subject area of

• 1-beta-D-arabinofuranosylcytosine inhibits Borna disease virus replication and spread  Academic Article
• A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication  Academic Article
• A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPAR gamma partial agonists  Academic Article
• A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol  Academic Article
• A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases  Academic Article
• A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis  Academic Article
• A human microprotein that interacts with the mRNA decapping complex  Academic Article
• A novel cross-talk in diacylglycerol signaling the rac-gap beta 2-chimaerin is negatively regulated by protein kinase c delta-mediated phosphorylation  Academic Article
• A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects  Academic Article
• A second fatty acid amide hydrolase with variable distribution among placental mammals  Academic Article
• A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection  Academic Article
• A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome  Academic Article
• A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junin hemorrhagic fever arenavirus  Academic Article
• A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat-containing RNA  Academic Article
• A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates  Academic Article
• Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne 3+2 cycloaddition  Academic Article
• Adenovirus chromatin structure at different stages of infection  Academic Article
• Adenovirus core protein pvii is translocated into the nucleus by multiple import receptor pathways  Academic Article
• Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction  Academic Article
• An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation  Academic Article
• Analysis of HSV viral reactivation in explants of sensory neurons  Academic Article
• Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera  Academic Article
• Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus  Academic Article
• Animal models for retrovirus-induced immunodeficiency disease  Academic Article
• Antibody-sensitive and antibody-resistant cell-to-cell spread by vaccinia virus: role of the A33R protein in anti body-resistant spread  Academic Article
• Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation  Academic Article
• Antigen compartmentation and t helper cell tolerance induction  Academic Article
• Antisense masking reveals contributions of mrna- rrna base pairing to translation of gtx and fgf2 mrnas  Academic Article
• Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models  Academic Article
• Arenavirus nucleoproteins prevent activation of nuclear factor kappa b  Academic Article
• Arenavirus reverse genetics for vaccine development  Academic Article
• Attenuated measles virus as a vaccine vector  Academic Article
• Barx2 and Pax7 have antagonistic functions in regulation of wnt signaling and satellite cell differentiation  Academic Article
• Benzouracil-coumarin-arene conjugates as inhibiting agents for chikungunya virus  Academic Article
• Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase  Academic Article
• Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo  Academic Article
• Borna disease virus requires cholesterol in both cellular membrane and viral envelope for efficient cell entry  Academic Article
• Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis  Academic Article
• Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1  Academic Article
• Cell entry of Borna disease virus follows a clathrin-mediated endocytosis pathway that requires Rab5 and microtubules  Academic Article
• Cell-to-cell spread of Borna disease virus proceeds in the absence of the virus primary receptor and furin-mediated processing of the virus surface glycoprotein  Academic Article
• Cells expressing the RING finger Z protein are resistant to arenavirus infection  Academic Article
• Cellular uptake and fate of PEGylated gold nanoparticles is dependent on both cell-penetration peptides and particle size  Academic Article
• Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential  Academic Article
• Characterization of the structure and function of a novel map kinase kinase (mkk6)  Academic Article
• Cholesteryl ester hydrolase activity is abolished in HSL(-/-) macrophages but unchanged in macrophages lacking KIAA1363  Academic Article
• Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling  Academic Article
• Clinical isolates of measles virus use cd46 as a cellular receptor?  Academic Article
• Clinical significance of st3gal iv expression in human renal cell carcinoma  Academic Article
• Co-opting the Fanconi anemia genomic stability pathway enables herpesvirus DNA synthesis and productive growth  Academic Article
• Coactivators PGC-1 beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen  Academic Article
• Combining metabolite-based pharmacophores with Bayesian machine learning models for mycobacterium tuberculosis drug discovery  Academic Article
• Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor  Academic Article
• Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody  Academic Article
• Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity  Academic Article
• Delivering quantum dot-peptide bioconjugates to the cellular cytosol: escaping from the endolysosomal system  Academic Article
• Detection and typing of herpes simplex viruses by using recombinant immunoglobulin fragments produced in bacteria  Academic Article
• Determinants of initiation codon selection during translation in mammalian cells  Academic Article
• Development of live-attenuated arenavirus vaccines based on codon deoptimization  Academic Article
• Different mechanisms of cell entry by human-pathogenic old world and new world arenaviruses  Academic Article
• Differential activation of CREB by Ca(2+)/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity  Academic Article
• Differential inhibition of type I interferon induction by arenavirus nucleoproteins  Academic Article
• Directed selection of recombinant human monoclonal-antibodies to herpes-simplex virus glycoproteins from phage display libraries  Academic Article
• Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS  Academic Article
• Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics  Academic Article
• Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus  Academic Article
• Dynamics of the hypoxia-inducible factor-1-vascular endothelial growth factor promoter complex  Academic Article
• Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking  Academic Article
• Early virus-host interactions dictate the course of a persistent infection  Academic Article
• Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling  Academic Article
• Ebola virus can be effectively neutralized by antibody produced in natural human infection  Academic Article
• Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (peta-3/cd151) as an effector of human tumor cell migration and metastasis  Academic Article
• Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide  Academic Article
• Evaluation of diverse peptidyl motifs for cellular delivery of semiconductor quantum dots  Academic Article
• Evidence that the hypermutated m protein of a subacute sclerosing panencephalitis measles virus actively contributes to the chronic progressive cns disease  Academic Article
• Exposure of plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity  Academic Article
• Expression and characterization of von Willebrand factor dimerization defects in different types of von Willebrand disease  Academic Article
• FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles  Academic Article
• Follistatin-like protein-1 is a novel proinflammatory molecule  Academic Article
• Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase  Academic Article
• Functional characterization of the genomic promoter of Borna disease virus (BDV): Implications of 3 '-terminal sequence heterogeneity for BDV persistence  Academic Article
• General molecular strategy for development of arenavirus live-attenuated vaccines  Academic Article
• Generation and characterization of a recombinant vesicular stomatitis virus expressing the glycoprotein of Borna disease virus  Academic Article
• Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest  Academic Article
• Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles  Academic Article
• Genetic analysis of the SARS-coronavirus spike glycoprotein functional domains involved in cell-surface expression and cell-to-cell fusion  Academic Article
• Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity  Academic Article
• Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development  Academic Article
• Golgicide A reveals essential roles for GBF1 in Golgi assembly and function  Academic Article
• HSV neutralization by the microbicidal candidate C5A  Academic Article
• IFITM3 polymorphism rs12252-C restricts influenza A viruses  Academic Article
• Identification and characterization of a new intron in Borna disease virus  Academic Article
• Identification and expression of neu4, a novel murine sialidase  Academic Article
• Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors  Academic Article
• Identification and mechanism of action of a novel small-molecule inhibitor of arenavirus multiplication  Academic Article
• Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse  Academic Article
• Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides  Academic Article
• Il-18 translational inhibition restricts ifn-gamma expression in crescentic glomerulonephritis  Academic Article
• Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins  Academic Article
• Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4  Academic Article
• Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway  Academic Article
• Inhibition of multiplication of the prototypic arenavirus LCMV by valproic acid  Academic Article
• Inhibition of non-ATG translational events in cells via covalent small molecules targeting RNA  Academic Article
• Inhibition of the severe acute respiratory syndrome 3cl protease by peptidomimetic alpha,beta-unsaturated esters  Academic Article
• Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus  Academic Article
• Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers  Academic Article
• Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo  Academic Article
• Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis  Academic Article
• Interleukin-1-alpha stimulates kc synthesis in rat mesangial cells - glucocorticoids inhibit kc induction by il-1  Academic Article
• Intracellular antibody against Clostridium-perfringens entero-toxin fails to counteract toxin-induced damage  Academic Article
• Involvement of the v1/v2 variable loop structure in the exposure of human-immunodeficiency-virus type-1 gp120 epitopes induced by receptor-binding  Academic Article
• Isolation of Borna disease virus from human brain tissue  Academic Article
• Laminin-alpha 4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells  Academic Article
• Local clustering of transferrin receptors promotes clathrin-coated pit initiation  Academic Article
• Low-affinity cytotoxic t-lymphocytes require ifn-gamma to clear an acute viral infection  Academic Article
• Lung Kruppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase  Academic Article
• Male germ cells support long-term propagation of Zika virus  Academic Article
• Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck  Academic Article
• Mapping a common interaction site used by plasmodium falciparum duffy binding-like domains to bind diverse host receptors  Academic Article
• Mapping enzyme active sites in complex proteomes  Academic Article
• Measles virus recognizes its receptor, cd46, via two distinct binding domains within scr1-2  Academic Article
• Mechanisms for lymphocytic choriomeningitis virus glycoprotein cleavage, transport, and incorporation into virions  Academic Article
• Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides  Academic Article
• Mice Lacking Functional STAT1 Are Highly Susceptible to Lethal Infection with Lassa Virus  Academic Article
• Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition  Academic Article
• Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family  Academic Article
• Monoclonal-antibody analysis of purified and cell-associated tissue factor  Academic Article
• Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin  Academic Article
• Mouse RC/BTB2, a member of the RCC1 superfamily, localizes to spermatid acrosomal vesicles  Academic Article
• Multifunctional compact zwitterionic ligands for preparing robust biocompatible semiconductor quantum dots and gold nanoparticles  Academic Article
• Mutagenesis-mediated virus extinction: Virus-dependent effect of viral load on sensitivity to lethal defection  Academic Article
• Mutations in the env gene of human immunodeficiency virus type 1 NDK isolates and the use of African green monkey CXCR4 as a co-receptor in COS-7 cells  Academic Article
• N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels  Academic Article
• Novel isoforms of the TFIID subunit TAF4 modulate nuclear receptor-mediated transcriptional activity  Academic Article
• O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors  Academic Article
• Old world arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell  Academic Article
• Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase  Academic Article
• Oxadiazoles have butyrate-specific conditional activity against mycobacterium tuberculosis  Academic Article
• Palmitoylation of the cysteine-rich endodomain of the SARS-coronavirus spike glycoprotein is important for spike-mediated cell fusion  Academic Article
• Partial agonists activate PPAR gamma using a helix 12 independent mechanism  Academic Article
• Peptidomics of prolyl endopeptidase in the central nervous system  Academic Article
• Plazomicin is effective in a non-human primate pneumonic plague model  Academic Article
• Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase  Academic Article
• Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine  Academic Article
• Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy  Academic Article
• Protection of nude mice by passive immunization with a type-common human recombinant monoclonal antibody against hsv  Academic Article
• Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3  Academic Article
• Protocadherin-19 is essential for early steps in brain morphogenesis  Academic Article
• Quantum-dot/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensing  Academic Article
• RIG-I enhanced interferon independent apoptosis upon Junin virus infection  Academic Article
• Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry  Academic Article
• Recombinant human fab to glycoprotein-d neutralizes infectivity and prevents cell-to-cell transmission of herpes-simplex virus-1 and virus-2 in-vitro  Academic Article
• Recombinant human monoclonal antibodies to ebola virus  Academic Article
• Recombinant lymphocytic choriomeningitis virus expressing vesicular stomatitis virus glycoprotein  Academic Article
• Recombinant measles viruses expressing heterologous antigens of mumps and simian immunodeficiency viruses  Academic Article
• Redox-based probes as tools to monitor oxidized protein tyrosine phosphatases in living cells  Academic Article
• Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: Evidence for a link between defects in the endocannabinoid system and problem drug use  Academic Article
• Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor  Academic Article
• Rescue from cloned cDNAs and in vivo characterization of recombinant pathogenic Romero and live-attenuated Candid #1 strains of Junin virus, the causative agent of Argentine hemorrhagic fever disease  Academic Article
• Rho-family gtpases regulate p38 mitogen-activated protein-kinase through the downstream mediator pak1  Academic Article
• SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells  Academic Article
• SCFCdc4 acts antagonistically to the PGC-1 alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis  Academic Article
• Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery  Academic Article
• Site-directed elisa identifies a highly antigenic region of the simian immunodeficiency virus transmembrane glycoprotein  Academic Article
• Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neurons  Academic Article
• Small molecules targeting severe acute respiratory syndrome human coronavirus  Academic Article
• Small-molecule inhibitors of the c-Fes protein-tyrosine kinase  Academic Article
• Sperm associated antigen 6 (SPAG6) regulates fibroblast cell growth, morphology, migration and ciliogenesis  Academic Article
• Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence  Academic Article
• Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway  Academic Article
• Structure and function correlation in histone H2A peptide-mediated gene transfer  Academic Article
• Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids  Academic Article
• Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus  Academic Article
• Synthesis and characterization of BODIPY-labeled colchicine  Academic Article
• T-705 (favipiravir) inhibition of arenavirus replication in cell culture  Academic Article
• Tab-1 modulates intracellular localization of p38 map kinase and downstream signaling  Academic Article
• Tak1, but not tab1 or tab2, plays an essential role in multiple signaling pathways in vivo  Academic Article
• Takusan: A large gene family that regulates synaptic activity  Academic Article
• Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides  Academic Article
• The N-terminal nuclear localization sequences of liver X receptors α and β bind to importin α and are essential for both nuclear import and transactivating functions  Academic Article
• The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein  Academic Article
• The PI3K/Akt pathway contributes to arenavirus budding  Academic Article
• The ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway  Academic Article
• The f-bar domains from srgap1, srgap2 and srgap3 regulate membrane deformation differently  Academic Article
• The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors  Academic Article
• The small RING finger protein Z drives arenavirus budding: Implications for antiviral strategies  Academic Article
• Trans-inactivation of receptor tyrosine kinases by novel angiotensin ii at2 receptor-interacting protein, atip  Academic Article
• UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs  Academic Article
• Ultra-potent antibodies against respiratory syncytial virus: effects of binding kinetics and binding valence on viral neutralization  Academic Article
• Ultrastructure of SARS-CoV, FIPV, and MHV revealed by electron cryomicroscopy  Academic Article
• Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses  Academic Article
• Use of a nonviral vector to express a chimeric trna-ribozyme against lymphocytic choriomeningitis virus: Cytoplasmic accumulation of a catalytically competent transcript but minimal antiviral effect  Academic Article
• Use of single-cycle infectious lymphocytic choriomeningitis virus to study hemorrhagic fever arenaviruses  Academic Article
• V and c proteins of measles virus function as virulence factors in vivo  Academic Article
• VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses  Academic Article
• Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain  Academic Article
• Virus-induced diabetes in a transgenic model: Role of cross-reacting viruses and quantitation of effector t cells needed to cause disease  Academic Article
• [Ca2+]i elevation and oxidative stress induce KCNQ1 protein translocation from the cytosol to the cell surface and increase slow delayed rectifier (IKs) in cardiac myocytes  Academic Article
• cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1  Academic Article