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Sleep Initiation and Maintenance Disorders

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  • Association between nocturnal vagal tone and sleep depth, sleep quality, and fatigue in alcohol dependence  Academic Article
  • Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia  Academic Article
  • Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia  Academic Article
  • Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements  Academic Article
  • Discovery of dual orexin receptor antagonists (DORAs) for the treatment of insomnia  Academic Article
  • Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis  Academic Article
  • Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia  Academic Article
  • EEG spectral analysis in primary insomnia: NREM period effects and sex differences  Academic Article
  • Gabapentin for the treatment of alcohol use disorder  Academic Article
  • Measuring sleep disturbances in patients with alcohol use disorders: a short questionnaire suitable for routine practice  Academic Article
  • Orexin receptor antagonists: medicinal chemistry and therapeutic potential  Academic Article
  • Orexin receptor antagonists: new therapeutic agents for the treatment of insomnia  Academic Article
  • Ritanserin in the treatment of alcohol dependence: a multi-center clinical trial  Academic Article
  • SLEEPLESS-ness and insomnia in fruit flies  Academic Article
  • The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine  Academic Article
  • The neurobiology, clinical efficacy and safety of acamprosate in the treatment of alcohol dependence  Academic Article

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