subject area of
- 2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one Derivatives as Potent and Selective Histamine-3 Receptor Antagonists Academic Article
- A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity Academic Article
- A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates Academic Article
- ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion Academic Article
- Antibodies against cd14 protect primates from endotoxin-induced shock Academic Article
- Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys Academic Article
- Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor Academic Article
- Atypical BSE (BASE) transmitted from asymptomatic aging cattle to a primate Academic Article
- B cell recognition of the conserved hiv-1 co-receptor binding site is altered by endogenous primate cd4 Academic Article
- Brain and plasma kinetics of the opioid 11c-hydromorphone in 2 macaque species Academic Article
- Carboxyfullerene neuroprotection postinjury in Parkinsonian nonhuman primates Academic Article
- Characterization of H7N9 influenza A viruses isolated from humans Academic Article
- Chemical generation of bispecific antibodies Academic Article
- Coupling of receptors in brain membranes by fusion to the adenylate-cyclase system of a foreign effector cell Academic Article
- Cta1-dd adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization Academic Article
- DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues Academic Article
- Dietary fish oil-induced decrease in low-density-lipoprotein binding to fibroblasts is mediated by apolipoprotein-e Academic Article
- Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system Academic Article
- Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection Academic Article
- Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients Academic Article
- Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties Academic Article
- Distribution of enkephalin and its relation to serotonin in cat and monkey spinal-cord and brain-stem Academic Article
- Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination Academic Article
- Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma Academic Article
- Evidence for coexistence between calcitonin gene-related peptide and serotonin in the bulbospinal pathway in the monkey Academic Article
- Expression of small cytoplasmic transcripts of the rat identifier element in vivo and in cultured cells Academic Article
- GNE-781, a highly advanced potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein, binding protein (CBP) Academic Article
- Galanin inhibits the potassium-evoked release of acetylcholine and the muscarinic receptor-mediated stimulation of phosphoinositide turnover in slices of monkey hippocampus Academic Article
- Human immunodeficiency virus type 1 env trimer immunization of macaques and impact of priming with viral vector or stabilized core protein Academic Article
- Humanized IgG(1) variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates Academic Article
- Impaired anticoagulant response to infusion of thrombin in atherosclerotic monkeys associated with acquired defects in the protein c system Academic Article
- LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth Academic Article
- Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing Academic Article
- Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor Academic Article
- Patterns of cerebral-cortex messenger-rna expression Academic Article
- Phenol emulsion-enhanced DNA-driven subtractive cdna cloning - isolation of low-abundance monkey cortex-specific messenger-rnas Academic Article
- Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1- (2,4-dimethyl-3-pyridinyl)carbonyl -4-methyl-4- 3(S)-methyl-4- 1(S)- 4-(trifluoro-methyl)phenyl ethyl -1-piperazinyl -piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist Academic Article
- Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1- (4,6-dimethyl-5-pyrimidinyl)carbonyl -4- 4-{2-methoxy-1(R)-4-(trifluo romethyl)-phenyl}ethyl-3(S)-methyl-1-piperazinyl -4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist Academic Article
- Platelet factor 4 enhances generation of activated protein C in vitro and in vivo Academic Article
- PrP(TSE) distribution in a primate model of variant, sporadic, and iatrogenic Creutzfeldt-Jakob disease Academic Article
- Preclinical disposition and pharmacokinetics-pharmacodynamic modeling of biomarker response and tumour growth inhibition in xenograft mouse models of G-573, a MEK inhibitor Academic Article
- Preclinical evaluation in nonhuman primates of murine monoclonal anti-idiotype antibody that mimics the disialoganglioside gd2 Academic Article
- Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke Academic Article
- Raxibacumab for the treatment of inhalational anthrax Academic Article
- Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia Academic Article
- Risk of oral infection with bovine spongiform encephalopathy agent in primates Academic Article
- Synaptic organization of serotonin-immunoreactive fibers in primary visual-cortex of the macaque monkey Academic Article
- Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists Academic Article
- Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth Academic Article
- The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans Academic Article
- The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies Academic Article
- The rational design of selective benzoxazepin inhibitors of the α-isoform of phosphoinositide 3-kinase culminating in the identification of (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo f imidazo 1,2-d 1,4 oxazepin-9-yl)oxy)propanamide (GDC-0326) Academic Article
- The relationship of glucokinase activator-induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studies Academic Article
- Tissue distribution of bovine spongiform encephalopathy agent in primates after intravenous or oral infection Academic Article