subject area of

• 13C NMR studies of the product complex of glyoxalase I  Academic Article
• 2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations  Academic Article
• 3D C(CC)H TOCSY experiment for assigning protons and carbons in uniformly 13C- and selectively 2H-labeled RNA  Academic Article
• A DNA-based cancer vaccine enhances lymphocyte cross talk by engaging the nkg2d receptor  Academic Article
• A LecA ligand identified from a galactoside-conjugate array inhibits host cell invasion by Pseudomonas aeruginosa  Academic Article
• A bifunctional molecule that displays context-dependent cellular activity  Academic Article
• A biomimetic polyketide-inspired approach to small-molecule ligand discovery  Academic Article
• A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy  Academic Article
• A chemical approach for detecting sulfenic acid-modified proteins in living cells  Academic Article
• A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (ppar alpha) versus liver x receptor  Academic Article
• A chemically induced vaccine strategy for prostate cancer  Academic Article
• A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPAR gamma partial agonists  Academic Article
• A cross-strand Trp-Trp pair stabilizes the hPin1 WW domain at the expense of function  Academic Article
• A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome  Academic Article
• A designed peptidomimetic agonistic ligand of trka nerve growth factor receptors  Academic Article
• A dominant-negative peroxisome proliferator-activated receptor gamma (ppar gamma) mutant is a constitutive repressor and inhibits ppar gamma-mediated adipogenesis  Academic Article
• A five-amino-acid motif in the undefined region of the tlr8 ectodomain is required for species-specific ligand recognition  Academic Article
• A fluorinated ligand enables room-temperature and regioselective Pd-catalyzed fluorination of aryl triflates and bromides  Academic Article
• A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking  Academic Article
• A functional hot spot for antigen recognition in a superagonist TCR/MHC complex  Academic Article
• A global benchmark study using affinity-based biosensors  Academic Article
• A high-throughput ligand competition binding assay for the androgen receptor and other nuclear receptors  Academic Article
• A labeled guanidine ligand for studying sweet taste  Academic Article
• A liquid array platform for the multiplexed analysis of synthetic molecule-protein interactions  Academic Article
• A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes - crystal structure of human leukocyte antigen (hla)-a1-mage-a1 in complex with fab-hyb3  Academic Article
• A maltose-binding protein fusion construct yields a robust crystallography platform for MCL1  Academic Article
• A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands  Academic Article
• A metallopeptide assembly of the HIV-1 gp41 coiled coil is an ideal receptor in fluorescence detection of ligand binding  Academic Article
• A molecular basis for no selectivity in soluble guanylate cyclase  Academic Article
• A molecular model of RGD ligands. Antibody D gene segments that direct specificity for the integrin alpha IIb beta 3  Academic Article
• A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity  Academic Article
• A natural product ligand of the oxysterol receptor, liver x receptor  Academic Article
• A near-IR uncaging strategy based on cyanine photochemistry  Academic Article
• A new approach to osmium-catalyzed asymmetric dihydroxylation and aminohydroxylation of olefins  Academic Article
• A new mechanism of allostery in a G protein-coupled receptor dimer  Academic Article
• A new spatial structure for the axial methionine observed in cytochrome c5 from pseudomonas-mendocina - correlations with the electronic-structure of heme-c  Academic Article
• A novel method for analyzing extremely biased agonism at G protein-coupled receptors  Academic Article
• A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests  Academic Article
• A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects  Academic Article
• A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity  Academic Article
• A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site  Academic Article
• A phosphoarginine containing peptide as an artificial SH2 ligand  Academic Article
• A plant-like kinase in plasmodium falciparum regulates parasite egress from erythrocytes  Academic Article
• A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding  Academic Article
• A population of murine gamma delta T cells that recognize an inducible MHC class Ib molecule  Academic Article
• A proximity based general method for identification of ligand and receptor interactions in living cells  Academic Article
• A review of the human sigma-1 receptor structure  Academic Article
• A rigid trans-spanning dinitrile ligand  Academic Article
• A role for rev-erb alpha ligands in the regulation of adipogenesis  Academic Article
• A role for tcr affinity in regulating naive t cell homeostasis  Academic Article
• A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280  Academic Article
• A second endogenous cannabinoid that modulates long-term potentiation  Academic Article
• A second-generation copper(II)-mediated metallo-DNA-base pair  Academic Article
• A semiempirical free energy force field with charge-based desolvation  Academic Article
• A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors  Academic Article
• A slippery grip  Academic Article
• A small molecule microarray platform to select RNA internal loop-ligand interactions  Academic Article
• A sphingosine 1-phosphate receptor 2 selective allosteric agonist  Academic Article
• A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA  Academic Article
• A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states  Academic Article
• A structure-activity study of nociceptin-(1-13)-peptide amide. Synthesis of analogues substituted in positions 0, 1, 3, 4 and 10  Academic Article
• A tetradentate ligand for the enantioselective Ti(IV)-promoted oxidation of sulfides to sulfoxides: origin of enantioselectivity  Academic Article
• A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes  Academic Article
• ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase  Academic Article
• Ablation of cd22 in ligand-deficient mice restores b cell receptor signaling  Academic Article
• Accelerated bioorthogonal conjugation: A practical method for the ligation of diverse functional molecules to a polyvalent virus scaffold  Academic Article
• Acceleration of nucleophilic ch activation by strongly basic solvents  Academic Article
• Action of RORs and their ligands in (patho)physiology  Academic Article
• Activation of PPARdelta alters lipid metabolism in db/db mice  Academic Article
• Activation of protein kinase c by phorbol dibutyrate modulates gaba(a) receptor binding in rat brain slices  Academic Article
• Activation of the liver x receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy  Academic Article
• Activators of the nuclear receptor ppar gamma enhance colon polyp formation  Academic Article
• Adenosine: a partial agonist of the growth hormone secretagogue receptor  Academic Article
• Adenovirus fiber shaft contains a trimerization element that supports peptide fusion for targeted gene delivery  Academic Article
• Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling  Academic Article
• Administration of recombinant p-selectin glycoprotein ligand fc fusion protein suppresses inflammation and neointimal formation in zucker diabetic rat model  Academic Article
• Affinity-based ranking of ligands for DPP-4 from mixtures  Academic Article
• Agonist-bound structure of the human P2Y(12) receptor  Academic Article
• Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence  Academic Article
• Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors  Academic Article
• Allosteric inhibition of hypoxia inducible factor-2 with small molecules  Academic Article
• Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists  Academic Article
• Altered functional and biochemical response by CD8+ T cells that remain after tolerance  Academic Article
• Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality  Academic Article
• Aluminum-catalyzed asymmetric addition of TMSCN to aromatic and aliphatic ketones promoted by an easily accessible and recyclable peptide ligand  Academic Article
• Amino-acid-sequence, hem-iron coordination geometry and functional-properties of mitochondrial and bacterial c-type cytochromes  Academic Article
• Amyloid beta-peptide polymerization studied using fluorescence correlation spectroscopy  Academic Article
• An "orphan" finds a home in NSC regulation  Academic Article
• An NMR perspective on enzyme dynamics  Academic Article
• An alkoxide-directed intermolecular 2+2+1 annulation: A three-component coupling reaction for the synthesis of tetrasubstituted alpha,beta,-unsaturated gamma-lactams  Academic Article
• An alternate binding site for PPARγ ligands  Academic Article
• An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket  Academic Article
• An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation  Academic Article
• An intense form of homeostatic proliferation of naive cd8(+) cells driven by il-2  Academic Article
• An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification  Academic Article
• Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries  Academic Article
• Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes  Academic Article
• Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies  Academic Article
• Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes  Academic Article
• Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity  Academic Article
• Antagonists of the kappa opioid receptor  Academic Article
• Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR gamma by Cdk5  Academic Article
• Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides  Academic Article
• Antibody domain exchange is an immunological solution to carbohydrate cluster recognition  Academic Article
• Antibody remodeling - a general-solution to the design of a metal-coordination site in an antibody-binding pocket  Academic Article
• Anticonvulsant activity of a nonpeptide galanin receptor agonist  Academic Article
• Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation  Academic Article
• Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis  Academic Article
• Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry  Academic Article
• Application of affinity selection/mass spectrometry to determine the structural isomer of parnafungins responsible for binding polyadenosine polymerase  Academic Article
• Applications of laser-polarized (129)Xe to biomolecular assays  Academic Article
• Approaches toward selective inhibition of nitric oxide synthase  Academic Article
• Aptasensors for biosecurity applications  Academic Article
• Area specificity and topography of thalamocortical projections are controlled by ephrin/eph genes  Academic Article
• Arrest of beta-amyloid fibril formation by a pentapeptide ligand  Academic Article
• Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor  Academic Article
• Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein  Academic Article
• Aspartate-transcarbamylase lacking catalytic subunit interactions - study of conformational-changes by uv absorbance and circular-dichroism spectroscopy  Academic Article
• Assembly of PNA-tagged small molecules, peptides, and carbohydrates onto DNA templates: programming the combinatorial pairing and inter-ligand distance  Academic Article
• Association of neuronal calcium channels with modular adaptor proteins  Academic Article
• Asymmetric total syntheses of aspidodasycarpine, lonicerine, and the proposed structure of lanciferine  Academic Article
• Atherosclerosis induced by endogenous and exogenous toll-like receptor (tlr)1 or tlr6 agonists  Academic Article
• AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading  Academic Article
• AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility  Academic Article
• AutoDock4(Zn): an improved AutoDock force field for small-molecule docking to zinc metalloproteins  Academic Article
• AutoDockFR: Advances in protein-ligand docking with explicitly specified binding site flexibility  Academic Article
• Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA  Academic Article
• Autologous regulation of naive t cell homeostasis within the t cell compartment  Academic Article
• Automated docking of flexible ligands: applications of AutoDock  Academic Article
• Automated docking of ligands to an artificial active site: augmenting crystallographic analysis with computer modeling  Academic Article
• Automated docking to multiple target structures: incorporation of protein mobility and structural water heterogeneity in AutoDock  Academic Article
• Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase  Academic Article
• Automated hydrogen/deuterium exchange electron transfer dissociation high resolution mass spectrometry measured at single-amide resolution  Academic Article
• Automated prediction of ligand-binding sites in proteins  Academic Article
• Avidity of cd1d-ligand-receptor ternary complex contributes to t-helper 1 (th1) polarization and anticancer efficacy  Academic Article
• Aza-amino acid scanning of chromobox homolog 7 (CBX7) ligands  Academic Article
• Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential  Academic Article
• B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen  Academic Article
• B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention  Academic Article
• BRI1 is a critical component of a plasma-membrane receptor for plant steroids  Academic Article
• Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery  Academic Article
• Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation  Academic Article
• Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off rags and promotes B cell-positive selection  Academic Article
• Benzimidazole and related ligands for Cu-catalyzed azide-alkyne cycloaddition  Academic Article
• Biased signaling pathways in betaβ2-adrenergic receptor characterized by 19F-NMR  Academic Article
• Bicyclic core estrogens as full antagonists: Synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides  Academic Article
• Bifunctional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells  Academic Article
• Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells  Academic Article
• Binding and functional properties of concanavalin-a and its derivatives .3. Interactions with indoleacetic-acid and other hydrophobic ligands  Academic Article
• Binding of alpha(2)-macroglobulin and limulin: Regulation of the plasma haemolytic system of the american horseshoe crab, limulus  Academic Article
• Binding of proteins to cnbr-activated sepharose 4b  Academic Article
• Biochemical and structural analysis of nuclear protein import  Academic Article
• Biochemistry of soluble guanylate cyclase  Academic Article
• Biocompatible click chemistry enabled compartment-specific pH measurement inside E-coli  Academic Article
• Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors  Academic Article
• Blocking transcription through a nucleosome with synthetic DNA ligands  Academic Article
• BluB cannibalizes flavin to form the lower ligand of vitamin B-12  Academic Article
• Blue-fluorescent antibodies  Academic Article
• Bmp signaling is required for development of primary lens fiber cells  Academic Article
• Building synthetic antibodies as adhesive ligands for integrins  Academic Article
• Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase  Academic Article
• C5L2, a nonsignaling C5A binding protein  Academic Article
• CCL3L1 and HIV/AIDS susceptibility  Academic Article
• CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia  Academic Article
• CD44 receptor unfolding enhances binding by freeing basic amino acids to contact carbohydrate ligand  Academic Article
• CD8αα and ‐αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I  Academic Article
• CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase  Academic Article
• CSI-FID: high throughput label-free detection of DNA binding molecules  Academic Article
• Carbon-deuterium bonds as probes of dihydrofolate reductase  Academic Article
• Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis  Academic Article
• Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: Crystal structures of abzyme 21D8  Academic Article
• Catalytic and regioselective ring expansion of arylcyclobutanones with trimethylsilyldiazomethane. Ligand-dependent entry to beta-ketosilane or enolsilane adducts  Academic Article
• Catalyzed oxidative corrosion of porous silicon used as an optical transducer for ligand-receptor interactions  Academic Article
• Cbp/p300 taz1 domain forms a structured scaffold for ligand binding  Academic Article
• Cd22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of b cells  Academic Article
• Cd62 and endothelial-cell leukocyte adhesion molecule-1 (elam-1) recognize the same carbohydrate ligand, sialyl-lewis-x  Academic Article
• Cell surface biology mediated by low affinity multivalent protein-glycan interactions  Academic Article
• Cell, isoform, and environment factors shape gradients and modulate chemotaxis  Academic Article
• Changes in structure and dynamics of the fv fragment of a catalytic antibody upon binding of inhibitor  Academic Article
• Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry  Academic Article
• Characterization of pharmacologically active antipeptide antibodies directed against the first and 2nd extracellular loops of the serotonin 5-ht1a receptor  Academic Article
• Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands  Academic Article
• Characterization of the structure and function of W -> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding  Academic Article
• Charting a path to success in virtual screening  Academic Article
• Chemical approaches to nuclear receptors in metabolism  Academic Article
• Chemical approaches to the lysophospholipid receptors  Academic Article
• Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts  Academic Article
• Chemical fragments as foundations for understanding target space and activity prediction  Academic Article
• Chemical microarrays to identify ligands that bind pathogenic cells  Academic Article
• Chemical probes of endocannabinoid metabolism  Academic Article
• Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer  Academic Article
• Chemically regulated zinc finger transcription factors  Academic Article
• Chemistry and molecular biology of galanin receptor ligands  Academic Article
• Chemoenzymatic synthesis of sialyl-trimeric-Lewis X  Academic Article
• Chemoproteomic screening of covalent ligands reveals UBA5 as a novel pancreatic cancer target  Academic Article
• Chemotype-selective modes of action of κ-opioid receptor agonists  Academic Article
• Chronic nicotine treatment counteracts dopamine d-2 receptor up-regulation induced by a partial meso-diencephalic hemitransection in the rat  Academic Article
• Classification of PDZ domains  Academic Article
• Cloning, expression, and characterization of a nitric oxide synthase protein from deinococcus radiodurans  Academic Article
• Closely related antibody receptors exploit fundamentally different strategies for steroid recognition  Academic Article
• Coexpression of beta-1-adrenergic and beta-2-adrenergic receptors on bovine brain capillary endothelial-cells in culture  Academic Article
• Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis  Academic Article
• Combinatorial chemistry: A liquid-phase approach  Academic Article
• Commensal bacteria make GPCR ligands that mimic human signalling molecules  Academic Article
• Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008  Academic Article
• Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus  Academic Article
• Comparison of intra- vs intermolecular long-range electron transfer in crystals of ruthenium-modified azurin  Academic Article
• Computational fragment-based binding site identification by ligand competitive saturation  Academic Article
• Computational functional group mapping for drug discovery  Academic Article
• Computational protein-ligand docking and virtual drug screening with the AutoDock suite  Academic Article
• Conformational changes in aspartate transcarbamylase. II. Circular dichroism evidence for the involvement of metal ions in allosteric interactions  Academic Article
• Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding  Academic Article
• Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions  Academic Article
• Conformational effects in biological catalysis: an antibody-catalyzed oxy-Cope rearrangement  Academic Article
• Conformational flexibility in the flap domains of ligand-free HIV protease  Academic Article
• Conformational flexibility of b-DNA at 0.74 Å resolution: D(ccagtactgg)(2)  Academic Article
• Conformational isomerism can limit antibody catalysis  Academic Article
• Conformational states of the full-length glucagon receptor  Academic Article
• Conserved binding mode of human beta(2) adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography  Academic Article
• Conserved glycine 232 in the ligand channel of ba(3) cytochrome oxidase from Thermus thermophilus  Academic Article
• Constitutive activity of the melanocortin-4 receptor is maintained by its n-terminal domain and plays a role in energy homeostasis in humans  Academic Article
• Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c  Academic Article
• Contemporary paradigms for cholinergic ligand design guided by biological structure  Academic Article
• Controlling the architecture, coordination, and reactivity of nanoparticle coating utilizing an amino acid central scaffold  Academic Article
• Cooperative binding of magnesium to transfer ribonucleic acid studied by a fluorescent probe  Academic Article
• Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22  Academic Article
• Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies  Academic Article
• Cortistatin a is a high-affinity ligand of protein kinases rock, cdk8, and cdk11  Academic Article
• Coumarin derivatives as substrate probes of mammalian cytochromes P450 2B4 and 2B6: assessing the importance of 7-Alkoxy chain length, halogen substitution, and non-active site mutations  Academic Article
• Coupling of receptor conformation and ligand orientation determine graded activity  Academic Article
• Covalent and 3-dimensional structure of concanavalin-a .3. Structure of monomer and its interactions with metals and saccharides  Academic Article
• Covalent docking using autodock: two-point attractor and flexible side chain methods  Academic Article
• Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products  Academic Article
• Covalently-linked ligand stabilizes expression of heterodimeric receptor  Academic Article
• Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling  Academic Article
• Cryopreservation of postnatal rat retinal ganglion cells: persistence of voltage- and ligand-gated ionic currents  Academic Article
• Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution  Academic Article
• Crystal structure of S-adenosylmethionine : tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold  Academic Article
• Crystal structure of a gamma delta t cell receptor ligand t22: A truncated mhc-like fold  Academic Article
• Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution  Academic Article
• Crystal structure of adenosine 5 '-phosphosulfate kinase from Penicillium chrysogenum  Academic Article
• Crystal structure of antagonist bound human lysophosphatidic acid receptor 1  Academic Article
• Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening  Academic Article
• Crystal structure of human cytochrome p450 2d6 with prinomastat bound  Academic Article
• Crystal structure of human toll-like receptor 3 (tlr3) ectodomain  Academic Article
• Crystal structure of mouse cd1: An mhc-like fold with a large hydrophobic binding groove  Academic Article
• Crystal structure of mouse cd1d bound to the self ligand phosphatidylcholine: A molecular basis for nkt cell activation  Academic Article
• Crystal structure of soluble md-1 and its interaction with lipid iva  Academic Article
• Crystal structure of the TCR co-receptor CD8 alpha alpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution  Academic Article
• Crystal structure of the human 4-1BB/4-1BBL complex  Academic Article
• Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of camp-dependent protein kinase  Academic Article
• Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892  Academic Article
• Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor  Academic Article
• Crystal structures of apolipoprotein(a) kringle iv37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: Existence of novel and expected binding modes  Academic Article
• Crystal structures of cytochrome p450 2b4 in complex with the inhibitor 1-biphenyl-4-methyl-1h-imidazole: Ligand-induced structural response through alpha-helical repositioning  Academic Article
• Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands  Academic Article
• Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain  Academic Article
• Crystallization of murine major histocompatibility complex class-i h-2kb with single peptides  Academic Article
• Curariform antagonists bind in different orientations to acetylcholine-binding protein  Academic Article
• Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins  Academic Article
• Cutting edge: Trimolecular interaction of tcr with mhc class ii and bacterial superantigen shows a similar affinity to mhc : Peptide ligands  Academic Article
• Cutting edge: dendritic epidermal gamma delta T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding  Academic Article
• Cyclic and linear oligocarbamate ligands for human thrombin  Academic Article
• Cyclin-dependent kinases 5 template: useful for virtual screening  Academic Article
• Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site  Academic Article
• Cytokine receptor dimerization and activation: prospects for small molecule agonists  Academic Article
• Cytotactin and its proteoglycan ligand mark structural and functional boundaries in somatosensory cortex of the early postnatal mouse  Academic Article
• Cytotoxicity of quantum dots used for in vitro cellular labeling: role of QD surface ligand, delivery modality, cell type, and direct comparison to organic fluorophores  Academic Article
• DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid  Academic Article
• DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex  Academic Article
• DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands  Academic Article
• DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia  Academic Article
• DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the nkg2d receptor  Academic Article
• Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo  Academic Article
• Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex  Academic Article
• Defective lymphotoxin-β receptor-induced NF-κB transcriptional activity in NIK-deficient mice  Academic Article
• Defining the communication between agonist and coactivator binding in the retinoid X receptor alpha ligand binding domain  Academic Article
• Defining the conditional basis of silicon phthalocyanine near-IR ligand exchange  Academic Article
• Defining the rna internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis  Academic Article
• Deletion mutants of human interleukin 1β with significantly reduced agonist properties: Search for the agonist/antagonist switch in ligands to the interleukin 1 receptors  Academic Article
• Delineation of the peptide binding site of the human galanin receptor  Academic Article
• Delta(9)-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta(9)-tetrahydrocannabinol  Academic Article
• Density functional calculation of pKa values and redox potentials in the bovine Rieske iron-sulfur protein  Academic Article
• Density functional study of a mu-1,1-carboxylate bridged Fe(III)-O-Fe(IV) model complex. 2. Comparison with ribonucleotide reductase intermediate X  Academic Article
• Derivation of a retinoid x receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1h-indol-3-yl)methyl-4-trifluoromethylbenzene  Academic Article
• Design and synthesis of a rapamycin-based high-affinity binding fkbp12 ligands  Academic Article
• Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching  Academic Article
• Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant  Academic Article
• Design of a selective chemical probe for class I PDZ domains  Academic Article
• Design of molecular logic devices based on a programmable DNA-regulated semisynthetic enzyme  Academic Article
• Design, synthesis and biological evaluation of nonpeptide integrin antagonists  Academic Article
• Designing small-molecule switches for protein-protein interactions  Academic Article
• Detailed analysis of grid-based molecular docking: a case study of CDOCKER - A CHARMm-based MD docking algorithm  Academic Article
• Detailed analysis of the free and bound conformations of an antibody - x-ray structures of fab 17/9 and 3 different fab-peptide complexes  Academic Article
• Detection of stealthy small amphiphilic biomarkers  Academic Article
• Determinants of cytochrome P4502C8 substrate binding - structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid  Academic Article
• Determinants of ligand affinity and heme reactivity in h-nox domains  Academic Article
• Determinants of the heme-CO vibrational modes in the H-NOX family  Academic Article
• Determination of fe-ligand bond lengths and the fe-n-o bond angles in soybean ferrous and ferric nitrosylleghemoglobin alpha using multiple-scattering xafs analyses  Academic Article
• Developing ligands for palladium(II)-catalyzed C-H functionalization: intimate dialogue between ligand and substrate  Academic Article
• Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor  Academic Article
• Development of Pseudomonas aeruginosa lectin LecA inhibitor by using bivalent galactosides supported on polyproline peptide scaffolds  Academic Article
• Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3)  Academic Article
• Development of an intact cell reporter gene beta-lactamase assay for g protein-coupled receptors for high-throughput screening  Academic Article
• Development of antibody surrogates for the treatment of cancers and autoimmune disease  Academic Article
• Development of functionally selective, small molecule agonists at kappa opioid receptors  Academic Article
• Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy  Academic Article
• Development of protein-detecting microarrays and related devices  Academic Article
• Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: Defining the binding mode of 7-oxabicyclo 2.2.1 hept-5-ene scaffold core ligands  Academic Article
• Dextran as a generally applicable multivalent scaffold for improving immunoglobulin-binding affinities of peptide and peptidomimetic ligands  Academic Article
• Diastereo- and enantioselective iridium-catalyzed allylation of cyclic ketone enolates: synergetic effect of ligands and barium enolates  Academic Article
• Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands  Academic Article
• Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively  Academic Article
• Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions  Academic Article
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• Peptide ligands for a sugar-binding protein isolated from a random peptide library  Academic Article
• Peptoid ligands that bind selectively to phosphoproteins  Academic Article
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• Peroxisome proliferator-activated receptor (ppar) gamma coactivator-1 recruitment regulates ppar subtype specificity  Academic Article
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• Polytriazoles as copper(I)-stabilizing ligands in catalysis  Academic Article
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• Receptor-based assays  Academic Article
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• Recognition of microbial glycans by human intelectin-1  Academic Article
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• Rhodium-catalyzed and zinc(II)-triflate-promoted asymmetric hydrogenation of tetrasubstituted α,β-unsaturated ketones  Academic Article
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• Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from vibrio cholerae and thermoanaerobacter tengcongensis  Academic Article
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• Sphingosine-1-phosphate and its receptors: Structure, signaling, and influence  Academic Article
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• Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function  Academic Article
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• Structural analysis of papain-like NlpC/p60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites  Academic Article
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• Structural basis for a disfavored elimination reaction in catalytic antibody 1D4  Academic Article
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• Structural basis for high-affinity peptide inhibition of human Pin1  Academic Article
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• Structural basis for molecular recognition at serotonin receptors  Academic Article
• Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen  Academic Article
• Structural basis of single-nucleotide polymorphisms in cytochrome P450 2C9  Academic Article
• Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism  Academic Article
• Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica  Academic Article
• Structural characterization of the Z ring-eIF4E complex reveals a distinct mode of control for eIF4E  Academic Article
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• Structural features for functional selectivity at serotonin receptors  Academic Article
• Structural implications for the design of molecular vaccines  Academic Article
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• Structural insights into neonatal Fc receptor-based recycling mechanisms  Academic Article
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• Structure of REV-ERB beta ligand-binding domain bound to a porphyrin antagonist  Academic Article
• Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator  Academic Article
• Structure of a thioredoxin-like 2fe-2s ferredoxin from aquifex aeolicus  Academic Article
• Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster  Academic Article
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• Structure of nitric oxide synthase oxygenase dimer with pterin and substrate  Academic Article
• Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex  Academic Article
• Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone  Academic Article
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• Structure of the human glucagon class B G-protein-coupled receptor  Academic Article
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• Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors  Academic Article
• Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists  Academic Article
• Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors  Academic Article
• Structure-based stabilization of hiv-1 gp120 enhances humoral immune responses to the induced co-receptor binding site  Academic Article
• Structure-based virtual screening and biological evaluation of Mycobacterium tuberculosis adenosine 5'-phosphosulfate reductase inhibitors  Academic Article
• Structure-function of the G protein-coupled receptor superfamily  Academic Article
• Structure-function-folding relationship in a WW domain  Academic Article
• Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains  Academic Article
• Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists  Academic Article
• Structure/function studies on a S-adenosyl-(L)-methionine-dependent uroporphyrinogen III C methyltransferase (SUMT), a key regulatory enzyme of tetrapyrrole biosynthesis  Academic Article
• Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations  Academic Article
• Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: Heme activation via reduction-gated exogenous ligand exchange  Academic Article
• Studies on reconstitution of bovine erythrocyte superoxide dismutase .4. Preparation and some properties of enzyme in which co(ii) is substituted for zn(ii)  Academic Article
• Studies on the mechanism of oxidative-phosphorylation - effects of specific f-0 modifiers on ligand-induced conformation changes of f1  Academic Article
• Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption  Academic Article
• Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal  Academic Article
• Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase  Academic Article
• Substrate-ligand interactions in Geobacillus stearothermophilus nitric oxide synthase  Academic Article
• Successful strategies to determine high-resolution structures of GPCRs  Academic Article
• Sulfated ligands for the copper(I)-catalyzed azide-alkyne cycloaddition  Academic Article
• Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand  Academic Article
• Supramolecular complexing of membane siglec cd22 mediated by a polyvalent heterobifunctional ligand that templates on igm  Academic Article
• Sweet spots in functional glycomics  Academic Article
• Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands  Academic Article
• Synthesis and activity of ruthenium alkylidene complexes coordinated with phosphine and N-heterocyclic carbene ligands  Academic Article
• Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies  Academic Article
• Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors  Academic Article
• Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2  Academic Article
• Synthesis and characterization of cerium and yttrium alkoxide complexes supported by ferrocene-based chelating ligands  Academic Article
• Synthesis and evaluation of novel pyridine based PLG tripeptidomimetics  Academic Article
• Synthesis and evaluation of vancomycin aglycon analogues that bear modifications in the N-terminal D-leucyl amino acid  Academic Article
• Synthesis and screening of stereochemically diverse combinatorial libraries of peptide tertiary amides  Academic Article
• Synthesis of a three zinc finger protein, Zif268, by native chemical ligation  Academic Article
• Synthesizing and modifying peptides for chemoselective ligation and assembly into quantum dot-peptide bioconjugates  Academic Article
• Synthetic carbohydrate dendrimers, part 11. Chemically defined sialoside scaffolds for investigation of multivalent interactions with sialic acid binding proteins  Academic Article
• Synthetic enzyme inhibitor: A novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity  Academic Article
• Synthetic receptors with antibody-like binding affinities  Academic Article
• Synthetic small molecules that control stem cell fate  Academic Article
• Systematic evaluation of bioorthogonal reactions in live cells with clickable Halo Tag ligands: implications for intracellular imaging  Academic Article
• T-cell-receptor affinity and thymocyte positive selection  Academic Article
• T0901317 is a dual lxr/fxr agonist  Academic Article
• TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines  Academic Article
• TOX3 is expressed in mammary ER(+) epithelial cells and regulates ER target genes in luminal breast cancer  Academic Article
• Tagged versus untagged libraries - methods for the generation and screening of combinatorial chemical libraries  Academic Article
• Tailored ligand acceleration of the Cu-catalyzed azide-alkyne cycloaddition reaction: practical and mechanistic implications  Academic Article
• Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation  Academic Article
• Targeting b lymphoma with nanoparticles bearing glycan ligands of cd22  Academic Article
• Targeting heat shock proteins on cancer cells: Selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand  Academic Article
• Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening  Academic Article
• Tcr affinity and negative regulation limit autoimmunity  Academic Article
• The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist  Academic Article
• The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands  Academic Article
• The Drosophila G protein-coupled receptor, Methuselah, exhibits a promiscuous response to peptides  Academic Article
• The E-2.65 A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors  Academic Article
• The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells  Academic Article
• The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha  Academic Article
• The RCSB protein data bank: New resources for research and education  Academic Article
• The RCSB protein data bank: Redesigned web site and web services  Academic Article
• The REV-ERBs and RORs: Molecular links between circadian rhythms and lipid homeostasis  Academic Article
• The brain galanin receptors: targets for novel antidepressant drugs  Academic Article
• The coactivator lxxll nuclear receptor recognition motif  Academic Article
• The contactin-related protein FAR-2 defines Purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum  Academic Article
• The crystal structure of avian cd1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian cd1  Academic Article
• The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism  Academic Article
• The discovery of 3-(n-alkyl)aminopropylphosphonic acids as potent s1p receptor agonists  Academic Article
• The dynamic energy landscape of dihydrofolate reductase catalysis  Academic Article
• The dynamics of ligand-receptor interactions. Real-time analyses of association, dissociation, and internalization of an N-formyl peptide and its receptors on the human neutrophil  Academic Article
• The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor  Academic Article
• The genesis of high-throughput structure-based drug discovery using protein crystallography  Academic Article
• The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand  Academic Article
• The importance of hydrophobic interactions in the antagonist binding to the muscarinic acetylcholine receptor  Academic Article
• The importance of ligand-receptor conformational pairs in stabilization: spotlight on the N/OFQ G protein-coupled receptor  Academic Article
• The importance of ligands for G protein-coupled receptor stability  Academic Article
• The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin  Academic Article
• The interleukin-1 system: Receptors, ligands, and ICE in the brain and their involvement in the fever response  Academic Article
• The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gamma delta T cell activation  Academic Article
• The leptin receptor system of human platelets  Academic Article
• The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry  Academic Article
• The mechanism of molecular redundancy in autoimmune inflammation in the context of CD44 deficiency  Academic Article
• The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins  Academic Article
• The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K  Academic Article
• The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor  Academic Article
• The nerve growth factor/tumor necrosis factor receptor family  Academic Article
• The nuclear receptor lxr is a glucose sensor  Academic Article
• The pharmacology of lxr  Academic Article
• The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster  Academic Article
• The privileged chemical space predictor (PCSP): A computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries  Academic Article
• The quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution  Academic Article
• The role of chelating diamine ligands in the goldberg reaction: a kinetic study on the copper-catalyzed amidation of aryl iodides  Academic Article
• The role of dynamic conformational ensembles in biomolecular recognition  Academic Article
• The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies  Academic Article
• The role of platelet adhesion receptor GPIb alpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis  Academic Article
• The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo  Academic Article
• The specificity of tcr/pmhc interaction  Academic Article
• The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae  Academic Article
• The structure, organization, activation and plasticity of the erythropoietin receptor  Academic Article
• The synthesis and in vivo evaluation of F-18 PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)  Academic Article
• The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs  Academic Article
• The tryptophan-derived ndogenous aryl hydrocarbon receptor ligand 6-formylindolo 3,2-b carbazole Is a nanomolar UVA photosensitizer in epidermal keratinocytes  Academic Article
• The type I interleukin-1 receptor mediates fever in the rat as shown by interleukin-1 receptor subtype selective ligands  Academic Article
• The type iii effector espf coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways  Academic Article
• The use of carbohydrate microarrays to study carbohydrate-cell interactions and to detect pathogens  Academic Article
• Themis sets the signal threshold for positive and negative selection in T-cell development  Academic Article
• Therapeutics targeting the innate immune system  Academic Article
• Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules  Academic Article
• Thiophene-core estrogen receptor ligands having superagonist activity  Academic Article
• Three-dimensional EM structure of the ectodomain of integrin alpha V beta 3 in a complex with fibronectin  Academic Article
• Three-dimensional structure of the ephb2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition  Academic Article
• Thymic selection by a single mhc/peptide ligand produces a semidiverse repertoire of cd4(+) t cells  Academic Article
• Thymic selection by a single mhc/peptide ligand: Autoreactive t cells are low-affinity cells  Academic Article
• Thymic selection threshold defined by compartmentalization of ras/mapk signalling  Academic Article
• Thymocyte expression of cathepsin L is essential for NKT cell development  Academic Article
• Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands  Academic Article
• Tight association of the human mel(1a)-melatonin receptor and g(i): Precoupling and constitutive activity  Academic Article
• Tissue factor signaling  Academic Article
• Tissue- and epitope-specific mechanisms account for the diverse effects of anti-CD44 antibodies on the maintenance of primitive hematopoietic progenitors in vitro  Academic Article
• Tlr4/md-2 monoclonal antibody therapy affords protection in experimental models of septic shock  Academic Article
• Toll-like receptor signaling inhibits hepatitis B virus replication in vivo  Academic Article
• Toll-like receptors in atherosclerosis  Academic Article
• Topographical distribution of redox centers and the q(o) site in ubiquinol-cytochrome-c oxidoreductase (complex-iii) and ligand structure of the rieske iron-sulfur cluster  Academic Article
• Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta(3) subunit  Academic Article
• Toward a rational design of peptide inhibitors of ribonucleotide reductase: structure-function and modeling studies  Academic Article
• Transduction of dendritic cells with Bcl-xL increases their resistance to prostate cancer-induced apoptosis and antitumor effect in mice  Academic Article
• Transformation of low-affinity lead compounds into high-affinity protein capture agents  Academic Article
• Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation  Academic Article
• Treatment with lxr agonists after focal cerebral ischemia prevents brain damage  Academic Article
• Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor  Academic Article
• Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures  Academic Article
• Tryptophan-accelerated electron flow through proteins  Academic Article
• Tumor regression by targeted gene delivery to the neovasculature  Academic Article
• Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (h-nox) domain  Academic Article
• Turning G proteins on and off using peptide ligands  Academic Article
• Two antigenically related neuronal cell adhesion molecules of different specificities mediate neuron-neuron and neuron-glia adhesion  Academic Article
• Two independent sets of monoclonal antibodies define neoepitopes linked to soluble ligand binding and leukocyte adhesion functions of activated alpha(M)beta(2)  Academic Article
• Two ligands may bind simultaneously to the muscarine receptor  Academic Article
• Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa  Academic Article
• Two-dimensional IR spectroscopy of protein dynamics using two vibrational labels: a site-specific genetically encoded unnatural amino acid and an active site ligand  Academic Article
• Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactions  Academic Article
• Two-dimensional combinatorial screening identifies specific 6 '-acylated kanamycin A- and 6 '-acylated neamine-RNA hairpin interactions  Academic Article
• Two-dimensional combinatorial screening identifies specific aminoglycoside - RNA internal loop partners  Academic Article
• UV and sunlight driven photoligation of quantum dots: understanding the photochemical transformation of the ligands  Academic Article
• Underscoring the influence of inorganic chemistry on nuclear imaging with radiometals  Academic Article
• Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase  Academic Article
• Unique ability of integrin alpha(v)beta(3) to support tumor cell arrest under dynamic flow conditions  Academic Article
• Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange  Academic Article
• Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops  Academic Article
• Unlocking nature's C-H bonds  Academic Article
• Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease iv  Academic Article
• Unusual arginine formations in protein function and assembly: Rings, strings, and stacks  Academic Article
• Uranyl ion coordination with rigid aromatic carboxylates and structural characterization of their complexes  Academic Article
• Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior  Academic Article
• Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling  Academic Article
• Use of phage display and transition-state analogs to select enzyme variants with altered catalytic properties: Glutathione transferase as an example  Academic Article
• Using AutoDock for ligand-receptor docking  Academic Article
• Using modularly assembled ligands to bind RNA internal loops separated by different distances  Academic Article
• Utility of redundant combinatorial libraries in distinguishing high and low quality screening hits  Academic Article
• Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention  Academic Article
• Vanadium-catalyzed asymmetric epoxidation of allylic alcohols in water  Academic Article
• Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue, and West Nile viruses  Academic Article
• Virtual screening for HIV protease inhibitors: a comparison of AutoDock 4 and Vina  Academic Article
• Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors  Academic Article
• Virtual screening of integrase inhibitors by large scale binding free energy calculations: the SAMPL4 challenge  Academic Article
• Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challenge  Academic Article
• What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?  Academic Article
• When does chemical elaboration induce a ligand to change its binding mode?  Academic Article
• X-ray structures of the LXRα LBD in its homodimeric form and implications for heterodimer signaling  Academic Article
• cDNA sequence, ligand biding, and regulation of galanin/GMAP in mouse brain  Academic Article
• αβ T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization  Academic Article