subject area of
- 13C NMR studies of the product complex of glyoxalase I Academic Article
- 2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations Academic Article
- 3D C(CC)H TOCSY experiment for assigning protons and carbons in uniformly 13C- and selectively 2H-labeled RNA Academic Article
- A DNA-based cancer vaccine enhances lymphocyte cross talk by engaging the nkg2d receptor Academic Article
- A LecA ligand identified from a galactoside-conjugate array inhibits host cell invasion by Pseudomonas aeruginosa Academic Article
- A bifunctional molecule that displays context-dependent cellular activity Academic Article
- A biomimetic polyketide-inspired approach to small-molecule ligand discovery Academic Article
- A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy Academic Article
- A chemical approach for detecting sulfenic acid-modified proteins in living cells Academic Article
- A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (ppar alpha) versus liver x receptor Academic Article
- A chemically induced vaccine strategy for prostate cancer Academic Article
- A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPAR gamma partial agonists Academic Article
- A cross-strand Trp-Trp pair stabilizes the hPin1 WW domain at the expense of function Academic Article
- A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome Academic Article
- A designed peptidomimetic agonistic ligand of trka nerve growth factor receptors Academic Article
- A dominant-negative peroxisome proliferator-activated receptor gamma (ppar gamma) mutant is a constitutive repressor and inhibits ppar gamma-mediated adipogenesis Academic Article
- A five-amino-acid motif in the undefined region of the tlr8 ectodomain is required for species-specific ligand recognition Academic Article
- A fluorinated ligand enables room-temperature and regioselective Pd-catalyzed fluorination of aryl triflates and bromides Academic Article
- A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking Academic Article
- A functional hot spot for antigen recognition in a superagonist TCR/MHC complex Academic Article
- A general fragment-based approach to identify and optimize bioactive ligands targeting RNA Academic Article
- A global benchmark study using affinity-based biosensors Academic Article
- A high-throughput ligand competition binding assay for the androgen receptor and other nuclear receptors Academic Article
- A labeled guanidine ligand for studying sweet taste Academic Article
- A liquid array platform for the multiplexed analysis of synthetic molecule-protein interactions Academic Article
- A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes - crystal structure of human leukocyte antigen (hla)-a1-mage-a1 in complex with fab-hyb3 Academic Article
- A maltose-binding protein fusion construct yields a robust crystallography platform for MCL1 Academic Article
- A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands Academic Article
- A metallopeptide assembly of the HIV-1 gp41 coiled coil is an ideal receptor in fluorescence detection of ligand binding Academic Article
- A molecular basis for no selectivity in soluble guanylate cyclase Academic Article
- A molecular model of RGD ligands. Antibody D gene segments that direct specificity for the integrin alpha IIb beta 3 Academic Article
- A molecular switch regulating transcriptional repression and activation of PPARγ Academic Article
- A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity Academic Article
- A natural product ligand of the oxysterol receptor, liver x receptor Academic Article
- A near-IR uncaging strategy based on cyanine photochemistry Academic Article
- A new approach to osmium-catalyzed asymmetric dihydroxylation and aminohydroxylation of olefins Academic Article
- A new mechanism of allostery in a G protein-coupled receptor dimer Academic Article
- A new spatial structure for the axial methionine observed in cytochrome c5 from pseudomonas-mendocina - correlations with the electronic-structure of heme-c Academic Article
- A novel method for analyzing extremely biased agonism at G protein-coupled receptors Academic Article
- A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests Academic Article
- A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects Academic Article
- A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity Academic Article
- A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site Academic Article
- A phosphoarginine containing peptide as an artificial SH2 ligand Academic Article
- A plant-like kinase in plasmodium falciparum regulates parasite egress from erythrocytes Academic Article
- A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding Academic Article
- A population of murine gamma delta T cells that recognize an inducible MHC class Ib molecule Academic Article
- A proximity based general method for identification of ligand and receptor interactions in living cells Academic Article
- A review of the human sigma-1 receptor structure Academic Article
- A rigid trans-spanning dinitrile ligand Academic Article
- A role for rev-erb alpha ligands in the regulation of adipogenesis Academic Article
- A role for tcr affinity in regulating naive t cell homeostasis Academic Article
- A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280 Academic Article
- A second endogenous cannabinoid that modulates long-term potentiation Academic Article
- A second-generation copper(II)-mediated metallo-DNA-base pair Academic Article
- A semiempirical free energy force field with charge-based desolvation Academic Article
- A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors Academic Article
- A slippery grip Academic Article
- A small molecule microarray platform to select RNA internal loop-ligand interactions Academic Article
- A sphingosine 1-phosphate receptor 2 selective allosteric agonist Academic Article
- A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA Academic Article
- A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states Academic Article
- A structure-activity study of nociceptin-(1-13)-peptide amide. Synthesis of analogues substituted in positions 0, 1, 3, 4 and 10 Academic Article
- A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype Academic Article
- A tetradentate ligand for the enantioselective Ti(IV)-promoted oxidation of sulfides to sulfoxides: origin of enantioselectivity Academic Article
- A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes Academic Article
- ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase Academic Article
- Ablation of cd22 in ligand-deficient mice restores b cell receptor signaling Academic Article
- Accelerated bioorthogonal conjugation: A practical method for the ligation of diverse functional molecules to a polyvalent virus scaffold Academic Article
- Acceleration of nucleophilic ch activation by strongly basic solvents Academic Article
- Action of RORs and their ligands in (patho)physiology Academic Article
- Activation of PPARdelta alters lipid metabolism in db/db mice Academic Article
- Activation of protein kinase c by phorbol dibutyrate modulates gaba(a) receptor binding in rat brain slices Academic Article
- Activation of the liver x receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy Academic Article
- Activators of the nuclear receptor ppar gamma enhance colon polyp formation Academic Article
- Adenosine: a partial agonist of the growth hormone secretagogue receptor Academic Article
- Adenovirus fiber shaft contains a trimerization element that supports peptide fusion for targeted gene delivery Academic Article
- Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling Academic Article
- Administration of recombinant p-selectin glycoprotein ligand fc fusion protein suppresses inflammation and neointimal formation in zucker diabetic rat model Academic Article
- Affinity-based ranking of ligands for DPP-4 from mixtures Academic Article
- Agonist-bound structure of the human P2Y(12) receptor Academic Article
- Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence Academic Article
- Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors Academic Article
- Allosteric inhibition of hypoxia inducible factor-2 with small molecules Academic Article
- Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists Academic Article
- Altered functional and biochemical response by CD8+ T cells that remain after tolerance Academic Article
- Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality Academic Article
- Aluminum-catalyzed asymmetric addition of TMSCN to aromatic and aliphatic ketones promoted by an easily accessible and recyclable peptide ligand Academic Article
- Amino-acid-sequence, hem-iron coordination geometry and functional-properties of mitochondrial and bacterial c-type cytochromes Academic Article
- Amyloid beta-peptide polymerization studied using fluorescence correlation spectroscopy Academic Article
- An "orphan" finds a home in NSC regulation Academic Article
- An NMR perspective on enzyme dynamics Academic Article
- An alkoxide-directed intermolecular 2+2+1 annulation: A three-component coupling reaction for the synthesis of tetrasubstituted alpha,beta,-unsaturated gamma-lactams Academic Article
- An alternate binding site for PPARγ ligands Academic Article
- An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket Academic Article
- An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation Academic Article
- An intense form of homeostatic proliferation of naive cd8(+) cells driven by il-2 Academic Article
- An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification Academic Article
- Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries Academic Article
- Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes Academic Article
- Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies Academic Article
- Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes Academic Article
- Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity Academic Article
- Antagonists of the kappa opioid receptor Academic Article
- Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR gamma by Cdk5 Academic Article
- Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides Academic Article
- Antibody domain exchange is an immunological solution to carbohydrate cluster recognition Academic Article
- Antibody remodeling - a general-solution to the design of a metal-coordination site in an antibody-binding pocket Academic Article
- Anticonvulsant activity of a nonpeptide galanin receptor agonist Academic Article
- Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation Academic Article
- Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis Academic Article
- Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry Academic Article
- Application of affinity selection/mass spectrometry to determine the structural isomer of parnafungins responsible for binding polyadenosine polymerase Academic Article
- Applications of laser-polarized (129)Xe to biomolecular assays Academic Article
- Approaches toward selective inhibition of nitric oxide synthase Academic Article
- Aptasensors for biosecurity applications Academic Article
- Area specificity and topography of thalamocortical projections are controlled by ephrin/eph genes Academic Article
- Arrest of beta-amyloid fibril formation by a pentapeptide ligand Academic Article
- Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor Academic Article
- Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein Academic Article
- Aspartate-transcarbamylase lacking catalytic subunit interactions - study of conformational-changes by uv absorbance and circular-dichroism spectroscopy Academic Article
- Assembly of PNA-tagged small molecules, peptides, and carbohydrates onto DNA templates: programming the combinatorial pairing and inter-ligand distance Academic Article
- Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1 Academic Article
- Association of neuronal calcium channels with modular adaptor proteins Academic Article
- Asymmetric total syntheses of aspidodasycarpine, lonicerine, and the proposed structure of lanciferine Academic Article
- Atherosclerosis induced by endogenous and exogenous toll-like receptor (tlr)1 or tlr6 agonists Academic Article
- AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings Academic Article
- AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading Academic Article
- AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility Academic Article
- AutoDock4(Zn): an improved AutoDock force field for small-molecule docking to zinc metalloproteins Academic Article
- AutoDockFR: Advances in protein-ligand docking with explicitly specified binding site flexibility Academic Article
- Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA Academic Article
- Autologous regulation of naive t cell homeostasis within the t cell compartment Academic Article
- Automated docking of flexible ligands: applications of AutoDock Academic Article
- Automated docking of ligands to an artificial active site: augmenting crystallographic analysis with computer modeling Academic Article
- Automated docking to multiple target structures: incorporation of protein mobility and structural water heterogeneity in AutoDock Academic Article
- Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase Academic Article
- Automated hydrogen/deuterium exchange electron transfer dissociation high resolution mass spectrometry measured at single-amide resolution Academic Article
- Automated prediction of ligand-binding sites in proteins Academic Article
- Avidity of cd1d-ligand-receptor ternary complex contributes to t-helper 1 (th1) polarization and anticancer efficacy Academic Article
- Aza-amino acid scanning of chromobox homolog 7 (CBX7) ligands Academic Article
- Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential Academic Article
- B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen Academic Article
- B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention Academic Article
- BRI1 is a critical component of a plasma-membrane receptor for plant steroids Academic Article
- Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery Academic Article
- Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation Academic Article
- Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off rags and promotes B cell-positive selection Academic Article
- Benzimidazole and related ligands for Cu-catalyzed azide-alkyne cycloaddition Academic Article
- Beyond protein binding: recent advances in screening DNA-encoded libraries Academic Article
- Beyond the ligand: extracellular and transcellular G protein-coupled receptor complexes in physiology and pharmacology Academic Article
- Biased signaling pathways in betaβ2-adrenergic receptor characterized by 19F-NMR Academic Article
- Bicyclic core estrogens as full antagonists: Synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides Academic Article
- Bifunctional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells Academic Article
- Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells Academic Article
- Binding and functional properties of concanavalin-a and its derivatives .3. Interactions with indoleacetic-acid and other hydrophobic ligands Academic Article
- Binding of alpha(2)-macroglobulin and limulin: Regulation of the plasma haemolytic system of the american horseshoe crab, limulus Academic Article
- Binding of proteins to cnbr-activated sepharose 4b Academic Article
- Biochemical and structural analysis of nuclear protein import Academic Article
- Biochemistry of soluble guanylate cyclase Academic Article
- Biocompatible click chemistry enabled compartment-specific pH measurement inside E-coli Academic Article
- Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors Academic Article
- Blocking transcription through a nucleosome with synthetic DNA ligands Academic Article
- BluB cannibalizes flavin to form the lower ligand of vitamin B-12 Academic Article
- Blue-fluorescent antibodies Academic Article
- Bmp signaling is required for development of primary lens fiber cells Academic Article
- Building synthetic antibodies as adhesive ligands for integrins Academic Article
- Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase Academic Article
- C5L2, a nonsignaling C5A binding protein Academic Article
- CCL3L1 and HIV/AIDS susceptibility Academic Article
- CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia Academic Article
- CD44 receptor unfolding enhances binding by freeing basic amino acids to contact carbohydrate ligand Academic Article
- CD8αα and ‐αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I Academic Article
- CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase Academic Article
- CSI-FID: high throughput label-free detection of DNA binding molecules Academic Article
- Carbon-deuterium bonds as probes of dihydrofolate reductase Academic Article
- Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis Academic Article
- Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: Crystal structures of abzyme 21D8 Academic Article
- Catalytic and regioselective ring expansion of arylcyclobutanones with trimethylsilyldiazomethane. Ligand-dependent entry to beta-ketosilane or enolsilane adducts Academic Article
- Catalyzed oxidative corrosion of porous silicon used as an optical transducer for ligand-receptor interactions Academic Article
- Cbp/p300 taz1 domain forms a structured scaffold for ligand binding Academic Article
- Cd22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of b cells Academic Article
- Cd62 and endothelial-cell leukocyte adhesion molecule-1 (elam-1) recognize the same carbohydrate ligand, sialyl-lewis-x Academic Article
- Cell surface biology mediated by low affinity multivalent protein-glycan interactions Academic Article
- Cell, isoform, and environment factors shape gradients and modulate chemotaxis Academic Article
- Changes in structure and dynamics of the fv fragment of a catalytic antibody upon binding of inhibitor Academic Article
- Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry Academic Article
- Characterization of pharmacologically active antipeptide antibodies directed against the first and 2nd extracellular loops of the serotonin 5-ht1a receptor Academic Article
- Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands Academic Article
- Characterization of the structure and function of W -> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding Academic Article
- Charting a path to success in virtual screening Academic Article
- Chemical approaches to nuclear receptors in metabolism Academic Article
- Chemical approaches to the lysophospholipid receptors Academic Article
- Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts Academic Article
- Chemical fragments as foundations for understanding target space and activity prediction Academic Article
- Chemical microarrays to identify ligands that bind pathogenic cells Academic Article
- Chemical probes of endocannabinoid metabolism Academic Article
- Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer Academic Article
- Chemically regulated zinc finger transcription factors Academic Article
- Chemistry and molecular biology of galanin receptor ligands Academic Article
- Chemoenzymatic synthesis of sialyl-trimeric-Lewis X Academic Article
- Chemoproteomic screening of covalent ligands reveals UBA5 as a novel pancreatic cancer target Academic Article
- Chemoproteomics reveals Toll-like receptor fatty acylation Academic Article
- Chemotype-selective modes of action of κ-opioid receptor agonists Academic Article
- Chronic nicotine treatment counteracts dopamine d-2 receptor up-regulation induced by a partial meso-diencephalic hemitransection in the rat Academic Article
- Classification of PDZ domains Academic Article
- Cloning, expression, and characterization of a nitric oxide synthase protein from deinococcus radiodurans Academic Article
- Closely related antibody receptors exploit fundamentally different strategies for steroid recognition Academic Article
- Coexpression of beta-1-adrenergic and beta-2-adrenergic receptors on bovine brain capillary endothelial-cells in culture Academic Article
- Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis Academic Article
- Combinatorial chemistry: A liquid-phase approach Academic Article
- Commensal bacteria make GPCR ligands that mimic human signalling molecules Academic Article
- Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008 Academic Article
- Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus Academic Article
- Comparison of intra- vs intermolecular long-range electron transfer in crystals of ruthenium-modified azurin Academic Article
- Computational fragment-based binding site identification by ligand competitive saturation Academic Article
- Computational functional group mapping for drug discovery Academic Article
- Computational protein-ligand docking and virtual drug screening with the AutoDock suite Academic Article
- Conformational changes in aspartate transcarbamylase. II. Circular dichroism evidence for the involvement of metal ions in allosteric interactions Academic Article
- Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding Academic Article
- Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions Academic Article
- Conformational effects in biological catalysis: an antibody-catalyzed oxy-Cope rearrangement Academic Article
- Conformational flexibility in the flap domains of ligand-free HIV protease Academic Article
- Conformational flexibility of b-DNA at 0.74 Å resolution: D(ccagtactgg)(2) Academic Article
- Conformational isomerism can limit antibody catalysis Academic Article
- Conformational states of the full-length glucagon receptor Academic Article
- Conserved binding mode of human beta(2) adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography Academic Article
- Conserved glycine 232 in the ligand channel of ba(3) cytochrome oxidase from Thermus thermophilus Academic Article
- Constitutive activity of the melanocortin-4 receptor is maintained by its n-terminal domain and plays a role in energy homeostasis in humans Academic Article
- Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c Academic Article
- Contemporary paradigms for cholinergic ligand design guided by biological structure Academic Article
- Controlling the architecture, coordination, and reactivity of nanoparticle coating utilizing an amino acid central scaffold Academic Article
- Cooperative binding of magnesium to transfer ribonucleic acid studied by a fluorescent probe Academic Article
- Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22 Academic Article
- Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies Academic Article
- Cortistatin a is a high-affinity ligand of protein kinases rock, cdk8, and cdk11 Academic Article
- Coumarin derivatives as substrate probes of mammalian cytochromes P450 2B4 and 2B6: assessing the importance of 7-Alkoxy chain length, halogen substitution, and non-active site mutations Academic Article
- Coupling of receptor conformation and ligand orientation determine graded activity Academic Article
- Covalent and 3-dimensional structure of concanavalin-a .3. Structure of monomer and its interactions with metals and saccharides Academic Article
- Covalent docking using autodock: two-point attractor and flexible side chain methods Academic Article
- Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products Academic Article
- Covalently-linked ligand stabilizes expression of heterodimeric receptor Academic Article
- Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling Academic Article
- Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex Academic Article
- Cryopreservation of postnatal rat retinal ganglion cells: persistence of voltage- and ligand-gated ionic currents Academic Article
- Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution Academic Article
- Crystal structure of S-adenosylmethionine : tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold Academic Article
- Crystal structure of a gamma delta t cell receptor ligand t22: A truncated mhc-like fold Academic Article
- Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution Academic Article
- Crystal structure of adenosine 5 '-phosphosulfate kinase from Penicillium chrysogenum Academic Article
- Crystal structure of antagonist bound human lysophosphatidic acid receptor 1 Academic Article
- Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening Academic Article
- Crystal structure of human cytochrome p450 2d6 with prinomastat bound Academic Article
- Crystal structure of human toll-like receptor 3 (tlr3) ectodomain Academic Article
- Crystal structure of mouse cd1: An mhc-like fold with a large hydrophobic binding groove Academic Article
- Crystal structure of mouse cd1d bound to the self ligand phosphatidylcholine: A molecular basis for nkt cell activation Academic Article
- Crystal structure of soluble md-1 and its interaction with lipid iva Academic Article
- Crystal structure of the Frizzled 4 receptor in a ligand-free state Academic Article
- Crystal structure of the TCR co-receptor CD8 alpha alpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution Academic Article
- Crystal structure of the human 4-1BB/4-1BBL complex Academic Article
- Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of camp-dependent protein kinase Academic Article
- Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892 Academic Article
- Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor Academic Article
- Crystal structures of apolipoprotein(a) kringle iv37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: Existence of novel and expected binding modes Academic Article
- Crystal structures of cytochrome p450 2b4 in complex with the inhibitor 1-biphenyl-4-methyl-1h-imidazole: Ligand-induced structural response through alpha-helical repositioning Academic Article
- Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands Academic Article
- Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain Academic Article
- Crystallization of murine major histocompatibility complex class-i h-2kb with single peptides Academic Article
- Curariform antagonists bind in different orientations to acetylcholine-binding protein Academic Article
- Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins Academic Article
- Cutting edge: Trimolecular interaction of tcr with mhc class ii and bacterial superantigen shows a similar affinity to mhc : Peptide ligands Academic Article
- Cutting edge: dendritic epidermal gamma delta T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding Academic Article
- Cyclic and linear oligocarbamate ligands for human thrombin Academic Article
- Cyclin-dependent kinases 5 template: useful for virtual screening Academic Article
- Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site Academic Article
- Cytokine receptor dimerization and activation: prospects for small molecule agonists Academic Article
- Cytotactin and its proteoglycan ligand mark structural and functional boundaries in somatosensory cortex of the early postnatal mouse Academic Article
- Cytotoxicity of quantum dots used for in vitro cellular labeling: role of QD surface ligand, delivery modality, cell type, and direct comparison to organic fluorophores Academic Article
- DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid Academic Article
- DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex Academic Article
- DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands Academic Article
- DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia Academic Article
- DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the nkg2d receptor Academic Article
- DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor Academic Article
- Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo Academic Article
- Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex Academic Article
- Defective lymphotoxin-β receptor-induced NF-κB transcriptional activity in NIK-deficient mice Academic Article
- Defining the communication between agonist and coactivator binding in the retinoid X receptor alpha ligand binding domain Academic Article
- Defining the conditional basis of silicon phthalocyanine near-IR ligand exchange Academic Article
- Defining the rna internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis Academic Article
- Deletion mutants of human interleukin 1β with significantly reduced agonist properties: Search for the agonist/antagonist switch in ligands to the interleukin 1 receptors Academic Article
- Delineation of the peptide binding site of the human galanin receptor Academic Article
- Delta(9)-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta(9)-tetrahydrocannabinol Academic Article
- Density functional calculation of pKa values and redox potentials in the bovine Rieske iron-sulfur protein Academic Article
- Density functional study of a mu-1,1-carboxylate bridged Fe(III)-O-Fe(IV) model complex. 2. Comparison with ribonucleotide reductase intermediate X Academic Article
- Derivation of a retinoid x receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1h-indol-3-yl)methyl-4-trifluoromethylbenzene Academic Article
- Design and synthesis of a rapamycin-based high-affinity binding fkbp12 ligands Academic Article
- Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching Academic Article
- Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant Academic Article
- Design of a selective chemical probe for class I PDZ domains Academic Article
- Design of molecular logic devices based on a programmable DNA-regulated semisynthetic enzyme Academic Article
- Design, synthesis and biological evaluation of nonpeptide integrin antagonists Academic Article
- Designing small-molecule switches for protein-protein interactions Academic Article
- Detailed analysis of grid-based molecular docking: a case study of CDOCKER - A CHARMm-based MD docking algorithm Academic Article
- Detailed analysis of the free and bound conformations of an antibody - x-ray structures of fab 17/9 and 3 different fab-peptide complexes Academic Article
- Detection of stealthy small amphiphilic biomarkers Academic Article
- Determinants of cytochrome P4502C8 substrate binding - structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid Academic Article
- Determinants of ligand affinity and heme reactivity in h-nox domains Academic Article
- Determinants of the heme-CO vibrational modes in the H-NOX family Academic Article
- Determination of fe-ligand bond lengths and the fe-n-o bond angles in soybean ferrous and ferric nitrosylleghemoglobin alpha using multiple-scattering xafs analyses Academic Article
- Developing ligands for palladium(II)-catalyzed C-H functionalization: intimate dialogue between ligand and substrate Academic Article
- Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor Academic Article
- Development of Pseudomonas aeruginosa lectin LecA inhibitor by using bivalent galactosides supported on polyproline peptide scaffolds Academic Article
- Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3) Academic Article
- Development of an intact cell reporter gene beta-lactamase assay for g protein-coupled receptors for high-throughput screening Academic Article
- Development of antibody surrogates for the treatment of cancers and autoimmune disease Academic Article
- Development of functionally selective, small molecule agonists at kappa opioid receptors Academic Article
- Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy Academic Article
- Development of protein-detecting microarrays and related devices Academic Article
- Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: Defining the binding mode of 7-oxabicyclo 2.2.1 hept-5-ene scaffold core ligands Academic Article
- Dextran as a generally applicable multivalent scaffold for improving immunoglobulin-binding affinities of peptide and peptidomimetic ligands Academic Article
- Diastereo- and enantioselective iridium-catalyzed allylation of cyclic ketone enolates: synergetic effect of ligands and barium enolates Academic Article
- Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands Academic Article
- Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively Academic Article
- Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions Academic Article
- Direct adenovirus-mediated IGF-l gene transduction of synovium induces persisting synovial fluid IGF-l ligand elevations Academic Article
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