subject area of

• -Amino acid substitution of peptide-mediated NF-κB suppression in mdx mice preserves therapeutic benefit in skeletal muscle, but causes kidney toxicity  Academic Article
• 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency  Academic Article
• 5-HT(7) receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern  Academic Article
• 5-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity  Academic Article
• 7-nitroindazole, nitric oxide synthase inhibitor, attenuates physical dependence on butorphanol in rat  Academic Article
• A Bellagio consensus. Children's Vaccine Initiative Ad Hoc Committe on an investment strategy for measles control  Academic Article
• A blueprint for HIV vaccine discovery  Academic Article
• A broadly neutralizing human monoclonal antibody exhibits in vivo efficacy against both human metapneumovirus and respiratory syncytial virus  Academic Article
• A candidate circuit approach to investigating autism  Academic Article
• A cellular mechanism for dendritic spine loss in the pilocarpine model of status epilepticus  Academic Article
• A chimeric mouse model of Gaucher disease  Academic Article
• A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models  Academic Article
• A critical role for the sphingosine analog aal-r in dampening the cytokine response during influenza virus infection  Academic Article
• A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics  Academic Article
• A dystroglycan mutation associated with limb-girdle muscular dystrophy  Academic Article
• A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function  Academic Article
• A genetic analysis of lupus  Academic Article
• A genetically humanized mouse model for hepatitis C virus infection  Academic Article
• A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis  Academic Article
• A human recombinant monoclonal antibody to cocaine: preparation, characterization and behavioral studies  Academic Article
• A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis  Academic Article
• A liver-selective LXR inverse agonist that suppresses hepatic steatosis  Academic Article
• A model for familial exudative vitreoretinopathy caused by LPR5 mutations  Academic Article
• A mouse model for nonsyndromic deafness (dfnb12) links hearing loss to defects in tip links of mechanosensory hair cells  Academic Article
• A mouse model of accelerated liver aging caused by a defect in DNA repair  Academic Article
• A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice  Academic Article
• A multifunctional bispecific antibody protects against Pseudomonas aeruginosa  Academic Article
• A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response  Academic Article
• A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis  Academic Article
• A novel generation of heparan sulfate mimetics for the treatment of prion diseases  Academic Article
• A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease  Academic Article
• A novel synthetic bipartite carrier protein for developing glycotope-based vaccines  Academic Article
• A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects  Academic Article
• A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice  Academic Article
• A plaque-specific antibody clears existing beta-amyloid plaques in Alzheimer's disease mice  Academic Article
• A putative bacterial ABC transporter circumvents the essentiality of signal peptidase  Academic Article
• A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome  Academic Article
• A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition  Academic Article
• A stem cell-based approach to cartilage repair  Academic Article
• A synthetic tlr4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease  Academic Article
• A transgenic mouse model for measles virus infection of the brain  Academic Article
• A transgenic mouse model of the chronic hepatitis B surface antigen carrier state  Academic Article
• A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates  Academic Article
• A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes  Academic Article
• ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC  Academic Article
• Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss  Academic Article
• Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model  Academic Article
• Accelerated aging of intervertebral discs in a mouse model of progeria  Academic Article
• Accelerating next-generation vaccine development for global disease prevention  Academic Article
• Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects  Academic Article
• Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo  Academic Article
• Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1  Academic Article
• Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells  Academic Article
• Activation of HIPK2 promotes ER stress-mediated neurodegeneration in amyotrophic lateral sclerosis  Academic Article
• Activation of brain NOP receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat  Academic Article
• Activation of lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury  Academic Article
• Activation of p38α in T cells regulates the intestinal host defense against attaching and effacing bacterial infections  Academic Article
• Activation of the liver x receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy  Academic Article
• Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: a potential therapeutic target  Academic Article
• Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats  Academic Article
• Activity of hoechst 33258 against Pneumocystis carinii f. sp muris, Candida albicans, and Candida dubliniensis  Academic Article
• Acute immunologic arthritis in rabbits  Academic Article
• Adaptation of energy metabolism in breast cancer brain metastases  Academic Article
• Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-- Jakob disease: implications for human health  Academic Article
• Adaptation, allometry, and hypertension  Academic Article
• Additive effect of stress and drug cues on reinstatement of ethanol seeking: Exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms  Academic Article
• Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway  Academic Article
• Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary-artery model  Academic Article
• Administration of recombinant p-selectin glycoprotein ligand fc fusion protein suppresses inflammation and neointimal formation in zucker diabetic rat model  Academic Article
• Adoptive transfer of human lymphoid cells to severely immunodeficient mice: models for normal human immune function, autoimmunity, lymphomagenesis, and AIDS  Academic Article
• Adult CST-null mice maintain an increased number of oligodendrocytes  Academic Article
• Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees  Academic Article
• Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state  Academic Article
• Alcohol-related genes: Contributions from studies with genetically engineered mice  Academic Article
• Alcoholism: Allostasis and beyond  Academic Article
• Alteration of intracerebral cytokine production in mice infected with herpes-simplex virus type-1 and type-2  Academic Article
• Alteration of methamphetamine-induced stereotypic behaviour in transgenic mice expressing hiv-1 envelope protein gp120  Academic Article
• Alterations in spinal cord metabolism during treatment of neuropathic pain  Academic Article
• Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor  Academic Article
• Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model  Academic Article
• Amelioration of chronic murine colitis by peptide-mediated transduction of the I kappa B kinase inhibitor NEMO binding domain peptide  Academic Article
• Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma  Academic Article
• Aminostyrylbenzofuran directly reduces oligomeric amyloid-β and reverses cognitive deficits in Alzheimer transgenic mice  Academic Article
• Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD  Academic Article
• Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: A possible model for senile systemic amyloidosis  Academic Article
• Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model  Academic Article
• An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model  Academic Article
• An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages  Academic Article
• An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy  Academic Article
• An animal-model to study serum immunoglobulin response to infection by Yersinia-entercocolitica  Academic Article
• An autosomal recessive gene that delays expression of lupus in bxsb mice  Academic Article
• An epigenetic blockade of cognitive functions in the neurodegenerating brain  Academic Article
• An evaluation of the development of experimental membranous nephropathy  Academic Article
• An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints  Academic Article
• Analysis of t-cell function in autoimmune murine strains - defects in production of and responsiveness to interleukin-2  Academic Article
• Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo  Academic Article
• Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase  Academic Article
• Androgen receptor splice variants determine taxane sensitivity in prostate cancer  Academic Article
• Animal model of respiratory syncytial virus: CD8(+) T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy  Academic Article
• Animal models for retrovirus-induced immunodeficiency disease  Academic Article
• Animal models in dengue  Academic Article
• Animal models of craving for ethanol  Academic Article
• Animal models of craving: a roundtable discussion  Academic Article
• Animal models of human amyloidoses: Are transgenic mice worth the time and trouble?  Academic Article
• Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology  Academic Article
• Animal models used to examine the role of the environment in the development of autoimmune disease: Findings from an NIEHS Expert Panel Workshop  Academic Article
• Animal-models of drug craving  Academic Article
• Anti-cd11b antibody prevents immunopathologic changes in viable moth-eaten bone-marrow chimeric mice  Academic Article
• Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones  Academic Article
• Anti-inflammatory activity of superoxide dismutase obtained from Debaryomyces hansenii on type II collagen induced arthritis in rats  Academic Article
• Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke  Academic Article
• Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma  Academic Article
• Antibodies against cd14 protect primates from endotoxin-induced shock  Academic Article
• Antibody SPC-54 provides acute in vivo blockage of the murine protein C system  Academic Article
• Antibody neutralization-resistant primary isolates of human immunodeficiency virus type 1  Academic Article
• Antibody responses to envelope glycoproteins in HIV-1 infection  Academic Article
• Antibody-il-12 fusion proteins are effective in scid mouse models of prostate and colon carcinoma metastases  Academic Article
• Anticonvulsant activity of a nonpeptide galanin receptor agonist  Academic Article
• Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation  Academic Article
• Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress  Academic Article
• Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978  Academic Article
• Antithrombotic activity of protein S infused without activated protein C in a baboon thrombosis model  Academic Article
• Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models  Academic Article
• Application of genomics to toxicology research  Academic Article
• Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor  Academic Article
• Arenavirus genetic diversity and its biological implications  Academic Article
• Arenavirus genome rearrangement for the development of live attenuated vaccines  Academic Article
• Arginine 54 and tyrosine 118 residues of αA-crystallin are crucial for lens formation and transparency  Academic Article
• Association of cartilage-specific deletion of peroxisome proliferator-activated receptor gamma with abnormal endochondral ossification and impaired cartilage growth and development in a murine model  Academic Article
• Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina  Academic Article
• Attenuation of allergic contact dermatitis through the endocannabinoid system  Academic Article
• Attenuation of cue-induced heroin-seeking behavior by cannabinoid CB(1) antagonist infusions into the nucleus accumbens core and prefrontal cortex, but not basolateral amygdala  Academic Article
• Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: Involvement of regulatory T cells  Academic Article
• Autoantibodies to gpi in rheumatoid arthritis: Linkage between an animal model and human disease  Academic Article
• Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients  Academic Article
• Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice  Academic Article
• Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation  Academic Article
• B-cell-tropic interleukins in murine systemic lupus-erythematosus (sle)-1  Academic Article
• BAG1 over-expression in brain protects against stroke  Academic Article
• BCL-2 in prostate cancer: A minireview  Academic Article
• BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice  Academic Article
• Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid.  Academic Article
• Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy  Academic Article
• Basic science of intra-articular fractures and posttraumatic osteoarthritis  Academic Article
• Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells  Academic Article
• Behavioral, biological, and chemical perspectives on targeting crf1 receptor antagonists to treat alcoholism  Academic Article
• Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): Efficacy in an animal model for schizophrenia  Academic Article
• Benzoxazolinone aryl sulfonamides as potent, selective Na(v)1.7 inhibitors with in vivo efficacy in a preclinical pain model  Academic Article
• Beta 1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex  Academic Article
• Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis  Academic Article
• Binding of soluble immune complexes to human lymphoblastoid cells. Ii. Use of raji cells to detect circulating immune complexes in animal and human sera  Academic Article
• Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection  Academic Article
• Biology and pathogenesis of lymphocytic choriomeningitis virus infection  Academic Article
• Biphasic alterations in serotonin-1B (5-HT1B) receptor function during abstinence from extended cocaine self-administration  Academic Article
• Blockade of hypocretin receptor-1 preferentially prevents cocaine seeking: comparison with natural reward seeking  Academic Article
• Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection  Academic Article
• Blockade of the platelet p2y(12) receptor by ar-c69931mx sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis model  Academic Article
• Bornavirus and the brain  Academic Article
• Brain disease model of addiction: why is it so controversial?  Academic Article
• Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury  Academic Article
• Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice  Academic Article
• Bronchoalveolar lavage with KL4-Surfactant in models of meconium aspiration syndrome  Academic Article
• CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120  Academic Article
• CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection.  Academic Article
• Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain  Academic Article
• Can a single subunit yeast nadh dehydrogenase (ndi1) remedy diseases caused by respiratory complex i defects?  Academic Article
• Cancer-specific mutations in PIK3CA are oncogenic in vivo  Academic Article
• Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: An expanded convergent functional genomics approach  Academic Article
• Carboxyfullerene neuroprotection postinjury in Parkinsonian nonhuman primates  Academic Article
• Cellular and behavioral interactions of gabapentin with alcohol dependence  Academic Article
• Cellular events associated with immunogenesis of anti-erythrocyte autoantibody responses of nzb mice  Academic Article
• Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics  Academic Article
• Central nervous system (cns)-resident natural killer cells suppress th17 responses and cns autoimmune pathology  Academic Article
• Central nervous system infection with Borna disease virus causes kynurenine pathway dysregulation and neurotoxic quinolinic acid production  Academic Article
• Centrally administered urocortin 2 decreases gorging on high-fat diet in both diet-induced obesity-prone and -resistant rats  Academic Article
• Changes in locomotor response to beta-endorphin microinfusion during and after opiate abstinence syndrome - a proposal for a model of the onset of mania  Academic Article
• Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse  Academic Article
• Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.  Academic Article
• Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin  Academic Article
• Characterization of a side population of astrocytoma cells in response to temozolomide  Academic Article
• Characterization of cytokine and inos mrna expression in situ during the course of experimental autoimmune myocarditis in rats  Academic Article
• Characterization of mouse mutants with abnormal RPE cells  Academic Article
• Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain  Academic Article
• Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels  Academic Article
• Chemical probes of endocannabinoid metabolism  Academic Article
• Chemoproteomic profiling of host and pathogen enzymes active in cholera  Academic Article
• Chick embryo chorioallantoic membrane models to quantify angiogenesis induced by inflammatory and tumor cells or purified effector molecules  Academic Article
• Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test  Academic Article
• Chronic alcohol consumption generates a vulnerable immune environment during early SIV infection in rhesus macaques  Academic Article
• Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking  Academic Article
• Chronic periadolescent alcohol consumption produces persistent cognitive deficits in rhesus macaques  Academic Article
• Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure  Academic Article
• Chronic wasting disease of deer and elk in transgenic mice: Oral transmission and pathobiology  Academic Article
• Chronic wheel running reduces maladaptive patterns of methamphetamine intake: Regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase  Academic Article
• Circadian physiology of metabolism  Academic Article
• Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints  Academic Article
• Clinical features of bacterial vaginosis in a murine model of vaginal infection with Gardnerella vaginalis  Academic Article
• Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors  Academic Article
• Combination angiostatic therapies: targeting multiple angiogenic pathways  Academic Article
• Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma  Academic Article
• Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models  Academic Article
• Common genetic mechanisms of blood pressure elevation in two independent rodent models of human essential hypertension  Academic Article
• Comparative analysis of metastasis variants derived from human prostate carcinoma cells: roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion  Academic Article
• Comparative immunological analysis of several murine strains with autoimmune manifestations  Academic Article
• Comparison of mice with accelerated aging caused by distinct mechanisms  Academic Article
• Completion of the entire hepatitis C virus life cycle in genetically humanized mice  Academic Article
• Complex I inhibition in the visual pathway induces disorganization of the node of Ranvier  Academic Article
• Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors  Academic Article
• Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems  Academic Article
• Conditioned withdrawal drives heroin consumption and decreases reward sensitivity  Academic Article
• Connexin mediated cataract prevention in mice  Academic Article
• Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis  Academic Article
• Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility  Academic Article
• Contribution of spinal 5-ht1a and 5-ht7 receptors to locomotor-like movement induced by 8-oh-dpat in spinal cord-transected mice  Academic Article
• Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors  Academic Article
• Convergent functional genomic studies of omega-3 fatty acids in stress reactivity, bipolar disorder and alcoholism  Academic Article
• Convergent functional genomics of anxiety disorders: Translational identification of genes, biomarkers, pathways and mechanisms  Academic Article
• Convergent functional genomics of bipolar disorder: From animal model pharmacogenomics to human genetics and biomarkers  Academic Article
• Convergent functional genomics of psychiatric disorders  Academic Article
• Convergent functional genomics of schizophrenia: From comprehensive understanding to genetic risk prediction  Academic Article
• Convergent functional genomics: a Bayesian candidate gene identification approach for complex disorders  Academic Article
• Convergent integration of animal model and human studies of bipolar disorder (manic-depressive illness)  Academic Article
• Conversion of human fibroblasts into functional cardiomyocytes by small molecules  Academic Article
• Conversion of human fibroblasts to functional endothelial cells by defined factors  Academic Article
• Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model  Academic Article
• Cortical neuronal cytoskeletal changes associated with fiv infection  Academic Article
• Corticotropin-releasing factor (CRF) and alpha 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats  Academic Article
• Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats  Academic Article
• Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection  Academic Article
• Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal CNS  Academic Article
• Critical role of transmethylation in TLR signaling and systemic lupus erythematosus  Academic Article
• Cross-reactive and potent neutralizing antibody responses in human survivors of natural Ebolavirus infection  Academic Article
• Crystallin gamma B-I4F mutant protein binds to alpha-crystallin and affects lens transparency  Academic Article
• Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide  Academic Article
• Cytoplasmic extracts from adipose tissue stromal cells alleviates secondary damage by modulating apoptosis and promotes functional recovery following spinal cord injury  Academic Article
• Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa-induced lung injury in mice  Academic Article
• DISC1 regulates trafficking and processing of APP and Aβ generation  Academic Article
• DNA vaccination against vegf receptor 2 reduces atherosclerosis in ldl receptor-deficient mice  Academic Article
• DNA vaccination can break immunological tolerance to prp in wild-type mice and attenuates prion disease after intracerebral challenge  Academic Article
• Daring to learn from humanized mice  Academic Article
• Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice  Academic Article
• Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders  Academic Article
• Defects in skin γδ T cell function contribute to delayed wound repair in rapamycin-treated mice  Academic Article
• Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances  Academic Article
• Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model  Academic Article
• Deficiency of the cyclin kinase inhibitor P21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoirnmunity  Academic Article
• Defining parameters for successful immunocytotherapy of persistent viral infection  Academic Article
• Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis  Academic Article
• Deletions linked to TP53 loss drive cancer through p53-independent mechanisms  Academic Article
• Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin  Academic Article
• Dense nuclear cataract caused by the γB-crystallin S11R point mutation  Academic Article
• Dentate gyrus volume is reduced before onset of plaque formation in pdapp mice: A magnetic resonance microscopy and stereologic analysis  Academic Article
• Dependence-induced alcohol drinking by alcohol-preferring (p) rats and outbred wistar rats  Academic Article
• Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease  Academic Article
• Design, synthesis and SAR of novel glucokinase activators  Academic Article
• Determination of enzymatic source of alanine aminotransferase activity in serum from dogs with liver injury  Academic Article
• Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection  Academic Article
• Development of a novel vaccine containing binary toxin for the prevention of clostridium difficile disease with enhanced efficacy against NAP1 strains  Academic Article
• Development of approaches to improve cell survival in myoblast transfer therapy  Academic Article
• Development of live-attenuated arenavirus vaccines based on codon deoptimization  Academic Article
• Diabetes insipidus in mice with a mutation in aquaporin-2  Academic Article
• Didehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic mice  Academic Article
• Different mechanisms of increased luminal stenosis after arterial injury in mice deficient for urokinase- or tissue-type plasminogen activator  Academic Article
• Differential effects of acute alcohol on prepulse inhibition and event-related potentials in adolescent and adult Wistar rats  Academic Article
• Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy  Academic Article
• Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia.  Academic Article
• Differential role of melanocortin receptor subtypes in cachexia  Academic Article
• Diffuse lung disease in children: summary of a scientific conference  Academic Article
• Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model  Academic Article
• Discovering disease-associated enzymes by proteome reactivity profiling  Academic Article
• Discovery and optimization of a series of pyrimidine-based phosphodiesterase 10A (PDE10A) inhibitors through fragment screening, structure-based design, and parallel synthesis  Academic Article
• Discovery of 5-aryl-1,3-dihydro-2H-imidazo 4,5-b pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis  Academic Article
• Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition  Academic Article
• Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements  Academic Article
• Discovery of novel drugs for promising targets  Academic Article
• Discovery of potent and bioavailable GSK-3β inhibitors  Academic Article
• Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model  Academic Article
• Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na(v)1.7 inhibitors with pain efficacy in mice  Academic Article
• Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis  Academic Article
• Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal  Academic Article
• Distinct antithrombotic consequences of platelet glycoprotein Ibα and VI deficiency in a mouse model of arterial thrombosis  Academic Article
• Distinct patterns of neural activation associated with ethanol seeking: Effects of naltrexone  Academic Article
• Divergent anatomical pattern of d-1 and d-3 binding and dopamine- and cyclic amp-regulated phosphoprotein of 32 kda mrna expression in the roman rat strains: Implications for drug addiction  Academic Article
• Dna immunization and central nervous system viral infection  Academic Article
• Dominant cataracts result from incongruous mixing of wild-type lens connexins  Academic Article
• Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy  Academic Article
• Dopamine d2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats  Academic Article
• Dorsal as well as ventral striatal lesions affect levels of intravenous cocaine and morphine self-administration in rats  Academic Article
• Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats  Academic Article
• Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils  Academic Article
• Dramatic decreases in brain reward function during nicotine withdrawal  Academic Article
• Drug dependence: Stress and dysregulation of brain reward pathways  Academic Article
• Drug target validation: lethal infection blocked by inducible peptide  Academic Article
• Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis  Academic Article
• Dysfunctional gamma delta t cells contribute to impaired keratinocyte homeostasis in mouse models of obesity  Academic Article
• EEG and ERP profiles in the high alcohol preferring (HAP) and low alcohol preferring (LAP) mice: Relationship to ethanol preference  Academic Article
• EPHA2 is associated with age-related cortical cataract in mice and humans  Academic Article
• EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques  Academic Article
• ERK regulation in chronic ethanol exposure and withdrawal  Academic Article
• Early dysfunction of central 5-HT system in a murine model of bovine spongiform encephalopathy  Academic Article
• Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats  Academic Article
• Early spontaneous metastasis in the human epidermoid carcinoma hep3-chick embryo model - contribution of incidental colonization  Academic Article
• Early-onset behavioral and synaptic deficits in a mouse model of alzheimer's disease  Academic Article
• EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin  Academic Article
• Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease  Academic Article
• Editorial overview: Viral pathogenesis  Academic Article
• Effect of amrinone on tumor necrosis factor production in endotoxic shock  Academic Article
• Effect of aripiprazole, a partial dopamine d-2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration  Academic Article
• Effect of chronic hypoxia on detoxication enzymes in rat liver  Academic Article
• Effect of complement depletion on experimental tissue injury  Academic Article
• Effect of experimental cerebral infarction in rat-brain on catecholamines and behavior  Academic Article
• Effect of hyperhomocysteinemia on protein C activation and activity  Academic Article
• Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus  Academic Article
• Effect of sigma(1) receptor antagonism on ethanol and natural reward seeking  Academic Article
• Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen  Academic Article
• Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy  Academic Article
• Effective therapy of the LP-BM5 murine retrovirus-induced lymphoproliferative immunodeficiency disease with diethyldithiocarbamate  Academic Article
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• The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice  Academic Article
• The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates  Academic Article
• The New Zealand black mouse as a model for the development and progression of chronic lymphocytic leukemia  Academic Article
• The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans  Academic Article
• The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids  Academic Article
• The anxiolytic-like effects of the neurosteroid allopregnanolone: Interactions with gaba(a) receptors  Academic Article
• The bicarbonate transporter is essential for bacillus anthracis lethality  Academic Article
• The biology of metastasis to a sanctuary site  Academic Article
• The cell tropism of human immunodeficiency virus type 1 determines the kinetics of plasma viremia in SCID mice reconstituted with human peripheral blood leukocytes  Academic Article
• The chimpanzee model for hepatitis B virus infection  Academic Article
• The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr  Academic Article
• The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs  Academic Article
• The effect of complement depletion on bacterial lipopolysaccharide (LPS)-induced hemodynamic and hematologic changes in the Rhesus monkey  Academic Article
• The effect of glycosaminoglycan loss on chondrocyte viability: a study on porcine cartilage explants  Academic Article
• The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus  Academic Article
• The effect of the phytoestrogen coumestrol on the nzb/w f1 murine model of systemic lupus  Academic Article
• The effects of pharmacological inhibition of histone deacetylase 3 (HDAC3) in Huntington's disease mice  Academic Article
• The first human epitope map of the alphaviral E1 and E2 proteins reveals a new E2 epitope with significant virus neutralizing activity  Academic Article
• The genetics of hypertension  Academic Article
• The glycoprotein precursor gene of Junin virus determines the virulence of the Romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever  Academic Article
• The half-life of hepatitis B virions  Academic Article
• The high degree of sequence plasticity of the arenavirus noncoding intergenic region (IGR) enables the use of a nonviral universal synthetic IGR to attenuate arenaviruses  Academic Article
• The human genome: genetic testing and animal models  Academic Article
• The human retinal degeneration slow (rds) gene - chromosome assignment and structure of the messenger-rna  Academic Article
• The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes  Academic Article
• The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity  Academic Article
• The lysophosphatidic acid receptor lpa(1) promotes epithelial cell apoptosis after lung injury  Academic Article
• The marshall r. Urist young investigator award. Orthopaedic applications of gene therapy. From concept to clinic  Academic Article
• The maternal immune response to fetal platelet GPIb alpha causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies  Academic Article
• The mechanism of molecular redundancy in autoimmune inflammation in the context of CD44 deficiency  Academic Article
• The metabolism of glycosaminoglycans is impaired in prion diseases  Academic Article
• The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity  Academic Article
• The neurobiology of addiction: A neuroadaptational view relevant for diagnosis  Academic Article
• The neurobiology, clinical efficacy and safety of acamprosate in the treatment of alcohol dependence  Academic Article
• The new paradigm of T-cell homeostatic proliferation-induced autoimmunity  Academic Article
• The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme  Academic Article
• The opioid peptides enkephalin and beta-endorphin in alcohol dependence  Academic Article
• The origin and function of soluble cd14 in experimental bacterial meningitis  Academic Article
• The response to burn injury in mice with human hematolymphoid systems  Academic Article
• The restenosis paradigm revisited - an alternative proposal for cellular mechanisms  Academic Article
• The role of complement in experimental disease models  Academic Article
• The role of craving in alcohol use, dependence, and treatment  Academic Article
• The role of nitric oxide in articular cartilage damage  Academic Article
• The role of platelet adhesion receptor GPIb alpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis  Academic Article
• The selective monoacylglycerol lipase inhibitor MJN110 produces opioid-sparing effects in a mouse neuropathic pain model  Academic Article
• The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 attenuates a scopolamine-induced deficit in a novel rodent attention task  Academic Article
• The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking  Academic Article
• The skinny on brain-derived neurotrophic factor: evidence from animal models to GWAS  Academic Article
• The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism  Academic Article
• The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice  Academic Article
• The temporal expression patterns of fibronectin and its receptors-α5β1 and αvβ3 integrins on blood vessels after cerebral ischemia  Academic Article
• The toll of toll-like receptors, especially toll-like receptor 2, on murine atherosclerosis  Academic Article
• The transition from controlled to compulsive drug use is associated with a loss of sensitization  Academic Article
• Theoretical frameworks and mechanistic aspects of alcohol addiction: Alcohol addiction as a reward deficit disorder  Academic Article
• Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models  Academic Article
• Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment  Academic Article
• Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models  Academic Article
• Therapeutic potential of new antiinflammatory drugs  Academic Article
• Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease  Academic Article
• Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption  Academic Article
• Tissue factor contributes to microvascular defects after focal cerebral ischemia  Academic Article
• Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model - studies in tPA-deficient mice and wild-type mice on a matched genetic background  Academic Article
• Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice  Academic Article
• Tissue-specific regulation of p38α-mediated inflammation in Con A-induced acute liver damage  Academic Article
• Tlr2 in murine atherosclerosis  Academic Article
• Tlr4/md-2 monoclonal antibody therapy affords protection in experimental models of septic shock  Academic Article
• Tlrs and ifns: Critical pieces of the autoimmunity puzzle  Academic Article
• Tolerance induction by the blockade of CD40/CD154 interaction in pemphigus vulgaris mouse model  Academic Article
• Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection  Academic Article
• Toll-like receptors and atherosclerosis - key contributors in disease and health?  Academic Article
• Toll-like receptors in atherosclerosis  Academic Article
• Toward an aids vaccine  Academic Article
• Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease  Academic Article
• Transdifferentiation of glioblastoma cells into vascular endothelial cells  Academic Article
• Transfer of a functional human immune system to mice with severe combined immunodeficiency  Academic Article
• Transfer of human chronic lymphocytic leukemia to mice with severe combined immune deficiency  Academic Article
• Transfer of pro alpha 2(i) cdna into cells of a murine model of human osteogenesis imperfecta restores synthesis of type i collagen comprised of alpha 1(i) and alpha 2(i) heterotrimers in vitro and in vivo  Academic Article
• Transgenic mice expressing human hla and cd8 molecules generate hla-restricted measles virus cytotoxic t lymphocytes of the same specificity as humans with natural measles virus infection  Academic Article
• Transmission of prions  Academic Article
• Transplantation of virally transduced cells into the dermis of immunocompetent and immunodeficient (SCID) mice to determine gene expression profile and differential donor cell survival  Academic Article
• Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?  Academic Article
• Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of a beta toxicity  Academic Article
• Transthyretin: The servant of many masters  Academic Article
• Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity  Academic Article
• Treatment of mice with human monoclonal antibody 24 h after lethal aerosol challenge with virulent Venezuelan equine encephalitis virus prevents disease but not infection  Academic Article
• Treatment with lxr agonists after focal cerebral ischemia prevents brain damage  Academic Article
• Tubulointerstitial nephritis induced in the brown norway rat with chaotropically solubilized bovine tubular basement-membrane - the model and the humoral and cellular-responses  Academic Article
• Tumor necrosis factor in mediating experimental hemophilus-influenzae type-b meningitis  Academic Article
• Tumor-targeted il-2 amplifies t cell-mediated immune response induced by gene therapy with single-chain il-12  Academic Article
• Two msbb genes encoding maximal acylation of lipid a are required for invasive shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium  Academic Article
• Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model  Academic Article
• Type I and type II interferon coordinately regulate suppressive dendritic cell fate and function during viral persistence  Academic Article
• Type i interferon during viral infections: Multiple triggers for a multifunctional mediator  Academic Article
• Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris  Academic Article
• Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model  Academic Article
• Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations  Academic Article
• Unravelling the association of partial T-cell immunodeficiency and immune dysregulation  Academic Article
• Upregulation of fibronectin and the α5β1 and αvβ3 integrins on blood vessels within the cerebral ischemic penumbra  Academic Article
• Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior  Academic Article
• Use of a novel mouse genotype to model acute benzodiazepine withdrawal  Academic Article
• Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model  Academic Article
• Using transgenic mouse models to dissect the pathogenesis of virus-induced autoimmune disorders of the islets of langerhans and the central nervous system  Academic Article
• Utility of genetically modified mice for understanding the neurobiology of substance use disorders  Academic Article
• VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice  Academic Article
• VBP15, a novel dissociative steroid compound, reduces NFκB-induced expression of inflammatory cytokines in vitro and symptoms of murine trinitrobenzene sulfonic acid-induced colitis  Academic Article
• Vaccination against tie2 reduces atherosclerosis  Academic Article
• Vascular remodeling underlies rebleeding in hemophilic arthropathy  Academic Article
• Viral persistence: Parameters, mechanisms and future predictions  Academic Article
• Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis  Academic Article
• Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and multiple sclerosis  Academic Article
• Virus-induced diabetes in a transgenic model: Role of cross-reacting viruses and quantitation of effector t cells needed to cause disease  Academic Article
• Volumetric evaluation of the ischemic lesion size with serial mri in a transient mcao model of the rat: Comparison of dwi and t1wi  Academic Article
• Whither or wither microbicides?  Academic Article
• Whole animal section insitu hybridization and protein blotting - new tools in molecular analysis of animal-models for human-disease  Academic Article
• Why are some amyloidoses systemic? Does hepatic "chaperoning at a distance" prevent cardiac deposition in a transgenic model of human senile systemic (transthyretin) amyloidosis?  Academic Article
• X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C  Academic Article
• Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone BXSB mice  Academic Article
• Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice  Academic Article
• [HIV glycoprotein 120: possible etiological agent of AIDS-associated dementia] [Article in Spanish]  Academic Article
• betaCaMKII in lateral habenula mediates core symptoms of depression  Academic Article
• gp120 and neurotoxicity in vivo  Academic Article
• hu-PBL-SCID mice: a model for human immune function, AIDS, and lymphomagenesis  Academic Article
• von Willebrand's disease  Academic Article