subject area of
- A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d Academic Article
- A glycoengineered enzyme with multiple mannose-6-phosphates is internalized into diseased cells to restore its activity in lysosomes Academic Article
- A potent and specific immunotoxin for tumor-cells expressing disialoganglioside gd2 Academic Article
- A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells Academic Article
- A variable cytoplasmic domain segment is necessary for γ-protocadherin trafficking and tubulation in the endosome/lysosome pathway Academic Article
- AP-2-containing clathrin coats assemble on mature lysosomes Academic Article
- Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency Academic Article
- Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via Fc gamma RIIb on Liver Sinusoidal Endothelial Cells by Endocytosis Academic Article
- Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense Academic Article
- Assembly and transport of MHC class II molecules Academic Article
- Attack of sea-urchin eggs by dogfish phagocytes - model of phagocyte-mediated cellular cytotoxicity Academic Article
- Beta(2)-adrenergic receptor down-regulation - evidence for a pathway that does not require endocytosis Academic Article
- Cd4(+) t cells induced by a DNA vaccine: Immunological consequences of epitope-specific lysosomal targeting Academic Article
- Cell Biology. The proteome in balance Academic Article
- Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice Academic Article
- Chemical chaperones increase the cellular activity of N370S beta-glucosidase: a therapeutic strategy for Gaucher disease Academic Article
- Chlamydia species-dependent differences in the growth requirement for lysosomes Academic Article
- Chmp5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis Academic Article
- Clinical Antiviral Drug Arbidol Inhibits Infection by SARS-CoV-2 and Variants through Direct Binding to the Spike Protein Academic Article
- Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease Academic Article
- Cystinosin, the protein defective in cystinosis, is a h+-driven lysosomal cystine transporter Academic Article
- Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A Academic Article
- Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death Academic Article
- Differences in the characteristics of inhibition of lymphocyte stimulation by 25-hydroxycholesterol and by the immunoregulatory serum lipoprotein ldl-in Academic Article
- Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe Academic Article
- Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane-a2, a stable analog of thromboxane-a2 Academic Article
- Endoplasmic reticulum Ca(2+) increases enhance mutant glucocerebrosidase proteostasis Academic Article
- Evaluation of artemisinins for the treatment of acute myeloid leukemia Academic Article
- Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases Academic Article
- Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the golgi apparatus Academic Article
- Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation Academic Article
- Ganoderma lucidum polysaccharides enhance cd14 endocytosis of lps and promote tlr4 signal transduction of cytokine expression Academic Article
- Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles Academic Article
- Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction Academic Article
- Helicobacter pylori induces intracellular galectin-8 aggregation around damaged lysosomes within gastric epithelial cells in a host O-glycan-dependent manner Academic Article
- Hematopoietic stem cell gene therapy for the multisystemic lysosomal storage disorder cystinosis Academic Article
- Hsc70 is required for endocytosis and clathrin function in drosophila Academic Article
- IFITM3 directly engages and shuttles incoming virus particles to lysosomes Academic Article
- Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis Academic Article
- Induction of systemic autoimmunity by a xenobiotic requires endosomal TLR trafficking and signaling from the late endosome and endolysosome but not type I IFN Academic Article
- Inhibiting transthyretin conformational changes that lead to amyloid fibril formation Academic Article
- Interferon-induced transmembrane protein 3 is a type II transmembrane protein Academic Article
- Internalization of beta-adrenergic-receptor in a431 cells involves non-coated vesicles Academic Article
- Intralysosomal cystine accumulation in mice lacking cystinosin, the protein defective in cystinosis Academic Article
- Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention Academic Article
- Isolation, structure elucidation, and antitumor activity of spirohexenolides A and B Academic Article
- Leukocyte-induced tissue injury Academic Article
- Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation Academic Article
- Lysosomal glycosphingolipid recognition by NKT cells Academic Article
- Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alpha GalCer Academic Article
- Mechanism of Borna disease virus entry into cells Academic Article
- Mechanism of lymphocytic choriomeningitis virus entry into cells Academic Article
- Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery Academic Article
- Molecular pathogenesis of cystinosis: Effect of ctns mutations on the transport activity and subcellular localization of cystinosin Academic Article
- Novel phosphate modified cathepsin B linkers: improving aqueous solubility and enhancing payload scope of ADCs Academic Article
- O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors Academic Article
- Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function Academic Article
- Osmiophilic polymer generation: Catalysis by transition metal compounds in ultrastructural cytochemistry Academic Article
- Peroxisomal ghosts are intracellular structures distinct from lysosomal compartments in Zellweger Syndrome: A confocal laser scanning microscopy study Academic Article
- Preimplantation diagnosis of a lysosomal storage disorder by in situ enzymatic activity: 'Proof of principle' in acid sphingomyelinase-deficient mice Academic Article
- Prostacyclin - potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia Academic Article
- Rab9 GTPase regulates late endosome size and requires effector interaction for its stability Academic Article
- Rapid analytical and preparative isolation of functional endosomes by free-flow electrophoresis Academic Article
- Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy Academic Article
- Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal-enzymes in mammalian-cells Academic Article
- Role of lipid trimming and cd1 groove size in cellular antigen presentation Academic Article
- SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells Academic Article
- Site-Specific Lipidation Enhances IFITM3 Membrane Interactions and Antiviral Activity Academic Article
- Structure of spleen in idiopathic thrombocytopenic purpura Academic Article
- Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids Academic Article
- Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties Academic Article
- Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation Academic Article
- Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis Academic Article
- The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis Academic Article
- The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules Academic Article
- The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1 beta under acidic extracellular pH in LPS-primed microglial cells Academic Article
- The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death Academic Article
- The clustered protocadherin endolysosomal trafficking motif mediates cytoplasmic association Academic Article
- The metabolism of glycosaminoglycans is impaired in prion diseases Academic Article
- The pilus-induced ca2+ flux triggers lysosome exocytosis and increases the amount of lamp1 accessible to neisseria iga1 protease Academic Article
- The polyamine oxidase inhibitor mdl-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects Academic Article
- The prespore vesicles of dictyostelium discoideum - purification, characterization, and developmental regulation Academic Article
- The role of h2-o and hla-do in major histocompatibility complex class ii-restricted antigen processing and presentation Academic Article
- The role of negative charge in the delivery of quantum dots to neurons Academic Article
- The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif Academic Article
- The tyrosine kinase inhibitor gefitinib restricts mycobacterium tuberculosis growth through increased lysosomal biogenesis and modulation of cytokine signaling Academic Article
- Thymocyte expression of cathepsin L is essential for NKT cell development Academic Article
- Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes Academic Article
- Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis Academic Article
- mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide Academic Article