subject area of
- 1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams Academic Article
- A small molecule that directs differentiation of human ESCs into the pancreatic lineage Academic Article
- An alkoxide-directed intermolecular 2+2+1 annulation: A three-component coupling reaction for the synthesis of tetrasubstituted alpha,beta,-unsaturated gamma-lactams Academic Article
- Bifunctional acyltransferase/decarboxylase lnmk as the missing link for beta-alkylation in polyketide biosynthesis Academic Article
- C-S bond cleavage by a polyketide synthase domain Academic Article
- Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from streptomyces atroolivaceus s-140 - discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load d-alanine Academic Article
- Characterization of the inmklm genes unveiling key intermediates for beta-alkylation in leinamycin biosynthesis Academic Article
- Clefts as receptor and enzyme analogues Academic Article
- Complex polycyclic lactams from pericyclic cascade reactions of Zincke aldehydes Academic Article
- Construction of highly functional α-amino nitriles via a novel multicomponent tandem organocatalytic reaction: a facile access to α-methylene γ-lactams Academic Article
- Convergent synthesis of stereodefined exo-alkylidene-gamma-lactams from beta-halo allylic alcohols Academic Article
- Enantioselective TADMAP-catalyzed carboxyl migration reactions for the synthesis of stereogenic quaternary carbon Academic Article
- Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in streptomyces atroolivaceus s-140 Academic Article
- Identification of novel macrocyclic peptidase substrates via on-bead enzymatic cyclization Academic Article
- Iodine(V) reagents in organic synthesis. Part 3. New routes to heterocyclic compounds via o-iodoxybenzoic acid-mediated cyclizations: Generality, scope, and mechanism Academic Article
- Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species Academic Article
- Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase Academic Article
- Macrolactamization of glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase Academic Article
- N-(phenylthio)-epsilon-caprolactam: A new promoter for the activation of thioglycosides Academic Article
- One-pot synthesis of lactams using domino reactions: combination of Schmidt reaction with Sakurai and aldol reactions Academic Article
- Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in streptomyces atroolivaceus s-140 Academic Article
- Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic Academic Article
- Stereoselective synthesis of the disaccharide unit of incednine Academic Article
- Structure of the bifunctional acyltransferase/decarboxylase lnmk from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold Academic Article
- Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors Academic Article
- Synthesis and evaluation of 8,4 '-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin Academic Article
- Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin Academic Article
- Synthesis of β-, γ-, and δ-Lactams via Pd(II)-catalyzed C−H activation reaction Academic Article
- The direct organocatalytic asymmetric mannich reaction: Unmodified aldehydes as nucleophiles Academic Article
- Type i polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis Academic Article
- γ,δ,ε-C(sp(3))-H functionalization through directed radical H-abstraction Academic Article