Disease Models, Animal

subject area of

-Amino acid substitution of peptide-mediated NF-κB suppression in mdx mice preserves therapeutic benefit in skeletal muscle, but causes kidney toxicity Academic Article
4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency Academic Article
5-HT(7) receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern Academic Article
5-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity Academic Article
7-nitroindazole, nitric oxide synthase inhibitor, attenuates physical dependence on butorphanol in rat Academic Article
A Bellagio consensus. Children's Vaccine Initiative Ad Hoc Committe on an investment strategy for measles control Academic Article
A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice Academic Article
A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model Academic Article
A blueprint for HIV vaccine discovery Academic Article
A broadly neutralizing human monoclonal antibody exhibits in vivo efficacy against both human metapneumovirus and respiratory syncytial virus Academic Article
A candidate circuit approach to investigating autism Academic Article
A cellular mechanism for dendritic spine loss in the pilocarpine model of status epilepticus Academic Article
A chimeric mouse model of Gaucher disease Academic Article
A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models Academic Article
A critical role for the sphingosine analog aal-r in dampening the cytokine response during influenza virus infection Academic Article
A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics Academic Article
A dystroglycan mutation associated with limb-girdle muscular dystrophy Academic Article
A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function Academic Article
A genetic analysis of lupus Academic Article
A genetically humanized mouse model for hepatitis C virus infection Academic Article
A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis Academic Article
A human recombinant monoclonal antibody to cocaine: preparation, characterization and behavioral studies Academic Article
A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis Academic Article
A liver-selective LXR inverse agonist that suppresses hepatic steatosis Academic Article
A model for familial exudative vitreoretinopathy caused by LPR5 mutations Academic Article
A mouse model for nonsyndromic deafness (dfnb12) links hearing loss to defects in tip links of mechanosensory hair cells Academic Article
A mouse model of accelerated liver aging caused by a defect in DNA repair Academic Article
A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice Academic Article
A multifunctional bispecific antibody protects against Pseudomonas aeruginosa Academic Article
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response Academic Article
A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis Academic Article
A novel generation of heparan sulfate mimetics for the treatment of prion diseases Academic Article
A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease Academic Article
A novel synthetic bipartite carrier protein for developing glycotope-based vaccines Academic Article
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects Academic Article
A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice Academic Article
A plaque-specific antibody clears existing beta-amyloid plaques in Alzheimer's disease mice Academic Article
A putative bacterial ABC transporter circumvents the essentiality of signal peptidase Academic Article
A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome Academic Article
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition Academic Article
A stem cell-based approach to cartilage repair Academic Article
A synthetic tlr4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease Academic Article
A transgenic mouse model for measles virus infection of the brain Academic Article
A transgenic mouse model of the chronic hepatitis B surface antigen carrier state Academic Article
A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates Academic Article
A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes Academic Article
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC Academic Article
Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss Academic Article
Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model Academic Article
Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via Fc gamma RIIb on Liver Sinusoidal Endothelial Cells by Endocytosis Academic Article
Accelerated aging of intervertebral discs in a mouse model of progeria Academic Article
Accelerating next-generation vaccine development for global disease prevention Academic Article
Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects Academic Article
Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo Academic Article
Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1 Academic Article
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells Academic Article
Activation of HIPK2 promotes ER stress-mediated neurodegeneration in amyotrophic lateral sclerosis Academic Article
Activation of brain NOP receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat Academic Article
Activation of lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury Academic Article
Activation of p38α in T cells regulates the intestinal host defense against attaching and effacing bacterial infections Academic Article
Activation of the liver x receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy Academic Article
Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: a potential therapeutic target Academic Article
Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats Academic Article
Activity of hoechst 33258 against Pneumocystis carinii f. sp muris, Candida albicans, and Candida dubliniensis Academic Article
Acute immunologic arthritis in rabbits Academic Article
Adaptation of energy metabolism in breast cancer brain metastases Academic Article
Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-- Jakob disease: implications for human health Academic Article
Adaptation, allometry, and hypertension Academic Article
Additive effect of stress and drug cues on reinstatement of ethanol seeking: Exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms Academic Article
Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway Academic Article
Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary-artery model Academic Article
Administration of recombinant p-selectin glycoprotein ligand fc fusion protein suppresses inflammation and neointimal formation in zucker diabetic rat model Academic Article
Adoptive transfer of human lymphoid cells to severely immunodeficient mice: models for normal human immune function, autoimmunity, lymphomagenesis, and AIDS Academic Article
Adult CST-null mice maintain an increased number of oligodendrocytes Academic Article
Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees Academic Article
Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state Academic Article
Alcohol-related genes: Contributions from studies with genetically engineered mice Academic Article
Alcoholism: Allostasis and beyond Academic Article
Alteration of intracerebral cytokine production in mice infected with herpes-simplex virus type-1 and type-2 Academic Article
Alteration of methamphetamine-induced stereotypic behaviour in transgenic mice expressing hiv-1 envelope protein gp120 Academic Article
Alterations in spinal cord metabolism during treatment of neuropathic pain Academic Article
Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor Academic Article
Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model Academic Article
Amelioration of chronic murine colitis by peptide-mediated transduction of the I kappa B kinase inhibitor NEMO binding domain peptide Academic Article
Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma Academic Article
Aminostyrylbenzofuran directly reduces oligomeric amyloid-β and reverses cognitive deficits in Alzheimer transgenic mice Academic Article
Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD Academic Article
Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: A possible model for senile systemic amyloidosis Academic Article
Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model Academic Article
An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides Academic Article
An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model Academic Article
An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages Academic Article
An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy Academic Article
An animal-model to study serum immunoglobulin response to infection by Yersinia-entercocolitica Academic Article
An autosomal recessive gene that delays expression of lupus in bxsb mice Academic Article
An epigenetic blockade of cognitive functions in the neurodegenerating brain Academic Article
An evaluation of the development of experimental membranous nephropathy Academic Article
An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints Academic Article
Analysis of t-cell function in autoimmune murine strains - defects in production of and responsiveness to interleukin-2 Academic Article
Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo Academic Article
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase Academic Article
Androgen receptor splice variants determine taxane sensitivity in prostate cancer Academic Article
Animal model of respiratory syncytial virus: CD8(+) T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy Academic Article
Animal models for retrovirus-induced immunodeficiency disease Academic Article
Animal models in dengue Academic Article
Animal models of craving for ethanol Academic Article
Animal models of craving: a roundtable discussion Academic Article
Animal models of human amyloidoses: Are transgenic mice worth the time and trouble? Academic Article
Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology Academic Article
Animal models used to examine the role of the environment in the development of autoimmune disease: Findings from an NIEHS Expert Panel Workshop Academic Article
Animal-models of drug craving Academic Article
Anti-cd11b antibody prevents immunopathologic changes in viable moth-eaten bone-marrow chimeric mice Academic Article
Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones Academic Article
Anti-inflammatory activity of superoxide dismutase obtained from Debaryomyces hansenii on type II collagen induced arthritis in rats Academic Article
Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke Academic Article
Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma Academic Article
Antibodies against cd14 protect primates from endotoxin-induced shock Academic Article
Antibody SPC-54 provides acute in vivo blockage of the murine protein C system Academic Article
Antibody neutralization-resistant primary isolates of human immunodeficiency virus type 1 Academic Article
Antibody responses to envelope glycoproteins in HIV-1 infection Academic Article
Antibody-il-12 fusion proteins are effective in scid mouse models of prostate and colon carcinoma metastases Academic Article
Anticonvulsant activity of a nonpeptide galanin receptor agonist Academic Article
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation Academic Article
Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress Academic Article
Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978 Academic Article
Antithrombotic activity of protein S infused without activated protein C in a baboon thrombosis model Academic Article
Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models Academic Article
Application of genomics to toxicology research Academic Article
Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor Academic Article
Arenavirus genetic diversity and its biological implications Academic Article
Arenavirus genome rearrangement for the development of live attenuated vaccines Academic Article
Arginine 54 and tyrosine 118 residues of αA-crystallin are crucial for lens formation and transparency Academic Article
Association of cartilage-specific deletion of peroxisome proliferator-activated receptor gamma with abnormal endochondral ossification and impaired cartilage growth and development in a murine model Academic Article
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina Academic Article
Attenuation of allergic contact dermatitis through the endocannabinoid system Academic Article
Attenuation of cue-induced heroin-seeking behavior by cannabinoid CB(1) antagonist infusions into the nucleus accumbens core and prefrontal cortex, but not basolateral amygdala Academic Article
Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: Involvement of regulatory T cells Academic Article
Autoantibodies to gpi in rheumatoid arthritis: Linkage between an animal model and human disease Academic Article
Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients Academic Article
Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice Academic Article
Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation Academic Article
B-cell-tropic interleukins in murine systemic lupus-erythematosus (sle)-1 Academic Article
BAG1 over-expression in brain protects against stroke Academic Article
BCL-2 in prostate cancer: A minireview Academic Article
BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice Academic Article
Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid. Academic Article
Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy Academic Article
Basic science of intra-articular fractures and posttraumatic osteoarthritis Academic Article
Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells Academic Article
Behavioral, biological, and chemical perspectives on targeting crf1 receptor antagonists to treat alcoholism Academic Article
Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): Efficacy in an animal model for schizophrenia Academic Article
Benzoxazolinone aryl sulfonamides as potent, selective Na(v)1.7 inhibitors with in vivo efficacy in a preclinical pain model Academic Article
Beta 1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex Academic Article
Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis Academic Article
Binding of soluble immune complexes to human lymphoblastoid cells. Ii. Use of raji cells to detect circulating immune complexes in animal and human sera Academic Article
Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection Academic Article
Biology and pathogenesis of lymphocytic choriomeningitis virus infection Academic Article
Biphasic alterations in serotonin-1B (5-HT1B) receptor function during abstinence from extended cocaine self-administration Academic Article
Blockade of hypocretin receptor-1 preferentially prevents cocaine seeking: comparison with natural reward seeking Academic Article
Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection Academic Article
Blockade of the platelet p2y(12) receptor by ar-c69931mx sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis model Academic Article
Bornavirus and the brain Academic Article
Brain disease model of addiction: why is it so controversial? Academic Article
Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury Academic Article
Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice Academic Article
Bronchoalveolar lavage with KL4-Surfactant in models of meconium aspiration syndrome Academic Article
CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120 Academic Article
CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection. Academic Article
Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain Academic Article
Can a single subunit yeast nadh dehydrogenase (ndi1) remedy diseases caused by respiratory complex i defects? Academic Article
Cancer-specific mutations in PIK3CA are oncogenic in vivo Academic Article
Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: An expanded convergent functional genomics approach Academic Article
Carboxyfullerene neuroprotection postinjury in Parkinsonian nonhuman primates Academic Article
Cellular and behavioral interactions of gabapentin with alcohol dependence Academic Article
Cellular events associated with immunogenesis of anti-erythrocyte autoantibody responses of nzb mice Academic Article
Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics Academic Article
Central nervous system (cns)-resident natural killer cells suppress th17 responses and cns autoimmune pathology Academic Article
Central nervous system infection with Borna disease virus causes kynurenine pathway dysregulation and neurotoxic quinolinic acid production Academic Article
Centrally administered urocortin 2 decreases gorging on high-fat diet in both diet-induced obesity-prone and -resistant rats Academic Article
Changes in locomotor response to beta-endorphin microinfusion during and after opiate abstinence syndrome - a proposal for a model of the onset of mania Academic Article
Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse Academic Article
Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. Academic Article
Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin Academic Article
Characterization of a side population of astrocytoma cells in response to temozolomide Academic Article
Characterization of cytokine and inos mrna expression in situ during the course of experimental autoimmune myocarditis in rats Academic Article
Characterization of mouse mutants with abnormal RPE cells Academic Article
Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain Academic Article
Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels Academic Article
Chemical probes of endocannabinoid metabolism Academic Article
Chemoproteomic profiling of host and pathogen enzymes active in cholera Academic Article
Chick embryo chorioallantoic membrane models to quantify angiogenesis induced by inflammatory and tumor cells or purified effector molecules Academic Article
Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes Academic Article
Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test Academic Article
Chronic alcohol consumption generates a vulnerable immune environment during early SIV infection in rhesus macaques Academic Article
Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking Academic Article
Chronic periadolescent alcohol consumption produces persistent cognitive deficits in rhesus macaques Academic Article
Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure Academic Article
Chronic wasting disease of deer and elk in transgenic mice: Oral transmission and pathobiology Academic Article
Chronic wheel running reduces maladaptive patterns of methamphetamine intake: Regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase Academic Article
Circadian physiology of metabolism Academic Article
Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints Academic Article
Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis Academic Article
Clinical features of bacterial vaginosis in a murine model of vaginal infection with Gardnerella vaginalis Academic Article
Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors Academic Article
Combination angiostatic therapies: targeting multiple angiogenic pathways Academic Article
Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma Academic Article
Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models Academic Article
Common genetic mechanisms of blood pressure elevation in two independent rodent models of human essential hypertension Academic Article
Comparative analysis of metastasis variants derived from human prostate carcinoma cells: roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion Academic Article
Comparative immunological analysis of several murine strains with autoimmune manifestations Academic Article
Comparison of mice with accelerated aging caused by distinct mechanisms Academic Article
Completion of the entire hepatitis C virus life cycle in genetically humanized mice Academic Article
Complex I inhibition in the visual pathway induces disorganization of the node of Ranvier Academic Article
Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors Academic Article
Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems Academic Article
Conditioned withdrawal drives heroin consumption and decreases reward sensitivity Academic Article
Connexin mediated cataract prevention in mice Academic Article
Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis Academic Article
Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility Academic Article
Contribution of spinal 5-ht1a and 5-ht7 receptors to locomotor-like movement induced by 8-oh-dpat in spinal cord-transected mice Academic Article
Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors Academic Article
Convergent functional genomic studies of omega-3 fatty acids in stress reactivity, bipolar disorder and alcoholism Academic Article
Convergent functional genomics of anxiety disorders: Translational identification of genes, biomarkers, pathways and mechanisms Academic Article
Convergent functional genomics of bipolar disorder: From animal model pharmacogenomics to human genetics and biomarkers Academic Article
Convergent functional genomics of psychiatric disorders Academic Article
Convergent functional genomics of schizophrenia: From comprehensive understanding to genetic risk prediction Academic Article
Convergent functional genomics: a Bayesian candidate gene identification approach for complex disorders Academic Article
Convergent integration of animal model and human studies of bipolar disorder (manic-depressive illness) Academic Article
Conversion of human fibroblasts into functional cardiomyocytes by small molecules Academic Article
Conversion of human fibroblasts to functional endothelial cells by defined factors Academic Article
Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model Academic Article
Cortical neuronal cytoskeletal changes associated with fiv infection Academic Article
Corticotropin-releasing factor (CRF) and alpha 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats Academic Article
Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats Academic Article
Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection Academic Article
Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal CNS Academic Article
Critical role of transmethylation in TLR signaling and systemic lupus erythematosus Academic Article
Cross-reactive and potent neutralizing antibody responses in human survivors of natural Ebolavirus infection Academic Article
Crystallin gamma B-I4F mutant protein binds to alpha-crystallin and affects lens transparency Academic Article
Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide Academic Article
Cytoplasmic extracts from adipose tissue stromal cells alleviates secondary damage by modulating apoptosis and promotes functional recovery following spinal cord injury Academic Article
Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa-induced lung injury in mice Academic Article
DISC1 regulates trafficking and processing of APP and Aβ generation Academic Article
DNA vaccination against vegf receptor 2 reduces atherosclerosis in ldl receptor-deficient mice Academic Article
DNA vaccination can break immunological tolerance to prp in wild-type mice and attenuates prion disease after intracerebral challenge Academic Article
Daring to learn from humanized mice Academic Article
Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice Academic Article
Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders Academic Article
Defects in skin γδ T cell function contribute to delayed wound repair in rapamycin-treated mice Academic Article
Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances Academic Article
Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model Academic Article
Deficiency of the cyclin kinase inhibitor P21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoirnmunity Academic Article
Defining parameters for successful immunocytotherapy of persistent viral infection Academic Article
Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis Academic Article
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms Academic Article
Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin Academic Article
Dense nuclear cataract caused by the γB-crystallin S11R point mutation Academic Article
Dentate gyrus volume is reduced before onset of plaque formation in pdapp mice: A magnetic resonance microscopy and stereologic analysis Academic Article
Dependence-induced alcohol drinking by alcohol-preferring (p) rats and outbred wistar rats Academic Article
Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease Academic Article
Design, synthesis and SAR of novel glucokinase activators Academic Article
Determination of enzymatic source of alanine aminotransferase activity in serum from dogs with liver injury Academic Article
Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection Academic Article
Development of a novel vaccine containing binary toxin for the prevention of clostridium difficile disease with enhanced efficacy against NAP1 strains Academic Article
Development of approaches to improve cell survival in myoblast transfer therapy Academic Article
Development of live-attenuated arenavirus vaccines based on codon deoptimization Academic Article
Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming inDrosophila Academic Article
Diabetes insipidus in mice with a mutation in aquaporin-2 Academic Article
Didehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic mice Academic Article
Different mechanisms of increased luminal stenosis after arterial injury in mice deficient for urokinase- or tissue-type plasminogen activator Academic Article
Differential effects of acute alcohol on prepulse inhibition and event-related potentials in adolescent and adult Wistar rats Academic Article
Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy Academic Article
Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia. Academic Article
Differential role of melanocortin receptor subtypes in cachexia Academic Article
Diffuse lung disease in children: summary of a scientific conference Academic Article
Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model Academic Article
Discovering disease-associated enzymes by proteome reactivity profiling Academic Article
Discovery and optimization of a series of pyrimidine-based phosphodiesterase 10A (PDE10A) inhibitors through fragment screening, structure-based design, and parallel synthesis Academic Article
Discovery of 5-aryl-1,3-dihydro-2H-imidazo 4,5-b pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis Academic Article
Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition Academic Article
Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements Academic Article
Discovery of novel drugs for promising targets Academic Article
Discovery of potent and bioavailable GSK-3β inhibitors Academic Article
Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model Academic Article
Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na(v)1.7 inhibitors with pain efficacy in mice Academic Article
Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis Academic Article
Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal Academic Article
Distinct antithrombotic consequences of platelet glycoprotein Ibα and VI deficiency in a mouse model of arterial thrombosis Academic Article
Distinct patterns of neural activation associated with ethanol seeking: Effects of naltrexone Academic Article
Divergent anatomical pattern of d-1 and d-3 binding and dopamine- and cyclic amp-regulated phosphoprotein of 32 kda mrna expression in the roman rat strains: Implications for drug addiction Academic Article
Dna immunization and central nervous system viral infection Academic Article
Dominant cataracts result from incongruous mixing of wild-type lens connexins Academic Article
Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy Academic Article
Dopamine d2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats Academic Article
Dorsal as well as ventral striatal lesions affect levels of intravenous cocaine and morphine self-administration in rats Academic Article
Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats Academic Article
Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils Academic Article
Dramatic decreases in brain reward function during nicotine withdrawal Academic Article
Drug dependence: Stress and dysregulation of brain reward pathways Academic Article
Drug target validation: lethal infection blocked by inducible peptide Academic Article
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis Academic Article
Dysfunctional gamma delta t cells contribute to impaired keratinocyte homeostasis in mouse models of obesity Academic Article
EEG and ERP profiles in the high alcohol preferring (HAP) and low alcohol preferring (LAP) mice: Relationship to ethanol preference Academic Article
EPHA2 is associated with age-related cortical cataract in mice and humans Academic Article
EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques Academic Article
ERK regulation in chronic ethanol exposure and withdrawal Academic Article
Early dysfunction of central 5-HT system in a murine model of bovine spongiform encephalopathy Academic Article
Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats Academic Article
Early spontaneous metastasis in the human epidermoid carcinoma hep3-chick embryo model - contribution of incidental colonization Academic Article
Early-onset behavioral and synaptic deficits in a mouse model of alzheimer's disease Academic Article
EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin Academic Article
Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease Academic Article
Editorial overview: Viral pathogenesis Academic Article
Effect of amrinone on tumor necrosis factor production in endotoxic shock Academic Article
Effect of aripiprazole, a partial dopamine d-2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration Academic Article
Effect of chronic hypoxia on detoxication enzymes in rat liver Academic Article
Effect of complement depletion on experimental tissue injury Academic Article
Effect of experimental cerebral infarction in rat-brain on catecholamines and behavior Academic Article
Effect of hyperhomocysteinemia on protein C activation and activity Academic Article
Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus Academic Article
Effect of sigma(1) receptor antagonism on ethanol and natural reward seeking Academic Article
Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen Academic Article
Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy Academic Article
Effective therapy of the LP-BM5 murine retrovirus-induced lymphoproliferative immunodeficiency disease with diethyldithiocarbamate Academic Article
Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL Academic Article
Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4 Academic Article
Effects of a SARS-associated coronavirus vaccine in monkeys Academic Article
Effects of cb1 and crf1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: Lack of withdrawal-like responses Academic Article
Effects of chronic overexpression of interleukin-1 receptor antagonist in a model of permanent focal cerebral ischemia in mouse Academic Article
Effects of crf(1)-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (p) rats Academic Article
Effects of cytokine gene therapy on particulate-induced inflammation in the murine air pouch Academic Article
Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats Academic Article
Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence Academic Article
Effects of topical Janus kinase inhibition on ocular surface inflammation and immunity Academic Article
Efficacy of synthetic peptide-containing surfactant in the treatment of respiratory distress syndrome in preterm infant rhesus monkeys Academic Article
Efficacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice Academic Article
Electrophysiological and cerebrovascular effects of the α-secretase-derived form of amyloid precursor protein in young and middle-aged rats Academic Article
Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression Academic Article
Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation Academic Article
Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma Academic Article
Embryonic senescence and laminopathies in a progeroid zebrafish model Academic Article
Endocannabinoid metabolism and transport as targets to regulate intraocular pressure Academic Article
Endocannabinoid regulation of amyloid-induced neuroinflammation Academic Article
Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies Academic Article
Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Academic Article
Endothelial protein C receptor function in murine and human breast cancer development Academic Article
Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease Academic Article
Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice Academic Article
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P(1) antagonist in vivo Academic Article
Enhancement of experimental allergic encephalomyelitis (eae) by DNA immunization with myelin proteolipid protein (plp) plasmid DNA Academic Article
Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells Academic Article
Envelope exchange for the generation of live-attenuated arenavirus vaccines Academic Article
Epilepsy, cns viral injury and dynorphin Academic Article
Epstein-Barr virus-induced human B-cell lymphomas in SCID mice reconstituted with human peripheral blood leukocytes Academic Article
Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders Academic Article
Escalating morphine exposures followed by withdrawal in feline immunodeficiency virus-infected cats: a model for HIV infection in chronic opiate abusers Academic Article
Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels Academic Article
Escalation of drug self-administration as a hallmark of persistent addiction liability Academic Article
Escalation patterns of varying periods of heroin access Academic Article
Etiopathogenesis of murine sle Academic Article
Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality Academic Article
Evaluation of fatty acid amides in the carrageenan-induced paw edema model Academic Article
Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants Academic Article
Evaluation of metastatic and angiogenic potentials of human colon carcinoma cells in chick embryo model systems Academic Article
Evaluation of the echinocandin antifungal mk-0991 (l-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis Academic Article
Event-related oscillations as risk markers in genetic mouse models of high alcohol preference Academic Article
Evidence for genetic association of RORB with bipolar disorder Academic Article
Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice Academic Article
Evidence that the hypermutated m protein of a subacute sclerosing panencephalitis measles virus actively contributes to the chronic progressive cns disease Academic Article
Evidence that vasopressin V(1b) receptors mediate the transition to excessive drinking in ethanol-dependent rats Academic Article
Ex vivo gene delivery of il-1ra and soluble tnf receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis Academic Article
Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation Academic Article
Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA Academic Article
Exosomes derived from genetically modified dc expressing fasl are anti-inflammatory and immunosuppressive Academic Article
Experimental glomerulonephritis induced by in situ formation of immune-complexes in glomerular capillary wall Academic Article
Experimental psychiatric illness and drug abuse models: from human to animal, an overview Academic Article
Experimental renal disease induced by DNA-anti-DNA immune complexes Academic Article
Experimental skin lesions in mice resembling systemic lupus erythematosus Academic Article
Experimental-models of coronary-artery restenosis Academic Article
Exposure of neonatal rats to alcohol by vapor inhalation demonstrates specificity of microcephaly and purkinje-cell loss but not astrogliosis Academic Article
Expression of type 1 plasminogen activator inhibitor in renal tissue in murine lupus nephritis Academic Article
Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments Academic Article
Extensive cell migration, axon regeneration, and improved function with polysialic acid-modified Schwann cells after spinal cord injury Academic Article
Extracellular-matrix accumulation in immune-mediated tubulointerstitial injury Academic Article
Extremely potent human monoclonal antibodies from COVID-19 convalescent patients Academic Article
FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation Academic Article
FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination Academic Article
FXa takes center stage in vascular inflammation Academic Article
Facilitation of spike-wave discharge activity by lipopolysaccharides in Wistar Albino Glaxo/Rijswijk rats Academic Article
Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation Academic Article
Failure of heparin to affect 2 types of experimental glomerulonephritis in rabbits Academic Article
Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice Academic Article
Fatty acid amide hydrolase deficiency limits early pregnancy events Academic Article
Feeding microstructure in diet-induced obesity susceptible versus resistant rats: Central effects of urocortin 2 Academic Article
Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV Academic Article
Feline immunodeficiency virus as a model for study of lentivirus infection of the central nervous system Academic Article
First-in-class inhibitors of sulfur metabolism with bactericidal activity against non-replicating M. tuberculosis Academic Article
Fluorescent histochemical study of changes in noradrenergic neurons following experimental cerebral infarction in rat Academic Article
Forkhead box protein p1 is a transcriptional repressor of immune signaling in the cns: Implications for transcriptional dysregulation in huntington disease Academic Article
Formation of gelsolin amyloid fibrils in the rough endoplasmic reticulum of skeletal muscle in the gelsolin mouse model of inclusion body myositis: comparative analysis to human sporadic inclusion body myositis Academic Article
Frequent exposure of mice to crude Brucella abortus proteins down-regulates immune response Academic Article
Functional interaction between opioid and cannabinoid receptors in drug self-administration Academic Article
Functional recovery after embolic stroke in rodents by activated protein C Academic Article
Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination Academic Article
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease Academic Article
GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes Academic Article
GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models Academic Article
Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5 Academic Article
Gamma delta t cells are reduced and rendered unresponsive by hyperglycemia and chronic tnf alpha in mouse models of obesity and metabolic disease Academic Article
Gamma delta t cells in host defense and epithelial cell biology Academic Article
Gender differences in autoimmunity associated with exposure to environmental factors Academic Article
Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats Academic Article
Gene therapy for autoimmune disorders Academic Article
Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4 Academic Article
Gene therapy for osteoporosis: Evaluation in a murine ovariectomy model Academic Article
Gene therapy for rheumatoid arthritis Academic Article
Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCIS mouse model Academic Article
Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes Academic Article
Generation and analysis of an rna vaccine that protects against coxsackievirus b3 challenge Academic Article
Generation and phenotypic analysis of protein S-deficient mice Academic Article
Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome Academic Article
Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest Academic Article
Genetic deficiency in pparg does not alter development of experimental prostate cancer Academic Article
Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis Academic Article
Genetic dissection of innate immunity to infection: The mouse cytomegalovirus model Academic Article
Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat Academic Article
Genetic risk prediction and neurobiological understanding of alcoholism Academic Article
Genetical genomic determinants of alcohol consumption in rats and humans Academic Article
Genetics of SLE in mice Academic Article
Genetics of systemic autoimmunity and glomerulonephritis in mouse models of lupus Academic Article
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii Academic Article
Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates alzheimer's disease-related neuropathies: Involvement of non-amyloidogenic processing Academic Article
Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex Academic Article
Glomerular antigens in glomerulonephritis Academic Article
Glomerular effects of pregnancy in a model of glomerulonephritis in the rat Academic Article
Glomerular extracellular matrix accumulation in experimental anti-GEM Ab glomerulonephritis Academic Article
Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease Academic Article
Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat Academic Article
HBV pathogenesis in animal models: recent advances on the role of platelets Academic Article
HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation Academic Article
HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model Academic Article
HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria Academic Article
Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone Academic Article
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells Academic Article
Hematopoietic stem cell gene therapy for the multisystemic lysosomal storage disorder cystinosis Academic Article
Hemostatic gene expression and vascular disease in obesity: insights from studies of genetically obese mice Academic Article
Hepatitis B virus structure and biology Academic Article
Hepatitis B virus transgenic mice: Models of viral immunobiology and pathogenesis Academic Article
Heregulin-ErbB3-driven tumor growth persists in PI3 kinase mutant cancer cells Academic Article
Heterogeneity of Alcohol Use Disorder: Understanding Mechanisms to Advance Personalized Treatment Academic Article
Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice Academic Article
High-resolution mutational profiling suggests the genetic validity of glioblastoma patient-derived pre-clinical models Academic Article
High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations Academic Article
Highly potent RANTES analogues either prevent CCR5-using human immunodeficiency virus type 1 infection in vivo or rapidly select for CXCR4-using variants Academic Article
Hippocampal and septal injections of nicotine and 8-oh-dpat distinguish among different animal tests of anxiety Academic Article
Hippocampal neurogenesis protects against cocaine-primed relapse Academic Article
Histone H2A-mediated transient cytokine gene delivery induces efficient antitumor responses in murine neuroblastoma Academic Article
Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of huntington's disease Academic Article
Histone deacetylase inhibitor suppression of auto antibody-mediated arthritis in mice via regulation of p16(INK4a) and p21(WAF1/Cip1) expression Academic Article
Histone posttranslational modifications in schizophrenia Academic Article
HlF-2 alpha deletion promotes kras-driven lung tumor development Academic Article
Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-Induced Osteolysis and Reduces Overall Survival Academic Article
Human CD22 inhibits murine B cell receptor activation in a human CD22 transgenic mouse model Academic Article
Human immunodeficiency virus infection of human-PBL-SCID mice Academic Article
Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment Academic Article
Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes Academic Article
Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis Academic Article
Human periprosthetic tissues implanted in severe combined immunodeficient mice respond to gene transfer of a cytokine inhibitor Academic Article
Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis Academic Article
Human xenograft models for virus infection Academic Article
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1 Academic Article
Hydrodynamic injection of viral DNA: A mouse model of acute hepatitis B virus infection Academic Article
Hyperoncotic albumin infusion in experimental glomerulonephritis in rats - micropuncture study Academic Article
Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger Academic Article
Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats Academic Article
ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus Academic Article
ICOS-dependent extrafollicular helper T cells elicit igg production via IL-21 in systemic autoimmunity Academic Article
IKK beta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis Academic Article
IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects Academic Article
IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms Academic Article
IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice Academic Article
IP3 3-kinase B prevents bone marrow failure Academic Article
Id2 is dispensable for myc-induced lymphomagenesis Academic Article
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection Academic Article
Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach Academic Article
Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9 Academic Article
Identifying the long-term role of inducible nitric oxide synthase after contusive spinal cord injury using a transgenic mouse model Academic Article
Ifit1 protects against lipopolysaccharide and D-galactosamine-induced fatal hepatitis by inhibiting activation of the JNK Pathway Academic Article
IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model Academic Article
Il-5 links adaptive and natural immunity specific for epitopes of oxidized ldl and protects from atherosclerosis Academic Article
Imaging androgen receptor signaling with a radiotracer targeting free prostate-specific antigen Academic Article
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis Academic Article
Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models Academic Article
Immune aspects of renal diseases Academic Article
Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus Academic Article
Immunocytokines: A promising approach to cancer immunotherapy Academic Article
Immunodeficient mice xenografted with human lymphoid cells: new models for in vivo studies of human immunobiology and infectious diseases Academic Article
Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris Academic Article
Immunopathogenicity and oncogenicity of murine leukemia viruses. I. Induction of immunologic disease and lymphoma in (balb-c times nzb)f1 mice by scripps leukemia virus Academic Article
Immunopathology and pathogenesis of cutaneous involvement in systemic lupus erythematosus Academic Article
Immunopathology during coxsackievirus infection Academic Article
Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection Academic Article
Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases Academic Article
Improving the pharmacokinetic and CYP inhibition profiles of azaxanthene-based glucocorticoid receptor modulators-identification of (S)-5-(2-(9-fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5H-chromeno[2,3-b]pyridin-5-yl)-2-methylpropanamido)-N-(tetrahydro-2H-pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide (BMS-341) Academic Article
In a transgenic model of spontaneous autoimmune diabetes, expression of a protective class II MHC molecule results in thymic deletion of diabetogenic CD8+ T cells Academic Article
In the hypoxic central nervous system, endothelial cell proliferation is followed by astrocyte activation, proliferation, and increased expression of the alpha 6 beta 4 integrin and dystroglycan Academic Article
In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi Academic Article
In vivo ablation of type I interferon receptor from cardiomyocytes delays coxsackieviral clearance and accelerates myocardial disease Academic Article
In vivo and in vitro production of anti-histone antibodies in NZB/NZW mice Academic Article
In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons Academic Article
In vivo complementation of complex i by the yeast ndi1 enzyme - possible application for treatment of parkinson disease Academic Article
In vivo potent BM635 analogue with improved drug-like properties Academic Article
In vivo treatment with a mhc class i-restricted blocking peptide can prevent virus-induced autoimmune diabetes Academic Article
Increase of anti-metastatic efficacy by selectivity-but not affinity-optimization of synthetic serine protease inhibitors Academic Article
Increased c-fos expression in the central nucleus of the amygdala and enhancement of cued fear memory in dyt1 delta gag knock-in mice Academic Article
Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction Academic Article
Increased expression of thrombospondin-1 in vessel wall of diabetic zucker rat Academic Article
Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase Academic Article
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation Academic Article
Induction of a protective immune response against viral nervous necrosis in the european sea bass dicentrarchus labrax by using betanodavirus virus-like particles Academic Article
Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded microRNA-15a Academic Article
Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3 Academic Article
Induction, characterization, and cell transfer of autoimmune tubulointerstitial nephritis Academic Article
Infection of cats with molecularly cloned and biological isolates of the feline immunodeficiency virus Academic Article
Infection with MERS-CoV causes lethal pneumonia in the common marmoset Academic Article
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity Academic Article
Inflammatory cytokines: Putative regulators of neuronal and neuro-endocrine function Academic Article
Influence of cortisone on seizure activity in Papio-papio model of epilepsy Academic Article
Influence of local delivery of the protein tyrosine kinase receptor inhibitor tyrphostin-47 on smooth-muscle cell proliferation in a rat carotid balloon-injury model Academic Article
Influence of thymic genotype on the systemic lupus erythematosus-like disease and t-cell proliferation of mrl-mp-lpr-lpr mice Academic Article
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity Academic Article
Influenza virus-like particles engineered by protein transfer with tumor-associated antigens induces protective antitumor immunity Academic Article
Infrared fluorescence for vascular barrier breach in vivo - a novel method for quantitation of albumin efflux Academic Article
Inhibiting oxidative phosphorylation in vivo restrains Th17 effector responses and ameliorates murine colitis Academic Article
Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay Academic Article
Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4 Academic Article
Inhibition of inflammation with celastrol fails to improve muscle function in dysferlin-deficient A/J mice Academic Article
Inhibition of mutation and combating the evolution of antibiotic resistance Academic Article
Inhibition of the IKK/NF-kappa B pathway by AAV gene transfer improves muscle regeneration in older mdx mice Academic Article
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects Academic Article
Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease Academic Article
Inhibitory effects of berberine against morphine-induced locomotor sensitization and analgesic tolerance in mice Academic Article
Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance Academic Article
Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes Academic Article
Interferon-γ production by peripheral lymphocytes predicts survival of tumor-bearing mice receiving dual PD-1/CTLA-4 blockade Academic Article
Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma Academic Article
Interleukin-1β contributes to the generation of experimental febrile seizures Academic Article
Interleukin-6 promotes systemic lupus erythematosus progression with Treg suppression approach in a murine systemic lupus erythematosus model Academic Article
Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons Academic Article
Interruption of vascular thrombosis by bolus anti-platelet glycoprotein IIb/IIIa monoclonal antibodies in baboons Academic Article
Intersecting pathways to neurodegeneration in parkinson's disease: Effects of the pesticide rotenone on dj-1, alpha-synuclein, and the ubiquitin-proteasome system Academic Article
Interstitial nephritis in rats immunized with heterologous tubular basement-membrane Academic Article
Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis Academic Article
Intracerebroventricular injection of amyloid-β peptides in normal mice to acutely induce alzheimer-like cognitive deficits Academic Article
Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke Academic Article
Intrathecal recombinant human 4-sulfatase reduces accumulation of glycosaminoglycans in dura of mucopolysaccharidosis VI cats Academic Article
Intratumoral cancer cell intravasation can occur independent of invasion into the adjacent stroma Academic Article
Investigating the role of DNA damage in tobacco smoking-induced spine degeneration Academic Article
Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus Academic Article
Is tissue plasminogen activator a threat to neurons? Academic Article
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model Academic Article
Issls prize winner: Inhibition of nf-kappa b activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging Academic Article
Jinx, an mcmv susceptibility phenotype caused by disruption of unc13d: A mouse model of type 3 familial hemophagocytic lymphohistiocytosis Academic Article
KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy Academic Article
Kappa opioid control of seizures produced by a virus in an animal model Academic Article
Kidney preservation by bone marrow cell transplantation in hereditary nephropathy Academic Article
Kidney repair and stem cells: A complex and controversial process Academic Article
Kinase mutations in human disease: Interpreting genotype-phenotype relationships Academic Article
Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis Academic Article
LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage Academic Article
LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation Academic Article
LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth Academic Article
Lack of prion infectivity in fixed heart tissue from patients with Creutzfeldt-Jakob disease or amyloid heart disease Academic Article
Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease Academic Article
Lacrimal gland inflammation deregulates extracellular matrix remodeling and alters molecular signature of epithelial stem/progenitor cells Academic Article
Lactational and postnatal exposure to polychlorinated biphenyls induces sex-specific anxiolytic behavior and cognitive deficit in mice offspring Academic Article
Late administration of monoclonal-antibody to leukocyte function-antigen 1 abrogates incipient murine cerebral malaria Academic Article
Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice Academic Article
Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (sigma r1) Academic Article
Lead optimization of antimalarial propafenone analogues Academic Article
Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin alpha v beta 5: implications for angiogenesis in human obesity Academic Article
Leptin promotes vascular remodeling and neointimal growth in mice Academic Article
Lessons from the cat: Feline immunodeficiency virus as a tool to develop intervention strategies against human immunodeficiency virus type 1 Academic Article
Lethal alpha-thalassemia created by gene targeting in mice and its genetic rescue Academic Article
Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM) Academic Article
Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver Academic Article
Lipid presentation by the protein C receptor links coagulation with autoimmunity Academic Article
Lipopolysaccharide induction of tissue factor expression in rabbits Academic Article
Lipoproteins accumulate in immune deposits and are modified by lipid peroxidation in passive heymann nephritis Academic Article
Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile x syndrome Academic Article
Localization of cholesterol, amyloid and glia in alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (tof-sims) and immunofluorescence imaging Academic Article
Long-term evaluation of Leber's hereditary optic neuropathy-like symptoms in rotenone administered rats Academic Article
Longitudinal analysis of behavioral, neurophysiological, viral and immunological effects of SIV infection in rhesus monkeys Academic Article
Lop12, a mutation in mouse Crygd causing lens opacity similar to human Coppock cataract Academic Article
Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation Academic Article
Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies Academic Article
Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats Academic Article
Low-affinity cytotoxic t-lymphocytes require ifn-gamma to clear an acute viral infection Academic Article
Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma Academic Article
Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity Academic Article
Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice Academic Article
Lysophosphatidic acid signaling may initiate fetal hydrocephalus Academic Article
Lysophosphatidic acid stimulates the intestinal brush border NA(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF Academic Article
MOR209/ES414, a novel bispecific antibody targeting PSMA for the treatment of metastatic castration-resistant prostate cancer Academic Article
Machine learning models and pathway genome data base for trypanosoma cruzi drug discovery Academic Article
Macro view of microrna function in osteoarthritis Academic Article
Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy Academic Article
Manipulation of Panx1 activity increases the engraftment of transplanted lacrimal gland epithelial progenitor cells Academic Article
Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: An immediate source for thousands of new mouse models Academic Article
Measles virus infection in a transgenic model: Virus-induced immunosuppression and central nervous system disease Academic Article
Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats Academic Article
Mechanism of toxicity in rotenone models of parkinson's disease Academic Article
Mechanisms of acute kidney injury induced by experimental Lonomia obliqua envenomation Academic Article
Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis Academic Article
Mechanisms underlying hypoxia tolerance in drosophila melanogaster: Hairy as a metabolic switch Academic Article
Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs Academic Article
Melanocortin pathway: Animal models of obesity and disease Academic Article
Melanopsin contributions to irradiance coding in the thalamo-cortical visual system Academic Article
Merlin in organ size control and tumorigenesis: Hippo versus EGFR? Academic Article
Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia Academic Article
Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease Academic Article
MiR-980 is a memory suppressor microRNA that regulates the autism-susceptibility gene A2bp1 Academic Article
Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia Academic Article
MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer Academic Article
Microorganisms and autoimmunity: Making the barren field fertile? Academic Article
Microrna-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function Academic Article
Mimicry of high-density lipoprotein: functional peptide-lipid nanoparticles based on multivalent peptide constructs Academic Article
Modeling AIDS in a mouse Academic Article
Modeling a task that is sensitive to dementia of the Alzheimer's type: individual differences in acquisition of a visuo-spatial paired-associate learning task in rhesus monkeys Academic Article
Modeling human methamphetamine exposure in nonhuman primates: chronic dosing in the rhesus macaque leads to behavioral and physiological abnormalities Academic Article
Modeling relapse in animals Academic Article
Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control Academic Article
Modulation of disease-activity in murine systemic lupus-erythematosus by cytokine gene delivery Academic Article
Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis Academic Article
Molecular analysis of the murine lupus-associated anti-self response - involvement of a large number of heavy and light chain variable region genes Academic Article
Molecular and cell biology of the prototypic arenavirus LCMV: Implications for understanding and combating hemorrhagic fever arenaviruses Academic Article
Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry Academic Article
Molecular and chemical genetic approaches to developmental origins of aging and disease in zebrafish Academic Article
Molecular cloning and functional characterization of zebrafish ATM Academic Article
Molecular genetics of murine lupus models Academic Article
Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition Academic Article
Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties Academic Article
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Molecular pathway to protection from age-dependent photoreceptor degeneration in Mef2 deficiency Academic Article
Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice Academic Article
Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling Academic Article
Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of Down syndrome Academic Article
Monoclonal anti-histone autoantibodies derived from murine models of lupus Academic Article
Monoclonal autoantibodies to nuclear antigens from murine graft-versus-host disease Academic Article
Monoclonal igm rheumatoid factors derived from arthritic mrl mp-lpr lpr mice Academic Article
Monocyte chemoattractant protein-1 expression correlates with monocyte infiltration in the post-ischemic kidney Academic Article
Motoneuron development influences dorsal root ganglia survival and Schwann cell development in a vertebrate model of spinal muscular atrophy Academic Article
Mouse genetics at work: a new model of chronic hepadnavirus infection - Comments Academic Article
Mouse liver repopulation with hepatocytes generated from human fibroblasts Academic Article
Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes Academic Article
Mouse model of subretinal neovascularization with choroidal anastomosis Academic Article
Mouse models for dengue vaccines and antivirals Academic Article
Mouse models for generating p53 gene mutation spectra Academic Article
Mouse models for melanoma: A personal perspective Academic Article
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Mouse models of hepatitis B virus pathogenesis Academic Article
Mouse models of human neurodegenerative disorders - requirements for medication development Academic Article
Multifunctional in vivo imaging of pancreatic islets during diabetes development Academic Article
Multiple oncogenes and tumor suppressor genes are structurally and functionally intact during hepatocarcinogenesis in hepatitis B virus transgenic mice Academic Article
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Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease Academic Article
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Mutation of the gastric hydrogen-potassium atpase alpha subunit causes iron-deficiency anemia in mice Academic Article
Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma Academic Article
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Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy Academic Article
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Nanostructure-initiator mass spectrometry (NIMS) imaging of brain cholesterol metabolites in Smith-Lemli-Opitz syndrome Academic Article
Natural history of Francisella tularensis in aerosol-challenged BALB/c Mice Academic Article
Nelumbinis semen reverses a decrease in hippocampal 5-ht release induced by chronic mild stress in rats Academic Article
Neointimal formation after endovascular arterial injury is markedly attenuated in db/db mice Academic Article
Neointimal hyperplasia after arterial injury is increased in a rat model of non-insulin-dependent diabetes mellitus Academic Article
Nephritogenic antibody mechanisms involving antigens within the glomerulus Academic Article
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Neuropeptide changes in a primate model (cebus-apella) for tardive-dyskinesia Academic Article
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Neuroprotective effect of long-term ndi1 gene expression in a chronic mouse model of parkinson disorder Academic Article
Neuroprotective effects of eucommia ulmoides oliv. Bark on amyloid beta(25-35)-induced learning and memory impairments in mice Academic Article
Neuroscience of addiction Academic Article
Neurotoxic effects of feline immunodeficiency virus, FIV-PPR Academic Article
Neutralization takes precedence over IgG or IgA isotype-related functions in mucosal HIV-1 antibody-mediated protection Academic Article
Neutralizing Polyclonal IgG Present during Acute Infection Prevents Rapid Disease Onset in Simian-Human Immunodeficiency Virus SHIVSF162P3-Infected Infant Rhesus Macaques Academic Article
Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo Academic Article
Neutrophil activation by the tissue factor/factor viia/par2 axis mediates fetal death in a mouse model of anti phospholipid syndrome Academic Article
New dimensions in human laboratory models of addiction Academic Article
New model systems for hepatitis B virus research Academic Article
New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales Academic Article
New therapeutic targets revealed through investigations of innate immunity Academic Article
Nicotine vapor inhalation escalates nicotine self-administration Academic Article
Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation Academic Article
Non-invasive multimodality imaging directly shows TRPM4 inhibition ameliorates stroke reperfusion injury Academic Article
Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome Academic Article
Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer's disease Academic Article
Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein a-i Academic Article
Nonhuman primate models and the failure of the merck hiv-1 vaccine in humans Academic Article
Notch signaling in pancreatic cancer: oncogene or tumor suppressor? Academic Article
Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects Academic Article
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Novel origin of lpr and gld cells and possible implications in autoimmunity Academic Article
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Novel strategy for inhibiting viral entry by use of a cellular receptor-plant virus chimera Academic Article
Novel tricyclic antagonists of the prostaglandin D-2 receptor DP2 with efficacy in a murine model of allergic rhinitis Academic Article
Nuclear covalently closed circular viral genomic DNA in the liver of hepatocyte nuclear factor 1 alpha-null hepatitis B virus transgenic mice Academic Article
Nucleotide excision repair deficient mouse models and neurological disease Academic Article
Obligatory role for complex i inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) Academic Article
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On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models Academic Article
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function Academic Article
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism Academic Article
One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the blt model for evaluation of new microbicide candidates Academic Article
Operant alcohol self-administration in dependent rats: focus on the vapor model Academic Article
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Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy Academic Article
Optic nerve axon number in mouse is regulated by PAX2 Academic Article
Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models Academic Article
Oral exposure to Listeria monocytogenes in aged IL-17RKO mice: A possible murine model to study listeriosis in susceptible populations Academic Article
Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor Academic Article
Osteoarthritis gene therapy Academic Article
Ovariectomy and genes encoding core circadian regulatory proteins in murine bone Academic Article
Overexpression of human apoai transgene provides long-term atheroprotection in ldl receptor-deficient mice Academic Article
PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis Academic Article
PAI-1, fibrosis, and the elusive provisional fibrin matrix Academic Article
Pan-ebolavirus and pan-filovirus mouse monoclonal antibodies: protection against Ebola and Sudan viruses Academic Article
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Participation of macrophages and monocytes in experimental immune-complex glomerulonephritis Academic Article
Participation of tumor necrosis factor in the mediation of gram-negative bacterial lipopolysaccharide-induced injury in rabbits Academic Article
Passive immunization with a human monoclonal antibody protects hu-pbl-scid mice against challenge by primary isolates of hiv-1 Academic Article
Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus Academic Article
Pathogenesis of cytomegalovirus-infection .1. Activation of virus from bone marrow-derived lymphocytes by in vitro allogenic reaction Academic Article
Pathogenesis of slow disease of central nervous-system associated with wm-1504-e virus Academic Article
Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses Academic Article
Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris Academic Article
Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice Academic Article
Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus Academic Article
Performing subretinal injections in rodents to deliver retinal pigment epithelium cells in suspension Academic Article
Peripheral reduction of beta-amyloid is sufficient to reduce brain beta-amyloid: Implications for alzheimer's disease Academic Article
Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence Academic Article
Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase Academic Article
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Pharmacokinetics and efficacy of the spleen tyrosine kinase inhibitor r406 after ocular delivery for retinoblastoma Academic Article
Pharmacological activation of the neurotensin receptor 1 abrogates the methamphetamine-induced striatal apoptosis in the mouse brain Academic Article
Pharmacological approaches for the prevention of restenosis after percutaneous coronary intervention Academic Article
Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation Academic Article
Pharmacological characterization of the late phase reduction in lung functions and correlations with microvascular leakage and lung edema in allergen-challenged Brown Norway rats Academic Article
Pharmacological evaluation of selective α2c-adrenergic agonists in experimental animal models of nasal congestion Academic Article
Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials Academic Article
Pharmacological selectivity within class I histone deacetylases predicts effects on synaptic function and memory rescue Academic Article
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Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism Academic Article
Phenotypic characterization of a genetically diverse panel of mice for behavioral despair and anxiety Academic Article
Phosphoinositide 3-kinase regulates glycolysis through mobilization of aldolase from the actin cytoskeleton Academic Article
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class i histone deacetylases Academic Article
Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses Academic Article
Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease Academic Article
Platelet glycoprotein Ib alpha supports experimental lung metastasis Academic Article
Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia Academic Article
Platelets mediate cytotoxic T lymphocyte-induced liver damage Academic Article
Plazomicin is effective in a non-human primate pneumonic plague model Academic Article
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Postcocaine anhedonia: an animal model of cocaine withdrawal Academic Article
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Potential of the scid mouse as a host for human tumors Academic Article
PrP(TSE) distribution in a primate model of variant, sporadic, and iatrogenic Creutzfeldt-Jakob disease Academic Article
Pre- and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody Academic Article
Preclinical metabolic changes in mouse prion diseases detected by 1H-nuclear magnetic resonance spectroscopy Academic Article
Preclinical studies for pharmacokinetics and biodistribution of AD-stTRAIL, an adenovirus delivering secretable trimeric trail for gene therapy Academic Article
Preclinical trials using an immunoconjugate of t101 and methotrexate in an athymic mouse human t-cell tumor-model Academic Article
Preclinical validation of a novel cocaine exposure therapy for relapse prevention Academic Article
Preliminary PET study of F-18-FC119S in normal and Alzheimer's disease models Academic Article
Premature aging-related peripheral neuropathy in a mouse model of progeria Academic Article
Prenatal and postnatal exposure to bisphenol a induces anxiolytic behaviors and cognitive deficits in mice Academic Article
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Prion-induced amyloid heart disease with high blood infectivity in transgenic mice Academic Article
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Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model Academic Article
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Proteases and oxidants in experimental pulmonary inflammatory injury Academic Article
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness Academic Article
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Protection against colitis by CD100-dependent modulation of intraepithelial gamma delta T lymphocyte function Academic Article
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Protection of nude mice by passive immunization with a type-common human recombinant monoclonal antibody against hsv Academic Article
Protection of the intestinal mucosa by intraepithelial gamma delta T cells Academic Article
Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1 Academic Article
Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 Mice Academic Article
Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration Academic Article
Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis Academic Article
Protein transduction: Identification, characterization and optimization Academic Article
Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis Academic Article
Pyelonephritic escherichia coli expressing p fimbriae decrease immune response of the mouse kidney Academic Article
Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists Academic Article
Quantitative evaluation of local drug delivery using the infusasleeve catheter Academic Article
Quantitative in vivo and ex vivo confocal microscopy analysis of corneal cystine crystals in the Ctns(-/-) knockout mouse Academic Article
Quantitative polymerase chain-reaction analysis reveals marked overexpression of interleukin-1-beta, interleukin-10 and interferon-gamma messenger-RNA in the lymph-nodes of lupus-prone mice Academic Article
R7BP modulates opiate analgesia and tolerance but not withdrawal Academic Article
RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy Academic Article
Rapid differential endogenous plasminogen activator expression after acute middle cerebral artery occlusion Academic Article
Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting Academic Article
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins Academic Article
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Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model Academic Article
Recombinant soluble p-selectin glycoprotein ligand-ig (rpsgl-ig) attenuates infarct size and myeloperoxidase activity in a canine model of ischemia-reperfusion Academic Article
Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of schizophrenia Academic Article
Reduction in myocardial infarct size by basic fibroblast growth factor following coronary occlusion in a canine model Academic Article
Reduction of anxiety after restricted feeding in the rat: Implication for eating disorders Academic Article
Reduction of rat myocardial ischemia and reperfusion injury by sialyl lewis x oligosaccharide and anti-rat p-selectin antibodies Academic Article
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Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc Academic Article
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists Academic Article
Regulation of immunity by lysosphingolipids and their g protein - coupled receptors Academic Article
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Regulation of macrophage migration by a novel plasminogen receptor Plg-R(KT) Academic Article
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Renal response to blood pressure elevation in normal and glomerulonephritic rats Academic Article
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Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells Academic Article
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Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors Academic Article
Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging Academic Article
Reversal of disease-related pathologies in the fragile x mouse model by selective activation of gaba(b) receptors with arbaclofen Academic Article
Reversal of obesity and insulin resistance by a non-peptidic glucagon-like peptide-1 receptor agonist in diet-induced obese mice Academic Article
Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway Academic Article
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S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis Academic Article
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Sphingosine-1-phosphate receptor agonism reduces Bordetella pertussis-mediated lung pathology Academic Article
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Stemming vision loss with stem cells Academic Article
Stimulus conditioned to foot-shock stress reinstates alcohol-seeking behavior in an animal model of relapse Academic Article
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The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme Academic Article
The opioid peptides enkephalin and beta-endorphin in alcohol dependence Academic Article
The origin and function of soluble cd14 in experimental bacterial meningitis Academic Article
The response to burn injury in mice with human hematolymphoid systems Academic Article
The restenosis paradigm revisited - an alternative proposal for cellular mechanisms Academic Article
The role of complement in experimental disease models Academic Article
The role of craving in alcohol use, dependence, and treatment Academic Article
The role of nitric oxide in articular cartilage damage Academic Article
The role of platelet adhesion receptor GPIb alpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis Academic Article
The selective monoacylglycerol lipase inhibitor MJN110 produces opioid-sparing effects in a mouse neuropathic pain model Academic Article
The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 attenuates a scopolamine-induced deficit in a novel rodent attention task Academic Article
The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking Academic Article
The skinny on brain-derived neurotrophic factor: evidence from animal models to GWAS Academic Article
The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism Academic Article
The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice Academic Article
The temporal expression patterns of fibronectin and its receptors-α5β1 and αvβ3 integrins on blood vessels after cerebral ischemia Academic Article
The toll of toll-like receptors, especially toll-like receptor 2, on murine atherosclerosis Academic Article
The transition from controlled to compulsive drug use is associated with a loss of sensitization Academic Article
Theoretical frameworks and mechanistic aspects of alcohol addiction: Alcohol addiction as a reward deficit disorder Academic Article
Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models Academic Article
Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment Academic Article
Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models Academic Article
Therapeutic potential of new antiinflammatory drugs Academic Article
Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease Academic Article
Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption Academic Article
Tissue factor contributes to microvascular defects after focal cerebral ischemia Academic Article
Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model - studies in tPA-deficient mice and wild-type mice on a matched genetic background Academic Article
Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice Academic Article
Tissue-specific regulation of p38α-mediated inflammation in Con A-induced acute liver damage Academic Article
Tlr2 in murine atherosclerosis Academic Article
Tlr4/md-2 monoclonal antibody therapy affords protection in experimental models of septic shock Academic Article
Tlrs and ifns: Critical pieces of the autoimmunity puzzle Academic Article
Tolerance induction by the blockade of CD40/CD154 interaction in pemphigus vulgaris mouse model Academic Article
Tolerance to alcohol: A critical yet understudied factor in alcohol addiction Academic Article
Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection Academic Article
Toll-like receptors and atherosclerosis - key contributors in disease and health? Academic Article
Toll-like receptors in atherosclerosis Academic Article
Toward an aids vaccine Academic Article
Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease Academic Article
Transdifferentiation of glioblastoma cells into vascular endothelial cells Academic Article
Transfer of a functional human immune system to mice with severe combined immunodeficiency Academic Article
Transfer of human chronic lymphocytic leukemia to mice with severe combined immune deficiency Academic Article
Transfer of pro alpha 2(i) cdna into cells of a murine model of human osteogenesis imperfecta restores synthesis of type i collagen comprised of alpha 1(i) and alpha 2(i) heterotrimers in vitro and in vivo Academic Article
Transgenic mice expressing human hla and cd8 molecules generate hla-restricted measles virus cytotoxic t lymphocytes of the same specificity as humans with natural measles virus infection Academic Article
Transmission of prions Academic Article
Transplantation of virally transduced cells into the dermis of immunocompetent and immunodeficient (SCID) mice to determine gene expression profile and differential donor cell survival Academic Article
Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease? Academic Article
Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of a beta toxicity Academic Article
Transthyretin: The servant of many masters Academic Article
Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity Academic Article
Treatment of mice with human monoclonal antibody 24 h after lethal aerosol challenge with virulent Venezuelan equine encephalitis virus prevents disease but not infection Academic Article
Treatment with lxr agonists after focal cerebral ischemia prevents brain damage Academic Article
Tubulointerstitial nephritis induced in the brown norway rat with chaotropically solubilized bovine tubular basement-membrane - the model and the humoral and cellular-responses Academic Article
Tumor necrosis factor in mediating experimental hemophilus-influenzae type-b meningitis Academic Article
Tumor-targeted il-2 amplifies t cell-mediated immune response induced by gene therapy with single-chain il-12 Academic Article
Two msbb genes encoding maximal acylation of lipid a are required for invasive shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium Academic Article
Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model Academic Article
Type I and type II interferon coordinately regulate suppressive dendritic cell fate and function during viral persistence Academic Article
Type i interferon during viral infections: Multiple triggers for a multifunctional mediator Academic Article
Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris Academic Article
Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model Academic Article
Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations Academic Article
Unravelling the association of partial T-cell immunodeficiency and immune dysregulation Academic Article
Upregulation of fibronectin and the α5β1 and αvβ3 integrins on blood vessels within the cerebral ischemic penumbra Academic Article
Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior Academic Article
Use of a novel mouse genotype to model acute benzodiazepine withdrawal Academic Article
Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model Academic Article
Using transgenic mouse models to dissect the pathogenesis of virus-induced autoimmune disorders of the islets of langerhans and the central nervous system Academic Article
Utility of genetically modified mice for understanding the neurobiology of substance use disorders Academic Article
VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice Academic Article
VBP15, a novel dissociative steroid compound, reduces NFκB-induced expression of inflammatory cytokines in vitro and symptoms of murine trinitrobenzene sulfonic acid-induced colitis Academic Article
Vaccination against tie2 reduces atherosclerosis Academic Article
Vascular remodeling underlies rebleeding in hemophilic arthropathy Academic Article
Viral persistence: Parameters, mechanisms and future predictions Academic Article
Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis Academic Article
Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and multiple sclerosis Academic Article
Virus-induced diabetes in a transgenic model: Role of cross-reacting viruses and quantitation of effector t cells needed to cause disease Academic Article
Volumetric evaluation of the ischemic lesion size with serial mri in a transient mcao model of the rat: Comparison of dwi and t1wi Academic Article
Whither or wither microbicides? Academic Article
Whole animal section insitu hybridization and protein blotting - new tools in molecular analysis of animal-models for human-disease Academic Article
Why are some amyloidoses systemic? Does hepatic "chaperoning at a distance" prevent cardiac deposition in a transgenic model of human senile systemic (transthyretin) amyloidosis? Academic Article
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C Academic Article
Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone BXSB mice Academic Article
Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice Academic Article
[HIV glycoprotein 120: possible etiological agent of AIDS-associated dementia] [Article in Spanish] Academic Article
betaCaMKII in lateral habenula mediates core symptoms of depression Academic Article
gp120 and neurotoxicity in vivo Academic Article
hu-PBL-SCID mice: a model for human immune function, AIDS, and lymphomagenesis Academic Article
von Willebrand's disease Academic Article

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