subject area of
- A novel method for generating region-specific monoclonal-antibodies to modified proteins - application to the identification of human glucosylated low-density lipoproteins Academic Article
- A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas Academic Article
- A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice Academic Article
- A structural framework for deciphering the link between I-A(g7) and autoimmune diabetes Academic Article
- A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes Academic Article
- AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice Academic Article
- Abrogation of diabetes in bb rats by acute virus-infection - association of viral-lymphocyte interactions Academic Article
- Adenovirus e3 mhc inhibitory genes but not tnf/fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes Academic Article
- Among cxcr3 chemokines, ifn-gamma-inducible protein of 10 kda (cxc chemokine ligand (cxcl) 10) but not monokine induced by ifn-gamma (cxcl9) imprints a pattern for the subsequent development of autoimmune disease Academic Article
- Analysis of pancreas-infiltrating t-cells in diabetic nod mice - fusion with bw5147 yields a high-frequency of islet-reactive hybridomas Academic Article
- Antigen processing by autoreactive B cells promotes determinant spreading Academic Article
- Autoimmune diabetes can be induced in transgenic major histocompatibility complex class-ii-deficient mice Academic Article
- B cell selection defects underlie the development of diabetogenic apcs in nonobese diabetic mice Academic Article
- B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets Academic Article
- Bead injection ELISA for the determination of antibodies implicated in type 1 diabetes mellitus Academic Article
- CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles Academic Article
- Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5 Academic Article
- Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice Academic Article
- Coexpression of b7-1 and viral (''self'') transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes Academic Article
- Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus Academic Article
- Constitutive beta cell expression of il-12 does not perturb self-tolerance but intensifies established autoimmune diabetes Academic Article
- Crosses of nod mice with the related non strain - a polygenic model for iddm Academic Article
- Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient Academic Article
- Cytotoxic lymphocytes-t do not control lymphocytic choriomeningitis virus-infection of bb diabetes-prone rats Academic Article
- DNA immunization to prevent autoimmune diabetes Academic Article
- DNA vaccination to treat autoimmune diabetes Academic Article
- Decreased plasma levels of protein S in well-controlled type I diabetes mellitus Academic Article
- Defective CD8+ T cell peripheral tolerance in nonobese diabetic mice Academic Article
- Defects in deletional tolerance of CD8+ T cells in autoimmune diabetes Academic Article
- Discovery of native autoantigens via antigen surrogate technology: Application to type 1 diabetes Academic Article
- DsAAV8-mediated gene transfer and beta-cell expression of IL-4 and beta-cell growth factors are capable of reversing early-onset diabetes in NOD mice Academic Article
- Efficient gene delivery to human and rodent islets with double-stranded (ds) aav-based vectors Academic Article
- Expression of adenoviral e3 transgenes in beta cells prevents autoimmune diabetes Academic Article
- Failure to detect genomic viral sequences in pancreatic tissues from 2 children with acute-onset diabetes-mellitus Academic Article
- Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity Academic Article
- First chronic platelet glycoprotein iib/iiia integrin blockade - a randomized, placebo-controlled pilot study of xemilofiban in unstable angina with percutaneous coronary interventions Academic Article
- Focal expression of interleukin-2 does not break unresponsiveness to self (viral) antigen expressed in beta-cells but enhances development of autoimmune-disease (diabetes) after initiation of an anti-self immune-response Academic Article
- Gene and cell therapies for diabetes mellitus - strategies and clinical potential Academic Article
- Gene combination transfer to block autoimmune damage in transplanted islets of Langerhans Academic Article
- Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes Academic Article
- Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes Academic Article
- High affinity binding of conformationally constrained synthetic oligomers to an antigen-specific antibody: Discovery of a diagnostically useful synthetic ligand for murine Type 1 diabetes autoantibodies Academic Article
- High frequency of TNF alleles -238A and -376A in individuals from northern Sardinia Academic Article
- How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model Academic Article
- IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice Academic Article
- Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells Academic Article
- Immunology of type 1 diabetes - intervention and prevention strategies Academic Article
- Immunotherapeutic gene transfer into muscle Academic Article
- In a transgenic model of spontaneous autoimmune diabetes, expression of a protective class II MHC molecule results in thymic deletion of diabetogenic CD8+ T cells Academic Article
- In vivo treatment with a mhc class i-restricted blocking peptide can prevent virus-induced autoimmune diabetes Academic Article
- Indoleamine 2,3-dioxygenase expression in trans-planted NOD islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes Academic Article
- Influence of diabetes mellitus on clinical outcomes across the spectrum of acute coronary syndromes - findings from the gusto-iib study Academic Article
- Inhibition of diabetes in bb rats by virus-infection Academic Article
- Inhibition of diabetes in bb rats by virus-infection .2. Effect of virus-infection on the immune-response to nonviral and viral-antigens Academic Article
- Insulin in oral immune "tolerance": A one-amino acid change in the b chain makes the difference Academic Article
- Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice Academic Article
- Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus Academic Article
- Islet-specific expression of cxcl10 causes spontaneous islet infiltration and accelerates diabetes development Academic Article
- Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes Academic Article
- Lipid autoreactivity in multiple sclerosis Academic Article
- Lymphoid hyperplasia, CD45RBhigh to CD45RBlow T-cell imbalance, and suppression of Type I diabetes mellitus result from TNF blockade in NOD --> NOD-scid adoptive T cell transfer Academic Article
- Lysophosphatidylserine regulates blood glucose by enhancing glucose transport in myotubes and adipocytes Academic Article
- Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions Academic Article
- Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice Academic Article
- Modulation of early inflammatory reactions to promote engraftment and function of transplanted pancreatic islets in autoimmune diabetes Academic Article
- Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes Academic Article
- Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry Academic Article
- Molecular mimicry and immune-mediated diseases Academic Article
- Neither b lymphocytes nor antibodies directed against self antigens of the islets of langerhans are required for development of virus-induced autoimmune diabetes Academic Article
- Neointimal formation after endovascular arterial injury is markedly attenuated in db/db mice Academic Article
- Ontogeny of T cell tolerance to peripherally expressed antigens Academic Article
- Oral insulin (human, murine, or porcine) does not prevent diabetes in the non-obese diabetic mouse Academic Article
- Pancreatic panniculitis associated with allograft pancreatitis and rejection in a simultaneous pancreas-kidney transplant recipient Academic Article
- Pancreatic-islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction Academic Article
- Pathogenesis and treatment of virus-induced autoimmune diabetes: novel insights gained from the RIP-LCMV transgenic mouse model Academic Article
- Pathway analysis of seven common diseases assessed by genome-wide association Academic Article
- Plasma apolipoproteins-ai, apolipoprotein-aii, apolipoprotein-b, apolipoprotein-ci, and apolipoprotein-e are glucosylated in hyperglycemic diabetic subjects Academic Article
- Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor i Academic Article
- Prevention of diabetes in NOD nice by administration of dendritic cells deficient in nuclear transcription factor-kappa B activity Academic Article
- Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression Academic Article
- Prevention of type-i diabetes in nonobese diabetic mice by virus-infection Academic Article
- Programmed death-1 ligands-transfected dendritic cells loaded with glutamic acid decarboxylase 65 (GAD65) inhibit both the alloresponse and the GAD65-reactive lymphocyte response Academic Article
- Ptpn22 and Cd2 variations are associated with altered protein expression and susceptibility to type 1 diabetes in nonobese diabetic mice Academic Article
- ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes Academic Article
- Reliable diagnosis of murine type 1 diabetes using a panel of autoantigens and "antigen surrogates'' mounted onto a liquid array Academic Article
- Renal allograft and patient outcome after transplantation: Pancreas-kidney versus kidney-alone transplants in type 1 diabetic patients versus kidney-alone transplants in nondiabetic patients Academic Article
- Role of CCL2/MCP-1 in islet transplantation Academic Article
- Role of viruses in the loss of tolerance to self-antigens and in autoimmune-diseases Academic Article
- Role of viruses in type i diabetes Academic Article
- Selection of aberrant class II restricted CD8(+) T cells in NOD mice expressing a glutamic acid decarboxylase (GAD) 65-specific T cell receptor transgene Academic Article
- Self-tolerance and the composition of T cell repertoire Academic Article
- Sensitization to self (virus) antigen by in-situ expression of murine interferon-gamma Academic Article
- Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens Academic Article
- Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule Academic Article
- Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases Academic Article
- Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity Academic Article
- T cell populations in the pancreatic lymph node naturally and consistently expand and contract in NOD mice as disease progresses Academic Article
- Targeting autoimmune diabetes with gene therapy Academic Article
- Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice Academic Article
- Testing the NKT cell hypothesis of human IDDM pathogenesis Academic Article
- The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder Academic Article
- The basis of autoimmunity .2. Genetic predisposition Academic Article
- The role of Fas-FasL in CD8+ T-cell-mediated insulin-dependent diabetes mellitus (IDDM) Academic Article
- The use of Idd congenic mice to identify checkpoints of peripheral tolerance to islet antigen Academic Article
- Tracing the action of IL-2 in tolerance to islet-specific antigen Academic Article
- Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages Academic Article
- Transforming growth factor-beta fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice Academic Article
- Type I interferons (α/β) in immunity and autoimmunity Academic Article
- Using transgenic mouse models to dissect the pathogenesis of virus-induced autoimmune disorders of the islets of langerhans and the central nervous system Academic Article
- Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and multiple sclerosis Academic Article
- Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and other autoimmune diseases Academic Article
- Virus-induced diabetes in a transgenic model: Role of cross-reacting viruses and quantitation of effector t cells needed to cause disease Academic Article
- Virus-infection triggers insulin-dependent diabetes-mellitus in a transgenic model - role of anti-self (virus) immune-response Academic Article
- Viruses as therapeutic agents .1. Treatment of nonobese insulin-dependent diabetes mice with virus prevents insulin-dependent diabetes-mellitus while maintaining general immune competence Academic Article
- Viruses as therapeutic agents .2. Viral reassortants map prevention of insulin-dependent diabetes-mellitus to the small rna of lymphocytic choriomeningitis virus Academic Article