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Friedreich Ataxia

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  • A gene expression phenotype in lymphocytes from Friedreich ataxia patients  Academic Article
  • Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing  Academic Article
  • DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia  Academic Article
  • Epigenetic therapy for Friedreich ataxia  Academic Article
  • Evaluation of histone deacetylase inhibitors as therapeutics for neurodegenerative diseases  Academic Article
  • Friedreich's ataxia induced pluripotent stem cells model intergenerational GAA.TTC triplet repeat instability  Academic Article
  • HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model  Academic Article
  • Histone deacetylase inhibitors reverse gene silencing in friedreich's ataxia  Academic Article
  • Long intronic GAATTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia  Academic Article
  • Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class i histone deacetylases  Academic Article
  • Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model  Academic Article
  • Quantitative proteomic analysis identifies targets and pathways of a 2-aminobenzamide HDAC inhibitor in Friedreich's ataxia patient iPSC-derived neural stem cells  Academic Article
  • Rationale for the development of 2-aminobenzamide histone deacetylase inhibitors as therapeutics for Friedreich ataxia  Academic Article
  • Role of mismatch repair enzymes in GAA.TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells  Academic Article
  • Small molecules affecting transcription in Friedreich ataxia  Academic Article
  • Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model  Academic Article

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