Ligands

subject area of

13C NMR studies of the product complex of glyoxalase I Academic Article
2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations Academic Article
3D C(CC)H TOCSY experiment for assigning protons and carbons in uniformly 13C- and selectively 2H-labeled RNA Academic Article
A DNA-based cancer vaccine enhances lymphocyte cross talk by engaging the nkg2d receptor Academic Article
A LecA ligand identified from a galactoside-conjugate array inhibits host cell invasion by Pseudomonas aeruginosa Academic Article
A bifunctional molecule that displays context-dependent cellular activity Academic Article
A biomimetic polyketide-inspired approach to small-molecule ligand discovery Academic Article
A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy Academic Article
A chemical approach for detecting sulfenic acid-modified proteins in living cells Academic Article
A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (ppar alpha) versus liver x receptor Academic Article
A chemically induced vaccine strategy for prostate cancer Academic Article
A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPAR gamma partial agonists Academic Article
A cross-strand Trp-Trp pair stabilizes the hPin1 WW domain at the expense of function Academic Article
A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome Academic Article
A designed peptidomimetic agonistic ligand of trka nerve growth factor receptors Academic Article
A dominant-negative peroxisome proliferator-activated receptor gamma (ppar gamma) mutant is a constitutive repressor and inhibits ppar gamma-mediated adipogenesis Academic Article
A five-amino-acid motif in the undefined region of the tlr8 ectodomain is required for species-specific ligand recognition Academic Article
A fluorinated ligand enables room-temperature and regioselective Pd-catalyzed fluorination of aryl triflates and bromides Academic Article
A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking Academic Article
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex Academic Article
A global benchmark study using affinity-based biosensors Academic Article
A high-throughput ligand competition binding assay for the androgen receptor and other nuclear receptors Academic Article
A labeled guanidine ligand for studying sweet taste Academic Article
A liquid array platform for the multiplexed analysis of synthetic molecule-protein interactions Academic Article
A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes - crystal structure of human leukocyte antigen (hla)-a1-mage-a1 in complex with fab-hyb3 Academic Article
A maltose-binding protein fusion construct yields a robust crystallography platform for MCL1 Academic Article
A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands Academic Article
A metallopeptide assembly of the HIV-1 gp41 coiled coil is an ideal receptor in fluorescence detection of ligand binding Academic Article
A molecular basis for no selectivity in soluble guanylate cyclase Academic Article
A molecular model of RGD ligands. Antibody D gene segments that direct specificity for the integrin alpha IIb beta 3 Academic Article
A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity Academic Article
A natural product ligand of the oxysterol receptor, liver x receptor Academic Article
A near-IR uncaging strategy based on cyanine photochemistry Academic Article
A new approach to osmium-catalyzed asymmetric dihydroxylation and aminohydroxylation of olefins Academic Article
A new mechanism of allostery in a G protein-coupled receptor dimer Academic Article
A new spatial structure for the axial methionine observed in cytochrome c5 from pseudomonas-mendocina - correlations with the electronic-structure of heme-c Academic Article
A novel method for analyzing extremely biased agonism at G protein-coupled receptors Academic Article
A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests Academic Article
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects Academic Article
A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity Academic Article
A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site Academic Article
A phosphoarginine containing peptide as an artificial SH2 ligand Academic Article
A plant-like kinase in plasmodium falciparum regulates parasite egress from erythrocytes Academic Article
A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding Academic Article
A population of murine gamma delta T cells that recognize an inducible MHC class Ib molecule Academic Article
A proximity based general method for identification of ligand and receptor interactions in living cells Academic Article
A review of the human sigma-1 receptor structure Academic Article
A rigid trans-spanning dinitrile ligand Academic Article
A role for rev-erb alpha ligands in the regulation of adipogenesis Academic Article
A role for tcr affinity in regulating naive t cell homeostasis Academic Article
A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280 Academic Article
A second endogenous cannabinoid that modulates long-term potentiation Academic Article
A second-generation copper(II)-mediated metallo-DNA-base pair Academic Article
A semiempirical free energy force field with charge-based desolvation Academic Article
A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors Academic Article
A slippery grip Academic Article
A small molecule microarray platform to select RNA internal loop-ligand interactions Academic Article
A sphingosine 1-phosphate receptor 2 selective allosteric agonist Academic Article
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA Academic Article
A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states Academic Article
A structure-activity study of nociceptin-(1-13)-peptide amide. Synthesis of analogues substituted in positions 0, 1, 3, 4 and 10 Academic Article
A tetradentate ligand for the enantioselective Ti(IV)-promoted oxidation of sulfides to sulfoxides: origin of enantioselectivity Academic Article
A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes Academic Article
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase Academic Article
Ablation of cd22 in ligand-deficient mice restores b cell receptor signaling Academic Article
Accelerated bioorthogonal conjugation: A practical method for the ligation of diverse functional molecules to a polyvalent virus scaffold Academic Article
Acceleration of nucleophilic ch activation by strongly basic solvents Academic Article
Action of RORs and their ligands in (patho)physiology Academic Article
Activation of PPARdelta alters lipid metabolism in db/db mice Academic Article
Activation of protein kinase c by phorbol dibutyrate modulates gaba(a) receptor binding in rat brain slices Academic Article
Activation of the liver x receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy Academic Article
Activators of the nuclear receptor ppar gamma enhance colon polyp formation Academic Article
Adenosine: a partial agonist of the growth hormone secretagogue receptor Academic Article
Adenovirus fiber shaft contains a trimerization element that supports peptide fusion for targeted gene delivery Academic Article
Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling Academic Article
Administration of recombinant p-selectin glycoprotein ligand fc fusion protein suppresses inflammation and neointimal formation in zucker diabetic rat model Academic Article
Affinity-based ranking of ligands for DPP-4 from mixtures Academic Article
Agonist-bound structure of the human P2Y(12) receptor Academic Article
Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence Academic Article
Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors Academic Article
Allosteric inhibition of hypoxia inducible factor-2 with small molecules Academic Article
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists Academic Article
Altered functional and biochemical response by CD8+ T cells that remain after tolerance Academic Article
Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality Academic Article
Aluminum-catalyzed asymmetric addition of TMSCN to aromatic and aliphatic ketones promoted by an easily accessible and recyclable peptide ligand Academic Article
Amino-acid-sequence, hem-iron coordination geometry and functional-properties of mitochondrial and bacterial c-type cytochromes Academic Article
Amyloid beta-peptide polymerization studied using fluorescence correlation spectroscopy Academic Article
An "orphan" finds a home in NSC regulation Academic Article
An NMR perspective on enzyme dynamics Academic Article
An alkoxide-directed intermolecular 2+2+1 annulation: A three-component coupling reaction for the synthesis of tetrasubstituted alpha,beta,-unsaturated gamma-lactams Academic Article
An alternate binding site for PPARγ ligands Academic Article
An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket Academic Article
An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation Academic Article
An intense form of homeostatic proliferation of naive cd8(+) cells driven by il-2 Academic Article
An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification Academic Article
Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries Academic Article
Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes Academic Article
Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies Academic Article
Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes Academic Article
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity Academic Article
Antagonists of the kappa opioid receptor Academic Article
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR gamma by Cdk5 Academic Article
Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides Academic Article
Antibody domain exchange is an immunological solution to carbohydrate cluster recognition Academic Article
Antibody remodeling - a general-solution to the design of a metal-coordination site in an antibody-binding pocket Academic Article
Anticonvulsant activity of a nonpeptide galanin receptor agonist Academic Article
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation Academic Article
Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis Academic Article
Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry Academic Article
Application of affinity selection/mass spectrometry to determine the structural isomer of parnafungins responsible for binding polyadenosine polymerase Academic Article
Applications of laser-polarized (129)Xe to biomolecular assays Academic Article
Approaches toward selective inhibition of nitric oxide synthase Academic Article
Aptasensors for biosecurity applications Academic Article
Area specificity and topography of thalamocortical projections are controlled by ephrin/eph genes Academic Article
Arrest of beta-amyloid fibril formation by a pentapeptide ligand Academic Article
Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor Academic Article
Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein Academic Article
Aspartate-transcarbamylase lacking catalytic subunit interactions - study of conformational-changes by uv absorbance and circular-dichroism spectroscopy Academic Article
Assembly of PNA-tagged small molecules, peptides, and carbohydrates onto DNA templates: programming the combinatorial pairing and inter-ligand distance Academic Article
Association of neuronal calcium channels with modular adaptor proteins Academic Article
Asymmetric total syntheses of aspidodasycarpine, lonicerine, and the proposed structure of lanciferine Academic Article
Atherosclerosis induced by endogenous and exogenous toll-like receptor (tlr)1 or tlr6 agonists Academic Article
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading Academic Article
AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility Academic Article
AutoDock4(Zn): an improved AutoDock force field for small-molecule docking to zinc metalloproteins Academic Article
AutoDockFR: Advances in protein-ligand docking with explicitly specified binding site flexibility Academic Article
Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA Academic Article
Autologous regulation of naive t cell homeostasis within the t cell compartment Academic Article
Automated docking of flexible ligands: applications of AutoDock Academic Article
Automated docking of ligands to an artificial active site: augmenting crystallographic analysis with computer modeling Academic Article
Automated docking to multiple target structures: incorporation of protein mobility and structural water heterogeneity in AutoDock Academic Article
Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase Academic Article
Automated hydrogen/deuterium exchange electron transfer dissociation high resolution mass spectrometry measured at single-amide resolution Academic Article
Automated prediction of ligand-binding sites in proteins Academic Article
Avidity of cd1d-ligand-receptor ternary complex contributes to t-helper 1 (th1) polarization and anticancer efficacy Academic Article
Aza-amino acid scanning of chromobox homolog 7 (CBX7) ligands Academic Article
Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential Academic Article
B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen Academic Article
B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention Academic Article
BRI1 is a critical component of a plasma-membrane receptor for plant steroids Academic Article
Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery Academic Article
Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation Academic Article
Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off rags and promotes B cell-positive selection Academic Article
Benzimidazole and related ligands for Cu-catalyzed azide-alkyne cycloaddition Academic Article
Beyond protein binding: recent advances in screening DNA-encoded libraries Academic Article
Beyond the ligand: extracellular and transcellular G protein-coupled receptor complexes in physiology and pharmacology Academic Article
Biased signaling pathways in betaβ2-adrenergic receptor characterized by 19F-NMR Academic Article
Bicyclic core estrogens as full antagonists: Synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides Academic Article
Bifunctional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells Academic Article
Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells Academic Article
Binding and functional properties of concanavalin-a and its derivatives .3. Interactions with indoleacetic-acid and other hydrophobic ligands Academic Article
Binding of alpha(2)-macroglobulin and limulin: Regulation of the plasma haemolytic system of the american horseshoe crab, limulus Academic Article
Binding of proteins to cnbr-activated sepharose 4b Academic Article
Biochemical and structural analysis of nuclear protein import Academic Article
Biochemistry of soluble guanylate cyclase Academic Article
Biocompatible click chemistry enabled compartment-specific pH measurement inside E-coli Academic Article
Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors Academic Article
Blocking transcription through a nucleosome with synthetic DNA ligands Academic Article
BluB cannibalizes flavin to form the lower ligand of vitamin B-12 Academic Article
Blue-fluorescent antibodies Academic Article
Bmp signaling is required for development of primary lens fiber cells Academic Article
Building synthetic antibodies as adhesive ligands for integrins Academic Article
Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase Academic Article
C5L2, a nonsignaling C5A binding protein Academic Article
CCL3L1 and HIV/AIDS susceptibility Academic Article
CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia Academic Article
CD44 receptor unfolding enhances binding by freeing basic amino acids to contact carbohydrate ligand Academic Article
CD8αα and ‐αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I Academic Article
CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase Academic Article
CSI-FID: high throughput label-free detection of DNA binding molecules Academic Article
Carbon-deuterium bonds as probes of dihydrofolate reductase Academic Article
Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis Academic Article
Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: Crystal structures of abzyme 21D8 Academic Article
Catalytic and regioselective ring expansion of arylcyclobutanones with trimethylsilyldiazomethane. Ligand-dependent entry to beta-ketosilane or enolsilane adducts Academic Article
Catalyzed oxidative corrosion of porous silicon used as an optical transducer for ligand-receptor interactions Academic Article
Cbp/p300 taz1 domain forms a structured scaffold for ligand binding Academic Article
Cd22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of b cells Academic Article
Cd62 and endothelial-cell leukocyte adhesion molecule-1 (elam-1) recognize the same carbohydrate ligand, sialyl-lewis-x Academic Article
Cell surface biology mediated by low affinity multivalent protein-glycan interactions Academic Article
Cell, isoform, and environment factors shape gradients and modulate chemotaxis Academic Article
Changes in structure and dynamics of the fv fragment of a catalytic antibody upon binding of inhibitor Academic Article
Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry Academic Article
Characterization of pharmacologically active antipeptide antibodies directed against the first and 2nd extracellular loops of the serotonin 5-ht1a receptor Academic Article
Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands Academic Article
Characterization of the structure and function of W -> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding Academic Article
Charting a path to success in virtual screening Academic Article
Chemical approaches to nuclear receptors in metabolism Academic Article
Chemical approaches to the lysophospholipid receptors Academic Article
Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts Academic Article
Chemical fragments as foundations for understanding target space and activity prediction Academic Article
Chemical microarrays to identify ligands that bind pathogenic cells Academic Article
Chemical probes of endocannabinoid metabolism Academic Article
Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer Academic Article
Chemically regulated zinc finger transcription factors Academic Article
Chemistry and molecular biology of galanin receptor ligands Academic Article
Chemoenzymatic synthesis of sialyl-trimeric-Lewis X Academic Article
Chemoproteomic screening of covalent ligands reveals UBA5 as a novel pancreatic cancer target Academic Article
Chemotype-selective modes of action of κ-opioid receptor agonists Academic Article
Chronic nicotine treatment counteracts dopamine d-2 receptor up-regulation induced by a partial meso-diencephalic hemitransection in the rat Academic Article
Classification of PDZ domains Academic Article
Cloning, expression, and characterization of a nitric oxide synthase protein from deinococcus radiodurans Academic Article
Closely related antibody receptors exploit fundamentally different strategies for steroid recognition Academic Article
Coexpression of beta-1-adrenergic and beta-2-adrenergic receptors on bovine brain capillary endothelial-cells in culture Academic Article
Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis Academic Article
Combinatorial chemistry: A liquid-phase approach Academic Article
Commensal bacteria make GPCR ligands that mimic human signalling molecules Academic Article
Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008 Academic Article
Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus Academic Article
Comparison of intra- vs intermolecular long-range electron transfer in crystals of ruthenium-modified azurin Academic Article
Computational fragment-based binding site identification by ligand competitive saturation Academic Article
Computational functional group mapping for drug discovery Academic Article
Computational protein-ligand docking and virtual drug screening with the AutoDock suite Academic Article
Conformational changes in aspartate transcarbamylase. II. Circular dichroism evidence for the involvement of metal ions in allosteric interactions Academic Article
Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding Academic Article
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions Academic Article
Conformational effects in biological catalysis: an antibody-catalyzed oxy-Cope rearrangement Academic Article
Conformational flexibility in the flap domains of ligand-free HIV protease Academic Article
Conformational flexibility of b-DNA at 0.74 Å resolution: D(ccagtactgg)(2) Academic Article
Conformational isomerism can limit antibody catalysis Academic Article
Conformational states of the full-length glucagon receptor Academic Article
Conserved binding mode of human beta(2) adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography Academic Article
Conserved glycine 232 in the ligand channel of ba(3) cytochrome oxidase from Thermus thermophilus Academic Article
Constitutive activity of the melanocortin-4 receptor is maintained by its n-terminal domain and plays a role in energy homeostasis in humans Academic Article
Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c Academic Article
Contemporary paradigms for cholinergic ligand design guided by biological structure Academic Article
Controlling the architecture, coordination, and reactivity of nanoparticle coating utilizing an amino acid central scaffold Academic Article
Cooperative binding of magnesium to transfer ribonucleic acid studied by a fluorescent probe Academic Article
Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22 Academic Article
Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies Academic Article
Cortistatin a is a high-affinity ligand of protein kinases rock, cdk8, and cdk11 Academic Article
Coumarin derivatives as substrate probes of mammalian cytochromes P450 2B4 and 2B6: assessing the importance of 7-Alkoxy chain length, halogen substitution, and non-active site mutations Academic Article
Coupling of receptor conformation and ligand orientation determine graded activity Academic Article
Covalent and 3-dimensional structure of concanavalin-a .3. Structure of monomer and its interactions with metals and saccharides Academic Article
Covalent docking using autodock: two-point attractor and flexible side chain methods Academic Article
Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products Academic Article
Covalently-linked ligand stabilizes expression of heterodimeric receptor Academic Article
Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling Academic Article
Cryopreservation of postnatal rat retinal ganglion cells: persistence of voltage- and ligand-gated ionic currents Academic Article
Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution Academic Article
Crystal structure of S-adenosylmethionine : tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold Academic Article
Crystal structure of a gamma delta t cell receptor ligand t22: A truncated mhc-like fold Academic Article
Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution Academic Article
Crystal structure of adenosine 5 '-phosphosulfate kinase from Penicillium chrysogenum Academic Article
Crystal structure of antagonist bound human lysophosphatidic acid receptor 1 Academic Article
Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening Academic Article
Crystal structure of human cytochrome p450 2d6 with prinomastat bound Academic Article
Crystal structure of human toll-like receptor 3 (tlr3) ectodomain Academic Article
Crystal structure of mouse cd1: An mhc-like fold with a large hydrophobic binding groove Academic Article
Crystal structure of mouse cd1d bound to the self ligand phosphatidylcholine: A molecular basis for nkt cell activation Academic Article
Crystal structure of soluble md-1 and its interaction with lipid iva Academic Article
Crystal structure of the Frizzled 4 receptor in a ligand-free state Academic Article
Crystal structure of the TCR co-receptor CD8 alpha alpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution Academic Article
Crystal structure of the human 4-1BB/4-1BBL complex Academic Article
Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of camp-dependent protein kinase Academic Article
Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892 Academic Article
Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor Academic Article
Crystal structures of apolipoprotein(a) kringle iv37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: Existence of novel and expected binding modes Academic Article
Crystal structures of cytochrome p450 2b4 in complex with the inhibitor 1-biphenyl-4-methyl-1h-imidazole: Ligand-induced structural response through alpha-helical repositioning Academic Article
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands Academic Article
Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain Academic Article
Crystallization of murine major histocompatibility complex class-i h-2kb with single peptides Academic Article
Curariform antagonists bind in different orientations to acetylcholine-binding protein Academic Article
Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins Academic Article
Cutting edge: Trimolecular interaction of tcr with mhc class ii and bacterial superantigen shows a similar affinity to mhc : Peptide ligands Academic Article
Cutting edge: dendritic epidermal gamma delta T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding Academic Article
Cyclic and linear oligocarbamate ligands for human thrombin Academic Article
Cyclin-dependent kinases 5 template: useful for virtual screening Academic Article
Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site Academic Article
Cytokine receptor dimerization and activation: prospects for small molecule agonists Academic Article
Cytotactin and its proteoglycan ligand mark structural and functional boundaries in somatosensory cortex of the early postnatal mouse Academic Article
Cytotoxicity of quantum dots used for in vitro cellular labeling: role of QD surface ligand, delivery modality, cell type, and direct comparison to organic fluorophores Academic Article
DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid Academic Article
DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex Academic Article
DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands Academic Article
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia Academic Article
DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the nkg2d receptor Academic Article
Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo Academic Article
Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex Academic Article
Defective lymphotoxin-β receptor-induced NF-κB transcriptional activity in NIK-deficient mice Academic Article
Defining the communication between agonist and coactivator binding in the retinoid X receptor alpha ligand binding domain Academic Article
Defining the conditional basis of silicon phthalocyanine near-IR ligand exchange Academic Article
Defining the rna internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis Academic Article
Deletion mutants of human interleukin 1β with significantly reduced agonist properties: Search for the agonist/antagonist switch in ligands to the interleukin 1 receptors Academic Article
Delineation of the peptide binding site of the human galanin receptor Academic Article
Delta(9)-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta(9)-tetrahydrocannabinol Academic Article
Density functional calculation of pKa values and redox potentials in the bovine Rieske iron-sulfur protein Academic Article
Density functional study of a mu-1,1-carboxylate bridged Fe(III)-O-Fe(IV) model complex. 2. Comparison with ribonucleotide reductase intermediate X Academic Article
Derivation of a retinoid x receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1h-indol-3-yl)methyl-4-trifluoromethylbenzene Academic Article
Design and synthesis of a rapamycin-based high-affinity binding fkbp12 ligands Academic Article
Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching Academic Article
Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant Academic Article
Design of a selective chemical probe for class I PDZ domains Academic Article
Design of molecular logic devices based on a programmable DNA-regulated semisynthetic enzyme Academic Article
Design, synthesis and biological evaluation of nonpeptide integrin antagonists Academic Article
Designing small-molecule switches for protein-protein interactions Academic Article
Detailed analysis of grid-based molecular docking: a case study of CDOCKER - A CHARMm-based MD docking algorithm Academic Article
Detailed analysis of the free and bound conformations of an antibody - x-ray structures of fab 17/9 and 3 different fab-peptide complexes Academic Article
Detection of stealthy small amphiphilic biomarkers Academic Article
Determinants of cytochrome P4502C8 substrate binding - structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid Academic Article
Determinants of ligand affinity and heme reactivity in h-nox domains Academic Article
Determinants of the heme-CO vibrational modes in the H-NOX family Academic Article
Determination of fe-ligand bond lengths and the fe-n-o bond angles in soybean ferrous and ferric nitrosylleghemoglobin alpha using multiple-scattering xafs analyses Academic Article
Developing ligands for palladium(II)-catalyzed C-H functionalization: intimate dialogue between ligand and substrate Academic Article
Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor Academic Article
Development of Pseudomonas aeruginosa lectin LecA inhibitor by using bivalent galactosides supported on polyproline peptide scaffolds Academic Article
Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3) Academic Article
Development of an intact cell reporter gene beta-lactamase assay for g protein-coupled receptors for high-throughput screening Academic Article
Development of antibody surrogates for the treatment of cancers and autoimmune disease Academic Article
Development of functionally selective, small molecule agonists at kappa opioid receptors Academic Article
Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy Academic Article
Development of protein-detecting microarrays and related devices Academic Article
Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: Defining the binding mode of 7-oxabicyclo 2.2.1 hept-5-ene scaffold core ligands Academic Article
Dextran as a generally applicable multivalent scaffold for improving immunoglobulin-binding affinities of peptide and peptidomimetic ligands Academic Article
Diastereo- and enantioselective iridium-catalyzed allylation of cyclic ketone enolates: synergetic effect of ligands and barium enolates Academic Article
Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands Academic Article
Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively Academic Article
Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions Academic Article
Direct adenovirus-mediated IGF-l gene transduction of synovium induces persisting synovial fluid IGF-l ligand elevations Academic Article
Direct comparison of linear and macrocyclic compound libraries as a source of protein ligands Academic Article
Direct observation of ligand dynamics in cytochrome c Academic Article
Direct production of proteins with N-terminal cysteine for site-specific conjugation Academic Article
Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries Academic Article
Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library Academic Article
Discovery of light-responsive ligands through screening of a light-responsive genetically encoded library Academic Article
Discovery of manassantin A protein targets using large-scale protein folding and stability measurements Academic Article
Discovery of peptoid ligands for anti-aquaporin 4 antibodies Academic Article
Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor's potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations Academic Article
Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase Academic Article
Discovery of selective RIO2 kinase small molecule ligand Academic Article
Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase i7l using homology modeling and covalent docking approaches Academic Article
Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist Academic Article
Disorder-to-order transition of the active site of human class Pi glutathione transferase, GST P1-1 Academic Article
Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1 alpha/ERR gamma complex Academic Article
Disruption of tissue-specific fucosyltransferase vii, an enzyme necessary for selectin ligand synthesis, suppresses atherosclerosis in mice Academic Article
Dissection of the insulin-sensitizing effect of liver x receptor ligands Academic Article
Distinct endocytic mechanisms of cd22 (siglec-2) and siglec-f reflect roles in cell signaling and innate immunity Academic Article
Distinct footprints of tcr engagement with highly homologous ligands Academic Article
Distinguishing binders from false positives by free energy calculations: fragment screening against the flap site of HIV protease Academic Article
Distributed automated docking of flexible ligands to proteins: parallel applications of AutoDock 2.4 Academic Article
Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity Academic Article
Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors Academic Article
Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors Academic Article
Diversity and modularity of g protein-coupled receptor structures Academic Article
Diving into the water: inducible binding conformations for BRD4, TAF1(2), BRD9, and CECR2 bromodomains Academic Article
Division of labor of schwann cell integrins during migration on peripheral nerve extracellular matrix ligands Academic Article
Do active site conformations of small ligands correspond to low free-energy solution structures? Academic Article
DoMCoSAR: A novel approach for establishing the docking mode that is consistent with the structure-activity relationship. Application to HIV-1 protease inhibitors and VEGF receptor tyrosine kinase inhibitors Academic Article
Docking molecules by families to increase the diversity of hits in database screens: Computational strategy and experimental evaluation Academic Article
Donor- and ligand-dependent differences in C-C chemokine receptor 5 reexpression Academic Article
Dosage delivery of sensitive reagents enables glove-box-free synthesis Academic Article
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis Academic Article
Dynamic conformational equilibria in the physiological function of the Bombyx mori pheromone-binding protein Academic Article
Dynamic structure of retinylidene ligand of rhodopsin probed by molecular simulations Academic Article
Dynamics of the dihydrofolate-reductase folate complex - catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features Academic Article
Effect of novel nociceptin/orphanin FQ-NOP receptor ligands on ethanol drinking in alcohol-preferring msP rats Academic Article
Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing Academic Article
Effects of foxo4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake Academic Article
Effects of mutations on the partitioning of DNA substrates between the polymerase and 3 '-5 ' exonuclease sites of DNA polymerase i (klenow fragment) Academic Article
Efficient synthesis of 1-sulfonyl-1,2,3-triazoles Academic Article
Elam-1 mediates cell-adhesion by recognition of a carbohydrate ligand, sialyl-lex Academic Article
Electrochemically protected copper(i)-catalyzed azide-alkyne cycloaddition Academic Article
Electron crystallographic analysis of two-dimensional streptavidin crystals coordinated to metal-chelated lipid monolayers Academic Article
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16 Academic Article
Elemental isomerism: A boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands Academic Article
Elucidating the mechanism of the asymmetric aza-Michael reaction Academic Article
Emerging insights in tissue factor-dependent signaling events Academic Article
Empirical entropic contributions in computational docking: evaluation in APS reductase complexes Academic Article
Encapsulating an immunosuppressant enhances tolerance induction by Siglec-engaging tolerogenic liposomes Academic Article
Endogenous and synthetic ABHD5 ligands regulate ABHD5-perilipin interactions and lipolysis in fat and muscle Academic Article
Endothelins stimulate tyrosine phosphorylation and activity of p42/mitogen-activated protein-kinase in astrocytes Academic Article
Energetic contributions and topographical organization of ligand-binding residues of tissue factor Academic Article
Engineering GPCR signaling pathways with RASSLs Academic Article
Engineering a periplasmic binding protein for amino acid sensors with improved binding properties Academic Article
Engineering naturally occurring trans-acting non-coding RNAs to sense molecular signals Academic Article
Engineering the polyproline II propensity of a class II major histocompatibility complex ligand peptide Academic Article
Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulation type IIFN signaling Academic Article
Enthalpy arrays Academic Article
Erythropoietin receptor activation by a ligand-induced conformation change Academic Article
Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus Academic Article
Essential role of stromally induced hedgehog signaling in B-cell malignancies Academic Article
Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor Academic Article
Evaluation of rna-binding specificity of aminoglycosides with DNA microarrays Academic Article
Evidence for an intermediate conformational state of lacy Academic Article
Evolution and protein packaging of small-molecule rna aptamers Academic Article
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template Academic Article
Excision of a proposed electron transfer pathway in cytochrome c peroxidase and its replacement by a ligand-binding channel Academic Article
Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes Academic Article
Expression of 3 human beta-adrenergic-receptor subtypes in transfected chinese-hamster ovary cells Academic Article
Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor Academic Article
Extraordinarily slow binding of guanosine to the Tetrahymena group I ribozyme: Implications for RNA preorganization and function Academic Article
Fabrication of highly stable glyco-gold nanoparticles and development of a glyco-gold nanoparticle-based oriented immobilized antibody microarray for lectin (GOAL) assay Academic Article
Facile access to modified and functionalized PNAs through Ugi-based solid phase oligomerization Academic Article
Factors affecting binding of galacto ligands to Actinomyces-viscosus lectin Academic Article
False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform Academic Article
Fast docking on graphics processing units via Ray-Casting Academic Article
Flavonol activation defines an unanticipated ligand-binding site in the kinase-rnase domain of ire1 Academic Article
Flipdock: Docking flexible ligands into flexible receptors Academic Article
Fluoresceinated chemotactic peptide and high-affinity anti-fluorescein antibody as a probe of the temporal characteristics of neutrophil stimulation Academic Article
Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a Academic Article
Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging: what we know and what we need to learn Academic Article
Fmoc solid phase synthesis of polyamides containing pyrrole and imidazole amino acids Academic Article
FoldGPCR: Structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A Academic Article
Folic acid-mediated targeting of cowpea mosaic virus particles to tumor cells Academic Article
Forced folding of a disordered protein accesses an alternative folding landscape Academic Article
From opiate pharmacology to opioid peptide physiology Academic Article
From pharmacotherapy to pathophysiology: Emerging mechanisms of apolipoprotein d in psychiatric disorders Academic Article
Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions Academic Article
Functional expression of the human serotonin 5-ht1a receptor in escherichia-coli - ligand-binding properties and interaction with recombinant g-protein alpha-subunits Academic Article
Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation Academic Article
G protein-coupled receptor endocytosis confers uniformity in responses to chemically distinct ligands Academic Article
G-protein-directed ligand discovery with peptide combinatorial libraries Academic Article
GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex Academic Article
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function Academic Article
GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import Academic Article
Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes Academic Article
Galanin receptor ligands Academic Article
Galanin receptors from human pituitary tumors assayed with human galanin as ligand Academic Article
Galanin, galanin receptors, and drug targets Academic Article
Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes Academic Article
Galanin: Neurobiologic mechanisms and therapeutic potential for Alzheimer's disease Academic Article
Galnon - a low-molecular weight ligand of the galanin receptors Academic Article
Gangliosides interact directly with plasminogen and urokinase and may mediate binding of these fibrinolytic components to cells Academic Article
Gas6, a ligand for the receptor protein-tyrosine kinase Tyro-3, is widely expressed in the central nervous system Academic Article
Gene mediated insulin-like growth factor-i delivery to the synovium Academic Article
Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template Academic Article
Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity Academic Article
Genetically encoded fragment-based discovery of glycopeptide ligands for carbohydrate-binding proteins Academic Article
Genotypes of nk cell kir receptors, their ligands, and fc gamma receptors in the response of neuroblastoma patients to hu14.18-il2 immunotherapy Academic Article
Geranylgeranyl switching regulates GDI-Rab GTPase recycling Academic Article
Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates alzheimer's disease-related neuropathies: Involvement of non-amyloidogenic processing Academic Article
Globotriose-functionalized gold nanoparticles as multivalent probes for Shiga-like toxin Academic Article
Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain Academic Article
Glutathione transferases with novel active sites isolated by phage display from a library of random mutants Academic Article
Glycomimetic ligands for the human asialoglycoprotein receptor Academic Article
H-1-NMR studies of heme pocket conformation in zinc-substituted leghemoglobin, a diamagnetic analog of deoxyleghemoglobin Academic Article
H-nox-mediated nitric oxide sensing modulates symbiotic colonization by vibrio fischeri Academic Article
HCV NS5A and IRF9 compete for CypA binding Academic Article
HDX reveals unique fragment ligands for the vitamin D receptor Academic Article
HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection Academic Article
HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria Academic Article
High affinity binding of conformationally constrained synthetic oligomers to an antigen-specific antibody: Discovery of a diagnostically useful synthetic ligand for murine Type 1 diabetes autoantibodies Academic Article
High affinity sialoside ligands of myelin associated glycoprotein Academic Article
High affinity targets of protein kinase inhibitors have similar residues at the positions energetically important for binding Academic Article
High molecular-weight kininogen binds to mac-1 on neutrophils by its heavy-chain (domain-3) and its light-chain (domain-5) Academic Article
High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA Academic Article
High specificity in response of the sodium-dependent multivitamin transporter to derivatives of pantothenic acid Academic Article
High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways Academic Article
High-affinity ligand probes of cd22 overcome the threshold set by cis ligands for binding, endocytosis, and killing of b cells Academic Article
High-affinity self-reactive human-antibodies by design and selection - targeting the integrin ligand-binding site Academic Article
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Academic Article
High-resolution definition of vaccine-elicited b cell responses against the hiv primary receptor binding site Academic Article
High-throughput functional affinity purification of mannose binding proteins from Oryza sativa Academic Article
High-throughput ligand screening via preclustering and evolved neural networks Academic Article
Higher order iminodiacetic acid libraries for probing protein-protein interactions Academic Article
Highly selective cyclic peptide ligands for NeutrAvidin and avidin identified by phage display Academic Article
Histamine H3 receptor as a drug discovery target Academic Article
Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix Academic Article
How ligands illuminate GPCR molecular pharmacology Academic Article
Human beta-2-adrenergic receptors expressed in escherichia-coli membranes retain their pharmacological properties Academic Article
Human neural cell adhesion molecule l1 and rat homologue nile are ligands for integrin alpha(v)beta(3) Academic Article
Hydrodynamic, electron-microscopic, and ligand-binding analysis of the epstein-barr virus c3dg receptor (cr-2) Academic Article
Hydrogen-bonded capsules in water Academic Article
Hydrogen/deuterium-exchange (H/D-Ex) of PPAR gamma LBD in the presence of various modulators Academic Article
Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity Academic Article
Hypothalamic degradation of galanin(1-29) and galanin(1-16): identification and characterization of the peptidolytic products Academic Article
Hypothesized role of galactocerebroside and NKT cells in the etiology of multiple sclerosis Academic Article
IL-8/CXCL8 and growth-related oncogene α/CXCL1 induce chondrocyte hypertrophic differentiation Academic Article
Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha 8 beta 1 in the embryonic kidney Academic Article
Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin d receptor modulators Academic Article
Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors Academic Article
Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo 2.2.1 hept-2-ene-7-oxide Academic Article
Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the α2δ-1 subunit of voltage gated calcium channel Academic Article
Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ Academic Article
Identification of SR2211: a potent synthetic ROR gamma-selective modulator Academic Article
Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist Academic Article
Identification of Siglec ligands using a proximity labeling method Academic Article
Identification of a novel conformationally constrained glucagon receptor antagonist Academic Article
Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein Academic Article
Identification of a novel integrin binding-site in fibronectin - differential utilization by beta-3 integrins Academic Article
Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors Academic Article
Identification of a region in the integrin beta 3 subunit that confers ligand binding specificity Academic Article
Identification of a selective ROR gamma ligand that suppresses T(H)17 cells and stimulates T regulatory cells Academic Article
Identification of an N-formyl peptide receptor ligand binding domain by a gain-of-function approach Academic Article
Identification of critical ligand binding determinants in Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase Academic Article
Identification of drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions Academic Article
Identification of endogenous ligands bound to bacterially expressed human and E. coli dihydrofolate reductase by 2D NMR Academic Article
Identification of heme as the ligand for the orphan nuclear receptors rev-erb alpha and rev-erb beta Academic Article
Identification of histidine 105 in the beta 1 subunit of soluble guanylate cyclase as the heme proximal ligand Academic Article
Identification of ligands and coligands for the ecdysone-regulated gene switch Academic Article
Identification of osteopontin as a novel ligand for the integrin alpha 8 beta 1 and potential roles for this integrin-ligand interaction in kidney morphogenesis Academic Article
Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand Academic Article
Identification of the first synthetic steroidogenic factor 1 inverse agonists: Pharmacological modulation of steroidogenic enzymes Academic Article
Identification of the low density lipoprotein (ldl) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris Academic Article
Identification of the zinc ligands in cobalamin-independent methionine synthase (MetE) from Escherichia coli Academic Article
Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for gpcr modulators Academic Article
Identifying protein stabilizing ligands using GroEL Academic Article
Imidazole-imidazole pair as a minor groove recognition motif for T:G mismatched base pairs Academic Article
Immobilized peptides as high-affinity capture agents for self-associating proteins Academic Article
Immunochemistry of the hepatitis B virus: 125I HB Ag ligand Academic Article
Impact of long-term androgen deprivation therapy on PSMA ligand PET/CT in patients with castration-sensitive prostate cancer Academic Article
Impedance responses reveal β₂-adrenergic receptor signaling pluridimensionality and allow classification of ligands with distinct signaling profiles Academic Article
Important pharmacophores for binding to galanin receptor 2 Academic Article
Improved syntheses of phosphine ligands by direct coupling of diarylbromophosphine with organometallic reagents Academic Article
In silica-aided design of a glycan ligand of sialoadhesin for in vivo targeting of macrophages Academic Article
In silico screening against wild-type and mutant Plasmodium falciparum dihydrofolate reductase Academic Article
In situ trans ligands of CD22 identified by glycan-protein photocross-linking-enabled proteomics Academic Article
In vitro evolution of nucleic acids Academic Article
In vivo brain GPCR signaling elucidated by phosphoproteomics Academic Article
In vivo targeting of b-cell lymphoma with glycan ligands of cd22 Academic Article
In vivo, in vitro, and molecular aspects of interleukin-8 and the interleukin-8 receptors Academic Article
Increasing the efficacy of bioorthogonal click reactions for bioconjugation: a comparative study Academic Article
Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry Academic Article
Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides Academic Article
Inhibition of Delta-induced Notch signaling using fucose analogs Academic Article
Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-kappa B, and DNA by a designed DNA-binding ligand Academic Article
Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands Academic Article
Inhibition of t cell receptor-coreceptor interactions by antagonist ligands visualized by live fret imaging of the t-hybridoma immunological synapse Academic Article
Insights into PPAR gamma from structures with endogenous and covalently bound ligands Academic Article
Instant immunity through chemically programmable vaccination and covalent self-assembly Academic Article
Integrin activation controls metastasis in human breast cancer Academic Article
Integrin alpha 8 beta 1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis Academic Article
Integrin alpha 8 beta 1 promotes attachment, cell spreading, and neurite outgrowth on fibronectin Academic Article
Integrin-mediated regulation of synaptic morphology, transmission, and plasticity Academic Article
Interaction of the taz1 domain of the creb-binding protein with the activation domain of cited2 - regulation by competition between intrinsically unstructured ligands for non-identical binding sites Academic Article
Interactions between redox complexes and semiconductor quantum dots coupled via a peptide bridge Academic Article
Interactions of soluble recombinant integrin alpha v beta 5 with human adenoviruses Academic Article
Intrathecal administration of PNA targeting galanin receptor reduces galanin-mediated inhibitory effect in the rat spinal cord Academic Article
Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase Academic Article
Inverse agonist activity of steroidogenic factor SF-1 Academic Article
Investigating the dearomative rearrangement of biaryl phosphine-ligated Pd(II) complexes Academic Article
Investigation by site-directed mutagenesis of the role of cytochrome p450 2b4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme Academic Article
Investigation of the PDZ domain ligand binding site using chemically modified peptides Academic Article
Investigations on the 1-(2-biphenyl)piperazine motif: Identification of new potent and selective ligands for the serotonin(7) (5-ht7) receptor with agonist or antagonist action in vitro or ex vivo Academic Article
Involvement of an active-site Zn2+ ligand mechanism of human glyoxalase I Academic Article
Iron(II)-catalyzed intramolecular olefin aminofluorination Academic Article
Iron-sulfur cluster n5 is coordinated by an hxxxcxxcxxxxxc motif in the nuog subunit of escherichia coli nadh : Quinone oxidoreductase (complex i) Academic Article
Iron-sulfur clusters and protein-structure of azotobacter ferredoxin at 2.0 a resolution Academic Article
Isolation of protein ligands from large peptoid libraries Academic Article
Iterative in situ click chemistry creates antibody-like protein-capture agents Academic Article
Key mechanistic features of enantioselective c-h bond activation reactions catalyzed by (chiral mono-n-protected amino acid)-pd(ii) complexes Academic Article
Kinetic and stoichiometric characterisation of streptavidin-binding aptamers Academic Article
Kinetic stabilization of an oligomeric protein by a single ligand binding event Academic Article
Kinetic stabilization of the native state by protein engineering: Implications for inhibition of transthyretin amyloidogenesis Academic Article
L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding Academic Article
LCP-Tm: An assay to measure and understand stability of membrane proteins in a membrane environment Academic Article
Label-free detection of biomolecular interactions using BioLayer Interferometry for kinetic characterization Academic Article
Label-free quantification of membrane-ligand interactions using backscattering interferometry Academic Article
Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response Academic Article
Lessons in molecular recognition. 2. Assessing and improving cross-docking accuracy Academic Article
Lessons in molecular recognition: The effects of ligand and protein flexibility on molecular docking accuracy Academic Article
Ligand access to the active site in thermus thermophilus ba(3) and bovine heart aa(3) cytochrome oxidases Academic Article
Ligand accessibility to the HIV-1 Env co-receptor binding site can occur prior to CD4 engagement and is independent of viral tier category Academic Article
Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans Academic Article
Ligand activation of ERRα by cholesterol mediates statin and bisphosphonate effects Academic Article
Ligand and coactivator identity determines the requirement of the charge clamp for coactivation of the peroxisome proliferator-activated receptor gamma Academic Article
Ligand and receptor dynamics contribute to the mechanism of graded PPAR gamma agonism Academic Article
Ligand binding and inhibition of an oxygen-sensitive soluble guanylate cyclase, gyc-88e, from drosophila Academic Article
Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues Academic Article
Ligand control of coregulator recruitment to nuclear receptors Academic Article
Ligand dimerization programmed by hybridization to study multimeric ligand-receptor interactions Academic Article
Ligand discrimination in soluble guanylate cyclase and the h-nox family of heme sensor proteins Academic Article
Ligand profiling and identification technology for searching bioactive ligands Academic Article
Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics Academic Article
Ligand specificity of h-nox domains: From sgc to bacterial no sensors Academic Article
Ligand-accelerated C-H activation reactions: evidence for a switch of mechanism Academic Article
Ligand-accelerated Cu-catalyzed azide-alkyne cycloaddition: a mechanistic report Academic Article
Ligand-accelerated cross-coupling of C(sp2)-H bonds with arylboron reagents Academic Article
Ligand-accelerated ortho-C-H alkylation of arylcarboxylic acids using alkyl boron reagents Academic Article
Ligand-binding dynamics rewire cellular signaling via estrogen receptor-alpha Academic Article
Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening Academic Article
Ligand-bound S = 1/2 FeMo-cofactor of nitrogenase: hyperfine interaction analysis and implication for the central ligand X identity Academic Article
Ligand-controlled C(sp(3))-H arylation and olefination in synthesis of unnatural chiral alpha-amino acids Academic Article
Ligand-dependent coactivation of the human bile acid receptor fxr by the peroxisome proliferator-activated receptor gamma coactivator-1 alpha Academic Article
Ligand-dependent exponential amplification of a self-replicating L-RNA enzyme Academic Article
Ligand-dependent perturbation of the conformational ensemble for the GPCR beta(2) adrenergic receptor revealed by HDX Academic Article
Ligand-dependent regulation of retinoic acid receptor alpha in rat testis: In vivo response to depletion and repletion of vitamin A Academic Article
Ligand-enabled cross-coupling of C(sp(3))-H bonds with arylboron reagents via Pd(II)/Pd(0) catalysis Academic Article
Ligand-enabled cross-coupling of C(sp(3))-H bonds with arylsilanes Academic Article
Ligand-enabled gamma-C-H olefination and carbonylation: construction of beta-quaternary carbon centers Academic Article
Ligand-enabled meta-C-H activation using a transient mediator Academic Article
Ligand-enabled meta-C-H alkylation and arylation using a modified norbornene Academic Article
Ligand-enabled methylene C(sp3)-H bond activation with a Pd(II) catalyst Academic Article
Ligand-enabled reactivity and selectivity in a synthetically versatile aryl C-H olefination Academic Article
Ligand-enabled triple C-H activation reactions: one-pot synthesis of diverse 4-aryl-2-quinolinones from propionamides Academic Article
Ligand-enabled β-C-H arylation of α-amino acids using a simple and practical auxiliary Academic Article
Ligand-enabled γ-C(sp(3))-H olefination of amines: en route to pyrrolidines Academic Article
Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor Academic Article
Ligand-guided receptor optimization Academic Article
Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor Academic Article
Ligand-induced and nonfusogenic dissolution of a viral membrane Academic Article
Ligand-induced conformational changes in the bacillus subtilis chemoreceptor mcpb determined by disulfide crosslinking in vivo Academic Article
Ligand-induced conformational changes observed in single RNA molecules Academic Article
Ligand-induced internalization of the epidermal growth-factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors Academic Article
Ligand-induced protease receptor translocation into caveolae: A mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway Academic Article
Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation Academic Article
Ligand-mediated retargeting of recombinant adenovirus for gene transfer in vivo Academic Article
Ligand-promoted alkylation of C(sp(3))-H and C(sp(2))-H bonds Academic Article
Ligand-promoted borylation of C(sp(3))-H bonds with palladium(II) catalysts Academic Article
Ligand-promoted c-3 selective c-h olefination of pyridines with pd catalysts Academic Article
Ligand-promoted c3-selective arylation of pyridines with pd catalysts: Gram-scale synthesis of (+/-)-preclamol Academic Article
Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms Academic Article
Ligands in crystal structures that aid in functional characterization Academic Article
Ligands in psi structures Academic Article
Ligands of the neuropeptide Y Y2 receptor Academic Article
Ligands specify coactivator nuclear receptor (nr) box affinity for estrogen receptor subtypes Academic Article
Linking high-throughput screens to identify MoAs and novel inhibitors of Mycobacterium tuberculosis dihydrofolate reductase Academic Article
Lipid agonism: The PIP2 paradigm of ligand-gated ion channels Academic Article
Lipophilic regulator of a developmental switch in Caenorhabditis elegans Academic Article
Liver x receptor and retinoic x receptor mediated abca1 regulation and cholesterol efflux in macrophage cells - messenger rna measured by branched DNA technology Academic Article
Lysophospholipid receptor nomenclature review: IUPHAR Review 8 Academic Article
Lysophospholipid receptors: signaling and biology Academic Article
Lysosomal glycosphingolipid recognition by NKT cells Academic Article
MDB: The metalloprotein database and browser at The Scripps Research Institute Academic Article
MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist Academic Article
Magnetic circular dichroism spectroscopic characterization of the NOS-like protein from Geobacillus stearothermophilus (gsNOS) Academic Article
Magnetic circular-dichroism study of cytochrome-ba3 from thermus-thermophilus - spectral contributions from cytochrome-b and cytochrome-a3 and nanosecond spectroscopy of co photodissociation intermediates Academic Article
Malachite green mediates homodimerization of antibody VL domains to form a fluorescent ternary complex with singular symmetric interfaces Academic Article
Manipulation of thrombin exosite I, by ligand-directed covalent modification Academic Article
Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics Academic Article
Masking of cd22 by cis ligands does not prevent redistribution of cd22 to sites of cell contact Academic Article
Matrix valency regulates integrin-mediated lymphoid adhesion via syk kinase Academic Article
Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain Academic Article
Mechanism of the ligand-free Cu-I-catalyzed azide-alkyne cycloaddition reaction Academic Article
Mechanism-based profiling of enzyme families Academic Article
Mechanisms and consequences of affinity modulation of integrin alpha(v)beta(3) detected with a novel patch-engineered monovalent ligand Academic Article
Mechanisms imposing the V beta bias of V alpha 14 natural killer T cells and consequences for microbial glycolipid recognition Academic Article
Mechanisms of distribution and targeting of neuronal ion channels Academic Article
Mechanisms of nuclear-protein import Academic Article
Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery Academic Article
Mediation of most atypical effects by species homologs of the beta(3)-adrenoceptor Academic Article
Metal ligand substitution and evidence for quinone formation in taurine/alpha-ketoglutarate dioxygenase Academic Article
Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity Academic Article
Metalloantibodies Academic Article
Methionine ligand interaction in a blue copper protein characterized by site-selective infrared spectroscopy Academic Article
Methodology for protein-ligand binding studies: application to a model for drug resistance, the HIV/FIV protease system Academic Article
Mhc class ii engagement in brain endothelial cells induces protein kinase a-dependent il-6 secretion and phosphorylation of camp response element-binding protein Academic Article
Micro- and nanotechnologies for studying cellular function Academic Article
Mild and general methods for the palladium-catalyzed cyanation of aryl and heteroaryl chlorides Academic Article
Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands Academic Article
Minor groove DNA-protein contacts upstream of a tRNA gene detected with a synthetic DNA binding ligand Academic Article
Mixed-element capture agents: A simple strategy for the construction of synthetic, high-affinity protein capture ligands Academic Article
Model of the alpha L beta 2 integrin I-domain/ICAM-1 DI interface suggests that subtle changes in loop orientation determine ligand specificity Academic Article
Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies Academic Article
Modulating heme redox potential through protein-induced porphyrin distortion Academic Article
Modulation of HIF-2α PAS-B domain contributes to physiological responses Academic Article
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ib-alpha Academic Article
Molecular behavior in small spaces Academic Article
Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3 Academic Article
Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions Academic Article
Molecular control of delta-opioid receptor signalling Academic Article
Molecular determinants of Arg-Gly-Asp ligand specificity for beta(3) integrins Academic Article
Molecular determinants of lxr alpha agonism Academic Article
Molecular interactions at the t cell-antigen-presenting cell interface Academic Article
Molecular mechanism for switching of p-falciparum invasion pathways into human erythrocytes Academic Article
Molecular mechanism of lipopeptide presentation by cd1a Academic Article
Molecular recognition of 6 '-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches Academic Article
Morphology, motility, and surface behavior of lymphocytes bound to nylon fibers Academic Article
Mouse siglec-f and human siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6 '-sulfo-sialyl lewis x as a preferred glycan ligand Academic Article
Multidentate poly(ethylene glycol) ligands provide colloidal stability to semiconductor and metallic nanocrystals in extreme conditions Academic Article
Multifunctional compact zwitterionic ligands for preparing robust biocompatible semiconductor quantum dots and gold nanoparticles Academic Article
Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors Academic Article
Multiple interaction sites of galnon trigger its biological effects Academic Article
Multivalent and multifunctional ligands to β-amyloid Academic Article
Multivalent display and receptor-mediated endocytosis of transferrin on virus-like particles Academic Article
Murine pheromone proteins constitute a context-dependent combinatorial code governing multiple social behaviors Academic Article
Muscarinic acetylcholine receptor Academic Article
Mutagenesis and ligand modification studies on galanin binding to its GTP-binding-protein-coupled receptor GalR1 Academic Article
Mutation altering the function of a carbohydrate binding-protein blocks cell-cell cohesion in developing dictyostelium-discoideum Academic Article
Mutational analysis of ligand-binding activity of beta-2 adrenergic-receptor expressed in escherichia-coli Academic Article
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands Academic Article
N-CAM binding inhibits the proliferation of hippocampal progenitor cells and promotes their differentiation to a neuronal phenotype Academic Article
N-heterocyclic carbene ligand-enabled C(sp(3))-H arylation of piperidine and tetrahydropyran derivatives Academic Article
N-terminal galanin fragments inhibit the hippocampal release of acetylcholine in vivo Academic Article
NF kappa B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Academic Article
NMR observation of selected segments in a larger protein: Central-segment isotope labeling through intein-mediated ligation Academic Article
NMR solution structure of the inserted domain of human leukocyte function associated antigen-1 Academic Article
NMR solution structure of the isolated Apo Pin1 WW domain: comparison to the X-ray crystal structures of Pin1 Academic Article
NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor Academic Article
NMR structure of a cyclic polyamide-DNA complex Academic Article
Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2 Academic Article
Negative regulation of t cell receptor signaling by siglec-7 (p70/airm) and siglec-9 Academic Article
Negative regulation of the Apaf-1 apoptosome by Hsp70 Academic Article
Negative stain single-particle EM of the maltose transporter in nanodiscs reveals asymmetric closure of MalK2 and catalytic roles of ATP, MalE, and maltose Academic Article
Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease Academic Article
Neuron-glia cell-adhesion molecule interacts with neurons and astroglia via different binding mechanisms Academic Article
Neurotransmitter action - opening of ligand-gated ion channels Academic Article
New catalysts for the asymmetric hydrosilylation of ketones discovered by mass spectrometry screening Academic Article
New chemistry for the study of multiprotein complexes: The six-histidine tag as a receptor for a protein crosslinking reagent Academic Article
New insights into inhibitor design from the crystal structure and NMR studies of escherichia coli GAR and 10-formyl-5,8,10-trideazafolic acid Academic Article
New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling Academic Article
Nibbling at crf receptor control of feeding and gastrocolonic motility Academic Article
Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells Academic Article
Nmr detection of adventitious xylose binding to the quorum-sensing protein SdiA of Escherichia coli Academic Article
Nmr structure of the unliganded bombyx mori pheromone-binding protein at physiological ph Academic Article
Nociceptin/orphanin fq metabolism and bioactive metabolites Academic Article
Novel analogues of (R)-5-(methylamino)-5,6-dihydro-4H-imidazo 4,5,1-ij quinolin-2(1H)-one (sumanirole) provide clues to dopamine D-2/D-3 receptor agonist selectivity Academic Article
Novel approaches for targeting the adenosine A2A receptor Academic Article
Novel galanin receptor ligands Academic Article
Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects Academic Article
Novel pharmacological probes reveal ABHD5 as a locus of lipolysis control in white and brown adipocytess Academic Article
Novel selective allosteric and bitopic ligands for the S1P(3) receptor Academic Article
Novel systemically active galanin receptor 2 ligands in depression-like behavior Academic Article
Nuclear hormone receptors for heme: Rev-erb alpha and rev-erb beta are ligand-regulated components of the mammalian clock Academic Article
Nuclear magnetic resonance studies of a ribonuclease-dinucleoside phosphonate complex and their implications for the mechanism of the enzyme Academic Article
Nuclear receptor ligands and cofactor recruitment: is there a coactivator "on deck"? Academic Article
Nuclear receptors and their selective pharmacologic modulators Academic Article
Nuclear receptors, metabolism, and the circadian clock Academic Article
Nucleic acid encoding to program self-assembly in chemical biology Academic Article
Observation of covalent intermediates in an enzyme mechanism at atomic resolution Academic Article
Observations on the oxidation-reduction properties of bovine erythrocyte superoxide dismutase Academic Article
On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7 Academic Article
Open and closed conformations of two SpoiiAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding Academic Article
Opportunities for functional selectivity in gpcr antibodies Academic Article
Optimization of adenosine 5 '-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening Academic Article
Optimization of the magnetic recovery of hits from one-bead-one-compound library screens Academic Article
Optimized protocols for the isolation of specific protein-binding peptides or peptoids from combinatorial libraries displayed on beads Academic Article
Optimized translocator protein ligand for optical molecular imaging and screening Academic Article
Optochemical control of gene expression by photocaged guanine and riboswitches Academic Article
Organocatalytic enantioselective synthesis of metabotropic glutamate receptor ligands Academic Article
Osmolyte-, binding-, and temperature-induced transitions of intrinsically disordered proteins Academic Article
Oxygenation of hydrocarbons by cytochrome-p-450 model compounds - modification of reactivity by axial ligands Academic Article
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design Academic Article
PNA-encoded chemical libraries Academic Article
Palladium(II)-catalyzed enantioselective C(sp(3))-H activation using a chiral hydroxamic acid ligand Academic Article
Palladium-meta-terarylphosphine catalyst for the Mizoroki-Heck reaction of (hetero)aryl bromides and functional olefins Academic Article
Panning for snurms: Using cofactor profiling for the rational discovery of selective nuclear receptor modulators Academic Article
Paramagnetic proteoliposomes containing a pure, native, and oriented seven-transmembrane segment protein, CCR5 Academic Article
Partial agonists activate PPAR gamma using a helix 12 independent mechanism Academic Article
Paying the price for pathogen protection: Toll receptors in atherogenesis Academic Article
Pd(0)/PR(3)-catalzed intermolecular arylation of sp(3) C-H bonds Academic Article
Pd(II)-catalyzed C3-selective arylation of pyridine with (hetero)arenes Academic Article
Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes Academic Article
Pd(II)-catalyzed hydroxyl-directed C-H olefination enabled by monoprotected amino acid ligands Academic Article
Pd(ii)-catalyzed enantioselective activation of c(sp(2))-h and c(sp(3))-h bonds using monoprotected amino acids as chiral ligands Academic Article
Pd(ii)-catalyzed olefination of electron-deficient arenes using 2,6-dialkylpyridine ligands Academic Article
Peptide ligands for a sugar-binding protein isolated from a random peptide library Academic Article
Peptoid ligands that bind selectively to phosphoproteins Academic Article
Perception of brassinosteroids by the extracellular domain of the receptor kinase BRI1 Academic Article
Performance-enhancing effects of crf-bp ligand inhibitors Academic Article
Peroxisome proliferator-activated receptor (ppar) gamma coactivator-1 recruitment regulates ppar subtype specificity Academic Article
Perspectives: drug delivery - Regulating export of ER cargo Academic Article
Phage escape libraries for checkmate analysis Academic Article
Pharmacology of nuclear receptor-coregulator recognition Academic Article
Phenotypic and functional properties of human steady state CD14(+) and CD1a(+) antigen presenting cells and epidermal langerhans cells Academic Article
Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners Academic Article
Photo-induced oxidative cross-linking as a method to evaluate the specificity of protein-ligand interactions Academic Article
Picrotoxinin receptor ligand blocks anti-punishment effects of alcohol Academic Article
Piperidinyltetralin sigma ligands Academic Article
Plant receptor kinases: systemin receptor identified Academic Article
Plasma contains protein S monomers and multimers with similar direct anticoagulant activity Academic Article
Polyspecificity of t cell and b cell receptor recognition Academic Article
Polytriazoles as copper(I)-stabilizing ligands in catalysis Academic Article
Porphyrin π-stacking in a heme protein scaffold tunes gas ligand affinity Academic Article
Positive regulation of retinoic acid receptor alpha by protein kinase C and mitogen-activated protein kinase in sertoli cells Academic Article
Post-SELEX combinatorial optimization of aptamers Academic Article
Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies Academic Article
Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro Academic Article
Ppar gamma signaling exacerbates mammary gland tumor development Academic Article
Predicting PDZ domain-peptide interactions from primary sequences Academic Article
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method Academic Article
Preferential recognition of avian-like receptors in human influenza A H7N9 viruses Academic Article
Preparation of stable maleimide-functionalized Au nanoparticles and their use in counting surface ligands Academic Article
Printed covalent glycan array for ligand profiling of diverse glycan binding proteins Academic Article
Printing proteins as microarrays for high-throughput function determination Academic Article
Probing backbone hydrogen bonds in the hydrophobic core of GCN4 Academic Article
Probing domain interactions in soluble guanylate cyclase Academic Article
Probing ligand recognition in the decarboxylase antibody 21d8: Implications for the catalytic mechanism Academic Article
Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry Academic Article
Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: Structures of the escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products Academic Article
Probing the role of the vancomycin E-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues Academic Article
Processing of integrin αv subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase Academic Article
Production and detection of monoclonal anti-idiotype antibodies directed against a monoclonal anti-beta-adrenergic ligand antibody Academic Article
Programmed death-1 ligands-transfected dendritic cells loaded with glutamic acid decarboxylase 65 (GAD65) inhibit both the alloresponse and the GAD65-reactive lymphocyte response Academic Article
Progress in corticotropin-releasing factor-1 antagonist development Academic Article
Promotion of dendritic growth by CPG15, an activity-induced signaling molecule Academic Article
Protein S multimers and monomers each have direct anticoagulant activity Academic Article
Protein and Mg(2+)-induced conformational changes in the S15 binding site of 16 S ribosomal RNA Academic Article
Protein assembly directed by synthetic molecular recognition motifs Academic Article
Protein conformer selection by ligand binding observed with crystallography Academic Article
Protein dynamics and cytochrome c: Correlations between ligand vibrations and redox activity Academic Article
Protein flexibility in virtual screening: the BACE-1 case study Academic Article
Protein folding at single-molecule resolution Academic Article
Protein microarrays: Prospects and problems Academic Article
Protein-ligand docking with multiple flexible side chains Academic Article
Proteome-wide covalent ligand discovery in native biological systems Academic Article
Proton release due to manganese binding and oxidation in modified bacterial reaction centers Academic Article
Proton walk in the aqueous platinum complex tpptmeco via a sticky sigma-methane ligand Academic Article
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening Academic Article
Qualitative and quantitative differences in t cell receptor binding of agonist and antagonist ligands Academic Article
Quality control mechanisms during ribosome maturation Academic Article
Quantification of the vitamin D receptor-coregulator interaction Academic Article
Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP Academic Article
Quantum dots as a visual aid for screening bead-bound combinatorial libraries Academic Article
REV-ERB and ROR nuclear receptors as drug targets Academic Article
Rapid identification of improved protein ligands using peptoid microarrays Academic Article
Rapid identification of orexin receptor binding ligands using cell-based screening accelerated with magnetic beads Academic Article
Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry Academic Article
Rapid modulation of N-formyl chemotactic peptide receptors on the surface of human granulocytes: formation of high-affinity ligand-receptor complexes in transient association with cytoskeleton Academic Article
Rational and modular design of potent ligands targeting the rna that causes myotonic dystrophy 2 Academic Article
Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions Academic Article
Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: Application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3 Academic Article
Rational ligand design for the arylation of hindered primary amines guided by reaction progress kinetic analysis Academic Article
Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue Academic Article
Recent avian h5n1 viruses exhibit increased propensity for acquiring human receptor specificity Academic Article
Recent developments and applications of clickable photoprobes in medicinal chemistry and chemical biology Academic Article
Recent progress in the discovery of selective, non-peptide ligands of somatostatin receptors Academic Article
Receptor differential activation and cooperativity better explain cellular preference for different chemoattractant gradient shapes in an EGFR system Academic Article
Receptor for age (rage) mediates neointimal formation in response to arterial injury Academic Article
Receptor for motilin identified in the human gastrointestinal system Academic Article
Receptor rigidity and ligand mobility in trypsin-ligand complexes Academic Article
Receptor-based assays Academic Article
Receptor-templated stapling of intrinsically disordered peptide ligands Academic Article
Recognition and catalysis in allylic alkylations Academic Article
Recognition of microbial glycans by human intelectin-1 Academic Article
Recognition of physiological receptors by anti-idiotypic antibodies - molecular mimicry of the ligand or cross-reactivity Academic Article
Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands Academic Article
Recognition templates for predicting adenylate-binding sites in proteins Academic Article
Recombinant expression of tlr5 proteins by ligand supplementation and a leucine-rich repeat hybrid technique Academic Article
Recruitment of epidermal growth-factor and transferrin receptors into coated pits in-vitro - differing biochemical requirements Academic Article
Reevaluating the substrate specificity of the L-type amino acid transporter (LAT1) Academic Article
Refined crystallographic structure of pseudomonas aeruginosa exotoxin a and its implications for the molecular mechanism of toxicity Academic Article
Regioselective base-free intermolecular aminohydroxylations of hindered and functionalized alkenes Academic Article
Regulation of Pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor Academic Article
Regulation of adipogenesis by natural and synthetic REV-ERB ligands Academic Article
Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors Academic Article
Regulation of feeding by galnon Academic Article
Regulation of skin cell homeostasis by gamma delta T cells Academic Article
Relationships between structure and activities of concanavalin a Academic Article
Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure Academic Article
Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 2. Effects on heme coordination and function Academic Article
Resin-supported catalysts for CuAAC click reactions in aqueous or organic solvents Academic Article
Resonance raman spectra of an o2-binding h-nox domain reveal heme relaxation upon mutation Academic Article
Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network Academic Article
Reversible photocontrol of biological systems by the incorporation of molecular photoswitches Academic Article
Rhenium(vii) oxide catalyzed heteroacylative ring-opening dimerization of tetrahydrofuran Academic Article
Rhodium-catalyzed and zinc(II)-triflate-promoted asymmetric hydrogenation of tetrasubstituted α,β-unsaturated ketones Academic Article
Robust scoring functions for protein-ligand interactions with quantum chemical charge models Academic Article
Role of N-acyl amino acid ligands in Pd(II)-catalyzed remote C-H activation of tethered arenes Academic Article
Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase Academic Article
Role of cell-surface lysines in plasminogen binding to cells: identification of alpha-enolase as a candidate plasminogen receptor Academic Article
Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity - Different oligomers activate different signal transduction pathways Academic Article
Role of electrostatic interactions in PDZ domain ligand recognition Academic Article
Role of self-major histocompatibility complex/peptide ligands in selection and maintenance of a diverse t cell repertoire Academic Article
S1p(1)-selective in vivo-active agonists from high-throughput screening: Off-the-shelf chemical probes of receptor interactions, signaling, and fate Academic Article
SDOCKER: A method utilizing existing X-ray structures to improve docking accuracy Academic Article
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities Academic Article
Scaffold composition and biological relevance of screening libraries Academic Article
Scorpion-toxin mimics of cd4 in complex with human immunodeficiency virus gp120: Crystal structures, molecular mimicry, and neutralization breadth Academic Article
Screening a peptidyl database for potential ligands to proteins with side-chain flexibility Academic Article
Screening transthyretin amyloid fibril inhibitors: Characterization of novel multiprotein, multiligand complexes by mass spectrometry Academic Article
Seamless bead to microarray screening: Rapid identification of the highest affinity protein ligands from large combinatorial libraries Academic Article
Second-generation DBFOX ligands for the synthesis of β-substituted α-amino acids via enantioselective radical conjugate additions Academic Article
Selection and application of peptide-binding peptides Academic Article
Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells Academic Article
Selection of phage-displayed peptides that bind to a particular ligand-bound antibody Academic Article
Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening Academic Article
Selective inhibition of oncogenic KRAS output with small molecules targeting the inactive state Academic Article
Selective recognition and extraction of the uranyl ion Academic Article
Selective recognition of oligomeric hiv-1 primary isolate envelope glycoprotelins by potently neutralizing ligands requires efficient precursor cleavage Academic Article
Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy Academic Article
Selective toxin sequestrants for the treatment of bacterial infections Academic Article
Sensitizer-linked substrates and ligands: Ruthenium probes of cytochrome P450 structure and mechanism Academic Article
Serotonin 5-ht(7) receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders Academic Article
Sialoside analogue arrays for rapid identification of high affinity siglec ligands Academic Article
Siglecs as sensors of self in innate and adaptive immune responses Academic Article
Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells Academic Article
Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer Academic Article
Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma Academic Article
Signal transduction and ligand-receptor dynamics in the human neutrophil. Transient responses and occupancy-response relations at the formyl peptide receptor Academic Article
Silver(I)-promoted conversion of thioamides to amidines: divergent synthesis of a key series of vancomycin aglycon residue 4 amidines that clarify binding behavior to model ligands Academic Article
Simicon: A web tool for protein-ligand model comparison through calculation of equivalent atomic contacts Academic Article
Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands Academic Article
Single-particle EM reveals plasticity of interactions between the adenovirus penton base and integrin alpha(V)beta(3) Academic Article
Site identification by Ligand Competitive Saturation (SILCS) simulations for fragment-based drug design Academic Article
Site-directed mutagenesis azotobacter-vinelandii ferredoxin-i - cysteine ligation of the 4fe-4s cluster with protein rearrangement is preferred over serine ligation Academic Article
Site-directed mutagenesis of the human beta(3)-adrenoceptor - transmembrane residues involved in ligand binding and signal transduction Academic Article
Site-selective C(sp3)-H functionalization of di-, tri-, and tetrapeptides at the N-terminus Academic Article
Site-specific protein modification through Cu-I-catalyzed 1,2,3-triazole formation and its implementation in protein microarray fabrication Academic Article
Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intron Academic Article
Small molecule modulation of nuclear receptor conformational dynamics: implications for function and drug discovery Academic Article
Small-molecule binding to an artificially created cavity at the active-site of cytochrome-c peroxidase Academic Article
Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity Academic Article
Smoke-derived karrikin perception by the α/β-hydrolase KAI2 from Arabidopsis Academic Article
Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2 Academic Article
Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids Academic Article
Soluble mimetics of human immunodeficiency virus type 1 viral spikes produced by replacement of the native trimerization domain with a heterologous trimerization motif: Characterization and ligand binding analysis Academic Article
Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain Academic Article
Solution structure by 2D 1H-NMR of a chimeric peptide recognized by galanin and neuropeptide Y receptors Academic Article
Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP Academic Article
Solution-phase synthesis of combinatorial libraries designed to modulate protein-protein or protein-DNA interactions Academic Article
Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control Academic Article
Spectral and ligand-binding properties of an unusual hemoprotein, the ferric form of soluble guanylate cyclase Academic Article
Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from vibrio cholerae and thermoanaerobacter tengcongensis Academic Article
Sphingosine 1-phosphate pathway therapeutics: A lipid ligand-receptor paradigm Academic Article
Sphingosine-1-phosphate and its receptors: Structure, signaling, and influence Academic Article
Spin state and unfolding equilibria of ferricytochrome c in acidic solutions Academic Article
Split tolerance in peripheral B cell subsets in mice expressing a low level of Ig kappa-reactive ligand Academic Article
Stability of isoproterenol bound to cyanogen bromide-activated agarose Academic Article
Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function Academic Article
Structural analyses clarify the complex control of mistranslation by tRNA synthetases Academic Article
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1 Academic Article
Structural analysis of papain-like NlpC/p60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites Academic Article
Structural and biochemical characterization of the therapeutic anabaena variabilis phenylalanine ammonia lyase Academic Article
Structural and biophysical insights into the ligand-free Pitx2 homeodomain and a ring dermoid of the cornea inducing homeodomain mutant Academic Article
Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica Academic Article
Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors Academic Article
Structural basis for a disfavored elimination reaction in catalytic antibody 1D4 Academic Article
Structural basis for allosteric regulation of GPCRs by sodium ions Academic Article
Structural basis for high-affinity peptide inhibition of human Pin1 Academic Article
Structural basis for ligand recognition and discrimination of a quorum-quenching antibody Academic Article
Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway Academic Article
Structural basis for molecular recognition at serotonin receptors Academic Article
Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen Academic Article
Structural basis of single-nucleotide polymorphisms in cytochrome P450 2C9 Academic Article
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism Academic Article
Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica Academic Article
Structural characterization of the Z ring-eIF4E complex reveals a distinct mode of control for eIF4E Academic Article
Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the clostridium botulinum serotype a neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility Academic Article
Structural evaluation of potent NKT cell agonists: Implications for design of novel stimulatory ligands Academic Article
Structural features for functional selectivity at serotonin receptors Academic Article
Structural implications for the design of molecular vaccines Academic Article
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor Academic Article
Structural insights into neonatal Fc receptor-based recycling mechanisms Academic Article
Structural interpretation of lanthanide binding to basic pancreatic trypsin-inhibitor by h-1 NMR at 360 mhz Academic Article
Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus Academic Article
Structural plasticity and the evolution of antibody affinity and specificity Academic Article
Structural plasticity in the oestrogen receptor ligand-binding domain Academic Article
Structural properties of non-traditional drug targets present new challenges for virtual screening Academic Article
Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors Academic Article
Structurally homologous ligand-binding of integrin mac-1 and viral glycoprotein-c receptors Academic Article
Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor Academic Article
Structure and function of von Willebrand factor Academic Article
Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634 Academic Article
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors Academic Article
Structure and properties of a bis-histidyl ligated globin from caenorhabditis elegans Academic Article
Structure based prediction of subtype-selectivity for adenosine receptor antagonists Academic Article
Structure of REV-ERB beta ligand-binding domain bound to a porphyrin antagonist Academic Article
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator Academic Article
Structure of a thioredoxin-like 2fe-2s ferredoxin from aquifex aeolicus Academic Article
Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster Academic Article
Structure of an MmyB-like regulator from C-aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes Academic Article
Structure of an agonist-bound human A₂A adenosine receptor Academic Article
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate Academic Article
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex Academic Article
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone Academic Article
Structure of the glucagon receptor in complex with a glucagon analogue Academic Article
Structure of the human P2Y(12) receptor in complex with an antithrombotic drug Academic Article
Structure of the human glucagon class B G-protein-coupled receptor Academic Article
Structure of the human histamine h(1) receptor complex with doxepin Academic Article
Structure of the human smoothened receptor bound to an antitumour agent Academic Article
Structure of the intact ppar-gamma-rxr-alpha nuclear receptor complex on DNA Academic Article
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic Academic Article
Structure-activity relationships in the binding of chemically derivatized cd4 to gp120 from human immunodeficiency virus Academic Article
Structure-activity relationships through sequencing (stARTS) defines optimal and suboptimal RNA motif targets for small molecules Academic Article
Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors Academic Article
Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists Academic Article
Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors Academic Article
Structure-based stabilization of hiv-1 gp120 enhances humoral immune responses to the induced co-receptor binding site Academic Article
Structure-based virtual screening and biological evaluation of Mycobacterium tuberculosis adenosine 5'-phosphosulfate reductase inhibitors Academic Article
Structure-function of the G protein-coupled receptor superfamily Academic Article
Structure-function-folding relationship in a WW domain Academic Article
Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains Academic Article
Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists Academic Article
Structure/function studies on a S-adenosyl-(L)-methionine-dependent uroporphyrinogen III C methyltransferase (SUMT), a key regulatory enzyme of tetrapyrrole biosynthesis Academic Article
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations Academic Article
Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: Heme activation via reduction-gated exogenous ligand exchange Academic Article
Studies on reconstitution of bovine erythrocyte superoxide dismutase .4. Preparation and some properties of enzyme in which co(ii) is substituted for zn(ii) Academic Article
Studies on the mechanism of oxidative-phosphorylation - effects of specific f-0 modifiers on ligand-induced conformation changes of f1 Academic Article
Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption Academic Article
Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal Academic Article
Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase Academic Article
Substrate-ligand interactions in Geobacillus stearothermophilus nitric oxide synthase Academic Article
Successful strategies to determine high-resolution structures of GPCRs Academic Article
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Sweet spots in functional glycomics Academic Article
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Synthesis and activity of ruthenium alkylidene complexes coordinated with phosphine and N-heterocyclic carbene ligands Academic Article
Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies Academic Article
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors Academic Article
Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2 Academic Article
Synthesis and characterization of cerium and yttrium alkoxide complexes supported by ferrocene-based chelating ligands Academic Article
Synthesis and evaluation of novel pyridine based PLG tripeptidomimetics Academic Article
Synthesis and evaluation of vancomycin aglycon analogues that bear modifications in the N-terminal D-leucyl amino acid Academic Article
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Synthesis of a three zinc finger protein, Zif268, by native chemical ligation Academic Article
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Synthetic receptors with antibody-like binding affinities Academic Article
Synthetic small molecules that control stem cell fate Academic Article
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The brain galanin receptors: targets for novel antidepressant drugs Academic Article
The coactivator lxxll nuclear receptor recognition motif Academic Article
The contactin-related protein FAR-2 defines Purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum Academic Article
The crystal structure of avian cd1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian cd1 Academic Article
The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism Academic Article
The discovery of 3-(n-alkyl)aminopropylphosphonic acids as potent s1p receptor agonists Academic Article
The dynamic energy landscape of dihydrofolate reductase catalysis Academic Article
The dynamics of ligand-receptor interactions. Real-time analyses of association, dissociation, and internalization of an N-formyl peptide and its receptors on the human neutrophil Academic Article
The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor Academic Article
The genesis of high-throughput structure-based drug discovery using protein crystallography Academic Article
The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand Academic Article
The importance of hydrophobic interactions in the antagonist binding to the muscarinic acetylcholine receptor Academic Article
The importance of ligand-receptor conformational pairs in stabilization: spotlight on the N/OFQ G protein-coupled receptor Academic Article
The importance of ligands for G protein-coupled receptor stability Academic Article
The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin Academic Article
The interleukin-1 system: Receptors, ligands, and ICE in the brain and their involvement in the fever response Academic Article
The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gamma delta T cell activation Academic Article
The leptin receptor system of human platelets Academic Article
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry Academic Article
The mechanism of molecular redundancy in autoimmune inflammation in the context of CD44 deficiency Academic Article
The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins Academic Article
The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K Academic Article
The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor Academic Article
The nerve growth factor/tumor necrosis factor receptor family Academic Article
The nuclear receptor lxr is a glucose sensor Academic Article
The pharmacology of lxr Academic Article
The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster Academic Article
The privileged chemical space predictor (PCSP): A computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries Academic Article
The quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution Academic Article
The role of chelating diamine ligands in the goldberg reaction: a kinetic study on the copper-catalyzed amidation of aryl iodides Academic Article
The role of dynamic conformational ensembles in biomolecular recognition Academic Article
The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies Academic Article
The role of platelet adhesion receptor GPIb alpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis Academic Article
The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo Academic Article
The specificity of tcr/pmhc interaction Academic Article
The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae Academic Article
The structure, organization, activation and plasticity of the erythropoietin receptor Academic Article
The synthesis and in vivo evaluation of F-18 PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH) Academic Article
The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs Academic Article
The tryptophan-derived ndogenous aryl hydrocarbon receptor ligand 6-formylindolo 3,2-b carbazole Is a nanomolar UVA photosensitizer in epidermal keratinocytes Academic Article
The type I interleukin-1 receptor mediates fever in the rat as shown by interleukin-1 receptor subtype selective ligands Academic Article
The type iii effector espf coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways Academic Article
The use of carbohydrate microarrays to study carbohydrate-cell interactions and to detect pathogens Academic Article
Themis sets the signal threshold for positive and negative selection in T-cell development Academic Article
Therapeutics targeting the innate immune system Academic Article
Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules Academic Article
Thiophene-core estrogen receptor ligands having superagonist activity Academic Article
Three-dimensional EM structure of the ectodomain of integrin alpha V beta 3 in a complex with fibronectin Academic Article
Three-dimensional structure of the ephb2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition Academic Article
Thymic selection by a single mhc/peptide ligand produces a semidiverse repertoire of cd4(+) t cells Academic Article
Thymic selection by a single mhc/peptide ligand: Autoreactive t cells are low-affinity cells Academic Article
Thymic selection threshold defined by compartmentalization of ras/mapk signalling Academic Article
Thymocyte expression of cathepsin L is essential for NKT cell development Academic Article
Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands Academic Article
Tight association of the human mel(1a)-melatonin receptor and g(i): Precoupling and constitutive activity Academic Article
Tissue factor signaling Academic Article
Tissue- and epitope-specific mechanisms account for the diverse effects of anti-CD44 antibodies on the maintenance of primitive hematopoietic progenitors in vitro Academic Article
Tlr4/md-2 monoclonal antibody therapy affords protection in experimental models of septic shock Academic Article
Toll-like receptor signaling inhibits hepatitis B virus replication in vivo Academic Article
Toll-like receptors in atherosclerosis Academic Article
Topographical distribution of redox centers and the q(o) site in ubiquinol-cytochrome-c oxidoreductase (complex-iii) and ligand structure of the rieske iron-sulfur cluster Academic Article
Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta(3) subunit Academic Article
Toward a rational design of peptide inhibitors of ribonucleotide reductase: structure-function and modeling studies Academic Article
Transduction of dendritic cells with Bcl-xL increases their resistance to prostate cancer-induced apoptosis and antitumor effect in mice Academic Article
Transformation of low-affinity lead compounds into high-affinity protein capture agents Academic Article
Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation Academic Article
Treatment with lxr agonists after focal cerebral ischemia prevents brain damage Academic Article
Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor Academic Article
Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures Academic Article
Tryptophan-accelerated electron flow through proteins Academic Article
Tumor regression by targeted gene delivery to the neovasculature Academic Article
Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (h-nox) domain Academic Article
Turning G proteins on and off using peptide ligands Academic Article
Two antigenically related neuronal cell adhesion molecules of different specificities mediate neuron-neuron and neuron-glia adhesion Academic Article
Two independent sets of monoclonal antibodies define neoepitopes linked to soluble ligand binding and leukocyte adhesion functions of activated alpha(M)beta(2) Academic Article
Two ligands may bind simultaneously to the muscarine receptor Academic Article
Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa Academic Article
Two-dimensional IR spectroscopy of protein dynamics using two vibrational labels: a site-specific genetically encoded unnatural amino acid and an active site ligand Academic Article
Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactions Academic Article
Two-dimensional combinatorial screening identifies specific 6 '-acylated kanamycin A- and 6 '-acylated neamine-RNA hairpin interactions Academic Article
Two-dimensional combinatorial screening identifies specific aminoglycoside - RNA internal loop partners Academic Article
UV and sunlight driven photoligation of quantum dots: understanding the photochemical transformation of the ligands Academic Article
Underscoring the influence of inorganic chemistry on nuclear imaging with radiometals Academic Article
Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase Academic Article
Unique ability of integrin alpha(v)beta(3) to support tumor cell arrest under dynamic flow conditions Academic Article
Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange Academic Article
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops Academic Article
Unlocking nature's C-H bonds Academic Article
Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease iv Academic Article
Unusual arginine formations in protein function and assembly: Rings, strings, and stacks Academic Article
Uranyl ion coordination with rigid aromatic carboxylates and structural characterization of their complexes Academic Article
Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior Academic Article
Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling Academic Article
Use of phage display and transition-state analogs to select enzyme variants with altered catalytic properties: Glutathione transferase as an example Academic Article
Using AutoDock for ligand-receptor docking Academic Article
Using modularly assembled ligands to bind RNA internal loops separated by different distances Academic Article
Utility of redundant combinatorial libraries in distinguishing high and low quality screening hits Academic Article
Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention Academic Article
Vanadium-catalyzed asymmetric epoxidation of allylic alcohols in water Academic Article
Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue, and West Nile viruses Academic Article
Virtual screening for HIV protease inhibitors: a comparison of AutoDock 4 and Vina Academic Article
Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors Academic Article
Virtual screening of integrase inhibitors by large scale binding free energy calculations: the SAMPL4 challenge Academic Article
Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challenge Academic Article
What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands? Academic Article
When does chemical elaboration induce a ligand to change its binding mode? Academic Article
X-ray structures of the LXRα LBD in its homodimeric form and implications for heterodimer signaling Academic Article
cDNA sequence, ligand biding, and regulation of galanin/GMAP in mouse brain Academic Article
αβ T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization Academic Article

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