subject area of

• 1.35 and 2.07 a resolution structures of the red abalone sperm lysin monomer and dimer reveal features involved in receptor binding  Academic Article
• 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase  Academic Article
• 2,5-diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3)  Academic Article
• 2-(3,5-dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor  Academic Article
• 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport  Academic Article
• 3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting  Academic Article
• 3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle  Academic Article
• 3D domain swapping modulates the stability of members of an icosahedral virus group  Academic Article
• 4-Aminoindazolyl-dihydrofuro 3,4-d pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase  Academic Article
• A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs  Academic Article
• A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis  Academic Article
• A base triple in the tetrahymena group i core affects the reaction equilibrium via a threshold effect  Academic Article
• A binding site for homeodomain and pax proteins is necessary for l1 cell adhesion molecule gene expression by pax-6 and bone morphogenetic proteins  Academic Article
• A binding site for pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord  Academic Article
• A branching reaction mechanism of glutathione reductase  Academic Article
• A brassinosteroid transcriptional network revealed by genome-wide identification of BESI target genes in Arabidopsis thaliana  Academic Article
• A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding  Academic Article
• A cell cycle phosphoproteome of the yeast centrosome  Academic Article
• A chemical, genetic, and structural analysis of the nuclear bile acid receptor fxr  Academic Article
• A chemically functionalized magnetic nanoplatform for rapid and specific biomolecular recognition and separation  Academic Article
• A chromatin binding-site in the tail domain of nuclear lamins that interacts with core histones  Academic Article
• A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease  Academic Article
• A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPAR gamma partial agonists  Academic Article
• A complex assembly landscape for the 30S ribosomal subunit  Academic Article
• A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis  Academic Article
• A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles  Academic Article
• A conserved hiv gp120 glycoprotein structure involved in chemokine receptor binding  Academic Article
• A conserved motif in the itk ph-domain is required for phosphoinositide binding and tcr signaling but dispensable for adaptor protein interactions  Academic Article
• A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase  Academic Article
• A de novo designed peptide ligase: A mechanistic investigation  Academic Article
• A de novo protein binding pair by computational design and directed evolution  Academic Article
• A density functional evaluation of an Fe(III)-Fe(IV) model diiron cluster: comparisons with ribonucleotide reductase intermediate X  Academic Article
• A designed inhibitor of a CLC antiporter blocks function through a unique binding mode  Academic Article
• A designed synthetic analogue of 4-OT is specific for a non-natural substrate  Academic Article
• A detailed structural model of cytotactin - protein homologies, alternative rna splicing, and binding regions  Academic Article
• A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons  Academic Article
• A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120  Academic Article
• A dynamic search process underlies microRNA targeting  Academic Article
• A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol)  Academic Article
• A flexible interface between DNA ligase and pcna supports conformational switching and efficient ligation of DNA  Academic Article
• A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking  Academic Article
• A four-helical super-secondary structure  Academic Article
• A fragment of human TrpRS as a potent antagonist of ocular angiogenesis  Academic Article
• A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia-coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases  Academic Article
• A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock  Academic Article
• A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding  Academic Article
• A g-protein alpha-subunit from asexual candida-albicans functions in the mating signal transduction pathway of saccharomyces-cerevisiae and is regulated by the a1-alpha-2 repressor  Academic Article
• A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain  Academic Article
• A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells  Academic Article
• A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans  Academic Article
• A genetically encoded diazirine photocrosslinker in Escherichia coli  Academic Article
• A genetically encoded fluorescent amino acid  Academic Article
• A global benchmark study using affinity-based biosensors  Academic Article
• A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728  Academic Article
• A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B  Academic Article
• A hierarchy of RNA subdomains in assembly of the central domain of the 30 S ribosomal subunit  Academic Article
• A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs  Academic Article
• A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein  Academic Article
• A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS  Academic Article
• A linear amino acid sequence involved in the interaction of t-PA with its endothelial cell receptor  Academic Article
• A method for defining binding sites involved in protein-protein interactions: analysis of the binding of plasminogen activator inhibitor 1 to the somatomedin domain of vitronectin  Academic Article
• A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase  Academic Article
• A mutation in the human cyclin-dependent kinase interacting protein, ckshs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly  Academic Article
• A new decoration for nitric oxide synthase - a zn(cys)4 site  Academic Article
• A new mechanism of allostery in a G protein-coupled receptor dimer  Academic Article
• A new model for binding of kinesin 13 to curved microtubule protofilaments  Academic Article
• A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic c-1027 biosynthesis  Academic Article
• A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A  Academic Article
• A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase  Academic Article
• A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties  Academic Article
• A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma  Academic Article
• A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va  Academic Article
• A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1  Academic Article
• A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex  Academic Article
• A novel role of the budding yeast separin esp1 in anaphase spindle elongation: Evidence that proper spindle association of esp1 is regulated by pds1  Academic Article
• A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity  Academic Article
• A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site  Academic Article
• A permutational approach toward protein-DNA recognition  Academic Article
• A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis  Academic Article
• A poly(A) binding protein functions in the chloroplast as a message-specific translation factor  Academic Article
• A positive feedback loop controls transcription of the spoof gene, a component of the sporulation phosphorelay in bacillus-subtilis  Academic Article
• A protein-S binding-site on C4b-binding protein involves beta-chain residues 31-45  Academic Article
• A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.Fem-3 mRNA complex  Academic Article
• A random walk in oncogene space: The quest for targets  Academic Article
• A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation  Academic Article
• A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin  Academic Article
• A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria  Academic Article
• A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: Crystal structure of spo0f from bacillus subtilis  Academic Article
• A retroviral-like metal binding motif in an aminoacyl-tRNA synthetase is important for tRNA recognition  Academic Article
• A reversible reaction inside a self-assembled capsule  Academic Article
• A ribozyme composed of only two different nucleotides  Academic Article
• A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus  Academic Article
• A role for ranbp1 in the release of crm1 from the nuclear pore complex in a terminal step of nuclear export  Academic Article
• A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280  Academic Article
• A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib  Academic Article
• A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis  Academic Article
• A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases  Academic Article
• A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta  Academic Article
• A semisynthetic glutathione peroxidase with high catalytic efficiency: Selenoglutathione transferase  Academic Article
• A shape-dependent hydrophobic effect for tetrazoles  Academic Article
• A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth  Academic Article
• A silencer element in the retinoblastoma tumor-suppressor gene  Academic Article
• A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity  Academic Article
• A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure  Academic Article
• A single gal4 dimer can maximally activate transcription under physiological conditions  Academic Article
• A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors  Academic Article
• A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases  Academic Article
• A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases  Academic Article
• A small molecule inhibitor selective for a variant atp-binding site of the chaperonin groel  Academic Article
• A source of response regulator autophosphatase activity: The critical role of a residue adjacent to the spo0f autophosphorylation active site  Academic Article
• A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor  Academic Article
• A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle  Academic Article
• A sphingosine 1-phosphate receptor 2 selective allosteric agonist  Academic Article
• A stapled p53 helix overcomes HDMX-mediated suppression of p53  Academic Article
• A steady-state kinetic model of butyrylcholinesterase from horse plasma  Academic Article
• A steady-state-kinetic random mechanism for glutathione S-transferase A from rat liver. A model involving kinetically significant enzyme-product complexes in the forward reaction  Academic Article
• A structural model for the high-valent intermediate Q of methane monooxygenase from broken-symmetry density functional and electrostatics calculations  Academic Article
• A structural model for the prostate disease marker, human prostate-specific antigen  Academic Article
• A structural perspective of the sequence variability within botulinum neurotoxin subtypes a1-a4  Academic Article
• A structure-activity study of nociceptin-(1-13)-peptide amide. Synthesis of analogues substituted in positions 0, 1, 3, 4 and 10  Academic Article
• A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase  Academic Article
• A synthetic receptor for phosphocholine esters  Academic Article
• A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease  Academic Article
• A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen  Academic Article
• A translation-like cycle is a quality control checkpoint for maturing 40s ribosome subunits  Academic Article
• A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5  Academic Article
• A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry  Academic Article
• A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin mac-1 (cd11b cd18)  Academic Article
• A universal entropy-driven mechanism for thioredoxin-target recognition  Academic Article
• A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities  Academic Article
• ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair  Academic Article
• ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization  Academic Article
• ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase  Academic Article
• Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: The 3 ' ends justify the means  Academic Article
• Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: Formation of a pterin radical is required for enzyme activity  Academic Article
• Ablating adenovirus type 5 fiber-car binding and hi loop insertion of the sigyplp peptide generate an endothelial cell-selective adenovirus  Academic Article
• Absence of G(i) proteins in the Sf9 insect cell. Characterization of the uncoupled recombinant N-formyl peptide receptor  Academic Article
• Acceptor helix interactions in a class II tRNA synthetase: photoaffinity cross-linking of an RNA miniduplex substrate  Academic Article
• Acceptor substrate-based selective inhibition of galactosyltransferases  Academic Article
• Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gpl120 is sterically restricted on primary human immunodeficiency virus type 1  Academic Article
• Accessibility of nuclear chromatin by DNA binding polyamides  Academic Article
• Acetylcholine recognition by a deep, biomimetic pocket  Academic Article
• Acidophilic adaptations in the structure of Acetobacter aceti N-5-carboxyaminoimidazole ribonucleotide mutase (PurE)  Academic Article
• Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements  Academic Article
• Activation of Hageman factor in solid and fluid phases. A critical role of kallikrein  Academic Article
• Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1  Academic Article
• Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete c-terminal domain  Academic Article
• Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the a subunits  Academic Article
• Activation of the redox-regulated chaperone hsp33 by domain unfolding  Academic Article
• Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation  Academic Article
• Active and alkylated human agt structures: A novel zinc site, inhibitor and extrahelical base binding  Academic Article
• Active and inhibited human catalase structures: Ligand and nadph binding and catalytic mechanism  Academic Article
• Active site binding modes of curcumin in HIV-1 protease and integrase  Academic Article
• Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense  Academic Article
• Active site modification of factor viia affects interactions of the protease domain with tissue factor  Academic Article
• Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein  Academic Article
• Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties  Academic Article
• Active site residues of cyclophilin A are crucial for its signaling activity via CD147  Academic Article
• Active site structure of Rieske-type proteins: electron nuclear double resonance studies of isotopically labeled phthalate dioxygenase from Pseudomonas cepacia and Rieske protein from Rhodobacter capsulatus and molecular modeling studies of a Rieske center  Academic Article
• Active site structure of class I ribonucleotide reductase intermediate X: a density functional theory analysis of structure, energetics, and spectroscopy  Academic Article
• Active site-directed inhibition of rabbit cytochrome P-450 1 by amino-substituted steroids  Academic Article
• Active thymus derived suppressor lymphocytes in human cord blood  Academic Article
• Active, interactive, and inactive steroid-receptor mutants  Academic Article
• Active-site and oligosaccharide recognition residues of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f  Academic Article
• Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3  Academic Article
• Activity-based protein profiling for the functional annotation of enzymes  Academic Article
• Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid)  Academic Article
• Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2  Academic Article
• Adding L-3-(2-naphthyl)alanine to the genetic code of E. coli  Academic Article
• Addition of an alpha-hydroxy acid to the genetic code of bacteria  Academic Article
• Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope  Academic Article
• Adenosine: a partial agonist of the growth hormone secretagogue receptor  Academic Article
• Adhesive properties of the isolated amino-terminal domain of platelet glycoprotein Ib alpha in a flow field  Academic Article
• Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenge  Academic Article
• Advances in pain therapeutics  Academic Article
• Affinity labeling of creatine kinase by N-(2,3-epoxypropyl)-N-amidinoglycine  Academic Article
• Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling  Academic Article
• Agonist-bound structure of the human P2Y(12) receptor  Academic Article
• Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence  Academic Article
• Alanine scanning mutagenesis of an alpha beta T cell receptor: mapping the energy of antigen recognition  Academic Article
• Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA  Academic Article
• Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition  Academic Article
• Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase  Academic Article
• Aldehyde dehydrogenase inhibitors: A comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application  Academic Article
• Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors  Academic Article
• Allosteric inhibition of hypoxia inducible factor-2 with small molecules  Academic Article
• Allosteric inhibition via R-state destabilization in ATP sulfurylase from Penicillium chrysogenum  Academic Article
• Alternative outcomes in assembly of promoter complexes: The roles of TBP and a flexible linker in placing TFIIIB on tRNA genes  Academic Article
• Amino acid derived quinazolines as Rock/PKA inhibitors  Academic Article
• Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles  Academic Article
• Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib  Academic Article
• Amino acid substitution at the dimeric interface of human manganese superoxide dismutase  Academic Article
• Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase  Academic Article
• Aminoacylation of RNA minihelices: implications for tRNA synthetase structural design and evolution  Academic Article
• Aminoglycoside binding in the major groove of duplex rna: The thermodynamic and electrostatic forces that govern recognition  Academic Article
• Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase  Academic Article
• An AP-1 site is involved in the NGF induction of IL-1α in PC12 cells  Academic Article
• An L-RNA aptamer that binds and inhibits RNase  Academic Article
• An NMR perspective on enzyme dynamics  Academic Article
• An RNA binding site in a tRNA synthetase with a reduced set of amino acids  Academic Article
• An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors  Academic Article
• An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide  Academic Article
• An acyloxymethyl ketone-based probe to monitor the activity of glutathionylspermidine amidase in Escherichia coli  Academic Article
• An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1  Academic Article
• An alternate binding site for PPARγ ligands  Academic Article
• An alternative processing of integrin αv subunit in tumor cells by membrane type-1 matrix metalloproteinase  Academic Article
• An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance  Academic Article
• An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode  Academic Article
• An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription  Academic Article
• An analysis of a class of DNA sequence reading molecules  Academic Article
• An aptamer that neutralizes r5 strains of hiv-1 binds to core residues of gp120 in the ccr5 binding site  Academic Article
• An aptamer that neutralizes r5 strains of human immunodeficiency virus type 1 blocks gp120-ccr5 interaction  Academic Article
• An engineered mutant of hiv-1 gp120 formulated with adjuvant quil a promotes elicitation of antibody responses overlapping the cd4-binding site  Academic Article
• An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured  Academic Article
• An essential histidine residue in the catalytic mechanism of mammalian glutathione reductase  Academic Article
• An essential role for the conserved Glu-133 in the anion interaction with superoxide-dismutase  Academic Article
• An evolutionary approach to the design of glutathione-linked enzymes  Academic Article
• An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity  Academic Article
• An improved zinc-finger nuclease architecture for highly specific genome editing  Academic Article
• An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation  Academic Article
• An inhibitor of sequence-specific proteolysis that targets the substrate rather than the enzyme  Academic Article
• An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity  Academic Article
• An intramolecular signaling element that modulates dynamin function in vitro and in vivo  Academic Article
• An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin 5  Academic Article
• An o-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses  Academic Article
• An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution  Academic Article
• An operational RNA code for amino acids and variations in critical nucleotide sequences in evolution  Academic Article
• An oxetane-based polyketide surrogate To probe substrate binding in a polyketide synthase  Academic Article
• An unusual dimeric structure and assembly for tlr4 regulator rp105-md-1  Academic Article
• Analysis of bacteriophage N protein and peptide binding to boxB RNA using polyacrylamide gel coelectrophoresis (PACE)  Academic Article
• Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes  Academic Article
• Analysis of hapten binding and catalytic determinants in a family of catalytic antibodies  Academic Article
• Analysis of structure-function relationships in the platelet membrane glycoprotein Ib-binding domain of von Willebrand's factor by expression of deletion mutants  Academic Article
• Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo  Academic Article
• Analysis of the class i aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99 Å resolution  Academic Article
• Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity  Academic Article
• Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera  Academic Article
• Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: Insight into the chaotrope unfolding dichotomy  Academic Article
• Anisotropic molecular rotational diffusion in n-15 spin relaxation studies of protein mobility  Academic Article
• Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists  Academic Article
• Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres  Academic Article
• Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones  Academic Article
• Anti-diabetic drug binding site in a mammalian K-ATP channel revealed by Cryo-EM  Academic Article
• Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen  Academic Article
• Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides  Academic Article
• Antibodies raised against beta-adrenergic receptors stimulate adenylate-cyclase  Academic Article
• Antibody 2g12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the hiv-1 glycan shield if domain exchanged  Academic Article
• Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike  Academic Article
• Antibody binding defines a structure for an epitope that participates in the prpc -> prpsc conformational change  Academic Article
• Antibody catalysis of the oxidation of water  Academic Article
• Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics  Academic Article
• Antibody microarrays utilizing site-specific antibody-oligonucleotide conjugates  Academic Article
• Antibody neutralization epitopes and integrin binding sites on nonenveloped viruses  Academic Article
• Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env  Academic Article
• Antibody structure and molecular immunology  Academic Article
• Antibody structure, diversity, and specificity  Academic Article
• Antibody vs. HIV in a clash of evolutionary titans  Academic Article
• Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions  Academic Article
• Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation  Academic Article
• Anticodon G recognition by tRNA synthetases mimics the tRNA core  Academic Article
• Antifungal azoles: structural insights into undesired tight binding to cholesterol-metabolizing CYP46A1  Academic Article
• Antigen recognition by variable lymphocyte receptors  Academic Article
• Antiidiotype and antihormone receptor antibodies  Academic Article
• Antimitotic agents of natural origin  Academic Article
• Ap-2/eps15 interaction is required for receptor-mediated endocytosis  Academic Article
• Apo raver1 structure reveals distinct RRM domain orientations  Academic Article
• Application of nuclear magnetic-resonance spectroscopy to proteins  Academic Article
• Approaches toward selective inhibition of nitric oxide synthase  Academic Article
• Aptly named aptamers display their aptitude  Academic Article
• Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation  Academic Article
• Archaeal flagellar atpase motor shows atp-dependent hexameric assembly and activity stimulation by specific lipid binding  Academic Article
• Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors  Academic Article
• Architecture of the mediator head module  Academic Article
• Arginine-54 in the active-site of escherichia-coli aspartate transcarbamoylase is critical for catalysis - a site-specific mutagenesis, NMR, and x-ray crystallographic study  Academic Article
• Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions  Academic Article
• Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor  Academic Article
• Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein  Academic Article
• Aspartate-transcarbamylase lacking catalytic subunit interactions - study of conformational-changes by uv absorbance and circular-dichroism spectroscopy  Academic Article
• Aspects of the molecular-structure of igg subclasses  Academic Article
• Assembly of hybrid bacteriophage Qβ virus-like particles  Academic Article
• Assembly of the ebola virus nucleoprotein from a chaperoned VP35 complex  Academic Article
• Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure  Academic Article
• Assessment of major and minor groove DNA interactions by the zinc fingers of xenopus transcription factor IIIA  Academic Article
• Association of Sindbis virus capsid protein with phospholipid membranes and the E2 glycoprotein: implications for alphavirus assembly  Academic Article
• Association of plasma apolipoproteins d with rbc membrane arachidonic acid levels in schizophrenia  Academic Article
• Association of the cytoplasmic domain of intercellular-adhesion molecule-1 with glyceraldehyde-3-phosphate dehydrogenase and beta-tubulin  Academic Article
• Asymmetric DNA binding by a homodimeric bHLH protein  Academic Article
• Asymmetric organic synthesis with catalytic antibodies  Academic Article
• Atomic and residue hydrophilicity in the context of folded protein structures  Academic Article
• Atomic coordinates and molecular-conformation of yeast phenylalanyl transfer-rna - independent investigation  Academic Article
• Atomic coordinates for triose phosphate isomerase from chicken muscle  Academic Article
• Atp induces conformational changes in the carboxyl-terminal region of clc-5  Academic Article
• Attachment of ribosome crystals to intracellular membranes  Academic Article
• Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor  Academic Article
• AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading  Academic Article
• AutoDock4(Zn): an improved AutoDock force field for small-molecule docking to zinc metalloproteins  Academic Article
• AutoDockFR: Advances in protein-ligand docking with explicitly specified binding site flexibility  Academic Article
• Autoactivation of avian urokinase-type plasminogen activator (upa) - a novel mode of initiation of the upa/plasmin cascade  Academic Article
• Automated docking in crystallography: analysis of the substrates of aconitase  Academic Article
• Automated docking of ligands to an artificial active site: augmenting crystallographic analysis with computer modeling  Academic Article
• Automated docking of substrates to proteins by simulated annealing  Academic Article
• Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase  Academic Article
• Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications  Academic Article
• Automated identification of functional dynamic contact networks from X-ray crystallography  Academic Article
• Automated prediction of ligand-binding sites in proteins  Academic Article
• Avian winged helix proteins CWH-1, CWH-2 and CWH-3 repress transcription from Qin binding sites  Academic Article
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• Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution  Academic Article
• Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch  Academic Article
• Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design  Academic Article
• Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design  Academic Article
• Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 Å resolution  Academic Article
• Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 Å resolution  Academic Article
• Crystal structure of a phosphatase-resistant mutant of sporulation response regulator spo0f from bacillus subtilis  Academic Article
• Crystal structure of a putative NADPH-dependent oxidoreductase (GI : 18204011) from mouse at 2.10 Å resolution  Academic Article
• Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 Å resolution  Academic Article
• Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 a resolution  Academic Article
• Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3  Academic Article
• Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 Å resolution  Academic Article
• Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design  Academic Article
• Crystal structure of an isolated V(alpha) domain of the 2C T-cell receptor  Academic Article
• Crystal structure of antagonist bound human lysophosphatidic acid receptor 1  Academic Article
• Crystal structure of atp sulfurylase from penicillium chrysogenum: Insights into the allosteric regulation of sulfate assimilation  Academic Article
• Crystal structure of botulinum neuro-toxin type a and implications for toxicity  Academic Article
• Crystal structure of botulinum neurotoxin type g light chain: Serotype divergence in substrate recognition  Academic Article
• Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5  Academic Article
• Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition  Academic Article
• Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping  Academic Article
• Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue  Academic Article
• Crystal structure of human ornithine transcarbamylase complexed with carbamoyl phosphate and L-norvaline at 1.9 A resolution  Academic Article
• Crystal structure of human toll-like receptor 3 (tlr3) ectodomain  Academic Article
• Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites  Academic Article
• Crystal structure of human vinculin  Academic Article
• Crystal structure of misoprostol bound to the labor inducer prostaglandin E-2 receptor  Academic Article
• Crystal structure of mouse cd1: An mhc-like fold with a large hydrophobic binding groove  Academic Article
• Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 Å-resolution  Academic Article
• Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser  Academic Article
• Crystal structure of soluble md-1 and its interaction with lipid iva  Academic Article
• Crystal structure of the 100 kda arsenite oxidase from alcaligenes faecalis in two crystal forms at 1.64 Å and 2.03 Å  Academic Article
• Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution  Academic Article
• Crystal structure of the Frizzled 4 receptor in a ligand-free state  Academic Article
• Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose  Academic Article
• Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide  Academic Article
• Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran  Academic Article
• Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding  Academic Article
• Crystal structure of the broadly cross-reactive hiv-1-neutralizing fab x5 and fine mapping of its epitope  Academic Article
• Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin a  Academic Article
• Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a k(+) channel inhibitor-like fold  Academic Article
• Crystal structure of the human 4-1BB/4-1BBL complex  Academic Article
• Crystal structure of the human TRPV2 channel ankyrin repeat domain  Academic Article
• Crystal structure of the lactose operon repressor and its complexes with DNA and inducer  Academic Article
• Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A  Academic Article
• Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of camp-dependent protein kinase  Academic Article
• Crystal structure of the spindle assembly checkpoint protein Bub3  Academic Article
• Crystal structure of the transcriptional repressor pagr of bacillus anthracis  Academic Article
• Crystal structure of the von Willebrand factor modulator botrocetin  Academic Article
• Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892  Academic Article
• Crystal structure of tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex  Academic Article
• Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases  Academic Article
• Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 Å resolution: Self-hydroxylation of phe300 and the pterin-binding site  Academic Article
• Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin  Academic Article
• Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34  Academic Article
• Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis  Academic Article
• Crystal structures of a quorum-quenching antibody  Academic Article
• Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP  Academic Article
• Crystal structures of apolipoprotein(a) kringle iv37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: Existence of novel and expected binding modes  Academic Article
• Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases  Academic Article
• Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR  Academic Article
• Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates  Academic Article
• Crystal structures of human topoisomerase i in covalent and noncovalent complexes with DNA  Academic Article
• Crystal structures of leukotriene a(4) hydrolase in complex with captopril and two competitive tight-binding inhibitors  Academic Article
• Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands  Academic Article
• Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors  Academic Article
• Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain  Academic Article
• Crystal structures of the free and liganded form of an esterolytic catalytic antibody  Academic Article
• Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor  Academic Article
• Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake  Academic Article
• Crystal structures of transhydrogenase domain i with and without bound nadh  Academic Article
• Crystal structures of two I-A(d)-peptide complexes reveal that high affinity can be achieved without large anchor residues  Academic Article
• Crystal structures of two rat mhc class ia (rt1-a) molecules that are associated differentially with peptide transporter alleles tap-a and tap-b  Academic Article
• Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains  Academic Article
• Crystal-structure and mutational analysis of human uracil-DNA glycosylase - structural basis for specificity and catalysis  Academic Article
• Crystal-structure of an h-2k(b)-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove  Academic Article
• Crystal-structure of cd,zn metallothionein  Academic Article
• Crystal-structure of human uracil-DNA glycosylase in complex with a protein inhibitor - protein mimicry of DNA  Academic Article
• Crystal-structure of murine cyclophilin-c complexed with immunosuppressive drug cyclosporine-a  Academic Article
• Crystal-structure of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f at 2.2 Å resolution  Academic Article
• Crystal-structure of the human cell-cycle protein ckshs1 - single-domain fold with similarity to kinase n-lobe domain  Academic Article
• Crystal-structures of 2 viral peptides in complex with murine mhc class-i h-2k(b)  Academic Article
• Crystal-structures of a schistosomal drug and vaccine target - glutathione-s-transferase from schistosoma-japonica and its complex with the leading antischistosomal drug praziquantel  Academic Article
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• Crystal-structures of aconitase with trans-aconitate and nitrocitrate bound  Academic Article
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• Crystallographic analysis of 2 site-directed mutants of azotobacter-vinelandii ferredoxin  Academic Article
• Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG  Academic Article
• Crystallographic fragment-based drug discovery: use of a brominated fragment library targeting HIV protease  Academic Article
• Cu,Zn superoxide dismutase structure from a microbial pathogen establishes a class with a conserved dimer interface  Academic Article
• Curariform antagonists bind in different orientations to acetylcholine-binding protein  Academic Article
• Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins  Academic Article
• Custom zinc-finger nucleases for use in human cells  Academic Article
• Cyclic and linear oligocarbamate ligands for human thrombin  Academic Article
• Cyclin-dependent kinases 5 template: useful for virtual screening  Academic Article
• Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation  Academic Article
• Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site  Academic Article
• Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites  Academic Article
• Cys-X scanning for expansion of active-site residues and modulation of catalytic functions in a glutathione transferase  Academic Article
• CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis  Academic Article
• Cysteine residues are not essential for the catalytic activity of human class Mu glutathione transferase M1a-1a  Academic Article
• Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import  Academic Article
• Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif  Academic Article
• D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain  Academic Article
• DNA apurinic-apyrimidinic site binding and excision by endonuclease iv  Academic Article
• DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex  Academic Article
• DNA binding and nucleotide flipping by the human DNA repair protein agt  Academic Article
• DNA loops induced by cooperative binding of transcriptional activator proteins and preinitiation complexes  Academic Article
• DNA protein complexes during attachment-site synapsis in Mu DNA transposition  Academic Article
• DNA recognition by a σ(54) transcriptional activator from Aquifex aeolicus  Academic Article
• DNA sequence-directed nucleosome reconstitution on 5S RNA genes of Xenopus-laevis  Academic Article
• DNA-binding proteins in human-serum  Academic Article
• DNA-induced alpha-helix capping in conserved linker sequences is a determinant of binding affinity in Cys(2)-His(2) zinc fingers  Academic Article
• DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes  Academic Article
• De novo computational design of retro-aldol enzymes  Academic Article
• Deep cavitands provide organized solvation of reactions  Academic Article
• Defining GC-specificity in the minor groove: Side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G  Academic Article
• Defining the communication between agonist and coactivator binding in the retinoid X receptor alpha ligand binding domain  Academic Article
• Definition of the binding-sites of individual zinc fingers in the transcription factor-IIIA-5S RNA gene-complex  Academic Article
• Delineation of spontaneous erythrocyte autoantibody responses of nzb and other strains of mice  Academic Article
• Delineation of the peptide binding site of the human galanin receptor  Academic Article
• Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: Noncovalent binding coincidental with alkylation  Academic Article
• Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit  Academic Article
• Demonstration of circulating immune complexes in Sjögren's syndrome  Academic Article
• Density functional and electrostatics study of oxidized and reduced ribonucleotide reductase: comparisons with methane monooxygenase  Academic Article
• Density functional calculation of pKa values and redox potentials in the bovine Rieske iron-sulfur protein  Academic Article
• Density functional studies of oxidized and reduced methane monooxygenase. Optimized geometries and exchange coupling of active site clusters  Academic Article
• Density functional theory study of Fe(IV) d-d optical transitions in active-site models of class I ribonucleotide reductase intermediate X with vertical self-consistent reaction field methods  Academic Article
• Derivation of a retinoid x receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1h-indol-3-yl)methyl-4-trifluoromethylbenzene  Academic Article
• Design and characterization of an active site selective caspase-3 transnitrosating agent  Academic Article
• Design and evolution of new catalytic activity with an existing protein scaffold  Academic Article
• Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives  Academic Article
• Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300  Academic Article
• Design and synthesis of c5 methylated l-arginine analogues as active site probes for nitric oxide synthase  Academic Article
• Design and synthesis of novel CCR2 antagonists: Investigation of non-aryl/heteroaryl binding motifs  Academic Article
• Design and synthesis of selenazole-containing peptides for cocrystallization with p-glycoprotein  Academic Article
• Design of a functional membrane protein by engineering a heme-binding site in glycophorin A  Academic Article
• Design of a redox-linked active metal site: manganese bound to bacterial reaction centers at a site resembling that of photosystem II  Academic Article
• Design of allele-specific protein methyltransferase inhibitors  Academic Article
• Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d  Academic Article
• Design of polydactyl zinc-finger proteins for unique addressing within complex genomes  Academic Article
• Design of potent and selective 2-aminobenzimidazole-based p38 alpha MAP kinase inhibitors with excellent in vivo efficacy  Academic Article
• Design of stapled DNA-minor-groove-binding molecules with a mutable atom simulated annealing method  Academic Article
• Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors  Academic Article
• Design, synthesis and evaluation of 2,5-diketopiperazines as inhibitors of the MDM2-p53 interaction  Academic Article
• Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors  Academic Article
• Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants  Academic Article
• Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators  Academic Article
• Designing small-molecule switches for protein-protein interactions  Academic Article
• Designing transcription factor architectures for drug discovery  Academic Article
• Detection of a catalytic antibody species acylated at the active site by electrospray mass spectrometry  Academic Article
• Detection of a ternary complex of nf-kappa b and i kappa b alpha with DNA provides insights into how i kappa b alpha removes nf-kappa b from transcription sites  Academic Article
• Detection of leucine-independent DNA site occupancy of the yeast Leu3p transcriptional activator in vivo  Academic Article
• Determinants of DNA mismatch recognition within the polymerase domain of the klenow fragment  Academic Article
• Determinants of cytochrome P4502C8 substrate binding - structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid  Academic Article
• Determination and analysis of the 2A structure of copper, zinc superoxide-dismutase  Academic Article
• Determination of matrix metalloproteinase activity using biotinylated gelatin  Academic Article
• Determination of the 3-dimensional structure of metallothioneins by nuclear-magnetic-resonance spectroscopy in solution  Academic Article
• Determination of the NMR solution structure of the cyclophilin-a - cyclosporine-a complex  Academic Article
• Determination of the coordination geometry at the heme iron in 3 cytochromes-c from saccharomyces-cerevisiae and from candida-krusei based on individual h-1-NMR assignments for heme-c and the axially coordinated amino-acids  Academic Article
• Determination of the nuclear-magnetic-resonance solution structure of the DNA-binding domain (residues 1 to 69) of the 434 repressor and comparison with the x-ray crystal-structure  Academic Article
• Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface  Academic Article
• Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair  Academic Article
• Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor  Academic Article
• Development of 5N-bicalutamide, a high-affinity reversible covalent antiandrogen  Academic Article
• Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors  Academic Article
• Development of Pseudomonas aeruginosa lectin LecA inhibitor by using bivalent galactosides supported on polyproline peptide scaffolds  Academic Article
• Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors  Academic Article
• Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties  Academic Article
• Development of new enzymatic catalysts for peptide-synthesis in aqueous and organic-solvents  Academic Article
• Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: Defining the binding mode of 7-oxabicyclo 2.2.1 hept-5-ene scaffold core ligands  Academic Article
• Development of sulfonamide photoaffinity inhibitors for probing cellular γ-secretase  Academic Article
• Development of thioquinazolinones, allosteric Chk1 kinase inhibitors  Academic Article
• Development of zinc finger domains for recognition of the 5 '-ann-3 ' family of DNA sequences and their use in the construction of artificial transcription factors  Academic Article
• Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies  Academic Article
• Developmentally regulated proteins of plasma-membrane of dictyostelium-discoideum - carbohydrate-binding protein  Academic Article
• Dextran as a generally applicable multivalent scaffold for improving immunoglobulin-binding affinities of peptide and peptidomimetic ligands  Academic Article
• Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes  Academic Article
• Differential and antagonistic effects of v-jun and c-jun  Academic Article
• Differential infection of receptor-modified host-cells by receptor-specific influenza-viruses  Academic Article
• Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis  Academic Article
• Difficulties in determining accurate molecular-motion parameters from proton relaxation enhancement measurements as illustrated by immunoglobulin-g . Gd(iii) system  Academic Article
• Dimerization of the klenow fragment of escherichia coli DNA polymerase i is linked to its mode of DNA binding  Academic Article
• Direct association between the yeast rad51 and rad54 recombination proteins  Academic Article
• Direct evidence for manganese(iii) binding to manganosuperoxide dismutase of escherichia-coli-b  Academic Article
• Direct measurement of the aspartic acid 26 pK(a) for reduced Escherichia coli thioredoxin by (13)C NMR  Academic Article
• Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance  Academic Article
• Direct regulation of clock expression by rev-erb  Academic Article
• Directed evolution of a bright near-infrared fluorescent rhodopsin using a synthetic chromophore  Academic Article
• Directed evolution of d-sialic acid aldolase to l-3-deoxy-manno-2-octulosonic acid (l-kdo) aldolase  Academic Article
• Directed evolution of the TALE N-terminal domain for recognition of all 5' bases  Academic Article
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• Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II)  Academic Article
• Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)  Academic Article
• Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors  Academic Article
• Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering  Academic Article
• Discovery of a small molecule insulin mimetic with antidiabetic activity in mice  Academic Article
• Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library  Academic Article
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• Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design  Academic Article
• Discovery of potent and bioavailable GSK-3β inhibitors  Academic Article
• Discovery of potent and selective covalent inhibitors of JNK  Academic Article
• Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists  Academic Article
• Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor's potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations  Academic Article
• Discovery of protein phosphatase 2C inhibitors by virtual screening  Academic Article
• Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase i7l using homology modeling and covalent docking approaches  Academic Article
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• Discrimination between steady-state kinetic models of the mechanism of action of yeast glyoxalase I  Academic Article
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• Disorder-to-order transition of the active site of human class Pi glutathione transferase, GST P1-1  Academic Article
• Dispensable pieces of an aminoacyl tRNA synthetase which activate the catalytic site  Academic Article
• Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F  Academic Article
• Dissecting the neutralizing antibody-specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors  Academic Article
• Dissection of a class II tRNA synthetase: determinants for minihelix recognition are tightly associated with domain for amino acid activation  Academic Article
• Dissection of an antibody-catalyzed reaction  Academic Article
• Dissociation of clathrin coats coupled to the hydrolysis of atp - role of an uncoating atpase  Academic Article
• Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs  Academic Article
• Distamycin and penta-N-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving  Academic Article
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• Distinct domains of tRNA synthetase recognize the same base pair  Academic Article
• Distinct structural attributes regulating von Willebrand factor A1 domain interaction with platelet glycoprotein Ib alpha under flow  Academic Article
• Distinguishing binders from false positives by free energy calculations: fragment screening against the flap site of HIV protease  Academic Article
• Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes  Academic Article
• Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin  Academic Article
• Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors  Academic Article
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• Do active site conformations of small ligands correspond to low free-energy solution structures?  Academic Article
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• Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc)  Academic Article
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• Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase  Academic Article
• Dual conformations for the hiv-1 gp120 v3 loop in complexes with different neutralizing fabs  Academic Article
• Dynamic structure of retinylidene ligand of rhodopsin probed by molecular simulations  Academic Article
• Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase  Academic Article
• Dynamic visualization of transcription and RNA subcellular localization in zebrafish  Academic Article
• Dynamics of lysozyme-saccharide interactions  Academic Article
• Dynamics of the dihydrofolate-reductase folate complex - catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features  Academic Article
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• Errors from selective disruption of the editing center in a tRNA synthetase  Academic Article
• Escherichia coli leader peptidase: production of an active form lacking a requirement for detergent and development of peptide substrates  Academic Article
• Escherichia coli ribosomes bind to non-initiator sites of Qβ RNA in the absence of formylmethionyl transfer RNA  Academic Article
• Escherichia coli signal peptide peptidase A is a serine-lysine protease with a lysine recruited to the nonconserved amino-terminal domain in the S49 protease family  Academic Article
• Escherichia-coli aspartate carbamoyltransferase - the probing of crystal-structure analysis via site-specific mutagenesis  Academic Article
• Essential arginine residues in the pyridine nucleotide binding sites of glutathione reductase  Academic Article
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• Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants  Academic Article
• Evaluating the potential for halogen bonding in the oxyanion hole of ketosteroid isomerase using unnatural amino acid mutagenesis  Academic Article
• Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies  Academic Article
• Evaluation of c3 receptors on lymphoid cells with different complement sources  Academic Article
• Evaluation of functional analogs of CC-1065 and the duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e (C2BI) alkylation subunit  Academic Article
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• Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli  Academic Article
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• Evidence for breaking domain-domain functional communication in a synthetase-tRNA complex  Academic Article
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• Evidence for distinct locations for metal binding sites in two closely related class I tRNA synthetases  Academic Article
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• Evidence for specific n-terminal galanin fragment binding-sites in the rat-brain  Academic Article
• Evidence for the binding of ng-cam to laminin  Academic Article
• Evidence from cassette mutagenesis for a structure-function motif in a protein of unknown structure  Academic Article
• Evidence that specificity of microhelix charging by a class I tRNA synthetase occurs in the transition state of catalysis  Academic Article
• Evidence that the 3' end of a tRNA binds to a site in the adenylate synthesis domain of an aminoacyl-tRNA synthetase  Academic Article
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• Evolution of glutathione transferases and related enzymes for the protection of cells against electrophiles  Academic Article
• Evolution of iron(II)-finger peptides by using a bipyridyl amino acid  Academic Article
• Evolutionary analysis of HIV-1 protease inhibitors: methods for design of inhibitors that evade resistance  Academic Article
• Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein  Academic Article
• Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme  Academic Article
• Examination of the transcription factor NtcA-binding motif by in vitro selection of DNA sequences from a random library  Academic Article
• Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase  Academic Article
• Exon 5 encoded domain is not required for the toxic function of mutant sod1 but essential for the dismutase activity: Identification and characterization of two new sod1 mutations associated with familial amyotrophic lateral sclerosis  Academic Article
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• Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors  Academic Article
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• Extent of protein-protein interactions and quasi-equivalence in viral capsids  Academic Article
• External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification  Academic Article
• Extraordinarily slow binding of guanosine to the Tetrahymena group I ribozyme: Implications for RNA preorganization and function  Academic Article
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• Factor Va residues 311-325 represent an activated protein C binding region  Academic Article
• Factor XI interacts with the leucine-rich repeats of glycoprotein Ib alpha on the activated platelet  Academic Article
• Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling  Academic Article
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• Fibronectin type III domains engineered to bind CD40L: cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of two complexes  Academic Article
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• Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120  Academic Article
• Fine tuning a molecular motor: The location of alternative domains in the drosophila myosin head  Academic Article
• Flavin adenine dinucleotide chromophore charge controls the conformation of cyclobutane pyrimidine dimer photolyase alpha-helices  Academic Article
• Flavonol activation defines an unanticipated ligand-binding site in the kinase-rnase domain of ire1  Academic Article
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• Flipping of alkylated DNA damage bridges base and nucleotide excision repair  Academic Article
• Fluorescence and nuclear relaxation enhancement studies of the binding of glutathione derivatives to manganese-reconstituted glyoxalase I from human erythrocytes. A model for the catalytic mechanism of the enzyme involving a hydrated metal ion  Academic Article
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• Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing  Academic Article
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• FoldGPCR: Structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A  Academic Article
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• Formation of two classes of tRNA synthetases in relation to editing functions and genetic code  Academic Article
• Fragment-based screen against HIV protease  Academic Article
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• Functional analysis of peptide motif for RNA microhelix binding suggests new family of RNA-binding domains  Academic Article
• Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein  Academic Article
• Functional analysis suggests unexpected role for conserved active-site residue in enzyme of known structure  Academic Article
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• Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering  Academic Article
• Functional assembly of a randomly cleaved protein  Academic Article
• Functional cavitands: Chemical reactivity in structured environments  Academic Article
• Functional cis-heterodimers of N- and R-cadherins  Academic Article
• Functional contacts of a transfer RNA synthetase with 2'-hydroxyl groups in the RNA minor groove  Academic Article
• Functional dissection of a predicted class-defining motif in a class II tRNA synthetase of unknown structure  Academic Article
• Functional dissection of circadian clock- and phytochrome-regulated transcription of the Arabidopsis CAB2 gene  Academic Article
• Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3  Academic Article
• Functional interrogation of the kinome using nucleotide acyl phosphates  Academic Article
• Functional mimicry of a protein hormone by a peptide agonist: The epo receptor complex at 2.8 Å  Academic Article
• Functional modulation of the isolated glycoprotein Ib binding domain of von Willebrand factor expressed in Escherichia coli  Academic Article
• Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes  Academic Article
• Functional redundancy in the nonspecific RNA binding domain of a class I tRNA synthetase  Academic Article
• Functional role for a conserved aspartate in the spo0e signature motif involved in the dephosphorylation of the bacillus subtilis sporulation regulator spo0a  Academic Article
• Functional roles for the striatal-enriched transcription factor, bcl11b, in the control of striatal gene expression and transcriptional dysregulation in huntington's disease  Academic Article
• Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1.  Academic Article
• Functional studies and homology modeling of Msh2-Msh3 predict that mispair recognition involves DNA bending and strand separation  Academic Article
• Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface  Academic Article
• Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein e2c direct integration of viral DNA into specific sites  Academic Article
• GIGANTEA directly activates Flowering Locus T in Arabidopsis thaliana  Academic Article
• GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex  Academic Article
• GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function  Academic Article
• Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B  Academic Article
• Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors  Academic Article
• Gating mechanisms of acid-sensing ion channels  Academic Article
• Gene transcription through activation of G-protein-coupled chemoattractant receptors  Academic Article
• Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration  Academic Article
• Generation and characterization of specific antibodies directed to the binding domain of adhesive molecules  Academic Article
• Generation of a Ni(II) binding site by introduction of a histidine cluster in the structure of human glutathione transferase A1-1  Academic Article
• Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe  Academic Article
• Genetic introduction of a diketone-containing amino acid into proteins  Academic Article
• Genetic selection of short peptides that support protein oligomerization in vivo  Academic Article
• Genetically encoded fragment-based discovery of glycopeptide ligands for carbohydrate-binding proteins  Academic Article
• Genome-wide analysis of CREB target genes reveals a core promoter requirement for camp responsiveness  Academic Article
• Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues  Academic Article
• Genome-wide analysis reveals padi4 cooperates with elk-1 to activate c-fos expression in breast cancer cells  Academic Article
• Genome-wide identification of bcl11b gene targets reveals role in brain-derived neurotrophic factor signaling  Academic Article
• Genome-wide nucleosome mapping of plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes  Academic Article
• Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma  Academic Article
• Genomic effects of polyamide/DNA interactions on mRNA expression  Academic Article
• Genomic-scale comparison of sequence- and structure-based methods of function prediction: Does structure provide additional insight?  Academic Article
• Global structural changes in hepatitis b virus capsids induced by the assembly effector hap1  Academic Article
• Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles  Academic Article
• Glutathione transferases in the bioactivation of azathioprine  Academic Article
• Glutathione transferases with novel active sites isolated by phage display from a library of random mutants  Academic Article
• Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2  Academic Article
• Glycoproteins of plasma-membrane of dictyostelium discoideum during development  Academic Article
• Glycosaparaginase from human leukocytes. Inactivation and covalent modification with diazo-oxonorvaline  Academic Article
• Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin  Academic Article
• Gp120: Biologic aspects of structural features  Academic Article
• Gpcr agonist binding revealed by modeling and crystallography  Academic Article
• Growth hormone releasing substances: types and their receptors  Academic Article
• H-1 NMR-studies at 360 mhz of aromatic amino-acid residues in ferrocytochrome c-552 from euglena-gracilis  Academic Article
• H-1 NMR-studies at 360 mhz of methyl-groups in native and chemically modified basic pancreatic trypsin-inhibitor (bpti)  Academic Article
• H-1 NMR-studies of heme iron coordination in cytochrome c-552 from euglena-gracilis  Academic Article
• H-1, n-15 and c-13 resonance assignments, secondary structure, and the conformation of substrate in the binary folate complex of escherichia-coli dihydrofolate-reductase  Academic Article
• H-1, n-15, and c-13 backbone chemical-shift assignments, secondary structure, and magnesium-binding characteristics of the bacillus-subtilis response regulator, spoof, determined by heteronuclear high-resolution NMR  Academic Article
• H-1-NMR studies of the coordination geometry at the heme iron and the electronic-structure of the heme group in cytochrome-c-552 from euglena-gracilis  Academic Article
• HCV NS5A and IRF9 compete for CypA binding  Academic Article
• HCV core residues critical for infectivity are also involved in core-NS5A complex formation  Academic Article
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• HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites  Academic Article
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• Helix 11 dynamics is critical for constitutive androstane receptor activity  Academic Article
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• Hepatocyte nuclear factor-4-independent synthesis of coagulation factor vii in breast cancer cells and its inhibition by targeting selective histone acetyltransferases  Academic Article
• Heterocyclic derivatives of 2-(3,5-dimethylphenyl)tryptamine as GnRH receptor antagonists  Academic Article
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• Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs  Academic Article
• Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation  Academic Article
• Importance of minor groove binding zinc fingers within the transcription factor IIIA-DNA complex  Academic Article
• Importin beta contains a cooh-terminal nucleoporin binding region important for nuclear transport  Academic Article
• Improved design of an antigen with enhanced specificity for the broadly hiv-neutralizing antibody b12  Academic Article
• Improved identification of SUMO attachment sites using C-terminal SUMO mutants and tailored protease digestion strategies  Academic Article
• Improved model building and assessment of the Calcium-sensing receptor transmembrane domain  Academic Article
• Improving the serum stability of site-specific antibody conjugates with sulfone linkers  Academic Article
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• In silico screening against wild-type and mutant Plasmodium falciparum dihydrofolate reductase  Academic Article
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• In vitro analysis of nuclear transport mediated by the c-terminal shuttle domain of tap  Academic Article
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• In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase  Academic Article
• In vivo, in vitro, and molecular aspects of interleukin-8 and the interleukin-8 receptors  Academic Article
• In-line separation by capillary electrophoresis prior to analysis by top-down mass spectrometry enables sensitive characterization of protein complexes  Academic Article
• In-vitro evolution of a neutralizing human-antibody to human-immunodeficiency-virus type-1 to enhance affinity and broaden strain cross-reactivity  Academic Article
• Inactivation of beta-adrenergic receptors by n-ethylmaleimide - permissive role of beta-adrenergic agents in relation to adenylate-cyclase activation  Academic Article
• Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A  Academic Article
• Increasing protein stability using a rational approach combining sequence homology and structural alignment: stabilizing the WW domain  Academic Article
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• Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody  Academic Article
• Individual h-1-NMR assignments for the heme groups and the axially bound amino-acids and determination of the coordination geometry at the heme iron in a mixture of 2 isocytochromes-c-551 from rhodopseudomonas-gelatinosa  Academic Article
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• Influence of novel cd4 binding-defective hiv-1 envelope glycoprotein immunogens on neutralizing antibody and t-cell responses in nonhuman primates  Academic Article
• Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein  Academic Article
• Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity  Academic Article
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• Inhibiting transthyretin amyloid fibril formation via protein stabilization  Academic Article
• Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors  Academic Article
• Inhibition by capsaicin of nadh-quinone oxidoreductases is correlated with the presence of energy-coupling site-1 in various organisms  Academic Article
• Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-kappa B, and DNA by a designed DNA-binding ligand  Academic Article
• Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes  Academic Article
• Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands  Academic Article
• Inhibition of a viral enzyme by a small-molecule dimer disruptor  Academic Article
• Inhibition of cytochrome p-450 activity in rat liver microsomes by the naturally occurring flavonoid, quercetin  Academic Article
• Inhibition of glutathione reductase by interaction of 2, 4, 6-trinitrobenzenesulfonate with the active-site dithiol  Academic Article
• Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site  Academic Article
• Inhibition of proteolysis and other posttranslational modifications with substrate-targeted inhibitors  Academic Article
• Inhibitor focusing: direct selection of drug targets from proteomes using activity-based probes  Academic Article
• Inscribing the perimeter of the PagP hydrocarbon ruler by site-specific chemical alkylation  Academic Article
• Insertion of new sequences into the catalytic domain of an enzyme  Academic Article
• Insight into the sporulation phosphorelay: Crystal structure of the sensor domain of Bacillus subtilis histidine kinase, KinD  Academic Article
• Insights into PPAR gamma from structures with endogenous and covalently bound ligands  Academic Article
• Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9 Å resolution  Academic Article
• Insights into the mode of action of a putative zinc transporter czrb in thermus thermophilus  Academic Article
• Insights into the nature of DNA binding of AbrB-like transcription factors  Academic Article
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• Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage  Academic Article
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• Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function  Academic Article
• Interaction of DNA with the klenow fragment of DNA-polymerase-i studied by time-resolved fluorescence spectroscopy  Academic Article
• Interaction of Lp(a) with plasminogen binding sites on cells  Academic Article
• Interaction of colchicine and some related alkaloids with rat-brain tubulin  Academic Article
• Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II  Academic Article
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• Interaction of human hemoglobin with adenine nucleotides  Academic Article
• Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites  Academic Article
• Interaction of lysozyme with alpha-N-acetyl-D-glucosamine  Academic Article
• Interaction of manganese with fragments, complementary fragment recombinations, and whole molecules of yeast phenylalanine specific transfer RNA  Academic Article
• Interaction of polyamines with fragments and whole molecules of yeast phenylalanine-specific transfer RNA  Academic Article
• Interaction of the RNA-binding fingers of Xenopus transcription factor IIIA with specific regions of 5-S ribosomal-RNA  Academic Article
• Interaction of the mediator head module with RNA polymerase II  Academic Article
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• Interactions of Qβ replicase with Qβ RNA  Academic Article
• Interactions of active-site residues and catalytic activity of human carbonic anhydrase III  Academic Article
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• Interactions of soluble recombinant integrin alpha v beta 5 with human adenoviruses  Academic Article
• Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression  Academic Article
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• Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters  Academic Article
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• Involvement of an active-site Zn2+ ligand mechanism of human glyoxalase I  Academic Article
• Iron superoxide-dismutase from escherichia-coli at 3.1-a resolution - a structure unlike that of copper-zinc protein at both monomer and dimer levels  Academic Article
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• Isoform-selective and stereoselective inhibition of hypoxia inducible factor-2  Academic Article
• Isolated RNA binding domain of a class I tRNA synthetase  Academic Article
• Isolation and characterization of a collagen binding domain in human von Willebrand factor  Academic Article
• Isolation and characterization of maclura pomifera (mp) lectin  Academic Article
• Isolation and characterization of the DNA and protein binding activities of adenovirus core protein V  Academic Article
• Isolation and functional characterization of the von Willebrand factor-binding domain located between residues His1-Arg293 of the alpha-chain of glycoprotein Ib  Academic Article
• Isolation and sequence-specific DNA-binding of the antennapedia homeodomain  Academic Article
• Isolation of lectins of different specificities on a single affinity adsorbent  Academic Article
• Isolation of the von Willebrand factor domain interacting with platelet glycoprotein Ib, heparin, and collagen and characterization of its three distinct functional sites  Academic Article
• Isothermal titration calorimetry and surface plasmon resonance allow quantifying substrate binding to different binding sites of Bacillus subtilis xylanase  Academic Article
• Isotope labeling of free and aminoacyl transfer RNA synthetase-bound transfer RNA  Academic Article
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• Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein tpr  Academic Article
• Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP  Academic Article
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• Kinetic analysis of the interaction between type 1 plasminogen activator inhibitor and vitronectin and evidence that the bovine inhibitor binds to a thrombin-derived amino-terminal fragment of bovine vitronectin  Academic Article
• Kinetic analysis of the interaction between vitronectin and the urokinase receptor  Academic Article
• Kinetic and spectroscopic evidence for three actomyosin : Adp states in smooth muscle  Academic Article
• Kinetic and stoichiometric characterisation of streptavidin-binding aptamers  Academic Article
• Kinetic independence of the subunits of cytosolic glutathione transferase from the rat  Academic Article
• Kinetic intermediates trapped by native interactions in RNA folding  Academic Article
• Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3 alpha 1  Academic Article
• Kinetic mechanism of RGS9-1 potentiation by R9AP  Academic Article
• Kinetics and mechanisms of reduction of cu(ii) and fe(iii) complexes by soybean leghemoglobin-alpha  Academic Article
• Kinetics and mechanisms of the oxidation of myoglobin by fe(iii) and cu(ii) complexes  Academic Article
• Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of udp-glcnac enolpyruvoyl transferase by the antibiotic fosfomycin  Academic Article
• Kinomics-structural biology and chemogenomics of kinase inhibitors and targets  Academic Article
• Kinomics: Characterizing the therapeutically validated kinase space  Academic Article
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• Lack of complex i activity in human cells carrying a mutation in mtdna-encoded nd4 subunit is corrected by the saccharomyces cerevisiae nadh-quinone oxidoreductase (ndi1) gene  Academic Article
• Lactose binding induces opposing dynamics changes in human galectins revealed by NMR-based hydrogen-deuterium exchange  Academic Article
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• Leu628 of the kix domain of cbp is a key residue for the interaction with the mll transactivation domain  Academic Article
• Ligand accessibility to the HIV-1 Env co-receptor binding site can occur prior to CD4 engagement and is independent of viral tier category  Academic Article
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• Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues  Academic Article
• Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening  Academic Article
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• Ligand-guided receptor optimization  Academic Article
• Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor  Academic Article
• Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation  Academic Article
• Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms  Academic Article
• Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate  Academic Article
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• Lipid binding promotes oligomerization and focal adhesion activity of vinculin  Academic Article
• Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells - regulation by egr-1, c-jun, and nf-kappa b transcription factors  Academic Article
• Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2  Academic Article
• Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in thp-1 monocytic cells requires both activator protein-1 and nuclear factor-kappa-b binding-sites  Academic Article
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• Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity  Academic Article
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• Location, degree, and direction of DNA bending associated with the Hin recombinational enhancer sequence and Fis-enhancer complex  Academic Article
• Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase  Academic Article
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• Mapping a common interaction site used by plasmodium falciparum duffy binding-like domains to bind diverse host receptors  Academic Article
• Mapping binding residues in the Plasmodium vivax domain that binds Duffy antigen during red cell invasion  Academic Article
• Mapping determinants of the substrate selectivities of P450 enzymes by site-directed mutagenesis  Academic Article
• Mapping enzyme active sites in complex proteomes  Academic Article
• Mapping interactions between the rna chaperone fino and its rna targets  Academic Article
• Mapping of distinct von Willebrand factor domains interacting with platelet GPIb and GPIIb/IIIa and with collagen using monoclonal antibodies  Academic Article
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• Mapping of the cxcr4 binding site within variable region 3 of the feline immunodeficiency virus surface glycoprotein  Academic Article
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• Mapping the interactions of the p53 transactivation domain with the kix domain of cbp  Academic Article
• Mapping the transition state of the WW domain beta-sheet  Academic Article
• Measles virus recognizes its receptor, cd46, via two distinct binding domains within scr1-2  Academic Article
• Measles-virus and c3 binding-sites are distinct on membrane cofactor protein (cd46)  Academic Article
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• Mechanism of Action of an Imidopiperidine Inhibitor of Human Polynucleotide Kinase/Phosphatase  Academic Article
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• Minor groove recognition of the critical acceptor helix base pair by an appended module of a class II tRNA synthetase  Academic Article
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• Molecular basis for p38 protein kinase inhibitor specificity  Academic Article
• Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity  Academic Article
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• Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta  Academic Article
• Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition  Academic Article
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• Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions  Academic Article
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• Molecular cloning of Limulus alpha 2-macroglobulin  Academic Article
• Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P  Academic Article
• Molecular determinants of lxr alpha agonism  Academic Article
• Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3  Academic Article
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• Molecular editing of kinase-targeting resorcylic acid lactones (RAL): Fluoroenone RAL  Academic Article
• Molecular evolution of antibody cross-reactivity for two subtypes of type a botulinum neurotoxin  Academic Article
• Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120  Academic Article
• Molecular mechanism for the umami taste synergism  Academic Article
• Molecular mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia - roles of conserved active site residues  Academic Article
• Molecular mechanism of the sweet taste enhancers  Academic Article
• Molecular modeling and crystal structure of ERK2-hypothemycin complexes  Academic Article
• Molecular probes of spermatozoan structures  Academic Article
• Molecular recognition and binding free energy calculations in drug development  Academic Article
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• Molecular recognition of insulin by a synthetic receptor  Academic Article
• Molecular recognition: model studies with convergent functional groups  Academic Article
• Molecular-cloning of the cdna-encoding the epstein-barr virus/c3d receptor (complement receptor type-2) of human lymphocytes-b  Academic Article
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• Monovalet derivatives of concanavalin-a  Academic Article
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• Multiple sites on IL-8 responsible for binding to alpha and beta IL-8 receptors  Academic Article
• Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1  Academic Article
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• Muscarinic acetylcholine receptor from rat brain. Partial purification and characterization  Academic Article
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• Mutagenesis study on human galanin receptor GalR1 reveals domains involved in ligand binding  Academic Article
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• Role of DNA sequence in the binding specificity of synthetic basic-helix-loop-helix domains  Academic Article
• Role of RNA structure in arginine recognition of TAR RNA  Academic Article
• Role of Rab9 GTPase in facilitating receptor recruitment by TIP47  Academic Article
• Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome  Academic Article
• Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase  Academic Article
• Role of an active site adenine in hairpin ribozyme catalysis  Academic Article
• Role of an active site guanine in hairpin ribozyme catalysis probed by exogenous nucleobase rescue  Academic Article
• Role of aspartate-37 in determining cofactor specificity and binding in rat-liver dihydropteridine reductase  Academic Article
• Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization  Academic Article
• Role of cyclic nucleotides in central synaptic function  Academic Article
• Role of electrostatic interactions in PDZ domain ligand recognition  Academic Article
• Role of gtp hydrolysis in microtubule dynamics - information from a slowly hydrolyzable analog, gmpcpp  Academic Article
• Role of hydrogen bonding in the active site of human manganese superoxide dismutase  Academic Article
• Role of the glutamyl alpha-carboxylate of the substrate glutathione in the catalytic mechanism of human glutathione transferase A1-1  Academic Article
• Role of third intracellular loop of galanin receptor type 1 in signal transduction  Academic Article
• Role of tryptophan 161 in catalysis by human manganese superoxide dismutase  Academic Article
• Role of zymogen and activated factor x as scaffolds for the inhibition of the blood coagulation factor viia-tissue factor complex by recombinant nematode anticoagulant protein c2  Academic Article
• Roles of Dim2 in ribosome assembly  Academic Article
• Roles of IFN consensus sequence binding protein and PU.1 in regulating IL-18 gene expression  Academic Article
• Roles of bound quinone in the single subunit nadh-quinone oxidoreductase (ndi1) from saccharomyces cerevisiae  Academic Article
• Rotational correlation time of concanavalin-a after interaction with a fluorescent-probe  Academic Article
• Routes to catalysis - structure of a catalytic antibody and comparison with its natural counterpart  Academic Article
• Rrna-complementarity in the 5 ' untranslated region of mrna specifying the gtx homeodomain protein: Evidence that base-pairing to 18s rrna affects translational efficiency  Academic Article
• S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration  Academic Article
• S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death  Academic Article
• S1p(1)-selective in vivo-active agonists from high-throughput screening: Off-the-shelf chemical probes of receptor interactions, signaling, and fate  Academic Article
• SDOCKER: A method utilizing existing X-ray structures to improve docking accuracy  Academic Article
• SIR1, an upstream component in auxin signaling identified by chemical genetics  Academic Article
• SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation  Academic Article
• SR2067 reveals a unique kinetic and structural signature for PPARγ partial agonism  Academic Article
• SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent  Academic Article
• STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells  Academic Article
• SUMO-binding motifs mediate the Rad60-dependent response to replicative stress and self-association  Academic Article
• SV40 T antigen interacts with Nbs1 to disrupt DNA replication control  Academic Article
• Saccharomyces cerevisiae lme2 phosphorylates Sic1 at multiple PXS/T sites but is insufficient to trigger Sic1 degradation  Academic Article
• Salicylates are interference compounds in TR-FRET assays  Academic Article
• Screening a peptidyl database for potential ligands to proteins with side-chain flexibility  Academic Article
• Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay  Academic Article
• Screening transthyretin amyloid fibril inhibitors: Characterization of novel multiprotein, multiligand complexes by mass spectrometry  Academic Article
• Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2  Academic Article
• Selecting against s1p(3) enhances the acute cardiovascular tolerability of 3-(n-benzyl)aminopropylphosphonic acid s1p receptor agonists  Academic Article
• Selection and application of peptide-binding peptides  Academic Article
• Selection by site-directed antibodies of small regions of peptides which are ordered in water  Academic Article
• Selection of apoptotic cell specific human antibodies from adult bone marrow  Academic Article
• Selection pressure on hiv-1 envelope by broadly neutralizing antibodies to the conserved cd4-binding site  Academic Article
• Selective attenuation of the extrinsic limb of the tissue factor-driven coagulation protease cascade by occupancy of a novel peptidyl docking site on tissue factor  Academic Article
• Selective binding-site for (prostacyclin-h-3 on platelets  Academic Article
• Selective chemical catalysis by an antibody  Academic Article
• Selective inhibition of ADAR2-catalyzed editing of the serotonin 2c receptor pre-mRNA by a helix-threading peptide  Academic Article
• Selective interaction of heparin with the variable region 3 within surface glycoprotein of laboratory-adapted feline immunodeficiency virus  Academic Article
• Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120  Academic Article
• Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets  Academic Article
• Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for analysis of peptide hormone interactions with bovine neurophysin i using 13C nuclear magnetic-resonance spectroscopy  Academic Article
• Selectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuations  Academic Article
• Self-association of the histidine kinase CheA as studied by pulsed dipolar ESR spectroscopy  Academic Article
• Sendai virus utilizes specific sialyloligosaccharides as host-cell receptor determinants  Academic Article
• Sensitizer-linked substrates and ligands: Ruthenium probes of cytochrome P450 structure and mechanism  Academic Article
• Separate cell-binding sites within cytotactin tenascin differentially promote neurite outgrowth  Academic Article
• Sequence and structural convergence of broad and potent hiv antibodies that mimic cd4 binding  Academic Article
• Sequence homology and structural analysis of the clostridial neurotoxins  Academic Article
• Sequence, structure and energetic determinants of phosphopeptide selectivity of SH2 domains  Academic Article
• Sequence-specific NMR assignment of proteins by global fragment mapping with the program mapper  Academic Article
• Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides  Academic Article
• Sequence-specific resonance assignments in the h-1-NMR spectrum of the lac repressor DNA-binding domain 1-51 from escherichia-coli by two-dimensional spectroscopy  Academic Article
• Sequential action of MalE and maltose allows coupling ATP hydrolysis to translocation in the MalFGK(2) transporter  Academic Article
• Ser-884 adjacent to the lxxll motif of coactivator trbp defines selectivity for ers and trs  Academic Article
• Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations  Academic Article
• Serine hydrolase KIAA1363: Toxicological and structural features with emphasis on organophosphate interactions  Academic Article
• Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport  Academic Article
• Seven clues to the origin and structure of class-I ribonucleotide reductase intermediate X  Academic Article
• Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme  Academic Article
• Shape complementarity of protein-protein complexes at multiple resolutions  Academic Article
• Shape-specific nucleotide binding of single-stranded RNA by the GLD-1 STAR domain  Academic Article
• Shigella applies molecular mimicry to subvert vinculin and invade host cells  Academic Article
• Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines  Academic Article
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• Side-chain conformational heterogeneity of intermediates in the Escherichia coli dihydrofolate reductase catalytic cycle  Academic Article
• Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells  Academic Article
• Significant structural and functional change of an antigen-binding site by a distant amino-acid substitution - proposal of a structural mechanism  Academic Article
• Simple method for production of specific xenoantisera to human histocompatibility (hla-a, hla-b, hla-c) antigens  Academic Article
• Simple reporter gene-based assays for hairpin poly(amide) conjugate permeability and DNA-binding activity in living cells  Academic Article
• Simultaneous binding of two proteins to opposite sides of a single transfer RNA  Academic Article
• Single sequence of a helix-loop peptide confers functional anticodon recognition on two tRNA synthetases  Academic Article
• Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR  Academic Article
• Single-step inline hydroxyapatite enrichment facilitates identification and quantitation of phosphopeptides from mass-limited proteomes with MudPIT  Academic Article
• Site-directed mutagenesis of the complement c5a receptor - examination of a model for its interaction with the ligand c5a  Academic Article
• Site-directed mutagenesis of the human beta(3)-adrenoceptor - transmembrane residues involved in ligand binding and signal transduction  Academic Article
• Site-selective cleavage of structured RNA by a Staphylococcal nuclease DNA hybrid  Academic Article
• Site-specific glycoconjugation of protein via bioorthogonal tetrazine cycloaddition with a genetically encoded trans-cyclooctene or bicyclononyne  Academic Article
• Site-specific immobilization of enzymes on magnetic nanoparticles and their use in organic synthesis  Academic Article
• Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept  Academic Article
• Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intron  Academic Article
• Small molecule modulation of nuclear receptor conformational dynamics: implications for function and drug discovery  Academic Article
• Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport  Academic Article
• Small terminase couples viral DNA binding to genome-packaging ATPase activity  Academic Article
• Small-molecule binding to an artificially created cavity at the active-site of cytochrome-c peroxidase  Academic Article
• Small-molecule effectors of hepatitis b virus capsid assembly give insight into virus life cycle  Academic Article
• Small-molecule inhibitors of the c-Fes protein-tyrosine kinase  Academic Article
• Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity  Academic Article
• Sodium ion binding pocket mutations and adenosine A2A receptor function  Academic Article
• Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain  Academic Article
• Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing  Academic Article
• Solution structure of Escherichia coli glutaredoxin-2 shows similarity to mammalian glutathione-S-transferases  Academic Article
• Solution structure of rnase p rna  Academic Article
• Solution structure of sperm lysin yields novel insights into molecular dynamics of rapid protein evolution  Academic Article
• Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions  Academic Article
• Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP  Academic Article
• Solution structure of the cysteine-rich domain of the Escherichia coli chaperone protein DnaJ  Academic Article
• Solution structure of the kix domain of cbp bound to the transactivation domain of c-myb  Academic Article
• Solution structure of the third immunoglobulin domain of the neural cell adhesion molecule N-CAM: can solution studies define the mechanism of homophilic binding?  Academic Article
• Some new views of the cell surface  Academic Article
• Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization  Academic Article
• Spatially directed assembly of a heterotetrameric Cre-Lox synapse restricts recombination specificity  Academic Article
• Species barrier to RNA recognition overcome with nonspecific RNA binding domains  Academic Article
• Species-specific tRNA recognition in relation to tRNA synthetase contact residues  Academic Article
• Specific binding of RGS9-G beta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity  Academic Article
• Specific fractionation of immune cell populations  Academic Article
• Specific killing of hiv-infected lymphocytes by a recombinant immunotoxin directed against the hiv-1 envelope glycoprotein  Academic Article
• Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide  Academic Article
• Spectroscopic characterization of the heme-binding sites in plasmodium falciparum histidine-rich protein 2  Academic Article
• Spectroscopic studies of the DNA-binding site of the gal4 zinc finger protein  Academic Article
• Sphingolipids as bioactive regulators of thrombin generation  Academic Article
• Spontaneous platelet aggregation in type IIB Tampa von Willebrand disease is inhibited by the 52/48-kDa fragment of normal von Willebrand factor, which contains the GPIb binding domain  Academic Article
• Stability of hairpin ribozyme tertiary structure is governed by the interdomain junction  Academic Article
• Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function  Academic Article
• Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3cl protease  Academic Article
• Starving the malaria parasite: Inhibitors active against the aspartic proteases plasmepsins I, II, and IV  Academic Article
• Statistical positioning of nucleosomes by specific protein-binding to an upstream activating sequence in yeast  Academic Article
• Status of gpcr modeling and docking as reflected by community-wide gpcr dock 2010 assessment  Academic Article
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• Stimulation of nuclear export and inhibition of nuclear import by a ran mutant deficient in binding to ran-binding protein 1  Academic Article
• Strained cyclic disulfides enable cellular uptake by reacting with the transferrin receptor  Academic Article
• Streptococcal m1 protein constructs a pathological host fibrinogen network  Academic Article
• Striated muscle activator of Rho signalling (STARS) is a PGC-1 alpha/oestrogen-related receptor-alpha target gene and is upregulated in human skeletal muscle after endurance exercise  Academic Article
• Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling  Academic Article
• Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains  Academic Article
• Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1  Academic Article
• Structural analysis of caspase-1 inhibitors derived from Tethering  Academic Article
• Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate  Academic Article
• Structural analysis of inhibitor binding to human carbonic anhydrase II  Academic Article
• Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity  Academic Article
• Structural analysis of papain-like NlpC/p60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites  Academic Article
• Structural and biochemical characterization of the therapeutic anabaena variabilis phenylalanine ammonia lyase  Academic Article
• Structural and biophysical characterization of the EphB4.ephrinB2 protein-protein interaction and receptor specificity  Academic Article
• Structural and functional analysis of the plasminogen activator inhibitor-1 binding motif in the somatomedin B domain of vitronectin  Academic Article
• Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes  Academic Article
• Structural and functional studies of the measles virus hemagglutinin: Identification of a novel site required for cd46 interaction  Academic Article
• Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II  Academic Article
• Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6  Academic Article
• Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome p4502b4  Academic Article
• Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles  Academic Article
• Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair  Academic Article
• Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors  Academic Article
• Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor  Academic Article
• Structural basis for amplifying vinculin activation by talin  Academic Article
• Structural basis for bifunctional peptide recognition at human delta-opioid receptor  Academic Article
• Structural basis for chloramphenicol tolerance in Streptomyces venezuelae by chloramphenicol phosphotransferase activity  Academic Article
• Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases  Academic Article
• Structural basis for endothelial nitric oxide synthase binding to calmodulin  Academic Article
• Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase  Academic Article
• Structural basis for hif-1 alpha/cbp recognition in the cellular hypoxic response  Academic Article
• Structural basis for high-affinity peptide inhibition of human Pin1  Academic Article
• Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics  Academic Article
• Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase  Academic Article
• Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway  Academic Article
• Structural basis for molecular recognition at serotonin receptors  Academic Article
• Structural basis for recognition and catalysis by the bifunctional dctp deaminase and dutpase from methanococcus jannaschii  Academic Article
• Structural basis for recruitment of cbp/p300 coactivators by stat1 and stat2 transactivation domains  Academic Article
• Structural basis for specific inhibition of tRNA synthetase by an ATP competitive inhibitor  Academic Article
• Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase  Academic Article
• Structural basis for the coevolution of a viral RNA-protein complex  Academic Article
• Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases  Academic Article
• Structural basis for type-I and type-II deficiencies of antithrombotic plasma protein-C - patterns revealed by 3-dimensional molecular modeling of mutations of the protease domain  Academic Article
• Structural basis of IMP3 RRM12 recognition of RNA  Academic Article
• Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2  Academic Article
• Structural basis of Rho GTPase-mediated activation of the formin rndia1  Academic Article
• Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain  Academic Article
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• Structural basis of autoregulation of phenylalanine hydroxylase  Academic Article
• Structural basis of cell surface receptor recognition by botulinum neurotoxin B  Academic Article
• Structural basis of immune evasion at the site of cd4 attachment on hiv-1 gp120  Academic Article
• Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion  Academic Article
• Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R  Academic Article
• Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters  Academic Article
• Structural basis of single-nucleotide polymorphisms in cytochrome P450 2C9  Academic Article
• Structural basis of steroid hormone perception by the receptor kinase bri1  Academic Article
• Structural basis of substrate methylation and inhibition of SMYD2  Academic Article
• Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant  Academic Article
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• Structural changes that occur upon photolysis of the fe(ii)(a3)-co complex in the cytochrome ba(3)-oxidase of thermus thermophilus: A combined x-ray crystallographic and infrared spectral study demonstrates co binding to cu-b  Academic Article
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• Structural characterization of a p-acetylphenylalanyl aminoacyl-tRNA synthetase  Academic Article
• Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism  Academic Article
• Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica  Academic Article
• Structural characterization of enterobactin hydrolase IroE  Academic Article
• Structural characterization of the 1918 influenza virus h1n1 neuraminidase  Academic Article
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• Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS  Academic Article
• Structural definition of a conserved neutralization epitope on HIV-1 gp120  Academic Article
• Structural determinants in domain II of human glutathione transferase M2-2 govern the characteristic activities with aminochrome, 2-cyano-1,3-dimethyl-1-nitrosoguanidine, and 1,2-dichloro-4-nitrobenzene  Academic Article
• Structural determinants of binding the seven-transmembrane domain of the glucagon-like peptide-1 receptor (GLP-1R)  Academic Article
• Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members  Academic Article
• Structural determinants of rotavirus subgroup specificity mapped by cryo-electron microscopy  Academic Article
• Structural dynamics of hiv-1 rev and its complexes with rre and 5s rna  Academic Article
• Structural evidence for substrate strain in antibody catalysis  Academic Article
• Structural features for functional selectivity at serotonin receptors  Academic Article
• Structural identification of the antibody-binding sites of hong-kong influenza hemagglutinin and their involvement in antigenic variation  Academic Article
• Structural insight into pH-induced conformational changes within the native human transthyretin tetramer  Academic Article
• Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants  Academic Article
• Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor  Academic Article
• Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein  Academic Article
• Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B  Academic Article
• Structural insights into protein-metal ion partnerships  Academic Article
• Structural insights into the avian aicar transformylase mechanism  Academic Article
• Structural insights into the evolution of an antibody combining site  Academic Article
• Structural insights into the function of the rab gdi superfamily  Academic Article
• Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor  Academic Article
• Structural insights into the mechanisms of mg2+ uptake, transport, and gating by cora  Academic Article
• Structural insights into the molecular mechanism of h-nox activation  Academic Article
• Structural insights into the recognition of phosphopeptide by the FHA domain of kanadaptin  Academic Article
• Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins  Academic Article
• Structural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103  Academic Article
• Structural invariance of constitutively active and inactive mutants of acanthamoeba myosin ic bound to f-actin in the rigor and adp-bound states  Academic Article
• Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus  Academic Article
• Structural mechanism of abscisic acid binding and signaling by dimeric PYR1  Academic Article
• Structural mimicry in the phage phi 21 N peptide-boxB RNA complex  Academic Article
• Structural model studies for the peroxo intermediate P and the reaction pathway from P -> Q of methane monooxygenase using broken-symmetry density functional calculations  Academic Article
• Structural organization of complexes of transfer RNAs with aminoacyl transfer RNA synthetases  Academic Article
• Structural plasticity and the evolution of antibody affinity and specificity  Academic Article
• Structural properties of non-traditional drug targets present new challenges for virtual screening  Academic Article
• Structural representative of the protein family PF14466 has a new fold and establishes links with the C2 and PLAT domains from the widely distant Pfams PF00168 and PF01477  Academic Article
• Structural role of a buried salt bridge in the 434 repressor DNA-binding domain  Academic Article
• Structural studies of FIV and HIV-1 proteases complexed with all efficient inhibitor of FIV protease  Academic Article
• Structural studies of atom-specific anticancer drugs acting on DNA  Academic Article
• Structural studies of cytochrome c-551 by h-1 NMR-spectroscopy at 360 mhz  Academic Article
• Structural studies of p21(waf1/cip1/sdi1) in the free and cdk2-bound state: Conformational disorder mediates binding diversity  Academic Article
• Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors  Academic Article
• Structural variations in species B adenovirus fibers impact CD46 association  Academic Article
• Structural-analysis of rauscher virus gp70 using monoclonal-antibodies - sites of antigenicity and p15(e) linkage  Academic Article
• Structural-based analysis of dihydrofolate reductase evolution  Academic Article
• Structure analysis of peptide deformylases from Streptococcus pneumoniae, Staphylococcus aureus, Thermotoga maritima and Pseudomonas aeruginosa: Snapshots of the oxygen sensitivity of peptide deformylase  Academic Article
• Structure and activity of a thermostable thymine-DNA glycosylase: Evidence for base twisting to remove mismatched normal DNA bases  Academic Article
• Structure and dynamics of the liver receptor homolog 1-PGC1α complex  Academic Article
• Structure and function of a genetically engineered mimic of a nonenveloped virus entry intermediate  Academic Article
• Structure and function of a novel LD-carboxypeptidase A involved in peptidoglycan recycling  Academic Article
• Structure and function of an unusual family of protein phosphatases: the bacterial chemotaxis proteins CheC and CheX  Academic Article
• Structure and function of helix-loop-helix proteins  Academic Article
• Structure and function of phage rna  Academic Article
• Structure and function of the von Willebrand factor A1 domain  Academic Article
• Structure and function of von Willebrand factor: relationship to von Willebrand's disease  Academic Article
• Structure and functional characterization of the rna-binding element of the nlrx1 innate immune modulator  Academic Article
• Structure and functional role of dynein's microtubule-binding domain  Academic Article
• Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634  Academic Article
• Structure and lytic activity of a bacillus anthracis prophage endolysin  Academic Article
• Structure and mechanism of copper, zinc superoxide-dismutase  Academic Article
• Structure and mechanism of the ruvb holliday junction branch migration motor  Academic Article
• Structure and mutational analysis of Rab GDP-dissociation inhibitor  Academic Article
• Structure and receptor specificity of the hemagglutinin from an h5n1 influenza virus  Academic Article
• Structure and thermodynamic characterization of the ephb4/ephrin-b2 antagonist peptide complex reveals the determinants for receptor specificity  Academic Article
• Structure at 0.85 Å resolution of an early protein photocycle intermediate  Academic Article
• Structure based prediction of subtype-selectivity for adenosine receptor antagonists  Academic Article
• Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes  Academic Article
• Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 A resolution: The first structural representative of a new protein family that may play a role in carbohydrate metabolism  Academic Article
• Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding  Academic Article
• Structure of SARS coronavirus spike receptor-binding domain complexed with receptor  Academic Article
• Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase  Academic Article
• Structure of Thermotoga maritima TM0439: Implications for the mechanism of bacterial GntR transcription regulators with Zn(2+)-binding FCD domains  Academic Article
• Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion  Academic Article
• Structure of a cation-bound multidrug and toxic compound extrusion transporter  Academic Article
• Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator  Academic Article
• Structure of a dicationic monoimidazole lexitropsin bound to DNA  Academic Article
• Structure of a kinesin microtubule depolymerization machine  Academic Article
• Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site  Academic Article
• Structure of a nitric oxide synthase heme protein from Bacillus subtilis  Academic Article
• Structure of a protein photocycle intermediate by millisecond time-resolved crystallography  Academic Article
• Structure of a thioredoxin-like 2fe-2s ferredoxin from aquifex aeolicus  Academic Article
• Structure of a trimeric nucleoporin complex reveals alternate oligomerization states  Academic Article
• Structure of a v3-containing hiv-1 gp120 core  Academic Article
• Structure of activated aconitase - formation of the 4fe-4s cluster in the crystal  Academic Article
• Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation  Academic Article
• Structure of an agonist-bound human A₂A adenosine receptor  Academic Article
• Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases  Academic Article
• Structure of avian aicar transformylase with a multisubstrate adduct inhibitor β-DADF identifies the folate binding site  Academic Article
• Structure of azotobacter vinelandii 7fe ferredoxin at 1.35 Å resolution and determination of the fe-s bonds with 0.01 Å accuracy  Academic Article
• Structure of botulinurn neurotoxin type d light chain at 1.65 Å resolution: Repercussions for vamp-2 substrate specificity  Academic Article
• Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5a resolution using amino-acid sequence data  Academic Article
• Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway  Academic Article
• Structure of hiv-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility  Academic Article
• Structure of human cyclophilin and its binding-site for cyclosporine-a determined by x-ray crystallography and NMR-spectroscopy  Academic Article
• Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site  Academic Article
• Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding  Academic Article
• Structure of mammalian poly(adp- ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element  Academic Article
• Structure of microsomal cytochrome p4502b4 complexed with the antifungal drug bifonazole - insight into p450 conformational plasticity and membrane interaction  Academic Article
• Structure of nitric oxide synthase oxygenase dimer with pterin and substrate  Academic Article
• Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab  Academic Article
• Structure of the CAD domain of caspase-activated DNase and interaction with the CAD domain of its inhibitor  Academic Article
• Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex  Academic Article
• Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone  Academic Article
• Structure of the DNA repair and replication endonuclease and exonuclease fen-1: Coupling DNA and pcna binding to fen-1 activity  Academic Article
• Structure of the DNA repair enzyme endonuclease iv and its DNA complex: Double-nucleotide flipping at abasic sites and three-metal-ion catalysis  Academic Article
• Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation  Academic Article
• Structure of the I-1 early intermediate of photoactive yellow protein by FTIR spectroscopy  Academic Article
• Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding  Academic Article
• Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain  Academic Article
• Structure of the actin-myosin complex and its implications for muscle-contraction  Academic Article
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• The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire  Academic Article
• The usher syndrome proteins cadherin 23 and harmonin form a complex by means of pdz-domain interactions  Academic Article
• The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin  Academic Article
• The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments  Academic Article
• The way things move: Looking under the hood of molecular motor proteins  Academic Article
• Thermodynamic analysis of purified human placental alpha-l-fucosidase  Academic Article
• Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase  Academic Article
• Thermodynamics of RNA-RNA duplexes with 2-or 4-thiouridines: implications for antisense design and targeting a group I intron  Academic Article
• Thiol ligation of two zinc atoms to a class I tRNA synthetase: evidence for unshared thiols and role in amino acid binding and utilization  Academic Article
• Thioredoxin catalyzes the s-nitrosation of the caspase-3 active site cysteine  Academic Article
• Three pairs of cysteine residues mediate both redox and Zn2+ modulation of the NMDA receptor  Academic Article
• Three photo-cross-linked complexes of yeast phenylalanine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases  Academic Article
• Three-dimensional EM structure of the ectodomain of integrin alpha V beta 3 in a complex with fibronectin  Academic Article
• Three-dimensional location of the main immunogenic region of the acetylcholine receptor  Academic Article
• Three-dimensional model of membrane-bound ribosomes obtained by electron microscopy  Academic Article
• Three-dimensional model of the human platelet integrin alpha(llb)beta(3) based on electron cryomicroscopy and x-ray crystallography  Academic Article
• Three-dimensional solution structure of a single zinc finger DNA-binding domain  Academic Article
• Three-dimensional solution structure of the reduced form of Escherichia coli thioredoxin determined by nuclear magnetic resonance spectroscopy  Academic Article
• Three-dimensional structure of brush border myosin-i at similar to 20 Å resolution by electron microscopy and image analysis  Academic Article
• Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin  Academic Article
• Tissue factor - molecular recognition and cofactor function  Academic Article
• Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity  Academic Article
• Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta(3) subunit  Academic Article
• Topography of the high-affinity lysine binding site of plasminogen as defined with a specific antibody probe  Academic Article
• Total syntheses and initial evaluation of [?[C(-S)NH]Tpg(4)]vancomycin, [?[C(-NH)NH]Tpg(4)]vancomycin, [?[CH2NH]Tpg(4)]vancomycin, and their (4-Chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptide antibiotics  Academic Article
• Total synthesis of Psi C(=NH)NH Tpg(4) vancomycin and its ((4)-chlorobiphenyl)methyl derivative: impact of peripheral modifications on vancomycin analogues redesigned for dual D-Ala-D-Ala and D-Ala-D-Lac binding  Academic Article
• Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5 '-gnn-3 ' DNA target sequences  Academic Article
• Toward understanding the structural basis of partial agonism at the dopamine D-3 receptor  Academic Article
• Transcript leader regions of two saccharomyces cerevisiae mrnas contain internal ribosome entry sites that function in living cells  Academic Article
• Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)to-DJ(H) rearrangement of immunoglobulin genes  Academic Article
• Transcription inactivation through local refolding of the RNA polymerase structure  Academic Article
• Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9  Academic Article
• Transcriptional regulation of BCL-2 by nuclear factor kappa B and its significance in prostate cancer  Academic Article
• Transcriptional regulation of the mouse fatty acid amide hydrolase gene  Academic Article
• Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis  Academic Article
• Transfer RNA: from minihelix to genetic code  Academic Article
• Transfer of flexibility between ankyrin repeats in i kappa b alpha upon formation of the nf-kappa b complex  Academic Article
• Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase  Academic Article
• Trapping and characterization of novel retinoid response elements  Academic Article
• Trapping the dynamic acyl carrier protein in fatty acid biosynthesis  Academic Article
• Trial for peptide bond formation using model molecules based on the interactions between the CCA sequence of tRNA and 23S rRNA  Academic Article
• Tropomodulin binds to filensin intermediate filaments  Academic Article
• Tropomodulin contains two actin filament pointed end-capping domains  Academic Article
• Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin  Academic Article
• Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein  Academic Article
• Two classes of binding sites for uncoating protein in clathrin triskelions  Academic Article
• Two classes of cholesterol binding sites for the β2AR revealed by thermostability and NMR  Academic Article
• Two classes of tRNA synthetases suggested by sterically compatible dockings on tRNA acceptor stem  Academic Article
• Two estrogen receptors in reproductive tissue  Academic Article
• Two ligands may bind simultaneously to the muscarine receptor  Academic Article
• Two mutations in the promoter region of the human protein-C gene both cause type-I protein-C deficiency by disruption of 2 HNF-3 binding-sites  Academic Article
• Two photo-cross-linked complexes of isoleucine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases  Academic Article
• Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa  Academic Article
• Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides  Academic Article
• Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines  Academic Article
• Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors  Academic Article
• Type-III omega-agatoxins - a family of probes for similar binding-sites on L-type and N-type calcium channels  Academic Article
• Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2 '-deoxyuridine 5 '-monophosphate  Academic Article
• Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120  Academic Article
• Uba domains mediate protein-protein interactions between two DNA damage-inducible proteins  Academic Article
• Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2  Academic Article
• Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates  Academic Article
• Ubiquitylation of cyclin e requires the sequential function of scf complexes containing distinct hcdc4 isoforms  Academic Article
• Understanding the enzymatic activity of 4-oxalocrotonate tautomerase and its mutant analogues: A computational study  Academic Article
• Understanding the recognition of transfer RNAs by aminoacyl transfer RNA synthetases  Academic Article
• Unexpected acetylcholinesterase activity of cocaine esterases  Academic Article
• Unexpected ca2+-binding properties of synaptotagmin 9  Academic Article
• Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase  Academic Article
• Unique interactions of asialo von Willebrand factor with platelets in platelet-type von Willebrand disease  Academic Article
• Unmasking of CD22 co-receptor on germinal center B-cells occurs by alternative mechanisms in mouse and man  Academic Article
• Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease iv  Academic Article
• Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein lb  Academic Article
• Upstream activation sequence-dependent alteration of chromatin structure and transcription activation of the yeast GAL1-GAL10 genes  Academic Article
• Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects  Academic Article
• Use of phage display and transition-state analogs to select enzyme variants with altered catalytic properties: Glutathione transferase as an example  Academic Article
• Use of sialic-acid analogs to define functional-groups involved in binding to the influenza-virus hemagglutinin  Academic Article
• Using AutoDock for ligand-receptor docking  Academic Article
• Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task  Academic Article
• Using the process of reactive immunization to induce catalytic antibodies with complex mechanisms: Aldolases  Academic Article
• Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: Murine alpha 8 beta 1 binds to the rgd site in tenascin-c fragments, but not to native tenascin-c  Academic Article
• V-jun encodes a nuclear protein with enhancer binding properties of ap-1  Academic Article
• Vaccine elicitation of high mannose-dependent neutralizing antibodies against the V3-glycan broadly neutralizing epitope in nonhuman primates  Academic Article
• Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign  Academic Article
• Vaccine-elicited tier 2 HIV-1 neutralizing antibodies bind to quaternary epitopes involving glycan-deficient patches proximal to the CD4 binding site  Academic Article
• Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention  Academic Article
• Variable loop glycan dependency of the broad and potent hiv-1-neutralizing antibodies pg9 and pg16  Academic Article
• Variation and control of specific antigen-binding cell-populations in individual fetal mice  Academic Article
• Vinculin binding in its closed conformation by a helix addition mechanism  Academic Article
• Virtual screening against acetylcholine binding protein  Academic Article
• Virtual screening against alpha-cobratoxin  Academic Article
• Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors  Academic Article
• Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challenge  Academic Article
• Virus yoga: The role of flexibility in virus host cell recognition  Academic Article
• Virus-induced immune complex disease: specific anti-viral antibody and C1q binding material in the circulation during persistent lymphocytic choriomeningitis virus infection  Academic Article
• Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide  Academic Article
• Voronoi binding site model of a polycyclic aromatic hydrocarbon binding protein  Academic Article
• Water-soluble, recombinant cu-a-domain of the cytochrome ba(3) subunit ii from thermus thermophilus  Academic Article
• What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?  Academic Article
• White matter NMDA receptors: an unexpected new therapeutic target?  Academic Article
• Wrn exonuclease structure and molecular mechanism imply an editing role in DNA end processing  Academic Article
• X-pro peptide-bond as an NMR probe for conformational studies of flexible linear peptides  Academic Article
• X-ray absorption studies of the Zn2+ site of glyoxalase I  Academic Article
• X-ray absorption studies of the copper-beta domain of rat-liver metallothionein  Academic Article
• X-ray crystallographic determination of the structure of the influenza c virus haemagglutinin-esterase-fusion glycoprotein  Academic Article
• X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus  Academic Article
• X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease  Academic Article
• X-ray structure of junctional adhesion molecule: Structural basis for homophilic adhesion via a novel dimerization motif  Academic Article
• X-ray structure of metallothionein  Academic Article
• X-ray structures of the LXRα LBD in its homodimeric form and implications for heterodimer signaling  Academic Article
• Xyloglucan sidechains modulate binding to cellulose during in vitro binding assays as predicted by conformational dynamics simulations  Academic Article
• Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway  Academic Article
• Yeast glyoxalase I is a monomeric enzyme with two active sites  Academic Article
• Yy1 binding to a subset of p53 DNA-target sites regulates p53-dependent transcription  Academic Article
• ZiF-Predict: a web tool for predicting DNA-binding specificity in C2H2 zinc finger proteins  Academic Article
• Zinc finger tools: Custom DNA-binding domains for transcription factors and nucleases  Academic Article
• Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology  Academic Article
• Zinc-dependent cell growth conferred by mutant tRNA synthetase  Academic Article
• Zinc-dependent tRNA binding by a peptide element within a tRNA synthetase  Academic Article
• Zinc-free and reduced t4 gene-32 protein binds single-stranded-DNA weakly and fails to stimulate uvsx-catalyzed homologous pairing  Academic Article
• Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB  Academic Article
• hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene  Academic Article
• p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses  Academic Article
• von Willebrand factor has more than one binding site for platelets  Academic Article
• von Willebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism  Academic Article
• γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin  Academic Article