subject area of

• -Amino acid substitution of peptide-mediated NF-κB suppression in mdx mice preserves therapeutic benefit in skeletal muscle, but causes kidney toxicity  Academic Article
• 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency  Academic Article
• 5-HT(7) receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern  Academic Article
• 5-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity  Academic Article
• 7-nitroindazole, nitric oxide synthase inhibitor, attenuates physical dependence on butorphanol in rat  Academic Article
• A Bellagio consensus. Children's Vaccine Initiative Ad Hoc Committe on an investment strategy for measles control  Academic Article
• A blueprint for HIV vaccine discovery  Academic Article
• A broadly neutralizing human monoclonal antibody exhibits in vivo efficacy against both human metapneumovirus and respiratory syncytial virus  Academic Article
• A candidate circuit approach to investigating autism  Academic Article
• A cellular mechanism for dendritic spine loss in the pilocarpine model of status epilepticus  Academic Article
• A chimeric mouse model of Gaucher disease  Academic Article
• A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models  Academic Article
• A critical role for the sphingosine analog aal-r in dampening the cytokine response during influenza virus infection  Academic Article
• A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics  Academic Article
• A dystroglycan mutation associated with limb-girdle muscular dystrophy  Academic Article
• A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function  Academic Article
• A genetic analysis of lupus  Academic Article
• A genetically humanized mouse model for hepatitis C virus infection  Academic Article
• A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis  Academic Article
• A human recombinant monoclonal antibody to cocaine: preparation, characterization and behavioral studies  Academic Article
• A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis  Academic Article
• A liver-selective LXR inverse agonist that suppresses hepatic steatosis  Academic Article
• A model for familial exudative vitreoretinopathy caused by LPR5 mutations  Academic Article
• A mouse model for nonsyndromic deafness (dfnb12) links hearing loss to defects in tip links of mechanosensory hair cells  Academic Article
• A mouse model of accelerated liver aging caused by a defect in DNA repair  Academic Article
• A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice  Academic Article
• A multifunctional bispecific antibody protects against Pseudomonas aeruginosa  Academic Article
• A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response  Academic Article
• A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis  Academic Article
• A novel generation of heparan sulfate mimetics for the treatment of prion diseases  Academic Article
• A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease  Academic Article
• A novel synthetic bipartite carrier protein for developing glycotope-based vaccines  Academic Article
• A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects  Academic Article
• A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice  Academic Article
• A plaque-specific antibody clears existing beta-amyloid plaques in Alzheimer's disease mice  Academic Article
• A putative bacterial ABC transporter circumvents the essentiality of signal peptidase  Academic Article
• A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome  Academic Article
• A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition  Academic Article
• A stem cell-based approach to cartilage repair  Academic Article
• A synthetic tlr4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease  Academic Article
• A transgenic mouse model for measles virus infection of the brain  Academic Article
• A transgenic mouse model of the chronic hepatitis B surface antigen carrier state  Academic Article
• A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates  Academic Article
• A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes  Academic Article
• ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC  Academic Article
• Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss  Academic Article
• Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model  Academic Article
• Accelerated aging of intervertebral discs in a mouse model of progeria  Academic Article
• Accelerating next-generation vaccine development for global disease prevention  Academic Article
• Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects  Academic Article
• Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo  Academic Article
• Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1  Academic Article
• Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells  Academic Article
• Activation of HIPK2 promotes ER stress-mediated neurodegeneration in amyotrophic lateral sclerosis  Academic Article
• Activation of brain NOP receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat  Academic Article
• Activation of lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury  Academic Article
• Activation of p38α in T cells regulates the intestinal host defense against attaching and effacing bacterial infections  Academic Article
• Activation of the liver x receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy  Academic Article
• Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: a potential therapeutic target  Academic Article
• Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats  Academic Article
• Activity of hoechst 33258 against Pneumocystis carinii f. sp muris, Candida albicans, and Candida dubliniensis  Academic Article
• Acute immunologic arthritis in rabbits  Academic Article
• Adaptation of energy metabolism in breast cancer brain metastases  Academic Article
• Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-- Jakob disease: implications for human health  Academic Article
• Adaptation, allometry, and hypertension  Academic Article
• Additive effect of stress and drug cues on reinstatement of ethanol seeking: Exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms  Academic Article
• Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway  Academic Article
• Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary-artery model  Academic Article
• Administration of recombinant p-selectin glycoprotein ligand fc fusion protein suppresses inflammation and neointimal formation in zucker diabetic rat model  Academic Article
• Adoptive transfer of human lymphoid cells to severely immunodeficient mice: models for normal human immune function, autoimmunity, lymphomagenesis, and AIDS  Academic Article
• Adult CST-null mice maintain an increased number of oligodendrocytes  Academic Article
• Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees  Academic Article
• Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state  Academic Article
• Alcohol-related genes: Contributions from studies with genetically engineered mice  Academic Article
• Alcoholism: Allostasis and beyond  Academic Article
• Alteration of intracerebral cytokine production in mice infected with herpes-simplex virus type-1 and type-2  Academic Article
• Alteration of methamphetamine-induced stereotypic behaviour in transgenic mice expressing hiv-1 envelope protein gp120  Academic Article
• Alterations in spinal cord metabolism during treatment of neuropathic pain  Academic Article
• Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor  Academic Article
• Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model  Academic Article
• Amelioration of chronic murine colitis by peptide-mediated transduction of the I kappa B kinase inhibitor NEMO binding domain peptide  Academic Article
• Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma  Academic Article
• Aminostyrylbenzofuran directly reduces oligomeric amyloid-β and reverses cognitive deficits in Alzheimer transgenic mice  Academic Article
• Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD  Academic Article
• Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: A possible model for senile systemic amyloidosis  Academic Article
• Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model  Academic Article
• An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model  Academic Article
• An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages  Academic Article
• An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy  Academic Article
• An animal-model to study serum immunoglobulin response to infection by Yersinia-entercocolitica  Academic Article
• An autosomal recessive gene that delays expression of lupus in bxsb mice  Academic Article
• An epigenetic blockade of cognitive functions in the neurodegenerating brain  Academic Article
• An evaluation of the development of experimental membranous nephropathy  Academic Article
• An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints  Academic Article
• Analysis of t-cell function in autoimmune murine strains - defects in production of and responsiveness to interleukin-2  Academic Article
• Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo  Academic Article
• Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase  Academic Article
• Androgen receptor splice variants determine taxane sensitivity in prostate cancer  Academic Article
• Animal model of respiratory syncytial virus: CD8(+) T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy  Academic Article
• Animal models for retrovirus-induced immunodeficiency disease  Academic Article
• Animal models in dengue  Academic Article
• Animal models of craving for ethanol  Academic Article
• Animal models of craving: a roundtable discussion  Academic Article
• Animal models of human amyloidoses: Are transgenic mice worth the time and trouble?  Academic Article
• Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology  Academic Article
• Animal models used to examine the role of the environment in the development of autoimmune disease: Findings from an NIEHS Expert Panel Workshop  Academic Article
• Animal-models of drug craving  Academic Article
• Anti-cd11b antibody prevents immunopathologic changes in viable moth-eaten bone-marrow chimeric mice  Academic Article
• Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones  Academic Article
• Anti-inflammatory activity of superoxide dismutase obtained from Debaryomyces hansenii on type II collagen induced arthritis in rats  Academic Article
• Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke  Academic Article
• Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma  Academic Article
• Antibodies against cd14 protect primates from endotoxin-induced shock  Academic Article
• Antibody SPC-54 provides acute in vivo blockage of the murine protein C system  Academic Article
• Antibody neutralization-resistant primary isolates of human immunodeficiency virus type 1  Academic Article
• Antibody responses to envelope glycoproteins in HIV-1 infection  Academic Article
• Antibody-il-12 fusion proteins are effective in scid mouse models of prostate and colon carcinoma metastases  Academic Article
• Anticonvulsant activity of a nonpeptide galanin receptor agonist  Academic Article
• Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation  Academic Article
• Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress  Academic Article
• Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978  Academic Article
• Antithrombotic activity of protein S infused without activated protein C in a baboon thrombosis model  Academic Article
• Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models  Academic Article
• Application of genomics to toxicology research  Academic Article
• Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor  Academic Article
• Arenavirus genetic diversity and its biological implications  Academic Article
• Arenavirus genome rearrangement for the development of live attenuated vaccines  Academic Article
• Arginine 54 and tyrosine 118 residues of αA-crystallin are crucial for lens formation and transparency  Academic Article
• Association of cartilage-specific deletion of peroxisome proliferator-activated receptor gamma with abnormal endochondral ossification and impaired cartilage growth and development in a murine model  Academic Article
• Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina  Academic Article
• Attenuation of allergic contact dermatitis through the endocannabinoid system  Academic Article
• Attenuation of cue-induced heroin-seeking behavior by cannabinoid CB(1) antagonist infusions into the nucleus accumbens core and prefrontal cortex, but not basolateral amygdala  Academic Article
• Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: Involvement of regulatory T cells  Academic Article
• Autoantibodies to gpi in rheumatoid arthritis: Linkage between an animal model and human disease  Academic Article
• Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients  Academic Article
• Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice  Academic Article
• Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation  Academic Article
• B-cell-tropic interleukins in murine systemic lupus-erythematosus (sle)-1  Academic Article
• BAG1 over-expression in brain protects against stroke  Academic Article
• BCL-2 in prostate cancer: A minireview  Academic Article
• BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice  Academic Article
• Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid.  Academic Article
• Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy  Academic Article
• Basic science of intra-articular fractures and posttraumatic osteoarthritis  Academic Article
• Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells  Academic Article
• Behavioral, biological, and chemical perspectives on targeting crf1 receptor antagonists to treat alcoholism  Academic Article
• Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): Efficacy in an animal model for schizophrenia  Academic Article
• Benzoxazolinone aryl sulfonamides as potent, selective Na(v)1.7 inhibitors with in vivo efficacy in a preclinical pain model  Academic Article
• Beta 1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex  Academic Article
• Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis  Academic Article
• Binding of soluble immune complexes to human lymphoblastoid cells. Ii. Use of raji cells to detect circulating immune complexes in animal and human sera  Academic Article
• Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection  Academic Article
• Biology and pathogenesis of lymphocytic choriomeningitis virus infection  Academic Article
• Biphasic alterations in serotonin-1B (5-HT1B) receptor function during abstinence from extended cocaine self-administration  Academic Article
• Blockade of hypocretin receptor-1 preferentially prevents cocaine seeking: comparison with natural reward seeking  Academic Article
• Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection  Academic Article
• Blockade of the platelet p2y(12) receptor by ar-c69931mx sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis model  Academic Article
• Bornavirus and the brain  Academic Article
• Brain disease model of addiction: why is it so controversial?  Academic Article
• Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury  Academic Article
• Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice  Academic Article
• Bronchoalveolar lavage with KL4-Surfactant in models of meconium aspiration syndrome  Academic Article
• CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120  Academic Article
• CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection.  Academic Article
• Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain  Academic Article
• Can a single subunit yeast nadh dehydrogenase (ndi1) remedy diseases caused by respiratory complex i defects?  Academic Article
• Cancer-specific mutations in PIK3CA are oncogenic in vivo  Academic Article
• Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: An expanded convergent functional genomics approach  Academic Article
• Carboxyfullerene neuroprotection postinjury in Parkinsonian nonhuman primates  Academic Article
• Cellular and behavioral interactions of gabapentin with alcohol dependence  Academic Article
• Cellular events associated with immunogenesis of anti-erythrocyte autoantibody responses of nzb mice  Academic Article
• Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics  Academic Article
• Central nervous system (cns)-resident natural killer cells suppress th17 responses and cns autoimmune pathology  Academic Article
• Central nervous system infection with Borna disease virus causes kynurenine pathway dysregulation and neurotoxic quinolinic acid production  Academic Article
• Centrally administered urocortin 2 decreases gorging on high-fat diet in both diet-induced obesity-prone and -resistant rats  Academic Article
• Changes in locomotor response to beta-endorphin microinfusion during and after opiate abstinence syndrome - a proposal for a model of the onset of mania  Academic Article
• Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse  Academic Article
• Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.  Academic Article
• Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin  Academic Article
• Characterization of a side population of astrocytoma cells in response to temozolomide  Academic Article
• Characterization of cytokine and inos mrna expression in situ during the course of experimental autoimmune myocarditis in rats  Academic Article
• Characterization of mouse mutants with abnormal RPE cells  Academic Article
• Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain  Academic Article
• Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels  Academic Article
• Chemical probes of endocannabinoid metabolism  Academic Article
• Chemoproteomic profiling of host and pathogen enzymes active in cholera  Academic Article
• Chick embryo chorioallantoic membrane models to quantify angiogenesis induced by inflammatory and tumor cells or purified effector molecules  Academic Article
• Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes  Academic Article
• Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test  Academic Article
• Chronic alcohol consumption generates a vulnerable immune environment during early SIV infection in rhesus macaques  Academic Article
• Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking  Academic Article
• Chronic periadolescent alcohol consumption produces persistent cognitive deficits in rhesus macaques  Academic Article
• Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure  Academic Article
• Chronic wasting disease of deer and elk in transgenic mice: Oral transmission and pathobiology  Academic Article
• Chronic wheel running reduces maladaptive patterns of methamphetamine intake: Regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase  Academic Article
• Circadian physiology of metabolism  Academic Article
• Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints  Academic Article
• Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis  Academic Article
• Clinical features of bacterial vaginosis in a murine model of vaginal infection with Gardnerella vaginalis  Academic Article
• Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors  Academic Article
• Combination angiostatic therapies: targeting multiple angiogenic pathways  Academic Article
• Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma  Academic Article
• Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models  Academic Article
• Common genetic mechanisms of blood pressure elevation in two independent rodent models of human essential hypertension  Academic Article
• Comparative analysis of metastasis variants derived from human prostate carcinoma cells: roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion  Academic Article
• Comparative immunological analysis of several murine strains with autoimmune manifestations  Academic Article
• Comparison of mice with accelerated aging caused by distinct mechanisms  Academic Article
• Completion of the entire hepatitis C virus life cycle in genetically humanized mice  Academic Article
• Complex I inhibition in the visual pathway induces disorganization of the node of Ranvier  Academic Article
• Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors  Academic Article
• Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems  Academic Article
• Conditioned withdrawal drives heroin consumption and decreases reward sensitivity  Academic Article
• Connexin mediated cataract prevention in mice  Academic Article
• Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis  Academic Article
• Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility  Academic Article
• Contribution of spinal 5-ht1a and 5-ht7 receptors to locomotor-like movement induced by 8-oh-dpat in spinal cord-transected mice  Academic Article
• Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors  Academic Article
• Convergent functional genomic studies of omega-3 fatty acids in stress reactivity, bipolar disorder and alcoholism  Academic Article
• Convergent functional genomics of anxiety disorders: Translational identification of genes, biomarkers, pathways and mechanisms  Academic Article
• Convergent functional genomics of bipolar disorder: From animal model pharmacogenomics to human genetics and biomarkers  Academic Article
• Convergent functional genomics of psychiatric disorders  Academic Article
• Convergent functional genomics of schizophrenia: From comprehensive understanding to genetic risk prediction  Academic Article
• Convergent functional genomics: a Bayesian candidate gene identification approach for complex disorders  Academic Article
• Convergent integration of animal model and human studies of bipolar disorder (manic-depressive illness)  Academic Article
• Conversion of human fibroblasts into functional cardiomyocytes by small molecules  Academic Article
• Conversion of human fibroblasts to functional endothelial cells by defined factors  Academic Article
• Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model  Academic Article
• Cortical neuronal cytoskeletal changes associated with fiv infection  Academic Article
• Corticotropin-releasing factor (CRF) and alpha 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats  Academic Article
• Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats  Academic Article
• Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection  Academic Article
• Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal CNS  Academic Article
• Critical role of transmethylation in TLR signaling and systemic lupus erythematosus  Academic Article
• Cross-reactive and potent neutralizing antibody responses in human survivors of natural Ebolavirus infection  Academic Article
• Crystallin gamma B-I4F mutant protein binds to alpha-crystallin and affects lens transparency  Academic Article
• Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide  Academic Article
• Cytoplasmic extracts from adipose tissue stromal cells alleviates secondary damage by modulating apoptosis and promotes functional recovery following spinal cord injury  Academic Article
• Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa-induced lung injury in mice  Academic Article
• DISC1 regulates trafficking and processing of APP and Aβ generation  Academic Article
• DNA vaccination against vegf receptor 2 reduces atherosclerosis in ldl receptor-deficient mice  Academic Article
• DNA vaccination can break immunological tolerance to prp in wild-type mice and attenuates prion disease after intracerebral challenge  Academic Article
• Daring to learn from humanized mice  Academic Article
• Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice  Academic Article
• Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders  Academic Article
• Defects in skin γδ T cell function contribute to delayed wound repair in rapamycin-treated mice  Academic Article
• Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances  Academic Article
• Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model  Academic Article
• Deficiency of the cyclin kinase inhibitor P21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoirnmunity  Academic Article
• Defining parameters for successful immunocytotherapy of persistent viral infection  Academic Article
• Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis  Academic Article
• Deletions linked to TP53 loss drive cancer through p53-independent mechanisms  Academic Article
• Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin  Academic Article
• Dense nuclear cataract caused by the γB-crystallin S11R point mutation  Academic Article
• Dentate gyrus volume is reduced before onset of plaque formation in pdapp mice: A magnetic resonance microscopy and stereologic analysis  Academic Article
• Dependence-induced alcohol drinking by alcohol-preferring (p) rats and outbred wistar rats  Academic Article
• Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease  Academic Article
• Design, synthesis and SAR of novel glucokinase activators  Academic Article
• Determination of enzymatic source of alanine aminotransferase activity in serum from dogs with liver injury  Academic Article
• Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection  Academic Article
• Development of a novel vaccine containing binary toxin for the prevention of clostridium difficile disease with enhanced efficacy against NAP1 strains  Academic Article
• Development of approaches to improve cell survival in myoblast transfer therapy  Academic Article
• Development of live-attenuated arenavirus vaccines based on codon deoptimization  Academic Article
• Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming inDrosophila  Academic Article
• Diabetes insipidus in mice with a mutation in aquaporin-2  Academic Article
• Didehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic mice  Academic Article
• Different mechanisms of increased luminal stenosis after arterial injury in mice deficient for urokinase- or tissue-type plasminogen activator  Academic Article
• Differential effects of acute alcohol on prepulse inhibition and event-related potentials in adolescent and adult Wistar rats  Academic Article
• Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy  Academic Article
• Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia.  Academic Article
• Differential role of melanocortin receptor subtypes in cachexia  Academic Article
• Diffuse lung disease in children: summary of a scientific conference  Academic Article
• Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model  Academic Article
• Discovering disease-associated enzymes by proteome reactivity profiling  Academic Article
• Discovery and optimization of a series of pyrimidine-based phosphodiesterase 10A (PDE10A) inhibitors through fragment screening, structure-based design, and parallel synthesis  Academic Article
• Discovery of 5-aryl-1,3-dihydro-2H-imidazo 4,5-b pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis  Academic Article
• Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition  Academic Article
• Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements  Academic Article
• Discovery of novel drugs for promising targets  Academic Article
• Discovery of potent and bioavailable GSK-3β inhibitors  Academic Article
• Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model  Academic Article
• Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na(v)1.7 inhibitors with pain efficacy in mice  Academic Article
• Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis  Academic Article
• Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal  Academic Article
• Distinct antithrombotic consequences of platelet glycoprotein Ibα and VI deficiency in a mouse model of arterial thrombosis  Academic Article
• Distinct patterns of neural activation associated with ethanol seeking: Effects of naltrexone  Academic Article
• Divergent anatomical pattern of d-1 and d-3 binding and dopamine- and cyclic amp-regulated phosphoprotein of 32 kda mrna expression in the roman rat strains: Implications for drug addiction  Academic Article
• Dna immunization and central nervous system viral infection  Academic Article
• Dominant cataracts result from incongruous mixing of wild-type lens connexins  Academic Article
• Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy  Academic Article
• Dopamine d2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats  Academic Article
• Dorsal as well as ventral striatal lesions affect levels of intravenous cocaine and morphine self-administration in rats  Academic Article
• Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats  Academic Article
• Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils  Academic Article
• Dramatic decreases in brain reward function during nicotine withdrawal  Academic Article
• Drug dependence: Stress and dysregulation of brain reward pathways  Academic Article
• Drug target validation: lethal infection blocked by inducible peptide  Academic Article
• Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis  Academic Article
• Dysfunctional gamma delta t cells contribute to impaired keratinocyte homeostasis in mouse models of obesity  Academic Article
• EEG and ERP profiles in the high alcohol preferring (HAP) and low alcohol preferring (LAP) mice: Relationship to ethanol preference  Academic Article
• EPHA2 is associated with age-related cortical cataract in mice and humans  Academic Article
• EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques  Academic Article
• ERK regulation in chronic ethanol exposure and withdrawal  Academic Article
• Early dysfunction of central 5-HT system in a murine model of bovine spongiform encephalopathy  Academic Article
• Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats  Academic Article
• Early spontaneous metastasis in the human epidermoid carcinoma hep3-chick embryo model - contribution of incidental colonization  Academic Article
• Early-onset behavioral and synaptic deficits in a mouse model of alzheimer's disease  Academic Article
• EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin  Academic Article
• Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease  Academic Article
• Editorial overview: Viral pathogenesis  Academic Article
• Effect of amrinone on tumor necrosis factor production in endotoxic shock  Academic Article
• Effect of aripiprazole, a partial dopamine d-2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration  Academic Article
• Effect of chronic hypoxia on detoxication enzymes in rat liver  Academic Article
• Effect of complement depletion on experimental tissue injury  Academic Article
• Effect of experimental cerebral infarction in rat-brain on catecholamines and behavior  Academic Article
• Effect of hyperhomocysteinemia on protein C activation and activity  Academic Article
• Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus  Academic Article
• Effect of sigma(1) receptor antagonism on ethanol and natural reward seeking  Academic Article
• Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen  Academic Article
• Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy  Academic Article
• Effective therapy of the LP-BM5 murine retrovirus-induced lymphoproliferative immunodeficiency disease with diethyldithiocarbamate  Academic Article
• Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL  Academic Article
• Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4  Academic Article
• Effects of a SARS-associated coronavirus vaccine in monkeys  Academic Article
• Effects of cb1 and crf1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: Lack of withdrawal-like responses  Academic Article
• Effects of chronic overexpression of interleukin-1 receptor antagonist in a model of permanent focal cerebral ischemia in mouse  Academic Article
• Effects of crf(1)-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (p) rats  Academic Article
• Effects of cytokine gene therapy on particulate-induced inflammation in the murine air pouch  Academic Article
• Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats  Academic Article
• Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence  Academic Article
• Effects of topical Janus kinase inhibition on ocular surface inflammation and immunity  Academic Article
• Efficacy of synthetic peptide-containing surfactant in the treatment of respiratory distress syndrome in preterm infant rhesus monkeys  Academic Article
• Efficacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice  Academic Article
• Electrophysiological and cerebrovascular effects of the α-secretase-derived form of amyloid precursor protein in young and middle-aged rats  Academic Article
• Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression  Academic Article
• Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation  Academic Article
• Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma  Academic Article
• Embryonic senescence and laminopathies in a progeroid zebrafish model  Academic Article
• Endocannabinoid regulation of amyloid-induced neuroinflammation  Academic Article
• Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies  Academic Article
• Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection  Academic Article
• Endothelial protein C receptor function in murine and human breast cancer development  Academic Article
• Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease  Academic Article
• Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice  Academic Article
• Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P(1) antagonist in vivo  Academic Article
• Enhancement of experimental allergic encephalomyelitis (eae) by DNA immunization with myelin proteolipid protein (plp) plasmid DNA  Academic Article
• Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells  Academic Article
• Envelope exchange for the generation of live-attenuated arenavirus vaccines  Academic Article
• Epilepsy, cns viral injury and dynorphin  Academic Article
• Epstein-Barr virus-induced human B-cell lymphomas in SCID mice reconstituted with human peripheral blood leukocytes  Academic Article
• Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders  Academic Article
• Escalating morphine exposures followed by withdrawal in feline immunodeficiency virus-infected cats: a model for HIV infection in chronic opiate abusers  Academic Article
• Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels  Academic Article
• Escalation of drug self-administration as a hallmark of persistent addiction liability  Academic Article
• Escalation patterns of varying periods of heroin access  Academic Article
• Etiopathogenesis of murine sle  Academic Article
• Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality  Academic Article
• Evaluation of fatty acid amides in the carrageenan-induced paw edema model  Academic Article
• Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants  Academic Article
• Evaluation of metastatic and angiogenic potentials of human colon carcinoma cells in chick embryo model systems  Academic Article
• Evaluation of the echinocandin antifungal mk-0991 (l-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis  Academic Article
• Event-related oscillations as risk markers in genetic mouse models of high alcohol preference  Academic Article
• Evidence for genetic association of RORB with bipolar disorder  Academic Article
• Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice  Academic Article
• Evidence that the hypermutated m protein of a subacute sclerosing panencephalitis measles virus actively contributes to the chronic progressive cns disease  Academic Article
• Evidence that vasopressin V(1b) receptors mediate the transition to excessive drinking in ethanol-dependent rats  Academic Article
• Ex vivo gene delivery of il-1ra and soluble tnf receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis  Academic Article
• Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation  Academic Article
• Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA  Academic Article
• Exosomes derived from genetically modified dc expressing fasl are anti-inflammatory and immunosuppressive  Academic Article
• Experimental glomerulonephritis induced by in situ formation of immune-complexes in glomerular capillary wall  Academic Article
• Experimental psychiatric illness and drug abuse models: from human to animal, an overview  Academic Article
• Experimental renal disease induced by DNA-anti-DNA immune complexes  Academic Article
• Experimental skin lesions in mice resembling systemic lupus erythematosus  Academic Article
• Experimental-models of coronary-artery restenosis  Academic Article
• Exposure of neonatal rats to alcohol by vapor inhalation demonstrates specificity of microcephaly and purkinje-cell loss but not astrogliosis  Academic Article
• Expression of type 1 plasminogen activator inhibitor in renal tissue in murine lupus nephritis  Academic Article
• Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments  Academic Article
• Extensive cell migration, axon regeneration, and improved function with polysialic acid-modified Schwann cells after spinal cord injury  Academic Article
• Extracellular-matrix accumulation in immune-mediated tubulointerstitial injury  Academic Article
• FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation  Academic Article
• FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination  Academic Article
• FXa takes center stage in vascular inflammation  Academic Article
• Facilitation of spike-wave discharge activity by lipopolysaccharides in Wistar Albino Glaxo/Rijswijk rats  Academic Article
• Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation  Academic Article
• Failure of heparin to affect 2 types of experimental glomerulonephritis in rabbits  Academic Article
• Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice  Academic Article
• Fatty acid amide hydrolase deficiency limits early pregnancy events  Academic Article
• Feeding microstructure in diet-induced obesity susceptible versus resistant rats: Central effects of urocortin 2  Academic Article
• Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV  Academic Article
• Feline immunodeficiency virus as a model for study of lentivirus infection of the central nervous system  Academic Article
• First-in-class inhibitors of sulfur metabolism with bactericidal activity against non-replicating M. tuberculosis  Academic Article
• Fluorescent histochemical study of changes in noradrenergic neurons following experimental cerebral infarction in rat  Academic Article
• Forkhead box protein p1 is a transcriptional repressor of immune signaling in the cns: Implications for transcriptional dysregulation in huntington disease  Academic Article
• Formation of gelsolin amyloid fibrils in the rough endoplasmic reticulum of skeletal muscle in the gelsolin mouse model of inclusion body myositis: comparative analysis to human sporadic inclusion body myositis  Academic Article
• Frequent exposure of mice to crude Brucella abortus proteins down-regulates immune response  Academic Article
• Functional interaction between opioid and cannabinoid receptors in drug self-administration  Academic Article
• Functional recovery after embolic stroke in rodents by activated protein C  Academic Article
• Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination  Academic Article
• GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease  Academic Article
• GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes  Academic Article
• GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models  Academic Article
• Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5  Academic Article
• Gamma delta t cells are reduced and rendered unresponsive by hyperglycemia and chronic tnf alpha in mouse models of obesity and metabolic disease  Academic Article
• Gamma delta t cells in host defense and epithelial cell biology  Academic Article
• Gender differences in autoimmunity associated with exposure to environmental factors  Academic Article
• Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats  Academic Article
• Gene therapy for autoimmune disorders  Academic Article
• Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4  Academic Article
• Gene therapy for osteoporosis: Evaluation in a murine ovariectomy model  Academic Article
• Gene therapy for rheumatoid arthritis  Academic Article
• Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCIS mouse model  Academic Article
• Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes  Academic Article
• Generation and analysis of an rna vaccine that protects against coxsackievirus b3 challenge  Academic Article
• Generation and phenotypic analysis of protein S-deficient mice  Academic Article
• Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome  Academic Article
• Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest  Academic Article
• Genetic deficiency in pparg does not alter development of experimental prostate cancer  Academic Article
• Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis  Academic Article
• Genetic dissection of innate immunity to infection: The mouse cytomegalovirus model  Academic Article
• Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat  Academic Article
• Genetic risk prediction and neurobiological understanding of alcoholism  Academic Article
• Genetical genomic determinants of alcohol consumption in rats and humans  Academic Article
• Genetics of SLE in mice  Academic Article
• Genetics of systemic autoimmunity and glomerulonephritis in mouse models of lupus  Academic Article
• Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii  Academic Article
• Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates alzheimer's disease-related neuropathies: Involvement of non-amyloidogenic processing  Academic Article
• Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex  Academic Article
• Glomerular antigens in glomerulonephritis  Academic Article
• Glomerular effects of pregnancy in a model of glomerulonephritis in the rat  Academic Article
• Glomerular extracellular matrix accumulation in experimental anti-GEM Ab glomerulonephritis  Academic Article
• Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease  Academic Article
• Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat  Academic Article
• HBV pathogenesis in animal models: recent advances on the role of platelets  Academic Article
• HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation  Academic Article
• HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model  Academic Article
• HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria  Academic Article
• Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone  Academic Article
• Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells  Academic Article
• Hematopoietic stem cell gene therapy for the multisystemic lysosomal storage disorder cystinosis  Academic Article
• Hemostatic gene expression and vascular disease in obesity: insights from studies of genetically obese mice  Academic Article
• Hepatitis B virus structure and biology  Academic Article
• Hepatitis B virus transgenic mice: Models of viral immunobiology and pathogenesis  Academic Article
• Heregulin-ErbB3-driven tumor growth persists in PI3 kinase mutant cancer cells  Academic Article
• Heterogeneity of Alcohol Use Disorder: Understanding Mechanisms to Advance Personalized Treatment  Academic Article
• Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice  Academic Article
• High-resolution mutational profiling suggests the genetic validity of glioblastoma patient-derived pre-clinical models  Academic Article
• High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations  Academic Article
• Highly potent RANTES analogues either prevent CCR5-using human immunodeficiency virus type 1 infection in vivo or rapidly select for CXCR4-using variants  Academic Article
• Hippocampal and septal injections of nicotine and 8-oh-dpat distinguish among different animal tests of anxiety  Academic Article
• Hippocampal neurogenesis protects against cocaine-primed relapse  Academic Article
• Histone H2A-mediated transient cytokine gene delivery induces efficient antitumor responses in murine neuroblastoma  Academic Article
• Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of huntington's disease  Academic Article
• Histone deacetylase inhibitor suppression of auto antibody-mediated arthritis in mice via regulation of p16(INK4a) and p21(WAF1/Cip1) expression  Academic Article
• Histone posttranslational modifications in schizophrenia  Academic Article
• HlF-2 alpha deletion promotes kras-driven lung tumor development  Academic Article
• Human CD22 inhibits murine B cell receptor activation in a human CD22 transgenic mouse model  Academic Article
• Human immunodeficiency virus infection of human-PBL-SCID mice  Academic Article
• Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment  Academic Article
• Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes  Academic Article
• Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis  Academic Article
• Human periprosthetic tissues implanted in severe combined immunodeficient mice respond to gene transfer of a cytokine inhibitor  Academic Article
• Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis  Academic Article
• Human xenograft models for virus infection  Academic Article
• Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1  Academic Article
• Hydrodynamic injection of viral DNA: A mouse model of acute hepatitis B virus infection  Academic Article
• Hyperoncotic albumin infusion in experimental glomerulonephritis in rats - micropuncture study  Academic Article
• Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger  Academic Article
• Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats  Academic Article
• ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus  Academic Article
• ICOS-dependent extrafollicular helper T cells elicit igg production via IL-21 in systemic autoimmunity  Academic Article
• IKK beta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis  Academic Article
• IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects  Academic Article
• IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms  Academic Article
• IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice  Academic Article
• IP3 3-kinase B prevents bone marrow failure  Academic Article
• Id2 is dispensable for myc-induced lymphomagenesis  Academic Article
• Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach  Academic Article
• Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9  Academic Article
• Identifying the long-term role of inducible nitric oxide synthase after contusive spinal cord injury using a transgenic mouse model  Academic Article
• Ifit1 protects against lipopolysaccharide and D-galactosamine-induced fatal hepatitis by inhibiting activation of the JNK Pathway  Academic Article
• IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model  Academic Article
• Il-5 links adaptive and natural immunity specific for epitopes of oxidized ldl and protects from atherosclerosis  Academic Article
• Imaging androgen receptor signaling with a radiotracer targeting free prostate-specific antigen  Academic Article
• Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis  Academic Article
• Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models  Academic Article
• Immune aspects of renal diseases  Academic Article
• Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus  Academic Article
• Immunocytokines: A promising approach to cancer immunotherapy  Academic Article
• Immunodeficient mice xenografted with human lymphoid cells: new models for in vivo studies of human immunobiology and infectious diseases  Academic Article
• Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris  Academic Article
• Immunopathogenicity and oncogenicity of murine leukemia viruses. I. Induction of immunologic disease and lymphoma in (balb-c times nzb)f1 mice by scripps leukemia virus  Academic Article
• Immunopathology and pathogenesis of cutaneous involvement in systemic lupus erythematosus  Academic Article
• Immunopathology during coxsackievirus infection  Academic Article
• Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection  Academic Article
• Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases  Academic Article
• Improving the pharmacokinetic and CYP inhibition profiles of azaxanthene-based glucocorticoid receptor modulators-identification of (S)-5-(2-(9-fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5H-chromeno[2,3-b]pyridin-5-yl)-2-methylpropanamido)-N-(tetrahydro-2H-pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide (BMS-341)  Academic Article
• In a transgenic model of spontaneous autoimmune diabetes, expression of a protective class II MHC molecule results in thymic deletion of diabetogenic CD8+ T cells  Academic Article
• In the hypoxic central nervous system, endothelial cell proliferation is followed by astrocyte activation, proliferation, and increased expression of the alpha 6 beta 4 integrin and dystroglycan  Academic Article
• In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi  Academic Article
• In vivo ablation of type I interferon receptor from cardiomyocytes delays coxsackieviral clearance and accelerates myocardial disease  Academic Article
• In vivo and in vitro production of anti-histone antibodies in NZB/NZW mice  Academic Article
• In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons  Academic Article
• In vivo complementation of complex i by the yeast ndi1 enzyme - possible application for treatment of parkinson disease  Academic Article
• In vivo potent BM635 analogue with improved drug-like properties  Academic Article
• In vivo treatment with a mhc class i-restricted blocking peptide can prevent virus-induced autoimmune diabetes  Academic Article
• Increase of anti-metastatic efficacy by selectivity-but not affinity-optimization of synthetic serine protease inhibitors  Academic Article
• Increased c-fos expression in the central nucleus of the amygdala and enhancement of cued fear memory in dyt1 delta gag knock-in mice  Academic Article
• Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction  Academic Article
• Increased expression of thrombospondin-1 in vessel wall of diabetic zucker rat  Academic Article
• Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase  Academic Article
• Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation  Academic Article
• Induction of a protective immune response against viral nervous necrosis in the european sea bass dicentrarchus labrax by using betanodavirus virus-like particles  Academic Article
• Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded microRNA-15a  Academic Article
• Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3  Academic Article
• Induction, characterization, and cell transfer of autoimmune tubulointerstitial nephritis  Academic Article
• Infection of cats with molecularly cloned and biological isolates of the feline immunodeficiency virus  Academic Article
• Infection with MERS-CoV causes lethal pneumonia in the common marmoset  Academic Article
• Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity  Academic Article
• Inflammatory cytokines: Putative regulators of neuronal and neuro-endocrine function  Academic Article
• Influence of cortisone on seizure activity in Papio-papio model of epilepsy  Academic Article
• Influence of local delivery of the protein tyrosine kinase receptor inhibitor tyrphostin-47 on smooth-muscle cell proliferation in a rat carotid balloon-injury model  Academic Article
• Influence of thymic genotype on the systemic lupus erythematosus-like disease and t-cell proliferation of mrl-mp-lpr-lpr mice  Academic Article
• Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity  Academic Article
• Influenza virus-like particles engineered by protein transfer with tumor-associated antigens induces protective antitumor immunity  Academic Article
• Infrared fluorescence for vascular barrier breach in vivo - a novel method for quantitation of albumin efflux  Academic Article
• Inhibiting oxidative phosphorylation in vivo restrains Th17 effector responses and ameliorates murine colitis  Academic Article
• Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay  Academic Article
• Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4  Academic Article
• Inhibition of inflammation with celastrol fails to improve muscle function in dysferlin-deficient A/J mice  Academic Article
• Inhibition of mutation and combating the evolution of antibiotic resistance  Academic Article
• Inhibition of the IKK/NF-kappa B pathway by AAV gene transfer improves muscle regeneration in older mdx mice  Academic Article
• Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects  Academic Article
• Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease  Academic Article
• Inhibitory effects of berberine against morphine-induced locomotor sensitization and analgesic tolerance in mice  Academic Article
• Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance  Academic Article
• Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes  Academic Article
• Interferon-γ production by peripheral lymphocytes predicts survival of tumor-bearing mice receiving dual PD-1/CTLA-4 blockade  Academic Article
• Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma  Academic Article
• Interleukin-1β contributes to the generation of experimental febrile seizures  Academic Article
• Interleukin-6 promotes systemic lupus erythematosus progression with Treg suppression approach in a murine systemic lupus erythematosus model  Academic Article
• Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons  Academic Article
• Interruption of vascular thrombosis by bolus anti-platelet glycoprotein IIb/IIIa monoclonal antibodies in baboons  Academic Article
• Intersecting pathways to neurodegeneration in parkinson's disease: Effects of the pesticide rotenone on dj-1, alpha-synuclein, and the ubiquitin-proteasome system  Academic Article
• Interstitial nephritis in rats immunized with heterologous tubular basement-membrane  Academic Article
• Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis  Academic Article
• Intracerebroventricular injection of amyloid-β peptides in normal mice to acutely induce alzheimer-like cognitive deficits  Academic Article
• Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke  Academic Article
• Intrathecal recombinant human 4-sulfatase reduces accumulation of glycosaminoglycans in dura of mucopolysaccharidosis VI cats  Academic Article
• Intratumoral cancer cell intravasation can occur independent of invasion into the adjacent stroma  Academic Article
• Investigating the role of DNA damage in tobacco smoking-induced spine degeneration  Academic Article
• Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus  Academic Article
• Is tissue plasminogen activator a threat to neurons?  Academic Article
• Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model  Academic Article
• Issls prize winner: Inhibition of nf-kappa b activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging  Academic Article
• Jinx, an mcmv susceptibility phenotype caused by disruption of unc13d: A mouse model of type 3 familial hemophagocytic lymphohistiocytosis  Academic Article
• Kappa opioid control of seizures produced by a virus in an animal model  Academic Article
• Kidney preservation by bone marrow cell transplantation in hereditary nephropathy  Academic Article
• Kidney repair and stem cells: A complex and controversial process  Academic Article
• Kinase mutations in human disease: Interpreting genotype-phenotype relationships  Academic Article
• Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis  Academic Article
• LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage  Academic Article
• LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation  Academic Article
• LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth  Academic Article
• Lack of prion infectivity in fixed heart tissue from patients with Creutzfeldt-Jakob disease or amyloid heart disease  Academic Article
• Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease  Academic Article
• Lacrimal gland inflammation deregulates extracellular matrix remodeling and alters molecular signature of epithelial stem/progenitor cells  Academic Article
• Lactational and postnatal exposure to polychlorinated biphenyls induces sex-specific anxiolytic behavior and cognitive deficit in mice offspring  Academic Article
• Late administration of monoclonal-antibody to leukocyte function-antigen 1 abrogates incipient murine cerebral malaria  Academic Article
• Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice  Academic Article
• Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (sigma r1)  Academic Article
• Lead optimization of antimalarial propafenone analogues  Academic Article
• Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin alpha v beta 5: implications for angiogenesis in human obesity  Academic Article
• Leptin promotes vascular remodeling and neointimal growth in mice  Academic Article
• Lessons from the cat: Feline immunodeficiency virus as a tool to develop intervention strategies against human immunodeficiency virus type 1  Academic Article
• Lethal alpha-thalassemia created by gene targeting in mice and its genetic rescue  Academic Article
• Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM)  Academic Article
• Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver  Academic Article
• Lipopolysaccharide induction of tissue factor expression in rabbits  Academic Article
• Lipoproteins accumulate in immune deposits and are modified by lipid peroxidation in passive heymann nephritis  Academic Article
• Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile x syndrome  Academic Article
• Localization of cholesterol, amyloid and glia in alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (tof-sims) and immunofluorescence imaging  Academic Article
• Long-term evaluation of Leber's hereditary optic neuropathy-like symptoms in rotenone administered rats  Academic Article
• Longitudinal analysis of behavioral, neurophysiological, viral and immunological effects of SIV infection in rhesus monkeys  Academic Article
• Lop12, a mutation in mouse Crygd causing lens opacity similar to human Coppock cataract  Academic Article
• Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation  Academic Article
• Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies  Academic Article
• Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats  Academic Article
• Low-affinity cytotoxic t-lymphocytes require ifn-gamma to clear an acute viral infection  Academic Article
• Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma  Academic Article
• Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity  Academic Article
• Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice  Academic Article
• Lysophosphatidic acid signaling may initiate fetal hydrocephalus  Academic Article
• Lysophosphatidic acid stimulates the intestinal brush border NA(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF  Academic Article
• MOR209/ES414, a novel bispecific antibody targeting PSMA for the treatment of metastatic castration-resistant prostate cancer  Academic Article
• Machine learning models and pathway genome data base for trypanosoma cruzi drug discovery  Academic Article
• Macro view of microrna function in osteoarthritis  Academic Article
• Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy  Academic Article
• Manipulation of Panx1 activity increases the engraftment of transplanted lacrimal gland epithelial progenitor cells  Academic Article
• Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: An immediate source for thousands of new mouse models  Academic Article
• Measles virus infection in a transgenic model: Virus-induced immunosuppression and central nervous system disease  Academic Article
• Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats  Academic Article
• Mechanism of toxicity in rotenone models of parkinson's disease  Academic Article
• Mechanisms of acute kidney injury induced by experimental Lonomia obliqua envenomation  Academic Article
• Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis  Academic Article
• Mechanisms underlying hypoxia tolerance in drosophila melanogaster: Hairy as a metabolic switch  Academic Article
• Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs  Academic Article
• Melanocortin pathway: Animal models of obesity and disease  Academic Article
• Melanopsin contributions to irradiance coding in the thalamo-cortical visual system  Academic Article
• Merlin in organ size control and tumorigenesis: Hippo versus EGFR?  Academic Article
• Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia  Academic Article
• Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease  Academic Article
• MiR-980 is a memory suppressor microRNA that regulates the autism-susceptibility gene A2bp1  Academic Article
• Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia  Academic Article
• MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer  Academic Article
• Microorganisms and autoimmunity: Making the barren field fertile?  Academic Article
• Microrna-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function  Academic Article
• Mimicry of high-density lipoprotein: functional peptide-lipid nanoparticles based on multivalent peptide constructs  Academic Article
• Modeling AIDS in a mouse  Academic Article
• Modeling a task that is sensitive to dementia of the Alzheimer's type: individual differences in acquisition of a visuo-spatial paired-associate learning task in rhesus monkeys  Academic Article
• Modeling human methamphetamine exposure in nonhuman primates: chronic dosing in the rhesus macaque leads to behavioral and physiological abnormalities  Academic Article
• Modeling relapse in animals  Academic Article
• Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control  Academic Article
• Modulation of disease-activity in murine systemic lupus-erythematosus by cytokine gene delivery  Academic Article
• Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis  Academic Article
• Molecular analysis of the murine lupus-associated anti-self response - involvement of a large number of heavy and light chain variable region genes  Academic Article
• Molecular and cell biology of the prototypic arenavirus LCMV: Implications for understanding and combating hemorrhagic fever arenaviruses  Academic Article
• Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry  Academic Article
• Molecular and chemical genetic approaches to developmental origins of aging and disease in zebrafish  Academic Article
• Molecular cloning and functional characterization of zebrafish ATM  Academic Article
• Molecular genetics of murine lupus models  Academic Article
• Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition  Academic Article
• Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties  Academic Article
• Molecular mechanisms of fiv infection  Academic Article
• Molecular mimicry, microbial infection, and autoimmune disease: evolution of the concept  Academic Article
• Molecular pathway to protection from age-dependent photoreceptor degeneration in Mef2 deficiency  Academic Article
• Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice  Academic Article
• Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling  Academic Article
• Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of Down syndrome  Academic Article
• Monoclonal anti-histone autoantibodies derived from murine models of lupus  Academic Article
• Monoclonal autoantibodies to nuclear antigens from murine graft-versus-host disease  Academic Article
• Monoclonal igm rheumatoid factors derived from arthritic mrl mp-lpr lpr mice  Academic Article
• Monocyte chemoattractant protein-1 expression correlates with monocyte infiltration in the post-ischemic kidney  Academic Article
• Motoneuron development influences dorsal root ganglia survival and Schwann cell development in a vertebrate model of spinal muscular atrophy  Academic Article
• Mouse genetics at work: a new model of chronic hepadnavirus infection - Comments  Academic Article
• Mouse liver repopulation with hepatocytes generated from human fibroblasts  Academic Article
• Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes  Academic Article
• Mouse model of subretinal neovascularization with choroidal anastomosis  Academic Article
• Mouse models for dengue vaccines and antivirals  Academic Article
• Mouse models for generating p53 gene mutation spectra  Academic Article
• Mouse models for melanoma: A personal perspective  Academic Article
• Mouse models of fanconi anemia  Academic Article
• Mouse models of hepatitis B virus pathogenesis  Academic Article
• Mouse models of human neurodegenerative disorders - requirements for medication development  Academic Article
• Multifunctional in vivo imaging of pancreatic islets during diabetes development  Academic Article
• Multiple oncogenes and tumor suppressor genes are structurally and functionally intact during hepatocarcinogenesis in hepatitis B virus transgenic mice  Academic Article
• Murine models of systemic lupus-erythematosus  Academic Article
• Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model  Academic Article
• Mutation in fucose synthesis gene of Klebsiella pneumoniae affects capsule composition and virulence in mice  Academic Article
• Mutation of the gastric hydrogen-potassium atpase alpha subunit causes iron-deficiency anemia in mice  Academic Article
• Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma  Academic Article
• Myd88 deficiency attenuates angiotensin ii-induced abdominal aortic aneurysm formation independent of signaling through toll-like receptors 2 and 4  Academic Article
• Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and t cell responses are unaffected by immunoproteasome deficiency  Academic Article
• Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy  Academic Article
• N,n-diethyl-4- (3-hydroxyphenyl)(piperidin-4-yl)amino benzamide derivatives: The development of diaryl amino piperidines as potent delta opioid receptor agonists with in vivo anti-nociceptive activity in rodent models  Academic Article
• NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity  Academic Article
• Nanostructure-initiator mass spectrometry (NIMS) imaging of brain cholesterol metabolites in Smith-Lemli-Opitz syndrome  Academic Article
• Natural history of Francisella tularensis in aerosol-challenged BALB/c Mice  Academic Article
• Nelumbinis semen reverses a decrease in hippocampal 5-ht release induced by chronic mild stress in rats  Academic Article
• Neointimal formation after endovascular arterial injury is markedly attenuated in db/db mice  Academic Article
• Neointimal hyperplasia after arterial injury is increased in a rat model of non-insulin-dependent diabetes mellitus  Academic Article
• Nephritogenic antibody mechanisms involving antigens within the glomerulus  Academic Article
• Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization  Academic Article
• Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models  Academic Article
• Neural stem cells improve cognition via bdnf in a transgenic model of alzheimer disease  Academic Article
• Neurobiological evidence for hedonic allostasis associated with escalating cocaine use  Academic Article
• Neurobiological mechanisms of addiction: Focus on corticotropin-releasing factor  Academic Article
• Neurogenesis is required for behavioral recovery after injury in the visual system of Xenopus laevis  Academic Article
• Neuronal production of transthyretin in human and murine Alzheimer's disease: Is it protective?  Academic Article
• Neuropeptide changes in a primate model (cebus-apella) for tardive-dyskinesia  Academic Article
• Neuropeptide expression in rats exposed to chronic mild stresses  Academic Article
• Neuropharmacological sequelae of persistent cns viral infections: Lessons from borna disease virus  Academic Article
• Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat  Academic Article
• Neuroprotective effect of long-term ndi1 gene expression in a chronic mouse model of parkinson disorder  Academic Article
• Neuroprotective effects of eucommia ulmoides oliv. Bark on amyloid beta(25-35)-induced learning and memory impairments in mice  Academic Article
• Neuroscience of addiction  Academic Article
• Neurotoxic effects of feline immunodeficiency virus, FIV-PPR  Academic Article
• Neutralization takes precedence over IgG or IgA isotype-related functions in mucosal HIV-1 antibody-mediated protection  Academic Article
• Neutralizing Polyclonal IgG Present during Acute Infection Prevents Rapid Disease Onset in Simian-Human Immunodeficiency Virus SHIVSF162P3-Infected Infant Rhesus Macaques  Academic Article
• Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo  Academic Article
• Neutrophil activation by the tissue factor/factor viia/par2 axis mediates fetal death in a mouse model of anti phospholipid syndrome  Academic Article
• New dimensions in human laboratory models of addiction  Academic Article
• New model systems for hepatitis B virus research  Academic Article
• New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales  Academic Article
• New therapeutic targets revealed through investigations of innate immunity  Academic Article
• Nicotine vapor inhalation escalates nicotine self-administration  Academic Article
• Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation  Academic Article
• Non-invasive multimodality imaging directly shows TRPM4 inhibition ameliorates stroke reperfusion injury  Academic Article
• Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome  Academic Article
• Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein a-i  Academic Article
• Nonhuman primate models and the failure of the merck hiv-1 vaccine in humans  Academic Article
• Notch signaling in pancreatic cancer: oncogene or tumor suppressor?  Academic Article
• Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects  Academic Article
• Novel mouse model of autosomal semidominant adult Hypophosphatasia has a splice site mutation in the tissue nonspecific alkaline phosphatase gene Akp2  Academic Article
• Novel origin of lpr and gld cells and possible implications in autoimmunity  Academic Article
• Novel second generation analogs of eribulin. Part III: Blood-brain barrier permeability and in vivo activity in a brain tumor model  Academic Article
• Novel strategy for inhibiting viral entry by use of a cellular receptor-plant virus chimera  Academic Article
• Novel tricyclic antagonists of the prostaglandin D-2 receptor DP2 with efficacy in a murine model of allergic rhinitis  Academic Article
• Nuclear covalently closed circular viral genomic DNA in the liver of hepatocyte nuclear factor 1 alpha-null hepatitis B virus transgenic mice  Academic Article
• Nucleotide excision repair deficient mouse models and neurological disease  Academic Article
• Obligatory role for complex i inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)  Academic Article
• On the SCIDs?  Academic Article
• On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models  Academic Article
• Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function  Academic Article
• Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism  Academic Article
• One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the blt model for evaluation of new microbicide candidates  Academic Article
• Operant alcohol self-administration in dependent rats: focus on the vapor model  Academic Article
• Opiate withdrawal-induced place aversion lasts for up to 16 weeks  Academic Article
• Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy  Academic Article
• Optic nerve axon number in mouse is regulated by PAX2  Academic Article
• Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models  Academic Article
• Oral exposure to Listeria monocytogenes in aged IL-17RKO mice: A possible murine model to study listeriosis in susceptible populations  Academic Article
• Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor  Academic Article
• Osteoarthritis gene therapy  Academic Article
• Ovariectomy and genes encoding core circadian regulatory proteins in murine bone  Academic Article
• Overexpression of human apoai transgene provides long-term atheroprotection in ldl receptor-deficient mice  Academic Article
• PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis  Academic Article
• PAI-1, fibrosis, and the elusive provisional fibrin matrix  Academic Article
• Pan-ebolavirus and pan-filovirus mouse monoclonal antibodies: protection against Ebola and Sudan viruses  Academic Article
• Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1  Academic Article
• Participation of macrophages and monocytes in experimental immune-complex glomerulonephritis  Academic Article
• Participation of tumor necrosis factor in the mediation of gram-negative bacterial lipopolysaccharide-induced injury in rabbits  Academic Article
• Passive immunization with a human monoclonal antibody protects hu-pbl-scid mice against challenge by primary isolates of hiv-1  Academic Article
• Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus  Academic Article
• Pathogenesis of cytomegalovirus-infection .1. Activation of virus from bone marrow-derived lymphocytes by in vitro allogenic reaction  Academic Article
• Pathogenesis of slow disease of central nervous-system associated with wm-1504-e virus  Academic Article
• Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses  Academic Article
• Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris  Academic Article
• Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice  Academic Article
• Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus  Academic Article
• Performing subretinal injections in rodents to deliver retinal pigment epithelium cells in suspension  Academic Article
• Peripheral reduction of beta-amyloid is sufficient to reduce brain beta-amyloid: Implications for alzheimer's disease  Academic Article
• Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence  Academic Article
• Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase  Academic Article
• Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer  Academic Article
• Pharmacokinetics and efficacy of the spleen tyrosine kinase inhibitor r406 after ocular delivery for retinoblastoma  Academic Article
• Pharmacological activation of the neurotensin receptor 1 abrogates the methamphetamine-induced striatal apoptosis in the mouse brain  Academic Article
• Pharmacological approaches for the prevention of restenosis after percutaneous coronary intervention  Academic Article
• Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation  Academic Article
• Pharmacological characterization of the late phase reduction in lung functions and correlations with microvascular leakage and lung edema in allergen-challenged Brown Norway rats  Academic Article
• Pharmacological evaluation of selective α2c-adrenergic agonists in experimental animal models of nasal congestion  Academic Article
• Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials  Academic Article
• Pharmacological selectivity within class I histone deacetylases predicts effects on synaptic function and memory rescue  Academic Article
• Pharmacological treatment following experimental cerebral infarction - implications for understanding psychological symptoms of human stroke  Academic Article
• Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism  Academic Article
• Phenotypic characterization of a genetically diverse panel of mice for behavioral despair and anxiety  Academic Article
• Phosphoinositide 3-kinase regulates glycolysis through mobilization of aldolase from the actin cytoskeleton  Academic Article
• Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class i histone deacetylases  Academic Article
• Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses  Academic Article
• Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease  Academic Article
• Platelet glycoprotein Ib alpha supports experimental lung metastasis  Academic Article
• Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia  Academic Article
• Platelets mediate cytotoxic T lymphocyte-induced liver damage  Academic Article
• Plazomicin is effective in a non-human primate pneumonic plague model  Academic Article
• Positive end-expiratory pressure during KL4 surfactant instillation enhances intrapulmonary distribution in a simian model of respiratory distress syndrome  Academic Article
• Post-ictal locomotor-activity in 3 different rat models of epilepsy  Academic Article
• Postcocaine anhedonia: an animal model of cocaine withdrawal  Academic Article
• Potential of small molecule-mediated reprogramming of rod photoreceptors to treat retinitis pigmentosa  Academic Article
• Potential of the scid mouse as a host for human tumors  Academic Article
• PrP(TSE) distribution in a primate model of variant, sporadic, and iatrogenic Creutzfeldt-Jakob disease  Academic Article
• Pre- and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody  Academic Article
• Preclinical metabolic changes in mouse prion diseases detected by 1H-nuclear magnetic resonance spectroscopy  Academic Article
• Preclinical studies for pharmacokinetics and biodistribution of AD-stTRAIL, an adenovirus delivering secretable trimeric trail for gene therapy  Academic Article
• Preclinical trials using an immunoconjugate of t101 and methotrexate in an athymic mouse human t-cell tumor-model  Academic Article
• Preclinical validation of a novel cocaine exposure therapy for relapse prevention  Academic Article
• Preliminary PET study of F-18-FC119S in normal and Alzheimer's disease models  Academic Article
• Premature aging-related peripheral neuropathy in a mouse model of progeria  Academic Article
• Prenatal and postnatal exposure to bisphenol a induces anxiolytic behaviors and cognitive deficits in mice  Academic Article
• Presence of anti-Sm reactivity in autoimmune mouse strains  Academic Article
• Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model  Academic Article
• Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation  Academic Article
• Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury  Academic Article
• Prion-induced amyloid heart disease with high blood infectivity in transgenic mice  Academic Article
• Prioritizing the development of mouse models for childhood brain disorders  Academic Article
• Procoagulant activity on injured arteries and associated thrombi is mediated primarily by the complex of tissue factor and factor viia  Academic Article
• Progress in corticotropin-releasing factor-1 antagonist development  Academic Article
• Prolonged hypercholesterolemia-induced tissue factor expression in rabbit vein grafts: A potential mechanism for graft failure  Academic Article
• Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat  Academic Article
• Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model  Academic Article
• Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies  Academic Article
• Proteases and oxidants in experimental pulmonary inflammatory injury  Academic Article
• Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness  Academic Article
• Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in ldl receptor-deficient mice  Academic Article
• Protection against colitis by CD100-dependent modulation of intraepithelial gamma delta T lymphocyte function  Academic Article
• Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid  Academic Article
• Protection from the 2009 h1n1 pandemic influenza by an antibody from combinatorial survivor-based libraries  Academic Article
• Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy  Academic Article
• Protection of nude mice by passive immunization with a type-common human recombinant monoclonal antibody against hsv  Academic Article
• Protection of the intestinal mucosa by intraepithelial gamma delta T cells  Academic Article
• Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1  Academic Article
• Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration  Academic Article
• Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis  Academic Article
• Protein transduction: Identification, characterization and optimization  Academic Article
• Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis  Academic Article
• Pyelonephritic escherichia coli expressing p fimbriae decrease immune response of the mouse kidney  Academic Article
• Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists  Academic Article
• Quantitative evaluation of local drug delivery using the infusasleeve catheter  Academic Article
• Quantitative in vivo and ex vivo confocal microscopy analysis of corneal cystine crystals in the Ctns(-/-) knockout mouse  Academic Article
• Quantitative polymerase chain-reaction analysis reveals marked overexpression of interleukin-1-beta, interleukin-10 and interferon-gamma messenger-RNA in the lymph-nodes of lupus-prone mice  Academic Article
• R7BP modulates opiate analgesia and tolerance but not withdrawal  Academic Article
• RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy  Academic Article
• Rapid differential endogenous plasminogen activator expression after acute middle cerebral artery occlusion  Academic Article
• Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting  Academic Article
• Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins  Academic Article
• Rationale for the development of 2-aminobenzamide histone deacetylase inhibitors as therapeutics for Friedreich ataxia  Academic Article
• Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury  Academic Article
• Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model  Academic Article
• Recombinant soluble p-selectin glycoprotein ligand-ig (rpsgl-ig) attenuates infarct size and myeloperoxidase activity in a canine model of ischemia-reperfusion  Academic Article
• Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of schizophrenia  Academic Article
• Reduction in myocardial infarct size by basic fibroblast growth factor following coronary occlusion in a canine model  Academic Article
• Reduction of anxiety after restricted feeding in the rat: Implication for eating disorders  Academic Article
• Reduction of rat myocardial ischemia and reperfusion injury by sialyl lewis x oligosaccharide and anti-rat p-selectin antibodies  Academic Article
• Region-specific changes in the microanatomy of single dendritic spines over time might account for selective memory alterations in ageing hAPPsweTg2576 mice, a mouse model for Alzheimer disease  Academic Article
• Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc  Academic Article
• Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists  Academic Article
• Regulation of immunity by lysosphingolipids and their g protein - coupled receptors  Academic Article
• Regulation of indoleamine 2,3-dioxygenase expression in simian immunodeficiency virus-infected monkey brains  Academic Article
• Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase  Academic Article
• Regulation of macrophage migration by a novel plasminogen receptor Plg-R(KT)  Academic Article
• Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats  Academic Article
• Renal expression of fibrinolytic genes and tissue factor in a murine model of renal disease as a function of age  Academic Article
• Renal response to blood pressure elevation in normal and glomerulonephritic rats  Academic Article
• Replication and transmission of h9n2 influenza viruses in ferrets: Evaluation of pandemic potential  Academic Article
• Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells  Academic Article
• Restenosis - an open file  Academic Article
• Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer  Academic Article
• Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors  Academic Article
• Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging  Academic Article
• Reversal of disease-related pathologies in the fragile x mouse model by selective activation of gaba(b) receptors with arbaclofen  Academic Article
• Reversal of obesity and insulin resistance by a non-peptidic glucagon-like peptide-1 receptor agonist in diet-induced obese mice  Academic Article
• Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway  Academic Article
• Revisiting intragastric ethanol intubation as a dependence induction method for studies of ethanol reward and motivation in rats  Academic Article
• Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease  Academic Article
• Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia  Academic Article
• Role of CCL2/MCP-1 in islet transplantation  Academic Article
• Role of adiponectin and inflammation in insulin resistance of mc3r and mc4r knockout mice  Academic Article
• Role of angiotensin-ii in experimental membranous nephropathy  Academic Article
• Role of lysophosphatidic acid receptor LPA(2) in the development of allergic airway inflammation in a murine model of asthma  Academic Article
• Role of matrix metalloproteinases 2 and 9 in lacrimal gland disease in animal models of Sjogren's syndrome  Academic Article
• Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat  Academic Article
• Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis  Academic Article
• Role of the thymus in murine lupus and cellular transfer of the disease  Academic Article
• Role of viruses in type i diabetes  Academic Article
• S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease  Academic Article
• S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis  Academic Article
• SIRT1 deacetylates RORγt and enhances Th17 cell generation  Academic Article
• Safety assessment of intradiscal gene therapy II - effect of dosing and vector choice  Academic Article
• Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins  Academic Article
• Selective deficits in the expression of striatal-enriched mrnas in huntington's disease  Academic Article
• Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry  Academic Article
• Selective inhibition of factor xa during thrombolytic therapy markedly improves coronary artery patency in a canine model of coronary thrombosis  Academic Article
• Selective mmp-inhibition with ro 28-2653 in acute experimental stroke - a magnetic resonance imaging efficacy study  Academic Article
• Selective reduction of alcohol drinking in sardinian alcohol-preferring rats by a sigma-1 receptor antagonist  Academic Article
• Selective vasopressin-1a receptor antagonist prevents brain edema, reduces astrocytic cell swelling and GFAP, V1aR and AQP4 expression after focal traumatic brain injury  Academic Article
• Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein plus presenilin-1 transgenic mice  Academic Article
• Self-assembling peptide nanofibers coupled with neuropeptide substance P for bone tissue engineering  Academic Article
• Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine  Academic Article
• Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study  Academic Article
• Serine and lipid metabolism in macular disease and peripheral neuropathy  Academic Article
• Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma  Academic Article
• Simian immunodeficiency virus: A model for neuroaids  Academic Article
• Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis  Academic Article
• Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway  Academic Article
• Small animal models for acquired immune deficiency syndrome (AIDS) research  Academic Article
• Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector  Academic Article
• Small molecules affecting transcription in Friedreich ataxia  Academic Article
• Small molecules that protect against β-amyloid-induced cytotoxicity by inhibiting aggregation of β-amyloid  Academic Article
• Sod2 deficient erythroid cells up-regulate transferrin receptor and down-regulate mitochondrial biogenesis and metabolism  Academic Article
• Sos regulatory elements are essential for upec pathogenesis  Academic Article
• Specific macrophage subtypes influence the progression of rhabdomyolysis-induced kidney injury  Academic Article
• Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated akt activation protects against in vivo myocardial ischemia-reperfusion injury  Academic Article
• Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice  Academic Article
• Sphingosine-1-phosphate receptor agonism reduces Bordetella pertussis-mediated lung pathology  Academic Article
• Spine degeneration in a murine model of chronic human tobacco smokers  Academic Article
• Stemming vision loss with stem cells  Academic Article
• Stimulus conditioned to foot-shock stress reinstates alcohol-seeking behavior in an animal model of relapse  Academic Article
• Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy  Academic Article
• Strategies for designing synthetic immune agonists  Academic Article
• Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses  Academic Article
• Stress modulation of drug self-administration: Implications for addiction comorbidity with post-traumatic stress disorder  Academic Article
• Stress, dysregulation of drug reward pathways, and the transition to drug dependence  Academic Article
• Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity  Academic Article
• Structural, functional, and immunogenic insights on Cu,Zn superoxide dismutase pathogenic virulence factors from Neisseria meningitidis and Brucella abortus  Academic Article
• Studies on the protective effect of prostacyclin in acute myocardial ischemia  Academic Article
• Study of lymphocyte subpopulations in bone marrow in a model of protein-energy malnutrition  Academic Article
• Study of the immunopathogenesis of tubulointerstitial nephritis using model systems  Academic Article
• Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior  Academic Article
• Substance dependence as a compulsive behavior  Academic Article
• Successful treatment of the murine model of cystinosis using bone marrow cell transplantation  Academic Article
• Superadditive effects of ethanol and flunitrazepam: Implications of using immunopharmacotherapy as a therapeutic  Academic Article
• Supersensitive endocrine response to physostigmine in dopamine-depleted rats - a model of depression  Academic Article
• Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models  Academic Article
• Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106  Academic Article
• Suppression of colitis in mice by cl-amidine: A novel peptidylarginine deiminase inhibitor  Academic Article
• Suppression of tumor-derived Semaphorin 7A and genetic ablation of host-derived Semaphorin 7A impairs tumor progression in a murine model of advanced breast carcinoma  Academic Article
• Susceptibility of Chinese rhesus monkeys to SIV infection  Academic Article
• Suspension matrices for improved Schwann-cell survival after implantation into the injured rat spinal cord  Academic Article
• Sustained expression of brain-derived neurotrophic factor is required for maintenance of dendritic spines and normal behavior  Academic Article
• Sustained local delivery of dexamethasone by a novel intravascular eluting stent to prevent restenosis in the porcine coronary injury model  Academic Article
• Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleoticle pyrophosphatase phosphodiesterase 1 double-deficient mice  Academic Article
• Switching-on survival and repair response programs in islet transplants by bone marrow-derived vasculogenic cells  Academic Article
• Symmorphosis through dietary regulation: a combinatorial role for proteolysis, autophagy and protein synthesis in normalising muscle metabolism and function of hypertrophic mice after acute starvation  Academic Article
• Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala  Academic Article
• Synthesis and evaluation of analogs of 5 '-(((Z)-4-amino-2-butenyl)methylamino)-5 '-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity  Academic Article
• Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria.  Academic Article
• Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain  Academic Article
• Systemic delivery of NEMO binding domain/IKK gamma inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology  Academic Article
• T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia  Academic Article
• T cell-mediated pathology in murine lyme borreliosis  Academic Article
• T cells in the central nervous system: The delicate balance between viral clearance and disease  Academic Article
• T-cell receptor V-beta-15 dominates the antiacetylcholine receptor response in Lewis rat T-cell lines  Academic Article
• T-cell receptor-v-beta repertoire expression in murine models of sle  Academic Article
• T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification  Academic Article
• TNFR1/phox interaction and TNFR1 mitochondrial translocation Thwart silica-induced pulmonary fibrosis  Academic Article
• TOX3 is expressed in mammary ER(+) epithelial cells and regulates ER target genes in luminal breast cancer  Academic Article
• Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses  Academic Article
• Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation  Academic Article
• Targeting activated integrin alpha v beta 3 with patient-derived antibodies impacts late-stage multiorgan metastasis  Academic Article
• Targeting myelin proteolipid protein to the mhc class i pathway by ubiquitination modulates the course of experimental autoimmune encephalomyelitis  Academic Article
• Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease  Academic Article
• Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease  Academic Article
• Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination  Academic Article
• Temporal requirement for SMN in motoneuron development  Academic Article
• Tentative t cells: Memory cells are quick to respond, but slow to divide  Academic Article
• Terminal deoxynucleotidyl transferase deficiency decreases autoimmune disease in MRL-Fas(lpr) mice  Academic Article
• The 2003 Nicolas Andry Award: Orthopaedic gene therapy  Academic Article
• The 5-HT(7) receptor and disorders of the nervous system: an overview  Academic Article
• The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior  Academic Article
• The 5-HT(7) receptor influences stereotypic behavior in a model of obsessive-compulsive disorder  Academic Article
• The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain  Academic Article
• The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice  Academic Article
• The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates  Academic Article
• The New Zealand black mouse as a model for the development and progression of chronic lymphocytic leukemia  Academic Article
• The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans  Academic Article
• The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids  Academic Article
• The anxiolytic-like effects of the neurosteroid allopregnanolone: Interactions with gaba(a) receptors  Academic Article
• The bicarbonate transporter is essential for bacillus anthracis lethality  Academic Article
• The biology of metastasis to a sanctuary site  Academic Article
• The cell tropism of human immunodeficiency virus type 1 determines the kinetics of plasma viremia in SCID mice reconstituted with human peripheral blood leukocytes  Academic Article
• The chimpanzee model for hepatitis B virus infection  Academic Article
• The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr  Academic Article
• The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs  Academic Article
• The effect of complement depletion on bacterial lipopolysaccharide (LPS)-induced hemodynamic and hematologic changes in the Rhesus monkey  Academic Article
• The effect of glycosaminoglycan loss on chondrocyte viability: a study on porcine cartilage explants  Academic Article
• The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus  Academic Article
• The effect of the phytoestrogen coumestrol on the nzb/w f1 murine model of systemic lupus  Academic Article
• The effects of pharmacological inhibition of histone deacetylase 3 (HDAC3) in Huntington's disease mice  Academic Article
• The first human epitope map of the alphaviral E1 and E2 proteins reveals a new E2 epitope with significant virus neutralizing activity  Academic Article
• The genetics of hypertension  Academic Article
• The glycoprotein precursor gene of Junin virus determines the virulence of the Romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever  Academic Article
• The half-life of hepatitis B virions  Academic Article
• The high degree of sequence plasticity of the arenavirus noncoding intergenic region (IGR) enables the use of a nonviral universal synthetic IGR to attenuate arenaviruses  Academic Article
• The human genome: genetic testing and animal models  Academic Article
• The human retinal degeneration slow (rds) gene - chromosome assignment and structure of the messenger-rna  Academic Article
• The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice 
• The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes  Academic Article
• The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity  Academic Article
• The lysophosphatidic acid receptor lpa(1) promotes epithelial cell apoptosis after lung injury  Academic Article
• The marshall r. Urist young investigator award. Orthopaedic applications of gene therapy. From concept to clinic  Academic Article
• The maternal immune response to fetal platelet GPIb alpha causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies  Academic Article
• The mechanism of molecular redundancy in autoimmune inflammation in the context of CD44 deficiency  Academic Article
• The metabolism of glycosaminoglycans is impaired in prion diseases  Academic Article
• The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity  Academic Article
• The neurobiology of addiction: A neuroadaptational view relevant for diagnosis  Academic Article
• The neurobiology, clinical efficacy and safety of acamprosate in the treatment of alcohol dependence  Academic Article
• The new paradigm of T-cell homeostatic proliferation-induced autoimmunity  Academic Article
• The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme  Academic Article
• The opioid peptides enkephalin and beta-endorphin in alcohol dependence  Academic Article
• The origin and function of soluble cd14 in experimental bacterial meningitis  Academic Article
• The response to burn injury in mice with human hematolymphoid systems  Academic Article
• The restenosis paradigm revisited - an alternative proposal for cellular mechanisms  Academic Article
• The role of complement in experimental disease models  Academic Article
• The role of craving in alcohol use, dependence, and treatment  Academic Article
• The role of nitric oxide in articular cartilage damage  Academic Article
• The role of platelet adhesion receptor GPIb alpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis  Academic Article
• The selective monoacylglycerol lipase inhibitor MJN110 produces opioid-sparing effects in a mouse neuropathic pain model  Academic Article
• The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 attenuates a scopolamine-induced deficit in a novel rodent attention task  Academic Article
• The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking  Academic Article
• The skinny on brain-derived neurotrophic factor: evidence from animal models to GWAS  Academic Article
• The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism  Academic Article
• The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice  Academic Article
• The temporal expression patterns of fibronectin and its receptors-α5β1 and αvβ3 integrins on blood vessels after cerebral ischemia  Academic Article
• The toll of toll-like receptors, especially toll-like receptor 2, on murine atherosclerosis  Academic Article
• The transition from controlled to compulsive drug use is associated with a loss of sensitization  Academic Article
• Theoretical frameworks and mechanistic aspects of alcohol addiction: Alcohol addiction as a reward deficit disorder  Academic Article
• Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models  Academic Article
• Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment  Academic Article
• Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models  Academic Article
• Therapeutic potential of new antiinflammatory drugs  Academic Article
• Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease  Academic Article
• Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption  Academic Article
• Tissue factor contributes to microvascular defects after focal cerebral ischemia  Academic Article
• Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model - studies in tPA-deficient mice and wild-type mice on a matched genetic background  Academic Article
• Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice  Academic Article
• Tissue-specific regulation of p38α-mediated inflammation in Con A-induced acute liver damage  Academic Article
• Tlr2 in murine atherosclerosis  Academic Article
• Tlr4/md-2 monoclonal antibody therapy affords protection in experimental models of septic shock  Academic Article
• Tlrs and ifns: Critical pieces of the autoimmunity puzzle  Academic Article
• Tolerance induction by the blockade of CD40/CD154 interaction in pemphigus vulgaris mouse model  Academic Article
• Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection  Academic Article
• Toll-like receptors and atherosclerosis - key contributors in disease and health?  Academic Article
• Toll-like receptors in atherosclerosis  Academic Article
• Toward an aids vaccine  Academic Article
• Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease  Academic Article
• Transdifferentiation of glioblastoma cells into vascular endothelial cells  Academic Article
• Transfer of a functional human immune system to mice with severe combined immunodeficiency  Academic Article
• Transfer of human chronic lymphocytic leukemia to mice with severe combined immune deficiency  Academic Article
• Transfer of pro alpha 2(i) cdna into cells of a murine model of human osteogenesis imperfecta restores synthesis of type i collagen comprised of alpha 1(i) and alpha 2(i) heterotrimers in vitro and in vivo  Academic Article
• Transgenic mice expressing human hla and cd8 molecules generate hla-restricted measles virus cytotoxic t lymphocytes of the same specificity as humans with natural measles virus infection  Academic Article
• Transmission of prions  Academic Article
• Transplantation of virally transduced cells into the dermis of immunocompetent and immunodeficient (SCID) mice to determine gene expression profile and differential donor cell survival  Academic Article
• Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?  Academic Article
• Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of a beta toxicity  Academic Article
• Transthyretin: The servant of many masters  Academic Article
• Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity  Academic Article
• Treatment of mice with human monoclonal antibody 24 h after lethal aerosol challenge with virulent Venezuelan equine encephalitis virus prevents disease but not infection  Academic Article
• Treatment with lxr agonists after focal cerebral ischemia prevents brain damage  Academic Article
• Tubulointerstitial nephritis induced in the brown norway rat with chaotropically solubilized bovine tubular basement-membrane - the model and the humoral and cellular-responses  Academic Article
• Tumor necrosis factor in mediating experimental hemophilus-influenzae type-b meningitis  Academic Article
• Tumor-targeted il-2 amplifies t cell-mediated immune response induced by gene therapy with single-chain il-12  Academic Article
• Two msbb genes encoding maximal acylation of lipid a are required for invasive shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium  Academic Article
• Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model  Academic Article
• Type I and type II interferon coordinately regulate suppressive dendritic cell fate and function during viral persistence  Academic Article
• Type i interferon during viral infections: Multiple triggers for a multifunctional mediator  Academic Article
• Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris  Academic Article
• Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model  Academic Article
• Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations  Academic Article
• Unravelling the association of partial T-cell immunodeficiency and immune dysregulation  Academic Article
• Upregulation of fibronectin and the α5β1 and αvβ3 integrins on blood vessels within the cerebral ischemic penumbra  Academic Article
• Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior  Academic Article
• Use of a novel mouse genotype to model acute benzodiazepine withdrawal  Academic Article
• Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model  Academic Article
• Using transgenic mouse models to dissect the pathogenesis of virus-induced autoimmune disorders of the islets of langerhans and the central nervous system  Academic Article
• Utility of genetically modified mice for understanding the neurobiology of substance use disorders  Academic Article
• VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice  Academic Article
• VBP15, a novel dissociative steroid compound, reduces NFκB-induced expression of inflammatory cytokines in vitro and symptoms of murine trinitrobenzene sulfonic acid-induced colitis  Academic Article
• Vaccination against tie2 reduces atherosclerosis  Academic Article
• Vascular remodeling underlies rebleeding in hemophilic arthropathy  Academic Article
• Viral persistence: Parameters, mechanisms and future predictions  Academic Article
• Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis  Academic Article
• Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and multiple sclerosis  Academic Article
• Virus-induced diabetes in a transgenic model: Role of cross-reacting viruses and quantitation of effector t cells needed to cause disease  Academic Article
• Volumetric evaluation of the ischemic lesion size with serial mri in a transient mcao model of the rat: Comparison of dwi and t1wi  Academic Article
• Whither or wither microbicides?  Academic Article
• Whole animal section insitu hybridization and protein blotting - new tools in molecular analysis of animal-models for human-disease  Academic Article
• Why are some amyloidoses systemic? Does hepatic "chaperoning at a distance" prevent cardiac deposition in a transgenic model of human senile systemic (transthyretin) amyloidosis?  Academic Article
• X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C  Academic Article
• Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone BXSB mice  Academic Article
• Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice  Academic Article
• [HIV glycoprotein 120: possible etiological agent of AIDS-associated dementia] [Article in Spanish]  Academic Article
• betaCaMKII in lateral habenula mediates core symptoms of depression  Academic Article
• gp120 and neurotoxicity in vivo  Academic Article
• hu-PBL-SCID mice: a model for human immune function, AIDS, and lymphomagenesis  Academic Article
• von Willebrand's disease  Academic Article