subject area of

• 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation  Academic Article
• 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia  Academic Article
• 11-deoxy prostaglandin F(2 alpha), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3(-/-) females  Academic Article
• 5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission  Academic Article
• 5-HT(7) receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern  Academic Article
• 5-aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor alpha-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent  Academic Article
• A 3-dimensional extracellular matrix as a delivery system for the transplantation of glioma-targeting neural stem/progenitor cells  Academic Article
• A 5' leader of Rbm3, a cold stress-induced mRNA, mediates internal initiation of translation with increased efficiency under conditions of mild hypothermia  Academic Article
• A DNA vaccine against vegf receptor 2 prevents effective angiogenesis and inhibits tumor growth  Academic Article
• A DNA vaccine targeting fos-related antigen 1 enhanced by il-18 induces long-lived t-cell memory against tumor recurrence  Academic Article
• A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication  Academic Article
• A Deep Learning Approach to Antibiotic Discovery  Academic Article
• A Jekyll and Hyde profile: Type 1 interferon signaling plays a prominent role in the initiation and maintenance of a persistent virus infection  Academic Article
• A Naive-Like Population of Human CD1d-Restricted T Cells Expressing Intermediate Levels of Promyelocytic Leukemia Zinc Finger  Academic Article
• A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model  Academic Article
• A ZAP-70 kinase domain variant prevents thymocyte- positive selection despite signalling CD69 induction  Academic Article
• A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation  Academic Article
• A catechol-O-methyltransferase that is essential for auditory function in mice and humans  Academic Article
• A chemically induced vaccine strategy for prostate cancer  Academic Article
• A chimeric mouse model of Gaucher disease  Academic Article
• A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol  Academic Article
• A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy  Academic Article
• A derivative of the melanocortin receptor antagonist shu9119 (pg932) increases food intake when administered peripherally  Academic Article
• A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use  Academic Article
• A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4(-)CD8(-) to CD4(+) CD8(+) thymocytes  Academic Article
• A dual role for microglia in promoting tissue inhibitor of metalloproteinase (timp) expression in glial cells in response to neuroinflammatory stimuli  Academic Article
• A factor IX-deficient mouse model for hemophilia B gene therapy  Academic Article
• A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function  Academic Article
• A functional genomics strategy reveals Rora as a component of the mammalian circadian clock  Academic Article
• A genetic determinant that specifically regulates the frequency of hematopoietic stem cells  Academic Article
• A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing  Academic Article
• A gfp-equipped bidirectional expression module well suited for monitoring tetracycline-regulated gene expression in mouse  Academic Article
• A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity  Academic Article
• A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia  Academic Article
• A keratinocyte-responsive gamma delta tcr is necessary for dendritic epidermal t cell activation by damaged keratinocytes and maintenance in the epidermis  Academic Article
• A lack of mu-opioid receptors modulates the expressions of neuropeptide y and substance p mrna  Academic Article
• A leukocyte homologue of the il-8 receptor cxcr-2 mediates the accumulation of macrophages in atherosclerotic lesions of ldl receptor-deficient mice  Academic Article
• A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses  Academic Article
• A major histocompatibility complex class I-dependent subset of memory phenotype CD8(+) cells  Academic Article
• A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration  Academic Article
• A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice  Academic Article
• A multivalent minigene vaccine, containing b-cell, cytotoxic t-lymphocyte, and t-h epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen  Academic Article
• A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen  Academic Article
• A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation  Academic Article
• A new UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase mRNA exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain  Academic Article
• A novel DNA vaccine encoding pdgfr beta suppresses growth and dissemination of murine colon, lung and breast carcinoma  Academic Article
• A novel ELISA for mouse activated protein C in plasma  Academic Article
• A novel allele of myosin viia reveals a critical function for the c-terminal ferm domain for melanosome transport in retinal pigment epithelial cells  Academic Article
• A novel and simple method for culturing pericytes from mouse brain  Academic Article
• A novel approach for in vivo measurement of mouse red cell redox status  Academic Article
• A novel class II MHC molecule with unusual tissue distribution  Academic Article
• A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects  Academic Article
• A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis  Academic Article
• A novel generation of heparan sulfate mimetics for the treatment of prion diseases  Academic Article
• A novel method for analysis of nuclear receptor function at natural promoters: Peroxisome proliferator-activated receptor gamma agonist actions on ap2 gene expression detected using branched DNA messenger rna quantitation  Academic Article
• A novel method to establish microglia-free astrocyte cultures: Comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia  Academic Article
• A novel neuron-specific DNA end-binding factor in the murine brain  Academic Article
• A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1β  Academic Article
• A novel transgenic mouse model for immunological evaluation of carcinoembryonic antigen-based DNA minigene vaccines  Academic Article
• A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests  Academic Article
• A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects  Academic Article
• A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity  Academic Article
• A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration  Academic Article
• A peptide that antagonizes tcr-mediated reactions with both syngeneic and allogeneic agonists: Functional and structural aspects  Academic Article
• A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones  Academic Article
• A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins  Academic Article
• A photo-cleavable biotin affinity tag for the facile release of a photo-crosslinked carbohydrate-binding protein  Academic Article
• A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase ii in t cells: From activation to unresponsiveness  Academic Article
• A point mutation in sec61 alpha 1 leads to diabetes and hepatosteatosis in mice  Academic Article
• A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding  Academic Article
• A population of murine gamma delta T cells that recognize an inducible MHC class Ib molecule  Academic Article
• A possible oligosaccharide-conjugate vaccine candidate for Clostridium difficile is antigenic and immunogenic  Academic Article
• A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake  Academic Article
• A ppar gamma-lxr-abca1 pathway in macrophages is involved in cholesterol efflux and atherogenesis  Academic Article
• A proapoptotic peptide for the treatment of solid tumors  Academic Article
• A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions  Academic Article
• A rabbit antiserum detects a vh j558 subgroup marker highly expressed among anti-alprenolol antibodies  Academic Article
• A regenerative approach to the treatment of multiple sclerosis  Academic Article
• A reversible S-adenosyl-L-homocysteine hydrolase inhibitor ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell activation  Academic Article
• A role for dual viral hits in causation of subacute sclerosing panencephalitis  Academic Article
• A role for skin γδ T cells in wound repair  Academic Article
• A role for tcr affinity in regulating naive t cell homeostasis  Academic Article
• A role for the GIRK3 subunit in methamphetamine-induced aAttenuation of GABA(B) receptor-activated GIRK currents in VTA dopamine neurons  Academic Article
• A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition  Academic Article
• A role of the fast ATP-gated P2X(1) cation channel in thrombosis of small arteries in vivo  Academic Article
• A secreted Slit2 fragment regulates adipose tissue thermogenesis and metabolic function  Academic Article
• A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens  Academic Article
• A semisynthetic carbohydrate-lipid vaccine that protects against S-pneumoniae in mice  Academic Article
• A shared neural ensemble links distinct contextual memories encoded close in time  Academic Article
• A spontaneous rheumatoid arthritis-like disease in mrl/1 mice  Academic Article
• A spontaneously arising pancreatic tumor does not promote the differentiation of naive CD8+ T lymphocytes into effector CTL  Academic Article
• A stress response pathway regulates DNA damage through beta(2)-adrenoreceptors and beta-arrestin-1  Academic Article
• A string-of-beads vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge  Academic Article
• A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation  Academic Article
• A study of complexes of class II invariant chain peptide: major histocompatibility complex class II molecules using a new complex-specific monoclonal antibody  Academic Article
• A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors  Academic Article
• A t-cell receptor-v-alpha region selectively expressed in cd4+ cells  Academic Article
• A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria  Academic Article
• A transgenic mouse model for measles virus infection of the brain  Academic Article
• A transgenic mouse model of the chronic hepatitis B surface antigen carrier state  Academic Article
• A transgenic mouse model to assess the interaction of cytotoxic t-lymphocytes with virally infected, class-i mhc-expressing astrocytes  Academic Article
• A v(h)11v(kappa)9b cell antigen receptor drives generation of cd5(+) b cells both in vivo and in vitro  Academic Article
• A view from above: Cloud plots to visualize global metabolomic data  Academic Article
• A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes  Academic Article
• ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC  Academic Article
• ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells  Academic Article
• AMPAR-independent effect of striatal αCaMKII promotes the sensitization of cocaine reward  Academic Article
• ASPP2 deficiency causes features of 1q41q42 microdeletion syndrome  Academic Article
• ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor  Academic Article
• ATP-sensitive potassium channel (K-ATP)-dependent regulation of cardiotropic viral infections  Academic Article
• Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6  Academic Article
• Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity  Academic Article
• Ablation of cd22 in ligand-deficient mice restores b cell receptor signaling  Academic Article
• Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice  Academic Article
• Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model  Academic Article
• Absence of CTL responses to early viral antigens facilitates viral persistence  Academic Article
• Absence of LPA1 signaling results in defective cortical development  Academic Article
• Absence of carbohydrate response element binding protein in adipocytes causes systemic insulin resistance and impairs glucose transport  Academic Article
• Absence of the alpha v beta 3 integrin dictates the time-course of angiogenesis in the hypoxic central nervous system: Accelerated endothelial proliferation correlates with compensatory increases in alpha 5 beta 1 integrin expression  Academic Article
• Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass  Academic Article
• Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging  Academic Article
• Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice  Academic Article
• Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1  Academic Article
• Activated protein C preserves functional islet mass after intraportal transplantation - a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death  Academic Article
• Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3  Academic Article
• Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1  Academic Article
• Activated protein C targets CD8(+) dendritic cells to reduce the mortality of endotoxemia in mice  Academic Article
• Activation kinetics and off-target effects of thymus-initiated cre transgenes  Academic Article
• Activation of PPARdelta alters lipid metabolism in db/db mice  Academic Article
• Activation of liver x receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue  Academic Article
• Activation of lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury  Academic Article
• Activation of multidrug resistance (P-glycoprotein) mdr3/mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice  Academic Article
• Activation of murine cd4(+) and cd8(+) t lymphocytes leads to dramatic remodeling of n-linked glycans  Academic Article
• Activation of preexisting t cell clones by targeted interleukin 2 therapy  Academic Article
• Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats  Academic Article
• Activation of the alternative complement pathway by fetal calf serum and mouse thymocytes  Academic Article
• Activation of the endocannabinoid system by organophosphorus nerve agents  Academic Article
• Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins  Academic Article
• Activators of the nuclear receptor ppar gamma enhance colon polyp formation  Academic Article
• Acute exposure to cxc chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices  Academic Article
• Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice  Academic Article
• Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-- Jakob disease: implications for human health  Academic Article
• Adenoviral delivery of CTLA4ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients  Academic Article
• Adenoviral-mediated, intratumor gene transfer of interleukin 23 induces a therapeutic antitumor response  Academic Article
• Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice  Academic Article
• Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone  Academic Article
• AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin  Academic Article
• Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs  Academic Article
• Adjuvant activity of the histamine-sensitizing factor of Bordetella pertussis in different strains of mice  Academic Article
• Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice  Academic Article
• Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling  Academic Article
• Administration of Murine Stromal Vascular Fraction Ameliorates Chronic Experimental Autoimmune Encephalomyelitis  Academic Article
• Administration of systemic or local interleukin-2 enhances the antitumor effects of interleukin-12 gene-therapy  Academic Article
• Adoptive immunotherapy induces cns dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection  Academic Article
• Adoptive transfer of fluorescence-labeled cells shows that resident peritoneal-macrophages are able to migrate into specialized lymphoid organs and inflammatory sites in the mouse  Academic Article
• Adropin deficiency is associated with increased adiposity and insulin resistance  Academic Article
• Adult mice generated from induced pluripotent stem cells  Academic Article
• Afamin secreted from nonresorbing osteoclasts acts as a chemokine for preosteoblasts via the Akt-signaling pathway  Academic Article
• Age of the Donor Reduces the Ability of Human Adipose-Derived Stem Cells to Alleviate Symptoms in the Experimental Autoimmune Encephalomyelitis Mouse Model  Academic Article
• Age- and gender-specific changes of hypocretin immunopositive neurons in C57Bl/6 mice  Academic Article
• Age-dependent loss of sperm production in mice via impaired tysophosphatidic acid signaling  Academic Article
• Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability  Academic Article
• Aged app23 mice show a delay in switching to the use of a strategy in the barnes maze  Academic Article
• Aging accelerates endotoxin-induced thrombosis: increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging  Academic Article
• Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue  Academic Article
• Aging leads to disturbed homeostasis of memory phenotype cd8(+) cells  Academic Article
• Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics  Academic Article
• Allelic exclusion of mouse t-cell receptor-alpha chains occurs at the time of thymocyte tcr up-regulation  Academic Article
• Allelic exclusion of the tcr alpha-chain is an active process requiring tcr-mediated signaling and c-cbl  Academic Article
• Alloantibodies can discriminate class I major histocompatibility complex molecules associated with various endogenous peptides  Academic Article
• Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus  Academic Article
• Allosteric activators of glucokinase: potential role in diabetes therapy  Academic Article
• Alpha 8 integrin in glomerular mesangial cells and in experimental glomerulonephritis  Academic Article
• Alterations in neural cell-adhesion molecules during development of different regions of the nervous-system  Academic Article
• Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice  Academic Article
• Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor  Academic Article
• Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus  Academic Article
• Altered functional and biochemical response by CD8+ T cells that remain after tolerance  Academic Article
• Altered helper T lymphocyte function associated with chronic hepatitis B virus infection and its role in response to therapeutic vaccination in humans  Academic Article
• Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6  Academic Article
• Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1 alpha  Academic Article
• Alternatively spliced tissue factor induces angiogenesis through integrin ligation  Academic Article
• Amelioration of chronic murine colitis by peptide-mediated transduction of the I kappa B kinase inhibitor NEMO binding domain peptide  Academic Article
• Amisulpride is a potent 5-ht(7) antagonist: Relevance for antidepressant actions in vivo  Academic Article
• Among cxcr3 chemokines, ifn-gamma-inducible protein of 10 kda (cxc chemokine ligand (cxcl) 10) but not monokine induced by ifn-gamma (cxcl9) imprints a pattern for the subsequent development of autoimmune disease  Academic Article
• Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction  Academic Article
• Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD  Academic Article
• Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: A possible model for senile systemic amyloidosis  Academic Article
• Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model  Academic Article
• An IRF-3-, IRF-5-, and IRF-7-independent pathway of dengue viral resistance utilizes IRF-1 to stimulate type I and II interferon responses  Academic Article
• An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides  Academic Article
• An activated protein c analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents  Academic Article
• An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model  Academic Article
• An activity-based imaging probe for the integral membrane hydrolase KIAA1363  Academic Article
• An ahemolytic pneumolysin of Streptococcus pneumoniae manipulates human innate and CD4⁺ T-cell responses and reduces resistance to colonization in mice in a serotype-independent manner  Academic Article
• An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization  Academic Article
• An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription  Academic Article
• An angiogenic role for the alpha 5 beta 1 integrin in promoting endothelial cell proliferation during cerebral hypoxia  Academic Article
• An anti-apoptotic peptide improves survival in lethal total body irradiation  Academic Article
• An antibody-interleukin 2 fusion protein overcomes tumor heterogeneity by induction of a cellular immune response  Academic Article
• An apolipoprotein e synthetic peptide targets to lipoproteins in plasma and mediates both cellular lipoprotein interactions in vitro and acute clearance of cholesterol-rich lipoproteins in vivo  Academic Article
• An autologous oral DNA vaccine protects against murine melanoma  Academic Article
• An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. II. Mammalian fibroblast cultures transformed by DNA and RNA tumor viruses  Academic Article
• An essential role for Rxr alpha in the development of Th2 responses  Academic Article
• An oral DNA vaccine against human carcinoembryonic antigen (cea) prevents growth and dissemination of lewis lung carcinoma in cea transgenic mice  Academic Article
• Analysis of antigen-specific B-cell memory directly ex vivo  Academic Article
• Analysis of central b cell tolerance in autoimmune-prone mrl/lpr mice bearing autoantibody transgenes  Academic Article
• Analysis of individual immunoglobulin-lambda light-chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center b-cell somatic mutation  Academic Article
• Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools  Academic Article
• Analysis of the MCMV resistome by ENU mutagenesis  Academic Article
• Analysis of the effect of estrogen/androgen perturbation on penile development in transgenic and diethylstilbestrol-Treated mice  Academic Article
• Analysis of the proteolysis of bioactive peptides using a peptidomics approach  Academic Article
• Analysis of the therapeutic functions of novel melanocortin receptor agonists in mc3r-and mc4r-deficient c57bl/6j mice  Academic Article
• Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum  Academic Article
• Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors  Academic Article
• Anchorless prion protein results in infectious amyloid disease without clinical scrapie  Academic Article
• Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development  Academic Article
• Angiomotin regulates endothelial cell migration during embryonic angiogenesis  Academic Article
• Animal model of respiratory syncytial virus: CD8(+) T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy  Academic Article
• Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation  Academic Article
• Antagonizing peroxisome proliferator-activated receptor α activity selectively enhances Th1 immunity in male mice  Academic Article
• Anti-Gag cytolytic T lymphocytes specific for an alternative translational reading frame-derived epitope and resistance versus susceptibility to retrovirus-induced murine AIDS in F(1) mice  Academic Article
• Anti-IFN-alpha/beta receptor antibody treatment ameliorates disease in lupus-predisposed mice  Academic Article
• Anti-OX40 stimulation in vivo enhances CD8(+) memory T cell survival and significantly increases recall responses  Academic Article
• Anti-apoptotic peptides protect against radiation-induced cell death  Academic Article
• Anti-cd11b antibody prevents immunopathologic changes in viable moth-eaten bone-marrow chimeric mice  Academic Article
• Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones  Academic Article
• Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke  Academic Article
• Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37  Academic Article
• Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism  Academic Article
• Anticonvulsant activity of a nonpeptide galanin receptor agonist  Academic Article
• Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation  Academic Article
• Antidiabetic activity of a highly potent and selective nonpeptide somatostatin receptor subtype-2 agonist  Academic Article
• Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin/cd169  Academic Article
• Antigen presentation in retroviral vector-mediated gene transfer in vivo  Academic Article
• Antigen-driven B cell differentiation in vivo  Academic Article
• Antigen-induced unresponsiveness results in altered t cell signaling  Academic Article
• Antigen-specific b cell memory: Expression and replenishment of a novel b220(-) memory b cell compartment  Academic Article
• Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency  Academic Article
• Antigen-specific naive CD8(+) T cells produce a single pulse of IFN-gamma in vivo within hours of infection, but without antiviral effect  Academic Article
• Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis  Academic Article
• Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress  Academic Article
• Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids - recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein  Academic Article
• Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus  Academic Article
• Antiproliferation activity of a small molecule repressor of liver receptor homolog 1  Academic Article
• Antipsychotic drug treatment alters expression of mrnas encoding lipid metabolism-related proteins  Academic Article
• Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models  Academic Article
• Anxiolytic-Like Effects of Antisauvagine-30 in Mice Are Not Mediated by CRF2 Receptors  Academic Article
• ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo  Academic Article
• Apoa1 reduces free cholesterol accumulation in atherosclerotic lesions of apoe-deficient mice transplanted with apoe-expressing macrophages  Academic Article
• Architecture of cannabinoid signaling in mouse retina  Academic Article
• Area specificity and topography of thalamocortical projections are controlled by ephrin/eph genes  Academic Article
• Arenavirus genome rearrangement for the development of live attenuated vaccines  Academic Article
• Arginine 54 and tyrosine 118 residues of αA-crystallin are crucial for lens formation and transparency  Academic Article
• Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction  Academic Article
• Arylsulfonamide kcn1 inhibits in vivo glioma growth and interferes with hif signaling by disrupting hif-1 alpha interaction with cofactors p300/cbp  Academic Article
• Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord  Academic Article
• Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice  Academic Article
• Assessing interactions between Ghsr and Mc3r reveals a role for AgRP in the expression of food anticipatory activity in male mice  Academic Article
• Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors  Academic Article
• Association of cartilage-specific deletion of peroxisome proliferator-activated receptor gamma with abnormal endochondral ossification and impaired cartilage growth and development in a murine model  Academic Article
• Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina  Academic Article
• Astrocyte pVHL and HIF-alpha isoforms are required for embryonic-to-adult vascular transition in the eye  Academic Article
• Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis  Academic Article
• Astrocytes contribute to gamma oscillations and recognition memory  Academic Article
• Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming  Academic Article
• Atheroprotective potential of macrophage-derived phospholipid transfer protein in low-density lipoprotein receptor-deficient mice is overcome by apolipoprotein ai overexpression  Academic Article
• Atherosclerosis in mice is not affected by a reduction in tissue factor expression  Academic Article
• Attenuation of allergic contact dermatitis through the endocannabinoid system  Academic Article
• Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: Involvement of regulatory T cells  Academic Article
• Aurora kinases a and b are up-regulated by myc and are essential for maintenance of the malignant state  Academic Article
• Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects  Academic Article
• Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells  Academic Article
• Autologous regulation of naive t cell homeostasis within the t cell compartment  Academic Article
• Automatic annotation of matrix-assisted laser desorption/ionization n-glycan spectra  Academic Article
• Autophagy activation by rapamycin reduces severity of experimental osteoarthritis  Academic Article
• Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis  Academic Article
• Autotaxin and lysophosphatidic acid(1) receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine  Academic Article
• Avidity of cd1d-ligand-receptor ternary complex contributes to t-helper 1 (th1) polarization and anticancer efficacy  Academic Article
• Azetidine and piperidine carbamates as efficient, covalent inhibitors of monoacylglycerol lipase  Academic Article
• B cell selection defects underlie the development of diabetogenic apcs in nonobese diabetic mice  Academic Article
• B cell-derived IL-27 promotes control of persistent LCMV infection  Academic Article
• B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates  Academic Article
• B-cell development in mice that lack one or both immunoglobulin kappa-light chain genes  Academic Article
• B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of v-beta-5(+) thymocytes  Academic Article
• B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function  Academic Article
• BCR engagement induces Fas resistance in primary B cells in the absence of functional Bruton's tyrosine kinase  Academic Article
• BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice  Academic Article
• BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission  Academic Article
• BK channel β1 subunit contributes to behavioral adaptations elicited by chronic intermittent ethanol exposure  Academic Article
• Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid.  Academic Article
• Barx2 is expressed in satellite cells and is required for normal muscle growth and regeneration  Academic Article
• Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences  Academic Article
• Basomedial amygdala mediates top-down control of anxiety and fear  Academic Article
• Bax loss impairs myc-induced apoptosis and circumvents the selection of p53 mutations during myc-mediated lymphomagenesis  Academic Article
• Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis  Academic Article
• Bcr ligation induces receptor editing in igm(+)igd(-) bone marrow b cells in vitro  Academic Article
• Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex  Academic Article
• Behavioral and neural correlates of acute and scheduled hunger in C57BL/6 mice  Academic Article
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• Characterization of kappa opioid receptor mediated, dynorphin-stimulated [(35)S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting  Academic Article
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• Characterization of mouse mutants with abnormal RPE cells  Academic Article
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• Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes  Academic Article
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• Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system  Academic Article
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• Connexin mediated cataract prevention in mice  Academic Article
• Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo  Academic Article
• Consequences of self-presentation of peptide antigen by cytolytic T lymphocytes  Academic Article
• Conserved amino acid residues in the complementarity-determining region 1 of the TCR β-chain are involved in the recognition of conventional Ag and Mls-1 superantigen  Academic Article
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• Dendritic cell-based genetic immunization in mice with a recombinant adenovirus encoding murine TRP2 induces effective anti-melanoma immunity  Academic Article
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• Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or-4 receptors  Academic Article
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• Knockout of toll-like receptor-2 attenuates both the proinflammatory state of diabetes and incipient diabetic nephropathy  Academic Article
• Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes  Academic Article
• Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis  Academic Article
• Kv4.2 mediates histamine modulation of preoptic neuron activity and body temperature  Academic Article
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• LPA1 receptor activation promotes renal interstitial fibrosis  Academic Article
• LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation  Academic Article
• LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA)  Academic Article
• LXR-mediated inhibition of CD4(+) T helper cells  Academic Article
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• Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease  Academic Article
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• Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity  Academic Article
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• Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size  Academic Article
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• Lipopolysaccharide sensing an important factor in the innate immune response to gram-negative bacterial infections: Benefits and hazards of lps hypersensitivity  Academic Article
• Lipopolysaccharide-induced il-12 expression in the central nervous system and cultured astrocytes and microglia  Academic Article
• Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium  Academic Article
• Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile x syndrome  Academic Article
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• Long latency event-related potentials in mice: Effects of stimulus characteristics and strain  Academic Article
• Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling  Academic Article
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• Loss of bax alters tumor spectrum and tumor numbers in arf-deficient mice  Academic Article
• Loss of medial septal modulation of dentate gyrus physiology in young mice overexpressing human β-amyloid precursor protein  Academic Article
• Loss of nicotine-induced behavioral sensitization in mu-opioid receptor knockout mice  Academic Article
• Loss of sex discrimination and male-male aggression in mice deficient for trp2  Academic Article
• Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome  Academic Article
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• Ly phenotype and mechanism of action of mouse neonatal suppressor T cells  Academic Article
• Lyb-7, a new B cell alloantigen controlled by genes linked to the IgCH locus  Academic Article
• Lymphocyte-mediated alopecia in c57bl/6 mice following successful immunotherapy for melanoma  Academic Article
• Lymphoid reservoirs of antigen-specific memory t helper cells  Academic Article
• Lymphoproliferative disease and autoimmunity in mice with increased mir-17-92 expression in lymphocytes  Academic Article
• Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: Evidence against dendritic cell involvement in neuroinvasion  Academic Article
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• Lysophosphatidic acid stimulates the intestinal brush border NA(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF  Academic Article
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• Lysosomal glycosphingolipid recognition by NKT cells  Academic Article
• MAIT cells are imprinted by the microbiota in early life and promote tissue repair  Academic Article
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• Male germ cells support long-term propagation of Zika virus  Academic Article
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• Manipulating a "cocaine engram" in mice  Academic Article
• Manipulation of Panx1 activity increases the engraftment of transplanted lacrimal gland epithelial progenitor cells  Academic Article
• Manufacture of a functional cdna for the h-2db molecule using a retroviral shuttle vector  Academic Article
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• Mapping murine loci for seizure response to kainic acid  Academic Article
• Mapping of epitopes recognized by alloreactive cytotoxic T lymphocytes using inhibition by MHC peptides  Academic Article
• Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain  Academic Article
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• Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk  Academic Article
• Maternal b lymphocytes specific for paternal histocompatibility antigens are partially deleted during pregnancy  Academic Article
• Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity  Academic Article
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• Measles virus infects and suppresses proliferation of t lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule  Academic Article
• Measles virus interacts with human slam receptor on dendritic cells to cause immuno suppression  Academic Article
• Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells  Academic Article
• Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis  Academic Article
• Mechanisms of class-I restricted immunopathology - A transgenic mouse model of fulminant-hepatitis  Academic Article
• Mechanisms of group b streptococcal-induced apoptosis of murine macrophages  Academic Article
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• Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat  Academic Article
• Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes  Academic Article
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• Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms  Academic Article
• Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects  Academic Article
• Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia  Academic Article
• Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota  Academic Article
• Metabolic benefit of chronic caloric restriction and activation of hypothalamic AGRP/NPY neurons in male mice is independent of ghrelin  Academic Article
• Metabolic characterization of a mouse deficient in all known leptin receptor isoforms  Academic Article
• Metabolic damage and premature thymus aging caused by stromal catalase deficiency  Academic Article
• Metabolic depression and increased reactive oxygen species production by isolated mitochondria at moderately lower temperatures  Academic Article
• Metabolomic profiling reveals severe skeletal muscle group-specific perturbations of metabolism in aged FBN rats  Academic Article
• Metformin inhibits hepatic mTORC1 signaling via dose-dependent mechanisms involving AMPK and the TSC complex  Academic Article
• Mice deficient in stem cell antigen-1 (sca1, ly-6a/e) develop normal primary and memory cd4(+) and cd8(+) t-cell responses to virus infection  Academic Article
• Mice devoid of interferon regulatory factor-1 (irf-1) show normal expression of type-i interferon genes  Academic Article
• Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons  Academic Article
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• Mice lacking the beta4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia  Academic Article
• Mice lacking tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memory  Academic Article
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• MicroRNA-140 plays dual roles in both cartilage development and homeostasis  Academic Article
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• MicroRNA-221-222 regulate the cell cycle in mast cells  Academic Article
• MicroRNAs of the miR-17 similar to 92 family are critical regulators of T-FH differentiation  Academic Article
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• Microfluidic amperometric sensor for analysis of nitric oxide in whole blood  Academic Article
• Microfluidic source-sink model reveals effects of biophysically distinct CXCL12 isoforms in breast cancer chemotaxis  Academic Article
• Microglia are the major source of TNF-α and TGF-β1 in postnatal glial cultures; regulation by cytokines, lipopolysaccharide, and vitronectin  Academic Article
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• Microrna-219 modulates nmda receptor-mediated neurobehavioral dysfunction  Academic Article
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• Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes  Academic Article
• Mouse model of subretinal neovascularization with choroidal anastomosis  Academic Article
• Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration  Academic Article
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• Mu-opioid receptor knockout mice do not self-administer alcohol  Academic Article
• Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: Lack of ethanol interactions  Academic Article
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• Murine cytomegalovirus infection down-regulates mhc class ii expression on macrophages by induction of il-10  Academic Article
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• Murine tissue factor gene expression in vivo. Tissue and cell specificity and regulation by lipopolysaccharide  Academic Article
• Mutability of prions  Academic Article
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• Mycobacteria inhibit nitric oxide synthase recruitment to phagosomes during macrophage infection  Academic Article
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• Negative selection of T cells occurs throughout thymic development  Academic Article
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• Neurobiological signatures of alcohol dependence revealed by protein profiling  Academic Article
• Neurogenin2 regulates the initial axon guidance of cortical pyramidal neurons projecting medially to the corpus callosum  Academic Article
• Neuroimmune regulation of alcohol consumption: Behavioral validation of genes obtained from genomic studies  Academic Article
• Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin-6  Academic Article
• Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury  Academic Article
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• Neurotoxicity of the putative transmembrane domain of the prion protein  Academic Article
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• Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism  Academic Article
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• Overexpression of interleukin-10 by activated t lymphocytes inhibits atherosclerosis in ldl receptor-deficient mice by altering lymphocyte and macrophage phenotypes  Academic Article
• Overlapping and distinct functions of CstF64 and CstF64 tau in mammalian mRNA 3' processing  Academic Article
• Overproduction of corticotropin-releasing factor in transgenic mice - a genetic model of anxiogenic behavior  Academic Article
• Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein  Academic Article
• P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice  Academic Article
• PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis  Academic Article
• PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection  Academic Article
• PAR1 regulation of CXCL1 expression and neutrophil recruitment to the lung in mice infected with influenza A virus  Academic Article
• PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells  Academic Article
• PER1 phosphorylation specifies feeding rhythm in mice  Academic Article
• PI3K-mediated negative feedback regulation of IL-12 production in DCs  Academic Article
• PLZF expression maps the early stages of ILC1 lineage development  Academic Article
• PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions  Academic Article
• PPAR delta regulates multiple proinflammatory pathways to suppress atherosclerosis  Academic Article
• PRMT5-mediated regulation of developmental myelination  Academic Article
• PTD-mediated loading of tumor-seeking lymphocytes with prodrug-activating enzymes  Academic Article
• PTPN22 alters the development of regulatory T cells in the thymus  Academic Article
• PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells  Academic Article
• PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45  Academic Article
• Palmitoylation-dependent activation of MC1R prevents melanomagenesis  Academic Article
• PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development  Academic Article
• Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells  Academic Article
• Pancreatic-islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction  Academic Article
• Papillorenal syndrome-causing missense mutations in PAX2/Pax2 result in hypomorphic alleles in mouse and human  Academic Article
• Parameters governing exhaustion of rare T cell-independent neutralizing IgM-producing B cells after LCMV infection  Academic Article
• Paranodal reorganization results in the depletion of transverse bands in the aged central nervous system  Academic Article
• Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1  Academic Article
• Participation of the major histocompatibility complex in antibody recognition of viral antigens expressed on infected cells  Academic Article
• Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients  Academic Article
• Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus  Academic Article
• Pathogenesis of the oral route of infection of mice with scrapie and bovine spongiform encephalopathy agents  Academic Article
• Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses  Academic Article
• Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris  Academic Article
• Pathogenic relevance of IgG and IgM antibodies against desmoglein 3 in blister formation in pemphigus vulgaris  Academic Article
• Patterns of cytokine gene expression by CD4+ T cells from young and old mice  Academic Article
• Patterns of immune reactivity in auto-immune murine strains .1. Cell-mediated immune-responses induced by h-2 identical and h-2 incompatible stimulator cells  Academic Article
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• Paucity of V-D-D-J rearrangements and V-H replacement events in lupus prone and nonautoimmune TdT(-/-) and TdT(+/+) mice  Academic Article
• Peanut agglutinin high phenotype of activated cd8(+) t cells results from de novo synthesis of cd45 glycans  Academic Article
• Pejvakin, a candidate stereociliary rootlet protein, regulates hair cell function in a cell-autonomous manner  Academic Article
• Peptide nanofibers preconditioned with stem cell secretome are renoprotective  Academic Article
• Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious CD8 T cell-mediated, TNF-dependent immunopathology  Academic Article
• Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis  Academic Article
• Peptidergic regulation of plasminogen activator inhibitor-1 gene expression in vivo  Academic Article
• Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides  Academic Article
• Peptidomics of prolyl endopeptidase in the central nervous system  Academic Article
• Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus  Academic Article
• Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis  Academic Article
• Peptidylariginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates  Academic Article
• Periodontal dysbiosis linked to periodontitis is associated with cardiometabolic adaptation to high-fat diet in mice  Academic Article
• Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen  Academic Article
• Peripheral deletion of CD8 T cells requires p38 MAPK in cross-presenting dendritic cells  Academic Article
• Peripheral reduction of beta-amyloid is sufficient to reduce brain beta-amyloid: Implications for alzheimer's disease  Academic Article
• Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle  Academic Article
• Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase  Academic Article
• Persistent LCMV infection is controlled by blockade of type I interferon signaling  Academic Article
• Persistent histamine excitation of glutamatergic preoptic neurons  Academic Article
• Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice  Academic Article
• Persistent virus infection inhibits type i interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections  Academic Article
• Pharmacokinetics and efficacy of the spleen tyrosine kinase inhibitor r406 after ocular delivery for retinoblastoma  Academic Article
• Pharmacological Activation of Non-canonical NF-kappa B Signaling Activates Latent HIV-1 Reservoirs In Vivo  Academic Article
• Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence  Academic Article
• Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo  Academic Article
• Pharmacological and behavioral profile of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-chinolincarboxamide (EVP-5141), a novel α7 nicotinic acetylcholine receptor agonist/serotonin 5-HT3 receptor antagonist  Academic Article
• Pharmacological and genetic modulation of REV-ERB activity and expression affects orexigenic gene expression  Academic Article
• Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A)  Academic Article
• Pharmacological characterization of a selective agonist for bombesin receptor subtype-3  Academic Article
• Pharmacological selectivity within class I histone deacetylases predicts effects on synaptic function and memory rescue  Academic Article
• Pharmacological studies of a new derivative of amphotericin-B, MS-8209, in mouse and hamster scrapie  Academic Article
• Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour  Academic Article
• Pharmacological targeting of the thrombomodulin-activated protein c pathway mitigates radiation toxicity  Academic Article
• Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal  Academic Article
• Phenotype, function, and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGF-beta  Academic Article
• Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests  Academic Article
• Phenotypic characterization of a genetically diverse panel of mice for behavioral despair and anxiety  Academic Article
• Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia  Academic Article
• Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors  Academic Article
• Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory  Academic Article
• Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4)  Academic Article
• Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells  Academic Article
• Physical association of histocompatibility antigens and tumor-associated antigens on the surface of murine lymphoma-cells  Academic Article
• Physiological and behavioral effects of methamphetamine in a mouse model of endotoxemia: a preliminary study  Academic Article
• Piezo1 in smooth muscle cells is involved in hypertension-dependent arterial remodeling  Academic Article
• Plasma cells negatively regulate the follicular helper t cell program  Academic Article
• Plasma membrane vesicles decorated with glycolipid-anchored antigens and adjuvants via protein transfer as an antigen delivery platform for inhibition of tumor growth  Academic Article
• Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses  Academic Article
• Plasmid DNA encoding human carcinoembryonic antigen (cea) adsorbed onto cationic microparticles induces protective immunity against colon cancer in cea-transgenic mice  Academic Article
• Plasminogen activator inhibitor-1 and its cofactor vitronectin stabilize arterial thrombi after vascular injury in mice  Academic Article
• Plasminogen activator inhibitor-1 is a major stress-regulated gene: Implications for stress-induced thrombosis in aged individuals  Academic Article
• Plasminogen has a broad extrahepatic distributions  Academic Article
• Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite  Academic Article
• Platelet glycoprotein Ib alpha supports experimental lung metastasis  Academic Article
• Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia  Academic Article
• Platelet, not endothelial, p-selectin is required for neointimal formation after vascular injury  Academic Article
• Platelets adhere to and translocate on von Willebrand factor presented by endothelium in simulated veins  Academic Article
• Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage  Academic Article
• Platelets mediate cytotoxic T lymphocyte-induced liver damage  Academic Article
• Platelets prevent IFN-α/β-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus  Academic Article
• Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains  Academic Article
• Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence  Academic Article
• Point mutations in the melanocortin-4 receptor cause variable obesity in mice  Academic Article
• Polyclonality and multispecificity of the CTL response to a single viral epitope  Academic Article
• Polymorphism within a tcrav family influences the repertoire through class i/ii restriction  Academic Article
• Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response  Academic Article
• Positive modulation of ampa receptors increases neurotrophin expression by hippocampal and cortical neurons  Academic Article
• Positive regulation of ltk ph domain function by soluble ip(4)  Academic Article
• Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties  Academic Article
• Posttranscriptional clearance of hepatitis B virus RNA by cytotoxic T lymphocyte-activated hepatocytes  Academic Article
• Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase large is critical for virus binding  Academic Article
• Posttranslational regulation of tcr v alpha allelic exclusion during t cell differentiation  Academic Article
• Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18)  Academic Article
• Potential of small molecule-mediated reprogramming of rod photoreceptors to treat retinitis pigmentosa  Academic Article
• Potential role for padi-mediated histone citrullination in preimplantation development  Academic Article
• Preclinical evaluation of an anti-HCV miRNA cluster for treatment of HCV infection  Academic Article
• Preclinical metabolic changes in mouse prion diseases detected by 1H-nuclear magnetic resonance spectroscopy  Academic Article
• Precursor frequency, nonlinear proliferation, and functional maturation of virus-specific CD4(+) T cells  Academic Article
• Precursor thymocyte proliferation and differentiation are controlled by signals unrelated to the pre-TCR  Academic Article
• Preferential activation of an IL-2 regulatory sequence transgene in TCR gamma delta and NKT cells: subset-specific differences in IL-2 regulation  Academic Article
• Preliminary PET study of F-18-FC119S in normal and Alzheimer's disease models  Academic Article
• Prenatal diethylstilbestrol induces malformation of the external genitalia of male and female mice and persistent second-generation developmental abnormalities of the external genitalia in two mouse strains  Academic Article
• Preparation of functionally active [35S] leptin for mapping its receptors in the brain  Academic Article
• Presynaptic crf(1) receptors mediate the ethanol enhancement of gabaergic transmission in the mouse central amygdala  Academic Article
• Presynaptic delta opioid receptors regulate ethanol actions in central amygdala  Academic Article
• Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model  Academic Article
• Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: Implications for learning and memory  Academic Article
• Primary demyelination in transgenic mice expressing interferon-gamma  Academic Article
• Primary in vitro antibody responses by purified murine B lymphocytes in serum-free defined medium  Academic Article
• Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury  Academic Article
• Principles of cytotoxic T lymphocyte induction and recognition  Academic Article
• Prion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assay  Academic Article
• Prion strain discrimination in cell culture: The cell panel assay  Academic Article
• Prion strain discrimination using luminescent conjugated polymers  Academic Article
• Prion transmission prevented by modifying the beta 2-alpha 2 loop structure of host PrP(C)  Academic Article
• Prion-induced amyloid heart disease with high blood infectivity in transgenic mice  Academic Article
• Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity  Academic Article
• Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database  Academic Article
• Progesterone receptor-mediated up-regulation of transthyretin in preimplantation mouse uterus  Academic Article
• Progression of activity and structural changes in the anterior cingulate cortex during remote memory formation  Academic Article
• Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins  Academic Article
• Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon  Academic Article
• Prolongation of cardiac allograft survival using dendritic cells treated with NF-kappa B decoy oligodeoxyribonucleotides  Academic Article
• Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer  Academic Article
• Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury  Academic Article
• Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice  Academic Article
• Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic-cells transduced with a retrovirus carrying the hIL-1ra cDNA  Academic Article
• Promyelocytic Leukemia Zinc Finger Turns on the Effector T Cell Program without Requirement for Agonist TCR Signaling  Academic Article
• Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation  Academic Article
• Propagation of rml prions in mice expressing prp devoid of gpi anchor leads to formation of a novel, stable prion strain  Academic Article
• Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with notch receptor ligation  Academic Article
• Protease-activated receptor (par) 2, but not par1, signaling promotes the development of mammary adenocarcinoma in polyoma middle t mice  Academic Article
• Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity  Academic Article
• Protease-activated receptor-1 signaling by activated protein c in cytokine-perturbed endothelial cells is distinct from thrombin signaling  Academic Article
• Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in ldl receptor-deficient mice  Academic Article
• Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy  Academic Article
• Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid  Academic Article
• Protection of the intestinal mucosa by intraepithelial gamma delta T cells  Academic Article
• Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1  Academic Article
• Protective immunity against human carcinoembryonic antigen (cea) induced by an oral DNA vaccine in cea-transgenic mice  Academic Article
• Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation  Academic Article
• Protein 4.1B suppresses prostate cancer progression and metastasis  Academic Article
• Protein S confers neuronal protection during ischemic/hypoxic injury in mice  Academic Article
• Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity  Academic Article
• Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region  Academic Article
• Protein carbamylation links inflammation, smoking, uremia and atherogenesis  Academic Article
• Protein kinase C η is required for T cell activation and homeostatic proliferation  Academic Article
• Protein kinase C-eta controls CTLA-4-mediated regulatory T cell function  Academic Article
• Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation  Academic Article
• Proteolytic cleavage of a self-antigen following xenobiotic-induced cell death produces a fragment with novel immunogenic properties  Academic Article
• Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria  Academic Article
• Prp expression in b lymphocytes is not required for prion neuroinvasion  Academic Article
• Pseudomonas aeruginosa outer-membrane protein f epitopes are highly immunogenic in mice when expressed an a plant virus  Academic Article
• Pten mutations alter brain growth trajectory and allocation of cell types through elevated β-catenin signaling  Academic Article
• Pulmonary surfactant proteins a and d directly suppress cd3(+)/cd4(+) cell function: Evidence for two shared mechanisms(1)  Academic Article
• Pulsed azidohomoalanine labeling in mammals (PALM) detects changes in liver-specific LKB1 knockout mice  Academic Article
• Purification of a benzo[a]pyrene binding protein by affinity chromatography and photoaffinity labeling  Academic Article
• Qualitative and quantitative requirements for CD4(+) T cell-mediated antiviral protection  Academic Article
• Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain  Academic Article
• Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine  Academic Article
• Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice  Academic Article
• Quantitative in vivo and ex vivo confocal microscopy analysis of corneal cystine crystals in the Ctns(-/-) knockout mouse  Academic Article
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• Quantitative trait loci mapping for cholesterol gallstones in akr/j and c57l/j strains of mice  Academic Article
• R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine  Academic Article
• R7BP modulates opiate analgesia and tolerance but not withdrawal  Academic Article
• RGS expression rate-limits recovery of rod photoresponses  Academic Article
• RGS6/G beta 5 complex accelerates IKaCh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate  Academic Article
• RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis  Academic Article
• Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells  Academic Article
• Rapid activation of astrocyte-specific expression of gfap-lacz transgene by focal injury  Academic Article
• Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition  Academic Article
• Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization  Academic Article
• Rapid generation of potent and tumor-specific cytotoxic T lymphocytes by interleukin 18 using dendritic cells and natural killer cells  Academic Article
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• Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting  Academic Article
• Re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections  Academic Article
• Reactivity of steroid-resistant neonatal thymocytes  Academic Article
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• Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production  Academic Article
• Recapitulation of ivig anti-inflammatory activity with a recombinant igg fc  Academic Article
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• Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury  Academic Article
• Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala  Academic Article
• Reciprocal expression in cd4 or cd8 subsets of different members of the v alpha 11 gene family correlates with sequence polymorphism  Academic Article
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• Recognition of conformational determinants on H-2 by cytolytic T lymphocytes  Academic Article
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• Recombinant adenovirus induces maturation of dendritic cells via an NF-kappa B-dependent pathway  Academic Article
• Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model  Academic Article
• Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration  Academic Article
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• Redirecting effector T cells through their IL-2 receptors  Academic Article
• Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1  Academic Article
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• Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of schizophrenia  Academic Article
• Reduced nnos expression induced by repeated nicotine treatment in mu-opioid receptor knockout mice  Academic Article
• Reduced wheel running and blunted effects of voluntary exercise in LPA(1)-null mice: The importance of assessing the amount of running in transgenic mice studies  Academic Article
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• Regulation of carbohydrate metabolism by the farnesoid x receptor  Academic Article
• Regulation of cell division cycle progression by bcl-2 expression: A potential mechanism for inhibition of programmed cell death  Academic Article
• Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta  Academic Article
• Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists  Academic Article
• Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor alpha (ror alpha)  Academic Article
• Regulation of feeding by galnon  Academic Article
• Regulation of hepcidin transcription by interleukin-1 and interleukin-6  Academic Article
• Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase  Academic Article
• Regulation of macrophage migration by a novel plasminogen receptor Plg-R(KT)  Academic Article
• Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta  Academic Article
• Regulation of osteoclast differentiation and function by the CaMK-CREB pathway  Academic Article
• Regulation of pyruvate dehydrogenase kinase expression by the farnesoid x receptor  Academic Article
• Regulation of the B cell receptor repertoire and self-reactivity by BAFF  Academic Article
• Regulation of thymus size by competition for stromal niches among early T cell progenitors  Academic Article
• Regulation of tissue factor gene expression in obesity  Academic Article
• Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia  Academic Article
• Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific cd8(+) t cells  Academic Article
• Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects  Academic Article
• Repertoire-based selection into the marginal zone compartment during B cell development  Academic Article
• Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries  Academic Article
• Replication of dengue and junin viruses in cultured rabbit and human endothelial cells  Academic Article
• Reprogramming of antiviral t cells prevents inactivation and restores t cell activity during persistent viral infection  Academic Article
• Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy  Academic Article
• Requirement for the lPA1 lysophosphatidic acid receptor gene in normal suckling behavior  Academic Article
• Resisting viral infection: the gene by gene approach  Academic Article
• Response and recovery in the plasma metabolome tracks the acute LCMV-induced immune response  Academic Article
• Responses of endothelial cell and astrocyte matrix-integrin receptors to ischemia mimic those observed in the neurovascular unit  Academic Article
• Responses of microRNAs 124a and 223 following spinal cord injury in mice  Academic Article
• Restricted feeding-induced sleep, activity, and body temperature changes in normal and preproghrelin-deficient mice  Academic Article
• Restricted v-segment usage in t-cell receptors from cytotoxic lymphocytes-t specific for a major epitope of lymphocytic choriomeningitis virus  Academic Article
• Retinal TrkB receptors regulate neural development in the inner, but not outer, retina  Academic Article
• Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice  Academic Article
• Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival  Academic Article
• Rev-erb regulation of cholesterologenesis  Academic Article
• Reversal of obesity and insulin resistance by a non-peptidic glucagon-like peptide-1 receptor agonist in diet-induced obese mice  Academic Article
• Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity  Academic Article
• Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease  Academic Article
• Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration  Academic Article
• Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells  Academic Article
• Role of cyclin kinase inhibitor p21 in systemic autoimmunity  Academic Article
• Role of endocannabinoids in alcohol consumption and intoxication: Studies of mice lacking fatty acid amide hydrolase  Academic Article
• Role of galanin receptor 1 and galanin receptor 2 activation in synaptic plasticity associated with 3 ',5 '-cyclic amp response element-binding protein phosphorylation in the dentate gyrus: Studies with a galanin receptor 2 agonist and galanin receptor 1 knockout mice  Academic Article
• Role of gut macrophages in mice orally contaminated with scrapie or BSE  Academic Article
• Role of immunoproteasome catalytic subunits in the immune response to hepatitis B virus  Academic Article
• Role of leukocyte-specific ldl receptors on plasma lipoprotein cholesterol and atherosclerosis in mice  Academic Article
• Role of par2 in murine pulmonary pseudomonal infection  Academic Article
• Role of passive and adaptive immunity in influencing enterocyte-specific gene expression  Academic Article
• Role of peroxiredoxin-2 in protecting rbcs from hydrogen peroxide-induced oxidative stress  Academic Article
• Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis  Academic Article
• Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: A meal pattern analysis  Academic Article
• Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by reelin signaling mutant mice  Academic Article
• Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide  Academic Article
• Ror alpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways  Academic Article
• Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs  Academic Article
• Ryanodine receptor-2 upregulation and nicotine-mediated plasticity  Academic Article
• S-adenosyl-L-homocysteine hydrolase inactivation curtails ovalbumin-induced immune responses  Academic Article
• S-nitrosylation of matrix metalloproteinases: Signaling pathway to neuronal cell death  Academic Article
• S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells  Academic Article
• S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species  Academic Article
• SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation  Academic Article
• SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells  Academic Article
• SREBP1 contributes to resolution of pro-inflammatory TLR4 signaling by reprogramming fatty acid metabolism  Academic Article
• SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development  Academic Article
• Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway  Academic Article
• Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis  Academic Article
• Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival  Academic Article
• Selection against puma gene expression in myc-driven b-cell lymphomagenesis  Academic Article
• Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice  Academic Article
• Selection of tcr v-alpha by mhc class-ii predicts superantigen reactivity  Academic Article
• Selective N-hydroxyhydantoin carbamate inhibitors of mammalian serine hydrolases  Academic Article
• Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening  Academic Article
• Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects  Academic Article
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• Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice  Academic Article
• Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, lPB3/EDG-3  Academic Article
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• Selective stimulation of t cell subsets with antibody-cytokine immune complexes  Academic Article
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• Thymic selection and adaptability of cytotoxic t-lymphocyte responses in transgenic mice expressing a viral protein in the thymus  Academic Article
• Thymic selection and cell-division  Academic Article
• Thymic selection by a single mhc/peptide ligand produces a semidiverse repertoire of cd4(+) t cells  Academic Article
• Thymic selection by a single mhc/peptide ligand: Autoreactive t cells are low-affinity cells  Academic Article
• Thymic skewing of the cd4/cd8 ratio maps with the t-cell receptor alpha-chain locus  Academic Article
• Thymic t cell development and progenitor localization depend on ccr7  Academic Article
• Thymocyte expression of cathepsin L is essential for NKT cell development  Academic Article
• Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to "holes" in the t cell repertoire  Academic Article
• Thymocyte stimulation by anti-tcr-beta, but not by anti-tcr-alpha, leads to induction of developmental transcription program  Academic Article
• Tid1 is required for T cell transition from double-negative 3 to double-positive stages  Academic Article
• Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor 1(2)tid, is critical for early embryonic development and cell survival  Academic Article
• Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons  Academic Article
• Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression  Academic Article
• Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges  Academic Article
• Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet  Academic Article
• Tissue distribution and regulation of murine von Willebrand factor gene expression in vivo  Academic Article
• Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice  Academic Article
• Tissue distribution of factor VIII gene expression in vivo: a closer look  Academic Article
• Tissue factor expression during human and mouse development  Academic Article
• Tissue factor gene expression in the adipose tissues of obese mice  Academic Article
• Tissue factor prothrombotic activity is regulated by integrin-arf6 trafficking  Academic Article
• Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation  Academic Article
• Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage  Academic Article
• Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model - studies in tPA-deficient mice and wild-type mice on a matched genetic background  Academic Article
• Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice  Academic Article
• Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C  Academic Article
• Tissue- and epitope-specific mechanisms account for the diverse effects of anti-CD44 antibodies on the maintenance of primitive hematopoietic progenitors in vitro  Academic Article
• Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment  Academic Article
• Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization  Academic Article
• Tissue-specific regulation of p38α-mediated inflammation in Con A-induced acute liver damage  Academic Article
• Tlr2 is constitutively expressed within the kidney and participates in ischemic renal injury through both myd88-dependent and -independent pathways  Academic Article
• Tlr2 signaling subpathways regulate tlr9 signaling for the effective induction of il-12 upon stimulation by heat-killed brucella abortus  Academic Article
• Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens  Academic Article
• Tolerogenic Nanoparticles Impacting B and T Lymphocyte Responses Delay Autoimmune Arthritis in K/BxN Mice  Academic Article
• Toll-like receptor 4 functions intracellularly in human coronary artery endothelial cells: Roles of lbp and scd14 in mediating lps-responses  Academic Article
• Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection  Academic Article
• Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection  Academic Article
• Toll-like receptors in atherosclerosis  Academic Article
• Topical treatment of basal cell carcinomas in nevoid basal cell carcinoma syndrome with a Smoothened inhibitor  Academic Article
• Topically applied human recombinant monoclonal igg(1) antibody and its fab and f(ab')(2) fragments protect mice from vaginal transmission of hsv-2  Academic Article
• Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon  Academic Article
• Towards understanding the schizophrenia code: an expanded convergent functional genomics approach  Academic Article
• Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease  Academic Article
• Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells  Academic Article
• Transcriptional code and disease map for adult retinal cell types  Academic Article
• Transcriptional control of preadipocyte determination by Zfp423  Academic Article
• Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing  Academic Article
• Transcriptome analysis of sevoflurane exposure effects at the different brain regions  Academic Article
• Transduction of a marker gene (Neor) into precursor cells of the hematopoietic microenvironment [Article in Russian]  Academic Article
• Transduction of dendritic cells with Bcl-xL increases their resistance to prostate cancer-induced apoptosis and antitumor effect in mice  Academic Article
• Transfer of a prion strain to different hosts leads to emergence of strain variants  Academic Article
• Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism  Academic Article
• Transgene-driven expression of the doppel protein in purkinje cells causes purkinje cell degeneration and motor impairment  Academic Article
• Transgenic calmodulin-dependent protein kinase ii activation: Dose-dependent effects on synaptic plasticity, learning, and memory  Academic Article
• Transgenic mice expressing human hla and cd8 molecules generate hla-restricted measles virus cytotoxic t lymphocytes of the same specificity as humans with natural measles virus infection  Academic Article
• Transgenic mice with a reduced core body temperature have an increased life span  Academic Article
• Transgenic overexpression of interleukin-1 receptor antagonist in the CNS influences behaviour, serum corticosterone and brain monoamines  Academic Article
• Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cells  Academic Article
• Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy  Academic Article
• Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein  Academic Article
• Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT  Academic Article
• Transplant-induced reactivation of murine cytomegalovirus immediate early gene expression is associated with recruitment of NF-κB and AP-1 to the major immediate early promoter  Academic Article
• Transplantation of virally transduced cells into the dermis of immunocompetent and immunodeficient (SCID) mice to determine gene expression profile and differential donor cell survival  Academic Article
• Treatment of hind limb ischemia using angiogenic peptide nanofibers  Academic Article
• Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses  Academic Article
• Treatment of severe hypercholesterolemia in apolipoprotein e-deficient mice by bone-marrow transplantation  Academic Article
• Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice  Academic Article
• Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection  Academic Article
• Trif is not required for immune complex glomerulonephritis: Dying cells activate mesangial cells via tlr2/myd88 rather than tlr3/trif  Academic Article
• Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state  Academic Article
• TrkB receptor controls striatal formation by regulating the number of newborn striatal neurons  Academic Article
• Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle  Academic Article
• Tumor necrosis factor alpha and interleukin 1 alpha induce anchorage independence in v-jun transgenic murine cells  Academic Article
• Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease  Academic Article
• Tumor suppressor protein (p)53, is a regulator of NF-kappa B repression by the glucocorticoid receptor  Academic Article
• Tumor-necrosis-factor-alpha and interleukin-1-alpha enhance glucose-utilization by astrocytes - involvement of phospholipase a(2)  Academic Article
• Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses  Academic Article
• Two Sides of a Coin: a Zika Virus Mutation Selected in Pregnant Rhesus Macaques Promotes Fetal Infection in Mice but at a Cost of Reduced Fitness in Nonpregnant Macaques and Diminished Transmissibility by Vectors  Academic Article
• Two distinct but overlapping antibody binding sites in the pre-S(2) region of HBsAg localized within 11 continuous residues  Academic Article
• Two subsets of epithelial cells in the thymic medulla  Academic Article
• Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury  Academic Article
• Type 1 plasminogen activator inhibitor gene expression following partial hepatectomy  Academic Article
• Type C botulinum toxin causes degeneration of motoneurons in vivo  Academic Article
• Type I and type II interferon coordinately regulate suppressive dendritic cell fate and function during viral persistence  Academic Article
• Type I interferon is a therapeutic target for virus-induced lethal vascular damage  Academic Article
• Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection  Academic Article
• UNC93B1 mediates host resistance to infection with Toxoplasma gondii  Academic Article
• Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production  Academic Article
• Ultrastructural localization of cellular prion protein (prpc) at the neuromuscular junction  Academic Article
• Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice  Academic Article
• Unc93b1 biases toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against rna-sensing  Academic Article
• Unexpected autoantibody production in membrane ig-mu-deficient/lpr mice  Academic Article
• Unifying model for molecular determinants of the preselection Vβ repertoire  Academic Article
• Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents  Academic Article
• Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model  Academic Article
• Unique uterine localization and regulation may differentiate LPA3 from other lysophospholipid receptors for its role in embryo implantation  Academic Article
• Unrestricted recognition of a nonpeptide antigen by CD8+ cytolytic T lymphocytes  Academic Article
• Up-regulation of surface-markers on dying thymocytes  Academic Article
• Upregulation of fibronectin and the α5β1 and αvβ3 integrins on blood vessels within the cerebral ischemic penumbra  Academic Article
• Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis  Academic Article
• Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior  Academic Article
• Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm  Academic Article
• Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse  Academic Article
• Use of a high-affinity peptide that aborts mhc-restricted cytotoxic t lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo  Academic Article
• Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling  Academic Article
• Using injectoporation to deliver genes to mechanosensory hair cells  Academic Article
• Using recombinant coxsackievirus b3 to evaluate the induction and protective efficacy of cd8(+) t cells during picornavirus infection  Academic Article
• V alpha 3.2 selection in mhc class i mutant mice - evidence for an alternate orientation of tcr-mhc class i interaction  Academic Article
• V-beta gene repertoires in t-cells expanded in local self-healing and lethal systemic murine cutaneous leishmaniasis  Academic Article
• VBP15, a novel anti-inflammatory, is effective at reducing the severity of murine experimental autoimmune encephalomyelitis  Academic Article
• VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses  Academic Article
• VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation  Academic Article
• Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope  Academic Article
• Vaccination protects beta(2) microglobulin deficient mice from immune mediated mortality but not from persisting viral infection  Academic Article
• Vascular endothelial growth factor receptor 2-based DNA immunization delays development of herpetic stromal keratitis by antiangiogenic effects  Academic Article
• Velvet, a dominant egfr mutation that causes wavy hair and defective eyelid development in mice  Academic Article
• Versatile strategy for controlling the specificity and activity of engineered T cells  Academic Article
• Vesicular stomatitis virus glycoprotein g activates a specific antiviral toll-like receptor 4-dependent pathway  Academic Article
• Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein  Academic Article
• Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: Evidence for involvement of genetically modified dendritic cells and macrophages  Academic Article
• Viral cross talk: Intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver  Academic Article
• Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease  Academic Article
• Viral interleukin-10 (IL-10), the human herpes-virus-4 cellular IL-10 homolog, induces local anergy to allogeneic and syngeneic tumors  Academic Article
• Viral nanoparticles associate with regions of inflammation and blood brain barrier disruption during CNS infection  Academic Article
• Viral rna induces type i interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5 implications for viral infection-associated glomerulonephritis  Academic Article
• Viral targeting of hematopoietic progenitors and inhibition of dc maturation as a dual strategy for immune subversion  Academic Article
• Virus specificity of cytotoxic T lymphocytes generated during acute lymphocytic choriomeningitis virus infection: role of the H-2 region in determining cross-reactivity for different lymphocytic choriomeningitis virus strains  Academic Article
• Virus-induced immune complex disease: genetic control of C1q binding complexes in the circulation of mice persistently infected with lymphocytic choriomeningitis virus  Academic Article
• Virus-induced immunosuppression .1. Age at infection relates to a selective or generalized defect  Academic Article
• Visualization of the genesis and fate of isotype-switched b cells during a primary immune response  Academic Article
• Visualizing cold spots: TRPM8-expressing sensory neurons and their projections  Academic Article
• Visualizing the viral burden: Phenotypic and functional alterations of t cells and apcs during persistent infection  Academic Article
• Vitronectin gene expression in vivo. Evidence for extrahepatic synthesis and acute phase regulation  Academic Article
• Voronoi binding site model of a polycyclic aromatic hydrocarbon binding protein  Academic Article
• Weight-loss in obese mice persistently infected with lymphocytic choriomeningitis virus is not associated with elevated tumor necrosis factor cachectin activity in peritoneal-macrophages  Academic Article
• Whole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration  Academic Article
• Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes  Academic Article
• Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo  Academic Article
• Wiring and molecular features of prefrontal ensembles representing distinct experiences  Academic Article
• X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C  Academic Article
• Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone BXSB mice  Academic Article
• ZBTB1 is a determinant of lymphoid development  Academic Article
• Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice  Academic Article
• betaCaMKII in lateral habenula mediates core symptoms of depression  Academic Article
• delta BAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models  Academic Article
• mu-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche  Academic Article
• rAAV9 combined with renal vein injection is optimal for kidney-targeted gene delivery: conclusion of a comparative study  Academic Article
• Δ9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice  Academic Article
• α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss  Academic Article
• α8-integrins are required for hippocampal long-term potentiation but not for hippocampal-dependent learning  Academic Article
• β-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB₁ or CB₂ receptors  Academic Article