subject area of
- "Resistance" to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 do not confer resistance Academic Article
- 'Late onset' ornithine transcarbamylase deficiency: function of three purified recombinant mutant enzymes Academic Article
- 3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting Academic Article
- 5' cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved 5' GU Academic Article
- A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2 Academic Article
- A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon Academic Article
- A CCHC metal-binding domain in Nanos is essential for translational regulation Academic Article
- A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response Academic Article
- A Saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability Academic Article
- A THEMIS:SHP1 complex promotes T-cell survival Academic Article
- A bacterial amber suppressor in Saccharomyces cerevisiae is selectively recognized by a bacterial aminoacyl-tRNA synthetase Academic Article
- A base change in the catalytic core of the hairpin ribozyme perturbs function but not domain docking Academic Article
- A base triple in the tetrahymena group i core affects the reaction equilibrium via a threshold effect Academic Article
- A c-alpha model for the transmembrane alpha helices of gap junction intercellular channels Academic Article
- A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Academic Article
- A cell cycle phosphoproteome of the yeast centrosome Academic Article
- A cell-autonomous requirement for the cell cycle regulatory protein, rb, in neuronal migration Academic Article
- A cell-cycle checkpoint monitors cell morphogenesis in budding yeast Academic Article
- A chemical chaperone decouples TDP-43 disordered domain phase separation from fibrillation Academic Article
- A chemical toolkit for proteins: an expanded genetic code Academic Article
- A chiroselective peptide replicator Academic Article
- A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease Academic Article
- A clonal analysis of tergite development in Drosophila of ultraabdominal and paradoxical genotypes Academic Article
- A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells Academic Article
- A conservative isoleucine to leucine mutation causes major rearrangements and cold sensitivity in KlenTaq1 DNA polymerase Academic Article
- A conserved family of prolyl-4-hydroxylases that modify HIF Academic Article
- A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins Academic Article
- A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension Academic Article
- A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function Academic Article
- A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development Academic Article
- A covering method for detecting genetic associations between rare variants and common phenotypes Academic Article
- A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells Academic Article
- A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics Academic Article
- A crucial role for the putative Arabidopsis topoisomerase VI in plant growth and development Academic Article
- A de novo designed peptide ligase: A mechanistic investigation Academic Article
- A de novo protein binding pair by computational design and directed evolution Academic Article
- A designed inhibitor of a CLC antiporter blocks function through a unique binding mode Academic Article
- A di-acidic (DxE) code directs concentration of cargo during export from the endoplasmic reticulum Academic Article
- A di-acidic signal required for selective export from the endoplasmic reticulum Academic Article
- A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase Academic Article
- A distinct set of drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory Academic Article
- A dominant negative mutant of the E. Coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit Academic Article
- A dominant-negative peroxisome proliferator-activated receptor gamma (ppar gamma) mutant is a constitutive repressor and inhibits ppar gamma-mediated adipogenesis Academic Article
- A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory Academic Article
- A dynamin mutant defines a superconstricted prefission state Academic Article
- A family of cyclin homologs that control the g1 phase in yeast Academic Article
- A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity Academic Article
- A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function Academic Article
- A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity Academic Article
- A general method for greatly improving the affinity of antibodies by using combinatorial libraries Academic Article
- A general method for site-specific incorporation of unnatural amino acids into proteins Academic Article
- A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers Academic Article
- A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase Academic Article
- A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe Academic Article
- A glutamate switch controls voltage-sensitive phosphatase function Academic Article
- A growth regulatory loop that provides homeostasis to phytochrome A signaling Academic Article
- A guanosine to adenosine transition in the 3' terminal extracistronic region of bacteriophage Qβ RNA leading to loss of infectivity Academic Article
- A helix replacement mechanism directs metavinculin functions Academic Article
- A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B Academic Article
- A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion Academic Article
- A highly conserved neutralizing epitope on group 2 influenza a viruses Academic Article
- A highly membrane-active peptide in Flock House virus: Implications for the mechanism of nodavirus infection Academic Article
- A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1 Academic Article
- A human germ line antibody light chain with hydrolytic properties associated with multimerization status Academic Article
- A humanized anti-4-1bb monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates Academic Article
- A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd Academic Article
- A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses Academic Article
- A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41 Academic Article
- A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa Academic Article
- A membrane-embedded amino acid couples the SpoIIQ channel protein to anti-sigma factor transcriptional repression during Bacillus subtilis sporulation Academic Article
- A metal-binding motif implicated in RNA recognition by an aminoacyl-tRNA synthetase and by a retroviral gene product Academic Article
- A method to site-specifically introduce methyllysine into proteins in E. coli Academic Article
- A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron Academic Article
- A missense mutation in the neutrophil cytochrome-b heavy-chain in cytochrome-positive x-linked chronic granulomatous-disease Academic Article
- A molecular description of the evolution of resistance Academic Article
- A molecular switch regulating transcriptional repression and activation of PPARγ Academic Article
- A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration Academic Article
- A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks Academic Article
- A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response Academic Article
- A mutant of rous sarcoma virus (type o) causing fusiform cell transformation Academic Article
- A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function Academic Article
- A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome Academic Article
- A mutation in the FHA domain of Coprinus cinereus Nbs1 leads to Spo11-independent meiotic recombination and chromosome segregation Academic Article
- A mutation in the human cyclin-dependent kinase interacting protein, ckshs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly Academic Article
- A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters Academic Article
- A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα Academic Article
- A new regulatory switch in a JAK protein kinase Academic Article
- A new strategy for the synthesis of glycoproteins Academic Article
- A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis Academic Article
- A note on efficient estimation of mutation-rates using luria-delbruck fluctuation analysis Academic Article
- A novel GJA8 mutation (p.V44A) causing autosomal dominant congenital cataract Academic Article
- A novel cross-talk in diacylglycerol signaling the rac-gap beta 2-chimaerin is negatively regulated by protein kinase c delta-mediated phosphorylation Academic Article
- A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex Academic Article
- A novel promoter motif for caulobacter cell cycle-controlled DNA replication genes Academic Article
- A novel splice acceptor site mutation which produces multiple splicing abnormalities resulting in protein S deficiency type I Academic Article
- A novel technique for the rapid preparation of mutant RNAs Academic Article
- A nucleoside transporter from Trypanosoma brucei involved in drug resistance Academic Article
- A p47-phox pseudogene carries the most common mutation causing p47-phox-deficient chronic granulomatous disease Academic Article
- A perspective on the structural and functional constraints for immune evasion: insights from influenza virus Academic Article
- A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins Academic Article
- A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor Academic Article
- A plasma membrane H(+)-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana Academic Article
- A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Academic Article
- A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins Academic Article
- A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.Fem-3 mRNA complex Academic Article
- A putative bacterial ABC transporter circumvents the essentiality of signal peptidase Academic Article
- A quick diversity-oriented amide-forming reaction to optimize p-subsite residues of hiv protease inhibitors Academic Article
- A rab1 mutant affecting guanine-nucleotide exchange promotes disassembly of the golgi-apparatus Academic Article
- A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin Academic Article
- A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90 Academic Article
- A role for brassinosteroids in light-dependent development of Arabidopsis Academic Article
- A role for dual viral hits in causation of subacute sclerosing panencephalitis Academic Article
- A role for flavin monooxygenase-like enzymes in auxin biosynthesis Academic Article
- A role for peroxisomes in photomorphogenesis and development of Arabidopsis Academic Article
- A role for the P-body component GW182 in microRNA function Academic Article
- A role for the swe1 checkpoint kinase during filamentous growth of saccharomyces cerevisiae Academic Article
- A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib Academic Article
- A role of the kinase mtor in cellular transformation induced by the oncoproteins p3k and akt Academic Article
- A selective chemical probe for coenzyme a - requiring enzymes Academic Article
- A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo Academic Article
- A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth Academic Article
- A siglec-like sialic-acid-binding motif revealed in an adenovirus capsid protein Academic Article
- A silencer element in the retinoblastoma tumor-suppressor gene Academic Article
- A simple structural feature is a major determinant of the identity of a transfer RNA Academic Article
- A single amino-acid change in the mouse peroxisome proliferator-activated receptor-alpha alters transcriptional responses to peroxisome proliferators Academic Article
- A single base pair affects binding and catalytic parameters in the molecular recognition of a transfer RNA Academic Article
- A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression Academic Article
- A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouse Academic Article
- A sphingosine 1-phosphate receptor 2 selective allosteric agonist Academic Article
- A structural view of evolutionary divergence Academic Article
- A study of genes that may modulate the expression of hereditary hemochromatosis: Transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (irp)-1 and-2, and hepcidin Academic Article
- A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase Academic Article
- A temperature-sensitive lesion affecting levels of transformation-specific viral RNA in a mutant of avian sarcoma virus PRCII Academic Article
- A transcriptional repressor obtained by alternative translation of a trinucleotide repeat Academic Article
- A two-component signal transduction system essential for growth of bacillus subtilis: Implications for anti-infective therapy Academic Article
- A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5 Academic Article
- A unique gtp-dependent sporulation sensor histidine kinase in bacillus anthracis Academic Article
- A virus-based nanoblock with tunable electrostatic properties Academic Article
- ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair Academic Article
- ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC Academic Article
- AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin Academic Article
- ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization Academic Article
- ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import Academic Article
- ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1 Academic Article
- Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine Academic Article
- Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells Academic Article
- Accessory mutations maintain stability in drug-resistant HIV-1 protease Academic Article
- Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae Academic Article
- Acidic food pH increases palatability and consumption and extends drosophila lifespan Academic Article
- Acidification of endosome subpopulations in wild-type chinese-hamster ovary cells and temperature-sensitive acidification-defective mutants Academic Article
- Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering Academic Article
- Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions Academic Article
- Activated protein C resistance caused by Arg506Gln mutation in factor Va Academic Article
- Activated protein C variants with normal cytoprotective but reduced anticoagulant activity Academic Article
- Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe Academic Article
- Activation domain-dependent monoubiquitylation of Gal4 protein is essential for promoter binding in vivo Academic Article
- Activation of snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos Academic Article
- Activation of tumor cell integrin alpha(v)beta(3) controls angiogenesis and metastatic growth in the brain Academic Article
- Activation tagging of the floral inducer FT Academic Article
- Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast Academic Article
- Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein Academic Article
- Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties Academic Article
- Active site residues of cyclophilin A are crucial for its signaling activity via CD147 Academic Article
- Active site serine promotes stabilization of the reactive glutathione thiolate in rat glutathione transferase T2-2 - Evidence against proposed sulfatase activity of the corresponding human enzyme Academic Article
- Active, interactive, and inactive steroid-receptor mutants Academic Article
- Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3 Academic Article
- Activity of yeast extracts in cell-free stimulation of DNA-replication Academic Article
- Activity-guided engineering of natural product carrier proteins Academic Article
- Adaptive mutations alter antibody structure and dynamics during affinity maturation Academic Article
- Adenovirus core protein pvii is translocated into the nucleus by multiple import receptor pathways Academic Article
- Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by rho family gtpases Academic Article
- Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice Academic Article
- Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie b-adenovirus receptor-bearing cells Academic Article
- Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae Academic Article
- Adult chicken alpha-globin gene-expression in transfected qt6 quail cells - evidence for a negative regulatory element in the alpha-d gene region Academic Article
- Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling Academic Article
- Age-related somatic structural changes in the nuclear genome of human blood cells Academic Article
- Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes Academic Article
- Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA Academic Article
- All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase Academic Article
- Alloreactive T cells discriminate among a diverse set of endogenous peptides Academic Article
- Alteration of bacillus-subtilis glutamine-synthetase results in overproduction of enzyme Academic Article
- Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant Academic Article
- Alteration of the reduction potential of the 4fe-4s (2+/+) cluster of azotobacter vinelandii ferredoxin i Academic Article
- Alteration of the α-synuclein folding landscape by a mutation related to Parkinson's disease Academic Article
- Alterations in the flow of one-carbon units affect kinb-dependent sporulation in bacillus subtilis Academic Article
- Altered chaperone-like activity of α-crystallins promotes cataractogenesis Academic Article
- Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system Academic Article
- Altered mRNA binding activity and decreased translation initiation in a nuclear mutant lacking translation of the chloroplast psbA mRNA Academic Article
- Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery Academic Article
- Alternative mutations of a positively selected residue elicit qain or loss of functionalities in enzyme evolution Academic Article
- Alternative outcomes in assembly of promoter complexes: The roles of TBP and a flexible linker in placing TFIIIB on tRNA genes Academic Article
- Alternative splicing within the ligand binding domain of the human constitutive androstane receptor Academic Article
- Alzheimer's Aβ peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)? Academic Article
- American College of Medical Genetics consensus statement on factor V Leiden mutation testing Academic Article
- Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase Academic Article
- Amino acid substitution at the dimeric interface of human manganese superoxide dismutase Academic Article
- Amino-acid replacements that compensate for a large polypeptide deletion in an enzyme Academic Article
- Aminoacyl tRNA synthetases and their connections to disease Academic Article
- Aminoacyl-tRNA synthetases: general features and recognition of transfer RNAs Academic Article
- Amplification, mutation and selection of catalytic RNA Academic Article
- Amplification, rearrangement, and elevated expression of c-myc in the human prostatic carcinoma cell line LNCaP Academic Article
- Amyloid diseases: Abnormal protein aggregation in neurodegeneration Academic Article
- Amyotrophic Lateral Sclerosis Academic Article
- Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase Academic Article
- An Arabidopsis mutant defective in the plastid general protein import apparatus Academic Article
- An Arabidopsis thaliana virescent mutant reveals a role for ClpR1 in plastid development Academic Article
- An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence Academic Article
- An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors Academic Article
- An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide Academic Article
- An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway Academic Article
- An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model Academic Article
- An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening Academic Article
- An association of candidate gene haplotypes and bleeding severity in von willebrand disease type 2a, 2b, and 2m pedigrees Academic Article
- An engineered virus as a scaffold for three-dimensional self-assembly on the nanoscale Academic Article
- An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes Academic Article
- An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses Academic Article
- An essential GTpase promotes assembly of preribosomal RNA processing complexes Academic Article
- An essential g1 function for cyclin-like proteins in yeast Academic Article
- An expanded eukaryotic genetic code Academic Article
- An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system Academic Article
- An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae Academic Article
- An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5 Academic Article
- An intact conformation at the tip of elongation factor G domain IV is functionally important Academic Article
- An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity Academic Article
- An interchromosomal gene conversion of the Drosophila dunce locus identified with restriction site polymorphisms: a potential involvement of transposable elements in gene conversion Academic Article
- An intracellular signal transduction pathway between the chloroplast and nucleus is involved in de-etiolation Academic Article
- An isogenic human ESC platform for functional evaluation of genome-wide-association-study-identified diabetes genes and drug discovery Academic Article
- An mrna-rrna base-pairing mechanism for translation initiation in eukaryotes Academic Article
- An online resource for GPCR structure determination and analysis Academic Article
- An orthogonal DNA replication system in yeast Academic Article
- An unexpected outcome of surface engineering an integral membrane protein: Improved crystallization of cytochrome ba(3) from thermus thermophilus Academic Article
- Analysis by electron-microscopy of early simian-virus 40 rna from a tsa mutant Academic Article
- Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries Academic Article
- Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor Academic Article
- Analysis of individual immunoglobulin-lambda light-chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center b-cell somatic mutation Academic Article
- Analysis of male pheromones that accelerate female reproductive organ development Academic Article
- Analysis of novel residues of class I involved in recognition by alloreactive T cells Academic Article
- Analysis of rrna processing and translation in mammalian cells using a synthetic 18s rrna expression system Academic Article
- Analysis of stop-gain and frameshift variants in human innate immunity genes Academic Article
- Analyzing and tuning ribozyme activity by deep sequencing to modulate gene expression level in mammalian cells Academic Article
- Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase Academic Article
- Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity Academic Article
- Antibodies against small nuclear ribonucleoproteins immunoprecipitate complexes containing ts110 Moloney murine sarcoma virus genomic and messenger RNAs Academic Article
- Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics Academic Article
- Antigen presentation and t cell development in h2-m-deficient mice Academic Article
- Antigen-driven B cell differentiation in vivo Academic Article
- Antigenic analyses of influenza-virus hemagglutinins with different receptor-binding specificities Academic Article
- Antisense masking reveals contributions of mrna- rrna base pairing to translation of gtx and fgf2 mrnas Academic Article
- Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors Academic Article
- Application of site-directed mutagenesis to rna and DNA genomes Academic Article
- Approaches for skeletal gene therapy Academic Article
- Arabidopsis MYB30 is a direct target of BES1 and cooperates with BES1 to regulate brassinosteroid-induced gene expression Academic Article
- Arabidopsis thaliana mutant that develops as a light-grown plant in the absence of light Academic Article
- Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation Academic Article
- Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors Academic Article
- Architecture of the flagellar rotor Academic Article
- Arenavirus diversity and evolution: Quasispecies in vivo Academic Article
- Arenavirus extinction through lethal mutagenesis Academic Article
- Aromatic residues in the C-terminal region of glutathione transferase A1-1 influence rate-determining steps in the catalytic mechanism Academic Article
- Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein Academic Article
- Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase Academic Article
- Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility Academic Article
- Assembly of the covalent linkage between lipoic acid and its cognate enzymes Academic Article
- Assignment of the L30-mRNA complex using selective isotopic labeling and RNA mutants Academic Article
- Association between a disrupted-in-schizophrenia 1 (disc1) single nucleotide polymorphism and schizophrenia in a combined scandinavian case-control sample Academic Article
- Association between thromboembolic events and the JAK2 V617F mutation in myeloproliferative neoplasms Academic Article
- Association of the 2-mu-m DNA plasmid with yeast folded chromosomes Academic Article
- Associations between phylogenetic clustering and HLA profile among HIV-infected individuals in San Diego, California Academic Article
- Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificities Academic Article
- Atl1 regulates choice between global genome and transcription-coupled repair of o-6-alkylguanines Academic Article
- Atomic accuracy in predicting and designing noncanonical RNA structure Academic Article
- Atomic structures of wild-type and thermostable mutant recombinant human cu,zn superoxide-dismutase Academic Article
- Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex Academic Article
- Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface Academic Article
- Autoantibodies as reporters identifying aberrant cellular mechanisms in tumorigenesis Academic Article
- Automated analysis of hypocotyl growth dynamics during shade avoidance in Arabidopsis Academic Article
- Automated identification of functional dynamic contact networks from X-ray crystallography Academic Article
- Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity Academic Article
- Autoproteolysis in nucleoporin biogenesis Academic Article
- Autoregulation of simian virus-40 gene-a by t-antigen Academic Article
- Avian-sarcoma virus mutant that is temperature sensitive for virion assembly Academic Article
- Avian-sarcoma virus prcii - conditional mutants temperature sensitive in the maintenance of fibroblast transformation Academic Article
- Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential Academic Article
- BACE1- and BACE2-expressing human cells - characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors Academic Article
- BAS1: A gene regulating brassinosteroid levels and light responsiveness in Arabidopsis Academic Article
- BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice Academic Article
- BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation Academic Article
- BIG: a calossin-like protein required for polar auxin transport in Arabidopsis Academic Article
- BIN2, a new brassinosteroid-insensitive locus in Arabidopsis Academic Article
- BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis Academic Article
- BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis Academic Article
- BRANCHED1 interacts with FLOWERING LOCUS T to repress the floral transition of the axillary meristems in Arabidopsis Academic Article
- BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint Academic Article
- BRI1 is a critical component of a plasma-membrane receptor for plant steroids Academic Article
- BRL1 and BRL3 are novel brassinosteroid receptors that function in vascular differentiation in Arabidopsis Academic Article
- Bacillus subtilis chec and fliy are members of a novel class of chey-p-hydrolyzing proteins in the chemotactic signal transduction cascade Academic Article
- Backbone-backbone H-bonds make context-dependent contributions to protein folding kinetics and thermodynamics: lessons from amide-to-ester mutations Academic Article
- Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin Academic Article
- Balanced electrostatic and structural forces guide the large conformational change associated with maturation of t=4 virus Academic Article
- Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA Academic Article
- Base pairing between hepatitis C virus RNA and 18S rRNA is required for IRES-dependent translation initiation in vivo Academic Article
- Bcl-2 is an apoptotic target suppressed by both c-myc and e2f-1 Academic Article
- Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis Academic Article
- Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3 Academic Article
- Beware of multiple comparisons: A study of symptoms associated with mutations of the hfe hemochromatosis gene Academic Article
- Biallelic mutations in IRF8 impair human NK cell maturation and function Academic Article
- Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease Academic Article
- Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome p450 46a1 unusual features and spectral response Academic Article
- Binding of neural cell adhesion molecules (n-cams) to the cellular prion protein Academic Article
- Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity Academic Article
- Biobanking: an important resource for precision medicine in glioblastoma Academic Article
- Biochemical characterization and crystal structure of a dim1 family associated protein: Dim2 Academic Article
- Biochemical characterization of Arabidopsis wild-type and mutant phytochrome B holoproteins Academic Article
- Biochemical characterization of the Caenorhabditis elegans FBF. CPB-1 translational regulation complex identifies conserved protein interaction hotspots Academic Article
- Biochemical characterization of the tata-binding protein-gal4 activation domain complex Academic Article
- Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1 Academic Article
- Biochemical-characterization of the essential gtp-binding protein obg of bacillus-subtilis Academic Article
- Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis Academic Article
- Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants Academic Article
- Biomarkers of endocannabinoid system activation in severe obesity Academic Article
- Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes Academic Article
- Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors Academic Article
- Biosynthesis of the enediyne antitumor antibiotic c-1027 Academic Article
- Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants Academic Article
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