subject area of

• "Don't know much bile-ology"  Academic Article
• "Resistance" to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 do not confer resistance  Academic Article
• "Viral deja vu" elicits organ-specific immune disease independent of reactivity to self  Academic Article
• 'Late onset' ornithine transcarbamylase deficiency: function of three purified recombinant mutant enzymes  Academic Article
• 'Muscle-sparing' statins: preclinical profiles and future clinical use  Academic Article
• 'Reverse' alpha-ketoamide-based p38 map kinase inhibitors  Academic Article
• 'SNO'-storms compromise protein activity and mitochondrial metabolism in neurodegenerative disorders  Academic Article
• 'Translocatory proteins' and 'protein transduction domains': A critical analysis of their biological effects and the underlying mechanisms  Academic Article
• (18)F Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey  Academic Article
• (18)F-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of beta-amyloid fibrils  Academic Article
• (4,2)D projection-reconstruction experiments for protein backbone assignment: application to human carbonic anhydrase II and calbindin D(28K)  Academic Article
• -Amino acid substitution of peptide-mediated NF-κB suppression in mdx mice preserves therapeutic benefit in skeletal muscle, but causes kidney toxicity  Academic Article
• 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia  Academic Article
• 1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo 4,3-d pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors  Academic Article
• 1-(2-Ethoxyethyl)-1H-pyrazolo 4,3-d pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors  Academic Article
• 1-H NMR detection of small molecules in human urine with a deep cavitand synthetic receptor  Academic Article
• 1-deamino-8-D-arginine vasopressin and cryoprecipitate in variant von Willebrand disease  Academic Article
• 1-deamino-8-D-arginine vasopressin: a new pharmacological approach to the management of haemophilia and von Willebrands' diseases  Academic Article
• 1-year survival in a randomized trial of facilitated reperfusion results from the finesse (facilitated intervention with enhanced reperfusion speed to stop events) trial  Academic Article
• 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase  Academic Article
• 10-formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway  Academic Article
• 10-formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase  Academic Article
• 100 cemented versus 100 noncemented stems with comparison of 25 matched pairs  Academic Article
• 13C NMR studies of the product complex of glyoxalase I  Academic Article
• 14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination  Academic Article
• 14-3-3 proteins in neuronal development and function  Academic Article
• 1H, 13C and 15N chemical shift assignments for the human Pitx2 homeodomain and a R24H homeodomain mutant  Academic Article
• 2 cases of agammaglobulinemia detected by determining the blood group [Article in Russian]  Academic Article
• 2-(3,5-dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor  Academic Article
• 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor  Academic Article
• 2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one Derivatives as Potent and Selective Histamine-3 Receptor Antagonists  Academic Article
• 2-Amino- 1,2,4 triazolo 1,5-a pyridines as JAK2 inhibitors  Academic Article
• 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport  Academic Article
• 2-Aminobenzimidazoles as potent Aurora kinase inhibitors  Academic Article
• 2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis  Academic Article
• 2-Bromopalmitate analogues as activity-based probes to explore palmitoyl acyltransferases  Academic Article
• 2-Chlorodeoxyadenosine activity in patients with untreated, indolent non-Hodgkin's lymphoma  Academic Article
• 2-Propylthiouracil does not replace glutathione for the glutathione transferases  Academic Article
• 2-chlorodeoxyadenosine in the treatment of chronic refractory immune thrombocytopenic purpura  Academic Article
• 2-microglobulin: a free immunoglobulin domain  Academic Article
• 2-year outcome after angiographically documented myocardial reperfusion for acute coronary-occlusion  Academic Article
• 2010 white paper on recent issues in regulated bioanalysis & global harmonization of bioanalytical guidance  Academic Article
• 24 hours in the life of HIV-1 in a T cell line  Academic Article
• 28th Bethesda Conference. Task force 5: Assessment, approval, and regulation of new technology  Academic Article
• 384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids  Academic Article
• 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)pi perazine-1-carbothioamide (ML267), a Potent Inhibitor of Bacterial Phosphopantetheinyl Transferase That Attenuates Secondary Metabolism and Thwarts Bacterial Growth  Academic Article
• 4-Aminoindazolyl-dihydrofuro 3,4-d pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase  Academic Article
• 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency  Academic Article
• 4-Methyl-6,7-dihydro-4H-triazolo 4,5-c pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate  Academic Article
• 4-O-acetyl-N-acetylneuraminic acid in the N-linked carbohydrate structures of equine and guinea pig alpha 2-macroglobulins, potent inhibitors of influenza virus infection  Academic Article
• 4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms  Academic Article
• 5 alpha-Androstan-3 alpha,17 beta-diol is a hormone: stimulation of cAMP accumulation in human and dog prostate  Academic Article
• 5-HT(2C) agonists as therapeutics for the treatment of schizophrenia  Academic Article
• 5-ht(1a) receptor binding is increased after recovery from bulimia nervosa compared to control women and is associated with behavioral inhibition in both groups  Academic Article
• 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103)  Academic Article
• 50 Years of structural immunology  Academic Article
• 68Ga-PSMA-11 PET imaging of response to androgen receptor inhibition: first human experience  Academic Article
• 7-Hydroxynaphthalen-1-yl-urea and -amide antagonists of human vanilloid receptor 1  Academic Article
• 7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase  Academic Article
• 8-Hydroxyquinoline and hydroxamic acid inhibitors of botulinum neurotoxin BoNT/A  Academic Article
• 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors  Academic Article
• 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response  Academic Article
• A "flip-flop" rotation stage for routine dual-axis electron cryotomography  Academic Article
• A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity  Academic Article
• A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2  Academic Article
• A 3-dimensional extracellular matrix as a delivery system for the transplantation of glioma-targeting neural stem/progenitor cells  Academic Article
• A 46-nucleotide promoter segment from an IFN-alpha gene renders an unrelated promoter inducible by virus  Academic Article
• A 50-kDa membrane protein mediates sialic acid-independent binding and infection of conjunctival cells by adenovirus type 37  Academic Article
• A 52-kD protein is a novel component of the SS-A/Ro antigenic particle  Academic Article
• A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity  Academic Article
• A Bellagio consensus. Children's Vaccine Initiative Ad Hoc Committe on an investment strategy for measles control  Academic Article
• A Bifunctional NAD(+) for Profiling Poly-ADP-Ribosylation-Dependent Interacting Proteins  Academic Article
• A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines  Academic Article
• A Clinical Indications Prediction Scale Based on TWIST1 for Human Mesenchymal Stem Cells  Academic Article
• A Comprehensive Explanation Framework for Biomedical Time Series Classification  Academic Article
• A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response  Academic Article
• A DNA vaccine for ebola virus is safe and immunogenic in a phase i clinical trial  Academic Article
• A Fc engineering approach to define functional humoral correlates of immunity against Ebola virus  Academic Article
• A GTP affinity probe for proteomics highlights flexibility in purine nucleotide selectivity  Academic Article
• A HaloTag-based multicolor fluorogenic sensor visualizes and quantifies proteome stress in live cells using solvatochromic and molecular rotor-based fluorophores  Academic Article
• A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids  Academic Article
• A New World primate deficient in tetherin-mediated restriction of human immunodeficiency virus type 1  Academic Article
• A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis  Academic Article
• A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate  Academic Article
• A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling  Academic Article
• A SNAP-tag fluorogenic probe mimicking the chromophore of the red fluorescent protein Kaede  Academic Article
• A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice  Academic Article
• A THEMIS:SHP1 complex promotes T-cell survival  Academic Article
• A TRP channel that senses cold stimuli and menthol  Academic Article
• A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model  Academic Article
• A Useful Combination of Quantitative Ultrashort Echo Time MR Imaging and a Probing Device for Biomechanical Evaluation of Articular Cartilage  Academic Article
• A Yersinia-pseudotuberculosis protein which cross-reacts with HLA-B27  Academic Article
• A bifunctional molecule that displays context-dependent cellular activity  Academic Article
• A binary plasmid system for shuffling combinatorial antibody libraries  Academic Article
• A biochemically distinct sub-population of neurons in the human substantia gelatinosa. Study with G-6-PD histochemistry  Academic Article
• A bioinformatic assay for pluripotency in human cells  Academic Article
• A biomechanical evaluation of three surgical techniques for subscapularis repair  Academic Article
• A biomechanical study of the aponeurotic inguinal hernia repair  Academic Article
• A biosynthetic approach for the incorporation of unnatural amino acids into proteins  Academic Article
• A biparatopic HER2-targeting antibody-drug conjugate induces tumor regression in primary models refractory to or ineligible for HER2-targeted therapy  Academic Article
• A bleeding disorder due to deficiency of alpha-2-antiplasmin  Academic Article
• A blood based 12-miRNA signature of Alzheimer disease patients  Academic Article
• A blueprint for HIV vaccine discovery  Academic Article
• A brave new MYC-amplified world  Academic Article
• A brief review of the past and future of platelet P2Y12 antagonist  Academic Article
• A broadly neutralizing human monoclonal antibody exhibits in vivo efficacy against both human metapneumovirus and respiratory syncytial virus  Academic Article
• A c-alpha model for the transmembrane alpha helices of gap junction intercellular channels  Academic Article
• A call for action on primary care and public health integration  Academic Article
• A camera-phone based study reveals erratic eating pattern and disrupted daily eating-fasting cycle among adults in India  Academic Article
• A candidate circuit approach to investigating autism  Academic Article
• A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase  Academic Article
• A candidate live inactivatable attenuated vaccine for aids  Academic Article
• A carbohydrate-conjugated deep cavitand permits observation of caviplexes in human serum  Academic Article
• A carbohydrate-derived splice modulator  Academic Article
• A case of an entrapped rotational atherectomy burr  Academic Article
• A case study on forensic polymer analysis by dios-ms: The suspect who gave us the slip (r)  Academic Article
• A catechol-O-methyltransferase that is essential for auditory function in mice and humans  Academic Article
• A cd4+ cytotoxic lymphocyte-t clone to a conserved epitope on human-immunodeficiency-virus type-1 p24 - cytotoxic activity and secretion of interleukin-2 and interleukin-6  Academic Article
• A cdc6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor  Academic Article
• A cell-based luciferase assay amenable to high-throughput screening of inhibitors of arenavirus budding  Academic Article
• A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells  Academic Article
• A cell-cycle-regulated inhibitor of cyclin-dependent kinases  Academic Article
• A cell-free expression and purification process for rapid production of protein biologics  Academic Article
• A cell-penetrating peptide from a novel pVII-pIX phage-displayed random peptide library  Academic Article
• A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy  Academic Article
• A cell-permeable synthetic transcription factor mimic  Academic Article
• A cellular gene encodes scrapie prp 27-30 protein  Academic Article
• A central strategy for converting natural products into fluorescent probes  Academic Article
• A change in the conformation of prions accompanies the emergence of a new prion strain  Academic Article
• A chaperone trap contributes to the onset of cystic fibrosis  Academic Article
• A chemical approach for detecting sulfenic acid-modified proteins in living cells  Academic Article
• A chemical approach for the detection of protein sulfinylation  Academic Article
• A chemical approach to stem cell biology  Academic Article
• A chemical approach to stem-cell biology and regenerative medicine  Academic Article
• A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β  Academic Article
• A chemical chaperone decouples TDP-43 disordered domain phase separation from fibrillation  Academic Article
• A chemical genomic analysis of decoquinate, a plasmodium falciparum cytochrome b inhibitor  Academic Article
• A chemical platform for improved induction of human iPSCs  Academic Article
• A chemical switch for inhibitor-sensitive alleles of any protein kinase  Academic Article
• A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (ppar alpha) versus liver x receptor  Academic Article
• A chemical, genetic, and structural analysis of the nuclear bile acid receptor fxr  Academic Article
• A chemically functionalized magnetic nanoplatform for rapid and specific biomolecular recognition and separation  Academic Article
• A chemically induced vaccine strategy for prostate cancer  Academic Article
• A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase  Academic Article
• A chemically stable fluorescent marker of the ureter  Academic Article
• A chemo-enzymatic approach to the study of carbohydrate recognition in biological systems  Academic Article
• A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles  Academic Article
• A child with fever after hematopoietic stem cell transplantation  Academic Article
• A chimeric hiv-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (gm-csf) domain induces enhanced antibody and t cell responses  Academic Article
• A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: Design, synthesis, and in vitro and in vivo evaluation  Academic Article
• A chromatin binding-site in the tail domain of nuclear lamins that interacts with core histones  Academic Article
• A circulating, disease-specific, mechanism-linked biomarker for ATTR polyneuropathy diagnosis and response to therapy prediction  Academic Article
• A clinical study of an unusual case of asthma associated with urticaria pigmentosa  Academic Article
• A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction  Academic Article
• A coactivator trap identifies NONO (p54(nrb)) as a component of the cAMP-signaling pathway  Academic Article
• A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway  Academic Article
• A colorectal cancer classification system that associates cellular phenotype and responses to therapy  Academic Article
• A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection  Academic Article
• A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors  Academic Article
• A combination of low-dose cyclophosphamide and colony-stimulating factors is more cost-effective than granulocyte-colony-stimulating factors alone in mobilizing peripheral blood stem and progenitor cells  Academic Article
• A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1  Academic Article
• A combined chemical and genetic approach for the generation of induced pluripotent stem cells  Academic Article
• A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay  Academic Article
• A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations  Academic Article
• A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to Legionnaires' disease  Academic Article
• A common genetic polymorphism (46 C to T substitution) in the 5 '-untranslated region of the coagulation factor XII gene is associated with low translation efficiency and decrease in plasma factor XII level  Academic Article
• A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells  Academic Article
• A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls  Academic Article
• A common solution to group 2 influenza virus neutralization  Academic Article
• A comparative analysis of HGSC and Celera human genome assemblies and gene sets  Academic Article
• A comparative encyclopedia of DNA elements in the mouse genome  Academic Article
• A comparative immunogenicity study of hiv-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120  Academic Article
• A comparison between activated protein C and des-1-41-light chain-activated protein C in reactions with type 1 plasminogen activator inhibitor  Academic Article
• A comparison of cf and non-cf school-age children undergoing lung transplantation  Academic Article
• A comparison of debulking versus dilatation of bifurcation coronary arterial narrowings (from the caveat i trial)  Academic Article
• A comparison of directional atherectomy with coronary angioplasty in patients with coronary-artery disease  Academic Article
• A comparison of ionic versus nonionic contrast medium during primary percutaneous transluminal coronary angioplasty for acute myocardial infarction (gusto iib)  Academic Article
• A comparison of linear and cyclic peptoid oligomers as potent antimicrobial agents  Academic Article
• A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence  Academic Article
• A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes  Academic Article
• A comparison of reteplase with alteplase for acute myocardial infarction  Academic Article
• A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models  Academic Article
• A comparison of the Celera and Ensembl predicted gene sets reveals little overlap in novel genes  Academic Article
• A comparison of the abilities of plasma kallikrein, beta-Factor XIIa, Factor XIa and urokinase to activate plasminogen  Academic Article
• A comparison of the atomic model of F-actin with cryo-electron micrographs of actin and decorated actin  Academic Article
• A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes  Academic Article
• A comparison of two neurologic scoring instruments for multiple sclerosis  Academic Article
• A compass for stem-cell differentiation  Academic Article
• A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin  Academic Article
• A complex equilibrium among partially unfolded conformations in monomeric transthyretin  Academic Article
• A complex of Protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion  Academic Article
• A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis  Academic Article
• A complexity measure for selective matching of signals by the brain  Academic Article
• A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells  Academic Article
• A computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells  Academic Article
• A concise and flexible synthesis of the potent anti-influenza agents tamiflu and tamiphosphor  Academic Article
• A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies  Academic Article
• A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses  Academic Article
• A conserved "hydrophobic staple motif" plays a crucial role in the refolding of human glutathione transferase P1-1  Academic Article
• A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis  Academic Article
• A conserved family of prolyl-4-hydroxylases that modify HIF  Academic Article
• A conserved hiv gp120 glycoprotein structure involved in chemokine receptor binding  Academic Article
• A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase  Academic Article
• A conserved motif in the itk ph-domain is required for phosphoinositide binding and tcr signaling but dispensable for adaptor protein interactions  Academic Article
• A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function  Academic Article
• A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins  Academic Article
• A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension  Academic Article
• A contemporary assessment of low-molecular-weight heparin for the treatment of acute coronary syndromes: Factoring in new trials and meta-analysis data  Academic Article
• A continuous, spectroscopic analysis of the kinetics of elastase secretion by neutrophils. The dependence of secretion upon receptor occupancy  Academic Article
• A cost-effective fluorescence mini-microscope for biomedical applications  Academic Article
• A credit-card library approach for disrupting protein-protein interactions  Academic Article
• A critical analysis of codon optimization in human therapeutics  Academic Article
• A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. II. Potential for quantitation of antibody content  Academic Article
• A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. III. Comparative performance characteristics of academic and manufacturers' laboratories  Academic Article
• A critical evaluation of enzyme immunoassays for detection of antinuclear autoantibodies of defined specificities. I. Precision, sensitivity, and specificity  Academic Article
• A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells  Academic Article
• A critical role for TORC1 in cellular senescence  Academic Article
• A critical role for monocytes and cd14 in endotoxin-induced endothelial-cell activation  Academic Article
• A critical role for the sphingosine analog aal-r in dampening the cytokine response during influenza virus infection  Academic Article
• A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase  Academic Article
• A cross-neutralizing antibody between HIV-1 and influenza virus  Academic Article
• A cross-over inhibitor of the botulinum neurotoxin light chain B: A natural product implicating an exosite mechanism of action  Academic Article
• A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics  Academic Article
• A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling  Academic Article
• A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy  Academic Article
• A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome  Academic Article
• A curcumin derivative that inhibits vinyl carbamate-induced lung carcinogenesis via activation of the Nrf2 protective response  Academic Article
• A customized self-assembling peptide hydrogel for dental pulp tissue engineering  Academic Article
• A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts  Academic Article
• A decrease in the size of the basal ganglia following prenatal alcohol exposure - a preliminary-report  Academic Article
• A defective V-kappa A2 allele in navajos which play play a role in increased susceptibility to haemophilus influenzae type disease  Academic Article
• A demonstration of the intrinsic importance of stabilizing hydrophobic binding and noncovalent van der Waals contacts dominant in the noncovalent CC-1065/b-DNA binding  Academic Article
• A designed peptidomimetic agonistic ligand of trka nerve growth factor receptors  Academic Article
• A di-acidic (DxE) code directs concentration of cargo during export from the endoplasmic reticulum  Academic Article
• A diffuse infiltrative CD8 lymphocytosis syndrome in human immunodeficiency virus (HIV) infection: a host immune response associated with HLA-DR5  Academic Article
• A direct comparison of tirofiban and abciximab during percutaneous coronary revascularization and stent placement: rationale and design of the TARGET study  Academic Article
• A direct enzymatic assay for the esterolytic activity of activated hageman factor  Academic Article
• A direct, plasmin-independent assay for plasminogen activator  Academic Article
• A discovery strategy for selective inhibitors of c-Src in complex with the focal adhesion kinase SH3/SH2-binding region  Academic Article
• A disease-specific measure of health-related quality of life for use in adults with immune thrombocytopenic purpura: Its development and validation  Academic Article
• A disease-specific measure of health-related quality of life in adults with chronic immune thrombocytopenic purpura: Psychometric testing in an open-label clinical trial  Academic Article
• A distinct reactive oxygen species profile confers chemoresistance in glioma-propagating cells and associates with patient survival outcome  Academic Article
• A distinct slow cellular pathway involving soluble mediators for the t-cell-instructed induction of monocyte tissue factor activity in an allogeneic immune-response  Academic Article
• A dominant-negative peroxisome proliferator-activated receptor gamma (ppar gamma) mutant is a constitutive repressor and inhibits ppar gamma-mediated adipogenesis  Academic Article
• A double monoclonal IgG1k and IgG2k in a single myeloma patient - variation in clonal products and therapeutic responses  Academic Article
• A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral nalmefene HCl for alcohol dependence  Academic Article
• A double-blind, placebo-controlled study of oral nalmefene for alcohol dependence  Academic Article
• A double-blind, placebo-controlled trial of desipramine for primary alcohol dependence stratified on the presence or absence of major depression  Academic Article
• A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis  Academic Article
• A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120  Academic Article
• A double-stranded rna-activated protein kinase-dependent pathway mediating stress-induced apoptosis  Academic Article
• A double-variant transthyretin allele (Ser-6, Ile-33) in the israeli patient SKO with familial amyloidotic polyneuropathy  Academic Article
• A downstream kinase of the mammalian target of rapamycin, p70s6k1, regulates human double minute 2 protein phosphorylation and stability  Academic Article
• A drosophila g(1)-specific cyclin e homolog exhibits different modes of expression during embryogenesis  Academic Article
• A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins  Academic Article
• A dual color immunohistochemistry assay for measurement of cereblon in multiple myeloma patient samples  Academic Article
• A dynamic model of HIV integrase inhibition and drug resistance  Academic Article
• A dynamic search process underlies microRNA targeting  Academic Article
• A dynamin mutant defines a superconstricted prefission state  Academic Article
• A dystroglycan mutation associated with limb-girdle muscular dystrophy  Academic Article
• A facile system for encoding unnatural amino acids in mammalian cells  Academic Article
• A factor IX-deficient mouse model for hemophilia B gene therapy  Academic Article
• A family of cyclin homologs that control the g1 phase in yeast  Academic Article
• A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol)  Academic Article
• A family of lipopolysaccharide binding-proteins involved in responses to gram-negative sepsis  Academic Article
• A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange  Academic Article
• A feasibility study showing [68Ga]citrate PET detects prostate cancer  Academic Article
• A fibroblast growth factor binding protein in human cerebral spinal fluid  Academic Article
• A five-amino-acid motif in the undefined region of the tlr8 ectodomain is required for species-specific ligand recognition  Academic Article
• A fluopol-ABPP HTS assay to identify PAD inhibitors  Academic Article
• A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme a production  Academic Article
• A fluorescent plate reader assay for ceramide kinase  Academic Article
• A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans  Academic Article
• A fluorometric assay for red-blood-cell antibodies  Academic Article
• A focused microarray approach to functional glycomics: Transcriptional regulation of the glycome  Academic Article
• A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function  Academic Article
• A fragment of human TrpRS as a potent antagonist of ocular angiogenesis  Academic Article
• A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia-coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases  Academic Article
• A functional genomics approach to the mode of action of apratoxin A  Academic Article
• A functional genomics strategy reveals Rora as a component of the mammalian circadian clock  Academic Article
• A functional interaction between RIP140 and PGC-1 alpha regulates the expression of the lipid droplet protein CIDEA  Academic Article
• A gdp-bound form of rab1 inhibits protein export from the endoplasmic-reticulum and transport between golgi compartments  Academic Article
• A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the personalized risk evaluation and diagnosis in the coronary tree (predict) trial  Academic Article
• A gene atlas of the mouse and human protein-encoding transcriptomes  Academic Article
• A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells  Academic Article
• A gene expression phenotype in lymphocytes from Friedreich ataxia patients  Academic Article
• A gene expression profile of alzheimer's disease  Academic Article
• A gene expression profile of embryonic stem cells and embryonic stem cell-derived neurons  Academic Article
• A gene for hirschsprung disease (megacolon) in the pericentromeric region of human chromosome-10  Academic Article
• A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation  Academic Article
• A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly  Academic Article
• A general approach to site-specific antibody drug conjugates  Academic Article
• A general fragment-based approach to identify and optimize bioactive ligands targeting RNA  Academic Article
• A general method for insertion of functional proteins within proteins via combinatorial selection of permissive junctions  Academic Article
• A general method to quantify quasi-equivalence in icosahedral viruses  Academic Article
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• Accelerating next-generation vaccine development for global disease prevention  Academic Article
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• Actions of redox-related congeners of nitric oxide at the NMDA receptor  Academic Article
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• Activated protein C  Academic Article
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• Activated protein C and inflammation in human myocardium after heart surgery  Academic Article
• Activated protein C and ischemic stroke  Academic Article
• Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects  Academic Article
• Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo  Academic Article
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• Activated protein C reduces graft neutrophil activation in clinical renal transplantation  Academic Article
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• Activated protein C resistance in ischemic stroke not due to factor V arginine(506)->glutamine mutation  Academic Article
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• Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V  Academic Article
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• Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements  Academic Article
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• Activated protein c-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin  Academic Article
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• Activation and function of gamma-delta t-cells  Academic Article
• Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry  Academic Article
• Activation of CD74 inhibits migration of human mesenchymal stem cells  Academic Article
• Activation of Hageman factor by proteases released during antigen challenge of human lung  Academic Article
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• Activation of angiogenic signaling pathways by two human tRNA synthetases  Academic Article
• Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete c-terminal domain  Academic Article
• Activation of c1 by monoclonal-antibodies directed against c1q  Academic Article
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• Activation of coagulation and angiogenesis in cancer - immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer  Academic Article
• Activation of cyclin e/cdk2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin e  Academic Article
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• Activation of mitogen-activated protein kinases and p90 ribosomal s6 kinase in failing human hearts with dilated cardiomyopathy  Academic Article
• Activation of neutrophils by N-formyl chemotactic peptides  Academic Article
• Activation of nuclear receptor coactivator PGC-1 alpha by arginine methylation  Academic Article
• Activation of p38 in stimulated human neutrophils: Phosphorylation of the oxidase component p47(phox) by p38 and erk but not by jnk  Academic Article
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• Activation of proMMP-9 by a plasmin/MMP-3 cascade in a tumor cell model. Regulation by tissue inhibitors of metalloproteinases  Academic Article
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• Activation of protein C during reperfusion in clinical liver transplantation  Academic Article
• Activation of rabbit tlr9 by different cpg-odn optimized for mouse and human tlr9  Academic Article
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• Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2  Academic Article
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• Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer  Academic Article
• Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats  Academic Article
• Activation of the alternative complement pathway by ebv and the viral envelope glycoprotein, gp350  Academic Article
• Activation of the alternative complement pathway in systemic lupus erythematosus  Academic Article
• Activation of the alternative pathway of complement by antiserum to factor B  Academic Article
• Activation of the first component of human-complement, c1, by monoclonal-antibodies directed against different domains of subcomponent c1q  Academic Article
• Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation  Academic Article
• Activation of tumor cell integrin alpha(v)beta(3) controls angiogenesis and metastatic growth in the brain  Academic Article
• Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth  Academic Article
• Activation of urinary kallikrein in patients with interstitial cystitis  Academic Article
• Activation-independent platelet adhesion and aggregation under elevated shear stress  Academic Article
• Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins  Academic Article
• Activators of the nuclear receptor ppar gamma enhance colon polyp formation  Academic Article
• Active and alkylated human agt structures: A novel zinc site, inhibitor and extrahelical base binding  Academic Article
• Active and inhibited human catalase structures: Ligand and nadph binding and catalytic mechanism  Academic Article
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• Active site modification of factor viia affects interactions of the protease domain with tissue factor  Academic Article
• Active site residues of cyclophilin A are crucial for its signaling activity via CD147  Academic Article
• Active site serine promotes stabilization of the reactive glutathione thiolate in rat glutathione transferase T2-2 - Evidence against proposed sulfatase activity of the corresponding human enzyme  Academic Article
• Active thymus derived suppressor lymphocytes in human cord blood  Academic Article
• Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3  Academic Article
• Actively transcribed genes in the raf oncogene group, located on the x-chromosome in mouse and human  Academic Article
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• Activity of hoechst 33258 against Pneumocystis carinii f. sp muris, Candida albicans, and Candida dubliniensis  Academic Article
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• Activity-based labeling of matrix metalloproteinases in living vertebrate embryos  Academic Article
• Activity-based probes for proteomic profiling of histone deacetylase complexes  Academic Article
• Activity-based probes for the proteomic profiling of metalloproteases  Academic Article
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• Activity-based protein profiling for the functional annotation of enzymes  Academic Article
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• Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne 3+2 cycloaddition  Academic Article
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• Acute antihypertensive and renal effects of isradipine in hypertensive patients with normal and reduced renal function  Academic Article
• Acute coronary syndromes in the gusto-iib trial - prognostic insights and impact of recurrent ischemia  Academic Article
• Acute effects of alcohol on P300 in Asians with different ALDH2 genotypes  Academic Article
• Acute hemolysis after receiving oxaliplatin treatment: a case report and literature review  Academic Article
• Acute intervention during myocardial-infarction in patients with prior coronary-bypass surgery  Academic Article
• Acute intervention for myocardial-infarction  Academic Article
• Acute ischemic heart disease - cardiogenic shock complicating acute myocardial infarction: Predictors of death  Academic Article
• Acute monoblastic leukemia with skin nodules in an adult  Academic Article
• Acute myelofibrosis - treatment with allogeneic bone-marrow transplantation  Academic Article
• Acute myocardial infarction and complete bundle branch block at hospital admission: Clinical characteristics and outcome in the thrombolytic  Academic Article
• Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I  Academic Article
• Acute renal failure in severe pancreatitis: a population-based study  Academic Article
• Acute-phase responses in transgenic mice with CNS overexpression of IL-1 receptor antagonist  Academic Article
• Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data  Academic Article
• Adaptation of a CCR5-using, primary human immunodeficiency virus type 1 isolate for CD4-independent replication  Academic Article
• Adaptation of energy metabolism in breast cancer brain metastases  Academic Article
• Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid)  Academic Article
• Adaptation of influenza viruses to human airway receptors  Academic Article
• Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-- Jakob disease: implications for human health  Academic Article
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• Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2  Academic Article
• Adapting proteostasis for disease intervention  Academic Article
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• Adaptive immune responses mediated by natural killer cells  Academic Article
• Adaptive partitioning QM/MM dynamics simulations for substrate uptake, product release, and solvent exchange  Academic Article
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• Addictions biology: Haplotype-based analysis for 130 candidate genes on a single array  Academic Article
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• Adenosine: a partial agonist of the growth hormone secretagogue receptor  Academic Article
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• Adenoviral-mediated transfer of tgf-beta 1 but not igf-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures  Academic Article
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• Adenovirus fiber shaft contains a trimerization element that supports peptide fusion for targeted gene delivery  Academic Article
• Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells  Academic Article
• Adenovirus internalization and infection require dynamin  Academic Article
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• Adenovirus protein vi mediates membrane disruption following capsid disassembly  Academic Article
• Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice  Academic Article
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• Adjuncts to thrombolysis for myocardial reperfusion  Academic Article
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• Admixture mapping as a gene discovery approach for complex human traits and diseases  Academic Article
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• Adp-ribosylation factor is required for vesicular trafficking between the endoplasmic-reticulum and the cis-golgi compartment  Academic Article
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• Advances in the treatment of Clostridium difficile with fidaxomicin: a narrow spectrum antibiotic  Academic Article
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• Advances in treatment and management: Immunologic and cell-based regenerative therapies  Academic Article
• Advances in understanding the complex mechanisms of DNA interstrand cross-link repair  Academic Article
• Advancing a neurodevelopmental origin for schizophrenia  Academic Article
• Advancing biological understanding and therapeutics discovery with small-molecule probes  Academic Article
• Advancing cancer patient care by integrating circulating tumor cell technology to understand the spatial and temporal dynamics of cancer  Academic Article
• Advancing computational biology and bioinformatics research through open innovation competitions  Academic Article
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• Adverse events to antiretrovirals in the Swiss HIV Cohort Study: Effect on mortality and treatment modification  Academic Article
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• Affective picture processing: An integrative review of erp findings  Academic Article
• Affective recognition memory processing and event-related brain potentials  Academic Article
• Affective valence, stimulus attributes, and p300: Color vs. Black/white and normal vs. Scrambled images  Academic Article
• Affective visual event-related potentials: Arousal, repetition, and time-on-task  Academic Article
• Affective visual event-related potentials: Arousal, valence, and repetition effects for normal and distorted pictures  Academic Article
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• Age and outcome with contemporary thrombolytic therapy - results from the gusto-i trial  Academic Article
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• Age of first marijuana use and the occurrence of marijuana use disorders in Southwest California Indians  Academic Article
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• Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design  Academic Article
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• Broad neutralization of SARS-related viruses by human monoclonal antibodies  Academic Article
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• Cachectin tumor-necrosis-factor - an endogenous mediator of shock and inflammation  Academic Article
• Cachectin, cachexia, and shock  Academic Article
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• Cachectin: the dark side of tumor necrosis factor  Academic Article
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• Cadherin 23 is a component of the tip link in hair-cell stereocilia  Academic Article
• Cadherins and mechanotransduction by hair cells  Academic Article
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• Calcitonin gene-related peptide is metabolized by an endopeptidase hydrolyzing substance-p  Academic Article
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• Calcium, free radicals and excitotoxins in neuronal apoptosis  Academic Article
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• Cancer CARtography: charting out a new approach to cancer immunotherapy  Academic Article
• Cancer driver mutations in protein kinase genes  Academic Article
• Cancer gene therapy using a novel secretable trimeric trail  Academic Article
• Cancer genes  Academic Article
• Cancer genetics may aid diagnostics of developmental disorders  Academic Article
• Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape  Academic Article
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• Cancer-specific mutations in phosphatidylinositol 3-kinase  Academic Article
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• Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: An expanded convergent functional genomics approach  Academic Article
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• Capitalizing on knowledge of hepatitis C virus neutralizing epitopes for rational vaccine design  Academic Article
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• Cloning of a human cdna-encoding a cdc2-related kinase by complementation of a budding yeast cdc28 mutation  Academic Article
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• Cloning of cdnas for m-phase phosphoproteins recognized by the mpm2 monoclonal-antibody and determination of the phosphorylated epitope  Academic Article
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• Cloning of the murine platelet glycoprotein Ib alpha gene highlighting species-specific platelet adhesion  Academic Article
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• Cloning, expression, and characterization of human apolipoprotein(a) kringle iv37  Academic Article
• Cloning, expression, and purification of monoclonal antibodies in scFv-Fc format  Academic Article
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• Clopidogrel added to aspirin versus aspirin alone in secondary prevention and high-risk primary prevention: Rationale and design of the clopidogrel for high atherothrombotic risk and ischemic stabilization, management, and avoidance (charisma) trial  Academic Article
• Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events  Academic Article
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• Clopidogrel with aspirin is the optimal antiplatelet regimen for intracoronary stenting  Academic Article
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• Clot-selective coronary thrombolysis with pro-urokinase  Academic Article
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• Complementation of defective leucine decarboxylation in fibroblasts from a maple syrup urine disease patient by retrovirus-mediated gene transfer  Academic Article
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• Complete amino-acid sequence of a human monocyte chemoattractant, a putative mediator of cellular immune-reactions  Academic Article
• Complete atrioventricular-block complicating inferior wall acute myocardial-infarction treated with reperfusion therapy  Academic Article
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• Conformational adaptation of human cytochrome p450 2b6 and rabbit cytochrome p450 2b4 revealed upon binding multiple amlodipine molecules  Academic Article
• Conformational and structural modulation of nh2-terminal regions of fibrinogen and fibrin associated with plasmin cleavage  Academic Article
• Conformational changes in fibrinogen elicited by its interaction with platelet membrane glycoprotein GPIIb-IIIa  Academic Article
• Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency  Academic Article
• Conformational changes in the A1 domain of von Willebrand factor modulating the interaction with platelet glycoprotein Ibα  Academic Article
• Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding  Academic Article
• Conformational changes of gp120 in epitopes near the ccr5 binding site are induced by cd4 and a cd4 miniprotein mimetic  Academic Article
• Conformational constraints imposed on a pan-neutralizing hiv-1 antibody epitope result in increased antigenicity but not neutralizing response  Academic Article
• Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding  Academic Article
• Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions  Academic Article
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• Conformational isomerism can limit antibody catalysis  Academic Article
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• Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: Receptor-selective somatostatin analogues  Academic Article
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• Confronting the issues of patient safety and investigator conflict-of-interest in an international clinical-trial of myocardial reperfusion  Academic Article
• Congenital disease snps target lineage specific structural elements in protein kinases  Academic Article
• Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms  Academic Article
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• Conjunctive use of platelet glycoprotein IIb/IIIa antagonists and thrombolytic therapy for acute myocardial infarction  Academic Article
• Connectivity and complexity: The relationship between neuroanatomy and brain dynamics  Academic Article
• Connexin mediated cataract prevention in mice  Academic Article
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• Conquering Atherosclerotic Cardiovascular Disease-50 Years of Progress  Academic Article
• Consensus generation and variant detection by celera assembler  Academic Article
• Consequences of reocclusion after successful reperfusion therapy in acute myocardial-infarction  Academic Article
• Consequences of secondary or coinfections for immunity  Academic Article
• Consequences of the loss of o-linked glycosylation of meningococcal type iv pilin on piliation and pilus-mediated adhesion  Academic Article
• Conservation of function and regulation within the cdc28/cdc2 protein-kinase family - characterization of the human cdc2hs protein-kinase in saccharomyces-cerevisiae  Academic Article
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• Conservation of the low-density-lipoprotein receptor-binding domain of apoprotein-b - demonstration by a new monoclonal-antibody, mb47  Academic Article
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• Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors  Academic Article
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• Conserved changes in envelope function during human immunodeficiency virus type 1 coreceptor switching  Academic Article
• Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation  Academic Article
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• Conserved functions of membrane active gtpases in coated vesicle formation  Academic Article
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• Conserved regulation of the lymphocyte-specific expression of lck in the Fugu and mammals  Academic Article
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• Contribution of five amino acid residues in the glutathione-binding site to the function of human glutathione transferase P1-1  Academic Article
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• Coronary angioplasty as therapy for acute myocardial infarction: University of Michigan experience  Academic Article
• Coronary angioplasty for acute myocardial-infarction  Academic Article
• Coronary angioplasty in myocardial infarction  Academic Article
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• Coronary arterial thrombolysis with combined infusion of recombinant tissue-type plasminogen-activator and urokinase in patients with acute myocardial-infarction  Academic Article
• Coronary artery stents  Academic Article
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• Correlation between base-line plasminogen-activator inhibitor levels and clinical outcome during therapy with tissue plasminogen-activator for acute myocardial-infarction  Academic Article
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• Cost-efficacy modeling of catheter reuse for percutaneous transluminal coronary angioplasty  Academic Article
• Costly mistakes: translational infidelity and protein homeostasis  Academic Article
• Coumarin derivatives as substrate probes of mammalian cytochromes P450 2B4 and 2B6: assessing the importance of 7-Alkoxy chain length, halogen substitution, and non-active site mutations  Academic Article
• Coumarin necrosis, neonatal purpura fulminans, and protein C deficiency  Academic Article
• Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus  Academic Article
• Counteraction of HLA-C-mediated immune control of HIV-1 by Nef  Academic Article
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• Coupling of folding and binding for unstructured proteins  Academic Article
• Coupling of receptor conformation and ligand orientation determine graded activity  Academic Article
• Coupling of the adhesive receptor cd11b/cd18 to functional enhancement of effector macrophage tissue factor response  Academic Article
• Course and prognosis in patients >=70 years of age with congestive heart failure and normal versus abnormal left ventricular ejection fraction  Academic Article
• Covalent inhibitors: an opportunity for rational target selectivity  Academic Article
• Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products  Academic Article
• Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions  Academic Article
• Coxsackievirus B exits the host cell in shed microvesicles displaying autophagosomal markers  Academic Article
• Coxsackievirus B3 proteins directionally complement each other to downregulate surface major histocompatibility complex class I  Academic Article
• Coxsackievirus b3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the mhc class i pathway  Academic Article
• Coxsackievirus can exploit LC3 in both autophagy-dependent and -independent manners in vivo  Academic Article
• Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo  Academic Article
• Coxsackievirus infection of the pancreas: Evaluation of receptor expression, pathogenesis, and immunopathology  Academic Article
• Coxsackievirus replication and the cell cycle: A potential regulatory mechanism for viral persistence/latency  Academic Article
• CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene  Academic Article
• Cr-2 is a complement activator and the covalent binding-site for c-3 during alternative pathway activation by raji cells  Academic Article
• Craving in response to stress induction in a human laboratory paradigm predicts treatment outcome in alcohol-dependent individuals  Academic Article
• Craving, context and the cortex  Academic Article
• Creatine kinase-mb elevation after coronary artery bypass grafting surgery in patients with non-st-segment elevation acute coronary syndromes predict worse outcomes: Results from four large clinical trials  Academic Article
• Creatine kinase-mb elevation after percutaneous coronary intervention predicts adverse outcomes in patients with acute coronary syndromes  Academic Article
• Creatine-kinase mm and mb isoforms in patients receiving thrombolytic therapy and acute angiography  Academic Article
• Creation of a large-scale genetic data bank for cardiovascular association studies  Academic Article
• Creep of trabecular bone from the human proximal tibia  Academic Article
• Creutzfeldt-Jakob disease  Academic Article
• Criteria for environmentally associated autoimmune diseases  Academic Article
• Critical evaluation of bispecific antibodies as targetins agents for boron neutron capture therapy of brain tumors  Academic Article
• Critical role for conversion of Glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces  Academic Article
• Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity  Academic Article
• Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG  Academic Article
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• Cross-linking of lipopolysaccharide (lps) to cd14 on thp-1 cells mediated by lps-binding protein  Academic Article
• Cross-neutralization of human and palm civet severe acute respiratory syndrome coronaviruses by antibodies targeting the receptor-binding domain of spike protein  Academic Article
• Cross-neutralizing activity of human anti-V3 monoclonal antibodies derived from non-B clade HIV-1 infected individuals  Academic Article
• Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections 
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• Cross-reactive epitope with klebsiella-pneumoniae nitrogenase in articular tissue of hla-b27+ patients with ankylosing-spondylitis  Academic Article
• Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection  Academic Article
• Cross-reactivity between hl-a and h-2 antigens. Ii. Allogeneic sensitization by xenogeneic soluble lymphocyte antigens (hl-a)  Academic Article
• Cross-talk between IRAK-4 and the NADPH oxidase  Academic Article
• Cross-talk between intraepithelial gamma delta T cells and epithelial cells  Academic Article
• Cross-talk between receptor tyrosine kinase and tumor necrosis factor-α signaling networks regulates apoptosis but not proliferation  Academic Article
• Cross-talk between snurportin1 subdomains  Academic Article
• Cross-talk of integrin alpha 3 beta 1 and tissue factor in cell migration  Academic Article
• Crowdsourcing in biomedicine: challenges and opportunities  Academic Article
• Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer  Academic Article
• Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating  Academic Article
• Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome  Academic Article
• Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: The IRES functions as an RNA-Based translation factor  Academic Article
• Cryo-electron microscopy structure of adenovirus type 2 temperature-sensitive mutant 1 reveals insight into the cell entry defect  Academic Article
• Cryo-em visualization of an exposed rgd epitope on adenovirus that escapes antibody neutralization  Academic Article
• Cryopreservation by slow cooling with dmso diminished production of oct-4 pluripotency marker in human embryonic stem cells  Academic Article
• Cryopreservation of cancer-initiating cells derived from glioblastoma  Academic Article
• Cryopreservation of human mucosal tissues  Academic Article
• Cryopreservation of neurospheres derived from human glioblastoma multiforme  Academic Article
• Cryptochromes mediate rhythmic repression of the glucocorticoid receptor  Academic Article
• Cryptochromes: bringing the blues to circadian rhythms  Academic Article
• Crystal structure and activity studies of the C11 cysteine peptidase from parabacteroides merdae in the human gut microbiome  Academic Article
• Crystal structure and mutational analysis of the saccharomyces cerevisiae cell cycle regulatory protein cks1: Implications for domain swapping, anion binding and protein interactions  Academic Article
• Crystal structure and mutational analysis the human cdk2 kinase complex with cell cycle-regulatory protein ckshs1  Academic Article
• Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase  Academic Article
• Crystal structure of 3-hydroxyanthranilic acid 3,4-dioxygenase from saccharomyces cerevisiae: A special subgroup of the type III extradiol dioxygenases  Academic Article
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• Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif  Academic Article
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• Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution  Academic Article
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• Crystal structure of a human aminoacyl-tRNA synthetase cytokine  Academic Article
• Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity  Academic Article
• Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design  Academic Article
• Crystal structure of a soluble cleaved HIV-1 envelope trimer  Academic Article
• Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3  Academic Article
• Crystal structure of an alanine-glyoxylate aminotransferase from anabaena sp at 1.70 A resolution reveals a noncovalently linked PLP cofactor  Academic Article
• Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design  Academic Article
• Crystal structure of antagonist bound human lysophosphatidic acid receptor 1  Academic Article
• Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening  Academic Article
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• Crystal structure of human cytochrome p450 2d6 with prinomastat bound  Academic Article
• Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping  Academic Article
• Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue  Academic Article
• Crystal structure of human ornithine transcarbamylase complexed with carbamoyl phosphate and L-norvaline at 1.9 A resolution  Academic Article
• Crystal structure of human seryl-tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes  Academic Article
• Crystal structure of human toll-like receptor 3 (tlr3) ectodomain  Academic Article
• Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A  Academic Article
• Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites  Academic Article
• Crystal structure of human vinculin  Academic Article
• Crystal structure of misoprostol bound to the labor inducer prostaglandin E-2 receptor  Academic Article
• Crystal structure of mouse cd1: An mhc-like fold with a large hydrophobic binding groove  Academic Article
• Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (trem-1) at 1.76 Å  Academic Article
• Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser  Academic Article
• Crystal structure of tetrameric form of human lysyl-tRNA synthetase: implications for multisynthetase complex formation  Academic Article
• Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain  Academic Article
• Crystal structure of the C-terminal domain of mouse TLR9  Academic Article
• Crystal structure of the Frizzled 4 receptor in a ligand-free state  Academic Article
• Crystal structure of the N-terminal domains of the surface cell antigen 4 of Rickettsia  Academic Article
• Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide  Academic Article
• Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran  Academic Article
• Crystal structure of the anti-viral apobec3g catalytic domain and functional implications  Academic Article
• Crystal structure of the broadly cross-reactive hiv-1-neutralizing fab x5 and fine mapping of its epitope  Academic Article
• Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine  Academic Article
• Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin a  Academic Article
• Crystal structure of the cyclostreptin-tubulin adduct: implications for tubulin activation by taxane-site ligands  Academic Article
• Crystal structure of the human 4-1BB/4-1BBL complex  Academic Article
• Crystal structure of the human TRPV2 channel ankyrin repeat domain  Academic Article
• Crystal structure of the human n-myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor  Academic Article
• Crystal structure of the il-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor  Academic Article
• Crystal structure of the lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding  Academic Article
• Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A  Academic Article
• Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases  Academic Article
• Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 Å resolution: Self-hydroxylation of phe300 and the pterin-binding site  Academic Article
• Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin  Academic Article
• Crystal structure of viral macrophage inflammatory protein i encoded by kaposi's sarcoma-associated herpesvirus at 1.7 a  Academic Article
• Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34  Academic Article
• Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor  Academic Article
• Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis  Academic Article
• Crystal structures of a quorum-quenching antibody  Academic Article
• Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR  Academic Article
• Crystal structures of human HSP90 alpha-complexed with dihydroxyphenylpyrazoles  Academic Article
• Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates  Academic Article
• Crystal structures of human immunodeficiency virus type 1 (hiv-1) neutralizing antibody 2219 in complex with three different v3 peptides reveal a new binding mode for hiv-1 cross-reactivity  Academic Article
• Crystal structures of human topoisomerase i in covalent and noncovalent complexes with DNA  Academic Article
• Crystal structures of mouse CD1d-iGb3 complex and its cognate v alpha 14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids  Academic Article
• Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands  Academic Article
• Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors  Academic Article
• Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain  Academic Article
• Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains  Academic Article
• Crystal-structure and mutational analysis of human uracil-DNA glycosylase - structural basis for specificity and catalysis  Academic Article
• Crystal-structure of human uracil-DNA glycosylase in complex with a protein inhibitor - protein mimicry of DNA  Academic Article
• Crystal-structure of murine cyclophilin-c complexed with immunosuppressive drug cyclosporine-a  Academic Article
• Crystal-structure of the human cell-cycle protein ckshs1 - single-domain fold with similarity to kinase n-lobe domain  Academic Article
• Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease  Academic Article
• Crystallization and preliminary X-ray analysis of human carbonic anhydrase III  Academic Article
• Crystallization and preliminary X-ray diffraction analysis of human adenovirus  Academic Article
• Crystallization and preliminary crystallographic study of human ckshs1 - a cell-cycle regulatory protein  Academic Article
• Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: An antibody that broadly neutralizes primary isolates of HIV-1  Academic Article
• Crystallization and preliminary-x-ray analysis of the cytoplasmic domain of human erythrocyte band-3  Academic Article
• Crystallization and preliminary-x-ray diffraction studies of a complex between interleukin-2 and a soluble form of the p55 component of the high-affinity interleukin-2 receptor  Academic Article
• Crystallization of GST2, a human class alpha glutathione transferase  Academic Article
• Crystallization of HLA-DR4 fused to an immunodominant collagen ll peptide implicated in rheumatoid arthritis  Academic Article
• Crystallization of membrane proteins in lipidic mesophases  Academic Article
• Crystallization of trimeric recombinant human-tumor necrosis factor (cachectin)  Academic Article
• Crystallization studies of glycosylated and unglycosylated human recombinant interleukin-2  Academic Article
• Crystallizing membrane proteins using lipidic mesophases  Academic Article
• Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 Å resolution  Academic Article
• Crystallographic and biochemical analysis of cocaine-degrading antibody l5a10  Academic Article
• Crystallographic and computational analyses of AUUCU repeating RNA that causes spinocerebellar ataxia type 10 (SCA10)  Academic Article
• Crystallographic characterization of recombinant human CuZn superoxide-dismutase  Academic Article
• Crystallographic fragment-based drug discovery: use of a brominated fragment library targeting HIV protease  Academic Article
• Crystallographic identification of lipid as an integral component of the epitope of HIV broadly neutralizing antibody 4E10  Academic Article
• Crystallographic studies of bovine beta-2-microglobulin  Academic Article
• Crystallohydrodynamics for solving the hydration problem for multi-domain proteins: Open physiological conformations for human IgG  Academic Article
• Csf beta-endorphins in childhood neuropsychiatric disorders  Academic Article
• CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity  Academic Article
• CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks  Academic Article
• Cta1-dd adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization  Academic Article
• Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination  Academic Article
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• Curing a viral infection by targeting the host: The example of cyclophilin inhibitors  Academic Article
• Current V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates  Academic Article
• Current challenges for the creation of effective vaccines against drugs of abuse  Academic Article
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• Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes  Academic Article
• Current status and future prospects for acute myocardial infarction therapy  Academic Article
• Current status of available standards for quality improvement of assays for detection of autoantibodies to nuclear and intracellular antigens  Academic Article
• Current strategies for microRNA research  Academic Article
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• Current understanding of sepsis  Academic Article
• Current views on the pathogenesis of systemic lupus-erythematosus  Academic Article
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• Custom zinc-finger nucleases for use in human cells  Academic Article
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• Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide  Academic Article
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• Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3  Academic Article
• Cvak104 is a novel poly-l-lysine-stimulated kinase that targets the beta 2-subunit of ap2  Academic Article
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• Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy  Academic Article
• Cyclic marinopyrrole derivatives as disruptors of Mcl-1 and Bcl-x(L) binding to Bim  Academic Article
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• Cyclin E: In mid-cycle  Academic Article
• Cyclin I is an RS domain protein involved in pre-mRNA splicing  Academic Article
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• Cyclin e-induced s phase without activation of the prb/e2f pathway  Academic Article
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• Cyclophilin inhibitors for the treatment of HCV infection  Academic Article
• Cyclophilin inhibitors: A novel class of promising host-targeting anti-HCV agents  Academic Article
• Cyclophilin inhibitors: An emerging class of therapeutics for the treatment of chronic hepatitis C infection  Academic Article
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• Cysteine cathepsins in the secretory vesicle produce active peptides: cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease  Academic Article
• Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors  Academic Article
• Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain  Academic Article
• Cysteine regulation of protein function - as exemplified by NMDA-receptor modulation  Academic Article
• Cysteine residues are not essential for the catalytic activity of human class Mu glutathione transferase M1a-1a  Academic Article
• Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery  Academic Article
• Cysteine-specific chemical proteomics: from target identification to drug discovery  Academic Article
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• Cystic fibrosis therapy: a community ecology perspective  Academic Article
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• Cytogenetic characterization of B-cell lymphomas from severe combined immunodeficiency disease mice given injections of lymphocytes from Epstein-Barr virus-positive donors  Academic Article
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• Cytokine gene-therapy with interleukin-2-transduced fibroblasts - effects of il-2 dose on antitumor immunity  Academic Article
• Cytokine receptor dimerization and activation: prospects for small molecule agonists  Academic Article
• Cytokine regulation of facilitated glucose transport in human articular chondrocytes  Academic Article
• Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct jak kinase signaling pathways  Academic Article
• Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells  Academic Article
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• Cytokine-mediated control of viral infections  Academic Article
• Cytokine-sensitive replication of hepatitis B virus in immortalized mouse hepatocyte cultures  Academic Article
• Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of L-cysteine  Academic Article
• Cytokines and cancer cachexia  Academic Article
• Cytokines and t cell homeostasis  Academic Article
• Cytokines and t-cell homeostasis  Academic Article
• Cytokines in cartilage injury and repair  Academic Article
• Cytokines in neuronal cell types  Academic Article
• Cytokines in symptomatic asthma airways  Academic Article
• Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex  Academic Article
• Cytomegalovirus infects human-lymphocytes and monocytes - virus expression is restricted to immediate-early gene-products  Academic Article
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• Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes  Academic Article
• Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa-induced lung injury in mice  Academic Article
• Cytoprotective-selective activated protein C therapy for ischaemic stroke  Academic Article
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• Cytosol- and clathrin-dependent stimulation of endocytosis in vitro by purified adaptors  Academic Article
• Cytotoxic T cells and viral hepatitis  Academic Article
• Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif  Academic Article
• Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection  Academic Article
• Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen  Academic Article
• Cytotoxic T-lymphocyte response to a wild-type hepatitis-B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope  Academic Article
• Cytotoxic lymphocytes generated in vivo with acute measles virus infection  Academic Article
• Cytotoxicity of a Ti(IV) compound is independent of serum proteins  Academic Article
• Cytotoxicity of quantum dots used for in vitro cellular labeling: role of QD surface ligand, delivery modality, cell type, and direct comparison to organic fluorophores  Academic Article
• D-4 dopamine receptor high-resolution structures enable the discovery of selective agonists  Academic Article
• D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine  Academic Article
• D-amino acid oxidase activator gene (daoa) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy caucasians  Academic Article
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• D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis  Academic Article
• DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid  Academic Article
• DAMB, a novel dopamine receptor expressed specifically in Drosophila mushroom bodies  Academic Article
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• DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain  Academic Article
• DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras  Academic Article
• DCAF4, a novel gene associated with leucocyte telomere length  Academic Article
• DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement  Academic Article
• DDAVP enhances platelet adherence and platelet aggregate growth on human artery subendothelium  Academic Article
• DDAVP in haemophilia  Academic Article
• DDX1 is an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication  Academic Article
• DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A  Academic Article
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• DISC1 regulates trafficking and processing of APP and Aβ generation  Academic Article
• DISCovery in psychiatric genetics  Academic Article
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• DNA arrays: applications and implications for circadian biology  Academic Article
• DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex  Academic Article
• DNA binding and nucleotide flipping by the human DNA repair protein agt  Academic Article
• DNA binding domain in the replication checkpoint protein Mrc1 of Schizosaccharomyces pombe  Academic Article
• DNA binding fluorescent proteins for the direct visualization of large DNA molecules  Academic Article
• DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by o-6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy  Academic Article
• DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Kruppel-like factor 15 gene expression  Academic Article
• DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes  Academic Article
• DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3  Academic Article
• DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands  Academic Article
• DNA double-strand break repair pathway choice Is directed by distinct MRE11 nuclease activities  Academic Article
• DNA immunization: Mechanistic studies  Academic Article
• DNA loops induced by cooperative binding of transcriptional activator proteins and preinitiation complexes  Academic Article
• DNA methylation analysis of human myoblasts during in vitro myogenic differentiation: de novo methylation of promoters of muscle-related genes and its involvement in transcriptional down-regulation  Academic Article
• DNA methylation and chromatin structure regulate T cell perforin gene expression  Academic Article
• DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights  Academic Article
• DNA methylation in embryonic stem cells  Academic Article
• DNA polymerase activity assay using near-infrared fluorescent labeled DNA visualized by acrylamide gel electrophoresis  Academic Article
• DNA polymerase activity at the single-molecule level  Academic Article
• DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes  Academic Article
• DNA repair is crucial for maintaining hematopoietic stem cell function  Academic Article
• DNA repair mechanisms for the recognition and removal of damaged DNA bases  Academic Article
• DNA replication checkpoint  Academic Article
• DNA replication checkpoint control  Academic Article
• DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia  Academic Article
• DNA vaccination to treat autoimmune diabetes  Academic Article
• DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the nkg2d receptor  Academic Article
• DNA-binding property of Sm nuclear antigen  Academic Article
• DNA-binding proteins in human-serum  Academic Article
• DNA-bound structures and mutants reveal abasic DNA binding by ape1 DNA repair and coordination  Academic Article
• DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer  Academic Article
• DNA-repair proteins  Academic Article
• DNase I inhibits a late phase of reactive oxygen species production in neutrophils  Academic Article
• DOLORS: versatile strategy for internal labeling and domain localization in electron microscopy  Academic Article
• DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis  Academic Article
• DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells  Academic Article
• DUBs, the regulation of cell identity and disease  Academic Article
• DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes  Academic Article
• Daily eating patterns and their impact on health and disease  Academic Article
• Damage to the bases in DNA induced by stimulated human neutrophils  Academic Article
• Daring to learn from humanized mice  Academic Article
• Database searching using mass spectrometry data  Academic Article
• Dax1 mutations map to putative structural domains in a deduced three-dimensional model  Academic Article
• Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint  Academic Article
• De novo KCNB1 mutations in epileptic encephalopathy  Academic Article
• De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts  Academic Article
• De novo identification of tumor-specific internalizing human antibody-receptor pairs by phage-display methods  Academic Article
• De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years  Academic Article
• De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters  Academic Article
• De-novo humoral immune responses to cancer-associated autoantigens during transition from chronic liver disease to hepatocellular carcinoma  Academic Article
• Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: Experience from gusto-iib  Academic Article
• Death following creatine kinase-mb elevation after coronary intervention - identification of an early risk period: Importance of creatine kinase-mb level, completeness of revascularization, ventricular function, and probable benefit of statin therapy  Academic Article
• Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function  Academic Article
• Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis  Academic Article
• Death-associated proteins: from gene identification to the analysis of their apoptotic and tumour suppressive functions  Academic Article
• Deciphering poxvirus gene expression by RNA sequencing and ribosome profiling  Academic Article
• Deciphering the chromatin landscape induced around DNA double strand breaks  Academic Article
• Deciphering the interaction of the corticotropin-releasing factor and serotonin brain systems in anxiety-related disorders  Academic Article
• Decoding arenavirus pathogenesis: Essential roles for alpha-dystroglycan-virus interactions and the immune response  Academic Article
• Decoding human cytomegalovirus  Academic Article
• Deconstructing schizophrenia: An overview of the use of endophenotypes in order to understand a complex disorder  Academic Article
• Deconvoluting post-transplant immunity: Cell subset-specific mapping reveals pathways for activation and expansion of memory t, monocytes and b cells  Academic Article
• Decrease in measles virus-specific cd4 t cell memory in vaccinated subjects  Academic Article
• Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase  Academic Article
• Decreased cure and increased recurrence rates for Clostridium difficile infection caused by the epidemic C. difficile BI strain  Academic Article
• Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia  Academic Article
• Decreased frequency of rearrangement due to the synergistic effect of nucleotide changes in the heptamer and nonamer of the recombination signal sequence of the V kappa gene A2B, which is associated with increased susceptibility of navajos to haemophilus influenzae type B disease  Academic Article
• Decreased glutathione and elevated hair mercury levels are associated with nutritional deficiency-based autism in Oman  Academic Article
• Decreased insulin production, elevated growth hormone levels, and glucose intolerance in liver disease  Academic Article
• Decreased knee adduction moment does not guarantee decreased medial contact force during gait  Academic Article
• Decreased perihematomal edema in thrombolysis-related intracerebral hemorrhage compared with spontaneous intracerebral hemorrhage  Academic Article
• Decreased plasma levels of protein S in well-controlled type I diabetes mellitus  Academic Article
• Decreased plasma sensitivity to activated protein C by oral contraceptives is associated with decreases in plasma glucosylceramide  Academic Article
• Decreased production of nitric oxide by human neutrophils during septic multiple organ dysfunction syndrome. Comparison with endotoxin and cytokine effects on normal cells  Academic Article
• Deep interactome profiling of membrane proteins by co-interacting protein identification technology  Academic Article
• Deep mutational scanning: a new style of protein science  Academic Article
• Deep nuclear invaginations are linked to cytoskeletal filaments - integrated bioimaging of epithelial cells in 3D culture  Academic Article
• Deep sequencing of protease inhibitor resistant HIV patient isolates reveals patterns of correlated mutations in Gag and protease  Academic Article
• Defective Th1 cytokine gene transcription in CD4(+) and CD8(+) T cells from wiskott-aldrich syndrome patients  Academic Article
• Defective dimerization of von Willebrand factor subunits due to a Cys -> Arg mutation in type IID von Willebrand disease  Academic Article
• Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function  Academic Article
• Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation  Academic Article
• Defects in deletional tolerance of CD8+ T cells in autoimmune diabetes  Academic Article
• Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist  Academic Article
• Defensive spiroketals from Asceles glaber (Phasmatodea): absolute configuration and effects on ants and mosquitoes  Academic Article
• Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy  Academic Article
• Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances  Academic Article
• Deficiency of factor-XII-dependent plasminogen proactivator in prekallikrein-deficient plasma  Academic Article
• Deficiency of lrp8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis  Academic Article
• Deficiency of protein-C in congenital thrombotic disease  Academic Article
• Defined and scalable differentiation of human oligodendrocyte precursors from pluripotent stem cells in a 3D culture system  Academic Article
• Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation  Academic Article
• Defining HIV-1 protease substrate selectivity  Academic Article
• Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing  Academic Article
• Defining actin filament length in striated muscle: rulers and caps or dynamic stability?  Academic Article
• Defining antibody-antigen recognition: towards engineered antibodies and epitopes  Academic Article
• Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays  Academic Article
• Defining parameters for successful immunocytotherapy of persistent viral infection  Academic Article
• Defining the appropriate threshold of creatine kinase elevation after percutaneous coronary interventions  Academic Article
• Defining the communication between agonist and coactivator binding in the retinoid X receptor alpha ligand binding domain  Academic Article
• Defining the conformational features of anchorless, poorly neuroinvasive prions  Academic Article
• Defining the metabolome: size, flux, and regulation  Academic Article
• Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals  Academic Article
• Defining the optimal activated clotting time during percutaneous coronary intervention - aggregate results from 6 randomized, controlled trials  Academic Article
• Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome  Academic Article
• Defining the risks of mesenchymal stromal cell therapy  Academic Article
• Defining the role of oxygen tension in human neural progenitor fate  Academic Article
• Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein  Academic Article
• Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22  Academic Article
• Degeneracy and complexity in biological systems  Academic Article
• Degenerate immunogenicity of an HLA-A2-restricted hepatitis B virus nucleocapsid cytotoxic T-lymphocyte epitope that is also presented by HLA-B51  Academic Article
• Degradable conjugates from oxanorbornadiene reagents  Academic Article
• Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death  Academic Article
• Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis  Academic Article
• Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels  Academic Article
• Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity  Academic Article
• Delayed and accelerated aging share common longevity assurance mechanisms  Academic Article
• Deletion mutants of human interleukin 1β with significantly reduced agonist properties: Search for the agonist/antagonist switch in ligands to the interleukin 1 receptors  Academic Article
• Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice  Academic Article
• Deletion of amino acids glu146 -> arg160 in human apolipoprotein a-i (apoa-i-seattle) alters lecithin : Cholesterol acyltransferase activity and recruitment of cell phospholipid  Academic Article
• Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice  Academic Article
• Deletions linked to TP53 loss drive cancer through p53-independent mechanisms  Academic Article
• Deletions within the 5 ' utr of coxsackievirus b3: Consequences for virus translation and replication  Academic Article
• Delineating the susceptibility of botulinum neurotoxins to denaturation through thermal effects  Academic Article
• Delineation of 3 classes of cea antigenic determinants - identification of membrane-associated cea as an independent species of cea  Academic Article
• Delineation of suppressor and helper activity within the okt4-defined lymphocyte-t subset in human newborns  Academic Article
• Delineation of the peptide binding site of the human galanin receptor  Academic Article
• Delivering quantum dot-peptide bioconjugates to the cellular cytosol: escaping from the endolysosomal system  Academic Article
• Delivering the kiss of death: Progress on understanding how perforin works  Academic Article
• Delivery of proteases in aqueous two-phase systems enables direct purification of stem cell colonies from feeder cell co-cultures for differentiation into functional cardiomyocytes  Academic Article
• Delta-9,11 modification of glucocorticoids dissociates nuclear factor-κB inhibitory efficacy from glucocorticoid response element-associated side effects  Academic Article
• Dementia associated with the acquired immunodeficiency syndrome  Academic Article
• Demonstration of circulating immune complexes in Sjögren's syndrome  Academic Article
• Demonstration of functional similarity of proposed biosimilar ABP 501 to adalimumab  Academic Article
• Denaturant-induced stimulation of the beta-migrating plasminogen activator inhibitor in endothelial cells and serum  Academic Article
• Denaturation of dsdna by p53: Fluorescence correlation spectroscopy study  Academic Article
• Dendritic arbor development and synaptogenesis  Academic Article
• Dendritic cell inhibition: Memoirs from immunosuppressive viruses  Academic Article
• Dendritic cell-secreted cytotoxic T-lymphocyte-associated protein-4 regulates the T-cell response by downmodulating bystander surface B7  Academic Article
• Dendritic cells transduced with an adenovirus vector encoding Epstein-Barr virus latent membrane protein 2B: A new modality for vaccination  Academic Article
• Dendritic epidermal t-cell activation  Academic Article
• Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin  Academic Article
• Denovo refractory ventricular tachyarrhythmias after coronary revascularization  Academic Article
• Dense array of spikes on HIV-1 virion particles  Academic Article
• Dental caries and microbial acid production in twins  Academic Article
• Dental caries pathogenicity: A genomic and metagenomic perspective  Academic Article
• Dentin conditioning codetermines cell fate in regenerative endodontics  Academic Article
• Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus  Academic Article
• Deoxyribonucleic acid antibody: a method to detect its primary interaction with deoxyribonucleic acid  Academic Article
• Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5'-diphosphate receptor stimulation and cyclic calcium signaling  Academic Article
• Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors  Academic Article
• Depletion of calcium from the lumen of endoplasmic-reticulum reversibly inhibits passive diffusion and signal-mediated transport into the nucleus  Academic Article
• Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress  Academic Article
• Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes  Academic Article
• Depressed platelet status in an elderly patient with hemorrhagic stroke after thrombolysis for acute myocardial infarction  Academic Article
• Depression and stimulant dependence - neurobiology and pharmacotherapy  Academic Article
• Depression modulates pruritus perception - a study of pruritus in psoriasis, atopic-dermatitis, and chronic idiopathic urticaria  Academic Article
• Depression symptoms associated with cannabis dependence in an adolescent American Indian community sample  Academic Article
• Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway  Academic Article
• Deregulated cyclin e induces chromosome instability  Academic Article
• Deregulation of cyclin e in human cells interferes with prereplication complex assembly  Academic Article
• Deregulation of the c-myc and n-myc genes in transformed cells  Academic Article
• Derivation and characterization of a UCP1 reporter human ES cell line  Academic Article
• Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4  Academic Article
• Derivation and validation of a simple clinical bedside score (ATLAS) for Clostridium difficile infection which predicts response to therapy  Academic Article
• Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes  Academic Article
• Derivation of a retinoid x receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1h-indol-3-yl)methyl-4-trifluoromethylbenzene  Academic Article
• Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity  Academic Article
• Derivatives of 4-amino-3,6-disulfonato-1,8-naphthalimide inhibit reverse-transcriptase and suppress human and feline immunodeficiency virus expression in cultured-cells  Academic Article
• Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors  Academic Article
• Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease  Academic Article
• Dermatan sulfate and LMW heparin enhance the anticoagulant action of activated protein C  Academic Article
• Descending command systems for the initiation of locomotion in mammals  Academic Article
• Description of the data from the collaborative study on the genetics of alcoholism (coga) and single-nucleotide polymorphism genotyping for genetic analysis workshop 14  Academic Article
• Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a  Academic Article
• Desensitization of G protein-coupled receptors and neuronal functions  Academic Article
• Desensitization of the beta-adrenergic response in human brown adipocytes  Academic Article
• Desflurane increases brain tissue oxygenation and ph  Academic Article
• Design and characterization of a DNA-encoded, voltage-sensitive fluorescent protein  Academic Article
• Design and characterization of an active site selective caspase-3 transnitrosating agent  Academic Article
• Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus  Academic Article
• Design and characterization of stabilized derivatives of human cd4d12 and cd4d1  Academic Article
• Design and discovery of N-(2-Methyl-5 '-morpholino-6 '-((tetrahydro-2H-pyran-4-yl)oxy)- 3,3 '-bipyridin -5-yl)-3-(trifluoromethyl)benzamide (RAF709): a potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers  Academic Article
• Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors  Academic Article
• Design and evolution of new catalytic activity with an existing protein scaffold  Academic Article
• Design and simulation of a neutron source based on an electron linear accelerator for bnct of skin melanoma  Academic Article
• Design and structure of an engineered disulfide-stabilized influenza virus hemagglutinin trimer  Academic Article
• Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens  Academic Article
• Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors  Academic Article
• Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors  Academic Article
• Design and synthesis of 2-substituted-5-(4-trifluoromethylphenyl-sulphonamido)benzoxazole derivatives as human GST P1-1 inhibitors  Academic Article
• Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta  Academic Article
• Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives  Academic Article
• Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300  Academic Article
• Design and synthesis of a cell-permeable synthetic transcription factor mimic  Academic Article
• Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis  Academic Article
• Design and synthesis of conformationally constrained 3-(n-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (s1p) receptors  Academic Article
• Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives  Academic Article
• Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors  Academic Article
• Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase  Academic Article
• Design and synthesis of reboxetine analogs morpholine derivatives as selective norepinephrine reuptake inhibitors  Academic Article
• Design of RNAi hairpins for mutation-specific silencing of ataxin-7 and correction of a SCA7 phenotype  Academic Article
• Design of a Janus kinase 3 (JAK3) specific inhibitor 1-(2s,5R)-5-((7H-pyrrolo 2,3-d pyrimidin-4-yl)amino)-2-methylpiperidin-1 -y1)prop-2-en-1-one (PF-06651600) allowing for the interrogation of JAK3 signaling in humans  Academic Article
• Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching  Academic Article
• Design of a monomeric human glutathione transferase gstp1, a structurally stable but catalytically inactive protein  Academic Article
• Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant  Academic Article
• Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site  Academic Article
• Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy  Academic Article
• Design of peptide imaging agents for whole-body and intraoperative molecular imaging  Academic Article
• Design of polydactyl zinc-finger proteins for unique addressing within complex genomes  Academic Article
• Design of potent and proteolytically stable oxyntomodulin analogs  Academic Article
• Design of potent and selective 2-aminobenzimidazole-based p38 alpha MAP kinase inhibitors with excellent in vivo efficacy  Academic Article
• Design of specific mechanism-based inactivators of hepatic and adrenal microsomal cytochromes-P-450 responsible for progesterone 21-hydroxylation  Academic Article
• Design of the blockade of the glycoprotein iib/iiia receptor to avoid vascular occlusion (bravo) trial  Academic Article
• Design of two chimaeric human-rat class alpha glutathione transferases for probing the contribution of C-terminal segments of protein structure to the catalytic properties  Academic Article
• Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)  Academic Article
• Design, synthesis and activity of light deactivatable microRNA inhibitor  Academic Article
• Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins  Academic Article
• Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway  Academic Article
• Design, synthesis and biological evaluation of artemisinin derivatives containing fluorine atoms as anticancer agents  Academic Article
• Design, synthesis and biological evaluation of nonpeptide integrin antagonists  Academic Article
• Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors  Academic Article
• Design, synthesis and biological evaluation of novel pyrenyl derivatives as anticancer agents  Academic Article
• Design, synthesis and biological-activity of protaxols  Academic Article
• Design, synthesis and evaluation of 2,5-diketopiperazines as inhibitors of the MDM2-p53 interaction  Academic Article
• Design, synthesis and evaluation of a PLG tripeptidomimetic based on a pyridine scaffold  Academic Article
• Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors  Academic Article
• Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group  Academic Article
• Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus  Academic Article
• Design, synthesis, and biological activity of substrate competitive SMYD2 inhibitors  Academic Article
• Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway  Academic Article
• Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5)  Academic Article
• Design, synthesis, and biological evaluation of a biyouyanagin compound library  Academic Article
• Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors  Academic Article
• Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants  Academic Article
• Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase  Academic Article
• Design, synthesis, and biological properties of highly potent epothilone b analogues  Academic Article
• Design, synthesis, and evaluation of an α-helix mimetic library targeting protein-protein interactions  Academic Article
• Design, synthesis, and evaluation of novel 3,6-diaryl-4-aminoalkoxyquinolines as selective agonists of somatostatin receptor subtype 2  Academic Article
• Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors  Academic Article
• Design, synthesis, and evaluation of phe-gly mimetics: Heterocyclic building blocks for pseudopeptides  Academic Article
• Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors  Academic Article
• Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators  Academic Article
• Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists  Academic Article
• Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists  Academic Article
• Design, synthesis, and structure-activity-relationship of phenyl imidazoles as potent Smoothened antagonists  Academic Article
• Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions  Academic Article
• Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures  Academic Article
• Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of Jumonji domain-containing protein 2 histone demethylase inhibitors  Academic Article
• Designed enediynes - a new class of DNA-cleaving molecules with potent and selective anticancer activity  Academic Article
• Designed replacement of an internal hydration water molecule in bpti - structural and functional implications of a glycine-to-serine mutation  Academic Article
• Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses  Academic Article
• Designing a broad-spectrum integrative approach for cancer prevention and treatment  Academic Article
• Designing arenaviral vaccines  Academic Article
• Designing facial amphiphiles for the stabilization of integral membrane proteins  Academic Article
• Desipramine treatment of alcoholism  Academic Article
• Destabilization of Ca2+-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type  Academic Article
• Destruction of the locus coeruleus or the dorsal ne bundle does not alter the release of punished responding by ethanol and chlordiazepoxide  Academic Article
• Detailed characterization of the peptide binding specificity of five common Patr class I MHC molecules  Academic Article
• Detailed mechanisms of the inactivation of factor viiia by activated protein c in the presence of its cofactors, protein s and factor v  Academic Article
• Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis  Academic Article
• Detecting and quantifying multiple proteins in clinical samples in high-throughput using antibody microarrays  Academic Article
• Detecting expression of 5T4 in CTCs and tumor samples from NSCLC patients  Academic Article
• Detecting genetic variation in microarray expression data  Academic Article
• Detection and characterization of low abundance cellular proteins that specifically increase upon loss of the metastatic phenotype  Academic Article
• Detection and isolation of dendritic cells using Lewis X-functionalized magnetic nanoparticles  Academic Article
• Detection and partial characterization of an inhibitor of plasminogen activator in human platelets  Academic Article
• Detection and partial characterization of circulating immune-complexes with solid-phase anti-c3  Academic Article
• Detection and quantification of plasma amyloid-β by selected reaction monitoring mass spectrometry  Academic Article
• Detection and quantitation of cleaved and uncleaved high molecular weight kininogen in plasma by ligand blotting with radiolabeled plasma prekallikrein or factor XI  Academic Article
• Detection and typing of herpes simplex viruses by using recombinant immunoglobulin fragments produced in bacteria  Academic Article
• Detection of 2 apolipoprotein-b species (apobc and apobg) by a monoclonal-antibody  Academic Article
• Detection of a 140 KDA nucleolar protein with an anti-PCNA autoantibody  Academic Article
• Detection of a nucleolar 7-2 ribonucleoprotein and a cytoplasmic 8-2 ribonucleoprotein with autoantibodies from patients with scleroderma  Academic Article
• Detection of a ternary complex of nf-kappa b and i kappa b alpha with DNA provides insights into how i kappa b alpha removes nf-kappa b from transcription sites  Academic Article
• Detection of active kallikrein in induced blister fluids of hereditary angioedema patients  Academic Article
• Detection of alkynes via click chemistry with a brominated coumarin azide by simultaneous fluorescence and isotopic signatures in mass spectrometry  Academic Article
• Detection of antibodies against the four subtypes of ebola virus in sera from any species using a novel antibody-phage indicator assay  Academic Article
• Detection of apoptosis in cartilage in situ and in isolated chondrocytes  Academic Article
• Detection of autoantibodies to recombinant mitochondrial proteins in patients with primary biliary-cirrhosis  Academic Article
• Detection of borna disease virus (bdv) antibodies and bdv rna in psychiatric patients: Evidence for high sequence conservation of human blood-derived bdv rna  Academic Article
• Detection of borna disease virus antigen and rna in human autopsy brain samples from neuropsychiatric patients  Academic Article
• Detection of both type 1 and type 2 plasminogen activator inhibitors in human cells  Academic Article
• Detection of c-myc gene expression in nasopharyngeal carcinoma by nonradioactive in situ hybridization and immunohistochemistry  Academic Article
• Detection of carbohydrates and steroids by cation-enhanced nanostructure-initiator mass spectrometry (NIMS) for biofluid analysis and tissue imaging  Academic Article
• Detection of circulating immune-complexes in patients with glomerulonephritis  Academic Article
• Detection of complement activation by counterimmunoelectrophoresis (CIE)  Academic Article
• Detection of complete molar pregnancy by single-nucleotide polymorphism-based non-invasive prenatal testing  Academic Article
• Detection of cytomegalovirus nucleic-acid sequences in pancreas in type-2 diabetes  Academic Article
• Detection of ganglioside gd2 in tumor-tissues and sera of neuro-blastoma patients  Academic Article
• Detection of genetic-heterogeneity for complex quantitative phenotypes  Academic Article
• Detection of human cytomegalo-virus in peripheral-blood lymphocytes in a natural infection  Academic Article
• Detection of human cytomegalovirus in clinical specimens by DNA-DNA hybridization  Academic Article
• Detection of human α-L-Fucosidase by a quinone methide-generating probe: enhanced activities in response to Helicobacter pylori Infection  Academic Article
• Detection of immune complexes: Techniques and implications  Academic Article
• Detection of in vitro and in vivo cleavage of high molecular weight kininogen in human plasma by immunoblotting with monoclonal antibodies  Academic Article
• Detection of interleukin 1 beta but not tumor necrosis factor-alpha in cerebrospinal fluid of children with aseptic meningitis  Academic Article
• Detection of low molecular weight derivatives of cyclin e1 is a function of cyclin e1 protein levels in breast cancer  Academic Article
• Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing  Academic Article
• Detection of low-avidity CD4(+) T cells using recombinant artificial APC: following the antiovalbumin immune response  Academic Article
• Detection of miRNA in live cells by using templated RuII-catalyzed unmasking of a fluorophore  Academic Article
• Detection of minority resistance during early HIV-1 infection: natural variation and spurious detection rather than transmission and evolution of multiple viral variants  Academic Article
• Detection of protein S-sulfhydration by a tag-switch technique  Academic Article
• Detection of tissue kallikrein in the bronchoalveolar lavage fluid of asthmatic subjects  Academic Article
• Detection of triploid, molar, and vanishing twin pregnancies by a single-nucleotide polymorphism-based noninvasive prenatal test  Academic Article
• Determinants flanking the cd4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 r5 envelopes  Academic Article
• Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1  Academic Article
• Determinants of 2-year outcome after coronary angioplasty in patients with multivessel disease on the basis of comprehensive preprocedural evaluation - implications for patient selection  Academic Article
• Determinants of cytochrome P4502C8 substrate binding - structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid  Academic Article
• Determinants of human adipose tissue gene expression: Impact of diet, sex, metabolic status, and cis genetic regulation  Academic Article
• Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble cd4 and monoclonal antibodies  Academic Article
• Determinants of polyreactivity in a large panel of recombinant human antibodies from hiv-1 infection  Academic Article
• Determinants of sustained viral suppression in HIV-infected patients with self-reported poor adherence to antiretroviral therapy  Academic Article
• Determinants of the heme-CO vibrational modes in the H-NOX family  Academic Article
• Determinants of the need for early acute intervention in patients treated conservatively after thrombolytic therapy for acute myocardial-infarction  Academic Article
• Determinants of the use of coronary angiography and revascularization after thrombolysis for acute myocardial infarction  Academic Article
• Determinants of viral clearance and persistence during acute hepatitis C virus infection  Academic Article
• Determination of N-retinylidene-N-retinylethanolamine (A2E) levels in central and peripheral areas of human retinal pigment epithelium  Academic Article
• Determination of atomoxetine metabolites in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study  Academic Article
• Determination of clinical and demographic predictors of laboratory-confirmed influenza with subtype analysis  Academic Article
• Determination of enzymatic source of alanine aminotransferase activity in serum from dogs with liver injury  Academic Article
• Determination of functional and antigenic protein-C inhibitor and its complexes with activated protein-C in plasma by ELISA's  Academic Article
• Determination of matrix metalloproteinase activity using biotinylated gelatin  Academic Article
• Determination of meloxicam in human plasma using a hplc method with uv detection and its application to a pharmacokinetic study  Academic Article
• Determination of plasma protein-C inhibitor and of 2 activated protein-C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease  Academic Article
• Determination of structural models of the complex between the cytoplasmic domain of erythrocyte band 3 and ankyrin-R repeats 13-24  Academic Article
• Determination of the number of epsilon-amino groups available for conjugation of effector molecules to monoclonal-antibodies  Academic Article
• Determination of the von Willebrand's disease antigen (factor VIII-related antigen) in plasma by quantitative immunoelectrophoresis  Academic Article
• Determination of unbound antiretroviral drug concentrations by a modified ultrafiltration method reveals high variability in the free fraction  Academic Article
• Determining conserved metabolic biomarkers from a million database queries  Academic Article
• Determining target engagement in living systems  Academic Article
• Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases  Academic Article
• Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione  Academic Article
• Detoxification of styrene oxide by human liver glutathione transferase  Academic Article
• Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface  Academic Article
• Developing a vaccine against multiple psychoactive targets: a case study of heroin  Academic Article
• Developing basic and clinical research on von Willebrand factor and von Willebrand disease  Academic Article
• Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair  Academic Article
• Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction  Academic Article
• Development and mechanism of γ-secretase modulators for Alzheimer's disease  Academic Article
• Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis  Academic Article
• Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15  Academic Article
• Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor  Academic Article
• Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4  Academic Article
• Development and validation of a broad scheme for prediction of HLA class II restricted T cell epitopes  Academic Article
• Development and validation of decision rules to guide frequency of monitoring CD4 cell count in HIV-1 infection before starting antiretroviral therap  Academic Article
• Development of 5N-bicalutamide, a high-affinity reversible covalent antiandrogen  Academic Article
• Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors  Academic Article
• Development of GlcNAc-Inspired Iminocyclitiols as Potent and Selective N-Acetyl-beta-Hexosaminidase Inhibitors  Academic Article
• Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity  Academic Article
• Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients  Academic Article
• Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors  Academic Article
• Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3)  Academic Article
• Development of a highly potent, novel M(5) positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)pipe ridine-4-carboxamide (ML380)  Academic Article
• Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection  Academic Article
• Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans  Academic Article
• Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates  Academic Article
• Development of a multi-institutional cohort to facilitate cardiovascular disease biomarker validation using existing biorepository samples linked to electronic health records  Academic Article
• Development of a novel vaccine containing binary toxin for the prevention of clostridium difficile disease with enhanced efficacy against NAP1 strains  Academic Article
• Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screening  Academic Article
• Development of a simultaneous analytical method for selected anorectics, methamphetamine, mdma, and their metabolites in hair using lc-ms/ms to prove anorectics abuse  Academic Article
• Development of activity-based probes for imaging Human α-l-Fucosidases in cells  Academic Article
• Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead  Academic Article
• Development of an HTS-compatible assay for discovery of ROR alpha modulators using AlphaScreen (r) technology  Academic Article
• Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology  Academic Article
• Development of an HTS-compatible assay for the discovery of Ulk1 inhibitors  Academic Article
• Development of an intact cell reporter gene beta-lactamase assay for g protein-coupled receptors for high-throughput screening  Academic Article
• Development of anti-CD74 antibody-drug conjugates to target glucocorticoids to immune cells  Academic Article
• Development of antibody surrogates for the treatment of cancers and autoimmune disease  Academic Article
• Development of antigen-specific helper T cell responses in vivo: antigen-specific Th cell subsets  Academic Article
• Development of bioorthogonal reactions and their applications in bioconjugation  Academic Article
• Development of c5a receptor antagonists - differential loss of functional-responses  Academic Article
• Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris  Academic Article
• Development of clickable active site-directed photoaffinity probes for γ-secretase  Academic Article
• Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis  Academic Article