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  • "Resistance" to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 do not confer resistance  Academic Article
  • 'Late onset' ornithine transcarbamylase deficiency: function of three purified recombinant mutant enzymes  Academic Article
  • 3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting  Academic Article
  • 5' cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved 5' GU  Academic Article
  • A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2  Academic Article
  • A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon  Academic Article
  • A CCHC metal-binding domain in Nanos is essential for translational regulation  Academic Article
  • A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response  Academic Article
  • A Saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability  Academic Article
  • A THEMIS:SHP1 complex promotes T-cell survival  Academic Article
  • A bacterial amber suppressor in Saccharomyces cerevisiae is selectively recognized by a bacterial aminoacyl-tRNA synthetase  Academic Article
  • A base change in the catalytic core of the hairpin ribozyme perturbs function but not domain docking  Academic Article
  • A base triple in the tetrahymena group i core affects the reaction equilibrium via a threshold effect  Academic Article
  • A c-alpha model for the transmembrane alpha helices of gap junction intercellular channels  Academic Article
  • A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase  Academic Article
  • A cell cycle phosphoproteome of the yeast centrosome  Academic Article
  • A cell-autonomous requirement for the cell cycle regulatory protein, rb, in neuronal migration  Academic Article
  • A cell-cycle checkpoint monitors cell morphogenesis in budding yeast  Academic Article
  • A chemical chaperone decouples TDP-43 disordered domain phase separation from fibrillation  Academic Article
  • A chemical toolkit for proteins: an expanded genetic code  Academic Article
  • A chiroselective peptide replicator  Academic Article
  • A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease  Academic Article
  • A clonal analysis of tergite development in Drosophila of ultraabdominal and paradoxical genotypes  Academic Article
  • A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells  Academic Article
  • A conservative isoleucine to leucine mutation causes major rearrangements and cold sensitivity in KlenTaq1 DNA polymerase  Academic Article
  • A conserved family of prolyl-4-hydroxylases that modify HIF  Academic Article
  • A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins  Academic Article
  • A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension  Academic Article
  • A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function  Academic Article
  • A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development  Academic Article
  • A covering method for detecting genetic associations between rare variants and common phenotypes  Academic Article
  • A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells  Academic Article
  • A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics  Academic Article
  • A crucial role for the putative Arabidopsis topoisomerase VI in plant growth and development  Academic Article
  • A de novo designed peptide ligase: A mechanistic investigation  Academic Article
  • A de novo protein binding pair by computational design and directed evolution  Academic Article
  • A designed inhibitor of a CLC antiporter blocks function through a unique binding mode  Academic Article
  • A di-acidic (DxE) code directs concentration of cargo during export from the endoplasmic reticulum  Academic Article
  • A di-acidic signal required for selective export from the endoplasmic reticulum  Academic Article
  • A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase  Academic Article
  • A distinct set of drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory  Academic Article
  • A dominant negative mutant of the E. Coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit  Academic Article
  • A dominant-negative peroxisome proliferator-activated receptor gamma (ppar gamma) mutant is a constitutive repressor and inhibits ppar gamma-mediated adipogenesis  Academic Article
  • A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory  Academic Article
  • A dynamin mutant defines a superconstricted prefission state  Academic Article
  • A family of cyclin homologs that control the g1 phase in yeast  Academic Article
  • A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity  Academic Article
  • A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function  Academic Article
  • A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity  Academic Article
  • A general method for greatly improving the affinity of antibodies by using combinatorial libraries  Academic Article
  • A general method for site-specific incorporation of unnatural amino acids into proteins  Academic Article
  • A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers  Academic Article
  • A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase  Academic Article
  • A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe  Academic Article
  • A glutamate switch controls voltage-sensitive phosphatase function  Academic Article
  • A growth regulatory loop that provides homeostasis to phytochrome A signaling  Academic Article
  • A guanosine to adenosine transition in the 3' terminal extracistronic region of bacteriophage Qβ RNA leading to loss of infectivity  Academic Article
  • A helix replacement mechanism directs metavinculin functions  Academic Article
  • A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B  Academic Article
  • A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion  Academic Article
  • A highly conserved neutralizing epitope on group 2 influenza a viruses  Academic Article
  • A highly membrane-active peptide in Flock House virus: Implications for the mechanism of nodavirus infection  Academic Article
  • A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1  Academic Article
  • A human germ line antibody light chain with hydrolytic properties associated with multimerization status  Academic Article
  • A humanized anti-4-1bb monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates  Academic Article
  • A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd  Academic Article
  • A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses  Academic Article
  • A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41  Academic Article
  • A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa  Academic Article
  • A membrane-embedded amino acid couples the SpoIIQ channel protein to anti-sigma factor transcriptional repression during Bacillus subtilis sporulation  Academic Article
  • A metal-binding motif implicated in RNA recognition by an aminoacyl-tRNA synthetase and by a retroviral gene product  Academic Article
  • A method to site-specifically introduce methyllysine into proteins in E. coli  Academic Article
  • A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron  Academic Article
  • A missense mutation in the neutrophil cytochrome-b heavy-chain in cytochrome-positive x-linked chronic granulomatous-disease  Academic Article
  • A molecular description of the evolution of resistance  Academic Article
  • A molecular switch regulating transcriptional repression and activation of PPARγ  Academic Article
  • A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration  Academic Article
  • A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks  Academic Article
  • A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response  Academic Article
  • A mutant of rous sarcoma virus (type o) causing fusiform cell transformation  Academic Article
  • A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function  Academic Article
  • A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome  Academic Article
  • A mutation in the FHA domain of Coprinus cinereus Nbs1 leads to Spo11-independent meiotic recombination and chromosome segregation  Academic Article
  • A mutation in the human cyclin-dependent kinase interacting protein, ckshs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly  Academic Article
  • A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters  Academic Article
  • A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα  Academic Article
  • A new regulatory switch in a JAK protein kinase  Academic Article
  • A new strategy for the synthesis of glycoproteins  Academic Article
  • A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis  Academic Article
  • A note on efficient estimation of mutation-rates using luria-delbruck fluctuation analysis  Academic Article
  • A novel GJA8 mutation (p.V44A) causing autosomal dominant congenital cataract  Academic Article
  • A novel cross-talk in diacylglycerol signaling the rac-gap beta 2-chimaerin is negatively regulated by protein kinase c delta-mediated phosphorylation  Academic Article
  • A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex  Academic Article
  • A novel promoter motif for caulobacter cell cycle-controlled DNA replication genes  Academic Article
  • A novel splice acceptor site mutation which produces multiple splicing abnormalities resulting in protein S deficiency type I  Academic Article
  • A novel technique for the rapid preparation of mutant RNAs  Academic Article
  • A nucleoside transporter from Trypanosoma brucei involved in drug resistance  Academic Article
  • A p47-phox pseudogene carries the most common mutation causing p47-phox-deficient chronic granulomatous disease  Academic Article
  • A perspective on the structural and functional constraints for immune evasion: insights from influenza virus  Academic Article
  • A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins  Academic Article
  • A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor  Academic Article
  • A plasma membrane H(+)-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana  Academic Article
  • A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield  Academic Article
  • A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins  Academic Article
  • A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.Fem-3 mRNA complex  Academic Article
  • A putative bacterial ABC transporter circumvents the essentiality of signal peptidase  Academic Article
  • A quick diversity-oriented amide-forming reaction to optimize p-subsite residues of hiv protease inhibitors  Academic Article
  • A rab1 mutant affecting guanine-nucleotide exchange promotes disassembly of the golgi-apparatus  Academic Article
  • A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin  Academic Article
  • A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90  Academic Article
  • A role for brassinosteroids in light-dependent development of Arabidopsis  Academic Article
  • A role for dual viral hits in causation of subacute sclerosing panencephalitis  Academic Article
  • A role for flavin monooxygenase-like enzymes in auxin biosynthesis  Academic Article
  • A role for peroxisomes in photomorphogenesis and development of Arabidopsis  Academic Article
  • A role for the P-body component GW182 in microRNA function  Academic Article
  • A role for the swe1 checkpoint kinase during filamentous growth of saccharomyces cerevisiae  Academic Article
  • A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib  Academic Article
  • A role of the kinase mtor in cellular transformation induced by the oncoproteins p3k and akt  Academic Article
  • A selective chemical probe for coenzyme a - requiring enzymes  Academic Article
  • A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo  Academic Article
  • A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth  Academic Article
  • A siglec-like sialic-acid-binding motif revealed in an adenovirus capsid protein  Academic Article
  • A silencer element in the retinoblastoma tumor-suppressor gene  Academic Article
  • A simple structural feature is a major determinant of the identity of a transfer RNA  Academic Article
  • A single amino-acid change in the mouse peroxisome proliferator-activated receptor-alpha alters transcriptional responses to peroxisome proliferators  Academic Article
  • A single base pair affects binding and catalytic parameters in the molecular recognition of a transfer RNA  Academic Article
  • A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression  Academic Article
  • A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouse  Academic Article
  • A sphingosine 1-phosphate receptor 2 selective allosteric agonist  Academic Article
  • A structural view of evolutionary divergence  Academic Article
  • A study of genes that may modulate the expression of hereditary hemochromatosis: Transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (irp)-1 and-2, and hepcidin  Academic Article
  • A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase  Academic Article
  • A temperature-sensitive lesion affecting levels of transformation-specific viral RNA in a mutant of avian sarcoma virus PRCII  Academic Article
  • A transcriptional repressor obtained by alternative translation of a trinucleotide repeat  Academic Article
  • A two-component signal transduction system essential for growth of bacillus subtilis: Implications for anti-infective therapy  Academic Article
  • A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5  Academic Article
  • A unique gtp-dependent sporulation sensor histidine kinase in bacillus anthracis  Academic Article
  • A virus-based nanoblock with tunable electrostatic properties  Academic Article
  • ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair  Academic Article
  • ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC  Academic Article
  • AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin  Academic Article
  • ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization  Academic Article
  • ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import  Academic Article
  • ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1  Academic Article
  • Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine  Academic Article
  • Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells  Academic Article
  • Accessory mutations maintain stability in drug-resistant HIV-1 protease  Academic Article
  • Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae  Academic Article
  • Acidic food pH increases palatability and consumption and extends drosophila lifespan  Academic Article
  • Acidification of endosome subpopulations in wild-type chinese-hamster ovary cells and temperature-sensitive acidification-defective mutants  Academic Article
  • Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering  Academic Article
  • Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions  Academic Article
  • Activated protein C resistance caused by Arg506Gln mutation in factor Va  Academic Article
  • Activated protein C variants with normal cytoprotective but reduced anticoagulant activity  Academic Article
  • Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe  Academic Article
  • Activation domain-dependent monoubiquitylation of Gal4 protein is essential for promoter binding in vivo  Academic Article
  • Activation of snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos  Academic Article
  • Activation of tumor cell integrin alpha(v)beta(3) controls angiogenesis and metastatic growth in the brain  Academic Article
  • Activation tagging of the floral inducer FT  Academic Article
  • Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast  Academic Article
  • Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein  Academic Article
  • Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties  Academic Article
  • Active site residues of cyclophilin A are crucial for its signaling activity via CD147  Academic Article
  • Active site serine promotes stabilization of the reactive glutathione thiolate in rat glutathione transferase T2-2 - Evidence against proposed sulfatase activity of the corresponding human enzyme  Academic Article
  • Active, interactive, and inactive steroid-receptor mutants  Academic Article
  • Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3  Academic Article
  • Activity of yeast extracts in cell-free stimulation of DNA-replication  Academic Article
  • Activity-guided engineering of natural product carrier proteins  Academic Article
  • Adaptive mutations alter antibody structure and dynamics during affinity maturation  Academic Article
  • Adenovirus core protein pvii is translocated into the nucleus by multiple import receptor pathways  Academic Article
  • Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by rho family gtpases  Academic Article
  • Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice  Academic Article
  • Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie b-adenovirus receptor-bearing cells  Academic Article
  • Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae  Academic Article
  • Adult chicken alpha-globin gene-expression in transfected qt6 quail cells - evidence for a negative regulatory element in the alpha-d gene region  Academic Article
  • Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling  Academic Article
  • Age-related somatic structural changes in the nuclear genome of human blood cells  Academic Article
  • Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes  Academic Article
  • Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA  Academic Article
  • All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase  Academic Article
  • Alloreactive T cells discriminate among a diverse set of endogenous peptides  Academic Article
  • Alteration of bacillus-subtilis glutamine-synthetase results in overproduction of enzyme  Academic Article
  • Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant  Academic Article
  • Alteration of the reduction potential of the 4fe-4s (2+/+) cluster of azotobacter vinelandii ferredoxin i  Academic Article
  • Alteration of the α-synuclein folding landscape by a mutation related to Parkinson's disease  Academic Article
  • Alterations in the flow of one-carbon units affect kinb-dependent sporulation in bacillus subtilis  Academic Article
  • Altered chaperone-like activity of α-crystallins promotes cataractogenesis  Academic Article
  • Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system  Academic Article
  • Altered mRNA binding activity and decreased translation initiation in a nuclear mutant lacking translation of the chloroplast psbA mRNA  Academic Article
  • Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery  Academic Article
  • Alternative mutations of a positively selected residue elicit qain or loss of functionalities in enzyme evolution  Academic Article
  • Alternative outcomes in assembly of promoter complexes: The roles of TBP and a flexible linker in placing TFIIIB on tRNA genes  Academic Article
  • Alternative splicing within the ligand binding domain of the human constitutive androstane receptor  Academic Article
  • Alzheimer's Aβ peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)?  Academic Article
  • American College of Medical Genetics consensus statement on factor V Leiden mutation testing  Academic Article
  • Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase  Academic Article
  • Amino acid substitution at the dimeric interface of human manganese superoxide dismutase  Academic Article
  • Amino-acid replacements that compensate for a large polypeptide deletion in an enzyme  Academic Article
  • Aminoacyl tRNA synthetases and their connections to disease  Academic Article
  • Aminoacyl-tRNA synthetases: general features and recognition of transfer RNAs  Academic Article
  • Amplification, mutation and selection of catalytic RNA  Academic Article
  • Amplification, rearrangement, and elevated expression of c-myc in the human prostatic carcinoma cell line LNCaP  Academic Article
  • Amyloid diseases: Abnormal protein aggregation in neurodegeneration  Academic Article
  • Amyotrophic Lateral Sclerosis  Academic Article
  • Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase  Academic Article
  • An Arabidopsis mutant defective in the plastid general protein import apparatus  Academic Article
  • An Arabidopsis thaliana virescent mutant reveals a role for ClpR1 in plastid development  Academic Article
  • An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence  Academic Article
  • An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors  Academic Article
  • An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide  Academic Article
  • An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway  Academic Article
  • An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model  Academic Article
  • An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening  Academic Article
  • An association of candidate gene haplotypes and bleeding severity in von willebrand disease type 2a, 2b, and 2m pedigrees  Academic Article
  • An engineered virus as a scaffold for three-dimensional self-assembly on the nanoscale  Academic Article
  • An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes  Academic Article
  • An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses  Academic Article
  • An essential GTpase promotes assembly of preribosomal RNA processing complexes  Academic Article
  • An essential g1 function for cyclin-like proteins in yeast  Academic Article
  • An expanded eukaryotic genetic code  Academic Article
  • An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system  Academic Article
  • An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae  Academic Article
  • An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5  Academic Article
  • An intact conformation at the tip of elongation factor G domain IV is functionally important  Academic Article
  • An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity  Academic Article
  • An interchromosomal gene conversion of the Drosophila dunce locus identified with restriction site polymorphisms: a potential involvement of transposable elements in gene conversion  Academic Article
  • An intracellular signal transduction pathway between the chloroplast and nucleus is involved in de-etiolation  Academic Article
  • An isogenic human ESC platform for functional evaluation of genome-wide-association-study-identified diabetes genes and drug discovery  Academic Article
  • An mrna-rrna base-pairing mechanism for translation initiation in eukaryotes  Academic Article
  • An online resource for GPCR structure determination and analysis  Academic Article
  • An orthogonal DNA replication system in yeast  Academic Article
  • An unexpected outcome of surface engineering an integral membrane protein: Improved crystallization of cytochrome ba(3) from thermus thermophilus  Academic Article
  • Analysis by electron-microscopy of early simian-virus 40 rna from a tsa mutant  Academic Article
  • Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries  Academic Article
  • Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor  Academic Article
  • Analysis of individual immunoglobulin-lambda light-chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center b-cell somatic mutation  Academic Article
  • Analysis of male pheromones that accelerate female reproductive organ development  Academic Article
  • Analysis of novel residues of class I involved in recognition by alloreactive T cells  Academic Article
  • Analysis of rrna processing and translation in mammalian cells using a synthetic 18s rrna expression system  Academic Article
  • Analysis of stop-gain and frameshift variants in human innate immunity genes  Academic Article
  • Analyzing and tuning ribozyme activity by deep sequencing to modulate gene expression level in mammalian cells  Academic Article
  • Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase  Academic Article
  • Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity  Academic Article
  • Antibodies against small nuclear ribonucleoproteins immunoprecipitate complexes containing ts110 Moloney murine sarcoma virus genomic and messenger RNAs  Academic Article
  • Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics  Academic Article
  • Antigen presentation and t cell development in h2-m-deficient mice  Academic Article
  • Antigen-driven B cell differentiation in vivo  Academic Article
  • Antigenic analyses of influenza-virus hemagglutinins with different receptor-binding specificities  Academic Article
  • Antisense masking reveals contributions of mrna- rrna base pairing to translation of gtx and fgf2 mrnas  Academic Article
  • Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors  Academic Article
  • Application of site-directed mutagenesis to rna and DNA genomes  Academic Article
  • Approaches for skeletal gene therapy  Academic Article
  • Arabidopsis MYB30 is a direct target of BES1 and cooperates with BES1 to regulate brassinosteroid-induced gene expression  Academic Article
  • Arabidopsis thaliana mutant that develops as a light-grown plant in the absence of light  Academic Article
  • Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation  Academic Article
  • Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors  Academic Article
  • Architecture of the flagellar rotor  Academic Article
  • Arenavirus diversity and evolution: Quasispecies in vivo  Academic Article
  • Arenavirus extinction through lethal mutagenesis  Academic Article
  • Aromatic residues in the C-terminal region of glutathione transferase A1-1 influence rate-determining steps in the catalytic mechanism  Academic Article
  • Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein  Academic Article
  • Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase  Academic Article
  • Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility  Academic Article
  • Assembly of the covalent linkage between lipoic acid and its cognate enzymes  Academic Article
  • Assignment of the L30-mRNA complex using selective isotopic labeling and RNA mutants  Academic Article
  • Association between a disrupted-in-schizophrenia 1 (disc1) single nucleotide polymorphism and schizophrenia in a combined scandinavian case-control sample  Academic Article
  • Association between thromboembolic events and the JAK2 V617F mutation in myeloproliferative neoplasms  Academic Article
  • Association of the 2-mu-m DNA plasmid with yeast folded chromosomes  Academic Article
  • Associations between phylogenetic clustering and HLA profile among HIV-infected individuals in San Diego, California  Academic Article
  • Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificities  Academic Article
  • Atl1 regulates choice between global genome and transcription-coupled repair of o-6-alkylguanines  Academic Article
  • Atomic accuracy in predicting and designing noncanonical RNA structure  Academic Article
  • Atomic structures of wild-type and thermostable mutant recombinant human cu,zn superoxide-dismutase  Academic Article
  • Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex  Academic Article
  • Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface  Academic Article
  • Autoantibodies as reporters identifying aberrant cellular mechanisms in tumorigenesis  Academic Article
  • Automated analysis of hypocotyl growth dynamics during shade avoidance in Arabidopsis  Academic Article
  • Automated identification of functional dynamic contact networks from X-ray crystallography  Academic Article
  • Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity  Academic Article
  • Autoproteolysis in nucleoporin biogenesis  Academic Article
  • Autoregulation of simian virus-40 gene-a by t-antigen  Academic Article
  • Avian-sarcoma virus mutant that is temperature sensitive for virion assembly  Academic Article
  • Avian-sarcoma virus prcii - conditional mutants temperature sensitive in the maintenance of fibroblast transformation  Academic Article
  • Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential  Academic Article
  • BACE1- and BACE2-expressing human cells - characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors  Academic Article
  • BAS1: A gene regulating brassinosteroid levels and light responsiveness in Arabidopsis  Academic Article
  • BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice  Academic Article
  • BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation  Academic Article
  • BIG: a calossin-like protein required for polar auxin transport in Arabidopsis  Academic Article
  • BIN2, a new brassinosteroid-insensitive locus in Arabidopsis  Academic Article
  • BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis  Academic Article
  • BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis  Academic Article
  • BRANCHED1 interacts with FLOWERING LOCUS T to repress the floral transition of the axillary meristems in Arabidopsis  Academic Article
  • BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint  Academic Article
  • BRI1 is a critical component of a plasma-membrane receptor for plant steroids  Academic Article
  • BRL1 and BRL3 are novel brassinosteroid receptors that function in vascular differentiation in Arabidopsis  Academic Article
  • Bacillus subtilis chec and fliy are members of a novel class of chey-p-hydrolyzing proteins in the chemotactic signal transduction cascade  Academic Article
  • Backbone-backbone H-bonds make context-dependent contributions to protein folding kinetics and thermodynamics: lessons from amide-to-ester mutations  Academic Article
  • Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin  Academic Article
  • Balanced electrostatic and structural forces guide the large conformational change associated with maturation of t=4 virus  Academic Article
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  • Deep mutational scanning: assessing protein function on a massive scale  Academic Article
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  • Fine definition of the CXCR4-binding region on the V3 loop of feline immunodeficiency virus surface glycoprotein  Academic Article
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  • GIGANTEA directly activates Flowering Locus T in Arabidopsis thaliana  Academic Article
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  • Generation of a Ni(II) binding site by introduction of a histidine cluster in the structure of human glutathione transferase A1-1  Academic Article
  • Generation of a catalytic antibody by site-directed mutagenesis  Academic Article
  • Generation of a catalytic sequence-specific hybrid DNase  Academic Article
  • Generation of a hybrid sequence-specific single-stranded deoxyribonuclease  Academic Article
  • Generation of mutation hotspots in ageing bacterial colonies  Academic Article
  • Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration  Academic Article
  • Genetic ablation of a mouse gene expressed specifically in brain  Academic Article
  • Genetic abnormalities and juvenile hemochromatosis: Mutations of the hjv gene encoding hemojuvelin  Academic Article
  • Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines  Academic Article
  • Genetic analysis of cyclic nucleotide phosphodiesterases in Drosophila melanogaster  Academic Article
  • Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large  Academic Article
  • Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles  Academic Article
  • Genetic analysis of innate immunity: Identification and function of the tir adapter proteins  Academic Article
  • Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV)  Academic Article
  • Genetic analysis of pleiotropic negative sporulation mutants in bacillus subtilis  Academic Article
  • Genetic analysis of resistance to viral infection  Academic Article
  • Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis  Academic Article
  • Genetic and biochemical characterization of mutants of bacillus-subtilis defective in succinate dehydrogenase  Academic Article
  • Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development  Academic Article
  • Genetic basis of tetrodotoxin resistance in pufferfishes  Academic Article
  • Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases  Academic Article
  • Genetic disorders associated with atp binding cassette cholesterol transporters  Academic Article
  • Genetic dissection of innate immunity to infection: The mouse cytomegalovirus model  Academic Article
  • Genetic diversity of EBV-encoded LMP1 in the Swiss HIV Cohort Study and implication for NF-Κb activation  Academic Article
  • Genetic incorporation of histidine derivatives using an engineered pyrrolysyl-tRNA synthetase  Academic Article
  • Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis  Academic Article
  • Genetic interaction landscape reveals critical requirements for Schizosaccharomyces pombe Brc1 in DNA damage response mutants  Academic Article
  • Genetic interactions between phytochrome A, phytochrome B, and cryptochrome 1 during Arabidopsis development  Academic Article
  • Genetic localization and molecular characterization of the nons gene required for macrotetrolide biosynthesis in streptomyces griseus dsm40695  Academic Article
  • Genetic mutations in ten unrelated american patients with symptomatic type-1 protein-C deficiency  Academic Article
  • Genetic recombinants and heterozygotes derived from endogenous and exogenous avian RNA tumor viruses  Academic Article
  • Genetic screening for low-penetrance variants in protein-coding genes  Academic Article
  • Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300  Academic Article
  • Genetic variation in an individual human exome  Academic Article
  • Genetic-analysis in bacillus-subtilis  Academic Article
  • Genetic-analysis of a class of polymyxin resistant partial revertants of stage-o sporulation mutants of bacillus-subtilis - map of the chromosome region near the origin of replication  Academic Article
  • Genetic-mapping of a linked cluster of ribosomal ribonucleic-acid genes in bacillus-subtilis  Academic Article
  • Genetically engineered polymers of human Cu Zn superoxide-dismutase - biochemistry and serum half-lives  Academic Article
  • Genetics of alpha-ketoglutarate dehydrogenase complex of bacillus-subtilis  Academic Article
  • Genetics of bacillus-subtilis chemotaxis - isolation and mapping of mutations and cloning of chemotaxis genes  Academic Article
  • Genetics of bacterial sporulation  Academic Article
  • Genome-wide association study identifies five new schizophrenia loci  Academic Article
  • Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior  Academic Article
  • Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome  Academic Article
  • Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma  Academic Article
  • Genomic sequence of the dax1 gene: An orphan nuclear receptor responsible for x-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism  Academic Article
  • Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak  Academic Article
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  • Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates alzheimer's disease-related neuropathies: Involvement of non-amyloidogenic processing  Academic Article
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  • Global analysis of protein palmitoylation in yeast  Academic Article
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  • Glutathione precursors replenish decreased glutathione pool in cystinotic cell lines  Academic Article
  • Glutathione transferase A1-1: catalytic importance of arginine 15  Academic Article
  • Glutathione transferase P1-1 expression in human melanoma metastases: correlation to N-RAS mutations and expression  Academic Article
  • Glutathione transferases with novel active sites isolated by phage display from a library of random mutants  Academic Article
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  • Glycolipids of chick-embryo fibroblasts infected with temperature-sensitive mutants of avian-sarcoma viruses  Academic Article
  • Glycoproteins of plasma-membrane of dictyostelium discoideum during development  Academic Article
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  • HCV core residues critical for infectivity are also involved in core-NS5A complex formation  Academic Article
  • HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogene  Academic Article
  • HIV-1 entry and macrophage inflammatory protein-1 beta-mediated signaling are independent functions of the chemokine receptor CCR5  Academic Article
  • Haematological effects of the c282yhfe mutation in homozygous and heterozygous states among subjects of northern and southern european ancestry  Academic Article
  • Haemolytic onset of Wilson disease in a patient with homozygous truncation of ATP7B at Arg1319  Academic Article
  • Haptoglobin polymorphism and iron homeostasis  Academic Article
  • Harmonin mutations cause mechanotransduction defects in cochlear hair cells  Academic Article
  • Hcdc4 gene mutations in endometrial cancer  Academic Article
  • Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores  Academic Article
  • Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli  Academic Article
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  • Helical crystallization on nickel–lipid nanotubes: Perfringolysin O as a model protein  Academic Article
  • Helical domain and kinase domain mutations in p110 alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms  Academic Article
  • Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins b cell linker protein and slp-76 in lymphocytes  Academic Article
  • Heme synthesis by plastid ferrochelatase I regulates nuclear gene expression in plants  Academic Article
  • Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection  Academic Article
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  • Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe  Academic Article
  • Human f-box protein hcdc4 targets cyclin e for proteolysis and is mutated in a breast cancer cell line  Academic Article
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  • Human germline antibody gene segments encode polyspecific antibodies  Academic Article
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  • Human rhinovirus capsid dynamics is controlled by canyon flexibility  Academic Article
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  • Identification of a cdk-activating kinase in fission yeast  Academic Article
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  • Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers  Academic Article
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  • Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase  Academic Article
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  • Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck  Academic Article
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  • Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo  Academic Article
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  • Mechanism of activation of protein kinase JAK2 by the growth hormone receptor  Academic Article
  • Mechanism of human antibody-mediated neutralization of Marburg virus  Academic Article
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  • Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations  Academic Article
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  • Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase  Academic Article
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  • Microbial source tracking by DNA sequence analysis of the Escherichia coli malate dehydrogenase gene  Academic Article
  • Microdroplet-based pcr enrichment for large-scale targeted sequencing  Academic Article
  • Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features  Academic Article
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  • Mitochondrial fission in apoptosis, neurodegeneration and aging  Academic Article
  • Mitotic misregulation and human aging  Academic Article
  • Mitotic role for the cdc28-protein kinase of saccharomyces-cerevisiae  Academic Article
  • Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe  Academic Article
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  • Modeling the evolution of drug resistance in malaria  Academic Article
  • Modeling the inhibition of quadruple mutant Plasmodium falciparum dihydrofolate reductase by pyrimethamine derivatives  Academic Article
  • Modeling with in vitro kinetic parameters for the elaboration of transfer RNA identity in vivo  Academic Article
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  • Modulation of HIF-2α PAS-B domain contributes to physiological responses  Academic Article
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  • Modulation of brassinosteroid-regulated gene expression by jumonji domain-containing proteins ELF6 and REF6 in Arabidopsis  Academic Article
  • Modulation of fluorescent protein chromophores to detect protein aggregation with turn-on fluorescence  Academic Article
  • Modulation of rac localization and function by dynamin  Academic Article
  • Modulation of substrate specificities of D-sialic acid aldolase through single mutations of Val-251  Academic Article
  • Modulation of the SecY channel permeability by pore mutations and trivalent cations  Academic Article
  • Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control  Academic Article
  • Molecular basis of seasonal time measurement in Arabidopsis  Academic Article
  • Molecular basis of viral persistence: a single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence  Academic Article
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  • Molecular characterization of single memory b-cells  Academic Article
  • Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions  Academic Article
  • Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo - Rab-independent binding to membranes and role of Rab recycling factors  Academic Article
  • Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents  Academic Article
  • Molecular evolution of the Rab-escort-protein/guanine-nucleotide-dissociation-inhibitor superfamily  Academic Article
  • Molecular genetics of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency  Academic Article
  • Molecular genetics of transmissible spongiform encephalopathies  Academic Article
  • Molecular mechanism of the sweet taste enhancers  Academic Article
  • Molecular mechanisms of myocardial infarction  Academic Article
  • Molecular methods for isolation of signal transduction pathway mutants  Academic Article
  • Molecular pathogenesis of cystinosis: Effect of ctns mutations on the transport activity and subcellular localization of cystinosin  Academic Article
  • Molecular role for the Rab binding platform of guanine nucleotide dissociation inhibitor in endoplasmic reticulum to Golgi transport  Academic Article
  • Molecular-biology approaches to genetic-defects of the mammalian nervous-system  Academic Article
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  • Mouse hematopoietic stem-cells  Academic Article
  • Mouse hematopoietic stem-cells and the interaction of c-kit receptor and steel factor  Academic Article
  • Mouse model of subretinal neovascularization with choroidal anastomosis  Academic Article
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  • The anticoagulant function of coagulation factor v  Academic Article
  • The bacillus subtilis genes for ribonucleotide reductase are similar to the genes for the second class i nrde/nrdf enzymes of enterobacteriaceae  Academic Article
  • The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12  Academic Article
  • The carboxy terminus of the viral jun oncoprotein is required for complex-formation with the cellular fos protein  Academic Article
  • The catalytic site of cytochrome P4504A11 (CYP4A11) and its L131F mutant  Academic Article
  • The catalytic subunit of phosphoinositide 3-kinase: Requirements for oncogenicity  Academic Article
  • The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium  Academic Article
  • The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins  Academic Article
  • The cbpa gene - role of the 26,000-dalton carbohydrate-binding protein in inter-cellular cohesion of developing dictyostelium-discoideum cells  Academic Article
  • The chemistry of the antibody molecule  Academic Article
  • The clinical continuum of cryopyrinopathies - Novel CIAS1 mutations in north American patients and a new cryopyrin model  Academic Article
  • The co-ordination of nuclear and organellar genome expression in eukaryotic cells  Academic Article
  • The complete genome sequences, unique mutational spectra, and developmental potency of adult neurons revealed by cloning  Academic Article
  • The consensus sequence ygtgttyy located downstream from the aataaa signal is required for efficient formation of messenger-rna 3' termini  Academic Article
  • The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability  Academic Article
  • The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase  Academic Article
  • The critical role of membralin in postnatal motor neuron survival and disease  Academic Article
  • The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity  Academic Article
  • The cyclic AMP phosphodiesterase encoded by the Drosophila dunce gene is concentrated in the mushroom body neuropil  Academic Article
  • The cytochrome ba(3) oxygen reductase from thermus thermophilus uses a single input channel for proton delivery to the active site and for proton pumping  Academic Article
  • The dachshund gene is required for the proper guidance and branching of mushroom body axons in Drosophila melanogaster  Academic Article
  • The designability of protein switches by chemical rescue of structure: mechanisms of inactivation and reactivation  Academic Article
  • The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase  Academic Article
  • The deubiquitinating enzyme AMSH3 is required for intracellular trafficking and vacuole biogenesis in Arabidopsis thaliana  Academic Article
  • The dissection and engineering of sites that affect the activity of an enzyme of unknown structure  Academic Article
  • The effect of supercoiling on the in vitro transcription of the spoIIA operon from Bacillus subtilis  Academic Article
  • The effects of ionic strength on protein stability: the cold shock protein family  Academic Article
  • The end-joining reaction in V(D)J recombination  Academic Article
  • The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism  Academic Article
  • The enterococcus faecalis fsr two-component system controls biofilm development through production of gelatinase  Academic Article
  • The epidermis both drives and restricts plant shoot growth  Academic Article
  • The ermC leader peptide: amino acid alterations leading to differential efficiency of induction by macrolide-lincosamide-streptogramin B antibiotics  Academic Article
  • The evolutionarily conserved residue A653 plays a key role in HERG channel closing  Academic Article
  • The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis  Academic Article
  • The fibrillin-1 gene: Unlocking new therapeutic pathways in cardiovascular disease  Academic Article
  • The folding mechanism of a beta-sheet: the WW domain  Academic Article
  • The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity  Academic Article
  • The genes for myelin revisited  Academic Article
  • The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb  Academic Article
  • The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation  Academic Article
  • The hydrophobic patch of ubiquitin is required to protect transactivator-promoter complexes from destabilization by the proteasomal atpases  Academic Article
  • The immunological evolution of catalysis  Academic Article
  • The influence of adenovirus fiber structure and function on vector development for gene therapy  Academic Article
  • The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1  Academic Article
  • The integrity of the cysteine-186-cysteine-209 bond of the 2nd disulfide loop of tissue factor is required for binding of factor-vii  Academic Article
  • The internal ribosome entry site (ires) contained within the rna-binding motif protein 3 (rbm3) mrna is composed of functionally distinct elements  Academic Article
  • The interplay between binding energy and catalysis in the evolution of a catalytic antibody  Academic Article
  • The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain  Academic Article
  • The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes  Academic Article
  • The long-term memory trace formed in the Drosophila α/β mushroom body neurons is abolished in long-term memory mutants  Academic Article
  • The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1  Academic Article
  • The maltose ABC transporter: Action of membrane lipids on the transporter stability, coupling and ATPase activity  Academic Article
  • The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos  Academic Article
  • The membrane subunit nuol(nd5) is involved in the indirect proton pumping mechanism of escherichia coli complex i  Academic Article
  • The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis  Academic Article
  • The molecular chaperone Hsp90α is required for meiotic progression of spermatocytes beyond pachytene in the mouse  Academic Article
  • The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway  Academic Article
  • The novel ets factor tel2 cooperates with myc in b lymphomagenesis  Academic Article
  • The oligopeptide transport-system of bacillus-subtilis plays a role in the initiation of sporulation  Academic Article
  • The oncogenicity of jun  Academic Article
  • The organization of endoplasmic reticulum export complexes  Academic Article
  • The pathogenesis of transthyretin tissue deposition: Lessons from transgenic mice  Academic Article
  • The pds1 anaphase inhibitor and mec1 kinase define distinct checkpoints coupling s phase with mitosis in budding yeast  Academic Article
  • The phenotype of Arabidopsis thaliana det1 mutants suggests a role for cytokinins in greening  Academic Article
  • The phosphoenolpyruvate/phosphate translocator is required for phenolic metabolism, palisade cell development, and plastid-dependent nuclear gene expression  Academic Article
  • The polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo  Academic Article
  • The product of the natural reaction catalyzed by 4-oxalocrotonate tautomerase becomes an affinity label of its mutant  Academic Article
  • The proper connection between shelterin components is required for telomeric heterochromatin assembly  Academic Article
  • The protease activity of yeast separase (esp1) is required for anaphase spindle elongation independently of its role in cleavage of cohesin  Academic Article
  • The protein kinase cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast  Academic Article
  • The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance: a review  Academic Article
  • The rad50 signature motif: Essential to atp binding and biological function  Academic Article
  • The rad50 zinc-hook is a structure joining mre11 complexes in DNA recombination and repair  Academic Article
  • The receptor-binding and membrane-fusion properties of influenza-virus variants selected using anti-hemagglutinin monoclonal-antibodies  Academic Article
  • The red thread: oncogenes and their convergence in cancer research  Academic Article
  • The regulation of retina specific expression of rhodopsin gene in vertebrates  Academic Article
  • The retinoblastoma susceptibility gene-product regulates Myc-mediated transcription  Academic Article
  • The role of ARF1 and rab GTPases in polarization of the Golgi stack  Academic Article
  • The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins  Academic Article
  • The role of Drosophila mushroom body signaling in olfactory memory  Academic Article
  • The role of cytochrome-P-450 forms in 2-aminoanthracene and benz alpha pyrene mutagenesis  Academic Article
  • The role of prp in health and disease  Academic Article
  • The role of retroviral dutpases in replication and virulence  Academic Article
  • The roles of S1 RNA-binding domains in Rrp5's interactions with pre-rRNA  Academic Article
  • The search for Lps: 1993-1998  Academic Article
  • The selection of amber mutations in genes required for completion of start, the controlling event of the cell-division cycle of s-cerevisiae  Academic Article
  • The selection of s-cerevisiae mutants defective in the start event of cell-division  Academic Article
  • The self-inhibited structure of full-length PCSK9 at 1.9 Å reveals structural homology with resistin within the C-terminal domain  Academic Article
  • The serine protease tmprss6 is required to sense iron deficiency  Academic Article
  • The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle  Academic Article
  • The short-period mutant, toc1-1, alters circadian clock regulation of multiple outputs throughout development in Arabidopsis thaliana  Academic Article
  • The signal sequence of lymphocytic choriomeningitis virus contains an immunodominant cytotoxic t cell epitope that is restricted by both h-2d(b) and h-2k(b) molecules  Academic Article
  • The size-wise nucleus: nuclear volume control in eukaryotes  Academic Article
  • The structural basis of phenylketonuria  Academic Article
  • The structural basis of recognition and removal of cellular mrna 7-methyl g 'caps' by a viral capsid protein: A unique viral response to host defense  Academic Article
  • The structure of apo human glutamate dehydrogenase details subunit communication and allostery  Academic Article
  • The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0 Å resolution  Academic Article
  • The structure of pariacoto virus reveals a dodecahedral cage of duplex rna  Academic Article
  • The structure of the yeast nadh dehydrogenase (ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates  Academic Article
  • The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERR alpha)  Academic Article
  • The transition-state transcription regulator abrb of bacillus-subtilis is autoregulated during vegetative growth  Academic Article
  • The tropomodulin (Tmod) gene maps to chromosome 4, closely linked to Mup1  Academic Article
  • The ydaO motif is an ATP-sensing riboswitch in Bacillus subtilis  Academic Article
  • Therapeutic strategies to ameliorate lysosomal storage disorders - a focus on Gaucher disease  Academic Article
  • Three-dimensional structure of a recombinant gap junction membrane channel  Academic Article
  • Thrombosis in otherwise well children with the factor V leiden mutation  Academic Article
  • Thrombospondin-4 and its variants - expression and differential effects on endothelial cells  Academic Article
  • TiMEx: a waiting time model for mutually exclusive cancer alterations  Academic Article
  • Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor 1(2)tid, is critical for early embryonic development and cell survival  Academic Article
  • Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands  Academic Article
  • Tissue factor residue asp(44) regulates catalytic function of the bound proteinase factor vlla  Academic Article
  • Tissue factor residues lys(165) and lys(166) are essential for rapid formation of the quaternary complex of tissue-factor-center-dot-viia with xa-center-dot-tissue factor pathway inhibitor  Academic Article
  • Tissue-specific expressed antibody variable gene repertoires  Academic Article
  • Toll-like receptors: How they work and what they do  Academic Article
  • Tomato BRASSINOSTEROID INSENSITIVE1 is required for systemin-induced root elongation in Solanum pimpinellifolium but is not essential for wound signaling  Academic Article
  • Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance  Academic Article
  • Topoisomerase II suppresses the temperature sensitivity of Saccharomyces cerevisiae pds5 mutants, but not the defect in sister chromatid cohesion  Academic Article
  • TorsinA and torsion dystonia: unraveling the architecture of the nuclear envelope  Academic Article
  • Towards a comprehensive structural variation map of an individual human genome  Academic Article
  • Traffic pattern of cystic fibrosis transmembrane regulator through the early exocytic pathway  Academic Article
  • Trans-complementation rescue of cyclophilin A-deficient viruses reveals that the requirement for cyclophilin A in human immunodeficiency virus type 1 replication is independent of its isomerase activity  Academic Article
  • Trans-suppression of misfolding in an amyloid disease  Academic Article
  • Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus  Academic Article
  • Transcription factor HAT1 is phosphorylated by BIN2 kinase and mediates brassinosteroid repressed gene expression in Arabidopsis  Academic Article
  • Transcription of bacillus-subtilis subtilisin and expression of subtilisin in sporulation mutants  Academic Article
  • Transcriptional analysis of the caulobacter 4.5 s rna ffs gene and the physiological basis of an ffs mutant with a ts phenotype  Academic Article
  • Transcriptional and proteomic analysis of a ferric uptake regulator (fur) mutant of Shewanella oneidensis: possible involvement of fur in energy metabolism, transcriptional regulation, and oxidative stress  Academic Article
  • Transcriptional code and disease map for adult retinal cell types  Academic Article
  • Transfer of a prion strain to different hosts leads to emergence of strain variants  Academic Article
  • Transferrin-mediated targeting of bacteriophage hk97 nanoparticles into tumor cells  Academic Article
  • Transformation and insertional mutagenesis in vitro of primary hematopoietic stem cell cultures  Academic Article
  • Transgenerational epigenetic instability is a source of novel methylation variants  Academic Article
  • Translation of the chloroplast psbA mRNA requires the nuclear-encoded poly(A)-binding protein, RB47  Academic Article
  • Translational attenuation differentially alters the fate of disease-associated fibulin proteins  Academic Article
  • Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models  Academic Article
  • Transport and secretion of truncated t-cell receptor beta-chain occurs in the absence of association with cd3  Academic Article
  • Transthyretin Pro-36 associated with familial amyloidotic polyneuropathy in an Ashkenazic Jewish kindred  Academic Article
  • Transthyretin Pro55, a variant associated with early-onset, aggressive, diffuse amyloidosis with cardiac and neurologic involvement  Academic Article
  • Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity  Academic Article
  • Trif is not required for immune complex glomerulonephritis: Dying cells activate mesangial cells via tlr2/myd88 rather than tlr3/trif  Academic Article
  • Triple aminoacylation specificity of a chimerized transfer RNA  Academic Article
  • Trp-dependent auxin biosynthesis in Arabidopsis: involvement of cytochrome P450s CYP79B2 and CYP79B3  Academic Article
  • Ts transformation mutants of avian-sarcoma virus-prcii - lack of strict correlation between transforming ability and properties of the p105-associated kinase  Academic Article
  • Ts-pol mutants of avian-sarcoma viruses - mapping and demonstration of single cycle recombinants  Academic Article
  • Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition  Academic Article
  • Tumor regression by targeted gene delivery to the neovasculature  Academic Article
  • Tuning assembly size in peptide-based supramolecular polymers by modulation of subunit association affinity  Academic Article
  • Turning a protein kinase on or off from a single allosteric site via disulfide trapping  Academic Article
  • Two modes of protein sequence evolution and their compositional dependencies  Academic Article
  • Two murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genes  Academic Article
  • Two mutations in the dispensable part of alanine tRNA synthetase which affect the catalytic activity  Academic Article
  • Two novel SOD1 mutations in patients with familial amyotrophic lateral sclerosis  Academic Article
  • Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects  Academic Article
  • Two small c-type cytochromes affect virulence gene expression in bacillus anthracis  Academic Article
  • Two structural scenarios for protein stabilization by PEG  Academic Article
  • Two-dimensional IR spectroscopy of protein dynamics using two vibrational labels: a site-specific genetically encoded unnatural amino acid and an active site ligand  Academic Article
  • Type 5 G protein beta subunit (G beta 5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors  Academic Article
  • Type B response regulators act as central integrators in transcriptional control of the auxin biosynthesis enzyme TAA1  Academic Article
  • Tyrosine and serine phosphorylation regulate the conformation and subsequent threonine phosphorylation of the L1 cytoplasmic domain  Academic Article
  • Tyrosine cross-linking reveals interfacial dynamics in adeno-associated viral capsids during infection  Academic Article
  • Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase inhibitor  Academic Article
  • UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin  Academic Article
  • Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling  Academic Article
  • Ubiquitin facilitates a quality-control pathway that removes damaged chloroplasts  Academic Article
  • Ubiquitin ligase activity of tfiih and the transcriptional response to DNA damage  Academic Article
  • Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production  Academic Article
  • Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates  Academic Article
  • Ubiquitylation of cyclin e requires the sequential function of scf complexes containing distinct hcdc4 isoforms  Academic Article
  • Ultra-potent antibodies against respiratory syncytial virus: effects of binding kinetics and binding valence on viral neutralization  Academic Article
  • Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier  Academic Article
  • Ultrahigh and high resolution structures and mutational analysis of monomeric streptococcus pyogenes speb reveal a functional role for the glycine-rich c-terminal loop  Academic Article
  • Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection  Academic Article
  • Understanding the enzymatic activity of 4-oxalocrotonate tautomerase and its mutant analogues: A computational study  Academic Article
  • Unfolded proteins and protein folding studied by NMR  Academic Article
  • Unique domain appended to vertebrate tRNA synthetase is essential for vascular development  Academic Article
  • Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations  Academic Article
  • Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene  Academic Article
  • Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded rna occurs by trif-dependent and trif-independent pathways  Academic Article
  • Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in plasmodium falciparum  Academic Article
  • Use of silent mutations in cDNA encoding human glutathione transferase M2-2 for optimized expression in Escherichia coli  Academic Article
  • Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors  Academic Article
  • VH11 bias and normal V-D-J junctions in SCID B lymphocytes rescued by neonatal T cell transfer  Academic Article
  • VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses  Academic Article
  • Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention  Academic Article
  • Validation of isoleucine utilization targets in plasmodium falciparum  Academic Article
  • Variability of thrombosis among homozygous siblings with resistance to activated protein-C due to an Arg- Gln mutation in the gene for factor-V  Academic Article
  • Variable region sequences of murine igm anti-igg monoclonal autoantibodies (rheumatoid factors) - a structural explanation for the high-frequency of igm anti-igg b-cells  Academic Article
  • Vav and ras induce fibroblast transformation by overlapping signaling pathways, which require c-myc function  Academic Article
  • Velvet, a dominant egfr mutation that causes wavy hair and defective eyelid development in mice  Academic Article
  • Viral mutations, TCR antagonism and escape from the immune-response  Academic Article
  • Virus lymphocyte interactions .4. Molecular characterization of lcmv armstrong (ctl+) small genomic segment and that of its variant, clone-13 (ctl-)  Academic Article
  • Virus maturation targets the protein capsid to concerted disassembly and unfolding  Academic Article
  • Virus persistence and recurring demyelination produced by a temperature-sensitive mutant of mhv-4  Academic Article
  • Virus-induced immunosuppression - kinetic-analysis of the selection of a mutation associated with viral persistence  Academic Article
  • Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide  Academic Article
  • Whi5 regulation by site specific cdk-phosphorylation in saccharomyces cerevisiae  Academic Article
  • Whole-genome mutational burden analysis of three pluripotency induction methods  Academic Article
  • Whole-genome sequencing and microarray analysis of ex vivo plasmodium vivax reveal selective pressure on putative drug resistance genes  Academic Article
  • X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C  Academic Article
  • Xenobiotic metabolism and mutation in a human lymphoblastoid cell line  Academic Article
  • Xpd helicase structures and activities: Insights into the cancer and aging phenotypes from xpd mutations  Academic Article
  • Yeast LEU5 is a PET-like gene that is not essential for leucine biosynthesis  Academic Article
  • Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice  Academic Article
  • ZBTB1 is a determinant of lymphoid development  Academic Article
  • Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates. A mini-review  Academic Article
  • hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene  Academic Article
  • hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function  Academic Article
  • kurtz, a novel nonvisual arrestin, is an essential neural gene in Drosophila  Academic Article
  • l(3)malignant brain tumor and three novel genes are required for Drosophila germ-cell formation  Academic Article
  • roX1 RNA paints the X chromosome of male Drosophila and is regulated by the dosage compensation system  Academic Article
  • tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the Arabidopsis circadian oscillator  Academic Article
  • β-hairpin-mediated nucleation of polyglutamine amyloid formation  Academic Article

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