subject area of

• (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium  Academic Article
• 2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one Derivatives as Potent and Selective Histamine-3 Receptor Antagonists  Academic Article
• A cyclic nucleotide-dependent chloride conductance in olfactory receptor neurons  Academic Article
• A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from streptomyces griseus  Academic Article
• A new regulatory switch in a JAK protein kinase  Academic Article
• A quantitative analysis of connexin-specific permeability differences of gap junctions expressed in HeLa transfectants and Xenopus oocytes  Academic Article
• A semi-synthetic organism with an expanded genetic alphabet  Academic Article
• Action of norepinephrine in rat hippocampus .2. Activation of input pathway  Academic Article
• An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription  Academic Article
• Basic FGF increases communication between cells of the developing neocortex  Academic Article
• Characterization of T-5 N-oxide formation as the first highly selective measure of CYP3A5 activity  Academic Article
• Characterization of fdmv as an amide synthetase for fredericamycin a biosynthesis in streptomyces griseus atcc 43944  Academic Article
• Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from streptomyces griseus  Academic Article
• Cortistatin a is a high-affinity ligand of protein kinases rock, cdk8, and cdk11  Academic Article
• Derivatives of 4-amino-3,6-disulfonato-1,8-naphthalimide inhibit reverse-transcriptase and suppress human and feline immunodeficiency virus expression in cultured-cells  Academic Article
• Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors  Academic Article
• Didehydro-Cortistatin A: a new player in HIV-therapy?  Academic Article
• Didehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic mice  Academic Article
• Discovery of a novel class of negative allosteric modulator of the dopamine D-2 receptor through fragmentation of a bitopic ligand  Academic Article
• Discovery of clinical candidate 1-{ (2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl methoxy}-7-methoxyi soquinoline-6-carboxamide (PF-06650833), a potent, selective inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4), by fragment -based drug design  Academic Article
• Efficient synthesis of dimeric oxazoles, piperidines and tetrahydroisoquinolines from N-substituted 2-oxazolones  Academic Article
• Ethanol and some tetrahydroisoquinolines alter the discharge of cortical and hippocampal-neurons - relationship to endogenous opioids  Academic Article
• Hit-to-lead studies for the antimalarial tetrahydroisoquinolone carboxanilides  Academic Article
• Identification and utility of fdmr1 as a streptomyces antibiotic regulatory protein activator for fredericamycin production in streptomyces griseus atcc 49344 and heterologous hosts  Academic Article
• Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB  Academic Article
• Identification of fredericamycin e from streptomyces griseus: Insights into fredericamycin a biosynthesis highlighting carbaspirocycle formation  Academic Article
• In vivo investigation of the roles of fdmm and fdmm1 in fredericamycin biosynthesis unveiling a new family of oxygenases  Academic Article
• Inhibition of purkinje cells in the frog cerebellum. Ii. Evidence for gaba as the inhibitory transmitter  Academic Article
• Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydrolsoquinoline lead series  Academic Article
• Interaction between serotonin transporter and dopamine D2/D3 receptor radioligand measures is associated with harm avoidant symptoms in anorexia and bulimia nervosa  Academic Article
• Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters  Academic Article
• Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus  Academic Article
• Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells  Academic Article
• Kinase signaling initiates coat complex II (COPII) recruitment and export from the mammalian endoplasmic reticulum  Academic Article
• Metabolism of h-3 dopamine following intracerebroventricular injection in rats pretreated with ethanol or chloral hydrate  Academic Article
• Modulation of human DNA methyltransferase activity and messenger-rna levels in the monoblast cell-line u937 induced to differentiate with dibutyryl-cyclic-amp and phorbol ester  Academic Article
• N-Isoquinolin-5-yl-N '-aralkyl-urea and -amide antagonists of human vanilloid receptor 1  Academic Article
• N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: Modulators of human vanilloid receptor 1 (TRPV1)  Academic Article
• New reactions of IBX: Oxidation of nitrogen- and sulfur-containing substrates to afford useful synthetic intermediates  Academic Article
• Nmda receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: Role of the ventral tegmental area and central nucleus of the amygdala  Academic Article
• Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening  Academic Article
• Renal functional reserve in experimental chronic glomerulonephritis  Academic Article
• Rho kinase (ROCK) inhibitors and their application to inflammatory disorders  Academic Article
• Somatostatin immunohistochemistry of hippocampal slices with lucifer yellow-stained pyramidal neurons responding to somatostatin  Academic Article
• Stereodivergent synthesis of 17-alpha and 17-beta-alpharyl steroids: Application and biological evaluation of D-ring cortistatin analogues  Academic Article
• Synthesis and SAR of tetrahydroisoquinolines as Rev-erb alpha agonists  Academic Article
• Synthesis of (+)-pancratistatins via catalytic desymmetrization of benzene  Academic Article
• Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors  Academic Article
• The E-2.65 A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors  Academic Article
• The Tat inhibitor didehydro-Cortistatin A prevents HIV-1 reactivation from latency  Academic Article
• The Tat inhibitor didehydro-cortistatin a prevents HIV-1 reactivation from latency  Academic Article
• The cell cycle-dependent nuclear import of v-jun is regulated by phosphorylation of a serine adjacent to the nuclear localization signal  Academic Article
• The differential influence of protein-kinase inhibitors on retinal arbor morphology and eye-specific stripes in the frog retinotectal system  Academic Article
• The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo  Academic Article
• The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells  Academic Article
• Total synthesis and biological evaluation of cortistatins a and j and analogues thereof  Academic Article
• Total synthesis of (+)-cortistatin a  Academic Article
• Universal bases for hybridization, replication and chain termination  Academic Article