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  • 13C NMR studies of the product complex of glyoxalase I  Academic Article
  • 2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations  Academic Article
  • 3D C(CC)H TOCSY experiment for assigning protons and carbons in uniformly 13C- and selectively 2H-labeled RNA  Academic Article
  • A DNA-based cancer vaccine enhances lymphocyte cross talk by engaging the nkg2d receptor  Academic Article
  • A LecA ligand identified from a galactoside-conjugate array inhibits host cell invasion by Pseudomonas aeruginosa  Academic Article
  • A bifunctional molecule that displays context-dependent cellular activity  Academic Article
  • A biomimetic polyketide-inspired approach to small-molecule ligand discovery  Academic Article
  • A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy  Academic Article
  • A chemical approach for detecting sulfenic acid-modified proteins in living cells  Academic Article
  • A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (ppar alpha) versus liver x receptor  Academic Article
  • A chemically induced vaccine strategy for prostate cancer  Academic Article
  • A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPAR gamma partial agonists  Academic Article
  • A cross-strand Trp-Trp pair stabilizes the hPin1 WW domain at the expense of function  Academic Article
  • A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome  Academic Article
  • A designed peptidomimetic agonistic ligand of trka nerve growth factor receptors  Academic Article
  • A dominant-negative peroxisome proliferator-activated receptor gamma (ppar gamma) mutant is a constitutive repressor and inhibits ppar gamma-mediated adipogenesis  Academic Article
  • A five-amino-acid motif in the undefined region of the tlr8 ectodomain is required for species-specific ligand recognition  Academic Article
  • A fluorinated ligand enables room-temperature and regioselective Pd-catalyzed fluorination of aryl triflates and bromides  Academic Article
  • A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking  Academic Article
  • A functional hot spot for antigen recognition in a superagonist TCR/MHC complex  Academic Article
  • A general fragment-based approach to identify and optimize bioactive ligands targeting RNA  Academic Article
  • A global benchmark study using affinity-based biosensors  Academic Article
  • A high-throughput ligand competition binding assay for the androgen receptor and other nuclear receptors  Academic Article
  • A labeled guanidine ligand for studying sweet taste  Academic Article
  • A liquid array platform for the multiplexed analysis of synthetic molecule-protein interactions  Academic Article
  • A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes - crystal structure of human leukocyte antigen (hla)-a1-mage-a1 in complex with fab-hyb3  Academic Article
  • A maltose-binding protein fusion construct yields a robust crystallography platform for MCL1  Academic Article
  • A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands  Academic Article
  • A metallopeptide assembly of the HIV-1 gp41 coiled coil is an ideal receptor in fluorescence detection of ligand binding  Academic Article
  • A molecular basis for no selectivity in soluble guanylate cyclase  Academic Article
  • A molecular model of RGD ligands. Antibody D gene segments that direct specificity for the integrin alpha IIb beta 3  Academic Article
  • A molecular switch regulating transcriptional repression and activation of PPARγ  Academic Article
  • A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity  Academic Article
  • A natural product ligand of the oxysterol receptor, liver x receptor  Academic Article
  • A near-IR uncaging strategy based on cyanine photochemistry  Academic Article
  • A new approach to osmium-catalyzed asymmetric dihydroxylation and aminohydroxylation of olefins  Academic Article
  • A new mechanism of allostery in a G protein-coupled receptor dimer  Academic Article
  • A new spatial structure for the axial methionine observed in cytochrome c5 from pseudomonas-mendocina - correlations with the electronic-structure of heme-c  Academic Article
  • A novel method for analyzing extremely biased agonism at G protein-coupled receptors  Academic Article
  • A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests  Academic Article
  • A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects  Academic Article
  • A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity  Academic Article
  • A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site  Academic Article
  • A phosphoarginine containing peptide as an artificial SH2 ligand  Academic Article
  • A plant-like kinase in plasmodium falciparum regulates parasite egress from erythrocytes  Academic Article
  • A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding  Academic Article
  • A population of murine gamma delta T cells that recognize an inducible MHC class Ib molecule  Academic Article
  • A proximity based general method for identification of ligand and receptor interactions in living cells  Academic Article
  • A review of the human sigma-1 receptor structure  Academic Article
  • A rigid trans-spanning dinitrile ligand  Academic Article
  • A role for rev-erb alpha ligands in the regulation of adipogenesis  Academic Article
  • A role for tcr affinity in regulating naive t cell homeostasis  Academic Article
  • A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280  Academic Article
  • A second endogenous cannabinoid that modulates long-term potentiation  Academic Article
  • A second-generation copper(II)-mediated metallo-DNA-base pair  Academic Article
  • A semiempirical free energy force field with charge-based desolvation  Academic Article
  • A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors  Academic Article
  • A slippery grip  Academic Article
  • A small molecule microarray platform to select RNA internal loop-ligand interactions  Academic Article
  • A sphingosine 1-phosphate receptor 2 selective allosteric agonist  Academic Article
  • A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA  Academic Article
  • A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states  Academic Article
  • A structure-activity study of nociceptin-(1-13)-peptide amide. Synthesis of analogues substituted in positions 0, 1, 3, 4 and 10  Academic Article
  • A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype  Academic Article
  • A tetradentate ligand for the enantioselective Ti(IV)-promoted oxidation of sulfides to sulfoxides: origin of enantioselectivity  Academic Article
  • A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes  Academic Article
  • ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase  Academic Article
  • Ablation of cd22 in ligand-deficient mice restores b cell receptor signaling  Academic Article
  • Accelerated bioorthogonal conjugation: A practical method for the ligation of diverse functional molecules to a polyvalent virus scaffold  Academic Article
  • Acceleration of nucleophilic ch activation by strongly basic solvents  Academic Article
  • Action of RORs and their ligands in (patho)physiology  Academic Article
  • Activation of PPARdelta alters lipid metabolism in db/db mice  Academic Article
  • Activation of protein kinase c by phorbol dibutyrate modulates gaba(a) receptor binding in rat brain slices  Academic Article
  • Activation of the liver x receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy  Academic Article
  • Activators of the nuclear receptor ppar gamma enhance colon polyp formation  Academic Article
  • Adenosine: a partial agonist of the growth hormone secretagogue receptor  Academic Article
  • Adenovirus fiber shaft contains a trimerization element that supports peptide fusion for targeted gene delivery  Academic Article
  • Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling  Academic Article
  • Administration of recombinant p-selectin glycoprotein ligand fc fusion protein suppresses inflammation and neointimal formation in zucker diabetic rat model  Academic Article
  • Affinity-based ranking of ligands for DPP-4 from mixtures  Academic Article
  • Agonist-bound structure of the human P2Y(12) receptor  Academic Article
  • Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence  Academic Article
  • Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors  Academic Article
  • Allosteric inhibition of hypoxia inducible factor-2 with small molecules  Academic Article
  • Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists  Academic Article
  • Altered functional and biochemical response by CD8+ T cells that remain after tolerance  Academic Article
  • Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality  Academic Article
  • Aluminum-catalyzed asymmetric addition of TMSCN to aromatic and aliphatic ketones promoted by an easily accessible and recyclable peptide ligand  Academic Article
  • Amino-acid-sequence, hem-iron coordination geometry and functional-properties of mitochondrial and bacterial c-type cytochromes  Academic Article
  • Amyloid beta-peptide polymerization studied using fluorescence correlation spectroscopy  Academic Article
  • An "orphan" finds a home in NSC regulation  Academic Article
  • An NMR perspective on enzyme dynamics  Academic Article
  • An alkoxide-directed intermolecular 2+2+1 annulation: A three-component coupling reaction for the synthesis of tetrasubstituted alpha,beta,-unsaturated gamma-lactams  Academic Article
  • An alternate binding site for PPARγ ligands  Academic Article
  • An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket  Academic Article
  • An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation  Academic Article
  • An intense form of homeostatic proliferation of naive cd8(+) cells driven by il-2  Academic Article
  • An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification  Academic Article
  • Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries  Academic Article
  • Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes  Academic Article
  • Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies  Academic Article
  • Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes  Academic Article
  • Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity  Academic Article
  • Antagonists of the kappa opioid receptor  Academic Article
  • Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR gamma by Cdk5  Academic Article
  • Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides  Academic Article
  • Antibody domain exchange is an immunological solution to carbohydrate cluster recognition  Academic Article
  • Antibody remodeling - a general-solution to the design of a metal-coordination site in an antibody-binding pocket  Academic Article
  • Anticonvulsant activity of a nonpeptide galanin receptor agonist  Academic Article
  • Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation  Academic Article
  • Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis  Academic Article
  • Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry  Academic Article
  • Application of affinity selection/mass spectrometry to determine the structural isomer of parnafungins responsible for binding polyadenosine polymerase  Academic Article
  • Applications of laser-polarized (129)Xe to biomolecular assays  Academic Article
  • Approaches toward selective inhibition of nitric oxide synthase  Academic Article
  • Aptasensors for biosecurity applications  Academic Article
  • Area specificity and topography of thalamocortical projections are controlled by ephrin/eph genes  Academic Article
  • Arrest of beta-amyloid fibril formation by a pentapeptide ligand  Academic Article
  • Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor  Academic Article
  • Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein  Academic Article
  • Aspartate-transcarbamylase lacking catalytic subunit interactions - study of conformational-changes by uv absorbance and circular-dichroism spectroscopy  Academic Article
  • Assembly of PNA-tagged small molecules, peptides, and carbohydrates onto DNA templates: programming the combinatorial pairing and inter-ligand distance  Academic Article
  • Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1  Academic Article
  • Association of neuronal calcium channels with modular adaptor proteins  Academic Article
  • Asymmetric total syntheses of aspidodasycarpine, lonicerine, and the proposed structure of lanciferine  Academic Article
  • Atherosclerosis induced by endogenous and exogenous toll-like receptor (tlr)1 or tlr6 agonists  Academic Article
  • AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings  Academic Article
  • AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading  Academic Article
  • AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility  Academic Article
  • AutoDock4(Zn): an improved AutoDock force field for small-molecule docking to zinc metalloproteins  Academic Article
  • AutoDockFR: Advances in protein-ligand docking with explicitly specified binding site flexibility  Academic Article
  • Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA  Academic Article
  • Autologous regulation of naive t cell homeostasis within the t cell compartment  Academic Article
  • Automated docking of flexible ligands: applications of AutoDock  Academic Article
  • Automated docking of ligands to an artificial active site: augmenting crystallographic analysis with computer modeling  Academic Article
  • Automated docking to multiple target structures: incorporation of protein mobility and structural water heterogeneity in AutoDock  Academic Article
  • Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase  Academic Article
  • Automated hydrogen/deuterium exchange electron transfer dissociation high resolution mass spectrometry measured at single-amide resolution  Academic Article
  • Automated prediction of ligand-binding sites in proteins  Academic Article
  • Avidity of cd1d-ligand-receptor ternary complex contributes to t-helper 1 (th1) polarization and anticancer efficacy  Academic Article
  • Aza-amino acid scanning of chromobox homolog 7 (CBX7) ligands  Academic Article
  • Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential  Academic Article
  • B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen  Academic Article
  • B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention  Academic Article
  • BRI1 is a critical component of a plasma-membrane receptor for plant steroids  Academic Article
  • Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery  Academic Article
  • Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation  Academic Article
  • Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off rags and promotes B cell-positive selection  Academic Article
  • Benzimidazole and related ligands for Cu-catalyzed azide-alkyne cycloaddition  Academic Article
  • Beyond protein binding: recent advances in screening DNA-encoded libraries  Academic Article
  • Beyond the ligand: extracellular and transcellular G protein-coupled receptor complexes in physiology and pharmacology  Academic Article
  • Biased signaling pathways in betaβ2-adrenergic receptor characterized by 19F-NMR  Academic Article
  • Bicyclic core estrogens as full antagonists: Synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides  Academic Article
  • Bifunctional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells  Academic Article
  • Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells  Academic Article
  • Binding and functional properties of concanavalin-a and its derivatives .3. Interactions with indoleacetic-acid and other hydrophobic ligands  Academic Article
  • Binding of alpha(2)-macroglobulin and limulin: Regulation of the plasma haemolytic system of the american horseshoe crab, limulus  Academic Article
  • Binding of proteins to cnbr-activated sepharose 4b  Academic Article
  • Biochemical and structural analysis of nuclear protein import  Academic Article
  • Biochemistry of soluble guanylate cyclase  Academic Article
  • Biocompatible click chemistry enabled compartment-specific pH measurement inside E-coli  Academic Article
  • Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors  Academic Article
  • Blocking transcription through a nucleosome with synthetic DNA ligands  Academic Article
  • BluB cannibalizes flavin to form the lower ligand of vitamin B-12  Academic Article
  • Blue-fluorescent antibodies  Academic Article
  • Bmp signaling is required for development of primary lens fiber cells  Academic Article
  • Building synthetic antibodies as adhesive ligands for integrins  Academic Article
  • Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase  Academic Article
  • C5L2, a nonsignaling C5A binding protein  Academic Article
  • CCL3L1 and HIV/AIDS susceptibility  Academic Article
  • CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia  Academic Article
  • CD44 receptor unfolding enhances binding by freeing basic amino acids to contact carbohydrate ligand  Academic Article
  • CD8αα and ‐αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I  Academic Article
  • CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase  Academic Article
  • CSI-FID: high throughput label-free detection of DNA binding molecules  Academic Article
  • Carbon-deuterium bonds as probes of dihydrofolate reductase  Academic Article
  • Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis  Academic Article
  • Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: Crystal structures of abzyme 21D8  Academic Article
  • Catalytic and regioselective ring expansion of arylcyclobutanones with trimethylsilyldiazomethane. Ligand-dependent entry to beta-ketosilane or enolsilane adducts  Academic Article
  • Catalyzed oxidative corrosion of porous silicon used as an optical transducer for ligand-receptor interactions  Academic Article
  • Cbp/p300 taz1 domain forms a structured scaffold for ligand binding  Academic Article
  • Cd22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of b cells  Academic Article
  • Cd62 and endothelial-cell leukocyte adhesion molecule-1 (elam-1) recognize the same carbohydrate ligand, sialyl-lewis-x  Academic Article
  • Cell surface biology mediated by low affinity multivalent protein-glycan interactions  Academic Article
  • Cell, isoform, and environment factors shape gradients and modulate chemotaxis  Academic Article
  • Changes in structure and dynamics of the fv fragment of a catalytic antibody upon binding of inhibitor  Academic Article
  • Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry  Academic Article
  • Characterization of pharmacologically active antipeptide antibodies directed against the first and 2nd extracellular loops of the serotonin 5-ht1a receptor  Academic Article
  • Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands  Academic Article
  • Characterization of the structure and function of W -> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding  Academic Article
  • Charting a path to success in virtual screening  Academic Article
  • Chemical approaches to nuclear receptors in metabolism  Academic Article
  • Chemical approaches to the lysophospholipid receptors  Academic Article
  • Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts  Academic Article
  • Chemical fragments as foundations for understanding target space and activity prediction  Academic Article
  • Chemical microarrays to identify ligands that bind pathogenic cells  Academic Article
  • Chemical probes of endocannabinoid metabolism  Academic Article
  • Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer  Academic Article
  • Chemically regulated zinc finger transcription factors  Academic Article
  • Chemistry and molecular biology of galanin receptor ligands  Academic Article
  • Chemoenzymatic synthesis of sialyl-trimeric-Lewis X  Academic Article
  • Chemoproteomic screening of covalent ligands reveals UBA5 as a novel pancreatic cancer target  Academic Article
  • Chemoproteomics reveals Toll-like receptor fatty acylation  Academic Article
  • Chemotype-selective modes of action of κ-opioid receptor agonists  Academic Article
  • Chronic nicotine treatment counteracts dopamine d-2 receptor up-regulation induced by a partial meso-diencephalic hemitransection in the rat  Academic Article
  • Classification of PDZ domains  Academic Article
  • Cloning, expression, and characterization of a nitric oxide synthase protein from deinococcus radiodurans  Academic Article
  • Closely related antibody receptors exploit fundamentally different strategies for steroid recognition  Academic Article
  • Coexpression of beta-1-adrenergic and beta-2-adrenergic receptors on bovine brain capillary endothelial-cells in culture  Academic Article
  • Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis  Academic Article
  • Combinatorial chemistry: A liquid-phase approach  Academic Article
  • Commensal bacteria make GPCR ligands that mimic human signalling molecules  Academic Article
  • Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008  Academic Article
  • Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus  Academic Article
  • Comparison of intra- vs intermolecular long-range electron transfer in crystals of ruthenium-modified azurin  Academic Article
  • Computational fragment-based binding site identification by ligand competitive saturation  Academic Article
  • Computational functional group mapping for drug discovery  Academic Article
  • Computational protein-ligand docking and virtual drug screening with the AutoDock suite  Academic Article
  • Conformational changes in aspartate transcarbamylase. II. Circular dichroism evidence for the involvement of metal ions in allosteric interactions  Academic Article
  • Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding  Academic Article
  • Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions  Academic Article
  • Conformational effects in biological catalysis: an antibody-catalyzed oxy-Cope rearrangement  Academic Article
  • Conformational flexibility in the flap domains of ligand-free HIV protease  Academic Article
  • Conformational flexibility of b-DNA at 0.74 Å resolution: D(ccagtactgg)(2)  Academic Article
  • Conformational isomerism can limit antibody catalysis  Academic Article
  • Conformational states of the full-length glucagon receptor  Academic Article
  • Conserved binding mode of human beta(2) adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography  Academic Article
  • Conserved glycine 232 in the ligand channel of ba(3) cytochrome oxidase from Thermus thermophilus  Academic Article
  • Constitutive activity of the melanocortin-4 receptor is maintained by its n-terminal domain and plays a role in energy homeostasis in humans  Academic Article
  • Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c  Academic Article
  • Contemporary paradigms for cholinergic ligand design guided by biological structure  Academic Article
  • Controlling the architecture, coordination, and reactivity of nanoparticle coating utilizing an amino acid central scaffold  Academic Article
  • Cooperative binding of magnesium to transfer ribonucleic acid studied by a fluorescent probe  Academic Article
  • Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22  Academic Article
  • Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies  Academic Article
  • Cortistatin a is a high-affinity ligand of protein kinases rock, cdk8, and cdk11  Academic Article
  • Coumarin derivatives as substrate probes of mammalian cytochromes P450 2B4 and 2B6: assessing the importance of 7-Alkoxy chain length, halogen substitution, and non-active site mutations  Academic Article
  • Coupling of receptor conformation and ligand orientation determine graded activity  Academic Article
  • Covalent and 3-dimensional structure of concanavalin-a .3. Structure of monomer and its interactions with metals and saccharides  Academic Article
  • Covalent docking using autodock: two-point attractor and flexible side chain methods  Academic Article
  • Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products  Academic Article
  • Covalently-linked ligand stabilizes expression of heterodimeric receptor  Academic Article
  • Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling  Academic Article
  • Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex  Academic Article
  • Cryopreservation of postnatal rat retinal ganglion cells: persistence of voltage- and ligand-gated ionic currents  Academic Article
  • Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution  Academic Article
  • Crystal structure of S-adenosylmethionine : tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold  Academic Article
  • Crystal structure of a gamma delta t cell receptor ligand t22: A truncated mhc-like fold  Academic Article
  • Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution  Academic Article
  • Crystal structure of adenosine 5 '-phosphosulfate kinase from Penicillium chrysogenum  Academic Article
  • Crystal structure of antagonist bound human lysophosphatidic acid receptor 1  Academic Article
  • Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening  Academic Article
  • Crystal structure of human cytochrome p450 2d6 with prinomastat bound  Academic Article
  • Crystal structure of human toll-like receptor 3 (tlr3) ectodomain  Academic Article
  • Crystal structure of mouse cd1: An mhc-like fold with a large hydrophobic binding groove  Academic Article
  • Crystal structure of mouse cd1d bound to the self ligand phosphatidylcholine: A molecular basis for nkt cell activation  Academic Article
  • Crystal structure of soluble md-1 and its interaction with lipid iva  Academic Article
  • Crystal structure of the Frizzled 4 receptor in a ligand-free state  Academic Article
  • Crystal structure of the TCR co-receptor CD8 alpha alpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution  Academic Article
  • Crystal structure of the human 4-1BB/4-1BBL complex  Academic Article
  • Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of camp-dependent protein kinase  Academic Article
  • Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892  Academic Article
  • Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor  Academic Article
  • Crystal structures of apolipoprotein(a) kringle iv37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: Existence of novel and expected binding modes  Academic Article
  • Crystal structures of cytochrome p450 2b4 in complex with the inhibitor 1-biphenyl-4-methyl-1h-imidazole: Ligand-induced structural response through alpha-helical repositioning  Academic Article
  • Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands  Academic Article
  • Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain  Academic Article
  • Crystallization of murine major histocompatibility complex class-i h-2kb with single peptides  Academic Article
  • Curariform antagonists bind in different orientations to acetylcholine-binding protein  Academic Article
  • Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins  Academic Article
  • Cutting edge: Trimolecular interaction of tcr with mhc class ii and bacterial superantigen shows a similar affinity to mhc : Peptide ligands  Academic Article
  • Cutting edge: dendritic epidermal gamma delta T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding  Academic Article
  • Cyclic and linear oligocarbamate ligands for human thrombin  Academic Article
  • Cyclin-dependent kinases 5 template: useful for virtual screening  Academic Article
  • Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site  Academic Article
  • Cytokine receptor dimerization and activation: prospects for small molecule agonists  Academic Article
  • Cytotactin and its proteoglycan ligand mark structural and functional boundaries in somatosensory cortex of the early postnatal mouse  Academic Article
  • Cytotoxicity of quantum dots used for in vitro cellular labeling: role of QD surface ligand, delivery modality, cell type, and direct comparison to organic fluorophores  Academic Article
  • DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid  Academic Article
  • DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex  Academic Article
  • DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands  Academic Article
  • DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia  Academic Article
  • DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the nkg2d receptor  Academic Article
  • DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor  Academic Article
  • Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo  Academic Article
  • Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex  Academic Article
  • Defective lymphotoxin-β receptor-induced NF-κB transcriptional activity in NIK-deficient mice  Academic Article
  • Defining the communication between agonist and coactivator binding in the retinoid X receptor alpha ligand binding domain  Academic Article
  • Defining the conditional basis of silicon phthalocyanine near-IR ligand exchange  Academic Article
  • Defining the rna internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis  Academic Article
  • Deletion mutants of human interleukin 1β with significantly reduced agonist properties: Search for the agonist/antagonist switch in ligands to the interleukin 1 receptors  Academic Article
  • Delineation of the peptide binding site of the human galanin receptor  Academic Article
  • Delta(9)-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta(9)-tetrahydrocannabinol  Academic Article
  • Density functional calculation of pKa values and redox potentials in the bovine Rieske iron-sulfur protein  Academic Article
  • Density functional study of a mu-1,1-carboxylate bridged Fe(III)-O-Fe(IV) model complex. 2. Comparison with ribonucleotide reductase intermediate X  Academic Article
  • Derivation of a retinoid x receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1h-indol-3-yl)methyl-4-trifluoromethylbenzene  Academic Article
  • Design and synthesis of a rapamycin-based high-affinity binding fkbp12 ligands  Academic Article
  • Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching  Academic Article
  • Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant  Academic Article
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  • Isolation of protein ligands from large peptoid libraries  Academic Article
  • Iterative in situ click chemistry creates antibody-like protein-capture agents  Academic Article
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  • Kinetic stabilization of an oligomeric protein by a single ligand binding event  Academic Article
  • Kinetic stabilization of the native state by protein engineering: Implications for inhibition of transthyretin amyloidogenesis  Academic Article
  • L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding  Academic Article
  • LCP-Tm: An assay to measure and understand stability of membrane proteins in a membrane environment  Academic Article
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  • Label-free quantification of membrane-ligand interactions using backscattering interferometry  Academic Article
  • Lactonization as a general route to β-C(sp 3)-H functionalization 
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  • Lessons in molecular recognition. 2. Assessing and improving cross-docking accuracy  Academic Article
  • Lessons in molecular recognition: The effects of ligand and protein flexibility on molecular docking accuracy  Academic Article
  • Ligand access to the active site in thermus thermophilus ba(3) and bovine heart aa(3) cytochrome oxidases  Academic Article
  • Ligand accessibility to the HIV-1 Env co-receptor binding site can occur prior to CD4 engagement and is independent of viral tier category  Academic Article
  • Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans  Academic Article
  • Ligand activation of ERRα by cholesterol mediates statin and bisphosphonate effects  Academic Article
  • Ligand and coactivator identity determines the requirement of the charge clamp for coactivation of the peroxisome proliferator-activated receptor gamma  Academic Article
  • Ligand and receptor dynamics contribute to the mechanism of graded PPAR gamma agonism  Academic Article
  • Ligand binding and inhibition of an oxygen-sensitive soluble guanylate cyclase, gyc-88e, from drosophila  Academic Article
  • Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues  Academic Article
  • Ligand control of coregulator recruitment to nuclear receptors  Academic Article
  • Ligand dimerization programmed by hybridization to study multimeric ligand-receptor interactions  Academic Article
  • Ligand discrimination in soluble guanylate cyclase and the h-nox family of heme sensor proteins  Academic Article
  • Ligand profiling and identification technology for searching bioactive ligands  Academic Article
  • Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics  Academic Article
  • Ligand specificity of h-nox domains: From sgc to bacterial no sensors  Academic Article
  • Ligand-accelerated C-H activation reactions: evidence for a switch of mechanism  Academic Article
  • Ligand-accelerated Cu-catalyzed azide-alkyne cycloaddition: a mechanistic report  Academic Article
  • Ligand-accelerated cross-coupling of C(sp2)-H bonds with arylboron reagents  Academic Article
  • Ligand-accelerated ortho-C-H alkylation of arylcarboxylic acids using alkyl boron reagents  Academic Article
  • Ligand-binding dynamics rewire cellular signaling via estrogen receptor-alpha  Academic Article
  • Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening  Academic Article
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  • Ligand-controlled C(sp(3))-H arylation and olefination in synthesis of unnatural chiral alpha-amino acids  Academic Article
  • Ligand-controlled divergent dehydrogenative reactions of carboxylic acids via C-H activation  Academic Article
  • Ligand-dependent coactivation of the human bile acid receptor fxr by the peroxisome proliferator-activated receptor gamma coactivator-1 alpha  Academic Article
  • Ligand-dependent exponential amplification of a self-replicating L-RNA enzyme  Academic Article
  • Ligand-dependent perturbation of the conformational ensemble for the GPCR beta(2) adrenergic receptor revealed by HDX  Academic Article
  • Ligand-dependent regulation of retinoic acid receptor alpha in rat testis: In vivo response to depletion and repletion of vitamin A  Academic Article
  • Ligand-enabled cross-coupling of C(sp(3))-H bonds with arylboron reagents via Pd(II)/Pd(0) catalysis  Academic Article
  • Ligand-enabled cross-coupling of C(sp(3))-H bonds with arylsilanes  Academic Article
  • Ligand-enabled gamma-C-H olefination and carbonylation: construction of beta-quaternary carbon centers  Academic Article
  • Ligand-enabled meta-C-H activation using a transient mediator  Academic Article
  • Ligand-enabled meta-C-H alkylation and arylation using a modified norbornene  Academic Article
  • Ligand-enabled methylene C(sp3)-H bond activation with a Pd(II) catalyst  Academic Article
  • Ligand-enabled reactivity and selectivity in a synthetically versatile aryl C-H olefination  Academic Article
  • Ligand-enabled triple C-H activation reactions: one-pot synthesis of diverse 4-aryl-2-quinolinones from propionamides  Academic Article
  • Ligand-enabled β-C-H arylation of α-amino acids using a simple and practical auxiliary  Academic Article
  • Ligand-enabled γ-C(sp(3))-H olefination of amines: en route to pyrrolidines  Academic Article
  • Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor  Academic Article
  • Ligand-guided receptor optimization  Academic Article
  • Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor  Academic Article
  • Ligand-induced and nonfusogenic dissolution of a viral membrane  Academic Article
  • Ligand-induced conformational changes in the bacillus subtilis chemoreceptor mcpb determined by disulfide crosslinking in vivo  Academic Article
  • Ligand-induced conformational changes observed in single RNA molecules  Academic Article
  • Ligand-induced internalization of the epidermal growth-factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors  Academic Article
  • Ligand-induced protease receptor translocation into caveolae: A mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway  Academic Article
  • Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation  Academic Article
  • Ligand-mediated retargeting of recombinant adenovirus for gene transfer in vivo  Academic Article
  • Ligand-promoted alkylation of C(sp(3))-H and C(sp(2))-H bonds  Academic Article
  • Ligand-promoted borylation of C(sp(3))-H bonds with palladium(II) catalysts  Academic Article
  • Ligand-promoted c-3 selective c-h olefination of pyridines with pd catalysts  Academic Article
  • Ligand-promoted c3-selective arylation of pyridines with pd catalysts: Gram-scale synthesis of (+/-)-preclamol  Academic Article
  • Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms  Academic Article
  • Ligands in crystal structures that aid in functional characterization  Academic Article
  • Ligands in psi structures  Academic Article
  • Ligands of the neuropeptide Y Y2 receptor  Academic Article
  • Ligands specify coactivator nuclear receptor (nr) box affinity for estrogen receptor subtypes  Academic Article
  • Linking high-throughput screens to identify MoAs and novel inhibitors of Mycobacterium tuberculosis dihydrofolate reductase  Academic Article
  • Lipid agonism: The PIP2 paradigm of ligand-gated ion channels  Academic Article
  • Lipophilic regulator of a developmental switch in Caenorhabditis elegans  Academic Article
  • Liver x receptor and retinoic x receptor mediated abca1 regulation and cholesterol efflux in macrophage cells - messenger rna measured by branched DNA technology  Academic Article
  • Lysophospholipid receptor nomenclature review: IUPHAR Review 8  Academic Article
  • Lysophospholipid receptors: signaling and biology  Academic Article
  • Lysosomal glycosphingolipid recognition by NKT cells  Academic Article
  • MDB: The metalloprotein database and browser at The Scripps Research Institute  Academic Article
  • MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist  Academic Article
  • Magnetic circular dichroism spectroscopic characterization of the NOS-like protein from Geobacillus stearothermophilus (gsNOS)  Academic Article
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  • Manipulation of thrombin exosite I, by ligand-directed covalent modification  Academic Article
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  • Mechanism of the ligand-free Cu-I-catalyzed azide-alkyne cycloaddition reaction  Academic Article
  • Mechanism-based profiling of enzyme families  Academic Article
  • Mechanisms and consequences of affinity modulation of integrin alpha(v)beta(3) detected with a novel patch-engineered monovalent ligand  Academic Article
  • Mechanisms imposing the V beta bias of V alpha 14 natural killer T cells and consequences for microbial glycolipid recognition  Academic Article
  • Mechanisms of distribution and targeting of neuronal ion channels  Academic Article
  • Mechanisms of nuclear-protein import  Academic Article
  • Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery  Academic Article
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  • Metal ligand substitution and evidence for quinone formation in taurine/alpha-ketoglutarate dioxygenase  Academic Article
  • Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity  Academic Article
  • Metalloantibodies  Academic Article
  • Methionine ligand interaction in a blue copper protein characterized by site-selective infrared spectroscopy  Academic Article
  • Methodology for protein-ligand binding studies: application to a model for drug resistance, the HIV/FIV protease system  Academic Article
  • Mhc class ii engagement in brain endothelial cells induces protein kinase a-dependent il-6 secretion and phosphorylation of camp response element-binding protein  Academic Article
  • Micro- and nanotechnologies for studying cellular function  Academic Article
  • Mild and general methods for the palladium-catalyzed cyanation of aryl and heteroaryl chlorides  Academic Article
  • Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands  Academic Article
  • Minor groove DNA-protein contacts upstream of a tRNA gene detected with a synthetic DNA binding ligand  Academic Article
  • Mixed-element capture agents: A simple strategy for the construction of synthetic, high-affinity protein capture ligands  Academic Article
  • Model of the alpha L beta 2 integrin I-domain/ICAM-1 DI interface suggests that subtle changes in loop orientation determine ligand specificity  Academic Article
  • Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies  Academic Article
  • Modulating heme redox potential through protein-induced porphyrin distortion  Academic Article
  • Modulation of HIF-2α PAS-B domain contributes to physiological responses  Academic Article
  • Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ib-alpha  Academic Article
  • Molecular behavior in small spaces  Academic Article
  • Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3  Academic Article
  • Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions  Academic Article
  • Molecular control of delta-opioid receptor signalling  Academic Article
  • Molecular determinants of Arg-Gly-Asp ligand specificity for beta(3) integrins  Academic Article
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  • Molecular interactions at the t cell-antigen-presenting cell interface  Academic Article
  • Molecular mechanism for switching of p-falciparum invasion pathways into human erythrocytes  Academic Article
  • Molecular mechanism of lipopeptide presentation by cd1a  Academic Article
  • Molecular recognition of 6 '-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches  Academic Article
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  • Mouse siglec-f and human siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6 '-sulfo-sialyl lewis x as a preferred glycan ligand  Academic Article
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  • Multiple interaction sites of galnon trigger its biological effects  Academic Article
  • Multivalent and multifunctional ligands to β-amyloid  Academic Article
  • Multivalent display and receptor-mediated endocytosis of transferrin on virus-like particles  Academic Article
  • Murine pheromone proteins constitute a context-dependent combinatorial code governing multiple social behaviors  Academic Article
  • Muscarinic acetylcholine receptor  Academic Article
  • Mutagenesis and ligand modification studies on galanin binding to its GTP-binding-protein-coupled receptor GalR1  Academic Article
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  • Mutational analysis of ligand-binding activity of beta-2 adrenergic-receptor expressed in escherichia-coli  Academic Article
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  • N-terminal galanin fragments inhibit the hippocampal release of acetylcholine in vivo  Academic Article
  • NF kappa B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses  Academic Article
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  • NMR solution structure of the inserted domain of human leukocyte function associated antigen-1  Academic Article
  • NMR solution structure of the isolated Apo Pin1 WW domain: comparison to the X-ray crystal structures of Pin1  Academic Article
  • NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor  Academic Article
  • NMR structure of a cyclic polyamide-DNA complex  Academic Article
  • Nanoparticles Displaying Allergen and Siglec-8 Ligands Suppress IgE-FcεRI-Mediated Anaphylaxis and Desensitize Mast Cells to Subsequent Antigen Challenge  Academic Article
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  • Negative regulation of t cell receptor signaling by siglec-7 (p70/airm) and siglec-9  Academic Article
  • Negative regulation of the Apaf-1 apoptosome by Hsp70  Academic Article
  • Negative stain single-particle EM of the maltose transporter in nanodiscs reveals asymmetric closure of MalK2 and catalytic roles of ATP, MalE, and maltose  Academic Article
  • Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease  Academic Article
  • Neuron-glia cell-adhesion molecule interacts with neurons and astroglia via different binding mechanisms  Academic Article
  • Neurotransmitter action - opening of ligand-gated ion channels  Academic Article
  • New catalysts for the asymmetric hydrosilylation of ketones discovered by mass spectrometry screening  Academic Article
  • New chemistry for the study of multiprotein complexes: The six-histidine tag as a receptor for a protein crosslinking reagent  Academic Article
  • New insights into inhibitor design from the crystal structure and NMR studies of escherichia coli GAR and 10-formyl-5,8,10-trideazafolic acid  Academic Article
  • New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling  Academic Article
  • Nibbling at crf receptor control of feeding and gastrocolonic motility  Academic Article
  • Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells  Academic Article
  • Nmr detection of adventitious xylose binding to the quorum-sensing protein SdiA of Escherichia coli  Academic Article
  • Nmr structure of the unliganded bombyx mori pheromone-binding protein at physiological ph  Academic Article
  • Nociceptin/orphanin fq metabolism and bioactive metabolites  Academic Article
  • Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists  Academic Article
  • Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold  Academic Article
  • Novel analogues of (R)-5-(methylamino)-5,6-dihydro-4H-imidazo 4,5,1-ij quinolin-2(1H)-one (sumanirole) provide clues to dopamine D-2/D-3 receptor agonist selectivity  Academic Article
  • Novel approaches for targeting the adenosine A2A receptor  Academic Article
  • Novel galanin receptor ligands  Academic Article
  • Novel lamprey antibody recognizes terminal sulfated galactose epitopes on mammalian glycoproteins  Academic Article
  • Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects  Academic Article
  • Novel pharmacological probes reveal ABHD5 as a locus of lipolysis control in white and brown adipocytess  Academic Article
  • Novel selective allosteric and bitopic ligands for the S1P(3) receptor  Academic Article
  • Novel systemically active galanin receptor 2 ligands in depression-like behavior  Academic Article
  • Nuclear Receptor Chemical Reporter Enables Domain-Specific Analysis of Ligands in Mammalian Cells  Academic Article
  • Nuclear hormone receptors for heme: Rev-erb alpha and rev-erb beta are ligand-regulated components of the mammalian clock  Academic Article
  • Nuclear magnetic resonance studies of a ribonuclease-dinucleoside phosphonate complex and their implications for the mechanism of the enzyme  Academic Article
  • Nuclear receptor ligands and cofactor recruitment: is there a coactivator "on deck"?  Academic Article
  • Nuclear receptors and their selective pharmacologic modulators  Academic Article
  • Nuclear receptors, metabolism, and the circadian clock  Academic Article
  • Nucleic acid encoding to program self-assembly in chemical biology  Academic Article
  • Observation of covalent intermediates in an enzyme mechanism at atomic resolution  Academic Article
  • Observations on the oxidation-reduction properties of bovine erythrocyte superoxide dismutase  Academic Article
  • On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7  Academic Article
  • Open and closed conformations of two SpoiiAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding  Academic Article
  • Opportunities for functional selectivity in gpcr antibodies  Academic Article
  • Optimization of adenosine 5 '-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening  Academic Article
  • Optimization of the magnetic recovery of hits from one-bead-one-compound library screens  Academic Article
  • Optimized protocols for the isolation of specific protein-binding peptides or peptoids from combinatorial libraries displayed on beads  Academic Article
  • Optimized translocator protein ligand for optical molecular imaging and screening  Academic Article
  • Optochemical control of gene expression by photocaged guanine and riboswitches  Academic Article
  • Organocatalytic enantioselective synthesis of metabotropic glutamate receptor ligands  Academic Article
  • Osmolyte-, binding-, and temperature-induced transitions of intrinsically disordered proteins  Academic Article
  • Oxygenation of hydrocarbons by cytochrome-p-450 model compounds - modification of reactivity by axial ligands  Academic Article
  • Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design  Academic Article
  • PNA-encoded chemical libraries  Academic Article
  • Palladium(II)-catalyzed enantioselective C(sp(3))-H activation using a chiral hydroxamic acid ligand  Academic Article
  • Palladium-meta-terarylphosphine catalyst for the Mizoroki-Heck reaction of (hetero)aryl bromides and functional olefins  Academic Article
  • Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding  Academic Article
  • Panning for snurms: Using cofactor profiling for the rational discovery of selective nuclear receptor modulators  Academic Article
  • Paramagnetic proteoliposomes containing a pure, native, and oriented seven-transmembrane segment protein, CCR5  Academic Article
  • Partial agonists activate PPAR gamma using a helix 12 independent mechanism  Academic Article
  • Paying the price for pathogen protection: Toll receptors in atherogenesis  Academic Article
  • Pd(0)/PR(3)-catalzed intermolecular arylation of sp(3) C-H bonds  Academic Article
  • Pd(II)-catalyzed C3-selective arylation of pyridine with (hetero)arenes  Academic Article
  • Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes  Academic Article
  • Pd(II)-catalyzed hydroxyl-directed C-H olefination enabled by monoprotected amino acid ligands  Academic Article
  • Pd(ii)-catalyzed enantioselective activation of c(sp(2))-h and c(sp(3))-h bonds using monoprotected amino acids as chiral ligands  Academic Article
  • Pd(ii)-catalyzed olefination of electron-deficient arenes using 2,6-dialkylpyridine ligands  Academic Article
  • Peptide ligands for a sugar-binding protein isolated from a random peptide library  Academic Article
  • Peptidoglycan Metabolite Photoaffinity Reporters Reveal Direct Binding to Intracellular Pattern Recognition Receptors and Arf GTPases  Academic Article
  • Peptoid ligands that bind selectively to phosphoproteins  Academic Article
  • Perception of brassinosteroids by the extracellular domain of the receptor kinase BRI1  Academic Article
  • Performance-enhancing effects of crf-bp ligand inhibitors  Academic Article
  • Peroxisome proliferator-activated receptor (ppar) gamma coactivator-1 recruitment regulates ppar subtype specificity  Academic Article
  • Perspectives: drug delivery - Regulating export of ER cargo  Academic Article
  • Phage escape libraries for checkmate analysis  Academic Article
  • Pharmacology of nuclear receptor-coregulator recognition  Academic Article
  • Phenotypic and functional properties of human steady state CD14(+) and CD1a(+) antigen presenting cells and epidermal langerhans cells  Academic Article
  • Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners  Academic Article
  • Photo-induced oxidative cross-linking as a method to evaluate the specificity of protein-ligand interactions  Academic Article
  • Picrotoxinin receptor ligand blocks anti-punishment effects of alcohol  Academic Article
  • Piperidinyltetralin sigma ligands  Academic Article
  • Plant receptor kinases: systemin receptor identified  Academic Article
  • Plasma contains protein S monomers and multimers with similar direct anticoagulant activity  Academic Article
  • Polyspecificity of t cell and b cell receptor recognition  Academic Article
  • Polytriazoles as copper(I)-stabilizing ligands in catalysis  Academic Article
  • Porphyrin π-stacking in a heme protein scaffold tunes gas ligand affinity  Academic Article
  • Positive regulation of retinoic acid receptor alpha by protein kinase C and mitogen-activated protein kinase in sertoli cells  Academic Article
  • Post-SELEX combinatorial optimization of aptamers  Academic Article
  • Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies  Academic Article
  • Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro  Academic Article
  • Ppar gamma signaling exacerbates mammary gland tumor development  Academic Article
  • Predicting PDZ domain-peptide interactions from primary sequences  Academic Article
  • Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method  Academic Article
  • Preferential recognition of avian-like receptors in human influenza A H7N9 viruses  Academic Article
  • Preparation of stable maleimide-functionalized Au nanoparticles and their use in counting surface ligands  Academic Article
  • Printed covalent glycan array for ligand profiling of diverse glycan binding proteins  Academic Article
  • Printing proteins as microarrays for high-throughput function determination  Academic Article
  • Probing backbone hydrogen bonds in the hydrophobic core of GCN4  Academic Article
  • Probing domain interactions in soluble guanylate cyclase  Academic Article
  • Probing ligand recognition in the decarboxylase antibody 21d8: Implications for the catalytic mechanism  Academic Article
  • Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry  Academic Article
  • Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: Structures of the escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products  Academic Article
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  • Processing of integrin αv subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase  Academic Article
  • Production and detection of monoclonal anti-idiotype antibodies directed against a monoclonal anti-beta-adrenergic ligand antibody  Academic Article
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  • Protein assembly directed by synthetic molecular recognition motifs  Academic Article
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  • Protein microarrays: Prospects and problems  Academic Article
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  • Proton walk in the aqueous platinum complex tpptmeco via a sticky sigma-methane ligand  Academic Article
  • Proximity Tagging Identifies the Glycan-Mediated Glycoprotein Interactors of Galectin-1 in Muscle Stem Cells  Academic Article
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  • Qualitative and quantitative differences in t cell receptor binding of agonist and antagonist ligands  Academic Article
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  • Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP  Academic Article
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  • REV-ERB and ROR nuclear receptors as drug targets  Academic Article
  • Rapid identification of improved protein ligands using peptoid microarrays  Academic Article
  • Rapid identification of orexin receptor binding ligands using cell-based screening accelerated with magnetic beads  Academic Article
  • Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry  Academic Article
  • Rapid modulation of N-formyl chemotactic peptide receptors on the surface of human granulocytes: formation of high-affinity ligand-receptor complexes in transient association with cytoskeleton  Academic Article
  • Rational and modular design of potent ligands targeting the rna that causes myotonic dystrophy 2  Academic Article
  • Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions  Academic Article
  • Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: Application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3  Academic Article
  • Rational ligand design for the arylation of hindered primary amines guided by reaction progress kinetic analysis  Academic Article
  • Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue  Academic Article
  • Recent avian h5n1 viruses exhibit increased propensity for acquiring human receptor specificity  Academic Article
  • Recent developments and applications of clickable photoprobes in medicinal chemistry and chemical biology  Academic Article
  • Recent progress in the discovery of selective, non-peptide ligands of somatostatin receptors  Academic Article
  • Receptor differential activation and cooperativity better explain cellular preference for different chemoattractant gradient shapes in an EGFR system  Academic Article
  • Receptor for age (rage) mediates neointimal formation in response to arterial injury  Academic Article
  • Receptor for motilin identified in the human gastrointestinal system  Academic Article
  • Receptor rigidity and ligand mobility in trypsin-ligand complexes  Academic Article
  • Receptor-based assays  Academic Article
  • Receptor-templated stapling of intrinsically disordered peptide ligands  Academic Article
  • Recognition and catalysis in allylic alkylations  Academic Article
  • Recognition of microbial glycans by human intelectin-1  Academic Article
  • Recognition of physiological receptors by anti-idiotypic antibodies - molecular mimicry of the ligand or cross-reactivity  Academic Article
  • Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands  Academic Article
  • Recognition templates for predicting adenylate-binding sites in proteins  Academic Article
  • Recombinant expression of tlr5 proteins by ligand supplementation and a leucine-rich repeat hybrid technique  Academic Article
  • Recruitment of epidermal growth-factor and transferrin receptors into coated pits in-vitro - differing biochemical requirements  Academic Article
  • Reevaluating the substrate specificity of the L-type amino acid transporter (LAT1)  Academic Article
  • Refined crystallographic structure of pseudomonas aeruginosa exotoxin a and its implications for the molecular mechanism of toxicity  Academic Article
  • Regioselective base-free intermolecular aminohydroxylations of hindered and functionalized alkenes  Academic Article
  • Regulation of Pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor  Academic Article
  • Regulation of adipogenesis by natural and synthetic REV-ERB ligands  Academic Article
  • Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors  Academic Article
  • Regulation of feeding by galnon  Academic Article
  • Regulation of skin cell homeostasis by gamma delta T cells  Academic Article
  • Relationships between structure and activities of concanavalin a  Academic Article
  • Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure  Academic Article
  • Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 2. Effects on heme coordination and function  Academic Article
  • Resin-supported catalysts for CuAAC click reactions in aqueous or organic solvents  Academic Article
  • Resonance raman spectra of an o2-binding h-nox domain reveal heme relaxation upon mutation  Academic Article
  • Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network  Academic Article
  • Reversible photocontrol of biological systems by the incorporation of molecular photoswitches  Academic Article
  • Rhenium(vii) oxide catalyzed heteroacylative ring-opening dimerization of tetrahydrofuran  Academic Article
  • Rhodium-catalyzed and zinc(II)-triflate-promoted asymmetric hydrogenation of tetrasubstituted α,β-unsaturated ketones  Academic Article
  • Robust scoring functions for protein-ligand interactions with quantum chemical charge models  Academic Article
  • Role of N-acyl amino acid ligands in Pd(II)-catalyzed remote C-H activation of tethered arenes  Academic Article
  • Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase  Academic Article
  • Role of cell-surface lysines in plasminogen binding to cells: identification of alpha-enolase as a candidate plasminogen receptor  Academic Article
  • Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity - Different oligomers activate different signal transduction pathways  Academic Article
  • Role of electrostatic interactions in PDZ domain ligand recognition  Academic Article
  • Role of self-major histocompatibility complex/peptide ligands in selection and maintenance of a diverse t cell repertoire  Academic Article
  • S1p(1)-selective in vivo-active agonists from high-throughput screening: Off-the-shelf chemical probes of receptor interactions, signaling, and fate  Academic Article
  • SDOCKER: A method utilizing existing X-ray structures to improve docking accuracy  Academic Article
  • SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities  Academic Article
  • Scaffold composition and biological relevance of screening libraries  Academic Article
  • Scorpion-toxin mimics of cd4 in complex with human immunodeficiency virus gp120: Crystal structures, molecular mimicry, and neutralization breadth  Academic Article
  • Screening a peptidyl database for potential ligands to proteins with side-chain flexibility  Academic Article
  • Screening transthyretin amyloid fibril inhibitors: Characterization of novel multiprotein, multiligand complexes by mass spectrometry  Academic Article
  • Seamless bead to microarray screening: Rapid identification of the highest affinity protein ligands from large combinatorial libraries  Academic Article
  • Second-generation DBFOX ligands for the synthesis of β-substituted α-amino acids via enantioselective radical conjugate additions  Academic Article
  • Selection and application of peptide-binding peptides  Academic Article
  • Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms  Academic Article
  • Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells  Academic Article
  • Selection of phage-displayed peptides that bind to a particular ligand-bound antibody  Academic Article
  • Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening  Academic Article
  • Selective inhibition of oncogenic KRAS output with small molecules targeting the inactive state  Academic Article
  • Selective recognition and extraction of the uranyl ion  Academic Article
  • Selective recognition of oligomeric hiv-1 primary isolate envelope glycoprotelins by potently neutralizing ligands requires efficient precursor cleavage  Academic Article
  • Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy  Academic Article
  • Selective toxin sequestrants for the treatment of bacterial infections  Academic Article
  • Sensitizer-linked substrates and ligands: Ruthenium probes of cytochrome P450 structure and mechanism  Academic Article
  • Serotonin 5-ht(7) receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders  Academic Article
  • Sialoside analogue arrays for rapid identification of high affinity siglec ligands  Academic Article
  • Siglecs as sensors of self in innate and adaptive immune responses  Academic Article
  • Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells  Academic Article
  • Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer  Academic Article
  • Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma  Academic Article
  • Signal transduction and ligand-receptor dynamics in the human neutrophil. Transient responses and occupancy-response relations at the formyl peptide receptor  Academic Article
  • Silver(I)-promoted conversion of thioamides to amidines: divergent synthesis of a key series of vancomycin aglycon residue 4 amidines that clarify binding behavior to model ligands  Academic Article
  • Simicon: A web tool for protein-ligand model comparison through calculation of equivalent atomic contacts  Academic Article
  • Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands  Academic Article
  • Single-particle EM reveals plasticity of interactions between the adenovirus penton base and integrin alpha(V)beta(3)  Academic Article
  • Site identification by Ligand Competitive Saturation (SILCS) simulations for fragment-based drug design  Academic Article
  • Site-directed mutagenesis azotobacter-vinelandii ferredoxin-i - cysteine ligation of the 4fe-4s cluster with protein rearrangement is preferred over serine ligation  Academic Article
  • Site-directed mutagenesis of the human beta(3)-adrenoceptor - transmembrane residues involved in ligand binding and signal transduction  Academic Article
  • Site-selective C(sp3)-H functionalization of di-, tri-, and tetrapeptides at the N-terminus  Academic Article
  • Site-specific protein modification through Cu-I-catalyzed 1,2,3-triazole formation and its implementation in protein microarray fabrication  Academic Article
  • Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intron  Academic Article
  • Small molecule modulation of nuclear receptor conformational dynamics: implications for function and drug discovery  Academic Article
  • Small-molecule binding to an artificially created cavity at the active-site of cytochrome-c peroxidase  Academic Article
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  • Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids  Academic Article
  • Soluble mimetics of human immunodeficiency virus type 1 viral spikes produced by replacement of the native trimerization domain with a heterologous trimerization motif: Characterization and ligand binding analysis  Academic Article
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  • Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP  Academic Article
  • Solution-phase synthesis of combinatorial libraries designed to modulate protein-protein or protein-DNA interactions  Academic Article
  • Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control  Academic Article
  • Spectral and ligand-binding properties of an unusual hemoprotein, the ferric form of soluble guanylate cyclase  Academic Article
  • Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from vibrio cholerae and thermoanaerobacter tengcongensis  Academic Article
  • Sphingosine 1-phosphate pathway therapeutics: A lipid ligand-receptor paradigm  Academic Article
  • Sphingosine-1-phosphate and its receptors: Structure, signaling, and influence  Academic Article
  • Spin state and unfolding equilibria of ferricytochrome c in acidic solutions  Academic Article
  • Split tolerance in peripheral B cell subsets in mice expressing a low level of Ig kappa-reactive ligand  Academic Article
  • Stability of isoproterenol bound to cyanogen bromide-activated agarose  Academic Article
  • Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function  Academic Article
  • Structural analyses clarify the complex control of mistranslation by tRNA synthetases  Academic Article
  • Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1  Academic Article
  • Structural analysis of papain-like NlpC/p60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites  Academic Article
  • Structural and biochemical characterization of the therapeutic anabaena variabilis phenylalanine ammonia lyase  Academic Article
  • Structural and biophysical insights into the ligand-free Pitx2 homeodomain and a ring dermoid of the cornea inducing homeodomain mutant  Academic Article
  • Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica  Academic Article
  • Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors  Academic Article
  • Structural basis for a disfavored elimination reaction in catalytic antibody 1D4  Academic Article
  • Structural basis for allosteric regulation of GPCRs by sodium ions  Academic Article
  • Structural basis for high-affinity peptide inhibition of human Pin1  Academic Article
  • Structural basis for ligand recognition and discrimination of a quorum-quenching antibody  Academic Article
  • Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway  Academic Article
  • Structural basis for molecular recognition at serotonin receptors  Academic Article
  • Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen  Academic Article
  • Structural basis of single-nucleotide polymorphisms in cytochrome P450 2C9  Academic Article
  • Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism  Academic Article
  • Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica  Academic Article
  • Structural characterization of the Z ring-eIF4E complex reveals a distinct mode of control for eIF4E  Academic Article
  • Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the clostridium botulinum serotype a neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility  Academic Article
  • Structural evaluation of potent NKT cell agonists: Implications for design of novel stimulatory ligands  Academic Article
  • Structural features for functional selectivity at serotonin receptors  Academic Article
  • Structural implications for the design of molecular vaccines  Academic Article
  • Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor  Academic Article
  • Structural insights into neonatal Fc receptor-based recycling mechanisms  Academic Article
  • Structural interpretation of lanthanide binding to basic pancreatic trypsin-inhibitor by h-1 NMR at 360 mhz  Academic Article
  • Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus  Academic Article
  • Structural plasticity and the evolution of antibody affinity and specificity  Academic Article
  • Structural plasticity in the oestrogen receptor ligand-binding domain  Academic Article
  • Structural properties of non-traditional drug targets present new challenges for virtual screening  Academic Article
  • Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors  Academic Article
  • Structurally homologous ligand-binding of integrin mac-1 and viral glycoprotein-c receptors  Academic Article
  • Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor  Academic Article
  • Structure and function of von Willebrand factor  Academic Article
  • Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634  Academic Article
  • Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors  Academic Article
  • Structure and properties of a bis-histidyl ligated globin from caenorhabditis elegans  Academic Article
  • Structure based prediction of subtype-selectivity for adenosine receptor antagonists  Academic Article
  • Structure of REV-ERB beta ligand-binding domain bound to a porphyrin antagonist  Academic Article
  • Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator  Academic Article
  • Structure of a thioredoxin-like 2fe-2s ferredoxin from aquifex aeolicus  Academic Article
  • Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster  Academic Article
  • Structure of an MmyB-like regulator from C-aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes  Academic Article
  • Structure of an agonist-bound human A₂A adenosine receptor  Academic Article
  • Structure of nitric oxide synthase oxygenase dimer with pterin and substrate  Academic Article
  • Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex  Academic Article
  • Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone  Academic Article
  • Structure of the glucagon receptor in complex with a glucagon analogue  Academic Article
  • Structure of the human P2Y(12) receptor in complex with an antithrombotic drug  Academic Article
  • Structure of the human glucagon class B G-protein-coupled receptor  Academic Article
  • Structure of the human histamine h(1) receptor complex with doxepin  Academic Article
  • Structure of the human smoothened receptor bound to an antitumour agent  Academic Article
  • Structure of the intact ppar-gamma-rxr-alpha nuclear receptor complex on DNA  Academic Article
  • Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic  Academic Article
  • Structure-activity relationships in the binding of chemically derivatized cd4 to gp120 from human immunodeficiency virus  Academic Article
  • Structure-activity relationships through sequencing (stARTS) defines optimal and suboptimal RNA motif targets for small molecules  Academic Article
  • Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors  Academic Article
  • Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists  Academic Article
  • Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors  Academic Article
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  • Structure-based virtual screening and biological evaluation of Mycobacterium tuberculosis adenosine 5'-phosphosulfate reductase inhibitors  Academic Article
  • Structure-function of the G protein-coupled receptor superfamily  Academic Article
  • Structure-function-folding relationship in a WW domain  Academic Article
  • Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains  Academic Article
  • Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists  Academic Article
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  • Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations  Academic Article
  • Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: Heme activation via reduction-gated exogenous ligand exchange  Academic Article
  • Studies on reconstitution of bovine erythrocyte superoxide dismutase .4. Preparation and some properties of enzyme in which co(ii) is substituted for zn(ii)  Academic Article
  • Studies on the mechanism of oxidative-phosphorylation - effects of specific f-0 modifiers on ligand-induced conformation changes of f1  Academic Article
  • Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption  Academic Article
  • Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal  Academic Article
  • Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase  Academic Article
  • Substrate-ligand interactions in Geobacillus stearothermophilus nitric oxide synthase  Academic Article
  • Successful strategies to determine high-resolution structures of GPCRs  Academic Article
  • Sulfated ligands for the copper(I)-catalyzed azide-alkyne cycloaddition  Academic Article
  • Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand  Academic Article
  • Supramolecular complexing of membane siglec cd22 mediated by a polyvalent heterobifunctional ligand that templates on igm  Academic Article
  • Sweet spots in functional glycomics  Academic Article
  • Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands  Academic Article
  • Synthesis and activity of ruthenium alkylidene complexes coordinated with phosphine and N-heterocyclic carbene ligands  Academic Article
  • Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies  Academic Article
  • Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors  Academic Article
  • Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2  Academic Article
  • Synthesis and characterization of cerium and yttrium alkoxide complexes supported by ferrocene-based chelating ligands  Academic Article
  • Synthesis and evaluation of novel pyridine based PLG tripeptidomimetics  Academic Article
  • Synthesis and evaluation of vancomycin aglycon analogues that bear modifications in the N-terminal D-leucyl amino acid  Academic Article
  • Synthesis and screening of stereochemically diverse combinatorial libraries of peptide tertiary amides  Academic Article
  • Synthesis of Cyclic Anhydrides via Ligand-Enabled C-H Carbonylation of Simple Aliphatic Acids  Academic Article
  • Synthesis of a three zinc finger protein, Zif268, by native chemical ligation  Academic Article
  • Synthesizing and modifying peptides for chemoselective ligation and assembly into quantum dot-peptide bioconjugates  Academic Article
  • Synthetic carbohydrate dendrimers, part 11. Chemically defined sialoside scaffolds for investigation of multivalent interactions with sialic acid binding proteins  Academic Article
  • Synthetic enzyme inhibitor: A novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity  Academic Article
  • Synthetic receptors with antibody-like binding affinities  Academic Article
  • Synthetic small molecules that control stem cell fate  Academic Article
  • Systematic evaluation of bioorthogonal reactions in live cells with clickable Halo Tag ligands: implications for intracellular imaging  Academic Article
  • T-cell-receptor affinity and thymocyte positive selection  Academic Article
  • T0901317 is a dual lxr/fxr agonist  Academic Article
  • TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines  Academic Article
  • TOX3 is expressed in mammary ER(+) epithelial cells and regulates ER target genes in luminal breast cancer  Academic Article
  • Tagged versus untagged libraries - methods for the generation and screening of combinatorial chemical libraries  Academic Article
  • Tailored ligand acceleration of the Cu-catalyzed azide-alkyne cycloaddition reaction: practical and mechanistic implications  Academic Article
  • Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation  Academic Article
  • Targeting b lymphoma with nanoparticles bearing glycan ligands of cd22  Academic Article
  • Targeting heat shock proteins on cancer cells: Selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand  Academic Article
  • Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening  Academic Article
  • Tcr affinity and negative regulation limit autoimmunity  Academic Article
  • The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist  Academic Article
  • The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands  Academic Article
  • The Drosophila G protein-coupled receptor, Methuselah, exhibits a promiscuous response to peptides  Academic Article
  • The E-2.65 A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors  Academic Article
  • The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells  Academic Article
  • The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha  Academic Article
  • The RCSB protein data bank: New resources for research and education  Academic Article
  • The RCSB protein data bank: Redesigned web site and web services  Academic Article
  • The REV-ERBs and RORs: Molecular links between circadian rhythms and lipid homeostasis  Academic Article
  • The brain galanin receptors: targets for novel antidepressant drugs  Academic Article
  • The coactivator lxxll nuclear receptor recognition motif  Academic Article
  • The contactin-related protein FAR-2 defines Purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum  Academic Article
  • The crystal structure of avian cd1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian cd1  Academic Article
  • The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism  Academic Article
  • The discovery of 3-(n-alkyl)aminopropylphosphonic acids as potent s1p receptor agonists  Academic Article
  • The dynamic energy landscape of dihydrofolate reductase catalysis  Academic Article
  • The dynamics of ligand-receptor interactions. Real-time analyses of association, dissociation, and internalization of an N-formyl peptide and its receptors on the human neutrophil  Academic Article
  • The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor  Academic Article
  • The genesis of high-throughput structure-based drug discovery using protein crystallography  Academic Article
  • The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand  Academic Article
  • The importance of hydrophobic interactions in the antagonist binding to the muscarinic acetylcholine receptor  Academic Article
  • The importance of ligand-receptor conformational pairs in stabilization: spotlight on the N/OFQ G protein-coupled receptor  Academic Article
  • The importance of ligands for G protein-coupled receptor stability  Academic Article
  • The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin  Academic Article
  • The interleukin-1 system: Receptors, ligands, and ICE in the brain and their involvement in the fever response  Academic Article
  • The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gamma delta T cell activation  Academic Article
  • The leptin receptor system of human platelets  Academic Article
  • The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry  Academic Article
  • The mechanism of molecular redundancy in autoimmune inflammation in the context of CD44 deficiency  Academic Article
  • The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins  Academic Article
  • The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K  Academic Article
  • The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor  Academic Article
  • The nerve growth factor/tumor necrosis factor receptor family  Academic Article
  • The nuclear receptor lxr is a glucose sensor  Academic Article
  • The pharmacology of lxr  Academic Article
  • The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster  Academic Article
  • The privileged chemical space predictor (PCSP): A computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries  Academic Article
  • The quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution  Academic Article
  • The role of chelating diamine ligands in the goldberg reaction: a kinetic study on the copper-catalyzed amidation of aryl iodides  Academic Article
  • The role of dynamic conformational ensembles in biomolecular recognition  Academic Article
  • The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies  Academic Article
  • The role of platelet adhesion receptor GPIb alpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis  Academic Article
  • The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo  Academic Article
  • The specificity of tcr/pmhc interaction  Academic Article
  • The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae  Academic Article
  • The structure, organization, activation and plasticity of the erythropoietin receptor  Academic Article
  • The synthesis and in vivo evaluation of F-18 PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)  Academic Article
  • The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs  Academic Article
  • The tryptophan-derived ndogenous aryl hydrocarbon receptor ligand 6-formylindolo 3,2-b carbazole Is a nanomolar UVA photosensitizer in epidermal keratinocytes  Academic Article
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  • The use of carbohydrate microarrays to study carbohydrate-cell interactions and to detect pathogens  Academic Article
  • Themis sets the signal threshold for positive and negative selection in T-cell development  Academic Article
  • Therapeutics targeting the innate immune system  Academic Article
  • Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules  Academic Article
  • Thiophene-core estrogen receptor ligands having superagonist activity  Academic Article
  • Three-dimensional EM structure of the ectodomain of integrin alpha V beta 3 in a complex with fibronectin  Academic Article
  • Three-dimensional structure of the ephb2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition  Academic Article
  • Thymic selection by a single mhc/peptide ligand produces a semidiverse repertoire of cd4(+) t cells  Academic Article
  • Thymic selection by a single mhc/peptide ligand: Autoreactive t cells are low-affinity cells  Academic Article
  • Thymic selection threshold defined by compartmentalization of ras/mapk signalling  Academic Article
  • Thymocyte expression of cathepsin L is essential for NKT cell development  Academic Article
  • Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands  Academic Article
  • Tight association of the human mel(1a)-melatonin receptor and g(i): Precoupling and constitutive activity  Academic Article
  • Tissue factor signaling  Academic Article
  • Tissue- and epitope-specific mechanisms account for the diverse effects of anti-CD44 antibodies on the maintenance of primitive hematopoietic progenitors in vitro  Academic Article
  • Tlr4/md-2 monoclonal antibody therapy affords protection in experimental models of septic shock  Academic Article
  • Toll-like receptor signaling inhibits hepatitis B virus replication in vivo  Academic Article
  • Toll-like receptors in atherosclerosis  Academic Article
  • Topographical distribution of redox centers and the q(o) site in ubiquinol-cytochrome-c oxidoreductase (complex-iii) and ligand structure of the rieske iron-sulfur cluster  Academic Article
  • Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta(3) subunit  Academic Article
  • Toward a rational design of peptide inhibitors of ribonucleotide reductase: structure-function and modeling studies  Academic Article
  • Transduction of dendritic cells with Bcl-xL increases their resistance to prostate cancer-induced apoptosis and antitumor effect in mice  Academic Article
  • Transformation of low-affinity lead compounds into high-affinity protein capture agents  Academic Article
  • Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation  Academic Article
  • Treatment with lxr agonists after focal cerebral ischemia prevents brain damage  Academic Article
  • Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor  Academic Article
  • Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures  Academic Article
  • Tryptophan-accelerated electron flow through proteins  Academic Article
  • Tumor regression by targeted gene delivery to the neovasculature  Academic Article
  • Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (h-nox) domain  Academic Article
  • Turning G proteins on and off using peptide ligands  Academic Article
  • Two antigenically related neuronal cell adhesion molecules of different specificities mediate neuron-neuron and neuron-glia adhesion  Academic Article
  • Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency  Academic Article
  • Two independent sets of monoclonal antibodies define neoepitopes linked to soluble ligand binding and leukocyte adhesion functions of activated alpha(M)beta(2)  Academic Article
  • Two ligands may bind simultaneously to the muscarine receptor  Academic Article
  • Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa  Academic Article
  • Two-dimensional IR spectroscopy of protein dynamics using two vibrational labels: a site-specific genetically encoded unnatural amino acid and an active site ligand  Academic Article
  • Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactions  Academic Article
  • Two-dimensional combinatorial screening identifies specific 6 '-acylated kanamycin A- and 6 '-acylated neamine-RNA hairpin interactions  Academic Article
  • Two-dimensional combinatorial screening identifies specific aminoglycoside - RNA internal loop partners  Academic Article
  • UV and sunlight driven photoligation of quantum dots: understanding the photochemical transformation of the ligands  Academic Article
  • Underscoring the influence of inorganic chemistry on nuclear imaging with radiometals  Academic Article
  • Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase  Academic Article
  • Unique ability of integrin alpha(v)beta(3) to support tumor cell arrest under dynamic flow conditions  Academic Article
  • Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange  Academic Article
  • Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops  Academic Article
  • Unlocking nature's C-H bonds  Academic Article
  • Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease iv  Academic Article
  • Unusual arginine formations in protein function and assembly: Rings, strings, and stacks  Academic Article
  • Uranyl ion coordination with rigid aromatic carboxylates and structural characterization of their complexes  Academic Article
  • Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior  Academic Article
  • Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling  Academic Article
  • Use of phage display and transition-state analogs to select enzyme variants with altered catalytic properties: Glutathione transferase as an example  Academic Article
  • Using AutoDock for ligand-receptor docking  Academic Article
  • Using modularly assembled ligands to bind RNA internal loops separated by different distances  Academic Article
  • Utility of redundant combinatorial libraries in distinguishing high and low quality screening hits  Academic Article
  • Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention  Academic Article
  • Vanadium-catalyzed asymmetric epoxidation of allylic alcohols in water  Academic Article
  • Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue, and West Nile viruses  Academic Article
  • Virtual screening for HIV protease inhibitors: a comparison of AutoDock 4 and Vina  Academic Article
  • Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors  Academic Article
  • Virtual screening of integrase inhibitors by large scale binding free energy calculations: the SAMPL4 challenge  Academic Article
  • Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challenge  Academic Article
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  • When does chemical elaboration induce a ligand to change its binding mode?  Academic Article
  • X-ray structures of the LXRα LBD in its homodimeric form and implications for heterodimer signaling  Academic Article
  • cDNA sequence, ligand biding, and regulation of galanin/GMAP in mouse brain  Academic Article
  • p Enhancement of Gene Knockdown on CD22-Expressing Cells by Chemically Modified Glycan Ligand-siRNA Conjugates  Academic Article
  • αβ T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization  Academic Article

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