Mutation

subject area of

"Resistance" to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 do not confer resistance Academic Article
'Late onset' ornithine transcarbamylase deficiency: function of three purified recombinant mutant enzymes Academic Article
3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting Academic Article
5' cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved 5' GU Academic Article
A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2 Academic Article
A Bifluorescent-Based Assay for the Identification of Neutralizing Antibodies against SARS-CoV-2 Variants of Concern In Vitro and In Vivo Academic Article
A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon Academic Article
A CCHC metal-binding domain in Nanos is essential for translational regulation Academic Article
A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response Academic Article
A Saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability Academic Article
A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome Academic Article
A THEMIS:SHP1 complex promotes T-cell survival Academic Article
A bacterial amber suppressor in Saccharomyces cerevisiae is selectively recognized by a bacterial aminoacyl-tRNA synthetase Academic Article
A base change in the catalytic core of the hairpin ribozyme perturbs function but not domain docking Academic Article
A base triple in the tetrahymena group i core affects the reaction equilibrium via a threshold effect Academic Article
A c-alpha model for the transmembrane alpha helices of gap junction intercellular channels Academic Article
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Academic Article
A cell cycle phosphoproteome of the yeast centrosome Academic Article
A cell-autonomous requirement for the cell cycle regulatory protein, rb, in neuronal migration Academic Article
A cell-cycle checkpoint monitors cell morphogenesis in budding yeast Academic Article
A chemical chaperone decouples TDP-43 disordered domain phase separation from fibrillation Academic Article
A chemical toolkit for proteins: an expanded genetic code Academic Article
A chiroselective peptide replicator Academic Article
A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease Academic Article
A clonal analysis of tergite development in Drosophila of ultraabdominal and paradoxical genotypes Academic Article
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells Academic Article
A conservative isoleucine to leucine mutation causes major rearrangements and cold sensitivity in KlenTaq1 DNA polymerase Academic Article
A conserved family of prolyl-4-hydroxylases that modify HIF Academic Article
A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins Academic Article
A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension Academic Article
A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function Academic Article
A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development Academic Article
A covering method for detecting genetic associations between rare variants and common phenotypes Academic Article
A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells Academic Article
A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics Academic Article
A crucial role for the putative Arabidopsis topoisomerase VI in plant growth and development Academic Article
A de novo designed peptide ligase: A mechanistic investigation Academic Article
A de novo protein binding pair by computational design and directed evolution Academic Article
A designed inhibitor of a CLC antiporter blocks function through a unique binding mode Academic Article
A di-acidic (DxE) code directs concentration of cargo during export from the endoplasmic reticulum Academic Article
A di-acidic signal required for selective export from the endoplasmic reticulum Academic Article
A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase Academic Article
A distinct set of drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory Academic Article
A dominant negative mutant of the E. Coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit Academic Article
A dominant-negative peroxisome proliferator-activated receptor gamma (ppar gamma) mutant is a constitutive repressor and inhibits ppar gamma-mediated adipogenesis Academic Article
A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory Academic Article
A dynamin mutant defines a superconstricted prefission state Academic Article
A family of cyclin homologs that control the g1 phase in yeast Academic Article
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity Academic Article
A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function Academic Article
A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity Academic Article
A general method for greatly improving the affinity of antibodies by using combinatorial libraries Academic Article
A general method for site-specific incorporation of unnatural amino acids into proteins Academic Article
A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers Academic Article
A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase Academic Article
A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe Academic Article
A glutamate switch controls voltage-sensitive phosphatase function Academic Article
A growth regulatory loop that provides homeostasis to phytochrome A signaling Academic Article
A guanosine to adenosine transition in the 3' terminal extracistronic region of bacteriophage Qβ RNA leading to loss of infectivity Academic Article
A helix replacement mechanism directs metavinculin functions Academic Article
A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B Academic Article
A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion Academic Article
A highly conserved neutralizing epitope on group 2 influenza a viruses Academic Article
A highly membrane-active peptide in Flock House virus: Implications for the mechanism of nodavirus infection Academic Article
A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1 Academic Article
A human germ line antibody light chain with hydrolytic properties associated with multimerization status Academic Article
A humanized anti-4-1bb monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates Academic Article
A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd Academic Article
A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses Academic Article
A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41 Academic Article
A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa Academic Article
A membrane-embedded amino acid couples the SpoIIQ channel protein to anti-sigma factor transcriptional repression during Bacillus subtilis sporulation Academic Article
A metal-binding motif implicated in RNA recognition by an aminoacyl-tRNA synthetase and by a retroviral gene product Academic Article
A metastasis map of human cancer cell lines Academic Article
A method to site-specifically introduce methyllysine into proteins in E. coli Academic Article
A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron Academic Article
A missense mutation in the neutrophil cytochrome-b heavy-chain in cytochrome-positive x-linked chronic granulomatous-disease Academic Article
A molecular description of the evolution of resistance Academic Article
A molecular switch regulating transcriptional repression and activation of PPARγ Academic Article
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration Academic Article
A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks Academic Article
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response Academic Article
A mutant of rous sarcoma virus (type o) causing fusiform cell transformation Academic Article
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function Academic Article
A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome Academic Article
A mutation in the FHA domain of Coprinus cinereus Nbs1 leads to Spo11-independent meiotic recombination and chromosome segregation Academic Article
A mutation in the human cyclin-dependent kinase interacting protein, ckshs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly Academic Article
A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters Academic Article
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα Academic Article
A natural variant and engineered mutation in a GPCR promote DEET resistance in C-elegans Academic Article
A new regulatory switch in a JAK protein kinase Academic Article
A new strategy for the synthesis of glycoproteins Academic Article
A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis Academic Article
A note on efficient estimation of mutation-rates using luria-delbruck fluctuation analysis Academic Article
A novel GJA8 mutation (p.V44A) causing autosomal dominant congenital cataract Academic Article
A novel cross-talk in diacylglycerol signaling the rac-gap beta 2-chimaerin is negatively regulated by protein kinase c delta-mediated phosphorylation Academic Article
A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex Academic Article
A novel promoter motif for caulobacter cell cycle-controlled DNA replication genes Academic Article
A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores Academic Article
A novel splice acceptor site mutation which produces multiple splicing abnormalities resulting in protein S deficiency type I Academic Article
A novel technique for the rapid preparation of mutant RNAs Academic Article
A nucleoside transporter from Trypanosoma brucei involved in drug resistance Academic Article
A p47-phox pseudogene carries the most common mutation causing p47-phox-deficient chronic granulomatous disease Academic Article
A perspective on the structural and functional constraints for immune evasion: insights from influenza virus Academic Article
A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins Academic Article
A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor Academic Article
A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding Academic Article
A plasma membrane H(+)-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana Academic Article
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Academic Article
A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins Academic Article
A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.Fem-3 mRNA complex Academic Article
A putative bacterial ABC transporter circumvents the essentiality of signal peptidase Academic Article
A quick diversity-oriented amide-forming reaction to optimize p-subsite residues of hiv protease inhibitors Academic Article
A rab1 mutant affecting guanine-nucleotide exchange promotes disassembly of the golgi-apparatus Academic Article
A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin Academic Article
A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90 Academic Article
A role for brassinosteroids in light-dependent development of Arabidopsis Academic Article
A role for dual viral hits in causation of subacute sclerosing panencephalitis Academic Article
A role for flavin monooxygenase-like enzymes in auxin biosynthesis Academic Article
A role for peroxisomes in photomorphogenesis and development of Arabidopsis Academic Article
A role for the P-body component GW182 in microRNA function Academic Article
A role for the swe1 checkpoint kinase during filamentous growth of saccharomyces cerevisiae Academic Article
A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib Academic Article
A role of the kinase mtor in cellular transformation induced by the oncoproteins p3k and akt Academic Article
A selective chemical probe for coenzyme a - requiring enzymes Academic Article
A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo Academic Article
A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth Academic Article
A siglec-like sialic-acid-binding motif revealed in an adenovirus capsid protein Academic Article
A silencer element in the retinoblastoma tumor-suppressor gene Academic Article
A simple structural feature is a major determinant of the identity of a transfer RNA Academic Article
A single amino-acid change in the mouse peroxisome proliferator-activated receptor-alpha alters transcriptional responses to peroxisome proliferators Academic Article
A single base pair affects binding and catalytic parameters in the molecular recognition of a transfer RNA Academic Article
A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression Academic Article
A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouse Academic Article
A sphingosine 1-phosphate receptor 2 selective allosteric agonist Academic Article
A structural view of evolutionary divergence Academic Article
A study of genes that may modulate the expression of hereditary hemochromatosis: Transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (irp)-1 and-2, and hepcidin Academic Article
A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase Academic Article
A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations Academic Article
A temperature-sensitive lesion affecting levels of transformation-specific viral RNA in a mutant of avian sarcoma virus PRCII Academic Article
A transcriptional repressor obtained by alternative translation of a trinucleotide repeat Academic Article
A two-component signal transduction system essential for growth of bacillus subtilis: Implications for anti-infective therapy Academic Article
A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5 Academic Article
A unique gtp-dependent sporulation sensor histidine kinase in bacillus anthracis Academic Article
A virus-based nanoblock with tunable electrostatic properties Academic Article
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair Academic Article
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC Academic Article
AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin Academic Article
ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization Academic Article
ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import Academic Article
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1 Academic Article
Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine Academic Article
Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells Academic Article
Accessory mutations maintain stability in drug-resistant HIV-1 protease Academic Article
Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae Academic Article
Acidic food pH increases palatability and consumption and extends drosophila lifespan Academic Article
Acidification of endosome subpopulations in wild-type chinese-hamster ovary cells and temperature-sensitive acidification-defective mutants Academic Article
Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering Academic Article
Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations Academic Article
Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions Academic Article
Activated protein C resistance caused by Arg506Gln mutation in factor Va Academic Article
Activated protein C variants with normal cytoprotective but reduced anticoagulant activity Academic Article
Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe Academic Article
Activation domain-dependent monoubiquitylation of Gal4 protein is essential for promoter binding in vivo Academic Article
Activation of snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos Academic Article
Activation of tumor cell integrin alpha(v)beta(3) controls angiogenesis and metastatic growth in the brain Academic Article
Activation tagging of the floral inducer FT Academic Article
Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast Academic Article
Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein Academic Article
Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties Academic Article
Active site residues of cyclophilin A are crucial for its signaling activity via CD147 Academic Article
Active site serine promotes stabilization of the reactive glutathione thiolate in rat glutathione transferase T2-2 - Evidence against proposed sulfatase activity of the corresponding human enzyme Academic Article
Active, interactive, and inactive steroid-receptor mutants Academic Article
Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3 Academic Article
Activity of yeast extracts in cell-free stimulation of DNA-replication Academic Article
Activity-guided engineering of natural product carrier proteins Academic Article
Adaptive mutations alter antibody structure and dynamics during affinity maturation Academic Article
Adenovirus core protein pvii is translocated into the nucleus by multiple import receptor pathways Academic Article
Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by rho family gtpases Academic Article
Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice Academic Article
Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie b-adenovirus receptor-bearing cells Academic Article
Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae Academic Article
Adult chicken alpha-globin gene-expression in transfected qt6 quail cells - evidence for a negative regulatory element in the alpha-d gene region Academic Article
Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling Academic Article
Age-related somatic structural changes in the nuclear genome of human blood cells Academic Article
Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes Academic Article
Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA Academic Article
All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase Academic Article
Alloreactive T cells discriminate among a diverse set of endogenous peptides Academic Article
Alteration of bacillus-subtilis glutamine-synthetase results in overproduction of enzyme Academic Article
Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant Academic Article
Alteration of the reduction potential of the 4fe-4s (2+/+) cluster of azotobacter vinelandii ferredoxin i Academic Article
Alteration of the α-synuclein folding landscape by a mutation related to Parkinson's disease Academic Article
Alterations in the flow of one-carbon units affect kinb-dependent sporulation in bacillus subtilis Academic Article
Altered chaperone-like activity of α-crystallins promotes cataractogenesis Academic Article
Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system Academic Article
Altered mRNA binding activity and decreased translation initiation in a nuclear mutant lacking translation of the chloroplast psbA mRNA Academic Article
Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery Academic Article
Alternative mutations of a positively selected residue elicit qain or loss of functionalities in enzyme evolution Academic Article
Alternative outcomes in assembly of promoter complexes: The roles of TBP and a flexible linker in placing TFIIIB on tRNA genes Academic Article
Alternative splicing within the ligand binding domain of the human constitutive androstane receptor Academic Article
Alzheimer's Aβ peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)? Academic Article
American College of Medical Genetics consensus statement on factor V Leiden mutation testing Academic Article
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase Academic Article
Amino acid substitution at the dimeric interface of human manganese superoxide dismutase Academic Article
Amino-acid replacements that compensate for a large polypeptide deletion in an enzyme Academic Article
Aminoacyl tRNA synthetases and their connections to disease Academic Article
Aminoacyl-tRNA synthetases: general features and recognition of transfer RNAs Academic Article
Amplification, mutation and selection of catalytic RNA Academic Article
Amplification, rearrangement, and elevated expression of c-myc in the human prostatic carcinoma cell line LNCaP Academic Article
Amyloid diseases: Abnormal protein aggregation in neurodegeneration Academic Article
Amyotrophic Lateral Sclerosis Academic Article
Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase Academic Article
An Arabidopsis mutant defective in the plastid general protein import apparatus Academic Article
An Arabidopsis thaliana virescent mutant reveals a role for ClpR1 in plastid development Academic Article
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence Academic Article
An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors Academic Article
An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide Academic Article
An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway Academic Article
An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model Academic Article
An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening Academic Article
An association of candidate gene haplotypes and bleeding severity in von willebrand disease type 2a, 2b, and 2m pedigrees Academic Article
An engineered virus as a scaffold for three-dimensional self-assembly on the nanoscale Academic Article
An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes Academic Article
An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses Academic Article
An essential GTpase promotes assembly of preribosomal RNA processing complexes Academic Article
An essential g1 function for cyclin-like proteins in yeast Academic Article
An expanded eukaryotic genetic code Academic Article
An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system Academic Article
An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae Academic Article
An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5 Academic Article
An intact conformation at the tip of elongation factor G domain IV is functionally important Academic Article
An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity Academic Article
An interchromosomal gene conversion of the Drosophila dunce locus identified with restriction site polymorphisms: a potential involvement of transposable elements in gene conversion Academic Article
An intracellular signal transduction pathway between the chloroplast and nucleus is involved in de-etiolation Academic Article
An isogenic human ESC platform for functional evaluation of genome-wide-association-study-identified diabetes genes and drug discovery Academic Article
An mrna-rrna base-pairing mechanism for translation initiation in eukaryotes Academic Article
An online resource for GPCR structure determination and analysis Academic Article
An orthogonal DNA replication system in yeast Academic Article
An unexpected outcome of surface engineering an integral membrane protein: Improved crystallization of cytochrome ba(3) from thermus thermophilus Academic Article
Analysis by electron-microscopy of early simian-virus 40 rna from a tsa mutant Academic Article
Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries Academic Article
Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor Academic Article
Analysis of individual immunoglobulin-lambda light-chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center b-cell somatic mutation Academic Article
Analysis of male pheromones that accelerate female reproductive organ development Academic Article
Analysis of novel residues of class I involved in recognition by alloreactive T cells Academic Article
Analysis of rrna processing and translation in mammalian cells using a synthetic 18s rrna expression system Academic Article
Analysis of stop-gain and frameshift variants in human innate immunity genes Academic Article
Analyzing and tuning ribozyme activity by deep sequencing to modulate gene expression level in mammalian cells Academic Article
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase Academic Article
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity Academic Article
Antibodies against small nuclear ribonucleoproteins immunoprecipitate complexes containing ts110 Moloney murine sarcoma virus genomic and messenger RNAs Academic Article
Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics Academic Article
Antigen presentation and t cell development in h2-m-deficient mice Academic Article
Antigen-driven B cell differentiation in vivo Academic Article
Antigenic analyses of influenza-virus hemagglutinins with different receptor-binding specificities Academic Article
Antisense masking reveals contributions of mrna- rrna base pairing to translation of gtx and fgf2 mrnas Academic Article
Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors Academic Article
Application of site-directed mutagenesis to rna and DNA genomes Academic Article
Approaches for skeletal gene therapy Academic Article
Arabidopsis MYB30 is a direct target of BES1 and cooperates with BES1 to regulate brassinosteroid-induced gene expression Academic Article
Arabidopsis thaliana mutant that develops as a light-grown plant in the absence of light Academic Article
Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation Academic Article
Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors Academic Article
Architecture of the flagellar rotor Academic Article
Arenavirus diversity and evolution: Quasispecies in vivo Academic Article
Arenavirus extinction through lethal mutagenesis Academic Article
Aromatic residues in the C-terminal region of glutathione transferase A1-1 influence rate-determining steps in the catalytic mechanism Academic Article
Article Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis Academic Article
Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein Academic Article
Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase Academic Article
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility Academic Article
Assembly of the covalent linkage between lipoic acid and its cognate enzymes Academic Article
Assignment of the L30-mRNA complex using selective isotopic labeling and RNA mutants Academic Article
Association between a disrupted-in-schizophrenia 1 (disc1) single nucleotide polymorphism and schizophrenia in a combined scandinavian case-control sample Academic Article
Association between thromboembolic events and the JAK2 V617F mutation in myeloproliferative neoplasms Academic Article
Association of the 2-mu-m DNA plasmid with yeast folded chromosomes Academic Article
Associations between phylogenetic clustering and HLA profile among HIV-infected individuals in San Diego, California Academic Article
Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificities Academic Article
Atl1 regulates choice between global genome and transcription-coupled repair of o-6-alkylguanines Academic Article
Atomic accuracy in predicting and designing noncanonical RNA structure Academic Article
Atomic structures of wild-type and thermostable mutant recombinant human cu,zn superoxide-dismutase Academic Article
Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex Academic Article
Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface Academic Article
Autoantibodies as reporters identifying aberrant cellular mechanisms in tumorigenesis Academic Article
Automated analysis of hypocotyl growth dynamics during shade avoidance in Arabidopsis Academic Article
Automated identification of functional dynamic contact networks from X-ray crystallography Academic Article
Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity Academic Article
Autoproteolysis in nucleoporin biogenesis Academic Article
Autoregulation of simian virus-40 gene-a by t-antigen Academic Article
Avian-sarcoma virus mutant that is temperature sensitive for virion assembly Academic Article
Avian-sarcoma virus prcii - conditional mutants temperature sensitive in the maintenance of fibroblast transformation Academic Article
Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential Academic Article
BACE1- and BACE2-expressing human cells - characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors Academic Article
BAS1: A gene regulating brassinosteroid levels and light responsiveness in Arabidopsis Academic Article
BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice Academic Article
BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation Academic Article
BIG: a calossin-like protein required for polar auxin transport in Arabidopsis Academic Article
BIN2, a new brassinosteroid-insensitive locus in Arabidopsis Academic Article
BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis Academic Article
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis Academic Article
BRANCHED1 interacts with FLOWERING LOCUS T to repress the floral transition of the axillary meristems in Arabidopsis Academic Article
BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint Academic Article
BRI1 is a critical component of a plasma-membrane receptor for plant steroids Academic Article
BRL1 and BRL3 are novel brassinosteroid receptors that function in vascular differentiation in Arabidopsis Academic Article
Bacillus subtilis chec and fliy are members of a novel class of chey-p-hydrolyzing proteins in the chemotactic signal transduction cascade Academic Article
Backbone-backbone H-bonds make context-dependent contributions to protein folding kinetics and thermodynamics: lessons from amide-to-ester mutations Academic Article
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin Academic Article
Balanced electrostatic and structural forces guide the large conformational change associated with maturation of t=4 virus Academic Article
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA Academic Article
Base pairing between hepatitis C virus RNA and 18S rRNA is required for IRES-dependent translation initiation in vivo Academic Article
Bcl-2 is an apoptotic target suppressed by both c-myc and e2f-1 Academic Article
Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis Academic Article
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3 Academic Article
Beware of multiple comparisons: A study of symptoms associated with mutations of the hfe hemochromatosis gene Academic Article
Biallelic mutations in IRF8 impair human NK cell maturation and function Academic Article
Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease Academic Article
Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome p450 46a1 unusual features and spectral response Academic Article
Binding of neural cell adhesion molecules (n-cams) to the cellular prion protein Academic Article
Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity Academic Article
Biobanking: an important resource for precision medicine in glioblastoma Academic Article
Biochemical characterization and crystal structure of a dim1 family associated protein: Dim2 Academic Article
Biochemical characterization of Arabidopsis wild-type and mutant phytochrome B holoproteins Academic Article
Biochemical characterization of the Caenorhabditis elegans FBF. CPB-1 translational regulation complex identifies conserved protein interaction hotspots Academic Article
Biochemical characterization of the tata-binding protein-gal4 activation domain complex Academic Article
Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1 Academic Article
Biochemical-characterization of the essential gtp-binding protein obg of bacillus-subtilis Academic Article
Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis Academic Article
Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants Academic Article
Biomarkers of endocannabinoid system activation in severe obesity Academic Article
Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes Academic Article
Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors Academic Article
Biosynthesis of the enediyne antitumor antibiotic c-1027 Academic Article
Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants Academic Article
Blockade of CD14 aggravates experimental shigellosis Academic Article
BluB cannibalizes flavin to form the lower ligand of vitamin B-12 Academic Article
Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of hfe, transferrin receptor 2 (tfr2), and il-6 Academic Article
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Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake Academic Article
Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients Academic Article
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc) Academic Article
Drosophila cyclic nucleotide phosphodiesterases Academic Article
Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol Academic Article
Dual role of TOC1 in the control of circadian and photomorphogenic responses in Arabidopsis Academic Article
Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins Academic Article
Dual selection of a genetic switch by a single selection marker Academic Article
Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system Academic Article
Dynamic simulations of the molecular conformations of wild type and mutant xanthan polymers suggest that conformational differences may contribute to observed differences in viscosity Academic Article
Dynamin gtpase domain mutants that differentially affect gtp binding, gtp hydrolysis, and clathrin-mediated endocytosis Academic Article
Dynamin-catalyzed membrane fission requires coordinated GTP hydrolysis Academic Article
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ELF3 modulates resetting of the circadian clock in Arabidopsis Academic Article
ENU-induced phenovariance in mice: Inferences from 587 mutations Academic Article
EPHA2 is associated with age-related cortical cataract in mice and humans Academic Article
ERdj3 Is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher's disease Academic Article
EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart Academic Article
Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase Academic Article
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Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion Academic Article
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Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza h5n1 viruses Academic Article
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Effects of transition metals on nitric oxide synthase catalysis Academic Article
Effects on bacillus-subtilis of a conditional-lethal mutation in the essential gtp-binding protein obg Academic Article
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Efficient t cell activation via a toll-interleukin 1 receptor-independent pathway Academic Article
Efficient transformation of chicken embryo fibroblasts by c-jun requires structural modification in coding and noncoding sequences Academic Article
Elemental concentrations in the seed of mutants and natural variants of Arabidopsis thaliana grown under varying soil conditions Academic Article
Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression Academic Article
Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice Academic Article
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Emergent properties of proteostasis in managing cystic fibrosis Academic Article
Endogenous plasmin converts Glu-plasminogen to Lys-plasminogen on the monocytoid cell surface Academic Article
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus Academic Article
Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling Academic Article
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Engineering complex riboswitch regulation by dual genetic selection Academic Article
Engineering naturally occurring trans-acting non-coding RNAs to sense molecular signals Academic Article
Engineering of substrate selectivity for tissue factor.Factor viia complex signaling through protease-activated receptor 2 Academic Article
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice Academic Article
Enhanced human-type receptor binding by ferret-transmissible H5N1 with a K193T mutation Academic Article
Enhanced major histocompatibility complex class i binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide Academic Article
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response Academic Article
Enrich: software for analysis of protein function by enrichment and depletion of variants Academic Article
Enrichment of sequencing targets from the human genome by solution hybridization Academic Article
Enzymatic detoxication, conformational selection, and the role of molten globule active sites Academic Article
Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila Academic Article
Epigenetic characterization of the fmr1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile x syndrome Academic Article
Epithelial membrane protein-1 is a biomarker of gefitinib resistance Academic Article
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Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein Academic Article
Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone Academic Article
Essential function in vivo for dicer-2 in host defense against rna viruses in drosophila Academic Article
Essential glycine in the proton channel of escherichia coli transhydrogenase Academic Article
Establishment of cell-lines persistently infected with foot-and-mouth-disease virus Academic Article
Ethanolamine activates a sensor histidine kinase regulating its utilization in enterococcus faecalis Academic Article
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Evasion of the p53 tumour surveillance network by tumour-derived myc mutants Academic Article
Evidence for a unique first position codon-anticodon mismatch in vivo Academic Article
Evidence for an intermediate conformational state of lacy Academic Article
Evidence for distinct locations for metal binding sites in two closely related class I tRNA synthetases Academic Article
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Evolution in vitro of an RNA enzyme with altered metal dependence Academic Article
Evolution in vitro: analysis of a lineage of ribozymes Academic Article
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Evolution of broad spectrum β-lactam resistance in an engineered metallo-β-lactamase Academic Article
Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling Academic Article
Evolution of glutathione transferases and related enzymes for the protection of cells against electrophiles Academic Article
Evolution of proteins with genetically encoded "chemical warheads" Academic Article
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template Academic Article
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Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme Academic Article
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Excess of rare amino acid polymorphisms in the toll-like receptor 4 in humans Academic Article
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Exonuclease 1-dependent and independent mismatch repair Academic Article
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Expanding the genetic code of Escherichia coli Academic Article
Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the golgi apparatus Academic Article
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FAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formation Academic Article
FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis Academic Article
FKF1F-BOX protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis Academic Article
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FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions Academic Article
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Far1 is required for posttranscriptional regulation of cln2 gene-expression in response to mating pheromone Academic Article
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation Academic Article
Fast folding mutants of the Tetrahymena group I ribozyme reveal a rugged folding energy landscape Academic Article
Fatal hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection in a patient with a novel mutation in the signaling lymphocytic activation molecule-associated protein Academic Article
Fbxw7/hcdc4 is a general tumor suppressor in human cancer Academic Article
Features of subunit nuom (nd4) in escherichia coli ndh-1 topology and implication of conserved glu(144) for coupling site 1 Academic Article
Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans Academic Article
Filopodia are required for cortical neurite initiation Academic Article
Fimbrin phosphorylation by metaphase Cdk1 regulates actin cable dynamics in budding yeast Academic Article
Fine definition of the CXCR4-binding region on the V3 loop of feline immunodeficiency virus surface glycoprotein Academic Article
Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region Academic Article
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Flower arranging in Arabidopsis Academic Article
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells Academic Article
Fluorescence turn-on folding sensor to monitor proteome stress in live cells Academic Article
Fluorotryptophan incorporation modulates the structure and stability of transthyretin in a site-specific manner Academic Article
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing Academic Article
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Folding of fibroblast growth factor 1 is critical for its nonclassical release Academic Article
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Forward genetics by sequencing EMS variation-induced inbred lines Academic Article
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Functional-analysis of the human tissue factor promoter and induction by serum Academic Article
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G-protein mutations that alter the pheromone response in saccharomyces-cerevisiae Academic Article
GIGANTEA directly activates Flowering Locus T in Arabidopsis thaliana Academic Article
GTPase traffic control Academic Article
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Galanin overexpressing transgenic mice Academic Article
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Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles Academic Article
Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR) Academic Article
Gene therapy for chronic viral hepatitis: ribozymes, antisense oligonucleotides, and dominant negative mutants Academic Article
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Genetic ablation of a mouse gene expressed specifically in brain Academic Article
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Genetic analysis of resistance to viral infection Academic Article
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis Academic Article
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Genetic dissection of innate immunity to infection: The mouse cytomegalovirus model Academic Article
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Genetic incorporation of histidine derivatives using an engineered pyrrolysyl-tRNA synthetase Academic Article
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Genetic mutations in ten unrelated american patients with symptomatic type-1 protein-C deficiency Academic Article
Genetic recombinants and heterozygotes derived from endogenous and exogenous avian RNA tumor viruses Academic Article
Genetic screening for low-penetrance variants in protein-coding genes Academic Article
Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300 Academic Article
Genetic variation in an individual human exome Academic Article
Genetic-analysis in bacillus-subtilis Academic Article
Genetic-analysis of a class of polymyxin resistant partial revertants of stage-o sporulation mutants of bacillus-subtilis - map of the chromosome region near the origin of replication Academic Article
Genetic-mapping of a linked cluster of ribosomal ribonucleic-acid genes in bacillus-subtilis Academic Article
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Genetics of alpha-ketoglutarate dehydrogenase complex of bacillus-subtilis Academic Article
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Global analysis of protein palmitoylation in yeast Academic Article
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Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases Academic Article
Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor Academic Article
Implication of a novel multiprotein Dam1p complex in outer kinetochore function Academic Article
Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation Academic Article
Importance of single molecular determinants in the fidelity of expanded genetic codes Academic Article
Improved breadth and potency of an hiv-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning Academic Article
Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant Academic Article
Improved identification of SUMO attachment sites using C-terminal SUMO mutants and tailored protease digestion strategies Academic Article
In silico screening against wild-type and mutant Plasmodium falciparum dihydrofolate reductase Academic Article
In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer Academic Article
In vitro evolution of a ribozyme that contains 5-bromouridine Academic Article
In vitro evolution of h5n1 avian influenza virus toward human-type receptor specificity Academic Article
In vitro selection of state-specific peptide modulators of G protein signaling using mRNA display Academic Article
In vitro site-directed mutagenesis: generation and properties of an infectious extracistronic mutant of bacteriophage Qbeta Academic Article
In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons Academic Article
In vivo incorporation of an alkyne into proteins in Escherichia coli Academic Article
In vivo manipulation of the bleomycin biosynthetic gene cluster in streptomyces verticillus atcc15003 revealing new insights into its biosynthetic pathway Academic Article
In vivo molecular evolution reveals biophysical origins of organismal fitness Academic Article
In vivo selection for the directed evolution of l-rhamnulose aldolase from l-rhamnulose-1-phosphate aldolase (rhad) Academic Article
In vivo study of the HC-TN strain of hepatitis C virus recovered from a patient with fulminant hepatitis: RNA transcripts of a molecular clone (pHC-TN) are infectious in chimpanzees but not in Huh7.5 cells Academic Article
Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage Academic Article
Increased functional stability and homogeneity of viral envelope spikes through directed evolution Academic Article
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice Academic Article
Increased lipid accumulation in the Chlamydomonas reinhardtii sta7-10 starchless isoamylase mutant and increased carbohydrate synthesis in complemented strains Academic Article
Increased mutation frequency of feline immunodeficiency virus lacking functional deoxyuridine-triphosphatase Academic Article
Increased susceptibility to DNA virus infection in mice with a GCN2 mutation Academic Article
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Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis Academic Article
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Induction of a cellular enzyme for energy metabolism by transforming domains of adenovirus E1a Academic Article
Induction of positive cooperativity by amino acid replacements within the C-terminal domain of penicillium chrysogenum ATP sulfurylase Academic Article
Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes Academic Article
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity Academic Article
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger Academic Article
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Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity Academic Article
Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic acid receptors Academic Article
Influenza virus-susceptible mice carry mx-genes with a large deletion or a nonsense mutation Academic Article
Inhibition of mutation and combating the evolution of antibiotic resistance Academic Article
Inhibition of viral replication by genetically engineered mutants of the duck hepatitis B virus core protein Academic Article
Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers Academic Article
Inorganic pyrophosphate (PPI) in pathologic calcification of articular cartilage Academic Article
Insertion of new sequences into the catalytic domain of an enzyme Academic Article
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Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations Academic Article
Insights into the molecular recognition of the 5 '-gnn-3 ' family of DNA sequences by zinc finger domains Academic Article
Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs Academic Article
Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization Academic Article
Interaction interface of human flap endonuclease-1 with its DNA substrates Academic Article
Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein Academic Article
Interaction of sp-a (surfactant protein a) with bacterial rough lipopolysaccharide (re-lps), and effects of sp-a on the binding of re-lps to cd14 and lps-binding protein Academic Article
Interaction of the Bacillus stearothermophilus ribosomal protein S15 with its 5 '-translational operator mRNA Academic Article
Interaction surface of the spo0a response regulator with the spo0e phosphatase Academic Article
Interactions between hy1 and gun mutants of Arabidopsis, and their implications for plastid/nuclear signalling Academic Article
Intercellular coupling confers robustness against mutations in the SCN circadian clock network Academic Article
Interfering with resistance to Smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma Academic Article
Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice Academic Article
Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue Academic Article
Internal structural features of E. coli glycyl-tRNA synthetase examined by subunit polypeptide chain fusions Academic Article
Internalization and vacuolar targeting of the brassinosteroid hormone receptor BRI1 are regulated by ubiquitination Academic Article
Intersection between the regulators of sister chromatid cohesion establishment and maintenance in budding yeast indicates a multi-step mechanism Academic Article
Interstice mutations that block site-to-site translocation of a misactivated amino acid bound to a class I tRNA synthetase Academic Article
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Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase Academic Article
Invariant NKT cells require autophagy to coordinate proliferation and survival signals during differentiation Academic Article
Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants Academic Article
Investigation of the mechanism of resistance to third-generation cephalosporins by class C beta-lactamases by using chemical complementation Academic Article
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Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1 alpha transcription Academic Article
Isolation and characterization of 2 genes encoding yeast mating pheromone signaling elements - cdc72 and cdc73 Academic Article
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JLK isocoumarin inhibitors: Selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo Academic Article
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Jun inhibits myogenic differentiation Academic Article
Jun, the oncoprotein Academic Article
K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling Academic Article
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Kinase mutations in human disease: Interpreting genotype-phenotype relationships Academic Article
Kinetic intermediates trapped by native interactions in RNA folding Academic Article
Kinetic properties of missense mutations in patients with glutathione synthetase deficiency Academic Article
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Kinetics of hairpin ribozyme cleavage in yeast Academic Article
Kinetochore biorientation in Saccharomyces cerevisiae requires a tightly folded conformation of the Ndc80 complex Academic Article
Knock-in mice reveal nonsense-mediated mRNA decay in the brain Academic Article
Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants Academic Article
Label transfer chemistry for the characterization of protein-protein interactions Academic Article
Lac repressor genetic map in real space Academic Article
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Large scale mutational and kinetic analysis of a self-hydrolyzing deoxyribozyme Academic Article
Late onset thrombosis in a case of severe protein S deficiency due to compound heterozygosity for PROS1 mutations Academic Article
Learning performance of normal and mutant Drosophila after repeated conditioning trials with discrete stimuli Academic Article
Leu628 of the kix domain of cbp is a key residue for the interaction with the mll transactivation domain Academic Article
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Ligand-induced conformational changes in the bacillus subtilis chemoreceptor mcpb determined by disulfide crosslinking in vivo Academic Article
Light activation of the LOV protein Vivid generates a rapidly exchanging dimer Academic Article
Light signals in leaf and chloroplast development: photoreceptors and downstream responses in search of a transduction pathway Academic Article
Light-dependent sequestration of TIMELESS by CRYPTOCHROME Academic Article
Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast Academic Article
Linking photoreceptor excitation to changes in plant architecture Academic Article
Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan Academic Article
Lipophilic regulator of a developmental switch in Caenorhabditis elegans Academic Article
Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway Academic Article
Localization and substrate selectivity of sea urchin multidrug (MDR) efflux transporters Academic Article
Location and architecture of the Caulobacter crescentus chemoreceptor array Academic Article
Location of the targets of the hpr-97, sacu32(hy), and sacq36(hy) mutations in upstream regions of the subtilisin promoter Academic Article
Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling Academic Article
Long-range effects and functional consequences of stabilizing mutations in the ankyrin repeat domain of IκBα Academic Article
Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase Academic Article
Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy Academic Article
Long-term persistent vesicular stomatitis-virus and rabies virus-infection of cells in vitro Academic Article
Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts Academic Article
Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock Academic Article
Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope Academic Article
Loss of sex discrimination and male-male aggression in mice deficient for trp2 Academic Article
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Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease Academic Article
Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller Academic Article
Lpr t-cell hyporesponsiveness to mitogens linked to deficient receptor-stimulated phosphoinositide hydrolysis Academic Article
Lys(842) in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer Academic Article
Macaque long-term nonprogressors resist superinfection with multiple cd8(+) t cell escape variants of simian immunodeficiency virus Academic Article
Mafa has strong cell transforming ability but is a weak transactivator Academic Article
Maintenance of genome stability in Saccharomyces cerevisiae Academic Article
Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape Academic Article
Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells Academic Article
Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck Academic Article
Map2 and tau bind longitudinally along the outer ridges of microtubule protofilaments Academic Article
Mapkk-independent activation of p38 alpha mediated by tab1-dependent autophosphorylation of p38 alpha Academic Article
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Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo Academic Article
Mapping the transition state of the WW domain beta-sheet Academic Article
Massively parallel functional analysis of BRCA1 RING domain variants Academic Article
Maturation of shark single-domain (ignar) antibodies: Evidence for induced-fit binding Academic Article
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Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade Academic Article
Measuring food intake and nutrient absorption in Caenorhabditis elegans Academic Article
Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, polynucleotide kinase Academic Article
Mechanism of activation of protein kinase JAK2 by the growth hormone receptor Academic Article
Mechanism of human antibody-mediated neutralization of Marburg virus Academic Article
Mechanism of transfection with deoxyribonucleic acid from temperate bacillus bacteriophage phi105 Academic Article
Mechanism-based post-translational modification and inactivation in terpene synthases Academic Article
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Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations Academic Article
Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides Academic Article
Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase Academic Article
Mechanistic properties of immunoglobulin somatic mutation Academic Article
Melanopsin-encoded response properties of intrinsically photosensitive retinal ganglion cells Academic Article
Melting of a DNA helix terminus within the active-site of a DNA-polymerase Academic Article
Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization Academic Article
Metal-binding 'finger' structures in the glucocorticoid receptor defined by site-directed mutagenesis Academic Article
Metastatic carcinomatous cirrhosis and hepatic hemosiderosis Academic Article
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function Academic Article
Microbial source tracking by DNA sequence analysis of the Escherichia coli malate dehydrogenase gene Academic Article
Microdroplet-based pcr enrichment for large-scale targeted sequencing Academic Article
Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features Academic Article
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Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients Academic Article
Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication Academic Article
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction Academic Article
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Mitotic misregulation and human aging Academic Article
Mitotic role for the cdc28-protein kinase of saccharomyces-cerevisiae Academic Article
Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe Academic Article
Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control Academic Article
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Modeling the inhibition of quadruple mutant Plasmodium falciparum dihydrofolate reductase by pyrimethamine derivatives Academic Article
Modeling with in vitro kinetic parameters for the elaboration of transfer RNA identity in vivo Academic Article
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Modulation of HIF-2α PAS-B domain contributes to physiological responses Academic Article
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ib-alpha Academic Article
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Molecular basis of viral persistence: a single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence Academic Article
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Molecular characterization of single memory b-cells Academic Article
Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions Academic Article
Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo - Rab-independent binding to membranes and role of Rab recycling factors Academic Article
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Molecular evolution of the Rab-escort-protein/guanine-nucleotide-dissociation-inhibitor superfamily Academic Article
Molecular genetics of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency Academic Article
Molecular genetics of transmissible spongiform encephalopathies Academic Article
Molecular mechanism of the sweet taste enhancers Academic Article
Molecular mechanisms of myocardial infarction Academic Article
Molecular methods for isolation of signal transduction pathway mutants Academic Article
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Molecular role for the Rab binding platform of guanine nucleotide dissociation inhibitor in endoplasmic reticulum to Golgi transport Academic Article
Molecular-biology approaches to genetic-defects of the mammalian nervous-system Academic Article
Molecular-cloning of bacillus-subtilis genes involved in DNA metabolism Academic Article
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Mouse hematopoietic stem-cells Academic Article
Mouse hematopoietic stem-cells and the interaction of c-kit receptor and steel factor Academic Article
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Mps1 phosphorylation of Dam1 couples kinetochores to microtubule plus ends at metaphase Academic Article
Mps1Mph1 kinase phosphorylates Mad3 to inhibit Cdc20Slp1-APC/C and maintain spindle checkpoint arrests Academic Article
MrHAMER yields highly accurate single molecule viral sequences enabling analysis of intra-host evolution Academic Article
Mss4 does not function as an exchange factor for Rab in endoplasmic reticulum to Golgi transport Academic Article
Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration Academic Article
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Multidimensional epistasis and fitness landscapes in enzyme evolution Academic Article
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Multiple large filament bundles observed in Caulobacter crescentus by electron cryotomography Academic Article
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Multiple pathways for suppression of mutants affecting g(1)-specific tip transcription in saccharomyces cerevisiae Academic Article
Multiple protein aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in bacillus-subtilis Academic Article
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Multiple topogenic sequences in bovine opsin Academic Article
Multivalent minigene vaccines against infectious disease Academic Article
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Murine tissue actor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality Academic Article
Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model Academic Article
Mushroom bodies and Drosophila learning Academic Article
Mutability of prions Academic Article
Mutagenesis by retroviral insertion in chemical mutagen-gene rated quasi-haploid mammalian cells Academic Article
Mutagenesis of mouse myeloma cells with Melphalan Academic Article
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Mutant aminoacyl-tRNA synthetase that compensates for a mutation in the major identity determinant of its tRNA Academic Article
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Mutants of dictyostelium-discoideum blocked in expression of all members of the developmentally regulated discoidin multigene family Academic Article
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Mutation analysis in hereditary hemochromatosis Academic Article
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Mutation of hcdc4 leads to cell cycle deregulation of cyclin e in cancer Academic Article
Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection Academic Article
Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis Academic Article
Mutational activation of c-raf-1 and definition of the minimal transforming sequence Academic Article
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction Academic Article
Mutational analysis of 48G7 reveals that somatic hypermutation affects both antibody stability and binding affinity Academic Article
Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay Academic Article
Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine Academic Article
Mutational analysis of ligand-binding activity of beta-2 adrenergic-receptor expressed in escherichia-coli Academic Article
Mutational analysis of membrane and soluble forms of human md-2 Academic Article
Mutational analysis of phosphodiesterase in Drosophila Academic Article
Mutational analysis of sulfite reductase hemoprotein reveals the mechanism for coordinated electron and proton transfer Academic Article
Mutational analysis of the Arabidopsis nucleotide binding site-leucine-rich repeat resistance gene RPS2 Academic Article
Mutational isolation of a sieve for editing in a transfer RNA synthetase Academic Article
Mutational separation of aminoacylation and cytokine activities of human tyrosyl-tRNA synthetase Academic Article
Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction Academic Article
Mutationally derived H-2 antigenic differences as defined by cytolytic T lymphocyte clones Academic Article
Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2 Academic Article
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Mutations in GDI1 are responsible for X-linked non-specific mental retardation Academic Article
Mutations in GNAL cause primary torsion dystonia Academic Article
Mutations in GNAL: a novel cause of craniocervical dystonia Academic Article
Mutations in NR4A2 associated with familial Parkinson disease Academic Article
Mutations in a gene encoding the alpha-subunit of a saccharomyces-cerevisiae g-protein indicate a role in mating pheromone signaling Academic Article
Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells Academic Article
Mutations in cell-division cycle genes cdc36 and cdc39 activate the saccharomyces-cerevisiae mating pheromone response pathway Academic Article
Mutations in human dynamin block an intermediate stage in coated vesicle formation Academic Article
Mutations in the hfe gene and cardiovascular disease risk an individual patient data meta-analysis of 53 880 subjects Academic Article
Mutations in the regulatory domain of phenylalanine hydroxylase and response to tetrahydrobiopterin Academic Article
Mutations that affect dimer formation and helicase activity of the hepatitis C virus helicase Academic Article
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Myc rescue of a mutant csf-1 receptor impaired in mitogenic signaling Academic Article
Myc signaling via the arf tumor suppressor regulates p53-dependent apoptosis and immortalization Academic Article
Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by e2f1 loss Academic Article
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Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 map kinase Academic Article
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Myristoylation of the RING finger Z protein is essential for arenavirus budding Academic Article
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans Academic Article
N-glycosylation is essential for vesicular targeting of synaptotagmin 1 Academic Article
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NF kappa B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Academic Article
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Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells Academic Article
Naturally death-resistant precursor cells revealed as the origin of retinoblastoma Academic Article
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair Academic Article
Negative regulation of g(1) and g(2) by s-phase cyclins of saccharomyces cerevisine Academic Article
Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2 Academic Article
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Negative selection and stringency modulation in phage-assisted continuous evolution Academic Article
Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape Academic Article
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Networks link antigenic and receptor-binding sites of influenza hemagglutinin: Mechanistic insight into fitter strain propagation Academic Article
NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus Academic Article
Neurexin-neuroligin transsynaptic interaction mediates learning-related synaptic remodeling and long-term facilitation in aplysia Academic Article
Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases Academic Article
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity Academic Article
Neutralizing mutations of carboxylates that bind metal 2 in t5 flap endonuclease result in an enzyme that still requires two metal ions Academic Article
New Arabidopsis cue mutants suggest a close connection between plastid- and phytochrome regulation of nuclear gene expression Academic Article
New addresses on an addressable virus nanoblock: Uniquely reactive lys residues on cowpea mosaic virus Academic Article
New cluster of ribosomal genes in bacillus-subtilis with regulatory role in sporulation Academic Article
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix Academic Article
New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: analysis of the epidermal growth factor-like repeat A docking site using WaterMap Academic Article
Niche partitioning in the coevolution of 2 distinct RNA enzymes Academic Article
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Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity Academic Article
Non-conventional trafficking of the cystic fibrosis transmembrane conductance regulator through the early secretory pathway Academic Article
Noncanonical NF-kappa B signaling is limited by classical NF-kappa B activity Academic Article
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Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity Academic Article
Noncoded amino acid replacement probes of the aspartate aminotransferase mechanism Academic Article
Nonconditional replication-defective mutant of the schmidt-ruppin strain of rous-sarcoma virus Academic Article
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Not more than 117 base-pairs of 5'-flanking sequence are required for inducible expression of a human ifn-alpha gene Academic Article
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Nuclear lamina at the crossroads of the cytoplasm and nucleus Academic Article
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Nucleotide-sequence heterogeneity of an rna phage population Academic Article
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Oncogene alterations in primary human-colon tumors Academic Article
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Oncogenic signaling of class ipi3k isoforms Academic Article
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Optimized clinical performance of growth hormone with an expanded genetic code Academic Article
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Out of darkness: mutants reveal pathways controlling light-regulated development in plants Academic Article
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Overcoming mutation-based resistance to antiandrogens with rational drug design Academic Article
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Oxidation inhibits amyloid fibril formation of transthyretin Academic Article
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P38 beta MAP kinase protects rat mesangial cells from TNF-alpha-induced apoptosis Academic Article
P45(skp2) promotes p27(kip1) degradation and induces s phase in quiescent cells Academic Article
PER1 phosphorylation specifies feeding rhythm in mice Academic Article
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PPARG post-translational modifications regulate bone formation and bone resorption Academic Article
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Palmitoylation-dependent activation of MC1R prevents melanomagenesis Academic Article
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma Academic Article
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Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis Academic Article
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Pathogenic mutations induce partial structural changes in the native β-sheet structure of transthyretin and accelerate aggregation Academic Article
Patient-derived models of acquired resistance can identify effective drug combinations for cancer Academic Article
Pedigree models for complex human traits involving the mitochondrial genome Academic Article
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Personalized circulating tumor DNA biomarkers dynamically predict treatment response and survival in gynecologic cancers Academic Article
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Phage-display evolution of tyrosine kinases with altered nucleotide specificity Academic Article
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Phosphoinositide 3-kinase: From viral oncoprotein to drug target Academic Article
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Phytochrome signaling mechanisms and the control of plant development Academic Article
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Proteasome-Mediated Turnover of Arabidopsis MED25 Is Coupled to the Activation of FLOWERING LOCUS T Transcription Academic Article
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Proteomics opens doors to the mechanisms of developmentally regulated secretion Academic Article
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Purdue ionomics information management system. An integrated functional genomics platform Academic Article
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QQS orphan gene regulates carbon and nitrogen partitioning across species via NF-YC interactions Academic Article
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Quantitative proteomics and protein network analysis of hippocampal synapses of CaMKII alpha mutant mice Academic Article
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RNA-RNA interactions between oligonucleotide substrates for aminoacylation Academic Article
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Release factor one is nonessential in Escherichia coli Academic Article
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Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells Academic Article
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Tyrosine cross-linking reveals interfacial dynamics in adeno-associated viral capsids during infection Academic Article
Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase inhibitor Academic Article
UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin Academic Article
Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling Academic Article
Ubiquitin facilitates a quality-control pathway that removes damaged chloroplasts Academic Article
Ubiquitin ligase activity of tfiih and the transcriptional response to DNA damage Academic Article
Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production Academic Article
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates Academic Article
Ubiquitylation of cyclin e requires the sequential function of scf complexes containing distinct hcdc4 isoforms Academic Article
Ultra-potent antibodies against respiratory syncytial virus: effects of binding kinetics and binding valence on viral neutralization Academic Article
Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier Academic Article
Ultrahigh and high resolution structures and mutational analysis of monomeric streptococcus pyogenes speb reveal a functional role for the glycine-rich c-terminal loop Academic Article
Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection Academic Article
Understanding the enzymatic activity of 4-oxalocrotonate tautomerase and its mutant analogues: A computational study Academic Article
Unfolded proteins and protein folding studied by NMR Academic Article
Unique domain appended to vertebrate tRNA synthetase is essential for vascular development Academic Article
Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations Academic Article
Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene Academic Article
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded rna occurs by trif-dependent and trif-independent pathways Academic Article
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in plasmodium falciparum Academic Article
Use of silent mutations in cDNA encoding human glutathione transferase M2-2 for optimized expression in Escherichia coli Academic Article
Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors Academic Article
VH11 bias and normal V-D-J junctions in SCID B lymphocytes rescued by neonatal T cell transfer Academic Article
VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses Academic Article
Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention Academic Article
Validation of isoleucine utilization targets in plasmodium falciparum Academic Article
Variability of thrombosis among homozygous siblings with resistance to activated protein-C due to an Arg- Gln mutation in the gene for factor-V Academic Article
Variable region sequences of murine igm anti-igg monoclonal autoantibodies (rheumatoid factors) - a structural explanation for the high-frequency of igm anti-igg b-cells Academic Article
Variant-proof vaccines - invest now for the next pandemic Academic Article
Vav and ras induce fibroblast transformation by overlapping signaling pathways, which require c-myc function Academic Article
Velvet, a dominant egfr mutation that causes wavy hair and defective eyelid development in mice Academic Article
Viral mutations, TCR antagonism and escape from the immune-response Academic Article
Virus lymphocyte interactions .4. Molecular characterization of lcmv armstrong (ctl+) small genomic segment and that of its variant, clone-13 (ctl-) Academic Article
Virus maturation targets the protein capsid to concerted disassembly and unfolding Academic Article
Virus persistence and recurring demyelination produced by a temperature-sensitive mutant of mhv-4 Academic Article
Virus-induced immunosuppression - kinetic-analysis of the selection of a mutation associated with viral persistence Academic Article
Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide Academic Article
Whi5 regulation by site specific cdk-phosphorylation in saccharomyces cerevisiae Academic Article
Whole-genome mutational burden analysis of three pluripotency induction methods Academic Article
Whole-genome sequencing and microarray analysis of ex vivo plasmodium vivax reveal selective pressure on putative drug resistance genes Academic Article
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C Academic Article
Xenobiotic metabolism and mutation in a human lymphoblastoid cell line Academic Article
Xpd helicase structures and activities: Insights into the cancer and aging phenotypes from xpd mutations Academic Article
Yeast LEU5 is a PET-like gene that is not essential for leucine biosynthesis Academic Article
Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice Academic Article
ZBTB1 is a determinant of lymphoid development Academic Article
Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates. A mini-review Academic Article
hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene Academic Article
hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function Academic Article
kurtz, a novel nonvisual arrestin, is an essential neural gene in Drosophila Academic Article
l(3)malignant brain tumor and three novel genes are required for Drosophila germ-cell formation Academic Article
mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1 Academic Article
roX1 RNA paints the X chromosome of male Drosophila and is regulated by the dosage compensation system Academic Article
tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the Arabidopsis circadian oscillator Academic Article
β-hairpin-mediated nucleation of polyglutamine amyloid formation Academic Article

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