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Lysosomes

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  • A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d  Academic Article
  • A glycoengineered enzyme with multiple mannose-6-phosphates is internalized into diseased cells to restore its activity in lysosomes  Academic Article
  • A potent and specific immunotoxin for tumor-cells expressing disialoganglioside gd2  Academic Article
  • A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells  Academic Article
  • A variable cytoplasmic domain segment is necessary for γ-protocadherin trafficking and tubulation in the endosome/lysosome pathway  Academic Article
  • AP-2-containing clathrin coats assemble on mature lysosomes  Academic Article
  • Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency  Academic Article
  • Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via Fc gamma RIIb on Liver Sinusoidal Endothelial Cells by Endocytosis  Academic Article
  • Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense  Academic Article
  • Assembly and transport of MHC class II molecules  Academic Article
  • Attack of sea-urchin eggs by dogfish phagocytes - model of phagocyte-mediated cellular cytotoxicity  Academic Article
  • Beta(2)-adrenergic receptor down-regulation - evidence for a pathway that does not require endocytosis  Academic Article
  • Cd4(+) t cells induced by a DNA vaccine: Immunological consequences of epitope-specific lysosomal targeting  Academic Article
  • Cell Biology. The proteome in balance  Academic Article
  • Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice  Academic Article
  • Chemical chaperones increase the cellular activity of N370S beta-glucosidase: a therapeutic strategy for Gaucher disease  Academic Article
  • Chlamydia species-dependent differences in the growth requirement for lysosomes  Academic Article
  • Chmp5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis  Academic Article
  • Clinical Antiviral Drug Arbidol Inhibits Infection by SARS-CoV-2 and Variants through Direct Binding to the Spike Protein  Academic Article
  • Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease  Academic Article
  • Cystinosin, the protein defective in cystinosis, is a h+-driven lysosomal cystine transporter  Academic Article
  • Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A  Academic Article
  • Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death  Academic Article
  • Differences in the characteristics of inhibition of lymphocyte stimulation by 25-hydroxycholesterol and by the immunoregulatory serum lipoprotein ldl-in  Academic Article
  • Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe  Academic Article
  • Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane-a2, a stable analog of thromboxane-a2  Academic Article
  • Endoplasmic reticulum Ca(2+) increases enhance mutant glucocerebrosidase proteostasis  Academic Article
  • Evaluation of artemisinins for the treatment of acute myeloid leukemia  Academic Article
  • Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases  Academic Article
  • Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the golgi apparatus  Academic Article
  • Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation  Academic Article
  • Ganoderma lucidum polysaccharides enhance cd14 endocytosis of lps and promote tlr4 signal transduction of cytokine expression  Academic Article
  • Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles  Academic Article
  • Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction  Academic Article
  • Helicobacter pylori induces intracellular galectin-8 aggregation around damaged lysosomes within gastric epithelial cells in a host O-glycan-dependent manner  Academic Article
  • Hematopoietic stem cell gene therapy for the multisystemic lysosomal storage disorder cystinosis  Academic Article
  • Hsc70 is required for endocytosis and clathrin function in drosophila  Academic Article
  • IFITM3 directly engages and shuttles incoming virus particles to lysosomes  Academic Article
  • Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis  Academic Article
  • Induction of systemic autoimmunity by a xenobiotic requires endosomal TLR trafficking and signaling from the late endosome and endolysosome but not type I IFN  Academic Article
  • Inhibiting transthyretin conformational changes that lead to amyloid fibril formation  Academic Article
  • Interferon-induced transmembrane protein 3 is a type II transmembrane protein  Academic Article
  • Internalization of beta-adrenergic-receptor in a431 cells involves non-coated vesicles  Academic Article
  • Intralysosomal cystine accumulation in mice lacking cystinosin, the protein defective in cystinosis  Academic Article
  • Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention  Academic Article
  • Isolation, structure elucidation, and antitumor activity of spirohexenolides A and B  Academic Article
  • Leukocyte-induced tissue injury  Academic Article
  • Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation  Academic Article
  • Lysosomal glycosphingolipid recognition by NKT cells  Academic Article
  • Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alpha GalCer  Academic Article
  • Mechanism of Borna disease virus entry into cells  Academic Article
  • Mechanism of lymphocytic choriomeningitis virus entry into cells  Academic Article
  • Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery  Academic Article
  • Molecular pathogenesis of cystinosis: Effect of ctns mutations on the transport activity and subcellular localization of cystinosin  Academic Article
  • Novel phosphate modified cathepsin B linkers: improving aqueous solubility and enhancing payload scope of ADCs  Academic Article
  • O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors  Academic Article
  • Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function  Academic Article
  • Osmiophilic polymer generation: Catalysis by transition metal compounds in ultrastructural cytochemistry  Academic Article
  • Peroxisomal ghosts are intracellular structures distinct from lysosomal compartments in Zellweger Syndrome: A confocal laser scanning microscopy study  Academic Article
  • Preimplantation diagnosis of a lysosomal storage disorder by in situ enzymatic activity: 'Proof of principle' in acid sphingomyelinase-deficient mice  Academic Article
  • Prostacyclin - potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia  Academic Article
  • Rab9 GTPase regulates late endosome size and requires effector interaction for its stability  Academic Article
  • Rapid analytical and preparative isolation of functional endosomes by free-flow electrophoresis  Academic Article
  • Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy  Academic Article
  • Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal-enzymes in mammalian-cells  Academic Article
  • Role of lipid trimming and cd1 groove size in cellular antigen presentation  Academic Article
  • SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells  Academic Article
  • Site-Specific Lipidation Enhances IFITM3 Membrane Interactions and Antiviral Activity  Academic Article
  • Structure of spleen in idiopathic thrombocytopenic purpura  Academic Article
  • Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids  Academic Article
  • Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties  Academic Article
  • Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation  Academic Article
  • Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis  Academic Article
  • The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis  Academic Article
  • The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules  Academic Article
  • The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1 beta under acidic extracellular pH in LPS-primed microglial cells  Academic Article
  • The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death  Academic Article
  • The clustered protocadherin endolysosomal trafficking motif mediates cytoplasmic association  Academic Article
  • The metabolism of glycosaminoglycans is impaired in prion diseases  Academic Article
  • The pilus-induced ca2+ flux triggers lysosome exocytosis and increases the amount of lamp1 accessible to neisseria iga1 protease  Academic Article
  • The polyamine oxidase inhibitor mdl-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects  Academic Article
  • The prespore vesicles of dictyostelium discoideum - purification, characterization, and developmental regulation  Academic Article
  • The role of h2-o and hla-do in major histocompatibility complex class ii-restricted antigen processing and presentation  Academic Article
  • The role of negative charge in the delivery of quantum dots to neurons  Academic Article
  • The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif  Academic Article
  • The tyrosine kinase inhibitor gefitinib restricts mycobacterium tuberculosis growth through increased lysosomal biogenesis and modulation of cytokine signaling  Academic Article
  • Thymocyte expression of cathepsin L is essential for NKT cell development  Academic Article
  • Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes  Academic Article
  • Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis  Academic Article
  • mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide  Academic Article

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