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Diabetes Mellitus, Type 1

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  • A novel method for generating region-specific monoclonal-antibodies to modified proteins - application to the identification of human glucosylated low-density lipoproteins  Academic Article
  • A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas  Academic Article
  • A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice  Academic Article
  • A structural framework for deciphering the link between I-A(g7) and autoimmune diabetes  Academic Article
  • A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes  Academic Article
  • AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice  Academic Article
  • Abrogation of diabetes in bb rats by acute virus-infection - association of viral-lymphocyte interactions  Academic Article
  • Adenovirus e3 mhc inhibitory genes but not tnf/fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes  Academic Article
  • Among cxcr3 chemokines, ifn-gamma-inducible protein of 10 kda (cxc chemokine ligand (cxcl) 10) but not monokine induced by ifn-gamma (cxcl9) imprints a pattern for the subsequent development of autoimmune disease  Academic Article
  • Analysis of pancreas-infiltrating t-cells in diabetic nod mice - fusion with bw5147 yields a high-frequency of islet-reactive hybridomas  Academic Article
  • Antigen processing by autoreactive B cells promotes determinant spreading  Academic Article
  • Autoimmune diabetes can be induced in transgenic major histocompatibility complex class-ii-deficient mice  Academic Article
  • B cell selection defects underlie the development of diabetogenic apcs in nonobese diabetic mice  Academic Article
  • B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets  Academic Article
  • Bead injection ELISA for the determination of antibodies implicated in type 1 diabetes mellitus  Academic Article
  • CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles  Academic Article
  • Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5  Academic Article
  • Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice  Academic Article
  • Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms  Academic Article
  • Coexpression of b7-1 and viral (''self'') transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes  Academic Article
  • Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus  Academic Article
  • Constitutive beta cell expression of il-12 does not perturb self-tolerance but intensifies established autoimmune diabetes  Academic Article
  • Crosses of nod mice with the related non strain - a polygenic model for iddm  Academic Article
  • Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient  Academic Article
  • Cytotoxic lymphocytes-t do not control lymphocytic choriomeningitis virus-infection of bb diabetes-prone rats  Academic Article
  • DNA immunization to prevent autoimmune diabetes  Academic Article
  • DNA vaccination to treat autoimmune diabetes  Academic Article
  • Decreased plasma levels of protein S in well-controlled type I diabetes mellitus  Academic Article
  • Defective CD8+ T cell peripheral tolerance in nonobese diabetic mice  Academic Article
  • Defects in deletional tolerance of CD8+ T cells in autoimmune diabetes  Academic Article
  • Discovery of native autoantigens via antigen surrogate technology: Application to type 1 diabetes  Academic Article
  • DsAAV8-mediated gene transfer and beta-cell expression of IL-4 and beta-cell growth factors are capable of reversing early-onset diabetes in NOD mice  Academic Article
  • Efficient gene delivery to human and rodent islets with double-stranded (ds) aav-based vectors  Academic Article
  • Expression of adenoviral e3 transgenes in beta cells prevents autoimmune diabetes  Academic Article
  • Failure to detect genomic viral sequences in pancreatic tissues from 2 children with acute-onset diabetes-mellitus  Academic Article
  • Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity  Academic Article
  • First chronic platelet glycoprotein iib/iiia integrin blockade - a randomized, placebo-controlled pilot study of xemilofiban in unstable angina with percutaneous coronary interventions  Academic Article
  • Focal expression of interleukin-2 does not break unresponsiveness to self (viral) antigen expressed in beta-cells but enhances development of autoimmune-disease (diabetes) after initiation of an anti-self immune-response  Academic Article
  • Gene and cell therapies for diabetes mellitus - strategies and clinical potential  Academic Article
  • Gene combination transfer to block autoimmune damage in transplanted islets of Langerhans  Academic Article
  • Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes  Academic Article
  • Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes  Academic Article
  • High affinity binding of conformationally constrained synthetic oligomers to an antigen-specific antibody: Discovery of a diagnostically useful synthetic ligand for murine Type 1 diabetes autoantibodies  Academic Article
  • High frequency of TNF alleles -238A and -376A in individuals from northern Sardinia  Academic Article
  • How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model  Academic Article
  • IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice  Academic Article
  • Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells  Academic Article
  • Immunology of type 1 diabetes - intervention and prevention strategies  Academic Article
  • Immunotherapeutic gene transfer into muscle  Academic Article
  • In a transgenic model of spontaneous autoimmune diabetes, expression of a protective class II MHC molecule results in thymic deletion of diabetogenic CD8+ T cells  Academic Article
  • In vivo treatment with a mhc class i-restricted blocking peptide can prevent virus-induced autoimmune diabetes  Academic Article
  • Indoleamine 2,3-dioxygenase expression in trans-planted NOD islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes  Academic Article
  • Influence of diabetes mellitus on clinical outcomes across the spectrum of acute coronary syndromes - findings from the gusto-iib study  Academic Article
  • Inhibition of diabetes in bb rats by virus-infection  Academic Article
  • Inhibition of diabetes in bb rats by virus-infection .2. Effect of virus-infection on the immune-response to nonviral and viral-antigens  Academic Article
  • Insulin in oral immune "tolerance": A one-amino acid change in the b chain makes the difference  Academic Article
  • Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice  Academic Article
  • Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus  Academic Article
  • Islet-specific expression of cxcl10 causes spontaneous islet infiltration and accelerates diabetes development  Academic Article
  • Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes  Academic Article
  • Lipid autoreactivity in multiple sclerosis  Academic Article
  • Lymphoid hyperplasia, CD45RBhigh to CD45RBlow T-cell imbalance, and suppression of Type I diabetes mellitus result from TNF blockade in NOD --> NOD-scid adoptive T cell transfer  Academic Article
  • Lysophosphatidylserine regulates blood glucose by enhancing glucose transport in myotubes and adipocytes  Academic Article
  • Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions  Academic Article
  • Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice  Academic Article
  • Modulation of early inflammatory reactions to promote engraftment and function of transplanted pancreatic islets in autoimmune diabetes  Academic Article
  • Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes  Academic Article
  • Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry  Academic Article
  • Molecular mimicry and immune-mediated diseases  Academic Article
  • Neither b lymphocytes nor antibodies directed against self antigens of the islets of langerhans are required for development of virus-induced autoimmune diabetes  Academic Article
  • Neointimal formation after endovascular arterial injury is markedly attenuated in db/db mice  Academic Article
  • Ontogeny of T cell tolerance to peripherally expressed antigens  Academic Article
  • Oral insulin (human, murine, or porcine) does not prevent diabetes in the non-obese diabetic mouse  Academic Article
  • Pancreatic panniculitis associated with allograft pancreatitis and rejection in a simultaneous pancreas-kidney transplant recipient  Academic Article
  • Pancreatic-islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction  Academic Article
  • Pathogenesis and treatment of virus-induced autoimmune diabetes: novel insights gained from the RIP-LCMV transgenic mouse model  Academic Article
  • Pathway analysis of seven common diseases assessed by genome-wide association  Academic Article
  • Plasma apolipoproteins-ai, apolipoprotein-aii, apolipoprotein-b, apolipoprotein-ci, and apolipoprotein-e are glucosylated in hyperglycemic diabetic subjects  Academic Article
  • Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor i  Academic Article
  • Prevention of diabetes in NOD nice by administration of dendritic cells deficient in nuclear transcription factor-kappa B activity  Academic Article
  • Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression  Academic Article
  • Prevention of type-i diabetes in nonobese diabetic mice by virus-infection  Academic Article
  • Programmed death-1 ligands-transfected dendritic cells loaded with glutamic acid decarboxylase 65 (GAD65) inhibit both the alloresponse and the GAD65-reactive lymphocyte response  Academic Article
  • Ptpn22 and Cd2 variations are associated with altered protein expression and susceptibility to type 1 diabetes in nonobese diabetic mice  Academic Article
  • ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes  Academic Article
  • Reliable diagnosis of murine type 1 diabetes using a panel of autoantigens and "antigen surrogates'' mounted onto a liquid array  Academic Article
  • Renal allograft and patient outcome after transplantation: Pancreas-kidney versus kidney-alone transplants in type 1 diabetic patients versus kidney-alone transplants in nondiabetic patients  Academic Article
  • Role of CCL2/MCP-1 in islet transplantation  Academic Article
  • Role of viruses in the loss of tolerance to self-antigens and in autoimmune-diseases  Academic Article
  • Role of viruses in type i diabetes  Academic Article
  • Selection of aberrant class II restricted CD8(+) T cells in NOD mice expressing a glutamic acid decarboxylase (GAD) 65-specific T cell receptor transgene  Academic Article
  • Self-tolerance and the composition of T cell repertoire  Academic Article
  • Sensitization to self (virus) antigen by in-situ expression of murine interferon-gamma  Academic Article
  • Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens  Academic Article
  • Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule  Academic Article
  • Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases  Academic Article
  • Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity  Academic Article
  • T cell populations in the pancreatic lymph node naturally and consistently expand and contract in NOD mice as disease progresses  Academic Article
  • Targeting autoimmune diabetes with gene therapy  Academic Article
  • Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice  Academic Article
  • Testing the NKT cell hypothesis of human IDDM pathogenesis  Academic Article
  • The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder  Academic Article
  • The basis of autoimmunity .2. Genetic predisposition  Academic Article
  • The role of Fas-FasL in CD8+ T-cell-mediated insulin-dependent diabetes mellitus (IDDM)  Academic Article
  • The use of Idd congenic mice to identify checkpoints of peripheral tolerance to islet antigen  Academic Article
  • Tracing the action of IL-2 in tolerance to islet-specific antigen  Academic Article
  • Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages  Academic Article
  • Transforming growth factor-beta fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice  Academic Article
  • Type I interferons (α/β) in immunity and autoimmunity  Academic Article
  • Using transgenic mouse models to dissect the pathogenesis of virus-induced autoimmune disorders of the islets of langerhans and the central nervous system  Academic Article
  • Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and multiple sclerosis  Academic Article
  • Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and other autoimmune diseases  Academic Article
  • Virus-induced diabetes in a transgenic model: Role of cross-reacting viruses and quantitation of effector t cells needed to cause disease  Academic Article
  • Virus-infection triggers insulin-dependent diabetes-mellitus in a transgenic model - role of anti-self (virus) immune-response  Academic Article
  • Viruses as therapeutic agents .1. Treatment of nonobese insulin-dependent diabetes mice with virus prevents insulin-dependent diabetes-mellitus while maintaining general immune competence  Academic Article
  • Viruses as therapeutic agents .2. Viral reassortants map prevention of insulin-dependent diabetes-mellitus to the small rna of lymphocytic choriomeningitis virus  Academic Article

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