subject area of

• A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d  Academic Article
• A glycoengineered enzyme with multiple mannose-6-phosphates is internalized into diseased cells to restore its activity in lysosomes  Academic Article
• A potent and specific immunotoxin for tumor-cells expressing disialoganglioside gd2  Academic Article
• A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells  Academic Article
• A variable cytoplasmic domain segment is necessary for γ-protocadherin trafficking and tubulation in the endosome/lysosome pathway  Academic Article
• AP-2-containing clathrin coats assemble on mature lysosomes  Academic Article
• Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency  Academic Article
• Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense  Academic Article
• Assembly and transport of MHC class II molecules  Academic Article
• Attack of sea-urchin eggs by dogfish phagocytes - model of phagocyte-mediated cellular cytotoxicity  Academic Article
• Beta(2)-adrenergic receptor down-regulation - evidence for a pathway that does not require endocytosis  Academic Article
• Cd4(+) t cells induced by a DNA vaccine: Immunological consequences of epitope-specific lysosomal targeting  Academic Article
• Cell Biology. The proteome in balance  Academic Article
• Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice  Academic Article
• Chemical chaperones increase the cellular activity of N370S beta-glucosidase: a therapeutic strategy for Gaucher disease  Academic Article
• Chlamydia species-dependent differences in the growth requirement for lysosomes  Academic Article
• Chmp5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis  Academic Article
• Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease  Academic Article
• Cystinosin, the protein defective in cystinosis, is a h+-driven lysosomal cystine transporter  Academic Article
• Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A  Academic Article
• Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death  Academic Article
• Differences in the characteristics of inhibition of lymphocyte stimulation by 25-hydroxycholesterol and by the immunoregulatory serum lipoprotein ldl-in  Academic Article
• Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe  Academic Article
• Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane-a2, a stable analog of thromboxane-a2  Academic Article
• Endoplasmic reticulum Ca(2+) increases enhance mutant glucocerebrosidase proteostasis  Academic Article
• Evaluation of artemisinins for the treatment of acute myeloid leukemia  Academic Article
• Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases  Academic Article
• Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the golgi apparatus  Academic Article
• Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation  Academic Article
• Ganoderma lucidum polysaccharides enhance cd14 endocytosis of lps and promote tlr4 signal transduction of cytokine expression  Academic Article
• Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles  Academic Article
• Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction  Academic Article
• Helicobacter pylori induces intracellular galectin-8 aggregation around damaged lysosomes within gastric epithelial cells in a host O-glycan-dependent manner  Academic Article
• Hematopoietic stem cell gene therapy for the multisystemic lysosomal storage disorder cystinosis  Academic Article
• Hsc70 is required for endocytosis and clathrin function in drosophila  Academic Article
• Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis  Academic Article
• Induction of systemic autoimmunity by a xenobiotic requires endosomal TLR trafficking and signaling from the late endosome and endolysosome but not type I IFN  Academic Article
• Inhibiting transthyretin conformational changes that lead to amyloid fibril formation  Academic Article
• Interferon-induced transmembrane protein 3 is a type II transmembrane protein  Academic Article
• Internalization of beta-adrenergic-receptor in a431 cells involves non-coated vesicles  Academic Article
• Intralysosomal cystine accumulation in mice lacking cystinosin, the protein defective in cystinosis  Academic Article
• Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention  Academic Article
• Isolation, structure elucidation, and antitumor activity of spirohexenolides A and B  Academic Article
• Leukocyte-induced tissue injury  Academic Article
• Lysosomal glycosphingolipid recognition by NKT cells  Academic Article
• Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alpha GalCer  Academic Article
• Mechanism of Borna disease virus entry into cells  Academic Article
• Mechanism of lymphocytic choriomeningitis virus entry into cells  Academic Article
• Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery  Academic Article
• Molecular pathogenesis of cystinosis: Effect of ctns mutations on the transport activity and subcellular localization of cystinosin  Academic Article
• Novel phosphate modified cathepsin B linkers: improving aqueous solubility and enhancing payload scope of ADCs  Academic Article
• O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors  Academic Article
• Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function  Academic Article
• Osmiophilic polymer generation: Catalysis by transition metal compounds in ultrastructural cytochemistry  Academic Article
• Peroxisomal ghosts are intracellular structures distinct from lysosomal compartments in Zellweger Syndrome: A confocal laser scanning microscopy study  Academic Article
• Preimplantation diagnosis of a lysosomal storage disorder by in situ enzymatic activity: 'Proof of principle' in acid sphingomyelinase-deficient mice  Academic Article
• Prostacyclin - potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia  Academic Article
• Rab9 GTPase regulates late endosome size and requires effector interaction for its stability  Academic Article
• Rapid analytical and preparative isolation of functional endosomes by free-flow electrophoresis  Academic Article
• Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal-enzymes in mammalian-cells  Academic Article
• Role of lipid trimming and cd1 groove size in cellular antigen presentation  Academic Article
• SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells  Academic Article
• Structure of spleen in idiopathic thrombocytopenic purpura  Academic Article
• Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids  Academic Article
• Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties  Academic Article
• Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation  Academic Article
• Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis  Academic Article
• The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis  Academic Article
• The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1 beta under acidic extracellular pH in LPS-primed microglial cells  Academic Article
• The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death  Academic Article
• The clustered protocadherin endolysosomal trafficking motif mediates cytoplasmic association  Academic Article
• The metabolism of glycosaminoglycans is impaired in prion diseases  Academic Article
• The pilus-induced ca2+ flux triggers lysosome exocytosis and increases the amount of lamp1 accessible to neisseria iga1 protease  Academic Article
• The polyamine oxidase inhibitor mdl-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects  Academic Article
• The prespore vesicles of dictyostelium discoideum - purification, characterization, and developmental regulation  Academic Article
• The role of h2-o and hla-do in major histocompatibility complex class ii-restricted antigen processing and presentation  Academic Article
• The role of negative charge in the delivery of quantum dots to neurons  Academic Article
• The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif  Academic Article
• The tyrosine kinase inhibitor gefitinib restricts mycobacterium tuberculosis growth through increased lysosomal biogenesis and modulation of cytokine signaling  Academic Article
• Thymocyte expression of cathepsin L is essential for NKT cell development  Academic Article
• Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes  Academic Article
• Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis  Academic Article
• mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide  Academic Article