subject area of

• 1.35 and 2.07 a resolution structures of the red abalone sperm lysin monomer and dimer reveal features involved in receptor binding  Academic Article
• 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase  Academic Article
• 2,5-diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3)  Academic Article
• 2-(3,5-dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor  Academic Article
• 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport  Academic Article
• 3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting  Academic Article
• 3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle  Academic Article
• 3D domain swapping modulates the stability of members of an icosahedral virus group  Academic Article
• 4-Aminoindazolyl-dihydrofuro 3,4-d pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase  Academic Article
• A Disorder-to-Order Transition Activates an ATP-Independent Membrane Protein Chaperone  Academic Article
• A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs  Academic Article
• A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model  Academic Article
• A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis  Academic Article
• A base triple in the tetrahymena group i core affects the reaction equilibrium via a threshold effect  Academic Article
• A binding site for homeodomain and pax proteins is necessary for l1 cell adhesion molecule gene expression by pax-6 and bone morphogenetic proteins  Academic Article
• A binding site for pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord  Academic Article
• A branching reaction mechanism of glutathione reductase  Academic Article
• A brassinosteroid transcriptional network revealed by genome-wide identification of BESI target genes in Arabidopsis thaliana  Academic Article
• A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding  Academic Article
• A cell cycle phosphoproteome of the yeast centrosome  Academic Article
• A chemical, genetic, and structural analysis of the nuclear bile acid receptor fxr  Academic Article
• A chemically functionalized magnetic nanoplatform for rapid and specific biomolecular recognition and separation  Academic Article
• A chromatin binding-site in the tail domain of nuclear lamins that interacts with core histones  Academic Article
• A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease  Academic Article
• A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPAR gamma partial agonists  Academic Article
• A complex assembly landscape for the 30S ribosomal subunit  Academic Article
• A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis  Academic Article
• A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles  Academic Article
• A conserved hiv gp120 glycoprotein structure involved in chemokine receptor binding  Academic Article
• A conserved motif in the itk ph-domain is required for phosphoinositide binding and tcr signaling but dispensable for adaptor protein interactions  Academic Article
• A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase  Academic Article
• A de novo designed peptide ligase: A mechanistic investigation  Academic Article
• A de novo protein binding pair by computational design and directed evolution  Academic Article
• A density functional evaluation of an Fe(III)-Fe(IV) model diiron cluster: comparisons with ribonucleotide reductase intermediate X  Academic Article
• A designed inhibitor of a CLC antiporter blocks function through a unique binding mode  Academic Article
• A designed synthetic analogue of 4-OT is specific for a non-natural substrate  Academic Article
• A detailed structural model of cytotactin - protein homologies, alternative rna splicing, and binding regions  Academic Article
• A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons  Academic Article
• A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120  Academic Article
• A dynamic search process underlies microRNA targeting  Academic Article
• A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol)  Academic Article
• A flexible interface between DNA ligase and pcna supports conformational switching and efficient ligation of DNA  Academic Article
• A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking  Academic Article
• A four-helical super-secondary structure  Academic Article
• A fragment of human TrpRS as a potent antagonist of ocular angiogenesis  Academic Article
• A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia-coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases  Academic Article
• A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock  Academic Article
• A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding  Academic Article
• A g-protein alpha-subunit from asexual candida-albicans functions in the mating signal transduction pathway of saccharomyces-cerevisiae and is regulated by the a1-alpha-2 repressor  Academic Article
• A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain  Academic Article
• A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells  Academic Article
• A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans  Academic Article
• A genetically encoded diazirine photocrosslinker in Escherichia coli  Academic Article
• A genetically encoded fluorescent amino acid  Academic Article
• A global benchmark study using affinity-based biosensors  Academic Article
• A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728  Academic Article
• A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B  Academic Article
• A hierarchy of RNA subdomains in assembly of the central domain of the 30 S ribosomal subunit  Academic Article
• A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs  Academic Article
• A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV  Academic Article
• A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein  Academic Article
• A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS  Academic Article
• A linear amino acid sequence involved in the interaction of t-PA with its endothelial cell receptor  Academic Article
• A method for defining binding sites involved in protein-protein interactions: analysis of the binding of plasminogen activator inhibitor 1 to the somatomedin domain of vitronectin  Academic Article
• A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase  Academic Article
• A molecular switch regulating transcriptional repression and activation of PPARγ  Academic Article
• A mutation in the human cyclin-dependent kinase interacting protein, ckshs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly  Academic Article
• A new decoration for nitric oxide synthase - a zn(cys)4 site  Academic Article
• A new mechanism of allostery in a G protein-coupled receptor dimer  Academic Article
• A new model for binding of kinesin 13 to curved microtubule protofilaments  Academic Article
• A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic c-1027 biosynthesis  Academic Article
• A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A  Academic Article
• A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase  Academic Article
• A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties  Academic Article
• A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma  Academic Article
• A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va  Academic Article
• A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1  Academic Article
• A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex  Academic Article
• A novel role of the budding yeast separin esp1 in anaphase spindle elongation: Evidence that proper spindle association of esp1 is regulated by pds1  Academic Article
• A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity  Academic Article
• A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site  Academic Article
• A permutational approach toward protein-DNA recognition  Academic Article
• A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis  Academic Article
• A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding  Academic Article
• A poly(A) binding protein functions in the chloroplast as a message-specific translation factor  Academic Article
• A positive feedback loop controls transcription of the spoof gene, a component of the sporulation phosphorelay in bacillus-subtilis  Academic Article
• A protein-S binding-site on C4b-binding protein involves beta-chain residues 31-45  Academic Article
• A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.Fem-3 mRNA complex  Academic Article
• A random walk in oncogene space: The quest for targets  Academic Article
• A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation  Academic Article
• A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin  Academic Article
• A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria  Academic Article
• A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: Crystal structure of spo0f from bacillus subtilis  Academic Article
• A retroviral-like metal binding motif in an aminoacyl-tRNA synthetase is important for tRNA recognition  Academic Article
• A reversible reaction inside a self-assembled capsule  Academic Article
• A ribozyme composed of only two different nucleotides  Academic Article
• A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus  Academic Article
• A role for ranbp1 in the release of crm1 from the nuclear pore complex in a terminal step of nuclear export  Academic Article
• A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280  Academic Article
• A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib  Academic Article
• A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis  Academic Article
• A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases  Academic Article
• A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta  Academic Article
• A semisynthetic glutathione peroxidase with high catalytic efficiency: Selenoglutathione transferase  Academic Article
• A shape-dependent hydrophobic effect for tetrazoles  Academic Article
• A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth  Academic Article
• A silencer element in the retinoblastoma tumor-suppressor gene  Academic Article
• A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity  Academic Article
• A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure  Academic Article
• A single gal4 dimer can maximally activate transcription under physiological conditions  Academic Article
• A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors  Academic Article
• A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases  Academic Article
• A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases  Academic Article
• A small molecule inhibitor selective for a variant atp-binding site of the chaperonin groel  Academic Article
• A source of response regulator autophosphatase activity: The critical role of a residue adjacent to the spo0f autophosphorylation active site  Academic Article
• A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor  Academic Article
• A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle  Academic Article
• A sphingosine 1-phosphate receptor 2 selective allosteric agonist  Academic Article
• A stapled p53 helix overcomes HDMX-mediated suppression of p53  Academic Article
• A steady-state kinetic model of butyrylcholinesterase from horse plasma  Academic Article
• A steady-state-kinetic random mechanism for glutathione S-transferase A from rat liver. A model involving kinetically significant enzyme-product complexes in the forward reaction  Academic Article
• A structural model for the high-valent intermediate Q of methane monooxygenase from broken-symmetry density functional and electrostatics calculations  Academic Article
• A structural model for the prostate disease marker, human prostate-specific antigen  Academic Article
• A structural perspective of the sequence variability within botulinum neurotoxin subtypes a1-a4  Academic Article
• A structure-activity study of nociceptin-(1-13)-peptide amide. Synthesis of analogues substituted in positions 0, 1, 3, 4 and 10  Academic Article
• A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase  Academic Article
• A synthetic receptor for phosphocholine esters  Academic Article
• A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease  Academic Article
• A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen  Academic Article
• A translation-like cycle is a quality control checkpoint for maturing 40s ribosome subunits  Academic Article
• A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5  Academic Article
• A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry  Academic Article
• A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin mac-1 (cd11b cd18)  Academic Article
• A universal entropy-driven mechanism for thioredoxin-target recognition  Academic Article
• A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities  Academic Article
• ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair  Academic Article
• ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization  Academic Article
• ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase  Academic Article
• Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: The 3 ' ends justify the means  Academic Article
• Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: Formation of a pterin radical is required for enzyme activity  Academic Article
• Ablating adenovirus type 5 fiber-car binding and hi loop insertion of the sigyplp peptide generate an endothelial cell-selective adenovirus  Academic Article
• Absence of G(i) proteins in the Sf9 insect cell. Characterization of the uncoupled recombinant N-formyl peptide receptor  Academic Article
• Acceptor helix interactions in a class II tRNA synthetase: photoaffinity cross-linking of an RNA miniduplex substrate  Academic Article
• Acceptor substrate-based selective inhibition of galactosyltransferases  Academic Article
• Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gpl120 is sterically restricted on primary human immunodeficiency virus type 1  Academic Article
• Accessibility of nuclear chromatin by DNA binding polyamides  Academic Article
• Acetylcholine recognition by a deep, biomimetic pocket  Academic Article
• Acidophilic adaptations in the structure of Acetobacter aceti N-5-carboxyaminoimidazole ribonucleotide mutase (PurE)  Academic Article
• Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements  Academic Article
• Activation of Hageman factor in solid and fluid phases. A critical role of kallikrein  Academic Article
• Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1  Academic Article
• Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete c-terminal domain  Academic Article
• Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the a subunits  Academic Article
• Activation of the redox-regulated chaperone hsp33 by domain unfolding  Academic Article
• Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation  Academic Article
• Active and alkylated human agt structures: A novel zinc site, inhibitor and extrahelical base binding  Academic Article
• Active and inhibited human catalase structures: Ligand and nadph binding and catalytic mechanism  Academic Article
• Active site binding modes of curcumin in HIV-1 protease and integrase  Academic Article
• Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense  Academic Article
• Active site modification of factor viia affects interactions of the protease domain with tissue factor  Academic Article
• Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein  Academic Article
• Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties  Academic Article
• Active site residues of cyclophilin A are crucial for its signaling activity via CD147  Academic Article
• Active site structure of Rieske-type proteins: electron nuclear double resonance studies of isotopically labeled phthalate dioxygenase from Pseudomonas cepacia and Rieske protein from Rhodobacter capsulatus and molecular modeling studies of a Rieske center  Academic Article
• Active site structure of class I ribonucleotide reductase intermediate X: a density functional theory analysis of structure, energetics, and spectroscopy  Academic Article
• Active site-directed inhibition of rabbit cytochrome P-450 1 by amino-substituted steroids  Academic Article
• Active thymus derived suppressor lymphocytes in human cord blood  Academic Article
• Active, interactive, and inactive steroid-receptor mutants  Academic Article
• Active-site and oligosaccharide recognition residues of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f  Academic Article
• Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3  Academic Article
• Activity-based protein profiling for the functional annotation of enzymes  Academic Article
• Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid)  Academic Article
• Adaptation of influenza viruses to human airway receptors  Academic Article
• Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2  Academic Article
• Adding L-3-(2-naphthyl)alanine to the genetic code of E. coli  Academic Article
• Addition of an alpha-hydroxy acid to the genetic code of bacteria  Academic Article
• Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope  Academic Article
• Adenosine: a partial agonist of the growth hormone secretagogue receptor  Academic Article
• Adhesive properties of the isolated amino-terminal domain of platelet glycoprotein Ib alpha in a flow field  Academic Article
• Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenge  Academic Article
• Advances in pain therapeutics  Academic Article
• Affinity labeling of creatine kinase by N-(2,3-epoxypropyl)-N-amidinoglycine  Academic Article
• Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling  Academic Article
• Agonist-bound structure of the human P2Y(12) receptor  Academic Article
• Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence  Academic Article
• Alanine scanning mutagenesis of an alpha beta T cell receptor: mapping the energy of antigen recognition  Academic Article
• Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA  Academic Article
• Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition  Academic Article
• Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase  Academic Article
• Aldehyde dehydrogenase inhibitors: A comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application  Academic Article
• Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors  Academic Article
• Allosteric inhibition of hypoxia inducible factor-2 with small molecules  Academic Article
• Allosteric inhibition via R-state destabilization in ATP sulfurylase from Penicillium chrysogenum  Academic Article
• Alternative outcomes in assembly of promoter complexes: The roles of TBP and a flexible linker in placing TFIIIB on tRNA genes  Academic Article
• Amino acid derived quinazolines as Rock/PKA inhibitors  Academic Article
• Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles  Academic Article
• Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib  Academic Article
• Amino acid substitution at the dimeric interface of human manganese superoxide dismutase  Academic Article
• Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase  Academic Article
• Aminoacylation of RNA minihelices: implications for tRNA synthetase structural design and evolution  Academic Article
• Aminoglycoside binding in the major groove of duplex rna: The thermodynamic and electrostatic forces that govern recognition  Academic Article
• Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase  Academic Article
• An AP-1 site is involved in the NGF induction of IL-1α in PC12 cells  Academic Article
• An Engineered Arginine Residue of Unusual pH-Sensitive Reactivity Facilitates Site-Selective Antibody Conjugation  Academic Article
• An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines  Academic Article
• An L-RNA aptamer that binds and inhibits RNase  Academic Article
• An NMR perspective on enzyme dynamics  Academic Article
• An RNA binding site in a tRNA synthetase with a reduced set of amino acids  Academic Article
• An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors  Academic Article
• An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide  Academic Article
• An acyloxymethyl ketone-based probe to monitor the activity of glutathionylspermidine amidase in Escherichia coli  Academic Article
• An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1  Academic Article
• An alternate binding site for PPARγ ligands  Academic Article
• An alternative processing of integrin αv subunit in tumor cells by membrane type-1 matrix metalloproteinase  Academic Article
• An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance  Academic Article
• An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode  Academic Article
• An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription  Academic Article
• An analysis of a class of DNA sequence reading molecules  Academic Article
• An aptamer that neutralizes r5 strains of hiv-1 binds to core residues of gp120 in the ccr5 binding site  Academic Article
• An aptamer that neutralizes r5 strains of human immunodeficiency virus type 1 blocks gp120-ccr5 interaction  Academic Article
• An engineered mutant of hiv-1 gp120 formulated with adjuvant quil a promotes elicitation of antibody responses overlapping the cd4-binding site  Academic Article
• An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured  Academic Article
• An essential histidine residue in the catalytic mechanism of mammalian glutathione reductase  Academic Article
• An essential role for the conserved Glu-133 in the anion interaction with superoxide-dismutase  Academic Article
• An evolutionary approach to the design of glutathione-linked enzymes  Academic Article
• An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity  Academic Article
• An improved zinc-finger nuclease architecture for highly specific genome editing  Academic Article
• An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation  Academic Article
• An inhibitor of sequence-specific proteolysis that targets the substrate rather than the enzyme  Academic Article
• An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity  Academic Article
• An intramolecular signaling element that modulates dynamin function in vitro and in vivo  Academic Article
• An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin 5  Academic Article
• An o-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses  Academic Article
• An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution  Academic Article
• An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7  Academic Article
• An operational RNA code for amino acids and variations in critical nucleotide sequences in evolution  Academic Article
• An oxetane-based polyketide surrogate To probe substrate binding in a polyketide synthase  Academic Article
• An unusual dimeric structure and assembly for tlr4 regulator rp105-md-1  Academic Article
• Analysis of bacteriophage N protein and peptide binding to boxB RNA using polyacrylamide gel coelectrophoresis (PACE)  Academic Article
• Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes  Academic Article
• Analysis of hapten binding and catalytic determinants in a family of catalytic antibodies  Academic Article
• Analysis of structure-function relationships in the platelet membrane glycoprotein Ib-binding domain of von Willebrand's factor by expression of deletion mutants  Academic Article
• Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo  Academic Article
• Analysis of the class i aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99 Å resolution  Academic Article
• Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity  Academic Article
• Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera  Academic Article
• Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: Insight into the chaotrope unfolding dichotomy  Academic Article
• Anisotropic molecular rotational diffusion in n-15 spin relaxation studies of protein mobility  Academic Article
• Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists  Academic Article
• Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres  Academic Article
• Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones  Academic Article
• Anti-diabetic drug binding site in a mammalian K-ATP channel revealed by Cryo-EM  Academic Article
• Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen  Academic Article
• Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides  Academic Article
• Antibodies raised against beta-adrenergic receptors stimulate adenylate-cyclase  Academic Article
• Antibody 2g12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the hiv-1 glycan shield if domain exchanged  Academic Article
• Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike  Academic Article
• Antibody binding defines a structure for an epitope that participates in the prpc -> prpsc conformational change  Academic Article
• Antibody catalysis of the oxidation of water  Academic Article
• Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics  Academic Article
• Antibody microarrays utilizing site-specific antibody-oligonucleotide conjugates  Academic Article
• Antibody neutralization epitopes and integrin binding sites on nonenveloped viruses  Academic Article
• Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env  Academic Article
• Antibody structure and molecular immunology  Academic Article
• Antibody structure, diversity, and specificity  Academic Article
• Antibody vs. HIV in a clash of evolutionary titans  Academic Article
• Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions  Academic Article
• Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation  Academic Article
• Anticodon G recognition by tRNA synthetases mimics the tRNA core  Academic Article
• Antifungal azoles: structural insights into undesired tight binding to cholesterol-metabolizing CYP46A1  Academic Article
• Antigen recognition by variable lymphocyte receptors  Academic Article
• Antiidiotype and antihormone receptor antibodies  Academic Article
• Antimitotic agents of natural origin  Academic Article
• Ap-2/eps15 interaction is required for receptor-mediated endocytosis  Academic Article
• Apo raver1 structure reveals distinct RRM domain orientations  Academic Article
• Application of nuclear magnetic-resonance spectroscopy to proteins  Academic Article
• Approaches toward selective inhibition of nitric oxide synthase  Academic Article
• Aptly named aptamers display their aptitude  Academic Article
• Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation  Academic Article
• Archaeal flagellar atpase motor shows atp-dependent hexameric assembly and activity stimulation by specific lipid binding  Academic Article
• Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors  Academic Article
• Architecture of the mediator head module  Academic Article
• Arginine-54 in the active-site of escherichia-coli aspartate transcarbamoylase is critical for catalysis - a site-specific mutagenesis, NMR, and x-ray crystallographic study  Academic Article
• Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions  Academic Article
• Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor  Academic Article
• Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein  Academic Article
• Aspartate-transcarbamylase lacking catalytic subunit interactions - study of conformational-changes by uv absorbance and circular-dichroism spectroscopy  Academic Article
• Aspects of the molecular-structure of igg subclasses  Academic Article
• Assembly of hybrid bacteriophage Qβ virus-like particles  Academic Article
• Assembly of the ebola virus nucleoprotein from a chaperoned VP35 complex  Academic Article
• Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure  Academic Article
• Assessment of major and minor groove DNA interactions by the zinc fingers of xenopus transcription factor IIIA  Academic Article
• Association of Sindbis virus capsid protein with phospholipid membranes and the E2 glycoprotein: implications for alphavirus assembly  Academic Article
• Association of plasma apolipoproteins d with rbc membrane arachidonic acid levels in schizophrenia  Academic Article
• Association of the cytoplasmic domain of intercellular-adhesion molecule-1 with glyceraldehyde-3-phosphate dehydrogenase and beta-tubulin  Academic Article
• Asymmetric DNA binding by a homodimeric bHLH protein  Academic Article
• Asymmetric organic synthesis with catalytic antibodies  Academic Article
• Atomic and residue hydrophilicity in the context of folded protein structures  Academic Article
• Atomic coordinates and molecular-conformation of yeast phenylalanyl transfer-rna - independent investigation  Academic Article
• Atomic coordinates for triose phosphate isomerase from chicken muscle  Academic Article
• Atp induces conformational changes in the carboxyl-terminal region of clc-5  Academic Article
• Attachment of ribosome crystals to intracellular membranes  Academic Article
• Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor  Academic Article
• AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading  Academic Article
• AutoDock4(Zn): an improved AutoDock force field for small-molecule docking to zinc metalloproteins  Academic Article
• AutoDockFR: Advances in protein-ligand docking with explicitly specified binding site flexibility  Academic Article
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• Crystal structure of a divalent metal ion transporter CorA at 2.9 Å resolution  Academic Article
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• Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 Å resolution  Academic Article
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• Crystal structure of a putative NADPH-dependent oxidoreductase (GI : 18204011) from mouse at 2.10 Å resolution  Academic Article
• Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 Å resolution  Academic Article
• Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 a resolution  Academic Article
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• Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 Å resolution  Academic Article
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• Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 Å-resolution  Academic Article
• Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser  Academic Article
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• Crystal structure of the von Willebrand factor modulator botrocetin  Academic Article
• Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892  Academic Article
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• Crystal-structure of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f at 2.2 Å resolution  Academic Article
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• Genetic introduction of a diketone-containing amino acid into proteins  Academic Article
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• Influence of novel cd4 binding-defective hiv-1 envelope glycoprotein immunogens on neutralizing antibody and t-cell responses in nonhuman primates  Academic Article
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• Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands  Academic Article
• Inhibition of a viral enzyme by a small-molecule dimer disruptor  Academic Article
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• Inhibition of glutathione reductase by interaction of 2, 4, 6-trinitrobenzenesulfonate with the active-site dithiol  Academic Article
• Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site  Academic Article
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• Insights into PPAR gamma from structures with endogenous and covalently bound ligands  Academic Article
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• Interactions of Qβ replicase with Qβ RNA  Academic Article
• Interactions of active-site residues and catalytic activity of human carbonic anhydrase III  Academic Article
• Interactions of bovine neurophysin-II with oxytocin and 8-lysine vasopressin - high-resolution proton nuclear magnetic-resonance spectroscopy studies  Academic Article
• Interactions of soluble recombinant integrin alpha v beta 5 with human adenoviruses  Academic Article
• Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression  Academic Article
• Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta (C/EBP beta)  Academic Article
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• Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin  Academic Article
• Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells  Academic Article
• Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase  Academic Article
• Investigation of the PDZ domain ligand binding site using chemically modified peptides  Academic Article
• Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters  Academic Article
• Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein  Academic Article
• Involvement of an active-site Zn2+ ligand mechanism of human glyoxalase I  Academic Article
• Iron superoxide-dismutase from escherichia-coli at 3.1-a resolution - a structure unlike that of copper-zinc protein at both monomer and dimer levels  Academic Article
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• Isoform-selective and stereoselective inhibition of hypoxia inducible factor-2  Academic Article
• Isolated RNA binding domain of a class I tRNA synthetase  Academic Article
• Isolation and characterization of a collagen binding domain in human von Willebrand factor  Academic Article
• Isolation and characterization of maclura pomifera (mp) lectin  Academic Article
• Isolation and characterization of the DNA and protein binding activities of adenovirus core protein V  Academic Article
• Isolation and functional characterization of the von Willebrand factor-binding domain located between residues His1-Arg293 of the alpha-chain of glycoprotein Ib  Academic Article
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• Isolation of lectins of different specificities on a single affinity adsorbent  Academic Article
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• Isolation of the von Willebrand factor domain interacting with platelet glycoprotein Ib, heparin, and collagen and characterization of its three distinct functional sites  Academic Article
• Isothermal titration calorimetry and surface plasmon resonance allow quantifying substrate binding to different binding sites of Bacillus subtilis xylanase  Academic Article
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• Kinetic and spectroscopic evidence for three actomyosin : Adp states in smooth muscle  Academic Article
• Kinetic and stoichiometric characterisation of streptavidin-binding aptamers  Academic Article
• Kinetic independence of the subunits of cytosolic glutathione transferase from the rat  Academic Article
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• Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3 alpha 1  Academic Article
• Kinetic mechanism of RGS9-1 potentiation by R9AP  Academic Article
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• Kinetics and mechanisms of the oxidation of myoglobin by fe(iii) and cu(ii) complexes  Academic Article
• Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of udp-glcnac enolpyruvoyl transferase by the antibiotic fosfomycin  Academic Article
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• Kinomics: Characterizing the therapeutically validated kinase space  Academic Article
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• Metal-binding sites in proteins  Academic Article
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• Microbial glycan microarrays define key features of host-microbial interactions  Academic Article
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• Modular arrangement of functional domains along the sequence of an aminoacyl tRNA synthetase  Academic Article
• Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ib-alpha  Academic Article
• Modulation of lymphocyte receptor mobility by locally bound concanavalin-a  Academic Article
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• Molecular basis for p38 protein kinase inhibitor specificity  Academic Article
• Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity  Academic Article
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• Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta  Academic Article
• Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition  Academic Article
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• Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein  Academic Article
• Molecular cloning of Limulus alpha 2-macroglobulin  Academic Article
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• Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3  Academic Article
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• Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120  Academic Article
• Molecular mechanism for the umami taste synergism  Academic Article
• Molecular mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia - roles of conserved active site residues  Academic Article
• Molecular mechanism of the sweet taste enhancers  Academic Article
• Molecular modeling and crystal structure of ERK2-hypothemycin complexes  Academic Article
• Molecular probes of spermatozoan structures  Academic Article
• Molecular recognition and binding free energy calculations in drug development  Academic Article
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• Relaxation spectra of the iron spin transition in methemoglobin  Academic Article
• Repair complexes of fen1 endonuclease, DNA, and rad9-hus1-rad1 are distinguished from their pcna counterparts by functionally important stability  Academic Article
• Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure  Academic Article
• Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 2. Effects on heme coordination and function  Academic Article
• Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast  Academic Article
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• Residue met(156) contributes to the labile enzyme conformation of coagulation factor viia  Academic Article
• Residues in a class I tRNA synthetase which determine selectivity of amino acid recognition in the context of tRNA  Academic Article
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• Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin a  Academic Article
• Resynchronization of rna synthesis by coliphage qbeta replicase at an internal site of the rna template  Academic Article
• Reversal of ADP-mediated aggregation of adenosine kinase by cyclophilin leads to its reactivation  Academic Article
• Reversible regulation of tissue factor-induced coagulation by glycosyl phosphatidylinositol-anchored tissue factor pathway inhibitor  Academic Article
• Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains  Academic Article
• Rhombohedral crystals of the human vinculin head domain in complex with a vinculin-binding site of talin  Academic Article
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• Rigid body refinement of protein complexes with long-range distance restraints from pulsed dipolar ESR  Academic Article
• Role of DNA sequence in the binding specificity of synthetic basic-helix-loop-helix domains  Academic Article
• Role of RNA structure in arginine recognition of TAR RNA  Academic Article
• Role of Rab9 GTPase in facilitating receptor recruitment by TIP47  Academic Article
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• Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase  Academic Article
• Role of an active site adenine in hairpin ribozyme catalysis  Academic Article
• Role of an active site guanine in hairpin ribozyme catalysis probed by exogenous nucleobase rescue  Academic Article
• Role of aspartate-37 in determining cofactor specificity and binding in rat-liver dihydropteridine reductase  Academic Article
• Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization  Academic Article
• Role of cyclic nucleotides in central synaptic function  Academic Article
• Role of electrostatic interactions in PDZ domain ligand recognition  Academic Article
• Role of gtp hydrolysis in microtubule dynamics - information from a slowly hydrolyzable analog, gmpcpp  Academic Article
• Role of hydrogen bonding in the active site of human manganese superoxide dismutase  Academic Article
• Role of the glutamyl alpha-carboxylate of the substrate glutathione in the catalytic mechanism of human glutathione transferase A1-1  Academic Article
• Role of third intracellular loop of galanin receptor type 1 in signal transduction  Academic Article
• Role of tryptophan 161 in catalysis by human manganese superoxide dismutase  Academic Article
• Role of zymogen and activated factor x as scaffolds for the inhibition of the blood coagulation factor viia-tissue factor complex by recombinant nematode anticoagulant protein c2  Academic Article
• Roles of Dim2 in ribosome assembly  Academic Article
• Roles of IFN consensus sequence binding protein and PU.1 in regulating IL-18 gene expression  Academic Article
• Roles of bound quinone in the single subunit nadh-quinone oxidoreductase (ndi1) from saccharomyces cerevisiae  Academic Article
• Rotational correlation time of concanavalin-a after interaction with a fluorescent-probe  Academic Article
• Routes to catalysis - structure of a catalytic antibody and comparison with its natural counterpart  Academic Article
• Rrna-complementarity in the 5 ' untranslated region of mrna specifying the gtx homeodomain protein: Evidence that base-pairing to 18s rrna affects translational efficiency  Academic Article
• S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration  Academic Article
• S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death  Academic Article
• S1p(1)-selective in vivo-active agonists from high-throughput screening: Off-the-shelf chemical probes of receptor interactions, signaling, and fate  Academic Article
• SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2  Academic Article
• SDOCKER: A method utilizing existing X-ray structures to improve docking accuracy  Academic Article
• SIR1, an upstream component in auxin signaling identified by chemical genetics  Academic Article
• SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation  Academic Article
• SR2067 reveals a unique kinetic and structural signature for PPARγ partial agonism  Academic Article
• SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent  Academic Article
• STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells  Academic Article
• SUMO-binding motifs mediate the Rad60-dependent response to replicative stress and self-association  Academic Article
• SV40 T antigen interacts with Nbs1 to disrupt DNA replication control  Academic Article
• Saccharomyces cerevisiae lme2 phosphorylates Sic1 at multiple PXS/T sites but is insufficient to trigger Sic1 degradation  Academic Article
• Salicylates are interference compounds in TR-FRET assays  Academic Article
• Screening a peptidyl database for potential ligands to proteins with side-chain flexibility  Academic Article
• Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay  Academic Article
• Screening transthyretin amyloid fibril inhibitors: Characterization of novel multiprotein, multiligand complexes by mass spectrometry  Academic Article
• Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2  Academic Article
• Selecting against s1p(3) enhances the acute cardiovascular tolerability of 3-(n-benzyl)aminopropylphosphonic acid s1p receptor agonists  Academic Article
• Selection and application of peptide-binding peptides  Academic Article
• Selection by site-directed antibodies of small regions of peptides which are ordered in water  Academic Article
• Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms  Academic Article
• Selection of apoptotic cell specific human antibodies from adult bone marrow  Academic Article
• Selection pressure on hiv-1 envelope by broadly neutralizing antibodies to the conserved cd4-binding site  Academic Article
• Selective attenuation of the extrinsic limb of the tissue factor-driven coagulation protease cascade by occupancy of a novel peptidyl docking site on tissue factor  Academic Article
• Selective binding-site for (prostacyclin-h-3 on platelets  Academic Article
• Selective chemical catalysis by an antibody  Academic Article
• Selective inhibition of ADAR2-catalyzed editing of the serotonin 2c receptor pre-mRNA by a helix-threading peptide  Academic Article
• Selective interaction of heparin with the variable region 3 within surface glycoprotein of laboratory-adapted feline immunodeficiency virus  Academic Article
• Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120  Academic Article
• Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets  Academic Article
• Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for analysis of peptide hormone interactions with bovine neurophysin i using 13C nuclear magnetic-resonance spectroscopy  Academic Article
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• Sendai virus utilizes specific sialyloligosaccharides as host-cell receptor determinants  Academic Article
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• Sequence, structure and energetic determinants of phosphopeptide selectivity of SH2 domains  Academic Article
• Sequence-specific NMR assignment of proteins by global fragment mapping with the program mapper  Academic Article
• Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides  Academic Article
• Sequence-specific resonance assignments in the h-1-NMR spectrum of the lac repressor DNA-binding domain 1-51 from escherichia-coli by two-dimensional spectroscopy  Academic Article
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• Ser-884 adjacent to the lxxll motif of coactivator trbp defines selectivity for ers and trs  Academic Article
• Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations  Academic Article
• Serine hydrolase KIAA1363: Toxicological and structural features with emphasis on organophosphate interactions  Academic Article
• Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport  Academic Article
• Seven clues to the origin and structure of class-I ribonucleotide reductase intermediate X  Academic Article
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• Shigella applies molecular mimicry to subvert vinculin and invade host cells  Academic Article
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• Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells  Academic Article
• Side-chain conformational heterogeneity of intermediates in the Escherichia coli dihydrofolate reductase catalytic cycle  Academic Article
• Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells  Academic Article
• Significant structural and functional change of an antigen-binding site by a distant amino-acid substitution - proposal of a structural mechanism  Academic Article
• Simple method for production of specific xenoantisera to human histocompatibility (hla-a, hla-b, hla-c) antigens  Academic Article
• Simple reporter gene-based assays for hairpin poly(amide) conjugate permeability and DNA-binding activity in living cells  Academic Article
• Simultaneous binding of two proteins to opposite sides of a single transfer RNA  Academic Article
• Single sequence of a helix-loop peptide confers functional anticodon recognition on two tRNA synthetases  Academic Article
• Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR  Academic Article
• Single-step inline hydroxyapatite enrichment facilitates identification and quantitation of phosphopeptides from mass-limited proteomes with MudPIT  Academic Article
• Site-directed mutagenesis of the complement c5a receptor - examination of a model for its interaction with the ligand c5a  Academic Article
• Site-directed mutagenesis of the human beta(3)-adrenoceptor - transmembrane residues involved in ligand binding and signal transduction  Academic Article
• Site-selective cleavage of structured RNA by a Staphylococcal nuclease DNA hybrid  Academic Article
• Site-specific glycoconjugation of protein via bioorthogonal tetrazine cycloaddition with a genetically encoded trans-cyclooctene or bicyclononyne  Academic Article
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• Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept  Academic Article
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• Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport  Academic Article
• Small terminase couples viral DNA binding to genome-packaging ATPase activity  Academic Article
• Small-molecule binding to an artificially created cavity at the active-site of cytochrome-c peroxidase  Academic Article
• Small-molecule effectors of hepatitis b virus capsid assembly give insight into virus life cycle  Academic Article
• Small-molecule inhibitors of the c-Fes protein-tyrosine kinase  Academic Article
• Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity  Academic Article
• Sodium ion binding pocket mutations and adenosine A2A receptor function  Academic Article
• Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain  Academic Article
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• Solution structure of Escherichia coli glutaredoxin-2 shows similarity to mammalian glutathione-S-transferases  Academic Article
• Solution structure of rnase p rna  Academic Article
• Solution structure of sperm lysin yields novel insights into molecular dynamics of rapid protein evolution  Academic Article
• Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions  Academic Article
• Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP  Academic Article
• Solution structure of the cysteine-rich domain of the Escherichia coli chaperone protein DnaJ  Academic Article
• Solution structure of the kix domain of cbp bound to the transactivation domain of c-myb  Academic Article
• Solution structure of the third immunoglobulin domain of the neural cell adhesion molecule N-CAM: can solution studies define the mechanism of homophilic binding?  Academic Article
• Some new views of the cell surface  Academic Article
• Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization  Academic Article
• Spatially directed assembly of a heterotetrameric Cre-Lox synapse restricts recombination specificity  Academic Article
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• Specific fractionation of immune cell populations  Academic Article
• Specific killing of hiv-infected lymphocytes by a recombinant immunotoxin directed against the hiv-1 envelope glycoprotein  Academic Article
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• Spectroscopic characterization of the heme-binding sites in plasmodium falciparum histidine-rich protein 2  Academic Article
• Spectroscopic studies of the DNA-binding site of the gal4 zinc finger protein  Academic Article
• Sphingolipids as bioactive regulators of thrombin generation  Academic Article
• Spontaneous platelet aggregation in type IIB Tampa von Willebrand disease is inhibited by the 52/48-kDa fragment of normal von Willebrand factor, which contains the GPIb binding domain  Academic Article
• Stability of hairpin ribozyme tertiary structure is governed by the interdomain junction  Academic Article
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• Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3cl protease  Academic Article
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• Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway  Academic Article
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• Structural basis for specific inhibition of tRNA synthetase by an ATP competitive inhibitor  Academic Article
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• Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases  Academic Article
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• Structural basis of cell surface receptor recognition by botulinum neurotoxin B  Academic Article
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• Structural basis of single-nucleotide polymorphisms in cytochrome P450 2C9  Academic Article
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• Structural determinants of binding the seven-transmembrane domain of the glucagon-like peptide-1 receptor (GLP-1R)  Academic Article
• Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members  Academic Article
• Structural determinants of rotavirus subgroup specificity mapped by cryo-electron microscopy  Academic Article
• Structural dynamics of hiv-1 rev and its complexes with rre and 5s rna  Academic Article
• Structural evidence for substrate strain in antibody catalysis  Academic Article
• Structural features for functional selectivity at serotonin receptors  Academic Article
• Structural identification of the antibody-binding sites of hong-kong influenza hemagglutinin and their involvement in antigenic variation  Academic Article
• Structural insight into pH-induced conformational changes within the native human transthyretin tetramer  Academic Article
• Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants  Academic Article
• Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor  Academic Article
• Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein  Academic Article
• Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B  Academic Article
• Structural insights into protein-metal ion partnerships  Academic Article
• Structural insights into the avian aicar transformylase mechanism  Academic Article
• Structural insights into the evolution of an antibody combining site  Academic Article
• Structural insights into the function of the rab gdi superfamily  Academic Article
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• Structural insights into the molecular mechanism of h-nox activation  Academic Article
• Structural insights into the recognition of phosphopeptide by the FHA domain of kanadaptin  Academic Article
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• Structural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103  Academic Article
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• Structural mechanism of abscisic acid binding and signaling by dimeric PYR1  Academic Article
• Structural mimicry in the phage phi 21 N peptide-boxB RNA complex  Academic Article
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• Structural organization of complexes of transfer RNAs with aminoacyl transfer RNA synthetases  Academic Article
• Structural plasticity and the evolution of antibody affinity and specificity  Academic Article
• Structural properties of non-traditional drug targets present new challenges for virtual screening  Academic Article
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• Structural role of a buried salt bridge in the 434 repressor DNA-binding domain  Academic Article
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• Structural studies of atom-specific anticancer drugs acting on DNA  Academic Article
• Structural studies of cytochrome c-551 by h-1 NMR-spectroscopy at 360 mhz  Academic Article
• Structural studies of p21(waf1/cip1/sdi1) in the free and cdk2-bound state: Conformational disorder mediates binding diversity  Academic Article
• Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors  Academic Article
• Structural variations in species B adenovirus fibers impact CD46 association  Academic Article
• Structural-analysis of rauscher virus gp70 using monoclonal-antibodies - sites of antigenicity and p15(e) linkage  Academic Article
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• Structure analysis of peptide deformylases from Streptococcus pneumoniae, Staphylococcus aureus, Thermotoga maritima and Pseudomonas aeruginosa: Snapshots of the oxygen sensitivity of peptide deformylase  Academic Article
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• Structure and function of a genetically engineered mimic of a nonenveloped virus entry intermediate  Academic Article
• Structure and function of a novel LD-carboxypeptidase A involved in peptidoglycan recycling  Academic Article
• Structure and function of an unusual family of protein phosphatases: the bacterial chemotaxis proteins CheC and CheX  Academic Article
• Structure and function of helix-loop-helix proteins  Academic Article
• Structure and function of phage rna  Academic Article
• Structure and function of the von Willebrand factor A1 domain  Academic Article
• Structure and function of von Willebrand factor: relationship to von Willebrand's disease  Academic Article
• Structure and functional characterization of the rna-binding element of the nlrx1 innate immune modulator  Academic Article
• Structure and functional role of dynein's microtubule-binding domain  Academic Article
• Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634  Academic Article
• Structure and lytic activity of a bacillus anthracis prophage endolysin  Academic Article
• Structure and mechanism of copper, zinc superoxide-dismutase  Academic Article
• Structure and mechanism of the ruvb holliday junction branch migration motor  Academic Article
• Structure and mutational analysis of Rab GDP-dissociation inhibitor  Academic Article
• Structure and receptor specificity of the hemagglutinin from an h5n1 influenza virus  Academic Article
• Structure and thermodynamic characterization of the ephb4/ephrin-b2 antagonist peptide complex reveals the determinants for receptor specificity  Academic Article
• Structure at 0.85 Å resolution of an early protein photocycle intermediate  Academic Article
• Structure based prediction of subtype-selectivity for adenosine receptor antagonists  Academic Article
• Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes  Academic Article
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• Structure of SARS coronavirus spike receptor-binding domain complexed with receptor  Academic Article
• Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase  Academic Article
• Structure of Thermotoga maritima TM0439: Implications for the mechanism of bacterial GntR transcription regulators with Zn(2+)-binding FCD domains  Academic Article
• Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion  Academic Article
• Structure of a cation-bound multidrug and toxic compound extrusion transporter  Academic Article
• Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator  Academic Article
• Structure of a dicationic monoimidazole lexitropsin bound to DNA  Academic Article
• Structure of a kinesin microtubule depolymerization machine  Academic Article
• Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site  Academic Article
• Structure of a nitric oxide synthase heme protein from Bacillus subtilis  Academic Article
• Structure of a protein photocycle intermediate by millisecond time-resolved crystallography  Academic Article
• Structure of a thioredoxin-like 2fe-2s ferredoxin from aquifex aeolicus  Academic Article
• Structure of a trimeric nucleoporin complex reveals alternate oligomerization states  Academic Article
• Structure of a v3-containing hiv-1 gp120 core  Academic Article
• Structure of activated aconitase - formation of the 4fe-4s cluster in the crystal  Academic Article
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• Structure of an agonist-bound human A₂A adenosine receptor  Academic Article
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• Structure of avian aicar transformylase with a multisubstrate adduct inhibitor β-DADF identifies the folate binding site  Academic Article
• Structure of azotobacter vinelandii 7fe ferredoxin at 1.35 Å resolution and determination of the fe-s bonds with 0.01 Å accuracy  Academic Article
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