic Article
Cell death in Escherichia coli dnaE(Ts) mutants incubated at a nonpermissive temperature is prevented by mutation in the cydA gene Academic Article
Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast Academic Article
Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions Academic Article
Cellular function of protein phosphatase 2C in yeast Academic Article
Ceramide mediates the rapid phase of febrile response to IL-1β Academic Article
Changes in crystallographic structure and thermostability of a Cu,Zn superoxide-dismutase mutant resulting from the removal of a buried cysteine Academic Article
Changes in the V3 region of gp 120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta 32 heterozygote Academic Article
Characteristics of a Bacillus subtilis W23 mutant temperature sensitive for initiation of chromosome replication Academic Article
Characterization by (1)H NMR of a C32S,C35S double mutant of Escherichia coli thioredoxin confirms its resemblance to the reduced wild-type protein Academic Article
Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis Academic Article
Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo Academic Article
Characterization of a putative founder mutation that accounts for the high incidence of cystinosis in brittany Academic Article
Characterization of a selective inhibitor of the parkinson's disease kinase lrrk2 Academic Article
Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va Academic Article
Characterization of autoregulation of simian virus-40 gene-a Academic Article
Characterization of fdmv as an amide synthetase for fredericamycin a biosynthesis in streptomyces griseus atcc 43944 Academic Article
Characterization of global yeast quantitative proteome data generated from the wild-type and glucose repression Saccharomyces cerevisiae strains: the comparison of two quantitative methods Academic Article
Characterization of mouse mutants with abnormal RPE cells Academic Article
Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB Academic Article
Characterization of the escherichia-coli transcription factor-delta-70 - localization of a region involved in the interaction with core rna-polymerase Academic Article
Characterization of the human protein S gene promoter: a possible role of transcription factors Sp1 and HNF3 in liver Academic Article
Characterization of the iron-sulfur cluster n7 (n1c) in the subunit nuog of the proton-translocating nadh-quinone oxidoreductase from escherichia coli Academic Article
Characterization of the requirements for localization of phytochrome B to nuclear bodies Academic Article
Characterization of the spo0a locus and its deduced product Academic Article
Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect Academic Article
Chemical selection of mutants that affect alcohol dehydrogenase in Drosophila. II. Use of 1-pentyne-3-ol Academic Article
Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1 Academic Article
Chemotype-selective modes of action of κ-opioid receptor agonists Academic Article
Chimeric molecules created by gene amplification interfere with the analysis of somatic hypermutation of murine immunoglobulin genes Academic Article
Chromosomal integration dependent induction of junb by growth factors requires multiple flanking evolutionarily conserved sequences Academic Article
Chromosomal location and properties of radiation sensitivity mutations in bacillus subtilis Academic Article
Chromosomal location of pleiotropic negative sporulation mutations in bacillus-subtilis Academic Article
Chronic inflammation does not appear to modify the homozygous hereditary hemochromatosis phenotype Academic Article
Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA Academic Article
Cip1 and Cip2 are novel RNA-recognition-motif proteins that counteract Csx1 function during oxidative stress Academic Article
Cipc is a mammalian circadian clock protein without invertebrate homologues Academic Article
Circadian clock mutants in Arabidopsis identified by luciferase imaging Academic Article
Circadian rhythms from flies to human Academic Article
Circadian rhythms. As time PASses: the first mammalian clock gene Academic Article
Circulating activated protein C in subjects with heterozygous GIn506-factor V Academic Article
Cis-acting sequences may contribute to size variation in the surface glycoprotein of bovine immunodeficiency virus Academic Article
Cis-preferential recruitment of duck hepatitis B virus core protein to the RNA/polymerase preassembly complex Academic Article
Citric acid cycle: Gene-enzyme relationships in bacillus subtilis Academic Article
Class ipi3k in oncogenic cellular transformation Academic Article
Class-ii defective avian-sarcoma viruses - comparative-analysis of genome structure Academic Article
Clb5-associated kinase activity is required early in the spindle pathway for correct preanaphase nuclear positioning in saccharomyces cerevisiae Academic Article
Climbing Darwins ladder Academic Article
Clinical analysis of NSCLC patients reveals lack of association between EGFR mutation and TET1 downregulation Academic Article
Clinical sequencing uncovers origins and evolution of Lassa virus Academic Article
Cln3, not positive feedback, determines the timing of cln2 transcription in cycling cells Academic Article
Cloned DNA of defective avian-sarcoma virus mutant la46 encodes the cis-acting temperature-sensitive defect in replication Academic Article
Cloning and in vivo and in vitro regulation of cyclic AMP-dependent carbon starvation genes from Escherichia coli Academic Article
Cloning of GLN4: an essential gene that encodes glutaminyl-tRNA synthetase in Saccharomyces cerevisiae Academic Article
Cloning of a human cdna-encoding a cdc2-related kinase by complementation of a budding yeast cdc28 mutation Academic Article
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus Academic Article
CoVaMa: Co-Variation Mapper for disequilibrium analysis of mutant loci in viral populations using next-generation sequence data Academic Article
Coevolution of cells and viruses in a persistent infection of foot-and-mouth-disease virus in cell-culture Academic Article
Cognitive aging in zebrafish Academic Article
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing Academic Article
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer Academic Article
Combinatorial antibody libraries from survivors of the turkish h5n1 avian influenza outbreak reveal virus neutralization strategies Academic Article
Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation Academic Article
Common charge-shift mutation glu65lys in k(+) channel beta(1)-subunit kcnmb1: Pleiotropic consequences for glomerular filtration rate and progressive renal disease Academic Article
Common membrane trafficking defects of disease-associated dynamin 2 mutations Academic Article
Common tmprss6 mutations and iron, erythrocyte, and pica phenotypes in 48 women with iron deficiency or depletion Academic Article
Common vs. Rare allele hypotheses for complex diseases Academic Article
Comparative expression of TNF-alpha alleles from normal and autoimmune-prone MHC haplotypes Academic Article
Comparative modeling of the three CP modules of the beta-chain of C4BP and evaluation of potential sites of interaction with protein S Academic Article
Comparison of mice with accelerated aging caused by distinct mechanisms Academic Article
Comparison of the convergent receptor utilization of a retargeted feline leukemia virus envelope with a naturally-occurring porcine endogenous retrovirus a Academic Article
Complementary use of chemical modification and site-directed mutagenesis to probe structure activity relationships in enzymes Academic Article
Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin Academic Article
Complete replication of hepatitis C virus in cell culture Academic Article
Complete sequence and transcriptional analysis of the spo0f region of the bacillus-subtilis chromosome Academic Article
Computational design of proteins targeting the conserved stem region of influenza hemagglutinin Academic Article
Computational modeling of structurally conserved cancer mutations in the ret and met kinases: The impact on protein structure, dynamics, and stability Academic Article
Concerted kinetic folding of a multidomain ribozyme with a disrupted loop-receptor interaction Academic Article
Conditional circadian dysfunction of the Arabidopsis early-flowering 3 mutant Academic Article
Conditional dihydrostreptomycin resistance in bacillus subtilis Academic Article
Conditional lethal mutants of avian sarcoma viruses. Ii. Analysis of the temperature-sensitive lesion in ts 75 Academic Article
Conformational and dynamic characterization of the molten globule state of an apomyoglobin mutant with an altered folding pathway Academic Article
Conformational dynamics and stability of HP35 studied with 2D IR vibrational echoes Academic Article
Conformational heterogeneity and the affinity of substrate molecular recognition by cytochrome P450cam Academic Article
Conformational switching between protein substates studied with 2D IR vibrational echo spectroscopy and molecular dynamics simulations Academic Article
Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms Academic Article
Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast Academic Article
Consequences of the loss of o-linked glycosylation of meningococcal type iv pilin on piliation and pilus-mediated adhesion Academic Article
Conservation of function between mammalian and plant steroid 5α-reductases Academic Article
Conserved amino acid residues in the complementarity-determining region 1 of the TCR β-chain are involved in the recognition of conventional Ag and Mls-1 superantigen Academic Article
Conserved amino acid residues of the NuoD segment important for structure and function of Escherichia coli NDH-1 (complex I) Academic Article
Conserved glycine 232 in the ligand channel of ba(3) cytochrome oxidase from Thermus thermophilus Academic Article
Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate Academic Article
Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback Academic Article
Construction and analysis of deletions in the amino-terminal extension of glutamine tRNA synthetase of Saccharomyces cerevisiae Academic Article
Construction and properties of an integrable plasmid for bacillus-subtilis Academic Article
Context-dependent contributions of backbone hydrogen bonding to β-sheet folding energetics Academic Article
Continuous in vitro evolution of catalytic function Academic Article
Contribution of LCMV towards deciphering biology of quasispecies in vivo Academic Article
Contribution of charged amino acids in the CDR2 region of CD4 to HIV-1 gp120 binding Academic Article
Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase P1-1 Academic Article
Contribution of mutations in known Mendelian glaucoma genes to advanced early-onset primary open-angle glaucoma Academic Article
Control of circadian rhythms and photoperiodic flowering by the Arabidopsis GIGANTEA gene Academic Article
Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition Academic Article
Control of protein phosphorylation with a genetically encoded photocaged amino acid Academic Article
Control of translocations between highly diverged genes by Sgs1, the Saccharomyces cerevisiae homolog of the Bloom's syndrome protein Academic Article
Controlling mutation: Intervening in evolution as a therapeutic strategy Academic Article
Conversion of Glu-plasminogen to Lys-plasminogen is necessary for optimal stimulation of plasminogen activation on the endothelial cell surface Academic Article
Cooperation between both Wnt/β-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion Academic Article
Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast Academic Article
Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response Academic Article
Coordinated transcription of key pathways in the mouse by the circadian clock Academic Article
Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1 Academic Article
Copia RNA levels are elevated in dunce mutants and modulated by cAMP Academic Article
Copper-based pulsed dipolar ESR spectroscopy as a probe of protein conformation linked to disease states Academic Article
Coprinus cinereus rad50 mutants reveal an essential structural role for rad50 in axial element and synaptonemal complex formation, homolog pairing and meiotic recombination Academic Article
Copy number variations of TBK1 in Australian patients with primary open-angle glaucoma Academic Article
Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease Academic Article
Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB Academic Article
Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development Academic Article
Coumarin derivatives as substrate probes of mammalian cytochromes P450 2B4 and 2B6: assessing the importance of 7-Alkoxy chain length, halogen substitution, and non-active site mutations Academic Article
Coupling of receptor conformation and ligand orientation determine graded activity Academic Article
Critical function of γH2A in S-phase Academic Article
Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast Academic Article
Critical role for CCA1 and LHY in maintaining circadian rhythmicity in Arabidopsis Academic Article
Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling Academic Article
Critical roles of subunit nuoh (nd1) in the assembly of peripheral subunits with the membrane domain of escherichia coli ndh-1 Academic Article
Cross-neutralization of influenza a viruses mediated by a single antibody loop Academic Article
Cross-talk between snurportin1 subdomains Academic Article
Crosslinking of and coupling to viral capsid proteins by tyrosine oxidation Academic Article
Cryo-electron microscopy structure of adenovirus type 2 temperature-sensitive mutant 1 reveals insight into the cell entry defect Academic Article
Cryptochrome 1 and phytochrome B control shade-avoidance responses in Arabidopsis via partially independent hormonal cascades Academic Article
Cryptochromes are required for phytochrome signaling to the circadian clock but not for rhythmicity Academic Article
Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1 Academic Article
Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue Academic Article
Crystal structure of a phosphatase-resistant mutant of sporulation response regulator spo0f from bacillus subtilis Academic Article
Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3 Academic Article
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran Academic Article
Crystal structure of the anti-viral apobec3g catalytic domain and functional implications Academic Article
Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a k(+) channel inhibitor-like fold Academic Article
Crystal structure of the gtpase domain of rat dynamin 1 Academic Article
Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases Academic Article
Crystal structures of ferredoxin variants exhibiting large changes in fe-s reduction potential Academic Article
Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases Academic Article
Crystal structures of human topoisomerase i in covalent and noncovalent complexes with DNA Academic Article
Crystal-structure of the glu-239- gln mutant of aspartate carbamoyltransferase at 3.1-a resolution - an intermediate quaternary structure Academic Article
Crystallin gamma B-I4F mutant protein binds to alpha-crystallin and affects lens transparency Academic Article
Crystallographic characterization of recombinant human CuZn superoxide-dismutase Academic Article
Crystallography of the integral membrane protein emre from escherichia coli Academic Article
CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks Academic Article
Cutting edge: The tyrosine phosphatase SHP-1 regulates thymocyte positive selection Academic Article
Cyclin e-induced s phase without activation of the prb/e2f pathway Academic Article
Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts Academic Article
Cyclin-dependent kinase and cks/suc1 interact with the proteasome in yeast to control proteolysis of m-phase targets Academic Article
Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation Academic Article
Cystic fibrosis in an era of genomically guided therapy Academic Article
D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis Academic Article
DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid Academic Article
DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain Academic Article
DET1, a negative regulator of light-mediated development and gene expression in arabidopsis, encodes a novel nuclear-localized protein Academic Article
DNA binding domain in the replication checkpoint protein Mrc1 of Schizosaccharomyces pombe Academic Article
DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes Academic Article
DNA repair pathway selection caused by defects in TEL1, SAE2, and de novo telomere addition generates specific chromosomal rearrangement signatures Academic Article
DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos Academic Article
DNA-binding site for two skeletal actin promoter factors is important for expression in muscle cells Academic Article
DNA-bound structures and mutants reveal abasic DNA binding by ape1 DNA repair and coordination Academic Article
DNA-sequences preceding the rabbit beta-globin gene are required for formation in mouse l cells of beta-globin rna with the correct 5' terminus Academic Article
DWARF AND LOW-TILLERING acts as a direct downstream target of a GSK3/SHAGGY-like kinase to mediate brassinosteroid responses in rice Academic Article
Darwinian evolution of prions in cell culture Academic Article
Dax1 mutations map to putative structural domains in a deduced three-dimensional model Academic Article
Deactivation of the sporulation transcription factor spo0a by the spo0e protein phosphatase Academic Article
Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function Academic Article
Decoration of discretely immobilized cowpea mosaic virus with luminescent quantum dots Academic Article
Deep mutational scanning: a new style of protein science Academic Article
Deep mutational scanning: assessing protein function on a massive scale Academic Article
Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs Academic Article
Deep sequencing of protease inhibitor resistant HIV patient isolates reveals patterns of correlated mutations in Gag and protease Academic Article
Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex Academic Article
Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster Academic Article
Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function Academic Article
Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation Academic Article
Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy Academic Article
Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro Academic Article
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels Academic Article
Deletion of amino acids glu146 -> arg160 in human apolipoprotein a-i (apoa-i-seattle) alters lecithin : Cholesterol acyltransferase activity and recruitment of cell phospholipid Academic Article
Deletion of the nucleotide excision repair gene ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions Academic Article
Deoxyribonucleic acid-binding proteins in vegetative bacillus-subtilis - alterations caused by stage o sporulation mutations Academic Article
Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site Academic Article
Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress Academic Article
Deregulated cyclin e induces chromosome instability Academic Article
Design and characterization of a DNA-encoded, voltage-sensitive fluorescent protein Academic Article
Design and characterization of stabilized derivatives of human cd4d12 and cd4d1 Academic Article
Design and discovery of new combinations of mutant DNA polymerases and modified DNA substrates Academic Article
Design of RNAi hairpins for mutation-specific silencing of ataxin-7 and correction of a SCA7 phenotype Academic Article
Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses Academic Article
Designing sequence to control protein function in an EF-hand protein Academic Article
Destabilization of Ca2+-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type Academic Article
Destabilizing mutations encode nongenetic variation that drives evolutionary innovation Academic Article
Detailed mechanisms of the inactivation of factor viiia by activated protein c in the presence of its cofactors, protein s and factor v Academic Article
Detecting genetic variation in microarray expression data Academic Article
Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing Academic Article
Determination of defective function in 2 mutants of rous-sarcoma virus Academic Article
Determination of the chromosomal locations of 4 bacillus-subtilis genes which code for a family of small, acid-soluble spore proteins Academic Article
Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins Academic Article
Development and maintenance of a b220(-) memory b cell compartment Academic Article
Development of improved tRNAs for in vitro biosynthesis of proteins containing unnatural amino acids Academic Article
Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor Academic Article
Development of oseltamivir phosphonate congeners as anti-influenza agents Academic Article
Development of the next generation of HIV-1 integrase inhibitors: pyrazolone as a novel inhibitor scaffold Academic Article
Developmental function of the PHR protein RPM-1 is required for learning in Caenorhabditis elegans Academic Article
Dexamethasone stimulates endothelin-1 gene expression in renal collecting duct cells Academic Article
Dhhc5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells Academic Article
Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans Academic Article
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons Academic Article
Different states of synaptotagmin regulate evoked versus spontaneous release Academic Article
Differential contribution of bud6p and kar9p to microtubule capture and spindle orientation in s-cerevisiae Academic Article
Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone Academic Article
Differential regulation of transcription of p21 and cyclin D1 conferred by TAF(II)250 Academic Article
Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis Academic Article
Difuran-substituted quinoxalines as a novel class of PI3Kα H1047R mutant inhibitors: Synthesis, biological evaluation and structure-activity relationship Academic Article
Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly Academic Article
Direct observation of structural heterogeneity in a β-sheet Academic Article
Direct single-molecule observation of a protein living in two opposed native structures Academic Article
Directed enzyme evolution guided by multidimensional analysis of substrate-activity space Academic Article
Directed evolution of DNA polymerases for next-generation sequencing Academic Article
Directed evolution of N-acetylneuraminic acid aldolase to catalyze enantiomeric aldol reactions Academic Article
Directed evolution of an enhanced and highly efficient foki cleavage domain for zinc finger nucleases Academic Article
Directed evolution of d-sialic acid aldolase to l-3-deoxy-manno-2-octulosonic acid (l-kdo) aldolase Academic Article
Directed evolution of recombinase specificity by split gene reassembly Academic Article
Directed mutagenesis of the redox-active disulfide in the flavoenzyme mercuric ion reductase Academic Article
Directed polymerase evolution Academic Article
Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-m ethyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through structure-based drug design: a high affinity irreversible inhibitor targeting oncogenic EGFR mutants with selectivity over wild-type EGFR Academic Article
Discovery of a drug candidate for GLIS3-associated diabetes Academic Article
Discovery of a noncovalent, mutant-selective epidermal growth factor receptor inhibitor Academic Article
Discovery of a novel class of negative allosteric modulator of the dopamine D-2 receptor through fragmentation of a bitopic ligand Academic Article
Discovery of an auto-regulation mechanism for the maltose ABC transporter MalFGK2 Academic Article
Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation Academic Article
Disease severity and thin filament regulation in M9R TPM3 nemaline myopathy Academic Article
Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening Academic Article
Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F Academic Article
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells Academic Article
Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease Academic Article
Disruption of dendritic translation of camkii alpha impairs stabilization of synaptic plasticity and memory consolidation Academic Article
Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis Academic Article
Disruption of the arf-mdm2-p53 tumor suppressor pathway in myc-induced lymphomagenesis Academic Article
Dissecting mammalian immunity through mutation Academic Article
Dissecting the functional domains of a nonenveloped virus membrane penetration peptide Academic Article
Dissecting the structure, thermodynamic stability, and aggregation properties of the A25T transthyretin (A25T-TTR) variant involved in leptomeningeal amyloidosis: identifying protein partners that co-aggregate during A25T-TTR fibrillogenesis in cerebrospinal fluid Academic Article
Dissection of gain control mechanisms in Drosophila mechanotransduction Academic Article
Dissection of the B10.D2 anti-H-2Kb cytolytic T lymphocyte receptor repertoire Academic Article
Dissection of the functional and structural domains of phosphorelay histidine kinase a of bacillus subtilis Academic Article
Distinct conformations of the kinesin unc104 neck regulate a monomer to dimer motor transition Academic Article
Distinct endocytic mechanisms of cd22 (siglec-2) and siglec-f reflect roles in cell signaling and innate immunity Academic Article
Distinct mechanisms control the stability of the related s-phase cyclins clb5 and clb6 Academic Article
Distinct modes of cyclin e/cdc2c kinase regulation and s-phase control in mitotic endoreduplication cycles of drosophila embryogenesis Academic Article
Distinct patterns of somatic alterations in a lymphoblastoid and a tumor genome derived from the same individual Academic Article
Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe Academic Article
Disulfide bond isomerization in bpti and bpti(g36s) - an NMR-study of correlated mobility in proteins Academic Article
Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin Academic Article
Disulfide-bond formation by a single cysteine mutation in adenovirus protein vi impairs capsid release and membrane lysis Academic Article
Divergent evolution of protein conformational dynamics in dihydrofolate reductase Academic Article
Diverging catalytic capacities and selectivity profiles with haloalkane substrates of chimeric alpha class glutathione transferases Academic Article
Divide and conquer: Nucleotide excision repair battles cancer and ageing Academic Article
Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein dma1 in fission yeast Academic Article
Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor Academic Article
Domains of the qin protein required for oncogenic transformation Academic Article
Dominant Mutations in S. cerevisiae PMS1 Identify the Mlh1-Pms1 Endonuclease Active Site and an Exonuclease 1-Independent Mismatch Repair Pathway Academic Article
Dominant cataracts result from incongruous mixing of wild-type lens connexins Academic Article
Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy Academic Article
Dominant negative inhibition by fragments of a monomeric enzyme Academic Article
Dominant negative protein-kinase mutations that confer a g1 arrest phenotype Academic Article
Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis Academic Article
Dominant-interfering hsc70 mutants disrupt multiple stages of the clathrin-coated vesicle cycle in vivo Academic Article
Dosage suppressors of pds1 implicate ubiquitin-associated domains in checkpoint control Academic Article
Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake Academic Article
Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients Academic Article
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc) Academic Article
Drosophila cyclic nucleotide phosphodiesterases Academic Article
Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol Academic Article
Dual role of TOC1 in the control of circadian and photomorphogenic responses in Arabidopsis Academic Article
Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins Academic Article
Dual selection of a genetic switch by a single selection marker Academic Article
Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system Academic Article
Dynamic simulations of the molecular conformations of wild type and mutant xanthan polymers suggest that conformational differences may contribute to observed differences in viscosity Academic Article
Dynamin gtpase domain mutants that differentially affect gtp binding, gtp hydrolysis, and clathrin-mediated endocytosis Academic Article
Dynamin-catalyzed membrane fission requires coordinated GTP hydrolysis Academic Article
ELF3 modulates resetting of the circadian clock in Arabidopsis Academic Article
ENU-induced phenovariance in mice: Inferences from 587 mutations Academic Article
EPHA2 is associated with age-related cortical cataract in mice and humans Academic Article
ERdj3 Is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher's disease Academic Article
Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase Academic Article
Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone Academic Article
Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion Academic Article
Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration Academic Article
Effect of correcting transferrin saturation for body mass index in HFE C282Y homozygotes Academic Article
Effect of gamma-interferon on cachectin expression by mononuclear phagocytes - reversal of the lpsd (endotoxin resistance) phenotype Academic Article
Effect of mutations at the lariat branch acceptor site on beta-globin pre-mRNA splicing in vitro Academic Article
Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza h5n1 viruses Academic Article
Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life Academic Article
Effect of stage-0 sporulation mutations on subtilisin expression Academic Article
Effect of the ubiquitous transcription factors, SP1 and MAZ, on NMDA receptor subunit type 1 (NR1) expression during neuronal differentiation Academic Article
Effect on thermostability and catalytic activity of introducing disulfide bonds into aspergillus awamori glucoamylase Academic Article
Effector-dependent conformational-changes in protein kinase-c-gamma through epitope mapping with inhibitory monoclonal-antibodies Academic Article
Effects of blocking individual maturation cleavages in murine leukemia virus gag Academic Article
Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing Academic Article
Effects of interface mutations on association modes and electron-transfer rates between proteins Academic Article
Effects of polyvalent cations on the folding of an rRNA three-way junction and binding of ribosomal protein S15 Academic Article
Effects of transition metals on nitric oxide synthase catalysis Academic Article
Effects on bacillus-subtilis of a conditional-lethal mutation in the essential gtp-binding protein obg Academic Article
Efficacy of retinoids in IKZF1-mutated BCR-ABL1 acute lymphoblastic leukemia Academic Article
Efficient induction of fibrosarcomas by v-jun requires mutations in the DNA-binding region and the transactivation domain Academic Article
Efficient t cell activation via a toll-interleukin 1 receptor-independent pathway Academic Article
Efficient transformation of chicken embryo fibroblasts by c-jun requires structural modification in coding and noncoding sequences Academic Article
Elemental concentrations in the seed of mutants and natural variants of Arabidopsis thaliana grown under varying soil conditions Academic Article
Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression Academic Article
Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice Academic Article
Elucidation of DnaE as the antibacterial target of the natural product, nargenicin Academic Article
Emergent properties of proteostasis in managing cystic fibrosis Academic Article
Endogenous plasmin converts Glu-plasminogen to Lys-plasminogen on the monocytoid cell surface Academic Article
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus Academic Article
Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling Academic Article
Engineering Upper Hinge Improves Stability and Effector Function of a Human IgG1 Academic Article
Engineering complex riboswitch regulation by dual genetic selection Academic Article
Engineering naturally occurring trans-acting non-coding RNAs to sense molecular signals Academic Article
Engineering of substrate selectivity for tissue factor.Factor viia complex signaling through protease-activated receptor 2 Academic Article
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice Academic Article
Enhanced human-type receptor binding by ferret-transmissible H5N1 with a K193T mutation Academic Article
Enhanced major histocompatibility complex class i binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide Academic Article
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response Academic Article
Enrich: software for analysis of protein function by enrichment and depletion of variants Academic Article
Enrichment of sequencing targets from the human genome by solution hybridization Academic Article
Enzymatic detoxication, conformational selection, and the role of molten globule active sites Academic Article
Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila Academic Article
Epigenetic characterization of the fmr1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile x syndrome Academic Article
Epithelial membrane protein-1 is a biomarker of gefitinib resistance Academic Article
Ermc leader peptide - amino-acid sequence critical for induction by translational attenuation Academic Article
Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein Academic Article
Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone Academic Article
Essential function in vivo for dicer-2 in host defense against rna viruses in drosophila Academic Article
Essential glycine in the proton channel of escherichia coli transhydrogenase Academic Article
Establishment of cell-lines persistently infected with foot-and-mouth-disease virus Academic Article
Ethanolamine activates a sensor histidine kinase regulating its utilization in enterococcus faecalis Academic Article
Evaluation of the potential impact of Ebola virus genomic drift on the efficacy of sequence-based candidate therapeutics Academic Article
Evasion of the p53 tumour surveillance network by tumour-derived myc mutants Academic Article
Evidence for a unique first position codon-anticodon mismatch in vivo Academic Article
Evidence for an intermediate conformational state of lacy Academic Article
Evidence for distinct locations for metal binding sites in two closely related class I tRNA synthetases Academic Article
Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase Academic Article
Evidence that spooa mutations are recessive in spooa--spooa+ merodiploid strains of bacillus-subtilis Academic Article
Evolution in vitro of an RNA enzyme with altered metal dependence Academic Article
Evolution in vitro: analysis of a lineage of ribozymes Academic Article
Evolution of CXCR4-using human immunodeficiency virus type 1 SF162 is associated with two unique envelope mutations Academic Article
Evolution of broad spectrum β-lactam resistance in an engineered metallo-β-lactamase Academic Article
Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling Academic Article
Evolution of glutathione transferases and related enzymes for the protection of cells against electrophiles Academic Article
Evolution of proteins with genetically encoded "chemical warheads" Academic Article
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template Academic Article
Evolutionary analysis of HIV-1 protease inhibitors: methods for design of inhibitors that evade resistance Academic Article
Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme Academic Article
Examination of the transcription factor NtcA-binding motif by in vitro selection of DNA sequences from a random library Academic Article
Excess of rare amino acid polymorphisms in the toll-like receptor 4 in humans Academic Article
Exon 5 encoded domain is not required for the toxic function of mutant sod1 but essential for the dismutase activity: Identification and characterization of two new sod1 mutations associated with familial amyotrophic lateral sclerosis Academic Article
Exonuclease 1-dependent and independent mismatch repair Academic Article
Expanded host cell tropism and cytopathic properties of feline immunodeficiency virus strain ppr subsequent to passage through interleukin-2-independent t cells Academic Article
Expanding the genetic code of Escherichia coli Academic Article
Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the golgi apparatus Academic Article
Expression of t-cell receptor genes in an antigen-specific hybridoma and radiation-induced variants Academic Article
Expression of the lyst(beige) mutation is atheroprotective in chow-fed apolipoprotein e-deficient mice Academic Article
Expression, two-dimensional crystallization, and electron cryo-crystallography of recombinant gap junction membrane channels Academic Article
External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification Academic Article
F-box proteins FKF1 and LKP2 act in concert with ZEITLUPE to control Arabidopsis clock progression Academic Article
FAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formation Academic Article
FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis Academic Article
FKF1F-BOX protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis Academic Article
FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development Academic Article
FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions Academic Article
Failure of hairpin-ended and nicked DNA to activate DNA-dependent protein kinase: Implications for V(D)J recombination Academic Article
Failure to cleave measles-virus fusion protein in lymphoid-cells - a possible mechanism for viral persistence in lymphocytes Academic Article
Far1 is required for posttranscriptional regulation of cln2 gene-expression in response to mating pheromone Academic Article
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation Academic Article
Fast folding mutants of the Tetrahymena group I ribozyme reveal a rugged folding energy landscape Academic Article
Fatal hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection in a patient with a novel mutation in the signaling lymphocytic activation molecule-associated protein Academic Article
Fbxw7/hcdc4 is a general tumor suppressor in human cancer Academic Article
Features of subunit nuom (nd4) in escherichia coli ndh-1 topology and implication of conserved glu(144) for coupling site 1 Academic Article
Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans Academic Article
Filopodia are required for cortical neurite initiation Academic Article
Fimbrin phosphorylation by metaphase Cdk1 regulates actin cable dynamics in budding yeast Academic Article
Fine definition of the CXCR4-binding region on the V3 loop of feline immunodeficiency virus surface glycoprotein Academic Article
Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region Academic Article
Fixation of mutations in the viral genome during an outbreak of foot-and-mouth-disease - heterogeneity and rate variations Academic Article
Flower arranging in Arabidopsis Academic Article
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells Academic Article
Fluorescence turn-on folding sensor to monitor proteome stress in live cells Academic Article
Fluorotryptophan incorporation modulates the structure and stability of transthyretin in a site-specific manner Academic Article
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing Academic Article
Folding and particle assembly are disrupted by single-point mutations near the autocatalytic cleavage site of nudaurelia capensis omega virus capsid protein Academic Article
Folding of fibroblast growth factor 1 is critical for its nonclassical release Academic Article
Formation of a chloride-conducting state in the maltose ATP-binding cassette (ABC) transporter Academic Article
Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1 Academic Article
Formation of gelsolin amyloid fibrils in the rough endoplasmic reticulum of skeletal muscle in the gelsolin mouse model of inclusion body myositis: comparative analysis to human sporadic inclusion body myositis Academic Article
Formation of trans-activation competent hiv-1 rev:Rre complexes requires the recruitment of multiple protein activation domains Academic Article
Forward genetics by sequencing EMS variation-induced inbred lines Academic Article
Fragile T-stem in disease-associated human mitochondrial tRNA sensitizes structure to local and distant mutations Academic Article
Frequency and genetic background of the position 122(val-Ile) variant transthyretin gene in the black-population Academic Article
Full-length archaeal rad51 structure and mutants: Mechanisms for rad51 assembly and control by brca2 Academic Article
Function of the activated protein c (apc) autolysis loop in activated fviii inactivation Academic Article
Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase Academic Article
Functional characterization of multiple DICER1 mutations in an adolescent Academic Article
Functional characterization of ttnd and ttnf, unveiling new insights into tautomycetin biosynthesis Academic Article
Functional defects of pathogenic human mitochondrial tRNAs related to structural fragility Academic Article
Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3 Academic Article
Functional roles of four conserved charged residues in the membrane domain subunit nuoa of the proton-translocating nadh-quinone oxidoreductase from escherichia coli Academic Article
Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex Academic Article
Functional-analysis of the human tissue factor promoter and induction by serum Academic Article
Functionally diverging molecular quasi-species evolve by crossing two enzymes Academic Article
Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor Academic Article
Further evidence for association of grk3 to bipolar disorder suggests a second disease mutation Academic Article
Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein e2c direct integration of viral DNA into specific sites Academic Article
G-protein mutations that alter the pheromone response in saccharomyces-cerevisiae Academic Article
GIGANTEA directly activates Flowering Locus T in Arabidopsis thaliana Academic Article
GTPase traffic control Academic Article
GUN4, a regulator of chlorophyll synthesis and intracellular signaling Academic Article
Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B Academic Article
Gain-of-function mutational activation of human tRNA synthetase procytokine Academic Article
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis Academic Article
Galactolipid deficiency and abnormal chloroplast development in the Arabidopsis MGD synthase 1 mutant Academic Article
Galanin overexpressing transgenic mice Academic Article
Gap junction channel structure in the early 21st century: Facts and fantasies Academic Article
Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles Academic Article
Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR) Academic Article
Gene therapy for chronic viral hepatitis: ribozymes, antisense oligonucleotides, and dominant negative mutants Academic Article
Gene-enzyme relationships of aromatic acid biosynthesis in bacillus-subtilis Academic Article
Generation of a Ni(II) binding site by introduction of a histidine cluster in the structure of human glutathione transferase A1-1 Academic Article
Generation of a catalytic antibody by site-directed mutagenesis Academic Article
Generation of a catalytic sequence-specific hybrid DNase Academic Article
Generation of a hybrid sequence-specific single-stranded deoxyribonuclease Academic Article
Generation of mutation hotspots in ageing bacterial colonies Academic Article
Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration Academic Article
Genetic ablation of a mouse gene expressed specifically in brain Academic Article
Genetic abnormalities and juvenile hemochromatosis: Mutations of the hjv gene encoding hemojuvelin Academic Article
Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines Academic Article
Genetic analysis of cyclic nucleotide phosphodiesterases in Drosophila melanogaster Academic Article
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large Academic Article
Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles Academic Article
Genetic analysis of innate immunity: Identification and function of the tir adapter proteins Academic Article
Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV) Academic Article
Genetic analysis of pleiotropic negative sporulation mutants in bacillus subtilis Academic Article
Genetic analysis of resistance to viral infection Academic Article
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis Academic Article
Genetic and biochemical characterization of mutants of bacillus-subtilis defective in succinate dehydrogenase Academic Article
Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development Academic Article
Genetic basis of tetrodotoxin resistance in pufferfishes Academic Article
Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases Academic Article
Genetic disorders associated with atp binding cassette cholesterol transporters Academic Article
Genetic dissection of innate immunity to infection: The mouse cytomegalovirus model Academic Article
Genetic diversity of EBV-encoded LMP1 in the Swiss HIV Cohort Study and implication for NF-Κb activation Academic Article
Genetic incorporation of histidine derivatives using an engineered pyrrolysyl-tRNA synthetase Academic Article
Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis Academic Article
Genetic interaction landscape reveals critical requirements for Schizosaccharomyces pombe Brc1 in DNA damage response mutants Academic Article
Genetic interactions between phytochrome A, phytochrome B, and cryptochrome 1 during Arabidopsis development Academic Article
Genetic localization and molecular characterization of the nons gene required for macrotetrolide biosynthesis in streptomyces griseus dsm40695 Academic Article
Genetic mutations in ten unrelated american patients with symptomatic type-1 protein-C deficiency Academic Article
Genetic recombinants and heterozygotes derived from endogenous and exogenous avian RNA tumor viruses Academic Article
Genetic screening for low-penetrance variants in protein-coding genes Academic Article
Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300 Academic Article
Genetic variation in an individual human exome Academic Article
Genetic-analysis in bacillus-subtilis Academic Article
Genetic-analysis of a class of polymyxin resistant partial revertants of stage-o sporulation mutants of bacillus-subtilis - map of the chromosome region near the origin of replication Academic Article
Genetic-mapping of a linked cluster of ribosomal ribonucleic-acid genes in bacillus-subtilis Academic Article
Genetically engineered polymers of human Cu Zn superoxide-dismutase - biochemistry and serum half-lives Academic Article
Genetics of alpha-ketoglutarate dehydrogenase complex of bacillus-subtilis Academic Article
Genetics of bacillus-subtilis chemotaxis - isolation and mapping of mutations and cloning of chemotaxis genes Academic Article
Genetics of bacterial sporulation Academic Article
Genome-wide association study identifies five new schizophrenia loci Academic Article
Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior Academic Article
Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome Academic Article
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma Academic Article
Genomic sequence of the dax1 gene: An orphan nuclear receptor responsible for x-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism Academic Article
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak Academic Article
Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila Academic Article
Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates alzheimer's disease-related neuropathies: Involvement of non-amyloidogenic processing Academic Article
Global aggregation of newly translated proteins in an Escherichia coli strain deficient of the chaperonin GroEL Academic Article
Global analysis of protein palmitoylation in yeast Academic Article
Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer Academic Article
Glutathione precursors replenish decreased glutathione pool in cystinotic cell lines Academic Article
Glutathione transferase A1-1: catalytic importance of arginine 15 Academic Article
Glutathione transferase P1-1 expression in human melanoma metastases: correlation to N-RAS mutations and expression Academic Article
Glutathione transferases with novel active sites isolated by phage display from a library of random mutants Academic Article
Glycine substitutions in collagen heterotrimers alter triple helical assembly Academic Article
Glycolipids of chick-embryo fibroblasts infected with temperature-sensitive mutants of avian-sarcoma viruses Academic Article
Glycoproteins of plasma-membrane of dictyostelium discoideum during development Academic Article
Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts Academic Article
Growth-related alterations induced in chick embryo fibroblasts by src-gene deletion mutants of the schmidt-ruppin strain of rous sarcoma virus Academic Article
H-nox-mediated nitric oxide sensing modulates symbiotic colonization by vibrio fischeri Academic Article
H7N9 influenza virus neutralizing antibodies that possess few somatic mutations Academic Article
HCV core residues critical for infectivity are also involved in core-NS5A complex formation Academic Article
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogene Academic Article
HIV-1 entry and macrophage inflammatory protein-1 beta-mediated signaling are independent functions of the chemokine receptor CCR5 Academic Article
Haematological effects of the c282yhfe mutation in homozygous and heterozygous states among subjects of northern and southern european ancestry Academic Article
Haemolytic onset of Wilson disease in a patient with homozygous truncation of ATP7B at Arg1319 Academic Article
Haptoglobin polymorphism and iron homeostasis Academic Article
Harmonin mutations cause mechanotransduction defects in cochlear hair cells Academic Article
Hcdc4 gene mutations in endometrial cancer Academic Article
Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores Academic Article
Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli Academic Article
Helical crystallization on lipid nanotubes: Streptavidin as a model protein Academic Article
Helical crystallization on nickel–lipid nanotubes: Perfringolysin O as a model protein Academic Article
Helical domain and kinase domain mutations in p110 alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms Academic Article
Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins b cell linker protein and slp-76 in lymphocytes Academic Article
Heme synthesis by plastid ferrochelatase I regulates nuclear gene expression in plants Academic Article
Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection Academic Article
Hepatitis B virus mutants: clinical significance for diagnosis and therapy Academic Article
Heregulin-ErbB3-driven tumor growth persists in PI3 kinase mutant cancer cells Academic Article
Herpes simplex virus encephalitis in human unc-93b deficiency Academic Article
Herpesviruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract Academic Article
High prevalence of the very rare wilson disease gene mutation leu708pro in the island of gran canaria (canary islands, spain): A genetic and clinical study Academic Article
High prion and prpsc levels but delayed-onset of disease in scrapie-inoculated mice heterozygous for a disrupted prp gene Academic Article
High-resolution definition of vaccine-elicited b cell responses against the hiv primary receptor binding site Academic Article
High-resolution mapping of the folding transition state of a WW domain Academic Article
High-resolution mutational profiling suggests the genetic validity of glioblastoma patient-derived pre-clinical models Academic Article
High-resolution structure of a protein spin-label in a solvent-exposed β-sheet and comparison with DEER spectroscopy Academic Article
High-throughput screening methodology for the directed evolution of glycosyltransferases Academic Article
High-yield reassortant influenza vaccine production virus has a mutation at an hla-a 2.1-restricted cd8(+) ctl epitope on the ns1 protein Academic Article
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast Academic Article
Histone H3 Thr 45 phosphorylation is a replication-associated post-translational modification in S. cerevisiae Academic Article
Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast Academic Article
Histone H3 lysine 56 acetylation and the response to DNA replication fork damage Academic Article
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription Academic Article
Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of alpha 1-antitrypsin deficiency Academic Article
Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana Academic Article
Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks Academic Article
Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast Academic Article
Hiv-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins Academic Article
Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix Academic Article
Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation Academic Article
Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS Academic Article
How a mutation that slows aging can Also disproportionately extend end-of-life decrepitude Academic Article
Hsc70 is required for endocytosis and clathrin function in drosophila Academic Article
Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex Academic Article
Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe Academic Article
Human f-box protein hcdc4 targets cyclin e for proteolysis and is mutated in a breast cancer cell line Academic Article
Human fc-gamma-ri and fc-gamma-rii interact with distinct but overlapping sites on human-igg Academic Article
Human germline antibody gene segments encode polyspecific antibodies Academic Article
Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2 Academic Article
Human immunodeficiency virus type 1 coreceptor switching: V1/V2 gain-of-fitness mutations compensate for V3 loss-of-fitness mutations Academic Article
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations Academic Article
Human protein n-terminal acetyltransferase hnaa50p (hnat5/hsan) follows ordered sequential catalytic mechanism combined kinetic and NMR study Academic Article
Human rhinovirus capsid dynamics is controlled by canyon flexibility Academic Article
Human, viral or mutant human il-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis Academic Article
Humanized IgG(1) variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates Academic Article
Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease Academic Article
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant Academic Article
Hyperglycosylated mutants of human immunodeficiency virus (hiv) type 1 monomeric gp120 as novel antigens for hiv vaccine design Academic Article
Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype Academic Article
Hyperprotease-producing mutants of bacillus subtilis Academic Article
Hypocretins/orexins as integrators of physiological information: Lessons from mutant animals Academic Article
Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner Academic Article
IRhom2 is required for the secretion of mouse TNFα Academic Article
Icosahedral virus particles as addressable nanoscale building blocks Academic Article
Identification and characterization of a novel cell-penetrating peptide Academic Article
Identification and characterization of single chain anti-cocaine catalytic antibodies Academic Article
Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor Academic Article
Identification of Asp(174) and Asp(175) as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants Academic Article
Identification of Ppk26, a DEG/ENaC channel functioning with Ppk1 in a mutually dependent manner to guide locomotion behavior in Drosophila Academic Article
Identification of a cdk-activating kinase in fission yeast Academic Article
Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor Academic Article
Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast Academic Article
Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor Academic Article
Identification of alk as a major familial neuroblastoma predisposition gene Academic Article
Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and lassa fever virus Academic Article
Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus Academic Article
Identification of evening complex associated proteins in Arabidopsis by affinity purification and mass spectrometry Academic Article
Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine Academic Article
Identification of four novel mutations in F5 associated with congenital factor V deficiency Academic Article
Identification of genes controlling growth polarity in the budding yeast saccharomyces cerevisiae: A possible role of n-glycosylation and involvement of the exocyst complex Academic Article
Identification of ginsenoside interaction sites in 5-ht3a receptors Academic Article
Identification of lps2 as a key transducer of myd88-independent tir signalling Academic Article
Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach Academic Article
Identification of open stomatal-interacting proteins reveals interactions with sucrose non-fermenting1-related protein kinases2 and with type 2A protein phosphatases that function in abscisic acid responses Academic Article
Identification of pathways controlling DNA damage induced mutation in saccharomyces cerevisiae Academic Article
Identification of rare cancer driver mutations by network reconstruction Academic Article
Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor viia Academic Article
Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis Academic Article
Identification of the first synthetic steroidogenic factor 1 inverse agonists: Pharmacological modulation of steroidogenic enzymes Academic Article
Identification of the transcriptional suppressor sof-1 as an alteration in the spo0a protein Academic Article
Identification of the zinc ligands in cobalamin-independent methionine synthase (MetE) from Escherichia coli Academic Article
Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding Academic Article
Identification of viral mutants by mass spectrometry Academic Article
Identifying recent adaptations in large-scale genomic data Academic Article
Identifying safety concerns from genetic data: lessons from the development of CCR5 inhibitors Academic Article
Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins Academic Article
Immune response to cyclin B1 in hepatocellular carcinoma Academic Article
Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice Academic Article
Immunofocusing: Antigen engineering to promote the induction of hiv-neutralizing antibodies Academic Article
Immunological origins of binding and catalysis in a Diels-Alderase antibody Academic Article
Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay Academic Article
Immunosuppressive and autoimmune effects of thimerosal in mice Academic Article
Impact of mutations on the higher order structure and activity of a recombinant uricase Academic Article
Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function Academic Article
Impact of somatic mutation on the S107(T15) heavy-chain V region of antibodies reactive with self and nonself Academic Article
Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia Academic Article
Impaired clock output by altered connectivity in the circadian network Academic Article
Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases Academic Article
Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor Academic Article
Implication of a novel multiprotein Dam1p complex in outer kinetochore function Academic Article
Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation Academic Article
Importance of single molecular determinants in the fidelity of expanded genetic codes Academic Article
Improved breadth and potency of an hiv-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning Academic Article
Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant Academic Article
Improved identification of SUMO attachment sites using C-terminal SUMO mutants and tailored protease digestion strategies Academic Article
In silico screening against wild-type and mutant Plasmodium falciparum dihydrofolate reductase Academic Article
In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer Academic Article
In vitro evolution of a ribozyme that contains 5-bromouridine Academic Article
In vitro evolution of h5n1 avian influenza virus toward human-type receptor specificity Academic Article
In vitro selection of state-specific peptide modulators of G protein signaling using mRNA display Academic Article
In vitro site-directed mutagenesis: generation and properties of an infectious extracistronic mutant of bacteriophage Qbeta Academic Article
In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons Academic Article
In vivo incorporation of an alkyne into proteins in Escherichia coli Academic Article
In vivo manipulation of the bleomycin biosynthetic gene cluster in streptomyces verticillus atcc15003 revealing new insights into its biosynthetic pathway Academic Article
In vivo molecular evolution reveals biophysical origins of organismal fitness Academic Article
In vivo selection for the directed evolution of l-rhamnulose aldolase from l-rhamnulose-1-phosphate aldolase (rhad) Academic Article
In vivo study of the HC-TN strain of hepatitis C virus recovered from a patient with fulminant hepatitis: RNA transcripts of a molecular clone (pHC-TN) are infectious in chimpanzees but not in Huh7.5 cells Academic Article
Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage Academic Article
Increased functional stability and homogeneity of viral envelope spikes through directed evolution Academic Article
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice Academic Article
Increased lipid accumulation in the Chlamydomonas reinhardtii sta7-10 starchless isoamylase mutant and increased carbohydrate synthesis in complemented strains Academic Article
Increased mutation frequency of feline immunodeficiency virus lacking functional deoxyuridine-triphosphatase Academic Article
Increased susceptibility to DNA virus infection in mice with a GCN2 mutation Academic Article
Induced genome instability as a potential screening test for cancer susceptibility? Academic Article
Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis Academic Article
Induction and inhibition of ciprofloxacin resistance-conferring mutations in hypermutator bacteria Academic Article
Induction of a cellular enzyme for energy metabolism by transforming domains of adenovirus E1a Academic Article
Induction of positive cooperativity by amino acid replacements within the C-terminal domain of penicillium chrysogenum ATP sulfurylase Academic Article
Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes Academic Article
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity Academic Article
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger Academic Article
Influence of hPin1 WWN-terminal domain boundaries on function, protein stability, and folding Academic Article
Influence of mutations in tissue factor on the fine specificity of macromolecular substrate activation Academic Article
Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity Academic Article
Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic acid receptors Academic Article
Influenza virus-susceptible mice carry mx-genes with a large deletion or a nonsense mutation Academic Article
Inhibition of mutation and combating the evolution of antibiotic resistance Academic Article
Inhibition of viral replication by genetically engineered mutants of the duck hepatitis B virus core protein Academic Article
Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers Academic Article
Inorganic pyrophosphate (PPI) in pathologic calcification of articular cartilage Academic Article
Insertion of new sequences into the catalytic domain of an enzyme Academic Article
Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase Academic Article
Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations Academic Article
Insights into the molecular recognition of the 5 '-gnn-3 ' family of DNA sequences by zinc finger domains Academic Article
Interaction interface of human flap endonuclease-1 with its DNA substrates Academic Article
Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein Academic Article
Interaction of sp-a (surfactant protein a) with bacterial rough lipopolysaccharide (re-lps), and effects of sp-a on the binding of re-lps to cd14 and lps-binding protein Academic Article
Interaction of the Bacillus stearothermophilus ribosomal protein S15 with its 5 '-translational operator mRNA Academic Article
Interaction surface of the spo0a response regulator with the spo0e phosphatase Academic Article
Interactions between hy1 and gun mutants of Arabidopsis, and their implications for plastid/nuclear signalling Academic Article
Intercellular coupling confers robustness against mutations in the SCN circadian clock network Academic Article
Interfering with resistance to Smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma Academic Article
Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice Academic Article
Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue Academic Article
Internal structural features of E. coli glycyl-tRNA synthetase examined by subunit polypeptide chain fusions Academic Article
Internalization and vacuolar targeting of the brassinosteroid hormone receptor BRI1 are regulated by ubiquitination Academic Article
Intersection between the regulators of sister chromatid cohesion establishment and maintenance in budding yeast indicates a multi-step mechanism Academic Article
Interstice mutations that block site-to-site translocation of a misactivated amino acid bound to a class I tRNA synthetase Academic Article
Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants Academic Article
Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase Academic Article
Invariant NKT cells require autophagy to coordinate proliferation and survival signals during differentiation Academic Article
Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants Academic Article
Investigation of the mechanism of resistance to third-generation cephalosporins by class C beta-lactamases by using chemical complementation Academic Article
Investor Outlook: Focus on upcoming LCA2 gene therapy phase III results Academic Article
Involvement of the lamin rod domain in heterotypic lamin interactions important for nuclear organization Academic Article
Iron overload and prolonged ingestion of iron supplements: Clinical features and mutation analysis of hemochromatosis-associated genes in four cases Academic Article
Iron overload secondary to cirrhosis: a mimic of hereditary haemochromatosis? Academic Article
Iron-sulfur cluster n5 is coordinated by an hxxxcxxcxxxxxc motif in the nuog subunit of escherichia coli nadh : Quinone oxidoreductase (complex i) Academic Article
Is sequence conservation in interferons due to selection for functional proteins Academic Article
Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention Academic Article
Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1 alpha transcription Academic Article
Isolation and characterization of 2 genes encoding yeast mating pheromone signaling elements - cdc72 and cdc73 Academic Article
Isolation and structural elucidation of tetracenomycin-f2 and tetracenomycin-f1 - early intermediates in the biosynthesis of tetracenomycin-c in streptomyces-glaucescens Academic Article
Isolation of highly malignant Thy-1-positive revertants from cultured cloned Thy-1-negative lymphoma-cells of low tumorigenicity Academic Article
Isolation of timeless by per protein-interaction - defective interaction between timeless protein and long-period mutant per(l) Academic Article
Isomerization of Δ5-androstene-3,17-dione into Δ4-androstene-3,17-dione catalyzed by human glutathione transferase A3-3: a computational study identifies a dual role for glutathione Academic Article
JLK isocoumarin inhibitors: Selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo Academic Article
Jinx, an mcmv susceptibility phenotype caused by disruption of unc13d: A mouse model of type 3 familial hemophagocytic lymphohistiocytosis Academic Article
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress Academic Article
Jun inhibits myogenic differentiation Academic Article
Jun, the oncoprotein Academic Article
K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling Academic Article
Kap121p-mediated nuclear import is required for mating and cellular differentiation in yeast Academic Article
Kinase mutations in human disease: Interpreting genotype-phenotype relationships Academic Article
Kinetic intermediates trapped by native interactions in RNA folding Academic Article
Kinetic properties of missense mutations in patients with glutathione synthetase deficiency Academic Article
Kinetics and thermodynamics make different contributions to RNA folding in vitro and in yeast Academic Article
Kinetics of hairpin ribozyme cleavage in yeast Academic Article
Kinetochore biorientation in Saccharomyces cerevisiae requires a tightly folded conformation of the Ndc80 complex Academic Article
Knock-in mice reveal nonsense-mediated mRNA decay in the brain Academic Article
Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants Academic Article
Label transfer chemistry for the characterization of protein-protein interactions Academic Article
Lac repressor genetic map in real space Academic Article
Lack of complex i activity in human cells carrying a mutation in mtdna-encoded nd4 subunit is corrected by the saccharomyces cerevisiae nadh-quinone oxidoreductase (ndi1) gene Academic Article
Large scale mutational and kinetic analysis of a self-hydrolyzing deoxyribozyme Academic Article
Late onset thrombosis in a case of severe protein S deficiency due to compound heterozygosity for PROS1 mutations Academic Article
Learning performance of normal and mutant Drosophila after repeated conditioning trials with discrete stimuli Academic Article
Leu628 of the kix domain of cbp is a key residue for the interaction with the mll transactivation domain Academic Article
Levels of RNA from a family of putative serine protease genes are reduced in Drosophila melanogaster dunce mutants and are regulated by cyclic AMP Academic Article
Ligand-induced conformational changes in the bacillus subtilis chemoreceptor mcpb determined by disulfide crosslinking in vivo Academic Article
Light activation of the LOV protein Vivid generates a rapidly exchanging dimer Academic Article
Light signals in leaf and chloroplast development: photoreceptors and downstream responses in search of a transduction pathway Academic Article
Light-dependent sequestration of TIMELESS by CRYPTOCHROME Academic Article
Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast Academic Article
Linking photoreceptor excitation to changes in plant architecture Academic Article
Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan Academic Article
Lipophilic regulator of a developmental switch in Caenorhabditis elegans Academic Article
Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway Academic Article
Localization and substrate selectivity of sea urchin multidrug (MDR) efflux transporters Academic Article
Location and architecture of the Caulobacter crescentus chemoreceptor array Academic Article
Location of the targets of the hpr-97, sacu32(hy), and sacq36(hy) mutations in upstream regions of the subtilisin promoter Academic Article
Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling Academic Article
Long-range effects and functional consequences of stabilizing mutations in the ankyrin repeat domain of IκBα Academic Article
Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase Academic Article
Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy Academic Article
Long-term persistent vesicular stomatitis-virus and rabies virus-infection of cells in vitro Academic Article
Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts Academic Article
Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock Academic Article
Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope Academic Article
Loss of sex discrimination and male-male aggression in mice deficient for trp2 Academic Article
Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer Academic Article
Loss-of-function mutation in myostatin reduces tumor necrosis factor alpha production and protects liver against obesity-induced insulin resistance Academic Article
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease Academic Article
Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller Academic Article
Lpr t-cell hyporesponsiveness to mitogens linked to deficient receptor-stimulated phosphoinositide hydrolysis Academic Article
Lys(842) in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer Academic Article
Macaque long-term nonprogressors resist superinfection with multiple cd8(+) t cell escape variants of simian immunodeficiency virus Academic Article
Mafa has strong cell transforming ability but is a weak transactivator Academic Article
Maintenance of genome stability in Saccharomyces cerevisiae Academic Article
Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells Academic Article
Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck Academic Article
Map2 and tau bind longitudinally along the outer ridges of microtubule protofilaments Academic Article
Mapkk-independent activation of p38 alpha mediated by tab1-dependent autophosphorylation of p38 alpha Academic Article
Mapping rnase t1-resistant oligonucleotides of avian tumor virus rnas: Sarcoma-specific oligonucleotides are near the poly(a) end and oligonucleotides common to sarcoma and transformation-defective viruses are at the poly(a) end Academic Article
Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo Academic Article
Mapping the transition state of the WW domain beta-sheet Academic Article
Massively parallel functional analysis of BRCA1 RING domain variants Academic Article
Maturation of shark single-domain (ignar) antibodies: Evidence for induced-fit binding Academic Article
Mcd4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast Academic Article
Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade Academic Article
Measuring food intake and nutrient absorption in Caenorhabditis elegans Academic Article
Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, polynucleotide kinase Academic Article
Mechanism of activation of protein kinase JAK2 by the growth hormone receptor Academic Article
Mechanism of human antibody-mediated neutralization of Marburg virus Academic Article
Mechanism of transfection with deoxyribonucleic acid from temperate bacillus bacteriophage phi105 Academic Article
Mechanism-based post-translational modification and inactivation in terpene synthases Academic Article
Mechanisms of escape from the PGT128 family of anti-HIV broadly neutralizing antibodies Academic Article
Mechanisms underlying hypoxia tolerance in drosophila melanogaster: Hairy as a metabolic switch Academic Article
Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations Academic Article
Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides Academic Article
Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase Academic Article
Mechanistic properties of immunoglobulin somatic mutation Academic Article
Melanopsin-encoded response properties of intrinsically photosensitive retinal ganglion cells Academic Article
Melting of a DNA helix terminus within the active-site of a DNA-polymerase Academic Article
Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization Academic Article
Metal-binding 'finger' structures in the glucocorticoid receptor defined by site-directed mutagenesis Academic Article
Metastatic carcinomatous cirrhosis and hepatic hemosiderosis Academic Article
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function Academic Article
Microbial source tracking by DNA sequence analysis of the Escherichia coli malate dehydrogenase gene Academic Article
Microdroplet-based pcr enrichment for large-scale targeted sequencing Academic Article
Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features Academic Article
Misexpression of the eyes absent family triggers the apoptotic program Academic Article
Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients Academic Article
Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication Academic Article
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction Academic Article
Mitochondrial fission in apoptosis, neurodegeneration and aging Academic Article
Mitotic misregulation and human aging Academic Article
Mitotic role for the cdc28-protein kinase of saccharomyces-cerevisiae Academic Article
Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe Academic Article
Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control Academic Article
Modeling the evolution of drug resistance in malaria Academic Article
Modeling the inhibition of quadruple mutant Plasmodium falciparum dihydrofolate reductase by pyrimethamine derivatives Academic Article
Modeling with in vitro kinetic parameters for the elaboration of transfer RNA identity in vivo Academic Article
Modification of porous protein crystals in development of biohybrid materials Academic Article
Modulation of HIF-2α PAS-B domain contributes to physiological responses Academic Article
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ib-alpha Academic Article
Modulation of brassinosteroid-regulated gene expression by jumonji domain-containing proteins ELF6 and REF6 in Arabidopsis Academic Article
Modulation of fluorescent protein chromophores to detect protein aggregation with turn-on fluorescence Academic Article
Modulation of rac localization and function by dynamin Academic Article
Modulation of substrate specificities of D-sialic acid aldolase through single mutations of Val-251 Academic Article
Modulation of the SecY channel permeability by pore mutations and trivalent cations Academic Article
Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control Academic Article
Molecular basis of seasonal time measurement in Arabidopsis Academic Article
Molecular basis of viral persistence: a single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence Academic Article
Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C Academic Article
Molecular characterization of single memory b-cells Academic Article
Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions Academic Article
Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo - Rab-independent binding to membranes and role of Rab recycling factors Academic Article
Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents Academic Article
Molecular evolution of the Rab-escort-protein/guanine-nucleotide-dissociation-inhibitor superfamily Academic Article
Molecular genetics of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency Academic Article
Molecular genetics of transmissible spongiform encephalopathies Academic Article
Molecular mechanism of the sweet taste enhancers Academic Article
Molecular mechanisms of myocardial infarction Academic Article
Molecular methods for isolation of signal transduction pathway mutants Academic Article
Molecular pathogenesis of cystinosis: Effect of ctns mutations on the transport activity and subcellular localization of cystinosin Academic Article
Molecular role for the Rab binding platform of guanine nucleotide dissociation inhibitor in endoplasmic reticulum to Golgi transport Academic Article
Molecular-biology approaches to genetic-defects of the mammalian nervous-system Academic Article
Molecular-cloning of bacillus-subtilis genes involved in DNA metabolism Academic Article
Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor Academic Article
Monoclonal anti-H-2Kb antibodies detect serological differences between H-2Kb mutants Academic Article
Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor Academic Article
Mouse hematopoietic stem-cells Academic Article
Mouse hematopoietic stem-cells and the interaction of c-kit receptor and steel factor Academic Article
Mouse model of subretinal neovascularization with choroidal anastomosis Academic Article
Mps1 phosphorylation of Dam1 couples kinetochores to microtubule plus ends at metaphase Academic Article
Mps1Mph1 kinase phosphorylates Mad3 to inhibit Cdc20Slp1-APC/C and maintain spindle checkpoint arrests Academic Article
Mss4 does not function as an exchange factor for Rab in endoplasmic reticulum to Golgi transport Academic Article
Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration Academic Article
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence Academic Article
Multi-substrate-activity space and quasi-species in enzyme evolution: Ohno's dilemma, promiscuity and functional orthogonality Academic Article
Multidimensional epistasis and fitness landscapes in enzyme evolution Academic Article
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair Academic Article
Multiple histidine kinases regulate entry into stationary phase and sporulation in bacillus subtilis Academic Article
Multiple large filament bundles observed in Caulobacter crescentus by electron cryotomography Academic Article
Multiple mutations in hepatitis C virus NS5A domain II are required to confer a significant level of resistance to alisporivir Academic Article
Multiple new genes that determine activity for the first step of leucine biosynthesis in Saccharomyces cerevisiae Academic Article
Multiple pathways for suppression of mutants affecting g(1)-specific tip transcription in saccharomyces cerevisiae Academic Article
Multiple protein aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in bacillus-subtilis Academic Article
Multiple sites on IL-8 responsible for binding to alpha and beta IL-8 receptors Academic Article
Multiple topogenic sequences in bovine opsin Academic Article
Multivalent minigene vaccines against infectious disease Academic Article
Multivariate-activity mining for molecular quasi-species in a glutathione transferase mutant library Academic Article
Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model Academic Article
Mushroom bodies and Drosophila learning Academic Article
Mutability of prions Academic Article
Mutagenesis by retroviral insertion in chemical mutagen-gene rated quasi-haploid mammalian cells Academic Article
Mutagenesis of mouse myeloma cells with Melphalan Academic Article
Mutagenesis-mediated virus extinction: Virus-dependent effect of viral load on sensitivity to lethal defection Academic Article
Mutant aminoacyl-tRNA synthetase that compensates for a mutation in the major identity determinant of its tRNA Academic Article
Mutants of 4-oxalocrotonate tautomerase catalyze the decarboxylation of oxaloacetate through an imine mechanism Academic Article
Mutants of dictyostelium-discoideum blocked in expression of all members of the developmentally regulated discoidin multigene family Academic Article
Mutated pi 3-kinases: Cancer targets on a silver platter Academic Article
Mutating a highly conserved residue in diverse cytochrome P450s facilitates diastereoselective olefin cyclopropanation Academic Article
Mutation altering the function of a carbohydrate binding-protein blocks cell-cell cohesion in developing dictyostelium-discoideum Academic Article
Mutation analysis in hereditary hemochromatosis Academic Article
Mutation analysis of the HBB gene in selected Bangladeshi beta-thalassemic individuals: presence of rare mutations Academic Article
Mutation and selection of prions Academic Article
Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice Academic Article
Mutation of hcdc4 leads to cell cycle deregulation of cyclin e in cancer Academic Article
Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection Academic Article
Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis Academic Article
Mutational activation of c-raf-1 and definition of the minimal transforming sequence Academic Article
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction Academic Article
Mutational analysis of 48G7 reveals that somatic hypermutation affects both antibody stability and binding affinity Academic Article
Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay Academic Article
Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine Academic Article
Mutational analysis of ligand-binding activity of beta-2 adrenergic-receptor expressed in escherichia-coli Academic Article
Mutational analysis of membrane and soluble forms of human md-2 Academic Article
Mutational analysis of phosphodiesterase in Drosophila Academic Article
Mutational analysis of sulfite reductase hemoprotein reveals the mechanism for coordinated electron and proton transfer Academic Article
Mutational analysis of the Arabidopsis nucleotide binding site-leucine-rich repeat resistance gene RPS2 Academic Article
Mutational isolation of a sieve for editing in a transfer RNA synthetase Academic Article
Mutational separation of aminoacylation and cytokine activities of human tyrosyl-tRNA synthetase Academic Article
Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction Academic Article
Mutationally derived H-2 antigenic differences as defined by cytolytic T lymphocyte clones Academic Article
Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans Academic Article
Mutations in GDI1 are responsible for X-linked non-specific mental retardation Academic Article
Mutations in GNAL cause primary torsion dystonia Academic Article
Mutations in GNAL: a novel cause of craniocervical dystonia Academic Article
Mutations in NR4A2 associated with familial Parkinson disease Academic Article
Mutations in a gene encoding the alpha-subunit of a saccharomyces-cerevisiae g-protein indicate a role in mating pheromone signaling Academic Article
Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells Academic Article
Mutations in cell-division cycle genes cdc36 and cdc39 activate the saccharomyces-cerevisiae mating pheromone response pathway Academic Article
Mutations in human dynamin block an intermediate stage in coated vesicle formation Academic Article
Mutations in the hfe gene and cardiovascular disease risk an individual patient data meta-analysis of 53 880 subjects Academic Article
Mutations in the regulatory domain of phenylalanine hydroxylase and response to tetrahydrobiopterin Academic Article
Mutations that affect dimer formation and helicase activity of the hepatitis C virus helicase Academic Article
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands Academic Article
Myc rescue of a mutant csf-1 receptor impaired in mitogenic signaling Academic Article
Myc signaling via the arf tumor suppressor regulates p53-dependent apoptosis and immortalization Academic Article
Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by e2f1 loss Academic Article
Myelin-associated glycoprotein (mag) and rat brain-specific 1b236-protein - mapping of epitopes and demonstration of immunological identity Academic Article
Myocyte protection by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of the Ras GTP-ase pathway Academic Article
Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 map kinase Academic Article
Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles Academic Article
Myristoylation of the RING finger Z protein is essential for arenavirus budding Academic Article
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans Academic Article
N-glycosylation is essential for vesicular targeting of synaptotagmin 1 Academic Article
N-myristoylation is required for function of the pheromone-responsive g-alpha protein of yeast - conditional activation of the pheromone response by a temperature-sensitive n-myristoyl transferase Academic Article
NF kappa B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Academic Article
NHE8 is essential for RPE cell polarity and photoreceptor survival Academic Article
Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials Academic Article
Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells Academic Article
Naturally death-resistant precursor cells revealed as the origin of retinoblastoma Academic Article
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair Academic Article
Negative regulation of g(1) and g(2) by s-phase cyclins of saccharomyces cerevisine Academic Article
Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2 Academic Article
Negative regulation of human c-fos expression by the retinoblastoma gene-product Academic Article
Negative regulation of yeast Eps15-like Arp2/3 complex activator, Pan1p, by the Hip1R-related protein, Sla2p, during endocytosis Academic Article
Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape Academic Article
Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease Academic Article
Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle Academic Article
Networks link antigenic and receptor-binding sites of influenza hemagglutinin: Mechanistic insight into fitter strain propagation Academic Article
NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus Academic Article
Neurexin-neuroligin transsynaptic interaction mediates learning-related synaptic remodeling and long-term facilitation in aplysia Academic Article
Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases Academic Article
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity Academic Article
Neutralizing mutations of carboxylates that bind metal 2 in t5 flap endonuclease result in an enzyme that still requires two metal ions Academic Article
New Arabidopsis cue mutants suggest a close connection between plastid- and phytochrome regulation of nuclear gene expression Academic Article
New addresses on an addressable virus nanoblock: Uniquely reactive lys residues on cowpea mosaic virus Academic Article
New cluster of ribosomal genes in bacillus-subtilis with regulatory role in sporulation Academic Article
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix Academic Article
New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: analysis of the epidermal growth factor-like repeat A docking site using WaterMap Academic Article
Niche partitioning in the coevolution of 2 distinct RNA enzymes Academic Article
Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway Academic Article
Nitrosative and oxidative stress links dysfunctional ubiquitination to Parkinson's disease Academic Article
Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity Academic Article
Non-conventional trafficking of the cystic fibrosis transmembrane conductance regulator through the early secretory pathway Academic Article
Noncanonical NF-kappa B signaling is limited by classical NF-kappa B activity Academic Article
Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity Academic Article
Noncoded amino acid replacement probes of the aspartate aminotransferase mechanism Academic Article
Nonconditional replication-defective mutant of the schmidt-ruppin strain of rous-sarcoma virus Academic Article
Nonconsensus branch-site sequences in the in vitro splicing of transcripts of mutant rabbit beta-globin genes Academic Article
Nonsense mutation in the glycoprotein Ib alpha coding sequence associated with Bernard-Soulier syndrome Academic Article
Not more than 117 base-pairs of 5'-flanking sequence are required for inducible expression of a human ifn-alpha gene Academic Article
Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53 Academic Article
Novel DNA-binding motifs in the DNA-repair enzyme endonuclease-iii crystal-structure Academic Article
Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex Academic Article
Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs) Academic Article
Novel mouse model of autosomal semidominant adult Hypophosphatasia has a splice site mutation in the tissue nonspecific alkaline phosphatase gene Akp2 Academic Article
Novel origin of lpr and gld cells and possible implications in autoimmunity Academic Article
Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis Academic Article
Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases Academic Article
Nuclear lamina at the crossroads of the cytoplasm and nucleus Academic Article
Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein Academic Article
Nuclear-localized BZR1 mediates brassinosteroid-induced growth and feedback suppression of brassinosteroid biosynthesis Academic Article
Nuclear-protein import in permeabilized mammalian-cells requires soluble cytoplasmic factors Academic Article
Nucleotide-free MalK drives the transition of the maltose transporter to the inward-facing conformation Academic Article
Nucleotide-sequence heterogeneity of an rna phage population Academic Article
Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice Academic Article
Observation of covalent intermediates in an enzyme mechanism at atomic resolution Academic Article
Occurrence of CYP1B1 mutations in juvenile open-angle glaucoma with advanced visual field loss Academic Article
Occurrence of partial deletion and substitution of the src gene in the RNA genome of avian sarcoma virus Academic Article
Octopamine receptor OAMB is required for ovulation in Drosophila melanogaster Academic Article
Olfactory learning deficits in mutants for leonardo, a Drosophila gene encoding a 14-3-3 protein Academic Article
On signal sequence polymorphisms and diseases of distribution Academic Article
On the conservation of aminoacyl-transfer ribonucleic acid synthetase genes in bacillus Academic Article
On the stability of parainfluenza virus 5 F proteins Academic Article
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function Academic Article
Oncogene alterations in primary human-colon tumors Academic Article
Oncogenic KRAS confers chemoresistance by upregulating NRF2 Academic Article
Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene Academic Article
Oncogenic pi3k deregulates transcription and translation Academic Article
Oncogenic signaling of class ipi3k isoforms Academic Article
Oncogenic transformation by jun: Role of transactivation and homodimerization Academic Article
Oncogenic transformation induced by membrane-targeted akt2 and akt3 Academic Article
Oncogenic transformation induced by the p110 beta, -gamma, and -delta isoforms of class i phosphoinositide 3-kinase Academic Article
Oncogenicity of avian leukosis viruses of different subgroups and of mutants of sarcoma viruses Academic Article
Oocyte destruction is activated during viral infection Academic Article
Optic nerve axon number in mouse is regulated by PAX2 Academic Article
Optimized clinical performance of growth hormone with an expanded genetic code Academic Article
Optimized heterologous expression of the polymorphic human glutathione transferase M1-1 based on silent mutations in the corresponding cDNA Academic Article
Optimizing the heterologous expression of glutathione transferase Academic Article
Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B Academic Article
Organization of the Rab-GDI/CHM superfamily: The functional basis for choroideremia disease Academic Article
Out of darkness: mutants reveal pathways controlling light-regulated development in plants Academic Article
Outward currents in Drosophila larval neurons: dunce lacks a maintained outward current component downregulated by cAMP Academic Article
Overcoming mutation-based resistance to antiandrogens with rational drug design Academic Article
Overexpression, crystallization and preliminary x-ray crystallographic analysis of the variable lymphocyte receptor 2913 ectodomain fused with internalin b Academic Article
Oxidation inhibits amyloid fibril formation of transthyretin Academic Article
Oxime side-chain cross-links in an α-helical coiled-coil protein: structure, thermodynamics, and folding-templated synthesis of bicyclic species Academic Article
Oxygen sensation and social feeding mediated by a c-elegans guanylate cyclase homologue Academic Article
P38 beta MAP kinase protects rat mesangial cells from TNF-alpha-induced apoptosis Academic Article
P45(skp2) promotes p27(kip1) degradation and induces s phase in quiescent cells Academic Article
PER1 phosphorylation specifies feeding rhythm in mice Academic Article
PKS1, a substrate phosphorylated by phytochrome that modulates light signaling in Arabidopsis Academic Article
PPARG post-translational modifications regulate bone formation and bone resorption Academic Article
PRR3 is a vascular regulator of TOC1 stability in the Arabidopsis circadian clock Academic Article
PSEA-Quant: a protein set enrichment analysis on label-free and label-based protein quantification data Academic Article
PYR/PYL/RCAR family members are major in vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis Academic Article
Palmitoylation-dependent activation of MC1R prevents melanomagenesis Academic Article
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma Academic Article
Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1 Academic Article
Partial characterization and three-dimensional structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria Academic Article
Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis Academic Article
Pas-a domain of phosphorelay sensor kinase a: A catalytic atp-binding domain involved in the initiation of development in bacillus subtilis Academic Article
Pathogenesis of chronic hepatitis C: Immunological features of hepatic injury and viral persistence Academic Article
Pathogenic mutations induce partial structural changes in the native β-sheet structure of transthyretin and accelerate aggregation Academic Article
Patient-derived models of acquired resistance can identify effective drug combinations for cancer Academic Article
Pedigree models for complex human traits involving the mitochondrial genome Academic Article
Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in P22 Academic Article
Pejvakin, a candidate stereociliary rootlet protein, regulates hair cell function in a cell-autonomous manner Academic Article
Penetrance of 845g -> a (c282y) hfe hereditary haemochromatosis mutation in the USA Academic Article
Peroxisome proliferator-activated receptor (ppar) gamma coactivator-1 recruitment regulates ppar subtype specificity Academic Article
Personalized circulating tumor DNA biomarkers dynamically predict treatment response and survival in gynecologic cancers Academic Article
Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer Academic Article
Phage-display evolution of tyrosine kinases with altered nucleotide specificity Academic Article
Pharmacogenomic analysis of mechanisms mediating ethanol regulation of dopamine beta-hydroxylase Academic Article
Pharmacological selectivity within class I histone deacetylases predicts effects on synaptic function and memory rescue Academic Article
Phenotypes of pleiotropic-negative sporulation mutants of bacillus-subtilis Academic Article
Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast Academic Article
Phosphoinositide 3-kinase: From viral oncoprotein to drug target Academic Article
Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases Academic Article
Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory Academic Article
Phosphorylation of the abelson murine leukemia-virus transforming protein Academic Article
Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint Academic Article
Phototransduction and circadian clock pathways regulating gene transcription in higher plants Academic Article
Physiological consequences of defects in ercc1-xpf DNA repair endonuclease Academic Article
Physiological studies of biosynthetic indole excretion in bacillus alvei Academic Article
Physiology and biochemistry of Drosophila learning mutants Academic Article
Phytobilin biosynthesis: the Synechocystis sp PCC 6803 heme oxygenase-encoding ho1 gene complements a phytochrome-deficient Arabidopsis thaliana hy1 mutant Academic Article
Phytochrome A Antagonizes PHYTOCHROME INTERACTING FACTOR 1 to Prevent Over-Activation of Photomorphogenesis Academic Article
Phytochrome B affects responsiveness to gibberellins in Arabidopsis Academic Article
Phytochrome signaling mechanisms and the control of plant development Academic Article
Phytochromes and cryptochromes in the entrainment of the Arabidopsis circadian clock Academic Article
Piezo1 links mechanical forces to red blood cell volume Academic Article
Plasminogen activator inhibitors regulate cell adhesion through a uPAR-dependent mechanism Academic Article
Polymorphism of the mouse tnf-alpha locus - sequence studies of the 3'-untranslated region and 1st intron Academic Article
Polymorphisms a387p in thrombospondin-4 and n700s in thrombospondin-1 perturb calcium binding sites Academic Article
Polymorphisms and mutations of human tmprss6 in iron deficiency anemia Academic Article
Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli Academic Article
Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease Academic Article
Pore region of TRPV3 ion channel is specifically required for heat activation Academic Article
Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response Academic Article
Potential of gene therapy for treating osteogenesis imperfecta Academic Article
Potential of small molecule-mediated reprogramming of rod photoreceptors to treat retinitis pigmentosa Academic Article
Prediction of cancer driver mutations in protein kinases Academic Article
Prediction of quaternary structure of coiled coils. Application to mutants of the GCN4 leucine zipper Academic Article
Preferential recognition of avian-like receptors in human influenza A H7N9 viruses Academic Article
Prevalence of coronary heart disease associated with hfe mutations in adults attending a health appraisal center Academic Article
Prevalence of hemochromatosis-related symptoms among individuals with mutations in the hfe gene Academic Article
Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: Implications for learning and memory Academic Article
Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate Academic Article
Prion protein (prp) with amino-proximal deletions restoring susceptibility of prp knockout mice to scrapie Academic Article
Prion proteins with pathogenic and protective mutations show similar structure and dynamics Academic Article
Prions on the move Academic Article
Prioritizing the development of mouse models for childhood brain disorders Academic Article
Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database Academic Article
Probing domain interactions in soluble guanylate cyclase Academic Article
Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter Academic Article
Probing the mechanism of Staphylococcal nuclease with unnatural amino-acids: kinetic and structural studies Academic Article
Processing of the psbA 5' untranslated region in Chlamydomonas reinhardtii depends upon factors mediating ribosome association Academic Article
Progress in understanding the Drosophila dnc locus Academic Article
Progress toward the evolution of an organism with an expanded genetic code Academic Article
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2 Academic Article
Progressive hearing loss in mice carrying a mutation in Usp53 Academic Article
Properties of mammalian cells transformed by temperature-sensitive mutants of avian sarcoma virus Academic Article
Proportion of revertant and mutant phage in a growing population, as a function of mutation and growth-rate Academic Article
Proposal for numbering mutants of avian leukosis and sarcoma viruses Academic Article
Proprioceptive coupling within motor neurons drives C. elegans forward locomotion Academic Article
Proteasome-Mediated Turnover of Arabidopsis MED25 Is Coupled to the Activation of FLOWERING LOCUS T Transcription Academic Article
Protective immunogenicity of two synthetic peptides selected from the amino acid sequence of Bordetella pertussis toxin subunit S1 Academic Article
Protein DNA contacts in the structure of a homeodomain DNA complex determined by nuclear-magnetic-resonance spectroscopy in solution Academic Article
Protein S-thiolation by Glutathionylspermidine (Gsp): the role of Escherichia coli Gsp synthetASE/amidase in redox regulation Academic Article
Protein c anticoagulant and cytoprotective pathways Academic Article
Protein dynamics studied with ultrafast two-dimensional infrared vibrational echo spectroscopy Academic Article
Protein expression profiles of C3H 10T1/2 murine fibroblasts and of isogenic cells transformed by the H1047R mutant of phosphoinositide 3-kinase (PI3K) Academic Article
Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with escherichia coli uracil-DNA glycosylase Academic Article
Protein phosphatase 2C acts independently of stress-activated kinase cascade to regulate the stress response in fission yeast Academic Article
Protein structure and oligomerization are important for the formation of export-competent HIV-1 Rev-RRE complexes Academic Article
Protein subunit interactions and structural integrity of amyloidogenic transthyretins: Evidence from electrospray mass spectrometry Academic Article
Protein tyrosine phosphatase PTPN13 negatively regulates Her2/ErbB2 malignant signaling Academic Article
Protein-kinase activity associated with the product of the yeast-cell division cycle gene cdc28 Academic Article
Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis Academic Article
Proteomics opens doors to the mechanisms of developmentally regulated secretion Academic Article
Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C Academic Article
Proton release due to manganese binding and oxidation in modified bacterial reaction centers Academic Article
Prp knock-out and prp transgenic mice in prion research Academic Article
Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression Academic Article
Purdue ionomics information management system. An integrated functional genomics platform Academic Article
Pyp3 PTPase acts as a mitotic inducer in fission yeast Academic Article
QQS orphan gene regulates carbon and nitrogen partitioning across species via NF-YC interactions Academic Article
Quantitative mass spectrometry identifies insulin signaling targets in C. elegans Academic Article
Quantitative proteomics and protein network analysis of hippocampal synapses of CaMKII alpha mutant mice Academic Article
Quantitative proteomics of human fibroblasts with I1061T mutation in Niemann-Pick C1 (NPC1) protein provides insights into the disease pathogenesis Academic Article
Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation Academic Article
Quelling the storm: Utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm Academic Article
RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans Academic Article
RCS1, a substrate of APC/C, controls the metaphase to anaphase transition Academic Article
RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1 Academic Article
RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis Academic Article
RNA interference knockdown of BRASSINOSTEROID INSENSITIVE1 in maize reveals novel functions for brassinosteroid signaling in controlling plant architecture Academic Article
RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing Academic Article
RNA recognition by designed peptide fusion creates "artificial" tRNA synthetase Academic Article
RNA-RNA interactions between oligonucleotide substrates for aminoacylation Academic Article
RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization Academic Article
RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint Academic Article
RSF1, an Arabidopsis locus implicated in phytochrome A signaling Academic Article
Rab1 and ca2+ are required for the fusion of carrier vesicles mediating endoplasmic-reticulum to golgi transport Academic Article
Rab1 recruitment of p115 into a cis-SNARE complex: programming budding CPOII vesicles for fusion Academic Article
Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses Academic Article
Rapid accumulation and disappearance of plasma-membrane proteins during development of wild-type and mutant strains of dictyostelium-discoideum Academic Article
Rapid array mapping of circadian clock and developmental mutations in Arabidopsis Academic Article
Rapid deep sequencing of patient-derived HIV with ion semiconductor technology Academic Article
Rapid degradation of the g(1) cyclin cln2 induced by cdk-dependent phosphorylation Academic Article
Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors Academic Article
Rapid selection of genetic and antigenic variants of foot-and-mouth-disease virus during persistence in cattle Academic Article
Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein Academic Article
Rare cancer-specific mutations in pik3ca show gain of function Academic Article
Rationale for engineering an enzyme by introducing a mutation that compensates for a deletion Academic Article
Rationale for the development of 2-aminobenzamide histone deacetylase inhibitors as therapeutics for Friedreich ataxia Academic Article
Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAF(II)250 Academic Article
Reaction dynamics of the UV-B photosensor UVR8 Academic Article
Reaction intermediates in the catalytic mechanism of escherichia coli muty DNA glycosylase Academic Article
Reaction mechanism of single subunit nadh-ubiquinone oxidoreductase (ndi1) from saccharomyces cerevisiae evidence for a ternary complex mechanism Academic Article
Recent avian h5n1 viruses exhibit increased propensity for acquiring human receptor specificity Academic Article
Recent results on how aminoacyl transfer RNA synthetases recognize specific transfer RNAs Academic Article
Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III Academic Article
Recognition of conformational determinants on H-2 by cytolytic T lymphocytes Academic Article
Recognition of rna polymerase ii and transcription bubbles by xpg, csb, and tfiih: Insights for transcription-coupled repair and cockayne syndrome Academic Article
Recognition properties of a panel of human recombinant fab fragments to the cd4 binding-site of gp120 that show differing abilities to neutralize human-immunodeficiency-virus type-1 Academic Article
Recommendations for the nomenclature of mutant fibrinolytic genes and their proteins. Report of the SSC Fibrinolysis Subcommittee 1990 Academic Article
Recruitment of a 19s proteasome subcomplex to an activated promoter Academic Article
Redesigning recombinase specificity for safe harbor sites in the human genome Academic Article
Redox-based reagents for chemoselective methionine bioconjugation Academic Article
Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: Evidence for a link between defects in the endocannabinoid system and problem drug use Academic Article
Reduced cholesterol and triglycerides in mice with a mutation in mia2, a liver protein that localizes to er exit sites Academic Article
Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of schizophrenia Academic Article
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis Academic Article
Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants Academic Article
Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice Academic Article
Reelin, disabled 1, and beta(1) integrins are required for the formation of the radial glial scaffold in the hippocampus Academic Article
Reference centiles for serum ferritin and percentage of transferrin saturation, with application to mutations of the hfe gene Academic Article
Refined crystallographic structure of pseudomonas aeruginosa exotoxin a and its implications for the molecular mechanism of toxicity Academic Article
Regio- and enantioselectivities in epoxide conjugations are modulated by residue 210 in Mu class glutathione transferases Academic Article
Regulation and recognition of scfgrr1 targets in the glucose and amino acid signaling pathways Academic Article
Regulation of Alkyl-dihydrothiazole-carboxylates (ATCs) by Iron and the Pyochelin Gene Cluster in Pseudomonas aeruginosa Academic Article
Regulation of NT-PGC-1 alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1 Academic Article
Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein Academic Article
Regulation of Sufu activity by p66 beta and Mycbp provides new insight into vertebrate Hedgehog signaling Academic Article
Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development Academic Article
Regulation of flowering time by light quality Academic Article
Regulation of flowering time in Arabidopsis by K homology domain proteins Academic Article
Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin Academic Article
Regulation of lactate-dehydrogenase synthesis in bacillus-subtilis Academic Article
Regulation of membrane trafficking and organ separation by the NEVERSHED ARF-GAP protein Academic Article
Regulation of receptor fate by ubiquitination of activated beta(2)-adrenergic receptor and beta-arrestin Academic Article
Regulation of receptor-mediated endocytosis by rho and rac Academic Article
Regulation of retinoblastoma protein functions by ectopic expression of human cyclins Academic Article
Regulation of the cycling of timeless (tim) RNA Academic Article
Regulation of the oxidative stress response by the hpr gene in bacillus-subtilis Academic Article
Relative abundance of alzheimer a-beta amyloid peptide variants in alzheimer-disease and normal aging Academic Article
Release factor one is nonessential in Escherichia coli Academic Article
Replication checkpoint kinase Cds1 regulates Mus81 to reserve genome integrity during replication stress Academic Article
Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60 Academic Article
Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast Academic Article
Replication of a hepatitis C virus replicon clone in mouse cells Academic Article
Replication-independent histone deposition by the HIR complex and Asf1 Academic Article
Repression of the IgH enhancer in teratocarcinoma cells associated with a novel octamer factor Academic Article
Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control Academic Article
Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development Academic Article
Requirement of cks2 for the first metaphase/anaphase transition of mammalian meiosis Academic Article
Reshaping antibody diversity Academic Article
Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1 Academic Article
Residue met(156) contributes to the labile enzyme conformation of coagulation factor viia Academic Article
Resistance to activated protein C: A common inherited cause of venous thrombosis Academic Article
Response of patients with phenylketonuria in the us to tetrahydrobiopterin Academic Article
Restitution of fibroblast-transforming ability in src deletion mutants of avian-sarcoma virus during animal passage Academic Article
Restriction fragment analysis confirms the position-33 mutation in transthyretin from an israeli patient (SKO) with familial amyloidotic polyneuropathy Academic Article
Retinoid x receptor is a nonsilent major contributor to vitamin d receptor-mediated transcriptional activation Academic Article
Reversion from transformed to normal phenotype by inhibition of protein synthesis in rat kidney cells infected with a temperature-sensitive mutant of Rous sarcoma virus Academic Article
Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency Academic Article
Review and Hypothesis. New insights into the reaction mechanism of transhydrogenase: Swivelling the dIII component may gate the proton channel Academic Article
Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9 Academic Article
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia Academic Article
Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo Academic Article
Rho kinase inhibition as a therapeutic for progressive supranuclear palsy and corticobasal degeneration Academic Article
Ribosomal protein S1 binds mRNA and tmRNA similarly but plays distinct roles in translation of these molecules Academic Article
Ribosomal route to small-molecule diversity Academic Article
Ricin cytotoxicity is sensitive to recycling between the endoplasmic-reticulum and the Golgi-complex Academic Article
Ring finger Z protein of lymphocytic choriomeningitis virus (LCMV) inhibits transcription and RNA replication of an LCMV-S-segment minigenome Academic Article
Role for the rho-family gtpase cdc42 in yeast mating-pheromone signal pathway Academic Article
Role of Doa1 in the Saccharomyces cerevisiae DNA damage response Academic Article
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome Academic Article
Role of an active site adenine in hairpin ribozyme catalysis Academic Article
Role of hydrogen bonding in the active site of human manganese superoxide dismutase Academic Article
Role of matriptase-2 (tmprss6) in iron metabolism Academic Article
Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina Academic Article
Role of the PROS1 gene in thrombosis: lessons and controversies Academic Article
Role of the clock protein in the mammalian circadian mechanism Academic Article
Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by reelin signaling mutant mice Academic Article
Role of zymogen and activated factor x as scaffolds for the inhibition of the blood coagulation factor viia-tissue factor complex by recombinant nematode anticoagulant protein c2 Academic Article
Roles of Wee1 and Nim1 protein kinases in regulating the switch from mitotic division to sexual development in Schizosaccharomyces pombe Academic Article
Roles of the mitotic inhibitors Wee1 and Mik1 in the G(2) DNA damage and replication checkpoints Academic Article
Root suberin forms an extracellular barrier that affects water relations and mineral nutrition in Arabidopsis Academic Article
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury Academic Article
S1p(1)-selective in vivo-active agonists from high-throughput screening: Off-the-shelf chemical probes of receptor interactions, signaling, and fate Academic Article
SIR1, an upstream component in auxin signaling identified by chemical genetics Academic Article
SLEEPLESS-ness and insomnia in fruit flies Academic Article
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis Academic Article
STIMPY mediates cytokinin signaling during shoot meristem establishment in Arabidopsis seedlings Academic Article
SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements Academic Article
SV40 T antigen interacts with Nbs1 to disrupt DNA replication control Academic Article
SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS Academic Article
Saccharomyces cerevisiae as a model system to define the chromosomal instability phenotype Academic Article
Schizosaccharomyces pombe and Saccharomyces cerevisiae: a look at yeasts divided Academic Article
Screening strategies in C282Y-linked haemochromatosis Academic Article
Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity Academic Article
Seeking candidate mutations that affect iron homeostasis Academic Article
Selected mutants of mouse hepatitis-virus type-4 (jhm-strain) induce different cns diseases - pathobiology of disease induced by wild-type and mutant-ts8 and mutant-ts15 in balb/c and sjl/j mice Academic Article
Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA Academic Article
Selection of cells transformed to prototrophy for sporulation markers Academic Article
Selective decrease in paracellular conductance of tight junctions: role of the first extracellular domain of claudin-5 Academic Article
Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk Academic Article
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells Academic Article
Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, lPB3/EDG-3 Academic Article
Selective modification of variable loops alters tropism and enhances immunogenicity of human immunodeficiency virus type 1 envelope Academic Article
Selective vulnerability of dentate granule cells prior to amyloid deposition in pdapp mice: Digital morphometric analyses Academic Article
Semiquinone and cluster N6 signals in His-tagged proton-translocating NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli Academic Article
Sequence and structural convergence of broad and potent hiv antibodies that mimic cd4 binding Academic Article
Sequence and structure signatures of cancer mutation hotspots in protein kinases Academic Article
Sequence determinants of a protein folding pathway Academic Article
Sequence determinants of thermodynamic stability in a ww domain. An all-beta-sheet protein Academic Article
Sequence interpretation. Functional annotation of mouse genome sequences Academic Article
Sequence requirements for splicing of higher eukaryotic nuclear pre-messenger-rna Academic Article
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas Academic Article
Sequence-analysis of temperature-sensitive mutations in the saccharomyces-cerevisiae gene cdc28 Academic Article
Sequence-analysis of the spo0b locus reveals a polycistronic transcription unit Academic Article
Sequence-specific h-1, c-13 and n-15 assignment of the tmp-resistant dihydrofolate reductase mutant dhfr(f98y) in the ternary complex with tmp and nadph Academic Article
Sequential mutations in hemagglutinins of influenza-b virus isolates - definition of antigenic domains Academic Article
Sequential phases of cortical specification involve neurogenin-dependent and -independent pathways Academic Article
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations Academic Article
Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression Academic Article
Serine and lipid metabolism in macular disease and peripheral neuropathy Academic Article
Serum leptin and body composition in children with familial GH deficiency (GHD) due to a mutation in the growth hormone-releasing hormone (GHRH) receptor Academic Article
Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency Academic Article
Severe iron overload with a novel aminolevulinate synthase mutation and hepatitis c infection. A case report Academic Article
Sexual cell-fate reprogramming in the ovary by DMRT1 Academic Article
Shade avoidance 4 is required for proper auxin distribution in the hypocotyl Academic Article
Shade avoidance 6 encodes an Arabidopsis flap endonuclease required for maintenance of genome integrity and development Academic Article
Shape-specific nucleotide binding of single-stranded RNA by the GLD-1 STAR domain Academic Article
Shigella applies molecular mimicry to subvert vinculin and invade host cells Academic Article
Sigma-1 receptor knockout mice display a depressive-like phenotype Academic Article
Signal transduction between the chloroplast and the nucleus Academic Article
Signal-transduction pathways controlling light-regulated development in Arabidopsis Academic Article
Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells Academic Article
Signals involved in Arabidopsis resistance to Trichoplusia ni caterpillars induced by virulent and avirulent strains of the phytopathogen Pseudomonas syringae Academic Article
Significance of the amyloidogenic transthyretin Val 122 Ile allele in African Americans in the arteriosclerosis risk in communities (ARIC) and cardiovascular health (CHS) studies Academic Article
Significant structural and functional change of an antigen-binding site by a distant amino-acid substitution - proposal of a structural mechanism Academic Article
Single amino-acid changes that render human ifn-alpha-2 biologically-active on mouse cells Academic Article
Single chemical modifications of the c-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks Academic Article
Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase Academic Article
Single ribosomal protein mutations in antibiotic-resistant bacteria analyzed by mass spectrometry Academic Article
Site-directed mutagenesis in DNA: generation of point mutations in cloned β globin complementary DNA at the positions corresponding to amino acids 121 to 123 Academic Article
Site-directed mutagenesis of azotobacter-vinelandii ferredoxin-i - fe-s cluster-driven protein rearrangement Academic Article
Site-directed mutagenesis: effect of an extracistronic mutation on the in vitro propagation of bacteriophage Qbeta RNA Academic Article
Site-directed mutagenesis: generation of an extracistronic mutation in bacteriophage Qβ RNA Academic Article
Site-directed spin labeling of a genetically encoded unnatural amino acid Academic Article
Site-specific incorporation of ε-N-crotonyllysine into histones Academic Article
Site-specific mutagenesis with unnatural amino acids Academic Article
Site-specific recombination of asymmetric lox sites mediated by a heterotetrameric Cre recombinase complex Academic Article
Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells Academic Article
Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of Smoothened Academic Article
Small molecules affecting transcription in Friedreich ataxia Academic Article
Sodium ion binding pocket mutations and adenosine A2A receptor function Academic Article
Solution NMR spectroscopy of alpha-n-15 lysine-labeled rhodopsin: The single peak observed in both conventional and trosy-type hsqc spectra is ascribed to lys-339 in the carboxyl-terminal peptide sequence Academic Article
Solution structure of the third immunoglobulin domain of the neural cell adhesion molecule N-CAM: can solution studies define the mechanism of homophilic binding? Academic Article
Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation Academic Article
Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas Academic Article
Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis Academic Article
Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid Academic Article
Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity Academic Article
Specific H chain junctional diversity may be required for non-T15 antibodies to bind phosphorylcholine Academic Article
Specific inhibition of HBV replication in vitro and in vivo with expressed long hairpin RNA Academic Article
Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival Academic Article
Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana Academic Article
Spiroindolones, a potent compound class for the treatment of malaria Academic Article
Spo0a activates and represses its own synthesis by binding at its dual promoters Academic Article
Stability and conformation of a chemoreceptor HAMP domain chimera correlates with signaling properties Academic Article
Stability of hairpin ribozyme tertiary structure is governed by the interdomain junction Academic Article
Stabilizing and destabilizing effects of placing beta-branched amino-acids in protein alpha-helices Academic Article
Statistical coupling analysis-guided library design for the discovery of mutant luciferases Academic Article
Stealth and cunning: hepatitis B and hepatitis C viruses Academic Article
Stimulation of nuclear export and inhibition of nuclear import by a ran mutant deficient in binding to ran-binding protein 1 Academic Article
Stn1, a new saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with cdc13 Academic Article
Streptococcus mutans protein synthesis during mixed-species biofilm development by high-throughput quantitative proteomics Academic Article
Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin alpha 2/beta 1 heterodimer Academic Article
Structural alterations in the bacillus-subtilis spooa regulatory protein which suppress mutations at several spoo loci Academic Article
Structural and biophysical insights into the ligand-free Pitx2 homeodomain and a ring dermoid of the cornea inducing homeodomain mutant Academic Article
Structural and chemical requirements for histidine phosphorylation by the chemotaxis kinase CheA Academic Article
Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex Academic Article
Structural and functional analysis of mre11-3 Academic Article
Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19 Academic Article
Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1 Academic Article
Structural and functional analysis of the plasminogen activator inhibitor-1 binding motif in the somatomedin B domain of vitronectin Academic Article
Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding Academic Article
Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes Academic Article
Structural and functional identification of major histocompatibility complex class i-restricted self-peptides as naturally occurring molecular mimics of viral antigens - possible role in cd8(+) t cell-mediated, virus-induced autoimmune disease Academic Article
Structural basis for a switch in receptor binding specificity of two H5N1 hemagglutinin mutants Academic Article
Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway Academic Article
Structural basis for type-I and type-II deficiencies of antithrombotic plasma protein-C - patterns revealed by 3-dimensional molecular modeling of mutations of the protease domain Academic Article
Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12 Academic Article
Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain Academic Article
Structural basis of autoregulation of phenylalanine hydroxylase Academic Article
Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion Academic Article
Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen Academic Article
Structural changes associated with transthyretin misfolding and amyloid formation revealed by solution and solid-state NMR Academic Article
Structural changes that occur upon photolysis of the fe(ii)(a3)-co complex in the cytochrome ba(3)-oxidase of thermus thermophilus: A combined x-ray crystallographic and infrared spectral study demonstrates co binding to cu-b Academic Article
Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS Academic Article
Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: Similar fold, different stability and reaction rates Academic Article
Structural determinants of cys2his2 zinc fingers Academic Article
Structural evidence for substrate strain in antibody catalysis Academic Article
Structural insight into pH-induced conformational changes within the native human transthyretin tetramer Academic Article
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor Academic Article
Structural insights into conformational flexibility at the peripheral site and within the active center gorge of ache Academic Article
Structural insights into neonatal Fc receptor-based recycling mechanisms Academic Article
Structural insights into the evolution of an antibody combining site Academic Article
Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins Academic Article
Structural mechanism associated with domain opening in gain-of-function mutations in SHP2 phosphatase Academic Article
Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach Academic Article
Structural plasticity and the evolution of antibody affinity and specificity Academic Article
Structurally novel antiestrogens elicit differential responses from constitutively active mutant estrogen receptors in breast cancer cells and tumors Academic Article
Structure and activity of a thermostable thymine-DNA glycosylase: Evidence for base twisting to remove mismatched normal DNA bases Academic Article
Structure and dynamics of RNA repeat expansions that cause Huntington's disease and myotonic dystrophy type 1 Academic Article
Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly Academic Article
Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor Academic Article
Structure and function of an unusual family of protein phosphatases: the bacterial chemotaxis proteins CheC and CheX Academic Article
Structure and function of phage rna Academic Article
Structure and function of the von Willebrand factor A1 domain Academic Article
Structure and mechanism of the ruvb holliday junction branch migration motor Academic Article
Structure and molecular organization of mammalian fatty acid synthase Academic Article
Structure and receptor specificity of the hemagglutinin from an h5n1 influenza virus Academic Article
Structure determination of the antp(c39- s) homeodomain from nuclear-magnetic-resonance data in solution using a novel strategy for the structure calculation with the programs diana, caliba, habas and glomsa Academic Article
Structure of Dicer and mechanistic implications for RNAi Academic Article
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Academic Article
Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase Academic Article
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator Academic Article
Structure of an essential type iv pilus biogenesis protein provides insights into pilus and type ii secretion systems Academic Article
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone Academic Article
Structure of the I-1 early intermediate of photoactive yellow protein by FTIR spectroscopy Academic Article
Structure of the gene for the transition-state regulator, abrb - regulator synthesis is controlled by the spooa sporulation gene in bacillus-subtilis Academic Article
Structure of the heterodimeric complex between CAD domains of CAD and ICAD Academic Article
Structure of the human ATG12 similar to ATG5 conjugate required for LC3 lipidation in autophagy Academic Article
Structure of the inhibitory region of troponin by site directed spin labeling electron paramagnetic resonance Academic Article
Structure of the n terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members Academic Article
Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of Mycobacteria Academic Article
Structure, dynamics, and catalytic function of dihydrofolate reductase Academic Article
Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B Academic Article
Structure-activity relationships in a peptidic alpha 7 nicotinic acetylcholine receptor antagonist Academic Article
Structure-activity relationships in the binding of chemically derivatized cd4 to gp120 from human immunodeficiency virus Academic Article
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells Academic Article
Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death Academic Article
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457 Academic Article
Structures of thermolabile mutants of human glutathione transferase P1-1 Academic Article
Studies on control of development - isolation of bacillus-subtilis mutants blocked early in sporulation and defective in synthesis of highly phosphorylated nucleotides Academic Article
Substituting c-jun n-terminal kinase-3 (jnk3) atp-binding site amino acid residues with their p38 counterparts affects binding of jnk- and p38-selective inhibitors Academic Article
Subunit-destabilizing mutations in drosophila copper-zinc superoxide-dismutase - neuropathology and a model of dimer dysequilibrium Academic Article
Superoxide dismutase from the eukaryotic thermophile alvinella pompejana: Structures, stability, mechanism, and insights into amyotrophic lateral sclerosis Academic Article
Suppression of host p53 is critical for Plasmodium liver-stage infection Academic Article
Suppression of phospholipase Dγs confers increased aluminum resistance in Arabidopsis thaliana Academic Article
Surface-plasmon resonance based kinetic-studies of zinc-finger DNA interactions Academic Article
Sustained NIK-mediated antiviral signalling confers broad-spectrum tolerance to begomoviruses in cultivated plants Academic Article
Symmetrical stabilization of bound Ca2+ ions in a cooperative pair of EF-hands through hydrogen bonding of coordinating water molecules in calbindin D-9k Academic Article
SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons Academic Article
Synapses form in skeletal muscles lacking neuregulin receptors Academic Article
Synthesis of selective agonists for the alpha 7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates Academic Article
Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition Academic Article
Synthetic peptide model of an essential region of an aminoacyl-tRNA synthetase Academic Article
Systematic comparison of respiratory syncytial virus-induced memory B cell responses in two anatomical compartments Academic Article
Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2 Academic Article
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses Academic Article
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow Academic Article
T-cell receptor beta-chain binding to enterotoxin superantigens Academic Article
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium Academic Article
Tak1, but not tab1 or tab2, plays an essential role in multiple signaling pathways in vivo Academic Article
Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response Academic Article
Targeted gene correction of laminopathy-associated lmna mutations in patient-specific ipscs Academic Article
Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer Academic Article
Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies Academic Article
Targeting renal cell carcinoma with a HIF-2 antagonist Academic Article
Targeting the arginine phosphatase YwlE with a catalytic redox-based inhibitor Academic Article
Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening Academic Article
Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B Academic Article
Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein Academic Article
Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres Academic Article
Temperature sensitive mutants of an avian sarcoma virus Academic Article
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain Academic Article
Temperature-sensitive changes in surface modulating assemblies of fibroblasts transformed by mutants of rous-sarcoma virus Academic Article
Temperature-sensitive lethal pseudorevertants of ste mutations in saccharomyces-cerevisiae Academic Article
Temperature-sensitive mutants of avian-sarcoma viruses - genetic recombination with wild-type sarcoma-virus and physiological analysis of multiple mutants Academic Article
Temperature-sensitive mutants of avian-sarcoma viruses - genetic-recombination between multiple or coordinate mutants and avian-leukosis viruses Academic Article
Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination Academic Article
Temperature-sensitive v-sea transformed erythroblasts: A model system to study gene expression during erythroid differentiation Academic Article
Temporal requirement for SMN in motoneuron development Academic Article
Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment Academic Article
Tetrameric architecture of the circadian clock protein KaiB - a novel interface for intermolecular interactions and its impact on the circadian rhythm Academic Article
The Arabidopsis DESPERADO/AtWBC11 transporter is required for cutin and wax secretion Academic Article
The Arabidopsis PEX12 gene is required for peroxisome biogenesis and is essential for development Academic Article
The Arabidopsis SRR1 gene mediates phyB signaling and is required for normal circadian clock function Academic Article
The Arabidopsis deetiolated2 mutant is blocked early in Brassinosteroid biosynthesis Academic Article
The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis Academic Article
The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation Academic Article
The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres Academic Article
The CREB family of activators is required for endochondral bone development Academic Article
The Drosophila TRPP cation channel, PKD2 and Dmel/Ced-12 act in genetically distinct pathways during apoptotic cell clearance Academic Article
The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily Academic Article
The E-2.65 A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors Academic Article
The EF-hand domain: a globally cooperative structural unit Academic Article
The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth Academic Article
The FEAR protein Slk19 restricts Cdc14 phosphatase to the nucleus until the end of anaphase, regulating its participation in mitotic exit in Saccharomyces cerevisiae Academic Article
The K+ channel gene ether a go-go is required for the transduction of a subset of odorants in adult Drosophila melanogaster Academic Article
The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice Academic Article
The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe Academic Article
The NS5A protein of hepatitis C virus is a zinc metalloprotein Academic Article
The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and beta-catenin Academic Article
The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex Academic Article
The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins Academic Article
The RNA binding protein CPEB regulates dendrite morphogenesis and neuronal circuit assembly in vivo Academic Article
The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast Academic Article
The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage Academic Article
The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II Academic Article
The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects Academic Article
The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast Academic Article
The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways Academic Article
The ability of E1A to rescue ras-induced premature senescence and confer transformation relies on inactivation of both p300/CBP and Rb family proteins Academic Article
The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine Academic Article
The active-site residue Tyr-175 in human glyoxalase II contributes to binding of glutathione derivatives Academic Article
The akt kinase: Molecular determinants of oncogenicity Academic Article
The anaerobic degradation of aromatic compounds by a denitrifying bacterium. Radioisotope and mutant studies Academic Article
The anticoagulant function of coagulation factor v Academic Article
The bacillus subtilis genes for ribonucleotide reductase are similar to the genes for the second class i nrde/nrdf enzymes of enterobacteriaceae Academic Article
The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12 Academic Article
The carboxy terminus of the viral jun oncoprotein is required for complex-formation with the cellular fos protein Academic Article
The catalytic site of cytochrome P4504A11 (CYP4A11) and its L131F mutant Academic Article
The catalytic subunit of phosphoinositide 3-kinase: Requirements for oncogenicity Academic Article
The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium Academic Article
The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins Academic Article
The cbpa gene - role of the 26,000-dalton carbohydrate-binding protein in inter-cellular cohesion of developing dictyostelium-discoideum cells Academic Article
The chemistry of the antibody molecule Academic Article
The clinical continuum of cryopyrinopathies - Novel CIAS1 mutations in north American patients and a new cryopyrin model Academic Article
The co-ordination of nuclear and organellar genome expression in eukaryotic cells Academic Article
The complete genome sequences, unique mutational spectra, and developmental potency of adult neurons revealed by cloning Academic Article
The consensus sequence ygtgttyy located downstream from the aataaa signal is required for efficient formation of messenger-rna 3' termini Academic Article
The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability Academic Article
The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase Academic Article
The critical role of membralin in postnatal motor neuron survival and disease Academic Article
The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity Academic Article
The cyclic AMP phosphodiesterase encoded by the Drosophila dunce gene is concentrated in the mushroom body neuropil Academic Article
The cytochrome ba(3) oxygen reductase from thermus thermophilus uses a single input channel for proton delivery to the active site and for proton pumping Academic Article
The dachshund gene is required for the proper guidance and branching of mushroom body axons in Drosophila melanogaster Academic Article
The designability of protein switches by chemical rescue of structure: mechanisms of inactivation and reactivation Academic Article
The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase Academic Article
The deubiquitinating enzyme AMSH3 is required for intracellular trafficking and vacuole biogenesis in Arabidopsis thaliana Academic Article
The dissection and engineering of sites that affect the activity of an enzyme of unknown structure Academic Article
The effect of supercoiling on the in vitro transcription of the spoIIA operon from Bacillus subtilis Academic Article
The effects of ionic strength on protein stability: the cold shock protein family Academic Article
The end-joining reaction in V(D)J recombination Academic Article
The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism Academic Article
The enterococcus faecalis fsr two-component system controls biofilm development through production of gelatinase Academic Article
The epidermis both drives and restricts plant shoot growth Academic Article
The ermC leader peptide: amino acid alterations leading to differential efficiency of induction by macrolide-lincosamide-streptogramin B antibiotics Academic Article
The evolutionarily conserved residue A653 plays a key role in HERG channel closing Academic Article
The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis Academic Article
The fibrillin-1 gene: Unlocking new therapeutic pathways in cardiovascular disease Academic Article
The folding mechanism of a beta-sheet: the WW domain Academic Article
The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity Academic Article
The genes for myelin revisited Academic Article
The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb Academic Article
The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation Academic Article
The hydrophobic patch of ubiquitin is required to protect transactivator-promoter complexes from destabilization by the proteasomal atpases Academic Article
The immunological evolution of catalysis Academic Article
The influence of adenovirus fiber structure and function on vector development for gene therapy Academic Article
The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1 Academic Article
The integrity of the cysteine-186-cysteine-209 bond of the 2nd disulfide loop of tissue factor is required for binding of factor-vii Academic Article
The internal ribosome entry site (ires) contained within the rna-binding motif protein 3 (rbm3) mrna is composed of functionally distinct elements Academic Article
The interplay between binding energy and catalysis in the evolution of a catalytic antibody Academic Article
The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain Academic Article
The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes Academic Article
The long-term memory trace formed in the Drosophila α/β mushroom body neurons is abolished in long-term memory mutants Academic Article
The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1 Academic Article
The maltose ABC transporter: Action of membrane lipids on the transporter stability, coupling and ATPase activity Academic Article
The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos Academic Article
The membrane subunit nuol(nd5) is involved in the indirect proton pumping mechanism of escherichia coli complex i Academic Article
The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis Academic Article
The molecular chaperone Hsp90α is required for meiotic progression of spermatocytes beyond pachytene in the mouse Academic Article
The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway Academic Article
The novel ets factor tel2 cooperates with myc in b lymphomagenesis Academic Article
The oligopeptide transport-system of bacillus-subtilis plays a role in the initiation of sporulation Academic Article
The oncogenicity of jun Academic Article
The organization of endoplasmic reticulum export complexes Academic Article
The pathogenesis of transthyretin tissue deposition: Lessons from transgenic mice Academic Article
The pds1 anaphase inhibitor and mec1 kinase define distinct checkpoints coupling s phase with mitosis in budding yeast Academic Article
The phenotype of Arabidopsis thaliana det1 mutants suggests a role for cytokinins in greening Academic Article
The phosphoenolpyruvate/phosphate translocator is required for phenolic metabolism, palisade cell development, and plastid-dependent nuclear gene expression Academic Article
The polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo Academic Article
The product of the natural reaction catalyzed by 4-oxalocrotonate tautomerase becomes an affinity label of its mutant Academic Article
The proper connection between shelterin components is required for telomeric heterochromatin assembly Academic Article
The protease activity of yeast separase (esp1) is required for anaphase spindle elongation independently of its role in cleavage of cohesin Academic Article
The protein kinase cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast Academic Article
The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance: a review Academic Article
The rad50 signature motif: Essential to atp binding and biological function Academic Article
The rad50 zinc-hook is a structure joining mre11 complexes in DNA recombination and repair Academic Article
The receptor-binding and membrane-fusion properties of influenza-virus variants selected using anti-hemagglutinin monoclonal-antibodies Academic Article
The red thread: oncogenes and their convergence in cancer research Academic Article
The regulation of retina specific expression of rhodopsin gene in vertebrates Academic Article
The retinoblastoma susceptibility gene-product regulates Myc-mediated transcription Academic Article
The role of ARF1 and rab GTPases in polarization of the Golgi stack Academic Article
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins Academic Article
The role of Drosophila mushroom body signaling in olfactory memory Academic Article
The role of cytochrome-P-450 forms in 2-aminoanthracene and benz alpha pyrene mutagenesis Academic Article
The role of prp in health and disease Academic Article
The role of retroviral dutpases in replication and virulence Academic Article
The roles of S1 RNA-binding domains in Rrp5's interactions with pre-rRNA Academic Article
The search for Lps: 1993-1998 Academic Article
The selection of amber mutations in genes required for completion of start, the controlling event of the cell-division cycle of s-cerevisiae Academic Article
The selection of s-cerevisiae mutants defective in the start event of cell-division Academic Article
The self-inhibited structure of full-length PCSK9 at 1.9 Å reveals structural homology with resistin within the C-terminal domain Academic Article
The serine protease tmprss6 is required to sense iron deficiency Academic Article
The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle Academic Article
The short-period mutant, toc1-1, alters circadian clock regulation of multiple outputs throughout development in Arabidopsis thaliana Academic Article
The signal sequence of lymphocytic choriomeningitis virus contains an immunodominant cytotoxic t cell epitope that is restricted by both h-2d(b) and h-2k(b) molecules Academic Article
The size-wise nucleus: nuclear volume control in eukaryotes Academic Article
The structural basis of phenylketonuria Academic Article
The structural basis of recognition and removal of cellular mrna 7-methyl g 'caps' by a viral capsid protein: A unique viral response to host defense Academic Article
The structure of apo human glutamate dehydrogenase details subunit communication and allostery Academic Article
The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0 Å resolution Academic Article
The structure of pariacoto virus reveals a dodecahedral cage of duplex rna Academic Article
The structure of the yeast nadh dehydrogenase (ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates Academic Article
The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERR alpha) Academic Article
The transition-state transcription regulator abrb of bacillus-subtilis is autoregulated during vegetative growth Academic Article
The tropomodulin (Tmod) gene maps to chromosome 4, closely linked to Mup1 Academic Article
The ydaO motif is an ATP-sensing riboswitch in Bacillus subtilis Academic Article
Therapeutic strategies to ameliorate lysosomal storage disorders - a focus on Gaucher disease Academic Article
Three-dimensional structure of a recombinant gap junction membrane channel Academic Article
Thrombosis in otherwise well children with the factor V leiden mutation Academic Article
Thrombospondin-4 and its variants - expression and differential effects on endothelial cells Academic Article
TiMEx: a waiting time model for mutually exclusive cancer alterations Academic Article
Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor 1(2)tid, is critical for early embryonic development and cell survival Academic Article
Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands Academic Article
Tissue factor residue asp(44) regulates catalytic function of the bound proteinase factor vlla Academic Article
Tissue factor residues lys(165) and lys(166) are essential for rapid formation of the quaternary complex of tissue-factor-center-dot-viia with xa-center-dot-tissue factor pathway inhibitor Academic Article
Tissue-specific expressed antibody variable gene repertoires Academic Article
Toll-like receptors: How they work and what they do Academic Article
Tomato BRASSINOSTEROID INSENSITIVE1 is required for systemin-induced root elongation in Solanum pimpinellifolium but is not essential for wound signaling Academic Article
Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance Academic Article
Topoisomerase II suppresses the temperature sensitivity of Saccharomyces cerevisiae pds5 mutants, but not the defect in sister chromatid cohesion Academic Article
TorsinA and torsion dystonia: unraveling the architecture of the nuclear envelope Academic Article
Towards a comprehensive structural variation map of an individual human genome Academic Article
Traffic pattern of cystic fibrosis transmembrane regulator through the early exocytic pathway Academic Article
Trans-complementation rescue of cyclophilin A-deficient viruses reveals that the requirement for cyclophilin A in human immunodeficiency virus type 1 replication is independent of its isomerase activity Academic Article
Trans-suppression of misfolding in an amyloid disease Academic Article
Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus Academic Article
Transcription factor HAT1 is phosphorylated by BIN2 kinase and mediates brassinosteroid repressed gene expression in Arabidopsis Academic Article
Transcription of bacillus-subtilis subtilisin and expression of subtilisin in sporulation mutants Academic Article
Transcriptional analysis of the caulobacter 4.5 s rna ffs gene and the physiological basis of an ffs mutant with a ts phenotype Academic Article
Transcriptional and proteomic analysis of a ferric uptake regulator (fur) mutant of Shewanella oneidensis: possible involvement of fur in energy metabolism, transcriptional regulation, and oxidative stress Academic Article
Transcriptional code and disease map for adult retinal cell types Academic Article
Transfer of a prion strain to different hosts leads to emergence of strain variants Academic Article
Transferrin-mediated targeting of bacteriophage hk97 nanoparticles into tumor cells Academic Article
Transformation and insertional mutagenesis in vitro of primary hematopoietic stem cell cultures Academic Article
Transgenerational epigenetic instability is a source of novel methylation variants Academic Article
Translation of the chloroplast psbA mRNA requires the nuclear-encoded poly(A)-binding protein, RB47 Academic Article
Translational attenuation differentially alters the fate of disease-associated fibulin proteins Academic Article
Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models Academic Article
Transport and secretion of truncated t-cell receptor beta-chain occurs in the absence of association with cd3 Academic Article
Transthyretin Pro-36 associated with familial amyloidotic polyneuropathy in an Ashkenazic Jewish kindred Academic Article
Transthyretin Pro55, a variant associated with early-onset, aggressive, diffuse amyloidosis with cardiac and neurologic involvement Academic Article
Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity Academic Article
Trif is not required for immune complex glomerulonephritis: Dying cells activate mesangial cells via tlr2/myd88 rather than tlr3/trif Academic Article
Triple aminoacylation specificity of a chimerized transfer RNA Academic Article
Trp-dependent auxin biosynthesis in Arabidopsis: involvement of cytochrome P450s CYP79B2 and CYP79B3 Academic Article
Ts transformation mutants of avian-sarcoma virus-prcii - lack of strict correlation between transforming ability and properties of the p105-associated kinase Academic Article
Ts-pol mutants of avian-sarcoma viruses - mapping and demonstration of single cycle recombinants Academic Article
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition Academic Article
Tumor regression by targeted gene delivery to the neovasculature Academic Article
Tuning assembly size in peptide-based supramolecular polymers by modulation of subunit association affinity Academic Article
Turning a protein kinase on or off from a single allosteric site via disulfide trapping Academic Article
Two modes of protein sequence evolution and their compositional dependencies Academic Article
Two murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genes Academic Article
Two mutations in the dispensable part of alanine tRNA synthetase which affect the catalytic activity Academic Article
Two novel SOD1 mutations in patients with familial amyotrophic lateral sclerosis Academic Article
Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects Academic Article
Two small c-type cytochromes affect virulence gene expression in bacillus anthracis Academic Article
Two structural scenarios for protein stabilization by PEG Academic Article
Two-dimensional IR spectroscopy of protein dynamics using two vibrational labels: a site-specific genetically encoded unnatural amino acid and an active site ligand Academic Article
Type 5 G protein beta subunit (G beta 5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors Academic Article
Type B response regulators act as central integrators in transcriptional control of the auxin biosynthesis enzyme TAA1 Academic Article
Tyrosine and serine phosphorylation regulate the conformation and subsequent threonine phosphorylation of the L1 cytoplasmic domain Academic Article
Tyrosine cross-linking reveals interfacial dynamics in adeno-associated viral capsids during infection Academic Article
Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase inhibitor Academic Article
UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin Academic Article
Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling Academic Article
Ubiquitin facilitates a quality-control pathway that removes damaged chloroplasts Academic Article
Ubiquitin ligase activity of tfiih and the transcriptional response to DNA damage Academic Article
Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production Academic Article
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates Academic Article
Ubiquitylation of cyclin e requires the sequential function of scf complexes containing distinct hcdc4 isoforms Academic Article
Ultra-potent antibodies against respiratory syncytial virus: effects of binding kinetics and binding valence on viral neutralization Academic Article
Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier Academic Article
Ultrahigh and high resolution structures and mutational analysis of monomeric streptococcus pyogenes speb reveal a functional role for the glycine-rich c-terminal loop Academic Article
Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection Academic Article
Understanding the enzymatic activity of 4-oxalocrotonate tautomerase and its mutant analogues: A computational study Academic Article
Unfolded proteins and protein folding studied by NMR Academic Article
Unique domain appended to vertebrate tRNA synthetase is essential for vascular development Academic Article
Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations Academic Article
Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene Academic Article
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded rna occurs by trif-dependent and trif-independent pathways Academic Article
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in plasmodium falciparum Academic Article
Use of silent mutations in cDNA encoding human glutathione transferase M2-2 for optimized expression in Escherichia coli Academic Article
Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors Academic Article
VH11 bias and normal V-D-J junctions in SCID B lymphocytes rescued by neonatal T cell transfer Academic Article
VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses Academic Article
Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention Academic Article
Validation of isoleucine utilization targets in plasmodium falciparum Academic Article
Variability of thrombosis among homozygous siblings with resistance to activated protein-C due to an Arg- Gln mutation in the gene for factor-V Academic Article
Variable region sequences of murine igm anti-igg monoclonal autoantibodies (rheumatoid factors) - a structural explanation for the high-frequency of igm anti-igg b-cells Academic Article
Vav and ras induce fibroblast transformation by overlapping signaling pathways, which require c-myc function Academic Article
Velvet, a dominant egfr mutation that causes wavy hair and defective eyelid development in mice Academic Article
Viral mutations, TCR antagonism and escape from the immune-response Academic Article
Virus lymphocyte interactions .4. Molecular characterization of lcmv armstrong (ctl+) small genomic segment and that of its variant, clone-13 (ctl-) Academic Article
Virus maturation targets the protein capsid to concerted disassembly and unfolding Academic Article
Virus persistence and recurring demyelination produced by a temperature-sensitive mutant of mhv-4 Academic Article
Virus-induced immunosuppression - kinetic-analysis of the selection of a mutation associated with viral persistence Academic Article
Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide Academic Article
Whi5 regulation by site specific cdk-phosphorylation in saccharomyces cerevisiae Academic Article
Whole-genome mutational burden analysis of three pluripotency induction methods Academic Article
Whole-genome sequencing and microarray analysis of ex vivo plasmodium vivax reveal selective pressure on putative drug resistance genes Academic Article
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C Academic Article
Xenobiotic metabolism and mutation in a human lymphoblastoid cell line Academic Article
Xpd helicase structures and activities: Insights into the cancer and aging phenotypes from xpd mutations Academic Article
Yeast LEU5 is a PET-like gene that is not essential for leucine biosynthesis Academic Article
Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice Academic Article
ZBTB1 is a determinant of lymphoid development Academic Article
Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates. A mini-review Academic Article
hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene Academic Article
hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function Academic Article
kurtz, a novel nonvisual arrestin, is an essential neural gene in Drosophila Academic Article
l(3)malignant brain tumor and three novel genes are required for Drosophila germ-cell formation Academic Article
roX1 RNA paints the X chromosome of male Drosophila and is regulated by the dosage compensation system Academic Article
tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the Arabidopsis circadian oscillator Academic Article
β-hairpin-mediated nucleation of polyglutamine amyloid formation Academic Article

Scripps VIVO

Mutation

Overview

subject area of