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Biotransformation

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  • Activation and transfer of novel synthetic 9-substituted sialic acids  Academic Article
  • Activation of methotrexate-alpha-alanine by carboxypeptidase-A monoclonal-antibody conjugate  Academic Article
  • Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans  Academic Article
  • Bioactivation of the epidermal growth factor receptor inhibitor gefitinib: Implications for pulmonary and hepatic toxicities  Academic Article
  • Biotransformation of nociceptin orphanin fq by enzyme activity from morphine-naive and morphine-treated cell cultures  Academic Article
  • Carboxylesterase isoenzyme specific deacylation of diacetoxyscirpenol (anguidine)  Academic Article
  • Catalysis of divergent pathways of 2-acetylaminofluorene metabolism by multiple forms of cytochrome P-450  Academic Article
  • Characterization of T-5 N-oxide formation as the first highly selective measure of CYP3A5 activity  Academic Article
  • Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment  Academic Article
  • Cytochrome P450-mediated bioactivation of the epidermal growth factor receptor inhibitor erlotinib to a reactive electrophile  Academic Article
  • Design and use of fluorogenic aldehydes for monitoring the progress of aldehyde transformations  Academic Article
  • Effect of microsomal cytochrome P-450 isozyme induction on the mutagenic activation of 2-aminoanthracene  Academic Article
  • Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry  Academic Article
  • In vivo activity in a catalytic antibody-prodrug system: antibody catalyzed etoposide prodrug activation for selective chemotherapy  Academic Article
  • L-arginine analogs as alternate substrates for nitric oxide synthase  Academic Article
  • Mammalian synthesis of nitrite, nitrate, nitric oxide, and n-nitrosating agents  Academic Article
  • Modification of biophysical and endotoxic properties of bacterial lipopolysaccharides by serum  Academic Article
  • Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy  Academic Article
  • Pharmacokinetics of orally administered camptothecins  Academic Article
  • Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug  Academic Article
  • Visualizing antibody-catalyzed retro-aldol-retro-michael reactions  Academic Article

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