subject area of

• 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation  Academic Article
• 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia  Academic Article
• 11-deoxy prostaglandin F(2 alpha), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3(-/-) females  Academic Article
• 5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission  Academic Article
• 5-HT(7) receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern  Academic Article
• 5-aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor alpha-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent  Academic Article
• A 3-dimensional extracellular matrix as a delivery system for the transplantation of glioma-targeting neural stem/progenitor cells  Academic Article
• A 5' leader of Rbm3, a cold stress-induced mRNA, mediates internal initiation of translation with increased efficiency under conditions of mild hypothermia  Academic Article
• A DNA vaccine against vegf receptor 2 prevents effective angiogenesis and inhibits tumor growth  Academic Article
• A DNA vaccine targeting fos-related antigen 1 enhanced by il-18 induces long-lived t-cell memory against tumor recurrence  Academic Article
• A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication  Academic Article
• A Jekyll and Hyde profile: Type 1 interferon signaling plays a prominent role in the initiation and maintenance of a persistent virus infection  Academic Article
• A ZAP-70 kinase domain variant prevents thymocyte- positive selection despite signalling CD69 induction  Academic Article
• A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation  Academic Article
• A catechol-O-methyltransferase that is essential for auditory function in mice and humans  Academic Article
• A chemically induced vaccine strategy for prostate cancer  Academic Article
• A chimeric mouse model of Gaucher disease  Academic Article
• A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol  Academic Article
• A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy  Academic Article
• A derivative of the melanocortin receptor antagonist shu9119 (pg932) increases food intake when administered peripherally  Academic Article
• A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use  Academic Article
• A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4(-)CD8(-) to CD4(+) CD8(+) thymocytes  Academic Article
• A dual role for microglia in promoting tissue inhibitor of metalloproteinase (timp) expression in glial cells in response to neuroinflammatory stimuli  Academic Article
• A factor IX-deficient mouse model for hemophilia B gene therapy  Academic Article
• A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function  Academic Article
• A functional genomics strategy reveals Rora as a component of the mammalian circadian clock  Academic Article
• A genetic determinant that specifically regulates the frequency of hematopoietic stem cells  Academic Article
• A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing  Academic Article
• A gfp-equipped bidirectional expression module well suited for monitoring tetracycline-regulated gene expression in mouse  Academic Article
• A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity  Academic Article
• A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia  Academic Article
• A keratinocyte-responsive gamma delta tcr is necessary for dendritic epidermal t cell activation by damaged keratinocytes and maintenance in the epidermis  Academic Article
• A lack of mu-opioid receptors modulates the expressions of neuropeptide y and substance p mrna  Academic Article
• A leukocyte homologue of the il-8 receptor cxcr-2 mediates the accumulation of macrophages in atherosclerotic lesions of ldl receptor-deficient mice  Academic Article
• A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses  Academic Article
• A major histocompatibility complex class I-dependent subset of memory phenotype CD8(+) cells  Academic Article
• A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration  Academic Article
• A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice  Academic Article
• A multivalent minigene vaccine, containing b-cell, cytotoxic t-lymphocyte, and t-h epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen  Academic Article
• A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen  Academic Article
• A new UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase mRNA exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain  Academic Article
• A novel DNA vaccine encoding pdgfr beta suppresses growth and dissemination of murine colon, lung and breast carcinoma  Academic Article
• A novel ELISA for mouse activated protein C in plasma  Academic Article
• A novel allele of myosin viia reveals a critical function for the c-terminal ferm domain for melanosome transport in retinal pigment epithelial cells  Academic Article
• A novel and simple method for culturing pericytes from mouse brain  Academic Article
• A novel approach for in vivo measurement of mouse red cell redox status  Academic Article
• A novel class II MHC molecule with unusual tissue distribution  Academic Article
• A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects  Academic Article
• A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis  Academic Article
• A novel generation of heparan sulfate mimetics for the treatment of prion diseases  Academic Article
• A novel method for analysis of nuclear receptor function at natural promoters: Peroxisome proliferator-activated receptor gamma agonist actions on ap2 gene expression detected using branched DNA messenger rna quantitation  Academic Article
• A novel method to establish microglia-free astrocyte cultures: Comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia  Academic Article
• A novel neuron-specific DNA end-binding factor in the murine brain  Academic Article
• A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1β  Academic Article
• A novel transgenic mouse model for immunological evaluation of carcinoembryonic antigen-based DNA minigene vaccines  Academic Article
• A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests  Academic Article
• A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects  Academic Article
• A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration  Academic Article
• A peptide that antagonizes tcr-mediated reactions with both syngeneic and allogeneic agonists: Functional and structural aspects  Academic Article
• A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones  Academic Article
• A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins  Academic Article
• A photo-cleavable biotin affinity tag for the facile release of a photo-crosslinked carbohydrate-binding protein  Academic Article
• A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase ii in t cells: From activation to unresponsiveness  Academic Article
• A point mutation in sec61 alpha 1 leads to diabetes and hepatosteatosis in mice  Academic Article
• A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding  Academic Article
• A population of murine gamma delta T cells that recognize an inducible MHC class Ib molecule  Academic Article
• A possible oligosaccharide-conjugate vaccine candidate for Clostridium difficile is antigenic and immunogenic  Academic Article
• A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake  Academic Article
• A ppar gamma-lxr-abca1 pathway in macrophages is involved in cholesterol efflux and atherogenesis  Academic Article
• A proapoptotic peptide for the treatment of solid tumors  Academic Article
• A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions  Academic Article
• A rabbit antiserum detects a vh j558 subgroup marker highly expressed among anti-alprenolol antibodies  Academic Article
• A regenerative approach to the treatment of multiple sclerosis  Academic Article
• A reversible S-adenosyl-L-homocysteine hydrolase inhibitor ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell activation  Academic Article
• A role for dual viral hits in causation of subacute sclerosing panencephalitis  Academic Article
• A role for skin γδ T cells in wound repair  Academic Article
• A role for tcr affinity in regulating naive t cell homeostasis  Academic Article
• A role for the GIRK3 subunit in methamphetamine-induced aAttenuation of GABA(B) receptor-activated GIRK currents in VTA dopamine neurons  Academic Article
• A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition  Academic Article
• A role of the fast ATP-gated P2X(1) cation channel in thrombosis of small arteries in vivo  Academic Article
• A secreted Slit2 fragment regulates adipose tissue thermogenesis and metabolic function  Academic Article
• A semisynthetic carbohydrate-lipid vaccine that protects against S-pneumoniae in mice  Academic Article
• A shared neural ensemble links distinct contextual memories encoded close in time  Academic Article
• A spontaneous rheumatoid arthritis-like disease in mrl/1 mice  Academic Article
• A spontaneously arising pancreatic tumor does not promote the differentiation of naive CD8+ T lymphocytes into effector CTL  Academic Article
• A stress response pathway regulates DNA damage through beta(2)-adrenoreceptors and beta-arrestin-1  Academic Article
• A string-of-beads vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge  Academic Article
• A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation  Academic Article
• A study of complexes of class II invariant chain peptide: major histocompatibility complex class II molecules using a new complex-specific monoclonal antibody  Academic Article
• A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors  Academic Article
• A t-cell receptor-v-alpha region selectively expressed in cd4+ cells  Academic Article
• A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria  Academic Article
• A transgenic mouse model for measles virus infection of the brain  Academic Article
• A transgenic mouse model of the chronic hepatitis B surface antigen carrier state  Academic Article
• A transgenic mouse model to assess the interaction of cytotoxic t-lymphocytes with virally infected, class-i mhc-expressing astrocytes  Academic Article
• A v(h)11v(kappa)9b cell antigen receptor drives generation of cd5(+) b cells both in vivo and in vitro  Academic Article
• A view from above: Cloud plots to visualize global metabolomic data  Academic Article
• A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes  Academic Article
• ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC  Academic Article
• ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells  Academic Article
• AMPAR-independent effect of striatal αCaMKII promotes the sensitization of cocaine reward  Academic Article
• ASPP2 deficiency causes features of 1q41q42 microdeletion syndrome  Academic Article
• ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor  Academic Article
• ATP-sensitive potassium channel (K-ATP)-dependent regulation of cardiotropic viral infections  Academic Article
• Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6  Academic Article
• Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity  Academic Article
• Ablation of cd22 in ligand-deficient mice restores b cell receptor signaling  Academic Article
• Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice  Academic Article
• Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model  Academic Article
• Absence of CTL responses to early viral antigens facilitates viral persistence  Academic Article
• Absence of LPA1 signaling results in defective cortical development  Academic Article
• Absence of carbohydrate response element binding protein in adipocytes causes systemic insulin resistance and impairs glucose transport  Academic Article
• Absence of the alpha v beta 3 integrin dictates the time-course of angiogenesis in the hypoxic central nervous system: Accelerated endothelial proliferation correlates with compensatory increases in alpha 5 beta 1 integrin expression  Academic Article
• Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass  Academic Article
• Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice  Academic Article
• Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1  Academic Article
• Activated protein C preserves functional islet mass after intraportal transplantation - a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death  Academic Article
• Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3  Academic Article
• Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1  Academic Article
• Activated protein C targets CD8(+) dendritic cells to reduce the mortality of endotoxemia in mice  Academic Article
• Activation kinetics and off-target effects of thymus-initiated cre transgenes  Academic Article
• Activation of PPARdelta alters lipid metabolism in db/db mice  Academic Article
• Activation of liver x receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue  Academic Article
• Activation of lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury  Academic Article
• Activation of multidrug resistance (P-glycoprotein) mdr3/mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice  Academic Article
• Activation of murine cd4(+) and cd8(+) t lymphocytes leads to dramatic remodeling of n-linked glycans  Academic Article
• Activation of preexisting t cell clones by targeted interleukin 2 therapy  Academic Article
• Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats  Academic Article
• Activation of the alternative complement pathway by fetal calf serum and mouse thymocytes  Academic Article
• Activation of the endocannabinoid system by organophosphorus nerve agents  Academic Article
• Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins  Academic Article
• Activators of the nuclear receptor ppar gamma enhance colon polyp formation  Academic Article
• Acute exposure to cxc chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices  Academic Article
• Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice  Academic Article
• Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-- Jakob disease: implications for human health  Academic Article
• Adenoviral delivery of CTLA4ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients  Academic Article
• Adenoviral-mediated, intratumor gene transfer of interleukin 23 induces a therapeutic antitumor response  Academic Article
• Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice  Academic Article
• Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone  Academic Article
• AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin  Academic Article
• Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs  Academic Article
• Adjuvant activity of the histamine-sensitizing factor of Bordetella pertussis in different strains of mice  Academic Article
• Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice  Academic Article
• Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling  Academic Article
• Administration of systemic or local interleukin-2 enhances the antitumor effects of interleukin-12 gene-therapy  Academic Article
• Adoptive immunotherapy induces cns dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection  Academic Article
• Adoptive transfer of fluorescence-labeled cells shows that resident peritoneal-macrophages are able to migrate into specialized lymphoid organs and inflammatory sites in the mouse  Academic Article
• Adropin deficiency is associated with increased adiposity and insulin resistance  Academic Article
• Adult mice generated from induced pluripotent stem cells  Academic Article
• Afamin secreted from nonresorbing osteoclasts acts as a chemokine for preosteoblasts via the Akt-signaling pathway  Academic Article
• Age- and gender-specific changes of hypocretin immunopositive neurons in C57Bl/6 mice  Academic Article
• Age-dependent loss of sperm production in mice via impaired tysophosphatidic acid signaling  Academic Article
• Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability  Academic Article
• Aged app23 mice show a delay in switching to the use of a strategy in the barnes maze  Academic Article
• Aging accelerates endotoxin-induced thrombosis: increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging  Academic Article
• Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue  Academic Article
• Aging leads to disturbed homeostasis of memory phenotype cd8(+) cells  Academic Article
• Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics  Academic Article
• Allelic exclusion of mouse t-cell receptor-alpha chains occurs at the time of thymocyte tcr up-regulation  Academic Article
• Allelic exclusion of the tcr alpha-chain is an active process requiring tcr-mediated signaling and c-cbl  Academic Article
• Alloantibodies can discriminate class I major histocompatibility complex molecules associated with various endogenous peptides  Academic Article
• Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus  Academic Article
• Allosteric activators of glucokinase: potential role in diabetes therapy  Academic Article
• Alpha 8 integrin in glomerular mesangial cells and in experimental glomerulonephritis  Academic Article
• Alterations in neural cell-adhesion molecules during development of different regions of the nervous-system  Academic Article
• Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice  Academic Article
• Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor  Academic Article
• Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus  Academic Article
• Altered functional and biochemical response by CD8+ T cells that remain after tolerance  Academic Article
• Altered helper T lymphocyte function associated with chronic hepatitis B virus infection and its role in response to therapeutic vaccination in humans  Academic Article
• Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6  Academic Article
• Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1 alpha  Academic Article
• Alternatively spliced tissue factor induces angiogenesis through integrin ligation  Academic Article
• Amelioration of chronic murine colitis by peptide-mediated transduction of the I kappa B kinase inhibitor NEMO binding domain peptide  Academic Article
• Amisulpride is a potent 5-ht(7) antagonist: Relevance for antidepressant actions in vivo  Academic Article
• Among cxcr3 chemokines, ifn-gamma-inducible protein of 10 kda (cxc chemokine ligand (cxcl) 10) but not monokine induced by ifn-gamma (cxcl9) imprints a pattern for the subsequent development of autoimmune disease  Academic Article
• Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction  Academic Article
• Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD  Academic Article
• Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: A possible model for senile systemic amyloidosis  Academic Article
• Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model  Academic Article
• An IRF-3-, IRF-5-, and IRF-7-independent pathway of dengue viral resistance utilizes IRF-1 to stimulate type I and II interferon responses  Academic Article
• An activated protein c analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents  Academic Article
• An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model  Academic Article
• An activity-based imaging probe for the integral membrane hydrolase KIAA1363  Academic Article
• An ahemolytic pneumolysin of Streptococcus pneumoniae manipulates human innate and CD4⁺ T-cell responses and reduces resistance to colonization in mice in a serotype-independent manner  Academic Article
• An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription  Academic Article
• An angiogenic role for the alpha 5 beta 1 integrin in promoting endothelial cell proliferation during cerebral hypoxia  Academic Article
• An anti-apoptotic peptide improves survival in lethal total body irradiation  Academic Article
• An antibody-interleukin 2 fusion protein overcomes tumor heterogeneity by induction of a cellular immune response  Academic Article
• An apolipoprotein e synthetic peptide targets to lipoproteins in plasma and mediates both cellular lipoprotein interactions in vitro and acute clearance of cholesterol-rich lipoproteins in vivo  Academic Article
• An autologous oral DNA vaccine protects against murine melanoma  Academic Article
• An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. II. Mammalian fibroblast cultures transformed by DNA and RNA tumor viruses  Academic Article
• An essential role for Rxr alpha in the development of Th2 responses  Academic Article
• An oral DNA vaccine against human carcinoembryonic antigen (cea) prevents growth and dissemination of lewis lung carcinoma in cea transgenic mice  Academic Article
• Analysis of antigen-specific B-cell memory directly ex vivo  Academic Article
• Analysis of central b cell tolerance in autoimmune-prone mrl/lpr mice bearing autoantibody transgenes  Academic Article
• Analysis of individual immunoglobulin-lambda light-chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center b-cell somatic mutation  Academic Article
• Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools  Academic Article
• Analysis of the MCMV resistome by ENU mutagenesis  Academic Article
• Analysis of the effect of estrogen/androgen perturbation on penile development in transgenic and diethylstilbestrol-Treated mice  Academic Article
• Analysis of the proteolysis of bioactive peptides using a peptidomics approach  Academic Article
• Analysis of the therapeutic functions of novel melanocortin receptor agonists in mc3r-and mc4r-deficient c57bl/6j mice  Academic Article
• Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum  Academic Article
• Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors  Academic Article
• Anchorless prion protein results in infectious amyloid disease without clinical scrapie  Academic Article
• Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development  Academic Article
• Angiomotin regulates endothelial cell migration during embryonic angiogenesis  Academic Article
• Animal model of respiratory syncytial virus: CD8(+) T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy  Academic Article
• Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation  Academic Article
• Antagonizing peroxisome proliferator-activated receptor α activity selectively enhances Th1 immunity in male mice  Academic Article
• Anti-Gag cytolytic T lymphocytes specific for an alternative translational reading frame-derived epitope and resistance versus susceptibility to retrovirus-induced murine AIDS in F(1) mice  Academic Article
• Anti-IFN-alpha/beta receptor antibody treatment ameliorates disease in lupus-predisposed mice  Academic Article
• Anti-OX40 stimulation in vivo enhances CD8(+) memory T cell survival and significantly increases recall responses  Academic Article
• Anti-apoptotic peptides protect against radiation-induced cell death  Academic Article
• Anti-cd11b antibody prevents immunopathologic changes in viable moth-eaten bone-marrow chimeric mice  Academic Article
• Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones  Academic Article
• Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke  Academic Article
• Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37  Academic Article
• Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism  Academic Article
• Anticonvulsant activity of a nonpeptide galanin receptor agonist  Academic Article
• Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation  Academic Article
• Antidiabetic activity of a highly potent and selective nonpeptide somatostatin receptor subtype-2 agonist  Academic Article
• Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin/cd169  Academic Article
• Antigen presentation in retroviral vector-mediated gene transfer in vivo  Academic Article
• Antigen-driven B cell differentiation in vivo  Academic Article
• Antigen-induced unresponsiveness results in altered t cell signaling  Academic Article
• Antigen-specific b cell memory: Expression and replenishment of a novel b220(-) memory b cell compartment  Academic Article
• Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency  Academic Article
• Antigen-specific naive CD8(+) T cells produce a single pulse of IFN-gamma in vivo within hours of infection, but without antiviral effect  Academic Article
• Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis  Academic Article
• Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress  Academic Article
• Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids - recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein  Academic Article
• Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus  Academic Article
• Antiproliferation activity of a small molecule repressor of liver receptor homolog 1  Academic Article
• Antipsychotic drug treatment alters expression of mrnas encoding lipid metabolism-related proteins  Academic Article
• Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models  Academic Article
• Anxiolytic-Like Effects of Antisauvagine-30 in Mice Are Not Mediated by CRF2 Receptors  Academic Article
• ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo  Academic Article
• Apoa1 reduces free cholesterol accumulation in atherosclerotic lesions of apoe-deficient mice transplanted with apoe-expressing macrophages  Academic Article
• Architecture of cannabinoid signaling in mouse retina  Academic Article
• Area specificity and topography of thalamocortical projections are controlled by ephrin/eph genes  Academic Article
• Arenavirus genome rearrangement for the development of live attenuated vaccines  Academic Article
• Arginine 54 and tyrosine 118 residues of αA-crystallin are crucial for lens formation and transparency  Academic Article
• Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction  Academic Article
• Arylsulfonamide kcn1 inhibits in vivo glioma growth and interferes with hif signaling by disrupting hif-1 alpha interaction with cofactors p300/cbp  Academic Article
• Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord  Academic Article
• Assessing interactions between Ghsr and Mc3r reveals a role for AgRP in the expression of food anticipatory activity in male mice  Academic Article
• Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors  Academic Article
• Association of cartilage-specific deletion of peroxisome proliferator-activated receptor gamma with abnormal endochondral ossification and impaired cartilage growth and development in a murine model  Academic Article
• Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina  Academic Article
• Astrocyte pVHL and HIF-alpha isoforms are required for embryonic-to-adult vascular transition in the eye  Academic Article
• Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis  Academic Article
• Astrocytes contribute to gamma oscillations and recognition memory  Academic Article
• Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming  Academic Article
• Atheroprotective potential of macrophage-derived phospholipid transfer protein in low-density lipoprotein receptor-deficient mice is overcome by apolipoprotein ai overexpression  Academic Article
• Atherosclerosis in mice is not affected by a reduction in tissue factor expression  Academic Article
• Attenuation of allergic contact dermatitis through the endocannabinoid system  Academic Article
• Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: Involvement of regulatory T cells  Academic Article
• Aurora kinases a and b are up-regulated by myc and are essential for maintenance of the malignant state  Academic Article
• Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects  Academic Article
• Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells  Academic Article
• Autologous regulation of naive t cell homeostasis within the t cell compartment  Academic Article
• Automatic annotation of matrix-assisted laser desorption/ionization n-glycan spectra  Academic Article
• Autophagy activation by rapamycin reduces severity of experimental osteoarthritis  Academic Article
• Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis  Academic Article
• Autotaxin and lysophosphatidic acid(1) receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine  Academic Article
• Avidity of cd1d-ligand-receptor ternary complex contributes to t-helper 1 (th1) polarization and anticancer efficacy  Academic Article
• Azetidine and piperidine carbamates as efficient, covalent inhibitors of monoacylglycerol lipase  Academic Article
• B cell selection defects underlie the development of diabetogenic apcs in nonobese diabetic mice  Academic Article
• B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates  Academic Article
• B-cell development in mice that lack one or both immunoglobulin kappa-light chain genes  Academic Article
• B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of v-beta-5(+) thymocytes  Academic Article
• B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function  Academic Article
• BCR engagement induces Fas resistance in primary B cells in the absence of functional Bruton's tyrosine kinase  Academic Article
• BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice  Academic Article
• BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission  Academic Article
• BK channel β1 subunit contributes to behavioral adaptations elicited by chronic intermittent ethanol exposure  Academic Article
• Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid.  Academic Article
• Barx2 is expressed in satellite cells and is required for normal muscle growth and regeneration  Academic Article
• Basomedial amygdala mediates top-down control of anxiety and fear  Academic Article
• Bax loss impairs myc-induced apoptosis and circumvents the selection of p53 mutations during myc-mediated lymphomagenesis  Academic Article
• Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis  Academic Article
• Bcr ligation induces receptor editing in igm(+)igd(-) bone marrow b cells in vitro  Academic Article
• Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex  Academic Article
• Behavioral and neural correlates of acute and scheduled hunger in C57BL/6 mice  Academic Article
• Behavioral and neurochemical studies on brain aging in galanin overexpressing mice  Academic Article
• Behavioral phenotype of maLPA1-null mice: Increased anxiety-like behavior and spatial memory deficits  Academic Article
• Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory  Academic Article
• Beta 2-microglobulin is required for the full expression of xenobiotic-induced systemic autoimmunity  Academic Article
• Beta 8 integrin and band 4.1b cooperatively regulate morphogenesis of the embryonic heart  Academic Article
• Beyond the 12/23 rule of VDJ recombination independent of the Rag proteins  Academic Article
• Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis  Academic Article
• Binding of thymus- and bone marrow-derived lymphoid cells to antigen-derivatized fibers  Academic Article
• Biogenic amine synthesis and uptake in rodent taste buds  Academic Article
• Bioinformatic analysis of circadian gene oscillation in mouse aorta  Academic Article
• Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants  Academic Article
• Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. V. Recognition is restricted to gene products encoded by the viral S RNA segment  Academic Article
• Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. VI. Migration and activity in vivo in acute and persistent infection  Academic Article
• Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo  Academic Article
• Biomagnetic isolation of antigen-specific CD8(+) T cells usable in immunotherapy  Academic Article
• Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection  Academic Article
• Biphasic effect of melanocortin agonists on metabolic rate and body temperature  Academic Article
• Bisphosphonates target B cells to enhance humoral immune responses  Academic Article
• Bitopic sphingosine 1-phosphate receptor 3 (S1P3) antagonist rescue from complete heart block: pharmacological and genetic evidence for direct S1P3 regulation of mouse cardiac conduction  Academic Article
• Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo d 1,3 dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (jzl184) enhances retrograde endocannabinoid signaling  Academic Article
• Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity  Academic Article
• Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice  Academic Article
• Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain  Academic Article
• Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection  Academic Article
• Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy  Academic Article
• Bone marrow as an alternative site for islet transplantation  Academic Article
• Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection  Academic Article
• Bone marrow-derived HL mitigates bone marrow-derived CETP-mediated decreases in HDL in mice globally deficient in HL and the LDLr  Academic Article
• Bone marrow-derived cells fail to induce positive selection in thymus reaggregation cultures  Academic Article
• Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of hfe, transferrin receptor 2 (tfr2), and il-6  Academic Article
• Boosting immunity to small tumor-associated carbohydrates with bacteriophage Qβ capsids  Academic Article
• Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity  Academic Article
• Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury  Academic Article
• Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice  Academic Article
• Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor  Academic Article
• Breadth of tuning and taste coding in mammalian taste buds  Academic Article
• Break of T cell ignorance to a viral antigen in the liver induces hepatitis  Academic Article
• Bromodomain proteins contribute to maintenance of bloodstream form stage identity in the African trypanosome  Academic Article
• Brown adipogenic reprogramming induced by a small molecule  Academic Article
• CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells  Academic Article
• CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth  Academic Article
• CD4 is expressed on murine pluripotent hematopoietic stem cells  Academic Article
• CD4(+) T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8(+) T-cell immune responses  Academic Article
• CD4+ T cells are required for development of a murine retrovirus-induced immunodeficiency syndrome (MAIDS)  Academic Article
• CD4+ T cells pass through an effector phase during the process of in vivo tolerance induction  Academic Article
• CD40 activation rescues antiviral CD8+ T cells from PD-1-mediated exhaustion  Academic Article
• CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection.  Academic Article
• CD8(+) T-Cell Epitope Mapping for Pneumonia Virus of Mice in H-2(b) Mice  Academic Article
• CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles  Academic Article
• CD8+ memory T cells appear exhausted within hours of acute virus infection  Academic Article
• CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis  Academic Article
• CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells  Academic Article
• CHoMP: a chemoenzymatic histology method using clickable probes  Academic Article
• CTLA-4 blockade enhances the CTL responses to the p53 self-tumor antigen  Academic Article
• CXCL13 is a plasma biomarker of germinal center activity  Academic Article
• Caffeine stimulates cytochrome oxidase expression and activity in the striatum in a sexually dimorphic manner  Academic Article
• Cajal-Retzius cells instruct neuronal migration by coincidence signaling between secreted and contact-dependent guidance cues  Academic Article
• Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts  Academic Article
• Calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3  Academic Article
• Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity  Academic Article
• Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain  Academic Article
• Camkii regulates the frequency-response function of hippocampal synapses for the production of both ltd and ltp  Academic Article
• Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts  Academic Article
• Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: An expanded convergent functional genomics approach  Academic Article
• Cannabinoid CB1 receptors regulate neuronal TNF-alpha effects in experimental autoimmune encephalomyelitis  Academic Article
• Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis  Academic Article
• Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1  Academic Article
• Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles  Academic Article
• Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice  Academic Article
• Catecholamines in mutant mouse cerebellum - fluorescence microscopic and chemical studies  Academic Article
• Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia  Academic Article
• Cc chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: Critical role in migration from the tumor site to draining lymph nodes  Academic Article
• Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue  Academic Article
• Cd14 is required for myd88-independent lps signaling  Academic Article
• Cd2-deficient mice generate virus-specific cytotoxic t-lymphocytes upon infection with lymphocytic choriomeningitis virus  Academic Article
• Cd22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of b cells  Academic Article
• Cd22 regulates adaptive and innate immune responses of b cells  Academic Article
• Cd36 is a sensor of diacylglycerides  Academic Article
• Cd4 t cell control primary measles virus infection of the cns: Regulation is dependent on combined activity with either cd8 t cells or with b cells: Cd4, cd8 or b cells alone are ineffective  Academic Article
• Cd4(+) t cells induced by a DNA vaccine: Immunological consequences of epitope-specific lysosomal targeting  Academic Article
• Cd4-deficient mice have reduced levels of memory cytotoxic t lymphocytes after immunization and show diminished resistance to subsequent virus challenge  Academic Article
• Cd40 ligand-mediated interactions are involved in the generation of memory cd8(+) cytotoxic t lymphocytes (ctl) but are not required for the maintenance of ctl memory following virus infection  Academic Article
• Cd69 down-modulation and inhibition of thymic egress by short- and long-term selective chemical agonism of sphingosine 1-phosphate receptors  Academic Article
• Cd8 t cells are sufficient to mediate allorecognition and allograft rejection  Academic Article
• Cd81 and cd28 costimulate t cells through distinct pathways  Academic Article
• Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway  Academic Article
• Cell and agonist-specific regulation of genes for matrix metalloproteinases and their tissue inhibitors by primary glial cells  Academic Article
• Cell surface 4-1bbl mediates sequential signaling pathways 'downstream' of tlr and is required for sustained tnf production in macrophages  Academic Article
• Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific cd8(+) t cell deletion and viral persistence in vivo  Academic Article
• Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages  Academic Article
• Cellular requirements for antigen presentation in the induction of a thymus-independent antibody response in vitro  Academic Article
• Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome  Academic Article
• Ceramide mediates the rapid phase of febrile response to IL-1β  Academic Article
• Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse  Academic Article
• Changes in striatal signaling induce remodeling of RGS complexes containing G beta 5 and R7BP subunits  Academic Article
• Characteristics of immunity induced by viral antigen or conferred by antibody via different administration routes  Academic Article
• Characterization of GABA- and glycine-induced currents of solitary rodent retinal ganglion cells in culture  Academic Article
• Characterization of TCR gene rearrangements during adult murine T cell development  Academic Article
• Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo  Academic Article
• Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice  Academic Article
• Characterization of kappa opioid receptor mediated, dynorphin-stimulated [(35)S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting  Academic Article
• Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo  Academic Article
• Characterization of mouse mutants with abnormal RPE cells  Academic Article
• Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study  Academic Article
• Characterization of the murine antigenic determinant, designated l3t4a, recognized by monoclonal-antibody gk1.5 - expression of l3t4a by functional t-cell clones appears to correlate primarily with class ii mhc antigen-reactivity  Academic Article
• Characterization of vascular adhesion molecules that may facilitate progenitor homing in the post-natal mouse thymus  Academic Article
• Chemokine expression by intraepithelial gamma delta t cells - implications for the recruitment of inflammatory cells to damaged epithelia  Academic Article
• Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes  Academic Article
• Chimeric molecules created by gene amplification interfere with the analysis of somatic hypermutation of murine immunoglobulin genes  Academic Article
• Chmp5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis  Academic Article
• Chondrogenesis mediated by PPi depletion promotes spontaneous aortic calcification in NPP1-/- mice  Academic Article
• Chromosomal mapping of mouse genes expressed selectively within the central-nervous-system  Academic Article
• Chronic cerebral hypoxia promotes arteriogenic remodeling events that can be identified by reduced endoglin (CD105) expression and a switch in beta 1 integrins  Academic Article
• Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration  Academic Article
• Chronic haloperidol treatment results in a decrease in the expression of myelin/oligodendrocyte-related genes in the mouse brain  Academic Article
• Chronic lymphocytic inflammation specifies the organ tropism of prions  Academic Article
• Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system  Academic Article
• Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone  Academic Article
• Cipc is a mammalian circadian clock protein without invertebrate homologues  Academic Article
• Circadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome  Academic Article
• Circadian timing of ethanol exposure exerts enduring effects on subsequent ad libitum consumption in c57 mice  Academic Article
• Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling  Academic Article
• Citrullination of proteins: A common post-translational modification pathway induced by different nanoparticles in vitro and in vivo  Academic Article
• Class switch recombination and somatic hypermutation in early mouse b cells are mediated by b cell and toll-like receptors  Academic Article
• Class-i mhc can present an endogenous peptide to cyto-toxic lymphocytes-t  Academic Article
• Class-switched memory B cells remodel BCRs within secondary germinal centers  Academic Article
• Clinical features of bacterial vaginosis in a murine model of vaginal infection with Gardnerella vaginalis  Academic Article
• Clonal analysis of autoantibody-producing cell precursors in the preimmune b-cell repertoire  Academic Article
• Clonal analysis of mechanisms of murine t-helper cell collaboration with effector-cells of macrophage lineage  Academic Article
• Cloned cytotoxic T lymphocytes as target cells. II. Polarity of lysis revisited  Academic Article
• Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4  Academic Article
• Cloning and sequencing of cDNA encoding mouse cytohesin-1  Academic Article
• Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein e-deficient mice - demonstration of epitopes of oxidized low density lipoprotein in human plasma  Academic Article
• Clozapine increases apolipoprotein d expression in rodent brain: Towards a mechanism for neuroleptic pharmacotherapy  Academic Article
• Clozapine specifically alters the arachidonic acid pathway in mice lacking apolipoprotein d  Academic Article
• Coding end processing is similar throughout ontogeny  Academic Article
• Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice  Academic Article
• Combination therapy targeting both tumor-initiating and differentiated cell populations in prostate carcinoma  Academic Article
• Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models  Academic Article
• Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of driving robust antitumor immunity  Academic Article
• Commitment to the T-cell receptor-alpha-beta or receptor-gamma-delta lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes  Academic Article
• Common antiviral cytotoxic t-lymphocyte epitope for diverse arenaviruses  Academic Article
• Comparative analysis of antitumor activity of CD40L, RANKL, and 4-1BBL in vivo following intratumoral administration of viral vectors or transduced dendritic cells  Academic Article
• Comparative analysis of dendritic cells transduced with different anti-apoptotic molecules: sensitivity to tumor-induced apoptosis  Academic Article
• Comparative effects of neonatal diethylstilbestrol on external genitalia development in adult males of two mouse strains with differential estrogen sensitivity  Academic Article
• Comparison of anandamide transport in FAAH wild-type and knockout neurons: Evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake  Academic Article
• Comparison of g-protein activation in the brain by mu-, delta-, and kappa-opioid receptor agonists in mu-opioid receptor knockout mice  Academic Article
• Compensatory redistribution of neuroligins and N-cadherin following deletion of synaptic β1-integrin  Academic Article
• Completion of the entire hepatitis C virus life cycle in genetically humanized mice  Academic Article
• Conformational differences in major histocompatibility complex-peptide complexes can result in alloreactivity  Academic Article
• Connections between connexins, calcium, and cataracts in the lens  Academic Article
• Connexin 50 regulates surface ball-and-socket structures and fiber cell organization  Academic Article
• Connexin mediated cataract prevention in mice  Academic Article
• Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo  Academic Article
• Consequences of self-presentation of peptide antigen by cytolytic T lymphocytes  Academic Article
• Conserved amino acid residues in the complementarity-determining region 1 of the TCR β-chain are involved in the recognition of conventional Ag and Mls-1 superantigen  Academic Article
• Consolidation of learning strategies during spatial working memory task requires protein synthesis in the prefrontal cortex  Academic Article
• Contribution of spinal 5-ht1a and 5-ht7 receptors to locomotor-like movement induced by 8-oh-dpat in spinal cord-transected mice  Academic Article
• Contributions of neuronal prion protein on sleep recovery and stress response following sleep deprivation  Academic Article
• Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice  Academic Article
• Control of memory formation through regulated expression of a camkii transgene  Academic Article
• Control of spine maturation and pruning through proBDNF synthesized and released in dendrites  Academic Article
• Convergence of itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation  Academic Article
• Converting IL-15 to a superagonist by binding to soluble IL-15R alpha  Academic Article
• Cooperation of tissue factor cytoplasmic domain and par2 signaling in breast cancer development  Academic Article
• Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment  Academic Article
• Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis  Academic Article
• Coordinated transcription of key pathways in the mouse by the circadian clock  Academic Article
• Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22  Academic Article
• Correction of RT-qPCR data for genomic DNA-derived signals with ValidPrime  Academic Article
• Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development  Academic Article
• Corticotropin-releasing factor receptors CRF1 and CRF2 exert both additive and opposing influences on defensive startle behavior  Academic Article
• Costimulation requirements of induced murine systemic autoimmune disease  Academic Article
• Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection  Academic Article
• Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in c57bl/6j mice  Academic Article
• Covalent linkage of HIV-1 trimers to synthetic liposomes elicits improved B cell and antibody responses  Academic Article
• Coxsackievirus B3 infects the bone marrow and diminishes the restorative capacity of erythroid and lymphoid progenitors  Academic Article
• Coxsackievirus b3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the mhc class i pathway  Academic Article
• Coxsackievirus b3-induced myocarditis - perforin exacerbates disease, but plays no detectable role in virus clearance  Academic Article
• Coxsackievirus can exploit LC3 in both autophagy-dependent and -independent manners in vivo  Academic Article
• Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo  Academic Article
• Coxsackievirus infection of the pancreas: Evaluation of receptor expression, pathogenesis, and immunopathology  Academic Article
• Coxsackievirus preferentially replicates and induces cytopathic effects in undifferentiated neural progenitor cells  Academic Article
• Creb coactivators direct anabolic responses and enhance performance of skeletal muscle  Academic Article
• Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity  Academic Article
• Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus  Academic Article
• Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses  Academic Article
• Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response  Academic Article
• Critical role of transmethylation in TLR signaling and systemic lupus erythematosus  Academic Article
• Cross-linking cellular prion protein triggers neuronal apoptosis in vivo  Academic Article
• Cross-reactivity between hl-a and h-2 antigens. Ii. Allogeneic sensitization by xenogeneic soluble lymphocyte antigens (hl-a)  Academic Article
• Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis  Academic Article
• Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design  Academic Article
• Crystal structure of an mhc class i presented glycopeptide that generates carbohydrate-specific ctl  Academic Article
• Cta1-dd adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization  Academic Article
• Ctl escape viral variants .1. Generation and molecular characterization  Academic Article
• Cultures of astrocytes and microglia express interleukin 18  Academic Article
• Cutting edge: Developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development  Academic Article
• Cutting edge: Early ifn-gamma signaling directly enhances primary antivliwal cd4(+) t cell responses  Academic Article
• Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide  Academic Article
• Cutting edge: Impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein  Academic Article
• Cutting edge: Priming of NK cells by IL-18  Academic Article
• Cutting edge: Recent immune status determines the source of antigens that drive homeostatic t cell expansion  Academic Article
• Cutting edge: dendritic epidermal gamma delta T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding  Academic Article
• Cyclic regulation of sensory perception by a female hormone alters behavior  Academic Article
• Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities  Academic Article
• Cytochrome P450-mediated bioactivation of the epidermal growth factor receptor inhibitor erlotinib to a reactive electrophile  Academic Article
• Cytokine regulation of TNF-alpha mRNA and protein production by unprimed macrophages from C57Bl/6 and NZW mice  Academic Article
• Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition  Academic Article
• Cytoprotective-selective activated protein C therapy for ischaemic stroke  Academic Article
• DISC1 regulates trafficking and processing of APP and Aβ generation  Academic Article
• DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice  Academic Article
• DNA immunization with minigenes: Low frequency of memory cytotoxic t lymphocytes and inefficient antiviral protection are rectified by ubiquitination  Academic Article
• DNA immunization: Ubiquitination of a viral protein enhances cytotoxic t-lymphocyte induction and antiviral protection but abrogates antibody induction  Academic Article
• DNA vaccination against vegf receptor 2 reduces atherosclerosis in ldl receptor-deficient mice  Academic Article
• DNA vaccination with plasmids encoding the intracellular (HBcAg) or secreted (HBeAg) form of the core protein of hepatitis B virus primes T cell responses to two overlapping Kb- and Kd-restricted epitopes  Academic Article
• DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the nkg2d receptor  Academic Article
• Daily scheduled high fat meals moderately entrain behavioral anticipatory activity, body temperature, and hypothalamic c-Fos activation  Academic Article
• Darwinian evolution of prions in cell culture  Academic Article
• Decay-accelerating factor 1 (daf1) deficiency exacerbates xenobiotic-induced autoimmunity  Academic Article
• Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice  Academic Article
• Decreased brain reward function during nicotine withdrawal in c57bl6 mice: Evidence from intracranial self-stimulation (icss) studies  Academic Article
• Decreased immobility in swimming test by homologous interferon-alpha in mice accompanied with increased cerebral tryptophan level and serotonin turnover  Academic Article
• Decreased phospho-Akt signaling in a mouse model of total parenteral nutrition: a potential mechanism for the development of intestinal mucosal atrophy  Academic Article
• Deep proteome mapping of mouse kidney based on OFFGel prefractionation reveals remarkable protein post- translational modifications  Academic Article
• Deep sequencing of the murine Igh repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies  Academic Article
• Deep sequencing reveals cell-type-specific patterns of single-cell transcriptome variation  Academic Article
• Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders  Academic Article
• Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene  Academic Article
• Defective lymphotoxin-β receptor-induced NF-κB transcriptional activity in NIK-deficient mice  Academic Article
• Defects in skin γδ T cell function contribute to delayed wound repair in rapamycin-treated mice  Academic Article
• Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist  Academic Article
• Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy  Academic Article
• Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis  Academic Article
• Defining parameters for successful immunocytotherapy of persistent viral infection  Academic Article
• Defining the conformational features of anchorless, poorly neuroinvasive prions  Academic Article
• Defining the critical hypoxic threshold that promotes vascular remodeling in the brain  Academic Article
• Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity  Academic Article
• Delayed and accelerated aging share common longevity assurance mechanisms  Academic Article
• Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice  Academic Article
• Deletion of PREPl causes growth impairment and hypotonia in mice  Academic Article
• Deletion of ghrelin impairs neither growth nor appetite  Academic Article
• Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus  Academic Article
• Deletion of p21 (WAF-1/Cip1) does not induce systemic autoimmunity in female BXSB mice  Academic Article
• Deletion of the nucleotide excision repair gene ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions  Academic Article
• Deletions within the 5 ' utr of coxsackievirus b3: Consequences for virus translation and replication  Academic Article
• Delineation of spontaneous erythrocyte autoantibody responses of nzb and other strains of mice  Academic Article
• Delta-9,11 modification of glucocorticoids dissociates nuclear factor-κB inhibitory efficacy from glucocorticoid response element-associated side effects  Academic Article
• Demonstration of developmental anomalies in mouse fetuses by transfer of murine cytomegalovirus DNA-injected eggs to surrogate mothers  Academic Article
• Dendritic BDNF synthesis is required for late-phase spine maturation and recovery of cortical responses following sensory deprivation  Academic Article
• Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation  Academic Article
• Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice  Academic Article
• Dendritic cell-based genetic immunization in mice with a recombinant adenovirus encoding murine TRP2 induces effective anti-melanoma immunity  Academic Article
• Dendritic cell-secreted cytotoxic T-lymphocyte-associated protein-4 regulates the T-cell response by downmodulating bystander surface B7  Academic Article
• Dendritic cells genetically engineered to express IL-4 exhibit enhanced IL-12p70 production in response to CD40 ligation and accelerate organ allograft rejection  Academic Article
• Dendritic epidermal T cells regulate skin antimicrobial barrier function  Academic Article
• Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1  Academic Article
• Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin  Academic Article
• Dense nuclear cataract caused by the γB-crystallin S11R point mutation  Academic Article
• Dependence-induced increases in ethanol self-administration in mice are blocked by the crf, receptor antagonist antalarmin and by crf, receptor knockout  Academic Article
• Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes  Academic Article
• Deregulated cyclin E promotes p53 loss of heterozygosity and tumorigenesis in the mouse mammary gland  Academic Article
• Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes  Academic Article
• Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor  Academic Article
• Design, synthesis and SAR of novel glucokinase activators  Academic Article
• Design, synthesis, and characterization of alpha-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase  Academic Article
• Detection of h-2 antigens in serum  Academic Article
• Detection of low-avidity CD4(+) T cells using recombinant artificial APC: following the antiovalbumin immune response  Academic Article
• Determination of key aspects of precursor cell proliferation, cell cycle length and kinetics in the adult mouse subgranular zone  Academic Article
• Development and maintenance of a b220(-) memory b cell compartment  Academic Article
• Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens  Academic Article
• Development of ecdysone-regulated lentiviral vectors  Academic Article
• Development of functionally selective, small molecule agonists at kappa opioid receptors  Academic Article
• Development of immature thymocytes - initiation of CD3, CD4, and CD8 acquisition parallels down-regulation of the interleukin-2 receptor alpha-chain  Academic Article
• Development of lupus in BXSB mice is independent of IL-4  Academic Article
• Developmental expression of the alpha(iel)beta(7) integrin on t-cell receptor-gamma-delta and t-cell receptor-alpha-beta t-cells  Academic Article
• Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease  Academic Article
• Developmental regulation of beta 1 integrins during angiogenesis in the central nervous system  Academic Article
• Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1  Academic Article
• Didehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic mice  Academic Article
• Diet and feeding pattern affect the diurnal dynamics of the gut microbiome  Academic Article
• Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or-4 receptors  Academic Article
• Differences in the degree of depletion, rate of recovery, and the preferential elimination of naive cd4(+) t-cells by anti-cd4 monoclonal-antibody (gk1.5) in young and aged mice  Academic Article
• Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice  Academic Article
• Differences in the liability to self-administer intravenous cocaine between c57bl/6xsjl and balb/cbyj mice  Academic Article
• Different mechanisms of increased luminal stenosis after arterial injury in mice deficient for urokinase- or tissue-type plasminogen activator  Academic Article
• Differential T cell responses to residual viral antigen prolong CD4(+) T cell contraction following the resolution of infection  Academic Article
• Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively  Academic Article
• Differential dynamics of the peripheral and intrahepatic cytotoxic T lymphocyte response to hepatitis B surface antigen  Academic Article
• Differential effects of a new amphotericin B derivative, MS-8209, on mouse BSE and scrapie: Implications for the mechanism of action of polyene antibiotics  Academic Article
• Differential effects of il-12 on the generation of alloreactive ctl mediated by murine and human dendritic cells: A critical role for nitric oxide  Academic Article
• Differential expression of 2 distinct xenotropic viruses in nzb mice  Academic Article
• Differential gene expression in lps/ifn gamma activated microglia and macrophages: In vitro versus in vivo  Academic Article
• Differential gene expression in the developing lateral geniculate nucleus and medial geniculate nucleus reveals novel roles for Zic4 and Foxp2 in visual and auditory pathway development  Academic Article
• Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation  Academic Article
• Differential regulation of antiviral T-cell immunity results in stable CD8(+) but declining CD4(+) T-cell memory  Academic Article
• Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation  Academic Article
• Differential regulation of vitronectin in mice and humans in vitro  Academic Article
• Differential role of melanocortin receptor subtypes in cachexia  Academic Article
• Differentiation and histological analysis of embryonic stem cell-derived neural transplants in mice  Academic Article
• Differentiation of mouse keratinocytes is accompanied by pkc-dependent changes in ap-1 proteins  Academic Article
• Direct comparison of Dll1-and Dll4-mediated notch activation levels shows differential lymphomyeloid lineage commitment outcomes  Academic Article
• Direct reactivation of a coherent neocortical memory of context  Academic Article
• Discovery and characterization of an endogenous CXCR4 antagonist  Academic Article
• Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia  Academic Article
• Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors  Academic Article
• Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia  Academic Article
• Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer  Academic Article
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• Discovery of a proneurogenic, neuroprotective chemical  Academic Article
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• Disruption of myd88 signaling suppresses hemophagocytic lymphohistiocytosis in mice  Academic Article
• Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal  Academic Article
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• Disruption of the plasminogen activator inhibitor-1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice  Academic Article
• Dissociation of analgesic and hormonal responses to forced swim stress using opioid receptor knockout mice  Academic Article
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• Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice  Academic Article
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• ENU-induced phenovariance in mice: Inferences from 587 mutations  Academic Article
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• EPHA2 is associated with age-related cortical cataract in mice and humans  Academic Article
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• Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice  Academic Article
• Effect of hyperhomocysteinemia on protein C activation and activity  Academic Article
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• Effective eradication of established murine tumors with IL-12 gene-therapy using a polycistronic retroviral vector  Academic Article
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• Effective therapy of the LP-BM5 murine retrovirus-induced lymphoproliferative immunodeficiency disease with diethyldithiocarbamate  Academic Article
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• Effects of chronic overexpression of interleukin-1 receptor antagonist in a model of permanent focal cerebral ischemia in mouse  Academic Article
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• Effects of soluble TNF receptor treatment on lipopolysaccharide-induced myocardial cytokine expression  Academic Article
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• Endotoxin stimulates expression of the murine urokinase receptor gene in vivo  Academic Article
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• Enforced bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral b cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature b cells  Academic Article
• Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease  Academic Article
• Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease  Academic Article
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• Envelope exchange for the generation of live-attenuated arenavirus vaccines  Academic Article
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• EphA2 and ephrin-A5 are not a receptor-ligand pair in the ocular lens  Academic Article
• Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation  Academic Article
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• Evaluation of quinacrine treatment for prion diseases  Academic Article
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• Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus  Academic Article
• Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death  Academic Article
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• Exosomes derived from genetically modified dc expressing fasl are anti-inflammatory and immunosuppressive  Academic Article
• Exosomes released by islet-derived mesenchymal stem cells trigger autoimmune responses in NOD mice  Academic Article
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• Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor  Academic Article
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• Expression of GABA(C) receptor rho 1 and rho 2 subunits during development of the mouse retina  Academic Article
• Expression of an adenovirally encoded lymphotoxin-beta inhibitor prevents clearance of Listeria monocytogenes in mice  Academic Article
• Expression of cytotactin in the normal and regenerating neuromuscular system  Academic Article
• Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage  Academic Article
• Expression of selected antigens on surface of cultured neural cells  Academic Article
• Expression of t-cell receptor genes in an antigen-specific hybridoma and radiation-induced variants  Academic Article
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• Extensive vascular remodeling in the spinal cord of pre-symptomatic experimental autoimmune encephalomyelitis mice; increased vessel expression of fibronectin and the alpha 5 beta 1 integrin  Academic Article
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• Extracellular processing of peptide antigens that bind class I major histocompatibility molecules  Academic Article
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• FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration  Academic Article
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• Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice  Academic Article
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• Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge  Academic Article
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• Genetic analysis of the corticosterone response to ethanol in bxd recombinant inbred mice  Academic Article
• Genetic and physical mapping of the Lps locus: Identification of the Toll-4 receptor as a candidate gene in the critical region  Academic Article
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• Genetic differences in behavioral sensitivity to a neuroactive steroid  Academic Article
• Genetic differences in hypothalamic-pituitary-adrenal axis responsiveness to acute ethanol and acute ethanol withdrawal  Academic Article
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• Genetic diversity of murine rheumatoid factors  Academic Article
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• Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes  Academic Article
• Genetic loss of FAAH compromises male fertility in mice  Academic Article
• Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling  Academic Article
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• Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). II. Qualitative characteristics of the humoral immune response to the a, d, and y determinants of HBsAg  Academic Article
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• Loss of nicotine-induced behavioral sensitization in mu-opioid receptor knockout mice  Academic Article
• Loss of sex discrimination and male-male aggression in mice deficient for trp2  Academic Article
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• Ly phenotype and mechanism of action of mouse neonatal suppressor T cells  Academic Article
• Lyb-7, a new B cell alloantigen controlled by genes linked to the IgCH locus  Academic Article
• Lymphocyte-mediated alopecia in c57bl/6 mice following successful immunotherapy for melanoma  Academic Article
• Lymphoid reservoirs of antigen-specific memory t helper cells  Academic Article
• Lymphoproliferative disease and autoimmunity in mice with increased mir-17-92 expression in lymphocytes  Academic Article
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• Manipulation of Panx1 activity increases the engraftment of transplanted lacrimal gland epithelial progenitor cells  Academic Article
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• Mapping murine loci for seizure response to kainic acid  Academic Article
• Mapping of epitopes recognized by alloreactive cytotoxic T lymphocytes using inhibition by MHC peptides  Academic Article
• Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain  Academic Article
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• Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk  Academic Article
• Maternal b lymphocytes specific for paternal histocompatibility antigens are partially deleted during pregnancy  Academic Article
• Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity  Academic Article
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• Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia  Academic Article
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• Mutability of prions  Academic Article
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• Pharmacological and behavioral profile of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-chinolincarboxamide (EVP-5141), a novel α7 nicotinic acetylcholine receptor agonist/serotonin 5-HT3 receptor antagonist  Academic Article
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• Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A)  Academic Article
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• Pharmacological studies of a new derivative of amphotericin-B, MS-8209, in mouse and hamster scrapie  Academic Article
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• Plasma cells negatively regulate the follicular helper t cell program  Academic Article
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• Plasminogen has a broad extrahepatic distributions  Academic Article
• Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite  Academic Article
• Platelet glycoprotein Ib alpha supports experimental lung metastasis  Academic Article
• Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia  Academic Article
• Platelet, not endothelial, p-selectin is required for neointimal formation after vascular injury  Academic Article
• Platelets adhere to and translocate on von Willebrand factor presented by endothelium in simulated veins  Academic Article
• Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage  Academic Article
• Platelets mediate cytotoxic T lymphocyte-induced liver damage  Academic Article
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• Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains  Academic Article
• Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence  Academic Article
• Point mutations in the melanocortin-4 receptor cause variable obesity in mice  Academic Article
• Polyclonality and multispecificity of the CTL response to a single viral epitope  Academic Article
• Polymorphism within a tcrav family influences the repertoire through class i/ii restriction  Academic Article
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• Positive regulation of ltk ph domain function by soluble ip(4)  Academic Article
• Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties  Academic Article
• Posttranscriptional clearance of hepatitis B virus RNA by cytotoxic T lymphocyte-activated hepatocytes  Academic Article
• Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase large is critical for virus binding  Academic Article
• Posttranslational regulation of tcr v alpha allelic exclusion during t cell differentiation  Academic Article
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• Potential role for padi-mediated histone citrullination in preimplantation development  Academic Article
• Preclinical evaluation of an anti-HCV miRNA cluster for treatment of HCV infection  Academic Article
• Preclinical metabolic changes in mouse prion diseases detected by 1H-nuclear magnetic resonance spectroscopy  Academic Article
• Precursor frequency, nonlinear proliferation, and functional maturation of virus-specific CD4(+) T cells  Academic Article
• Precursor thymocyte proliferation and differentiation are controlled by signals unrelated to the pre-TCR  Academic Article
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• Prenatal diethylstilbestrol induces malformation of the external genitalia of male and female mice and persistent second-generation developmental abnormalities of the external genitalia in two mouse strains  Academic Article
• Preparation of functionally active [35S] leptin for mapping its receptors in the brain  Academic Article
• Presynaptic crf(1) receptors mediate the ethanol enhancement of gabaergic transmission in the mouse central amygdala  Academic Article
• Presynaptic delta opioid receptors regulate ethanol actions in central amygdala  Academic Article
• Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model  Academic Article
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• Primary demyelination in transgenic mice expressing interferon-gamma  Academic Article
• Primary in vitro antibody responses by purified murine B lymphocytes in serum-free defined medium  Academic Article
• Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury  Academic Article
• Principles of cytotoxic T lymphocyte induction and recognition  Academic Article
• Prion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assay  Academic Article
• Prion strain discrimination in cell culture: The cell panel assay  Academic Article
• Prion strain discrimination using luminescent conjugated polymers  Academic Article
• Prion transmission prevented by modifying the beta 2-alpha 2 loop structure of host PrP(C)  Academic Article
• Prion-induced amyloid heart disease with high blood infectivity in transgenic mice  Academic Article
• Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database  Academic Article
• Progesterone receptor-mediated up-regulation of transthyretin in preimplantation mouse uterus  Academic Article
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• Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer  Academic Article
• Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury  Academic Article
• Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice  Academic Article
• Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic-cells transduced with a retrovirus carrying the hIL-1ra cDNA  Academic Article
• Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation  Academic Article
• Propagation of rml prions in mice expressing prp devoid of gpi anchor leads to formation of a novel, stable prion strain  Academic Article
• Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with notch receptor ligation  Academic Article
• Protease-activated receptor (par) 2, but not par1, signaling promotes the development of mammary adenocarcinoma in polyoma middle t mice  Academic Article
• Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity  Academic Article
• Protease-activated receptor-1 signaling by activated protein c in cytokine-perturbed endothelial cells is distinct from thrombin signaling  Academic Article
• Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in ldl receptor-deficient mice  Academic Article
• Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy  Academic Article
• Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid  Academic Article
• Protection of the intestinal mucosa by intraepithelial gamma delta T cells  Academic Article
• Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1  Academic Article
• Protective immunity against human carcinoembryonic antigen (cea) induced by an oral DNA vaccine in cea-transgenic mice  Academic Article
• Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation  Academic Article
• Protein 4.1B suppresses prostate cancer progression and metastasis  Academic Article
• Protein S confers neuronal protection during ischemic/hypoxic injury in mice  Academic Article
• Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity  Academic Article
• Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region  Academic Article
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• Protein kinase C η is required for T cell activation and homeostatic proliferation  Academic Article
• Protein kinase C-eta controls CTLA-4-mediated regulatory T cell function  Academic Article
• Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation  Academic Article
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• Prp expression in b lymphocytes is not required for prion neuroinvasion  Academic Article
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• Quantitative trait loci mapping for cholesterol gallstones in akr/j and c57l/j strains of mice  Academic Article
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• RGS6/G beta 5 complex accelerates IKaCh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate  Academic Article
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• Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization  Academic Article
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• Reactivity of steroid-resistant neonatal thymocytes  Academic Article
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• Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival  Academic Article
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• Role of leukocyte-specific ldl receptors on plasma lipoprotein cholesterol and atherosclerosis in mice  Academic Article
• Role of par2 in murine pulmonary pseudomonal infection  Academic Article
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• Ror alpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways  Academic Article
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• S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells  Academic Article
• S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species  Academic Article
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• SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells  Academic Article
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• Selection against puma gene expression in myc-driven b-cell lymphomagenesis  Academic Article
• Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice  Academic Article
• Selection of tcr v-alpha by mhc class-ii predicts superantigen reactivity  Academic Article
• Selective N-hydroxyhydantoin carbamate inhibitors of mammalian serine hydrolases  Academic Article
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• Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice  Academic Article
• Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, lPB3/EDG-3  Academic Article
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• Sequence and fine specificity analysis of primary 511 anti-phosphorylcholine antibodies  Academic Article
• Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in Fragile X-associated tremor/ataxia syndrome  Academic Article
• Serial backcross mapping of multiple loci associated with resistance to leishmania major in mice  Academic Article
• Serine hydrolase KIAA1363: Toxicological and structural features with emphasis on organophosphate interactions  Academic Article
• Serotonin reciprocally regulates melanocortin neurons to modulate food intake  Academic Article
• Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a beta-arrestin2/Src/Akt signaling complex in vivo  Academic Article
• Serum- and glucocorticoid-inducible kinase 1 confers protection in cell-based and in in vivo neurotoxin models via the c-Jun N-terminal kinase signaling pathway  Academic Article
• Severe microcytic anemia but increased erythropoiesis in mice lacking hfe or tfr2 and tmprss6  Academic Article
• Severe retinal degeneration caused by a novel rhodopsin mutation  Academic Article
• Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice  Academic Article
• Sex- and age-specific differences in core body temperature of C57Bl/6 mice  Academic Article
• Sexual cell-fate reprogramming in the ovary by DMRT1  Academic Article
• Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages  Academic Article
• Shift from systemic to site-specific memory by tumor-targeted il-2  Academic Article
• Short-term fasting induces profound neuronal autophagy  Academic Article
• Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger  Academic Article
• Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1 gamma, MIP2, MIP3 alpha, and IL12 (p40/p70) by retinal Muller glial cells  Academic Article
• Sigma receptor 1 modulates ER stress and Bcl2 in murine retina  Academic Article
• Sigma(1) receptor-related neuroactive steroids modulate cocaine-induced reward  Academic Article
• Sigma-1 receptor knockout mice display a depressive-like phenotype  Academic Article
• Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma  Academic Article
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• Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway  Academic Article
• Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing  Academic Article
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• Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection  Academic Article
• Small animal models for acquired immune deficiency syndrome (AIDS) research  Academic Article
• Social behavioral deficits coincide with the onset of seizure susceptibility in mice lacking serotonin receptor 2c  Academic Article
• Sod2 deficient erythroid cells up-regulate transferrin receptor and down-regulate mitochondrial biogenesis and metabolism  Academic Article
• Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2  Academic Article
• Soluble cd14-mediated cellular responses to lipopolysaccharide  Academic Article
• Soluble transferrin receptor-1 levels in mice do not affect iron absorption  Academic Article
• Spatial mapping of thymic stromal microenvironments reveals unique features influencing T lymphoid differentiation  Academic Article
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• Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity  Academic Article
• Species-specific anticoagulant and mitogenic activities of murine protein S  Academic Article
• Specific H chain junctional diversity may be required for non-T15 antibodies to bind phosphorylcholine  Academic Article
• Specific antigen-binding and antibody-secreting lymphocytes associated with erythrocyte autoantibody responses of nzb and genetically unrelated mice  Academic Article
• Specificity of in vitro cyto-toxic t-cell clones directed against vesicular stomatitis-virus  Academic Article
• Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival  Academic Article
• Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate  Academic Article
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• Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2  Academic Article
• Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated cd4(+) t cells  Academic Article
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• Spinal 5-ht(7) receptors are critical for alternating activity during locomotion: In vitro neonatal and in vivo adult studies using 5-ht(7) receptor knockout mice  Academic Article
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• Split tolerance in peripheral B cell subsets in mice expressing a low level of Ig kappa-reactive ligand  Academic Article
• Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice  Academic Article
• Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR  Academic Article
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• Strain-specific role of RNAs in prion replication  Academic Article
• Stromal cells provide the matrix for migration of early lymphoid progenitors through the thymic cortex  Academic Article
• Structural and functional identification of major histocompatibility complex class i-restricted self-peptides as naturally occurring molecular mimics of viral antigens - possible role in cd8(+) t cell-mediated, virus-induced autoimmune disease  Academic Article
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• Structure-based design and synthesis of a small molecule that exhibits anti-inflammatory activity by inhibition of MyD88-mediated signaling to bacterial toxin exposure  Academic Article
• Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells  Academic Article
• Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus  Academic Article
• Subcellular targeting and differential s-nitrosylation of endothelial nitric-oxide synthase  Academic Article
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• Successful treatment of the murine model of cystinosis using bone marrow cell transplantation  Academic Article
• Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin  Academic Article
• Suppression of Fcγ-receptor-mediated antibody effector function during persistent viral infection  Academic Article
• Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand  Academic Article
• Suppression of atherosclerosis by synthetic REV-ERB agonist  Academic Article
• Suppression of colitis in mice by cl-amidine: A novel peptidylarginine deiminase inhibitor  Academic Article
• Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus  Academic Article
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• T cell development in mice expressing CD1d directed by a classical MHC class II promoter  Academic Article
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• Tcr affinity and negative regulation limit autoimmunity  Academic Article
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• The 4S polycyclic aromatic hydrocarbon-binding protein: immunohistochemical localization in mice  Academic Article
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• The 5-HT(7) receptor is involved in allocentric spatial memory information processing  Academic Article
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• The E3 ubiquitin ligase itch couples JNK activation to TNF alpha-induced cell death by inducing c-FLIP(L) turnover  Academic Article
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• The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice  Academic Article
• The M22 antibody identifies highly activated reactive astrocytes responding to central nervous system disease  Academic Article
• The Mohawk homeobox gene is a critical regulator of tendon differentiation  Academic Article
• The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable Haemophilus influenzae from the mouse lung  Academic Article
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• The contribution of various NOS gene products to HIV-1 coat protein (gp120)-mediated retinal ganglion cell injury  Academic Article
• The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr  Academic Article
• The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice  Academic Article
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• The deoxyribonucleic acid repair protein flap endonuclease-1 modulates estrogen-responsive gene expression  Academic Article
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• The dynamics of T cell-dependent B cell responses in vivo  Academic Article
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• The endogenous cannabinoid system protects against colonic inflammation  Academic Article
• The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus  Academic Article
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• The induction of cytolytic T lymphocytes with purified plasma membranes  Academic Article
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• The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gamma delta T cell activation  Academic Article
• The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15  Academic Article
• The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak  Academic Article
• The lysophosphatidic acid receptor lpa(1) promotes epithelial cell apoptosis after lung injury  Academic Article
• The mGluR5 antagonist MPEP suppresses the expression and reinstatement, but not the acquisition, of the ethanol-conditioned place preference in mice  Academic Article
• The major histocompatibility complex requirement for cellular collaboration in the murine lymphoid procoagulant response stimulated by bacterial lipopolysaccharide  Academic Article
• The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis  Academic Article
• The melanocortin-3 receptor is required for entrainment to meal intake  Academic Article
• The methylenetetrahydrofolate reductase (Mthfr) gene maps to distal mouse chromosome 4  Academic Article
• The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model  Academic Article
• The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families  Academic Article
• The mouse lP(A3)/Edg7 lysophosphatidic acid receptor gene: Genomic structure, chromosomal localization, and expression pattern  Academic Article
• The mouse supt16h/fact140 gene, encoding part of the fact chromatin transcription complex, maps close to tcra and is highly expressed in thymus  Academic Article
• The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal  Academic Article
• The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents  Academic Article
• The ontogeny of thymic independent antibody responses in vitro in normal mice and mice with an X-linked B cell defect  Academic Article
• The opioid peptides enkephalin and beta-endorphin in alcohol dependence  Academic Article
• The origin and function of soluble cd14 in experimental bacterial meningitis  Academic Article
• The origin of strain-specific differences in the specificity repertoires of murine cytolytic T lymphocytes  Academic Article
• The phospholipase A(2) inhibitor methyl indoxam suppresses diet-induced obesity and glucose intolerance in mice  Academic Article
• The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity  Academic Article
• The potential dual effects of anesthetic isoflurane on Aβ-induced apoptosis  Academic Article
• The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice  Academic Article
• The proliferative potential of hematopoietic stem cells (CFUs) during serial passage in irradiated mice as foci of ectopic hematopoiesis [Article in Russian]  Academic Article
• The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance  Academic Article
• The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases  Academic Article
• The rapidity with which virus-specific CD8+ T cells initiate IFN-γ synthesis increases markedly over the course of infection and correlates with immunodominance  Academic Article
• The recognition of H-2 and viral antigens by cytotoxic T cells  Academic Article
• The regulation of retina specific expression of rhodopsin gene in vertebrates  Academic Article
• The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins  Academic Article
• The role of IFN regulatory factor-1 in synovitis and nitric oxide production  Academic Article
• The role of IFN-gamma in the production of Th2 subpopulations: implications for variable Th2-mediated pathologies in autoimmunity  Academic Article
• The role of alpha beta(+) T cells and homeostatic T cell proliferation in Y-chromosome-associated murine lupus  Academic Article
• The role of b lymphocytes in coxsackievirus b3 infection  Academic Article
• The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB  Academic Article
• The role of cd8(+) t-lymphocytes in coxsackievirus b3-induced myocarditis  Academic Article
• The role of surface IgD in the response to thymic-independent antigens  Academic Article
• The role of vldlr in intraretinal angiogenesis in mice  Academic Article
• The search for Lps: 1993-1998  Academic Article
• The selective monoacylglycerol lipase inhibitor MJN110 produces opioid-sparing effects in a mouse neuropathic pain model  Academic Article
• The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome  Academic Article
• The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors  Academic Article
• The sorting receptor SorCS1 regulates trafficking of neurexin and AMPA receptors  Academic Article
• The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing  Academic Article
• The sphingosine-1-phosphate (S1P) lysophospholipid receptor S1P3 regulates MAdCAM-1+ endothelial cells in splenic marginal sinus organization  Academic Article
• The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice  Academic Article
• The temporal expression patterns of fibronectin and its receptors-α5β1 and αvβ3 integrins on blood vessels after cerebral ischemia  Academic Article
• The tissue factor pathway mediates both activation of coagulation and coagulopathy after injury  Academic Article
• The tpl2 mutation sluggish impairs type i ifn production and increases susceptibility to group b streptococcal disease  Academic Article
• The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells  Academic Article
• The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance  Academic Article
• The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs  Academic Article
• The tropomodulin (Tmod) gene maps to chromosome 4, closely linked to Mup1  Academic Article
• The tyrosine kinase inhibitor gefitinib restricts mycobacterium tuberculosis growth through increased lysosomal biogenesis and modulation of cytokine signaling  Academic Article
• The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis  Academic Article
• The unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via toll-like receptors 3, 7 and 9  Academic Article
• The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α /ATF6α complex  Academic Article
• The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire  Academic Article
• The use of small molecule probes to study spatially separated stimulus-induced signaling pathways  Academic Article
• The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs  Academic Article
• Themis sets the signal threshold for positive and negative selection in T-cell development  Academic Article
• Therapeutic and specific antitumor immunity induced by co-administration of immature dendritic cells and adenoviral vector expressing biologically active IL-18  Academic Article
• Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models  Academic Article
• Therapeutic efficacy of tumor-targeted il2 in lt alpha(-/-) mice depends on conditioned t cells  Academic Article
• Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease  Academic Article
• Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4  Academic Article
• Thymic cortical epithelium is sufficient for the development of mature t cells in relb-deficient mice  Academic Article
• Thymic selection and adaptability of cytotoxic t-lymphocyte responses in transgenic mice expressing a viral protein in the thymus  Academic Article
• Thymic selection and cell-division  Academic Article
• Thymic selection by a single mhc/peptide ligand produces a semidiverse repertoire of cd4(+) t cells  Academic Article
• Thymic selection by a single mhc/peptide ligand: Autoreactive t cells are low-affinity cells  Academic Article
• Thymic skewing of the cd4/cd8 ratio maps with the t-cell receptor alpha-chain locus  Academic Article
• Thymic t cell development and progenitor localization depend on ccr7  Academic Article
• Thymocyte expression of cathepsin L is essential for NKT cell development  Academic Article
• Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to "holes" in the t cell repertoire  Academic Article
• Thymocyte stimulation by anti-tcr-beta, but not by anti-tcr-alpha, leads to induction of developmental transcription program  Academic Article
• Tid1 is required for T cell transition from double-negative 3 to double-positive stages  Academic Article
• Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor 1(2)tid, is critical for early embryonic development and cell survival  Academic Article
• Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons  Academic Article
• Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression  Academic Article
• Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges  Academic Article
• Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet  Academic Article
• Tissue distribution and regulation of murine von Willebrand factor gene expression in vivo  Academic Article
• Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice  Academic Article
• Tissue distribution of factor VIII gene expression in vivo: a closer look  Academic Article
• Tissue factor expression during human and mouse development  Academic Article
• Tissue factor gene expression in the adipose tissues of obese mice  Academic Article
• Tissue factor prothrombotic activity is regulated by integrin-arf6 trafficking  Academic Article
• Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation  Academic Article
• Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage  Academic Article
• Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model - studies in tPA-deficient mice and wild-type mice on a matched genetic background  Academic Article
• Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice  Academic Article
• Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C  Academic Article
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• Tissue-specific regulation of p38α-mediated inflammation in Con A-induced acute liver damage  Academic Article
• Tlr2 is constitutively expressed within the kidney and participates in ischemic renal injury through both myd88-dependent and -independent pathways  Academic Article
• Tlr2 signaling subpathways regulate tlr9 signaling for the effective induction of il-12 upon stimulation by heat-killed brucella abortus  Academic Article
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• Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection  Academic Article
• Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection  Academic Article
• Toll-like receptors in atherosclerosis  Academic Article
• Topical treatment of basal cell carcinomas in nevoid basal cell carcinoma syndrome with a Smoothened inhibitor  Academic Article
• Topically applied human recombinant monoclonal igg(1) antibody and its fab and f(ab')(2) fragments protect mice from vaginal transmission of hsv-2  Academic Article
• Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon  Academic Article
• Towards understanding the schizophrenia code: an expanded convergent functional genomics approach  Academic Article
• Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease  Academic Article
• Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells  Academic Article
• Transcriptional code and disease map for adult retinal cell types  Academic Article
• Transcriptional control of preadipocyte determination by Zfp423  Academic Article
• Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing  Academic Article
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• Transduction of dendritic cells with Bcl-xL increases their resistance to prostate cancer-induced apoptosis and antitumor effect in mice  Academic Article
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• Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism  Academic Article
• Transgene-driven expression of the doppel protein in purkinje cells causes purkinje cell degeneration and motor impairment  Academic Article
• Transgenic calmodulin-dependent protein kinase ii activation: Dose-dependent effects on synaptic plasticity, learning, and memory  Academic Article
• Transgenic mice expressing human hla and cd8 molecules generate hla-restricted measles virus cytotoxic t lymphocytes of the same specificity as humans with natural measles virus infection  Academic Article
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• Transgenic overexpression of interleukin-1 receptor antagonist in the CNS influences behaviour, serum corticosterone and brain monoamines  Academic Article
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• Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy  Academic Article
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• Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice  Academic Article
• Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection  Academic Article
• Trif is not required for immune complex glomerulonephritis: Dying cells activate mesangial cells via tlr2/myd88 rather than tlr3/trif  Academic Article
• Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state  Academic Article
• TrkB receptor controls striatal formation by regulating the number of newborn striatal neurons  Academic Article
• Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle  Academic Article
• Tumor necrosis factor alpha and interleukin 1 alpha induce anchorage independence in v-jun transgenic murine cells  Academic Article
• Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease  Academic Article
• Tumor-necrosis-factor-alpha and interleukin-1-alpha enhance glucose-utilization by astrocytes - involvement of phospholipase a(2)  Academic Article
• Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses  Academic Article
• Two distinct but overlapping antibody binding sites in the pre-S(2) region of HBsAg localized within 11 continuous residues  Academic Article
• Two subsets of epithelial cells in the thymic medulla  Academic Article
• Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury  Academic Article
• Type 1 plasminogen activator inhibitor gene expression following partial hepatectomy  Academic Article
• Type C botulinum toxin causes degeneration of motoneurons in vivo  Academic Article
• Type I and type II interferon coordinately regulate suppressive dendritic cell fate and function during viral persistence  Academic Article
• Type I interferon is a therapeutic target for virus-induced lethal vascular damage  Academic Article
• Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection  Academic Article
• UNC93B1 mediates host resistance to infection with Toxoplasma gondii  Academic Article
• Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production  Academic Article
• Ultrastructural localization of cellular prion protein (prpc) at the neuromuscular junction  Academic Article
• Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice  Academic Article
• Unc93b1 biases toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against rna-sensing  Academic Article
• Unexpected autoantibody production in membrane ig-mu-deficient/lpr mice  Academic Article
• Unifying model for molecular determinants of the preselection Vβ repertoire  Academic Article
• Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents  Academic Article
• Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model  Academic Article
• Unique uterine localization and regulation may differentiate LPA3 from other lysophospholipid receptors for its role in embryo implantation  Academic Article
• Unrestricted recognition of a nonpeptide antigen by CD8+ cytolytic T lymphocytes  Academic Article
• Up-regulation of surface-markers on dying thymocytes  Academic Article
• Upregulation of fibronectin and the α5β1 and αvβ3 integrins on blood vessels within the cerebral ischemic penumbra  Academic Article
• Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis  Academic Article
• Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior  Academic Article
• Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm  Academic Article
• Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse  Academic Article
• Use of a high-affinity peptide that aborts mhc-restricted cytotoxic t lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo  Academic Article
• Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling  Academic Article
• Using injectoporation to deliver genes to mechanosensory hair cells  Academic Article
• Using recombinant coxsackievirus b3 to evaluate the induction and protective efficacy of cd8(+) t cells during picornavirus infection  Academic Article
• V alpha 3.2 selection in mhc class i mutant mice - evidence for an alternate orientation of tcr-mhc class i interaction  Academic Article
• V-beta gene repertoires in t-cells expanded in local self-healing and lethal systemic murine cutaneous leishmaniasis  Academic Article
• VBP15, a novel anti-inflammatory, is effective at reducing the severity of murine experimental autoimmune encephalomyelitis  Academic Article
• VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses  Academic Article
• VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation  Academic Article
• Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope  Academic Article
• Vaccination protects beta(2) microglobulin deficient mice from immune mediated mortality but not from persisting viral infection  Academic Article
• Vascular endothelial growth factor receptor 2-based DNA immunization delays development of herpetic stromal keratitis by antiangiogenic effects  Academic Article
• Velvet, a dominant egfr mutation that causes wavy hair and defective eyelid development in mice  Academic Article
• Versatile strategy for controlling the specificity and activity of engineered T cells  Academic Article
• Vesicular stomatitis virus glycoprotein g activates a specific antiviral toll-like receptor 4-dependent pathway  Academic Article
• Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein  Academic Article
• Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: Evidence for involvement of genetically modified dendritic cells and macrophages  Academic Article
• Viral cross talk: Intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver  Academic Article
• Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease  Academic Article
• Viral interleukin-10 (IL-10), the human herpes-virus-4 cellular IL-10 homolog, induces local anergy to allogeneic and syngeneic tumors  Academic Article
• Viral nanoparticles associate with regions of inflammation and blood brain barrier disruption during CNS infection  Academic Article
• Viral rna induces type i interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5 implications for viral infection-associated glomerulonephritis  Academic Article
• Viral targeting of hematopoietic progenitors and inhibition of dc maturation as a dual strategy for immune subversion  Academic Article
• Virus specificity of cytotoxic T lymphocytes generated during acute lymphocytic choriomeningitis virus infection: role of the H-2 region in determining cross-reactivity for different lymphocytic choriomeningitis virus strains  Academic Article
• Virus-induced immune complex disease: genetic control of C1q binding complexes in the circulation of mice persistently infected with lymphocytic choriomeningitis virus  Academic Article
• Virus-induced immunosuppression .1. Age at infection relates to a selective or generalized defect  Academic Article
• Visualization of the genesis and fate of isotype-switched b cells during a primary immune response  Academic Article
• Visualizing cold spots: TRPM8-expressing sensory neurons and their projections  Academic Article
• Visualizing the viral burden: Phenotypic and functional alterations of t cells and apcs during persistent infection  Academic Article
• Vitronectin gene expression in vivo. Evidence for extrahepatic synthesis and acute phase regulation  Academic Article
• Voronoi binding site model of a polycyclic aromatic hydrocarbon binding protein  Academic Article
• Weight-loss in obese mice persistently infected with lymphocytic choriomeningitis virus is not associated with elevated tumor necrosis factor cachectin activity in peritoneal-macrophages  Academic Article
• Whole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration  Academic Article
• Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes  Academic Article
• Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo  Academic Article
• Wiring and molecular features of prefrontal ensembles representing distinct experiences  Academic Article
• X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C  Academic Article
• Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone BXSB mice  Academic Article
• ZBTB1 is a determinant of lymphoid development  Academic Article
• Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice  Academic Article
• betaCaMKII in lateral habenula mediates core symptoms of depression  Academic Article
• delta BAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models  Academic Article
• mu-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche  Academic Article
• rAAV9 combined with renal vein injection is optimal for kidney-targeted gene delivery: conclusion of a comparative study  Academic Article
• Δ9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice  Academic Article
• α8-integrins are required for hippocampal long-term potentiation but not for hippocampal-dependent learning  Academic Article
• β-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB₁ or CB₂ receptors  Academic Article