subject area of
- A stem cell-based approach to cartilage repair Academic Article
- Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining Academic Article
- Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws Academic Article
- Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle Academic Article
- Aging-related differences in chondrocyte viscoelastic properties Academic Article
- Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis Academic Article
- An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints Academic Article
- Apoptosis in rheumatic disease Academic Article
- Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes Academic Article
- Autophagy activation by rapamycin reduces severity of experimental osteoarthritis Academic Article
- Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA Academic Article
- Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis Academic Article
- Basic science of intra-articular fractures and posttraumatic osteoarthritis Academic Article
- Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes Academic Article
- Biomechanical, structural, and biochemical indices of degenerative and osteoarthritic deterioration of adult human articular cartilage of the femoral condyle Academic Article
- Biomechanics of cartilage articulation Academic Article
- C/EBP homologous protein drives pro-catabolic responses in chondrocytes Academic Article
- Cartilage and joint inflammation - regulation of IL-8 expression by human articular chondrocytes Academic Article
- Cartilage cell clusters Academic Article
- Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis Academic Article
- Cell death in cartilage Academic Article
- Cell density modulates apoptosis in human articular chondrocytes Academic Article
- Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis Academic Article
- Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro Academic Article
- Chemotaxis of human articular chondrocytes and mesenchymal stem cells Academic Article
- Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1 beta and tumor necrosis factor alpha Academic Article
- Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis Academic Article
- Chondrocyte apoptosis and regional differential expression of nitric oxide in the medial meniscus following partial meniscectomy Academic Article
- Chondrocyte calcium-sensing receptor expression is up-regulated in early guinea pig knee osteoarthritis and modulates PTHrP, MMP-13, and TIMP-3 expression Academic Article
- Chondrocyte clusters adjacent to sites of cartilage degeneration have characteristics of progenitor cells Academic Article
- Chondrocyte-derived apoptotic bodies and calcification of articular cartilage Academic Article
- Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway Academic Article
- Comparative biomechanical analysis of human and caprine knee articular cartilage Academic Article
- Comparison of cartilage histopathology assessment systems on human knee joints at all stages of osteoarthritis development Academic Article
- Computational wear simulation of patellofemoral articular cartilage during in vitro testing Academic Article
- Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis Academic Article
- Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis Academic Article
- Correlation between anatomic features and low-field magnetic resonance imaging of the equine metacarpophalangeal joint Academic Article
- Cross-reactive epitope with klebsiella-pneumoniae nitrogenase in articular tissue of hla-b27+ patients with ankylosing-spondylitis Academic Article
- Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes Academic Article
- Cytokine regulation of facilitated glucose transport in human articular chondrocytes Academic Article
- Development and regulation of osteophyte formation during experimental osteoarthritis Academic Article
- Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis Academic Article
- Development of gene-based therapies for cartilage repair Academic Article
- Differential expression of tgf-beta isoforms by human articular chondrocytes in response to growth-factors Academic Article
- Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes Academic Article
- Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes Academic Article
- Differentiation-dependent and stimulus-specific expression of ILA, the human 4-1BB-homologue, in cells of mesenchymal origin Academic Article
- Differentiation-dependent effects of IL-1 and TGF-beta on human articular chondrocyte proliferation are related to inducible nitric-oxide synthase expression Academic Article
- Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees Academic Article
- Direct adenovirus-mediated IGF-l gene transduction of synovium induces persisting synovial fluid IGF-l ligand elevations Academic Article
- Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects Academic Article
- Direct adenovirus-mediated insulin-like growth factor i gene transfer enhances transplant chondrocyte function Academic Article
- Direct human cartilage repair using three-dimensional bioprinting technology Academic Article
- Distinct pathways regulate facilitated glucose transport in human articular chondrocytes during anabolic and catabolic responses Academic Article
- Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis Academic Article
- Effect of osteochondral graft insertion forces on chondrocyte viability Academic Article
- Effects of aging on articular cartilage homeostasis Academic Article
- Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogels Academic Article
- Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: A feasibility study Academic Article
- Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes Academic Article
- Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage Academic Article
- Expression of microRNA-146a in osteoarthritis cartilage Academic Article
- Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage Academic Article
- Expression of prepro-enkephalin in human articular chondrocytes is linked to cell-proliferation Academic Article
- Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation Academic Article
- Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways Academic Article
- Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis Academic Article
- Fibroblast growth factor 4 directs gap junction expression in the mesenchyme of the vertebrate limb Bud Academic Article
- FoxO transcription factors support oxidative stress resistance in human chondrocytes Academic Article
- Gene therapy of arthritis Academic Article
- Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation Academic Article
- Genetic enhancement of matrix synthesis by articular chondrocytes - comparison of different growth factor genes in the presence and absence of interleukin-1 Academic Article
- Glucosamine activates autophagy in vitro and in vivo Academic Article
- Growth and differentiation of prechondrogenic cells on bioactive self-assembled peptide nanofibers Academic Article
- Growth-factor responsiveness of human articular chondrocytes - distinct profiles in primary chondrocytes, subcultured chondrocytes, and fibroblasts Academic Article
- Growth-factor responsiveness of human articular chondrocytes in aging and development Academic Article
- HIV-1 transactivator protein Tat induces proliferation and TGF-beta expression in human articular chondrocytes Academic Article
- Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone Academic Article
- Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis Academic Article
- Histopathological changes in the human posterior cruciate ligament during aging and osteoarthritis: Correlations with anterior cruciate ligament and cartilage changes Academic Article
- Human IL-1ra gene transfer into human synovial fibroblasts is chondroprotective Academic Article
- Human articular chondrocytes exhibit sexual dimorphism in their responses to 17 beta-estradiol Academic Article
- Human chondrocyte apoptosis in response to mechanical injury Academic Article
- Human, viral or mutant human il-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis Academic Article
- Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration Academic Article
- Hyaluronic acid and chondroitin sulfate content of osteoarthritic human knee cartilage: Site-specific correlation with weight-bearing force based on femorotibial angle measurement Academic Article
- IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses Academic Article
- IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects Academic Article
- IL-6 production by human articular chondrocytes - modulation of its synthesis by cytokines, growth-factors, and hormones in vitro Academic Article
- IL-8/CXCL8 and growth-related oncogene α/CXCL1 induce chondrocyte hypertrophic differentiation Academic Article
- Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage Academic Article
- Il-1-beta and il-6 selectively induce transforming growth-factor-beta isoforms in human articular chondrocytes Academic Article
- Implantable sensor technology: from research to clinical practice Academic Article
- In situ tissue engineering using magnetically guided three-dimensional cell patterning Academic Article
- In vitro model of full-thickness cartilage defect healing Academic Article
- In vivo changes after mechanical injury Academic Article
- Increased intracellular ca2+ selectively suppresses il-1-induced no production by reducing inos messenger-rna stability Academic Article
- Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta(1) gene into articular chondrocytes Academic Article
- Induction of cytokine expression by leukemia inhibitory factor Academic Article
- Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products Academic Article
- Inflammatory events in cartilage in early stages of femoroacetabular impingement: Commentary on an article by Shingo Hashimoto, MD, PhD, et al.: "Molecular characterization of articular cartilage from young adults with femoroacetabular impingement" Academic Article
- Influence of cartilage extracellular matrix molecules on cell phenotype and neocartilage formation Academic Article
- Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway Academic Article
- Inhibition of the development of collagen-induced arthritis in rhesus monkeys by a small molecular weight antagonist of CCR5 Academic Article
- Inorganic pyrophosphate (PPI) in pathologic calcification of articular cartilage Academic Article
- Insulinlike growth factor-l gene therapy applications for cartilage repair Academic Article
- Integrin expression by human articular chondrocytes Academic Article
- Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa Academic Article
- Interleukin-1-beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes Academic Article
- Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases Academic Article
- Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappa B Academic Article
- Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA) Academic Article
- Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus Academic Article
- Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis Academic Article
- Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes Academic Article
- Macro view of microrna function in osteoarthritis Academic Article
- Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection Academic Article
- Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis Academic Article
- Mesenchymal progenitor cells in adult human articular cartilage Academic Article
- MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes Academic Article
- MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses Academic Article
- Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α. Academic Article
- Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization Academic Article
- Molecular network of cartilage homeostasis and osteoarthritis Academic Article
- Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid Academic Article
- N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes Academic Article
- One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist Academic Article
- Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1 Academic Article
- Pannocytes: Distinctive cells found in rheumatoid arthritis articular cartilage erosions Academic Article
- Parathyroid hormone-related protein is abundant in osteoarthritic cartilage, and the parathyroid hormone-related protein 1-173 isoform is selectively induced by transforming growth factor beta in articular chondrocytes and suppresses generation of extracellular inorganic pyrophosphate Academic Article
- Potential treatment of osteoarthritis by gene therapy Academic Article
- Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation Academic Article
- Profile of glycosaminoglycan-degrading glycosidases and glycoside sulfatases secreted by human articular chondrocytes in homeostasis and inflammation Academic Article
- Regulation of CD95 (Fas/APO-1)-induced apoptosis in human chondrocytes Academic Article
- Regulation of YKL-40 production by human articular chondrocytes Academic Article
- Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes Academic Article
- Repair of cartilage defects in arthritic tissue with differentiated human embryonic stem cells Academic Article
- Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice Academic Article
- Subchondral bone of the human knee in aging and osteoarthritis Academic Article
- TSG-6 expression in human articular chondrocytes - possible implications in joint inflammation and cartilage degradation Academic Article
- The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigen Academic Article
- The effect of glycosaminoglycan loss on chondrocyte viability: a study on porcine cartilage explants Academic Article
- The osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear factor kappa B ligand system in cartilage Academic Article
- The pathology of the end-stage osteoarthritic lesion of the knee: potential role in cartilage repair Academic Article
- The relationship of autophagy defects to cartilage damage during joint aging in a mouse model Academic Article
- The role of IFN regulatory factor-1 in synovitis and nitric oxide production Academic Article
- The role of nitric oxide in articular cartilage damage Academic Article
- The tetrabasic KKKK147-150 motif determines intracrine regulatory effects of PTHrP 1-173 on chondrocyte PPi metabolism and matrix synthesis Academic Article
- Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage Academic Article
- Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA Academic Article
- Transthyretin deposition in articular cartilage: a novel mechanism in the pathogenesis of osteoarthritis Academic Article
- Tyrosine kinases are involved with the expression of inducible nitric-oxide synthase in human articular chondrocytes Academic Article
- Ultrashort echo time MR imaging of osteochondral junction of the knee at 3 T: identification of anatomic structures contributing to signal intensity Academic Article
- Ultrashort-echo time MR imaging of the patella with bicomponent analysis: correlation with histopathologic and polarized light microscopic findings Academic Article
- Up-regulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcification Academic Article
- Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular PPi excess Academic Article
- Use of an antibody against the matrix metalloproteinase-generated aggrecan neoepitope FVDIPEN-COOH to assess the effects of stromelysin in a rabbit model of cartilage degradation Academic Article
- Using gene therapy to protect and restore cartilage Academic Article
- Value of biomarkers in osteoarthritis: current status and perspectives Academic Article
- WISP3-dependent regulation aggrecan production of type II collagen and in chondrocytes Academic Article
- Zone-specific gene expression patterns in articular cartilage Academic Article
- microRNAs and cartilage Academic Article