subject area of
- 1.35 and 2.07 a resolution structures of the red abalone sperm lysin monomer and dimer reveal features involved in receptor binding Academic Article
- 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase Academic Article
- 2,5-diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3) Academic Article
- 2-(3,5-dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor Academic Article
- 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport Academic Article
- 3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting Academic Article
- 3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle Academic Article
- 3D domain swapping modulates the stability of members of an icosahedral virus group Academic Article
- 4-Aminoindazolyl-dihydrofuro 3,4-d pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase Academic Article
- A Disorder-to-Order Transition Activates an ATP-Independent Membrane Protein Chaperone Academic Article
- A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs Academic Article
- A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model Academic Article
- A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis Academic Article
- A base triple in the tetrahymena group i core affects the reaction equilibrium via a threshold effect Academic Article
- A binding site for homeodomain and pax proteins is necessary for l1 cell adhesion molecule gene expression by pax-6 and bone morphogenetic proteins Academic Article
- A binding site for pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord Academic Article
- A branching reaction mechanism of glutathione reductase Academic Article
- A brassinosteroid transcriptional network revealed by genome-wide identification of BESI target genes in Arabidopsis thaliana Academic Article
- A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding Academic Article
- A cell cycle phosphoproteome of the yeast centrosome Academic Article
- A chemical, genetic, and structural analysis of the nuclear bile acid receptor fxr Academic Article
- A chemically functionalized magnetic nanoplatform for rapid and specific biomolecular recognition and separation Academic Article
- A chromatin binding-site in the tail domain of nuclear lamins that interacts with core histones Academic Article
- A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease Academic Article
- A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPAR gamma partial agonists Academic Article
- A complex assembly landscape for the 30S ribosomal subunit Academic Article
- A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis Academic Article
- A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles Academic Article
- A conserved hiv gp120 glycoprotein structure involved in chemokine receptor binding Academic Article
- A conserved motif in the itk ph-domain is required for phosphoinositide binding and tcr signaling but dispensable for adaptor protein interactions Academic Article
- A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase Academic Article
- A de novo designed peptide ligase: A mechanistic investigation Academic Article
- A de novo protein binding pair by computational design and directed evolution Academic Article
- A density functional evaluation of an Fe(III)-Fe(IV) model diiron cluster: comparisons with ribonucleotide reductase intermediate X Academic Article
- A designed inhibitor of a CLC antiporter blocks function through a unique binding mode Academic Article
- A designed synthetic analogue of 4-OT is specific for a non-natural substrate Academic Article
- A detailed structural model of cytotactin - protein homologies, alternative rna splicing, and binding regions Academic Article
- A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons Academic Article
- A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120 Academic Article
- A dynamic search process underlies microRNA targeting Academic Article
- A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol) Academic Article
- A flexible interface between DNA ligase and pcna supports conformational switching and efficient ligation of DNA Academic Article
- A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking Academic Article
- A four-helical super-secondary structure Academic Article
- A fragment of human TrpRS as a potent antagonist of ocular angiogenesis Academic Article
- A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia-coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases Academic Article
- A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock Academic Article
- A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding Academic Article
- A g-protein alpha-subunit from asexual candida-albicans functions in the mating signal transduction pathway of saccharomyces-cerevisiae and is regulated by the a1-alpha-2 repressor Academic Article
- A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain Academic Article
- A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells Academic Article
- A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans Academic Article
- A genetically encoded diazirine photocrosslinker in Escherichia coli Academic Article
- A genetically encoded fluorescent amino acid Academic Article
- A global benchmark study using affinity-based biosensors Academic Article
- A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728 Academic Article
- A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B Academic Article
- A hierarchy of RNA subdomains in assembly of the central domain of the 30 S ribosomal subunit Academic Article
- A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs Academic Article
- A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV Academic Article
- A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein Academic Article
- A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS Academic Article
- A linear amino acid sequence involved in the interaction of t-PA with its endothelial cell receptor Academic Article
- A method for defining binding sites involved in protein-protein interactions: analysis of the binding of plasminogen activator inhibitor 1 to the somatomedin domain of vitronectin Academic Article
- A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase Academic Article
- A molecular switch regulating transcriptional repression and activation of PPARγ Academic Article
- A mutation in the human cyclin-dependent kinase interacting protein, ckshs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly Academic Article
- A new decoration for nitric oxide synthase - a zn(cys)4 site Academic Article
- A new mechanism of allostery in a G protein-coupled receptor dimer Academic Article
- A new model for binding of kinesin 13 to curved microtubule protofilaments Academic Article
- A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic c-1027 biosynthesis Academic Article
- A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A Academic Article
- A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase Academic Article
- A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties Academic Article
- A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma Academic Article
- A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va Academic Article
- A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1 Academic Article
- A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex Academic Article
- A novel role of the budding yeast separin esp1 in anaphase spindle elongation: Evidence that proper spindle association of esp1 is regulated by pds1 Academic Article
- A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity Academic Article
- A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site Academic Article
- A permutational approach toward protein-DNA recognition Academic Article
- A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis Academic Article
- A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding Academic Article
- A poly(A) binding protein functions in the chloroplast as a message-specific translation factor Academic Article
- A positive feedback loop controls transcription of the spoof gene, a component of the sporulation phosphorelay in bacillus-subtilis Academic Article
- A protein-S binding-site on C4b-binding protein involves beta-chain residues 31-45 Academic Article
- A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.Fem-3 mRNA complex Academic Article
- A random walk in oncogene space: The quest for targets Academic Article
- A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation Academic Article
- A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin Academic Article
- A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria Academic Article
- A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: Crystal structure of spo0f from bacillus subtilis Academic Article
- A retroviral-like metal binding motif in an aminoacyl-tRNA synthetase is important for tRNA recognition Academic Article
- A reversible reaction inside a self-assembled capsule Academic Article
- A ribozyme composed of only two different nucleotides Academic Article
- A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus Academic Article
- A role for ranbp1 in the release of crm1 from the nuclear pore complex in a terminal step of nuclear export Academic Article
- A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280 Academic Article
- A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib Academic Article
- A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis Academic Article
- A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases Academic Article
- A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta Academic Article
- A semisynthetic glutathione peroxidase with high catalytic efficiency: Selenoglutathione transferase Academic Article
- A shape-dependent hydrophobic effect for tetrazoles Academic Article
- A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth Academic Article
- A silencer element in the retinoblastoma tumor-suppressor gene Academic Article
- A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity Academic Article
- A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure Academic Article
- A single gal4 dimer can maximally activate transcription under physiological conditions Academic Article
- A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors Academic Article
- A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases Academic Article
- A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases Academic Article
- A small molecule inhibitor selective for a variant atp-binding site of the chaperonin groel Academic Article
- A source of response regulator autophosphatase activity: The critical role of a residue adjacent to the spo0f autophosphorylation active site Academic Article
- A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor Academic Article
- A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle Academic Article
- A sphingosine 1-phosphate receptor 2 selective allosteric agonist Academic Article
- A stapled p53 helix overcomes HDMX-mediated suppression of p53 Academic Article
- A steady-state kinetic model of butyrylcholinesterase from horse plasma Academic Article
- A steady-state-kinetic random mechanism for glutathione S-transferase A from rat liver. A model involving kinetically significant enzyme-product complexes in the forward reaction Academic Article
- A structural model for the high-valent intermediate Q of methane monooxygenase from broken-symmetry density functional and electrostatics calculations Academic Article
- A structural model for the prostate disease marker, human prostate-specific antigen Academic Article
- A structural perspective of the sequence variability within botulinum neurotoxin subtypes a1-a4 Academic Article
- A structure-activity study of nociceptin-(1-13)-peptide amide. Synthesis of analogues substituted in positions 0, 1, 3, 4 and 10 Academic Article
- A structured RNA motif locks Argonaute2:miR-122 onto the 5' end of the HCV genome Academic Article
- A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase Academic Article
- A synthetic receptor for phosphocholine esters Academic Article
- A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease Academic Article
- A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen Academic Article
- A translation-like cycle is a quality control checkpoint for maturing 40s ribosome subunits Academic Article
- A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5 Academic Article
- A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry Academic Article
- A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin mac-1 (cd11b cd18) Academic Article
- A universal entropy-driven mechanism for thioredoxin-target recognition Academic Article
- A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities Academic Article
- ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair Academic Article
- ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization Academic Article
- ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase Academic Article
- Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: The 3 ' ends justify the means Academic Article
- Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: Formation of a pterin radical is required for enzyme activity Academic Article
- Ablating adenovirus type 5 fiber-car binding and hi loop insertion of the sigyplp peptide generate an endothelial cell-selective adenovirus Academic Article
- Absence of G(i) proteins in the Sf9 insect cell. Characterization of the uncoupled recombinant N-formyl peptide receptor Academic Article
- Acceptor helix interactions in a class II tRNA synthetase: photoaffinity cross-linking of an RNA miniduplex substrate Academic Article
- Acceptor substrate-based selective inhibition of galactosyltransferases Academic Article
- Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gpl120 is sterically restricted on primary human immunodeficiency virus type 1 Academic Article
- Accessibility of nuclear chromatin by DNA binding polyamides Academic Article
- Acetylcholine recognition by a deep, biomimetic pocket Academic Article
- Acidophilic adaptations in the structure of Acetobacter aceti N-5-carboxyaminoimidazole ribonucleotide mutase (PurE) Academic Article
- Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements Academic Article
- Activation of Hageman factor in solid and fluid phases. A critical role of kallikrein Academic Article
- Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1 Academic Article
- Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete c-terminal domain Academic Article
- Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the a subunits Academic Article
- Activation of the redox-regulated chaperone hsp33 by domain unfolding Academic Article
- Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation Academic Article
- Active and alkylated human agt structures: A novel zinc site, inhibitor and extrahelical base binding Academic Article
- Active and inhibited human catalase structures: Ligand and nadph binding and catalytic mechanism Academic Article
- Active site binding modes of curcumin in HIV-1 protease and integrase Academic Article
- Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense Academic Article
- Active site modification of factor viia affects interactions of the protease domain with tissue factor Academic Article
- Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein Academic Article
- Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties Academic Article
- Active site residues of cyclophilin A are crucial for its signaling activity via CD147 Academic Article
- Active site structure of Rieske-type proteins: electron nuclear double resonance studies of isotopically labeled phthalate dioxygenase from Pseudomonas cepacia and Rieske protein from Rhodobacter capsulatus and molecular modeling studies of a Rieske center Academic Article
- Active site structure of class I ribonucleotide reductase intermediate X: a density functional theory analysis of structure, energetics, and spectroscopy Academic Article
- Active site-directed inhibition of rabbit cytochrome P-450 1 by amino-substituted steroids Academic Article
- Active thymus derived suppressor lymphocytes in human cord blood Academic Article
- Active, interactive, and inactive steroid-receptor mutants Academic Article
- Active-site and oligosaccharide recognition residues of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f Academic Article
- Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3 Academic Article
- Activity-based protein profiling for the functional annotation of enzymes Academic Article
- Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid) Academic Article
- Adaptation of influenza viruses to human airway receptors Academic Article
- Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2 Academic Article
- Adding L-3-(2-naphthyl)alanine to the genetic code of E. coli Academic Article
- Addition of an alpha-hydroxy acid to the genetic code of bacteria Academic Article
- Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope Academic Article
- Adenosine: a partial agonist of the growth hormone secretagogue receptor Academic Article
- Adhesive properties of the isolated amino-terminal domain of platelet glycoprotein Ib alpha in a flow field Academic Article
- Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenge Academic Article
- Advances in pain therapeutics Academic Article
- Affinity labeling of creatine kinase by N-(2,3-epoxypropyl)-N-amidinoglycine Academic Article
- Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling Academic Article
- Agonist-bound structure of the human P2Y(12) receptor Academic Article
- Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence Academic Article
- Alanine scanning mutagenesis of an alpha beta T cell receptor: mapping the energy of antigen recognition Academic Article
- Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA Academic Article
- Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition Academic Article
- Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase Academic Article
- Aldehyde dehydrogenase inhibitors: A comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application Academic Article
- Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors Academic Article
- Allosteric inhibition of hypoxia inducible factor-2 with small molecules Academic Article
- Allosteric inhibition via R-state destabilization in ATP sulfurylase from Penicillium chrysogenum Academic Article
- Alternative outcomes in assembly of promoter complexes: The roles of TBP and a flexible linker in placing TFIIIB on tRNA genes Academic Article
- Amino acid derived quinazolines as Rock/PKA inhibitors Academic Article
- Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles Academic Article
- Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib Academic Article
- Amino acid substitution at the dimeric interface of human manganese superoxide dismutase Academic Article
- Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase Academic Article
- Aminoacylation of RNA minihelices: implications for tRNA synthetase structural design and evolution Academic Article
- Aminoglycoside binding in the major groove of duplex rna: The thermodynamic and electrostatic forces that govern recognition Academic Article
- Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase Academic Article
- An AP-1 site is involved in the NGF induction of IL-1α in PC12 cells Academic Article
- An Engineered Arginine Residue of Unusual pH-Sensitive Reactivity Facilitates Site-Selective Antibody Conjugation Academic Article
- An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines Academic Article
- An L-RNA aptamer that binds and inhibits RNase Academic Article
- An NMR perspective on enzyme dynamics Academic Article
- An RNA binding site in a tRNA synthetase with a reduced set of amino acids Academic Article
- An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors Academic Article
- An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide Academic Article
- An acyloxymethyl ketone-based probe to monitor the activity of glutathionylspermidine amidase in Escherichia coli Academic Article
- An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1 Academic Article
- An alternate binding site for PPARγ ligands Academic Article
- An alternative processing of integrin αv subunit in tumor cells by membrane type-1 matrix metalloproteinase Academic Article
- An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance Academic Article
- An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode Academic Article
- An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription Academic Article
- An analysis of a class of DNA sequence reading molecules Academic Article
- An aptamer that neutralizes r5 strains of hiv-1 binds to core residues of gp120 in the ccr5 binding site Academic Article
- An aptamer that neutralizes r5 strains of human immunodeficiency virus type 1 blocks gp120-ccr5 interaction Academic Article
- An engineered mutant of hiv-1 gp120 formulated with adjuvant quil a promotes elicitation of antibody responses overlapping the cd4-binding site Academic Article
- An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured Academic Article
- An essential histidine residue in the catalytic mechanism of mammalian glutathione reductase Academic Article
- An essential role for the conserved Glu-133 in the anion interaction with superoxide-dismutase Academic Article
- An evolutionary approach to the design of glutathione-linked enzymes Academic Article
- An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity Academic Article
- An improved zinc-finger nuclease architecture for highly specific genome editing Academic Article
- An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation Academic Article
- An inhibitor of sequence-specific proteolysis that targets the substrate rather than the enzyme Academic Article
- An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity Academic Article
- An integrated map of genetic variation from 1,092 human genomes Academic Article
- An intramolecular signaling element that modulates dynamin function in vitro and in vivo Academic Article
- An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin 5 Academic Article
- An o-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses Academic Article
- An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution Academic Article
- An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7 Academic Article
- An operational RNA code for amino acids and variations in critical nucleotide sequences in evolution Academic Article
- An oxetane-based polyketide surrogate To probe substrate binding in a polyketide synthase Academic Article
- An unusual dimeric structure and assembly for tlr4 regulator rp105-md-1 Academic Article
- Analysis of bacteriophage N protein and peptide binding to boxB RNA using polyacrylamide gel coelectrophoresis (PACE) Academic Article
- Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes Academic Article
- Analysis of hapten binding and catalytic determinants in a family of catalytic antibodies Academic Article
- Analysis of structure-function relationships in the platelet membrane glycoprotein Ib-binding domain of von Willebrand's factor by expression of deletion mutants Academic Article
- Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo Academic Article
- Analysis of the class i aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99 Å resolution Academic Article
- Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity Academic Article
- Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera Academic Article
- Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: Insight into the chaotrope unfolding dichotomy Academic Article
- Anisotropic molecular rotational diffusion in n-15 spin relaxation studies of protein mobility Academic Article
- Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists Academic Article
- Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres Academic Article
- Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones Academic Article
- Anti-diabetic drug binding site in a mammalian K-ATP channel revealed by Cryo-EM Academic Article
- Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen Academic Article
- Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides Academic Article
- Antibodies raised against beta-adrenergic receptors stimulate adenylate-cyclase Academic Article
- Antibody 2g12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the hiv-1 glycan shield if domain exchanged Academic Article
- Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike Academic Article
- Antibody binding defines a structure for an epitope that participates in the prpc -> prpsc conformational change Academic Article
- Antibody catalysis of the oxidation of water Academic Article
- Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics Academic Article
- Antibody microarrays utilizing site-specific antibody-oligonucleotide conjugates Academic Article
- Antibody neutralization epitopes and integrin binding sites on nonenveloped viruses Academic Article
- Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env Academic Article
- Antibody structure and molecular immunology Academic Article
- Antibody structure, diversity, and specificity Academic Article
- Antibody vs. HIV in a clash of evolutionary titans Academic Article
- Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions Academic Article
- Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation Academic Article
- Anticodon G recognition by tRNA synthetases mimics the tRNA core Academic Article
- Antifungal azoles: structural insights into undesired tight binding to cholesterol-metabolizing CYP46A1 Academic Article
- Antigen recognition by variable lymphocyte receptors Academic Article
- Antiidiotype and antihormone receptor antibodies Academic Article
- Antimitotic agents of natural origin Academic Article
- Ap-2/eps15 interaction is required for receptor-mediated endocytosis Academic Article
- Apo raver1 structure reveals distinct RRM domain orientations Academic Article
- Application of nuclear magnetic-resonance spectroscopy to proteins Academic Article
- Approaches toward selective inhibition of nitric oxide synthase Academic Article
- Aptly named aptamers display their aptitude Academic Article
- Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation Academic Article
- Archaeal flagellar atpase motor shows atp-dependent hexameric assembly and activity stimulation by specific lipid binding Academic Article
- Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors Academic Article
- Architecture of the mediator head module Academic Article
- Arginine-54 in the active-site of escherichia-coli aspartate transcarbamoylase is critical for catalysis - a site-specific mutagenesis, NMR, and x-ray crystallographic study Academic Article
- Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions Academic Article
- Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor Academic Article
- Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein Academic Article
- Aspartate-transcarbamylase lacking catalytic subunit interactions - study of conformational-changes by uv absorbance and circular-dichroism spectroscopy Academic Article
- Aspects of the molecular-structure of igg subclasses Academic Article
- Assembly of hybrid bacteriophage Qβ virus-like particles Academic Article
- Assembly of the ebola virus nucleoprotein from a chaperoned VP35 complex Academic Article
- Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure Academic Article
- Assessment of major and minor groove DNA interactions by the zinc fingers of xenopus transcription factor IIIA Academic Article
- Association of Sindbis virus capsid protein with phospholipid membranes and the E2 glycoprotein: implications for alphavirus assembly Academic Article
- Association of plasma apolipoproteins d with rbc membrane arachidonic acid levels in schizophrenia Academic Article
- Association of the cytoplasmic domain of intercellular-adhesion molecule-1 with glyceraldehyde-3-phosphate dehydrogenase and beta-tubulin Academic Article
- Asymmetric DNA binding by a homodimeric bHLH protein Academic Article
- Asymmetric organic synthesis with catalytic antibodies Academic Article
- Atomic and residue hydrophilicity in the context of folded protein structures Academic Article
- Atomic coordinates and molecular-conformation of yeast phenylalanyl transfer-rna - independent investigation Academic Article
- Atomic coordinates for triose phosphate isomerase from chicken muscle Academic Article
- Atp induces conformational changes in the carboxyl-terminal region of clc-5 Academic Article
- Attachment of ribosome crystals to intracellular membranes Academic Article
- Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor Academic Article
- AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading Academic Article
- AutoDock4(Zn): an improved AutoDock force field for small-molecule docking to zinc metalloproteins Academic Article
- AutoDockFR: Advances in protein-ligand docking with explicitly specified binding site flexibility Academic Article
- Autoactivation of avian urokinase-type plasminogen activator (upa) - a novel mode of initiation of the upa/plasmin cascade Academic Article
- Automated docking in crystallography: analysis of the substrates of aconitase Academic Article
- Automated docking of ligands to an artificial active site: augmenting crystallographic analysis with computer modeling Academic Article
- Automated docking of substrates to proteins by simulated annealing Academic Article
- Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase Academic Article
- Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications Academic Article
- Automated identification of functional dynamic contact networks from X-ray crystallography Academic Article
- Automated prediction of ligand-binding sites in proteins Academic Article
- Avian winged helix proteins CWH-1, CWH-2 and CWH-3 repress transcription from Qin binding sites Academic Article
- Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential Academic Article
- Azurin as a protein scaffold for a low-coordinate nonheme iron site with a small-molecule binding pocket Academic Article
- B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention Academic Article
- BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein Academic Article
- BMix: probabilistic modeling of occurring substitutions in PAR-CLIP data Academic Article
- BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint Academic Article
- BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases Academic Article
- Bacillus subtilis hydrolyzes chey-p at the location of its action, the flagellar switch Academic Article
- Backbone dynamics in dihydrofolate reductase complexes: Role of loop flexibility in the catalytic mechanism Academic Article
- Bacterial pleckstrin homology domains: A prokaryotic origin for the PH domain Academic Article
- Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery Academic Article
- Barx2 controls myoblast fusion and promotes MyoD-mediated activation of the smooth muscle alpha-actin gene Academic Article
- Basal lamina strengthens cell membrane integrity via the laminin g domain-binding motif of alpha-dystroglycan Academic Article
- Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA Academic Article
- Base pairing between hepatitis C virus RNA and 18S rRNA is required for IRES-dependent translation initiation in vivo Academic Article
- Beads-on-a-string, characterization of Ets-1 sumoylated within its flexible N-terminal sequence Academic Article
- Behavior of holo-forms and apo-forms of bovine superoxide-dismutase at low ph Academic Article
- Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: Towards a pharmacophore model for the nucleotide-binding domain Academic Article
- Benzoquinones as inhibitors of botulinum neurotoxin serotype A Academic Article
- Beta(2)-adrenergic receptor down-regulation - evidence for a pathway that does not require endocytosis Academic Article
- Beta-endorphin stimulates proliferation of small-cell lung-carcinoma cells in-vitro via nonopioid binding-sites Academic Article
- Biased signaling pathways in betaβ2-adrenergic receptor characterized by 19F-NMR Academic Article
- Bifunctional abletadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations Academic Article
- Bifunctional catalysis of proton transfer at an antibody active site Academic Article
- Big mitogen-activated kinase regulates multiple members of the mef2 protein family Academic Article
- Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells Academic Article
- Binding modes for the first coupled electron and proton addition to FeMoco of nitrogenase Academic Article
- Binding of 2-hydroxyestradiol to rat anterior pituitary cell membranes Academic Article
- Binding of AR-1-144, a tri-imidazole DNA minor groove binder, to CCGG sequence analyzed by NMR spectroscopy Academic Article
- Binding of [3H]-pilocarpine to membranes from rat cerebral cortex Academic Article
- Binding of a high-energy substrate conformer in antibody catalysis Academic Article
- Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms Academic Article
- Binding of a structured D-RNA molecule by an L-RNA aptamer Academic Article
- Binding of an HIV Rev peptide to Rev responsive element RNA induces formation of purine-purine base pairs Academic Article
- Binding of neural cell adhesion molecules (n-cams) to the cellular prion protein Academic Article
- Binding of proteins to cnbr-activated sepharose 4b Academic Article
- Binding of steroids to progesterone receptor proteins in chick oviduct and human uterus Academic Article
- Binding of the junction-resolving enzyme bacteriophage-T7 endonuclease-I to DNA - separation of binding and catalysis by mutation Academic Article
- Binding of the snake venom-derived proteins applaggin and echistatin to the arginine-glycine-aspartic acid recognition site(s) on platelet glycoprotein IIb.IIIa complex inhibits receptor function Academic Article
- Binding of tissue plasminogen activator to human monocytes and monocytoid cells Academic Article
- Binding of type 1 plasminogen activator inhibitor to the extracellular matrix of cultured bovine endothelial cells Academic Article
- Binding of α-thrombin to surface-anchored platelet glycoprotein Ibα sulfotyrosines through a two-site mechanism involving exosite I Academic Article
- Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va Academic Article
- Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va Academic Article
- Binding studies with intact rat prolactin and a 16K fragment of the hormone Academic Article
- Biochemical and structural analysis of nuclear protein import Academic Article
- Biochemical characterization and structural analysis of a highly proficient cocaine esterase Academic Article
- Biochemical characterization of the Caenorhabditis elegans FBF. CPB-1 translational regulation complex identifies conserved protein interaction hotspots Academic Article
- Biochemically defined hiv-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the cd4-binding site Academic Article
- Biochemistry. Ubiquitination - more than two to tango Academic Article
- Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase Academic Article
- Biophysical studies on the mechanism of quinacrine staining of chromosomes Academic Article
- Biosynthesis of the enediyne antitumor antibiotic c-1027 involves a new branching point in chorismate metabolism Academic Article
- Biotechnology of beta-adrenergic receptors Academic Article
- Bistable cucurbituril rotaxanes without stoppers Academic Article
- Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase Academic Article
- Blocking site-to-site translocation of a misactivated amino acid by mutation of a class I tRNA synthetase Academic Article
- Blocking transcription through a nucleosome with synthetic DNA ligands Academic Article
- Blood coagulation: The outstanding hydrophobic residues Academic Article
- BluB cannibalizes flavin to form the lower ligand of vitamin B-12 Academic Article
- Blue-fluorescent antibodies Academic Article
- Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds Academic Article
- Brassinosteroids control male fertility by regulating the expression of key genes involved in Arabidopsis anther and pollen development Academic Article
- Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase Academic Article
- Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody Academic Article
- Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals Academic Article
- Broad neutralization of SARS-related viruses by human monoclonal antibodies Academic Article
- Bromodomain proteins contribute to maintenance of bloodstream form stage identity in the African trypanosome Academic Article
- Buffer enhancement of proton-transfer in catalysis by human carbonic anhydrase-iii Academic Article
- Building zinc fingers by selection - toward a therapeutic application Academic Article
- Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase Academic Article
- C-13 nuclear magnetic-resonance studies of the selectively isotope-labeled reactive site peptide-bond of the basic pancreatic trypsin-inhibitor in the complexes with trypsin, trypsinogen, and anhydrotrypsin Academic Article
- C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock Academic Article
- C-o bond formation by polyketide synthases Academic Article
- C-terminal residues 621-635 of protein S are essential for binding to factor Va Academic Article
- C-terminal zinc-containing peptide required for RNA recognition by a class I tRNA synthetase Academic Article
- C/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment Academic Article
- C3 receptors on lymphoid-cells - isolation of active membrane fragments and solubilization of receptor complexes Academic Article
- C3-mediated cytoadherence - formation of c3 receptor aggregates as prerequisite for cell attachment Academic Article
- C5L2, a nonsignaling C5A binding protein Academic Article
- CBI-CDPBO1 and CBI-CDPBI1 - CC-1065 analogs containing deep-seated modifications in the DNA-binding subunit Academic Article
- CC-1065 CBI analogs - an example of enhancement of DNA alkylation efficiency through introduction of stabilizing electrostatic interactions Academic Article
- CC-1065 and the duocarmycins - unraveling the keys to a new class of naturally derived DNA alkylating-agents Academic Article
- CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells Academic Article
- CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5 Academic Article
- CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes Academic Article
- CSI-FID: high throughput label-free detection of DNA binding molecules Academic Article
- CYP2C8 exists as a dimer in natural membranes Academic Article
- Ca (2+)-induced rigidity change of the myosin VIIa IQ motif-single α helix lever arm extension Academic Article
- Ca2+ binding protects against gelsolin amyloidosis Academic Article
- Ca2+ binding to the first epidermal growth factor module of coagulation factor viia is important for cofactor interaction and proteolytic function Academic Article
- Calbindin D-28K interacts with Ran-binding protein M: Identification of interacting domains by NMR spectroscopy Academic Article
- Calcium binding sites of calmodulin and electron transfer by neuronal nitric oxide synthase Academic Article
- Calcium-binding sites of calmodulin and electron transfer by inducible nitric oxide synthase Academic Article
- Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence Academic Article
- Calculations of electrostatic interactions and pK(a)s in the active site of Escherichia coli thioredoxin Academic Article
- Calmodulin stabilizes an amphiphilic alpha-helix within rc3/neurogranin and gap-43/neuromodulin only when ca2+ is absent Academic Article
- Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain Academic Article
- Carbamyl phosphate binding to aspartate transcarbamylase. Partial saturation and its alteration by succinate Academic Article
- Carbohydrate-encapsulated gold nanoparticles for rapid target-protein identification and binding-epitope mapping Academic Article
- Carbonic anhydrase inhibitors. Interaction of 2-n,n-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: Kinetic and x-ray crystallographic studies Academic Article
- Carrier protein recognition in siderophore-producing nonribosomal peptide synthetases Academic Article
- Cassette mutagenesis of a potential substrate recognition region of cytochrome P450 2C2 Academic Article
- Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: Crystal structures of abzyme 21D8 Academic Article
- Catalysis within the lipid bilayer - structure and mechanism of the mapeg family of integral membrane proteins Academic Article
- Catalytic and molecular properties of glyoxalase I. Academic Article
- Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection Academic Article
- Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: Insertion of valine Cγ into the substrate access channel Academic Article
- Catalytic antibodies Academic Article
- Catalytic antibodies Academic Article
- Catalytic antibodies - structure and function Academic Article
- Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine Academic Article
- Cd-113 nuclear magnetic-resonance studies of cadmium-substituted derivatives of bovine superoxide-dismutase Academic Article
- Cd22-antagonists with nanomolar potency: The synergistic effect of hydrophobic groups at c-2 and c-9 of sialic acid scaffold Academic Article
- Cell adhesion and migration are regulated at distinct stages of thymic t cell development: The roles of fibronectin, vla4, and vla5 Academic Article
- Cell cycle phosphorylation of mitotic exit network (MEN) proteins Academic Article
- Cell-free synthesis and segregation of beta-2-microglobulin Academic Article
- Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene Academic Article
- Challenges in enzyme mechanism and energetics Academic Article
- Changes in 3-dimensional structure of concanavalin-a upon demetallization Academic Article
- Changes in the relative occupancy of metal-binding sites in the profile structure of the sarcoplasmic-reticulum membrane induced by phosphorylation of the Ca2+ ATPase enzyme in the presence of terbium: a time-resolved, resonance x-ray-diffraction study Academic Article
- Characteristics of the energy-transducing nadh-quinone oxidoreductase of paracoccus-denitrificans as revealed by biochemical, biophysical, and molecular biological approaches Academic Article
- Characterization and inactivation of an agmatine deiminase from helicobacter pylori Academic Article
- Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase Academic Article
- Characterization and nucleotide binding-properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement Academic Article
- Characterization by (1)H NMR of a C32S,C35S double mutant of Escherichia coli thioredoxin confirms its resemblance to the reduced wild-type protein Academic Article
- Characterization of a binding-site for chemically synthesized lipo-oligosaccharidic nodrm factors in particulate fractions prepared from roots Academic Article
- Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site Academic Article
- Characterization of a gene encoding a DNA binding protein with specificity for a light-responsive element Academic Article
- Characterization of a nuclear deformed epidermal autoregulatory factor-1 (DEAF-1)-related (NUDR) transcriptional regulator protein Academic Article
- Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va Academic Article
- Characterization of active-site residues of the nia protease from tobacco vein mottling virus Academic Article
- Characterization of factor-vii association with tissue factor in solution - high and low affinity calcium-binding sites in factor-vii contribute to functionally distinct interactions Academic Article
- Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry Academic Article
- Characterization of nuclear RNases that cleave hepatitis B virus RNA near the LA protein binding site Academic Article
- Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro Academic Article
- Characterization of the DNA binding properties of the bHLH domain of Deadpan to single and tandem sites Academic Article
- Characterization of the Runx gene family in a jawless vertebrate, the Japanese lamprey (Lethenteron japonicum) Academic Article
- Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands Academic Article
- Characterization of the core mammalian clock component, NPAS2, as a REV-ERB alpha/ROR alpha target gene Academic Article
- Characterization of the electrophile binding site and substrate binding mode of the 26-kda glutathione s-transferase from schistosoma japonicum Academic Article
- Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts Academic Article
- Characterization of the initial alpha-thrombin interaction with glycoprotein Ib alpha in relation to platelet activation Academic Article
- Characterization of the interaction of lassa fever virus with its cellular receptor alpha-dystroglycan Academic Article
- Characterization of the iron-sulfur cluster n7 (n1c) in the subunit nuog of the proton-translocating nadh-quinone oxidoreductase from escherichia coli Academic Article
- Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1 Academic Article
- Characterization of the nuom (nd4) subunit in escherichia coli ndh-1 - conserved charged residues essential for energy-coupled activities Academic Article
- Characterization of the promoter region and flanking sequences of the neuron-specific gene rc3 (neurogranin) Academic Article
- Characterization of the ubiquinone binding site in the alternative nadh-quinone oxidoreductase of saccharomyces cerevisiae by photoaffinity labeling Academic Article
- Characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy Academic Article
- Charting a path to success in virtual screening Academic Article
- Chemical approaches to nuclear receptors in metabolism Academic Article
- Chemical characterization of ligand-binding site fragments from turkey beta-adrenergic-receptor Academic Article
- Chemical expansion of cofactor activity Academic Article
- Chemical markers of transplantation individuality solubilized with sonic energy Academic Article
- Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferases Academic Article
- Chemical shift as a probe of molecular interfaces: Nmr studies of DNA binding by the three amino-terminal zinc finger domains from transcription factor iiia Academic Article
- Chemically programmed antibodies Academic Article
- Chemically regulated zinc finger transcription factors Academic Article
- Chemistry and molecular biology of galanin receptor ligands Academic Article
- Chemistry for the analysis of protein-protein interactions: Rapid and efficient cross-linking triggered by long wavelength light Academic Article
- Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environment Academic Article
- Chemotype-selective modes of action of κ-opioid receptor agonists Academic Article
- Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins Academic Article
- Cholesterol seco-sterol-induced aggregation of methylated amyloid-β peptides - insights into aldehyde-initiated fibrillization of amyloid-β Academic Article
- Chromaffin cell plasminogen receptors Academic Article
- Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway Academic Article
- Chromosomal integration dependent induction of junb by growth factors requires multiple flanking evolutionarily conserved sequences Academic Article
- Circadian clock- and phytochrome-regulated transcription is conferred by a 78 bp cis-acting domain of the Arabidopsis CAB2 promoter Academic Article
- Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP Academic Article
- Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase Academic Article
- Cis-preferential recruitment of duck hepatitis B virus core protein to the RNA/polymerase preassembly complex Academic Article
- Cisregulation and transregulation of feline immunodeficiency virus - identification of functional binding-sites in the long terminal repeat Academic Article
- Citrullination regulates pluripotency and histone H1 binding to chromatin Academic Article
- Classification of variant von Willebrand's disease subtypes by analysis of functional characteristics and multimeric composition of factor VIII/von Willebrand factor Academic Article
- Click chemistry in situ: Acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks Academic Article
- Clinical Antiviral Drug Arbidol Inhibits Infection by SARS-CoV-2 and Variants through Direct Binding to the Spike Protein Academic Article
- Cloning of cdnas for m-phase phosphoproteins recognized by the mpm2 monoclonal-antibody and determination of the phosphorylated epitope Academic Article
- Cloning of the murine platelet glycoprotein Ib alpha gene highlighting species-specific platelet adhesion Academic Article
- Closing the gate to the active site: Effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase Academic Article
- Co-evolving motions at protein-protein interfaces of two-component signaling systems identified by covariance analysis Academic Article
- Co-folding of a FliF-FliG split domain forms the basis of the MS:C ring interface within the bacterial flagellar motor Academic Article
- Coactivators PGC-1 beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen Academic Article
- Cofactor residues lysine-165 and lysine-166 are critical for protein substrate recognition by the tissue factor-factor-viia protease complex Academic Article
- Cohesin-mediated chromatin interactions-into the third dimension of gene regulation Academic Article
- Combining chemoselective ligation with polyhistidine-driven self-assembly for the modular display of biomolecules on quantum dots Academic Article
- Combining structural genomics and enzymology: Completing the picture in metabolic pathways and enzyme active sites Academic Article
- Comparative modeling of the three CP modules of the beta-chain of C4BP and evaluation of potential sites of interaction with protein S Academic Article
- Comparison of NMR and crystal structures highlights conformational isomerism in protein active sites Academic Article
- Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster Academic Article
- Comparison of isotope labeling patterns of purines in three specific transfer RNAs Academic Article
- Comparison of the NMR solution structure and the x-ray crystal-structure of rat metallothionein-2 Academic Article
- Comparison of the NMR solution structure with the x-ray crystal-structure of the activation domain from procarboxypeptidase-b Academic Article
- Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease Academic Article
- Comparison of the lysine binding functions of lipoprotein(a) and plasminogen Academic Article
- Competition between plasminogen and tissue plasminogen activator for cellular binding sites Academic Article
- Complementary use of chemical modification and site-directed mutagenesis to probe structure activity relationships in enzymes Academic Article
- Complete assignment of the h-1-NMR spectrum of a synthetic zinc finger from xfin - sequential resonance assignments and secondary structure Academic Article
- Complete inhibition of cdk/cyclin by one molecule of p21(cip1) Academic Article
- Complete n-15 and h-1-NMR assignments for the amino-terminal domain of the phage 434 repressor in the urea-unfolded form Academic Article
- Complete subunit architecture of the proteasome regulatory particle Academic Article
- Complete thermodynamic characterization of reduction and protonation of the bc(1)-type rieske 2fe-2s center of thermus thermophilus Academic Article
- Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci Academic Article
- Complex-formation between bovine neurophysin-I and oxytocin, vasopressin, and tripeptide analogs of their NH2-terminal region - absorbance and circular-dichroism difference spectroscopic studies Academic Article
- Comprehensive high-resolution analysis of hairpin polyamides utilizing a fluorescent intercalator displacement (FID) assay Academic Article
- Computational approaches to detect allosteric pathways in transmembrane molecular machines Academic Article
- Computational design of proteins targeting the conserved stem region of influenza hemagglutinin Academic Article
- Computational evaluation of protein-small molecule binding Academic Article
- Computational fragment-based binding site identification by ligand competitive saturation Academic Article
- Computational predictions suggest that structural similarity in viral polymerases may lead to comparable allosteric binding sites Academic Article
- Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase Academic Article
- Concanavalin a derivatives with altered biological activities Academic Article
- Concerted kinetic folding of a multidomain ribozyme with a disrupted loop-receptor interaction Academic Article
- Condensin I and II complexes license full estrogen receptor α-dependent enhancer activation Academic Article
- Conformation of the TAR RNA-arginine complex by NMR spectroscopy Academic Article
- Conformational change in the nadp(h) binding domain of transhydrogenase defines four states Academic Article
- Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S Academic Article
- Conformational changes in aspartate trancarbamylase. I. Studies of ligand binding and of subunit interactions by circular dichroism spectroscopy Academic Article
- Conformational changes in aspartate transcarbamylase. II. Circular dichroism evidence for the involvement of metal ions in allosteric interactions Academic Article
- Conformational changes in concanavalin a Academic Article
- Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency Academic Article
- Conformational dynamics of a membrane protein chaperone enables spatially regulated substrate capture and release Academic Article
- Conformational flexibility in crystal structures of human 11 β-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation Academic Article
- Conformational flexibility in the flap domains of ligand-free HIV protease Academic Article
- Conformational isomerism can limit antibody catalysis Academic Article
- Conformational polymorphism of cyclosporine-a Academic Article
- Conformational preferences of synthetic peptides derived from the immunodominant site of the circumsporozoite protein of Plasmodium falciparum by (1)H NMR Academic Article
- Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis Academic Article
- Conformational states of cytochrome p450cam revealed by trapping of synthetic molecular wires Academic Article
- Conformational switching in the fungal light sensor vivid Academic Article
- Conserved binding mode of human beta(2) adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography Academic Article
- Conserved structural motifs governing the stoichiometric repair of alkylated DNA by o-6-alkylguanine-DNA alkyltransferase Academic Article
- Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c Academic Article
- Contact-shifted resonances in h-1 NMR-spectra of cytochrome b5 - resonance identification and spin-density distribution in heme group Academic Article
- Contemporary paradigms for cholinergic ligand design guided by biological structure Academic Article
- Contribution of amino acid residue 208 in the hydrophobic binding site to the catalytic mechanism of human glutathione transferase A1-1 Academic Article
- Contribution of five amino acid residues in the glutathione-binding site to the function of human glutathione transferase P1-1 Academic Article
- Contributions of individual nucleotides to tertiary binding of substrate by a Pneumocystis carinii group I intron Academic Article
- Control of crosslinking by quaternary structure changes during bacteriophage hk97 maturation Academic Article
- Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification Academic Article
- Controlling amyloid beta-peptide fibril formation with protease-stable ligands Academic Article
- Controlling gene expression in plants using synthetic zinc finger transcription factors Academic Article
- Conversion of n-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-damp mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues Academic Article
- Converting an injectable protein therapeutic into an oral form: Phenylalanine ammonia lyase for phenylketonuria Academic Article
- Convulxin binds to native, human glycoprotein IIbα Academic Article
- Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site Academic Article
- Cooperative binding of magnesium to transfer ribonucleic acid studied by a fluorescent probe Academic Article
- Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study Academic Article
- Cooperativity in transcription factor binding to the coactivator creb-binding protein (cbp) - the mixed lineage leukemia protein (mll) activation domain binds to an allosteric site on the kix domain Academic Article
- Coordination of the heme iron in the low-potential cytochromes c-553 from desulfovibrio-vulgaris and desulfovibrio-desulfuricans - different chirality of the axially bound methionine in the oxidized and reduced states Academic Article
- Copper binding to the prion protein: structural implications of four identical cooperative binding sites Academic Article
- Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast Academic Article
- Cortistatin a is a high-affinity ligand of protein kinases rock, cdk8, and cdk11 Academic Article
- Cortistatin and somatostatin mrnas are differentially regulated in response to kainate Academic Article
- Coumarin derivatives as substrate probes of mammalian cytochromes P450 2B4 and 2B6: assessing the importance of 7-Alkoxy chain length, halogen substitution, and non-active site mutations Academic Article
- Coupled redox potentials in manganese and iron superoxide dismutases from reaction kinetics and density functional/electrostatics calculations Academic Article
- Coupling of receptor conformation and ligand orientation determine graded activity Academic Article
- Covalent and 3-dimensional structure of concanavalin-a .1. Amino-acid sequence of cyanogen-bromide fragments f1 and f2 Academic Article
- Covalent and 3-dimensional structure of concanavalin-a .2. Amino-acid sequence of cyanogen-bromide fragment f3 Academic Article
- Covalent and 3-dimensional structure of concanavalin-a .3. Structure of monomer and its interactions with metals and saccharides Academic Article
- Covalent and 3-dimensional structure of concanavalin-a .4. Atomic coordinates, hydrogen-bonding, and quaternary structure Academic Article
- Creatine-kinase - nuclear magnetic-resonance and fluorescence evidence for interaction of adenosine 5'-diphosphate with aromatic residue(s) Academic Article
- Criteria for selecting PEGylation sites on proteins for higher thermodynamic and proteolytic stability Academic Article
- Cross-neutralization of influenza a viruses mediated by a single antibody loop Academic Article
- Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer Academic Article
- Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex Academic Article
- Cryo-electron microscopy of S1-decorated actin filaments Academic Article
- Cryo-em visualization of an exposed rgd epitope on adenovirus that escapes antibody neutralization Academic Article
- Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis Academic Article
- Crystal structure and novel recognition motif of rho adp-ribosylating c3 exoenzyme from clostridium botulinum: Structural insights for recognition specificity and catalysis Academic Article
- Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase Academic Article
- Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 Å resolution reveals a new fold with a novel active site Academic Article
- Crystal structure of 3-hydroxyanthranilic acid 3,4-dioxygenase from saccharomyces cerevisiae: A special subgroup of the type III extradiol dioxygenases Academic Article
- Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 Å resolution Academic Article
- Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A Academic Article
- Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism Academic Article
- Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif Academic Article
- Crystal structure of NMA 1982 from Neisseria meningiddis at 1.5 Å resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases Academic Article
- Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution Academic Article
- Crystal structure of Pasteurella haemolytica ferric ion-binding protein a reveals a novel class of bacterial iron-binding proteins Academic Article
- Crystal structure of TM1367 from Thermotoga maritima at 1.90 Å resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold Academic Article
- Crystal structure of Trbp111: a structure-specific tRNA-binding protein Academic Article
- Crystal structure of UbiX, an aromatic acid decarboxylase from the psychrophilic bacterium Colwellia psychrerythraea that undergoes FMN-induced conformational changes Academic Article
- Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution Academic Article
- Crystal structure of a bacterial cocaine esterase Academic Article
- Crystal structure of a bifunctional deaminase and reductase from Bacillus subtilis involved in riboflavin biosynthesis Academic Article
- Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis Academic Article
- Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution Academic Article
- Crystal structure of a divalent metal ion transporter CorA at 2.9 Å resolution Academic Article
- Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold Academic Article
- Crystal structure of a gamma delta t cell receptor ligand t22: A truncated mhc-like fold Academic Article
- Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity Academic Article
- Crystal structure of a lipid G protein-coupled receptor Academic Article
- Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity Academic Article
- Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution Academic Article
- Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch Academic Article
- Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design Academic Article
- Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design Academic Article
- Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 Å resolution Academic Article
- Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 Å resolution Academic Article
- Crystal structure of a phosphatase-resistant mutant of sporulation response regulator spo0f from bacillus subtilis Academic Article
- Crystal structure of a putative NADPH-dependent oxidoreductase (GI : 18204011) from mouse at 2.10 Å resolution Academic Article
- Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 Å resolution Academic Article
- Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 a resolution Academic Article
- Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3 Academic Article
- Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 Å resolution Academic Article
- Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design Academic Article
- Crystal structure of an isolated V(alpha) domain of the 2C T-cell receptor Academic Article
- Crystal structure of antagonist bound human lysophosphatidic acid receptor 1 Academic Article
- Crystal structure of atp sulfurylase from penicillium chrysogenum: Insights into the allosteric regulation of sulfate assimilation Academic Article
- Crystal structure of botulinum neuro-toxin type a and implications for toxicity Academic Article
- Crystal structure of botulinum neurotoxin type g light chain: Serotype divergence in substrate recognition Academic Article
- Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5 Academic Article
- Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition Academic Article
- Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping Academic Article
- Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue Academic Article
- Crystal structure of human ornithine transcarbamylase complexed with carbamoyl phosphate and L-norvaline at 1.9 A resolution Academic Article
- Crystal structure of human toll-like receptor 3 (tlr3) ectodomain Academic Article
- Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites Academic Article
- Crystal structure of human vinculin Academic Article
- Crystal structure of misoprostol bound to the labor inducer prostaglandin E-2 receptor Academic Article
- Crystal structure of mouse cd1: An mhc-like fold with a large hydrophobic binding groove Academic Article
- Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 Å-resolution Academic Article
- Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser Academic Article
- Crystal structure of soluble md-1 and its interaction with lipid iva Academic Article
- Crystal structure of the 100 kda arsenite oxidase from alcaligenes faecalis in two crystal forms at 1.64 Å and 2.03 Å Academic Article
- Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution Academic Article
- Crystal structure of the Frizzled 4 receptor in a ligand-free state Academic Article
- Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose Academic Article
- Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide Academic Article
- Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran Academic Article
- Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding Academic Article
- Crystal structure of the broadly cross-reactive hiv-1-neutralizing fab x5 and fine mapping of its epitope Academic Article
- Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin a Academic Article
- Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a k(+) channel inhibitor-like fold Academic Article
- Crystal structure of the human 4-1BB/4-1BBL complex Academic Article
- Crystal structure of the human TRPV2 channel ankyrin repeat domain Academic Article
- Crystal structure of the lactose operon repressor and its complexes with DNA and inducer Academic Article
- Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A Academic Article
- Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of camp-dependent protein kinase Academic Article
- Crystal structure of the spindle assembly checkpoint protein Bub3 Academic Article
- Crystal structure of the transcriptional repressor pagr of bacillus anthracis Academic Article
- Crystal structure of the von Willebrand factor modulator botrocetin Academic Article
- Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892 Academic Article
- Crystal structure of tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex Academic Article
- Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases Academic Article
- Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 Å resolution: Self-hydroxylation of phe300 and the pterin-binding site Academic Article
- Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin Academic Article
- Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34 Academic Article
- Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis Academic Article
- Crystal structures of a quorum-quenching antibody Academic Article
- Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP Academic Article
- Crystal structures of apolipoprotein(a) kringle iv37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: Existence of novel and expected binding modes Academic Article
- Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases Academic Article
- Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR Academic Article
- Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates Academic Article
- Crystal structures of human topoisomerase i in covalent and noncovalent complexes with DNA Academic Article
- Crystal structures of leukotriene a(4) hydrolase in complex with captopril and two competitive tight-binding inhibitors Academic Article
- Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands Academic Article
- Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors Academic Article
- Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain Academic Article
- Crystal structures of the free and liganded form of an esterolytic catalytic antibody Academic Article
- Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor Academic Article
- Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake Academic Article
- Crystal structures of transhydrogenase domain i with and without bound nadh Academic Article
- Crystal structures of two I-A(d)-peptide complexes reveal that high affinity can be achieved without large anchor residues Academic Article
- Crystal structures of two rat mhc class ia (rt1-a) molecules that are associated differentially with peptide transporter alleles tap-a and tap-b Academic Article
- Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains Academic Article
- Crystal-structure and mutational analysis of human uracil-DNA glycosylase - structural basis for specificity and catalysis Academic Article
- Crystal-structure of an h-2k(b)-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove Academic Article
- Crystal-structure of cd,zn metallothionein Academic Article
- Crystal-structure of human uracil-DNA glycosylase in complex with a protein inhibitor - protein mimicry of DNA Academic Article
- Crystal-structure of murine cyclophilin-c complexed with immunosuppressive drug cyclosporine-a Academic Article
- Crystal-structure of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f at 2.2 Å resolution Academic Article
- Crystal-structure of the human cell-cycle protein ckshs1 - single-domain fold with similarity to kinase n-lobe domain Academic Article
- Crystal-structures of 2 viral peptides in complex with murine mhc class-i h-2k(b) Academic Article
- Crystal-structures of a schistosomal drug and vaccine target - glutathione-s-transferase from schistosoma-japonica and its complex with the leading antischistosomal drug praziquantel Academic Article
- Crystal-structures of aconitase with isocitrate and nitroisocitrate bound Academic Article
- Crystal-structures of aconitase with trans-aconitate and nitrocitrate bound Academic Article
- Crystallization and preliminary x-ray crystallographic analysis of aart, a designed six-finger zinc-finger peptide, bound to DNA Academic Article
- Crystallographic analysis of 2 site-directed mutants of azotobacter-vinelandii ferredoxin Academic Article
- Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG Academic Article
- Crystallographic fragment-based drug discovery: use of a brominated fragment library targeting HIV protease Academic Article
- Cu,Zn superoxide dismutase structure from a microbial pathogen establishes a class with a conserved dimer interface Academic Article
- Curariform antagonists bind in different orientations to acetylcholine-binding protein Academic Article
- Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins Academic Article
- Custom zinc-finger nucleases for use in human cells Academic Article
- Cyclic and linear oligocarbamate ligands for human thrombin Academic Article
- Cyclin-dependent kinases 5 template: useful for virtual screening Academic Article
- Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation Academic Article
- Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site Academic Article
- Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites Academic Article
- Cys-X scanning for expansion of active-site residues and modulation of catalytic functions in a glutathione transferase Academic Article
- CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis Academic Article
- Cysteine residues are not essential for the catalytic activity of human class Mu glutathione transferase M1a-1a Academic Article
- Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import Academic Article
- Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif Academic Article
- D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain Academic Article
- DNA apurinic-apyrimidinic site binding and excision by endonuclease iv Academic Article
- DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex Academic Article
- DNA binding and nucleotide flipping by the human DNA repair protein agt Academic Article
- DNA loops induced by cooperative binding of transcriptional activator proteins and preinitiation complexes Academic Article
- DNA protein complexes during attachment-site synapsis in Mu DNA transposition Academic Article
- DNA recognition by a σ(54) transcriptional activator from Aquifex aeolicus Academic Article
- DNA sequence-directed nucleosome reconstitution on 5S RNA genes of Xenopus-laevis Academic Article
- DNA-binding proteins in human-serum Academic Article
- DNA-induced alpha-helix capping in conserved linker sequences is a determinant of binding affinity in Cys(2)-His(2) zinc fingers Academic Article
- DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes Academic Article
- De novo computational design of retro-aldol enzymes Academic Article
- Deep cavitands provide organized solvation of reactions Academic Article
- Defining GC-specificity in the minor groove: Side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G Academic Article
- Defining the communication between agonist and coactivator binding in the retinoid X receptor alpha ligand binding domain Academic Article
- Definition of the binding-sites of individual zinc fingers in the transcription factor-IIIA-5S RNA gene-complex Academic Article
- Delineation of spontaneous erythrocyte autoantibody responses of nzb and other strains of mice Academic Article
- Delineation of the peptide binding site of the human galanin receptor Academic Article
- Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: Noncovalent binding coincidental with alkylation Academic Article
- Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit Academic Article
- Demonstration of circulating immune complexes in Sjögren's syndrome Academic Article
- Density functional and electrostatics study of oxidized and reduced ribonucleotide reductase: comparisons with methane monooxygenase Academic Article
- Density functional calculation of pKa values and redox potentials in the bovine Rieske iron-sulfur protein Academic Article
- Density functional studies of oxidized and reduced methane monooxygenase. Optimized geometries and exchange coupling of active site clusters Academic Article
- Density functional theory study of Fe(IV) d-d optical transitions in active-site models of class I ribonucleotide reductase intermediate X with vertical self-consistent reaction field methods Academic Article
- Derivation of a retinoid x receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1h-indol-3-yl)methyl-4-trifluoromethylbenzene Academic Article
- Design and characterization of an active site selective caspase-3 transnitrosating agent Academic Article
- Design and evolution of new catalytic activity with an existing protein scaffold Academic Article
- Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives Academic Article
- Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300 Academic Article
- Design and synthesis of c5 methylated l-arginine analogues as active site probes for nitric oxide synthase Academic Article
- Design and synthesis of novel CCR2 antagonists: Investigation of non-aryl/heteroaryl binding motifs Academic Article
- Design and synthesis of selenazole-containing peptides for cocrystallization with p-glycoprotein Academic Article
- Design of a functional membrane protein by engineering a heme-binding site in glycophorin A Academic Article
- Design of a redox-linked active metal site: manganese bound to bacterial reaction centers at a site resembling that of photosystem II Academic Article
- Design of allele-specific protein methyltransferase inhibitors Academic Article
- Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site Academic Article
- Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d Academic Article
- Design of polydactyl zinc-finger proteins for unique addressing within complex genomes Academic Article
- Design of potent and selective 2-aminobenzimidazole-based p38 alpha MAP kinase inhibitors with excellent in vivo efficacy Academic Article
- Design of stapled DNA-minor-groove-binding molecules with a mutable atom simulated annealing method Academic Article
- Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors Academic Article
- Design, synthesis and evaluation of 2,5-diketopiperazines as inhibitors of the MDM2-p53 interaction Academic Article
- Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors Academic Article
- Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants Academic Article
- Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators Academic Article
- Designing small-molecule switches for protein-protein interactions Academic Article
- Designing transcription factor architectures for drug discovery Academic Article
- Detection of a catalytic antibody species acylated at the active site by electrospray mass spectrometry Academic Article
- Detection of a ternary complex of nf-kappa b and i kappa b alpha with DNA provides insights into how i kappa b alpha removes nf-kappa b from transcription sites Academic Article
- Detection of leucine-independent DNA site occupancy of the yeast Leu3p transcriptional activator in vivo Academic Article
- Determinants of DNA mismatch recognition within the polymerase domain of the klenow fragment Academic Article
- Determinants of cytochrome P4502C8 substrate binding - structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid Academic Article
- Determination and analysis of the 2A structure of copper, zinc superoxide-dismutase Academic Article
- Determination of matrix metalloproteinase activity using biotinylated gelatin Academic Article
- Determination of the 3-dimensional structure of metallothioneins by nuclear-magnetic-resonance spectroscopy in solution Academic Article
- Determination of the NMR solution structure of the cyclophilin-a - cyclosporine-a complex Academic Article
- Determination of the coordination geometry at the heme iron in 3 cytochromes-c from saccharomyces-cerevisiae and from candida-krusei based on individual h-1-NMR assignments for heme-c and the axially coordinated amino-acids Academic Article
- Determination of the nuclear-magnetic-resonance solution structure of the DNA-binding domain (residues 1 to 69) of the 434 repressor and comparison with the x-ray crystal-structure Academic Article
- Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface Academic Article
- Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair Academic Article
- Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor Academic Article
- Development of 5N-bicalutamide, a high-affinity reversible covalent antiandrogen Academic Article
- Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors Academic Article
- Development of Pseudomonas aeruginosa lectin LecA inhibitor by using bivalent galactosides supported on polyproline peptide scaffolds Academic Article
- Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors Academic Article
- Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties Academic Article
- Development of new enzymatic catalysts for peptide-synthesis in aqueous and organic-solvents Academic Article
- Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: Defining the binding mode of 7-oxabicyclo 2.2.1 hept-5-ene scaffold core ligands Academic Article
- Development of sulfonamide photoaffinity inhibitors for probing cellular γ-secretase Academic Article
- Development of thioquinazolinones, allosteric Chk1 kinase inhibitors Academic Article
- Development of zinc finger domains for recognition of the 5 '-ann-3 ' family of DNA sequences and their use in the construction of artificial transcription factors Academic Article
- Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies Academic Article
- Developmentally regulated proteins of plasma-membrane of dictyostelium-discoideum - carbohydrate-binding protein Academic Article
- Dextran as a generally applicable multivalent scaffold for improving immunoglobulin-binding affinities of peptide and peptidomimetic ligands Academic Article
- Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes Academic Article
- Differential and antagonistic effects of v-jun and c-jun Academic Article
- Differential infection of receptor-modified host-cells by receptor-specific influenza-viruses Academic Article
- Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis Academic Article
- Difficulties in determining accurate molecular-motion parameters from proton relaxation enhancement measurements as illustrated by immunoglobulin-g . Gd(iii) system Academic Article
- Dimerization of the klenow fragment of escherichia coli DNA polymerase i is linked to its mode of DNA binding Academic Article
- Direct association between the yeast rad51 and rad54 recombination proteins Academic Article
- Direct evidence for manganese(iii) binding to manganosuperoxide dismutase of escherichia-coli-b Academic Article
- Direct measurement of the aspartic acid 26 pK(a) for reduced Escherichia coli thioredoxin by (13)C NMR Academic Article
- Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance Academic Article
- Direct regulation of clock expression by rev-erb Academic Article
- Directed evolution of a bright near-infrared fluorescent rhodopsin using a synthetic chromophore Academic Article
- Directed evolution of d-sialic acid aldolase to l-3-deoxy-manno-2-octulosonic acid (l-kdo) aldolase Academic Article
- Directed evolution of the TALE N-terminal domain for recognition of all 5' bases Academic Article
- Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model Academic Article
- Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II) Academic Article
- Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I) Academic Article
- Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors Academic Article
- Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering Academic Article
- Discovery of a small molecule insulin mimetic with antidiabetic activity in mice Academic Article
- Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library Academic Article
- Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors Academic Article
- Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design Academic Article
- Discovery of potent and bioavailable GSK-3β inhibitors Academic Article
- Discovery of potent and selective covalent inhibitors of JNK Academic Article
- Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists Academic Article
- Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor's potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations Academic Article
- Discovery of protein phosphatase 2C inhibitors by virtual screening Academic Article
- Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase i7l using homology modeling and covalent docking approaches Academic Article
- Discrete determinants in transfer RNA for editing and aminoacylation Academic Article
- Discriminated selection among viral peptides with the appropriate anchor residues - implications for the size of the cytotoxic t-lymphocyte repertoire and control of viral-infection Academic Article
- Discrimination between steady-state kinetic models of the mechanism of action of yeast glyoxalase I Academic Article
- Dismissal of RNA polymerase II underlies a large ligand-induced enhancer decommissioning program Academic Article
- Disorder-to-order transition of the active site of human class Pi glutathione transferase, GST P1-1 Academic Article
- Dispensable pieces of an aminoacyl tRNA synthetase which activate the catalytic site Academic Article
- Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F Academic Article
- Dissecting the neutralizing antibody-specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors Academic Article
- Dissection of a class II tRNA synthetase: determinants for minihelix recognition are tightly associated with domain for amino acid activation Academic Article
- Dissection of an antibody-catalyzed reaction Academic Article
- Dissociation of clathrin coats coupled to the hydrolysis of atp - role of an uncoating atpase Academic Article
- Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs Academic Article
- Distamycin and penta-N-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving Academic Article
- Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments Academic Article
- Distinct domains of tRNA synthetase recognize the same base pair Academic Article
- Distinct structural attributes regulating von Willebrand factor A1 domain interaction with platelet glycoprotein Ib alpha under flow Academic Article
- Distinguishing binders from false positives by free energy calculations: fragment screening against the flap site of HIV protease Academic Article
- Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes Academic Article
- Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin Academic Article
- Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors Academic Article
- Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2 Academic Article
- Diversified sequences of peptide epitope for same-RNA recognition Academic Article
- Diving into the water: inducible binding conformations for BRD4, TAF1(2), BRD9, and CECR2 bromodomains Academic Article
- Do active site conformations of small ligands correspond to low free-energy solution structures? Academic Article
- Docking molecules by families to increase the diversity of hits in database screens: Computational strategy and experimental evaluation Academic Article
- Docking of 4-oxalocrotonate tautomerase substrates: implications for the catalytic mechanism Academic Article
- Does this have a familiar ring? Academic Article
- Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3 Academic Article
- Domain swapping in inducible nitric-oxide synthase - electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer Academic Article
- Domain-domain communication in a miniature archaebacterial tRNA synthetase Academic Article
- Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling. Mapping with receptor-derived peptides Academic Article
- Double strand binding-single strand incision mechanism for human flap endonuclease: Implications for the superfamily Academic Article
- Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc) Academic Article
- Drug-induced autoimmune disease Academic Article
- Druggable protein interaction sites are more predisposed to surface pocket formation than the rest of the protein surface Academic Article
- Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase Academic Article
- Dual conformations for the hiv-1 gp120 v3 loop in complexes with different neutralizing fabs Academic Article
- Dynamic structure of retinylidene ligand of rhodopsin probed by molecular simulations Academic Article
- Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase Academic Article
- Dynamic visualization of transcription and RNA subcellular localization in zebrafish Academic Article
- Dynamics of lysozyme-saccharide interactions Academic Article
- Dynamics of the dihydrofolate-reductase folate complex - catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features Academic Article
- Dynamin and its partners: A progress report Academic Article
- Dynamin gtpase domain mutants that differentially affect gtp binding, gtp hydrolysis, and clathrin-mediated endocytosis Academic Article
- Dynamin is membrane-active: Lipid insertion is induced by phosphoinositides and phosphatidic acid Academic Article
- E2f-1 induces the stabilization of p53 but blocks p53-mediated transactivation Academic Article
- EF5 is the high-affinity Mg2+ site in ALG-2 Academic Article
- Easybound - a user-friendly approach to nonlinear regression analysis of binding data Academic Article
- Editing by a tRNA synthetase: DNA aptamer-induced translocation and hydrolysis of a misactivated amino acid Academic Article
- Effect of aminoacyl transfer RNA synthetases on H-5 exchange of specific pyrimidines in transfer RNAs Academic Article
- Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase Academic Article
- Effect of disulfide bridge formation on the NMR spectrum of a protein: studies on oxidized and reduced Escherichia coli thioredoxin Academic Article
- Effect of polyanion-resistance on HIV-1 infection Academic Article
- Effect of the peptide moiety of lipid ii on bacterial transglycosylase Academic Article
- Effect of the ubiquitous transcription factors, SP1 and MAZ, on NMDA receptor subunit type 1 (NR1) expression during neuronal differentiation Academic Article
- Effects of abnormal base ionizations on Mg(++) binding to transfer ribonucleic acid as studied by a fluorescent probe Academic Article
- Effects of internal cleavages and mutations in the C-terminal region of NIa protease of turnip mosaic potyvirus on the catalytic activity Academic Article
- Effects of mutations on the partitioning of DNA substrates between the polymerase and 3 '-5 ' exonuclease sites of DNA polymerase i (klenow fragment) Academic Article
- Effects of transition metals on nitric oxide synthase catalysis Academic Article
- Efficient incorporation of unnatural amino acids into proteins in Escherichia coli Academic Article
- Electron and proton transfer in the ba(3) oxidase from thermus thermophilus Academic Article
- Electron microscopy of an alpha-dystroglycan fragment containing receptor sites for lymphocytic choriomeningitis virus and laminin, and use of the receptoid body as a reagent to neutralize virus Academic Article
- Electron paramagnetic resonance study of the active site of copper-substituted human glyoxalase I Academic Article
- Electron tunneling in single crystals of Pseudomonas aeruginosa azurins Academic Article
- Electron-microscopic analysis of modulation of lymphocyte receptor mobility Academic Article
- Electrospray ionization mass-spectrometry as a mechanistic tool - mass of human-leukocyte elastase and a beta-lactam-derived e-i complex Academic Article
- Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c Academic Article
- Electrostatic recognition between superoxide and copper, zinc superoxide-dismutase Academic Article
- Elucidation of the interleukin-15 binding site on its alpha receptor by NMR Academic Article
- Emergence of novel enzyme quasi-species depends on the substrate matrix Academic Article
- Emerging principles for the recognition of peptide antigens by mhc class-i molecules Academic Article
- Empirical entropic contributions in computational docking: evaluation in APS reductase complexes Academic Article
- Encapsidated atom-transfer radical polymerization in Qbeta virus-like nanoparticles Academic Article
- Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme Academic Article
- Energetic contributions and topographical organization of ligand-binding residues of tissue factor Academic Article
- Energetics and affinity of the histone octamer for defined DNA sequences Academic Article
- Energetics of hydrogen bond networks in rna: Hydrogen bonds surrounding g+1 and u42 are the major determinants for the tertiary structure stability of the hairpin ribozyme Academic Article
- Energetics of oxidized and reduced methane monooxygenase active site clusters in the protein environment Academic Article
- Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair Academic Article
- Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection Academic Article
- Engineering a periplasmic binding protein for amino acid sensors with improved binding properties Academic Article
- Engineering of a metal coordinating site into human glutathione transferase M1-1 based on immobilized metal ion affinity chromatography of homologous rat enzymes Academic Article
- Engineering of substrate selectivity for tissue factor.Factor viia complex signaling through protease-activated receptor 2 Academic Article
- Engineering polydactyl zinc-finger transcription factors Academic Article
- Engineering the enantioselectivity of glutathione transferase by combined active-site mutations and chemical modifications Academic Article
- Engineering the melanocortin-4 receptor to control G(s) signaling in vivo Academic Article
- Enhanced binding of rnap ii ctd phosphatase fcp1 to rap74 following ck2 phosphorylation Academic Article
- Enhanced morphine analgesia in mice lacking beta-arrestin 2 Academic Article
- Enhancement of the catalytic properties of human carbonic anhydrase-iii by site-directed mutagenesis Academic Article
- Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway Academic Article
- Enrichment of regulatory signals in conserved non-coding genomic sequence Academic Article
- Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks Academic Article
- Enterotoxin residues determining t-cell receptor v-beta binding-specificity Academic Article
- Enzymatic and chemical approaches for the synthesis of sialyl glycoconjugates Academic Article
- Enzyme structure with two catalytic sites for double-sieve selection of substrate Academic Article
- Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain Academic Article
- Epr studies of the possible binding sites of the cluster n2, semiquinones, and specific inhibitors of the nadh : Quinone oxidoreductase (complex i) Academic Article
- Equilibrium measurements of cognate and noncognate interactions between aminoacyl transfer RNA synthetases and transfer RNA Academic Article
- Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability Academic Article
- Errors from selective disruption of the editing center in a tRNA synthetase Academic Article
- Escherichia coli leader peptidase: production of an active form lacking a requirement for detergent and development of peptide substrates Academic Article
- Escherichia coli ribosomes bind to non-initiator sites of Qβ RNA in the absence of formylmethionyl transfer RNA Academic Article
- Escherichia coli signal peptide peptidase A is a serine-lysine protease with a lysine recruited to the nonconserved amino-terminal domain in the S49 protease family Academic Article
- Escherichia-coli aspartate carbamoyltransferase - the probing of crystal-structure analysis via site-specific mutagenesis Academic Article
- Essential arginine residues in the pyridine nucleotide binding sites of glutathione reductase Academic Article
- Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms Academic Article
- Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants Academic Article
- Evaluating the potential for halogen bonding in the oxyanion hole of ketosteroid isomerase using unnatural amino acid mutagenesis Academic Article
- Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies Academic Article
- Evaluation of c3 receptors on lymphoid cells with different complement sources Academic Article
- Evaluation of functional analogs of CC-1065 and the duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e (C2BI) alkylation subunit Academic Article
- Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor Academic Article
- Evidence for a coordination position available to solute molecules on one of metals at active-center of reduced bovine superoxide-dismutase Academic Article
- Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli Academic Article
- Evidence for an inhibitory effect of the peptide galanin on dopamine release from the rat median eminence Academic Article
- Evidence for breaking domain-domain functional communication in a synthetase-tRNA complex Academic Article
- Evidence for dispensable sequences inserted into a nucleotide fold Academic Article
- Evidence for distinct locations for metal binding sites in two closely related class I tRNA synthetases Academic Article
- Evidence for redox regulation of the transcription factor NtcA, acting both as an activator and a repressor, in the cyanobacterium Anabaena PCC 7120 Academic Article
- Evidence for specific n-terminal galanin fragment binding-sites in the rat-brain Academic Article
- Evidence for the binding of ng-cam to laminin Academic Article
- Evidence from cassette mutagenesis for a structure-function motif in a protein of unknown structure Academic Article
- Evidence that specificity of microhelix charging by a class I tRNA synthetase occurs in the transition state of catalysis Academic Article
- Evidence that the 3' end of a tRNA binds to a site in the adenylate synthesis domain of an aminoacyl-tRNA synthetase Academic Article
- Evolution and mechanism from structures of an adp-ribosylating toxin and nad complex Academic Article
- Evolution of aldolase antibodies in vitro: Correlation of catalytic activity and reaction-based selection Academic Article
- Evolution of class-specific peptides targeting a hot spot of the Galphas subunit Academic Article
- Evolution of glutathione transferases and related enzymes for the protection of cells against electrophiles Academic Article
- Evolution of iron(II)-finger peptides by using a bipyridyl amino acid Academic Article
- Evolutionary analysis of HIV-1 protease inhibitors: methods for design of inhibitors that evade resistance Academic Article
- Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein Academic Article
- Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme Academic Article
- Examination of the transcription factor NtcA-binding motif by in vitro selection of DNA sequences from a random library Academic Article
- Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase Academic Article
- Exon 5 encoded domain is not required for the toxic function of mutant sod1 but essential for the dismutase activity: Identification and characterization of two new sod1 mutations associated with familial amyotrophic lateral sclerosis Academic Article
- Exosite interactions determine the affinity of factor x for the extrinsic xase complex Academic Article
- Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors Academic Article
- Exploring the role of the solvent in the denaturation of a protein - a molecular-dynamics study of the DNA-binding domain of the 434-repressor Academic Article
- Expression and characterization of the flavoprotein subcomplex composed of 50-kda (nqo1) and 25-kda (nqo2) subunits of the proton-translocating nadh-quinone oxidoreductase of paracoccus denitrificans Academic Article
- Extensive amino-acid-sequence homologies between animal lectins Academic Article
- Extent of protein-protein interactions and quasi-equivalence in viral capsids Academic Article
- External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification Academic Article
- Extraordinarily slow binding of guanosine to the Tetrahymena group I ribozyme: Implications for RNA preorganization and function Academic Article
- F-box protein grr1 interacts with phosphorylated targets via the cationic surface of its leucine-rich repeat Academic Article
- Fabrication of an oriented Fc-fused lectin microarray through boronate formation. Academic Article
- Factor Va residues 311-325 represent an activated protein C binding region Academic Article
- Factor XI interacts with the leucine-rich repeats of glycoprotein Ib alpha on the activated platelet Academic Article
- Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling Academic Article
- Fast product formation and slow product release are important features in a hysteretic reaction mechanism of glutathione transferase T2-2 Academic Article
- FeMo cofactor of nitrogenase: a density functional study of states M(N), M(OX), M(R), and M(I) Academic Article
- Features of subunit nuom (nd4) in escherichia coli ndh-1 topology and implication of conserved glu(144) for coupling site 1 Academic Article
- Fibrinolytic system of cultured endothelial cells: regulation by plasminogen activator inhibitor Academic Article
- Fibronectin type III domains engineered to bind CD40L: cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of two complexes Academic Article
- Fine definition of the CXCR4-binding region on the V3 loop of feline immunodeficiency virus surface glycoprotein Academic Article
- Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120 Academic Article
- Fine tuning a molecular motor: The location of alternative domains in the drosophila myosin head Academic Article
- Flavin adenine dinucleotide chromophore charge controls the conformation of cyclobutane pyrimidine dimer photolyase alpha-helices Academic Article
- Flavonol activation defines an unanticipated ligand-binding site in the kinase-rnase domain of ire1 Academic Article
- Flexibility in the ABC transporter MsbA: Alternating access with a twist Academic Article
- Flipping of alkylated DNA damage bridges base and nucleotide excision repair Academic Article
- Fluorescence and nuclear relaxation enhancement studies of the binding of glutathione derivatives to manganese-reconstituted glyoxalase I from human erythrocytes. A model for the catalytic mechanism of the enzyme involving a hydrated metal ion Academic Article
- Fluorescent probes for conformational states of proteins. Iv. The pepsinogen-pepsin conversion Academic Article
- Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing Academic Article
- Folate binding site of flavin-dependent thymidylate synthase Academic Article
- FoldGPCR: Structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A Academic Article
- Formation of a novel four-helix bundle and molecular recognition sites by dimerization of a response regulator phosphotransferase Academic Article
- Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1 Academic Article
- Formation of complement subcomponent c1q immunoglobulin-g complex - thermodynamic and chemical-modification studies Academic Article
- Formation of hybrid concanavalin-a molecules by subunit exchange Academic Article
- Formation of two classes of tRNA synthetases in relation to editing functions and genetic code Academic Article
- Fragment-based screen against HIV protease Academic Article
- From BACE1 inhibitor to multifunctionality of tryptoline and tryptamine triazole derivatives for Alzheimer's disease Academic Article
- From benchmarking HITS-CLIP peak detection programs to a new method for identification of miRNA-binding sites from Ago2-CLIP data Academic Article
- From molecular diversity to catalysis: lessons from the immune system Academic Article
- Full-length archaeal rad51 structure and mutants: Mechanisms for rad51 assembly and control by brca2 Academic Article
- Function independence of microhelix aminoacylation from anticodon binding in a class I tRNA synthetase Academic Article
- Functional activation of integrin αvβ3 in tumor cells expressing membrane-type 1 matrix metalloproteinase Academic Article
- Functional analysis of peptide motif for RNA microhelix binding suggests new family of RNA-binding domains Academic Article
- Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein Academic Article
- Functional analysis suggests unexpected role for conserved active-site residue in enzyme of known structure Academic Article
- Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase Academic Article
- Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering Academic Article
- Functional assembly of a randomly cleaved protein Academic Article
- Functional cavitands: Chemical reactivity in structured environments Academic Article
- Functional cis-heterodimers of N- and R-cadherins Academic Article
- Functional contacts of a transfer RNA synthetase with 2'-hydroxyl groups in the RNA minor groove Academic Article
- Functional dissection of a predicted class-defining motif in a class II tRNA synthetase of unknown structure Academic Article
- Functional dissection of circadian clock- and phytochrome-regulated transcription of the Arabidopsis CAB2 gene Academic Article
- Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3 Academic Article
- Functional importance of the D614G mutation in the SARS-CoV-2 spike protein Academic Article
- Functional interrogation of the kinome using nucleotide acyl phosphates Academic Article
- Functional landscape of SARS-CoV-2 cellular restriction Academic Article
- Functional mimicry of a protein hormone by a peptide agonist: The epo receptor complex at 2.8 Å Academic Article
- Functional modulation of the isolated glycoprotein Ib binding domain of von Willebrand factor expressed in Escherichia coli Academic Article
- Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes Academic Article
- Functional redundancy in the nonspecific RNA binding domain of a class I tRNA synthetase Academic Article
- Functional role for a conserved aspartate in the spo0e signature motif involved in the dephosphorylation of the bacillus subtilis sporulation regulator spo0a Academic Article
- Functional roles for the striatal-enriched transcription factor, bcl11b, in the control of striatal gene expression and transcriptional dysregulation in huntington's disease Academic Article
- Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1. Academic Article
- Functional studies and homology modeling of Msh2-Msh3 predict that mispair recognition involves DNA bending and strand separation Academic Article
- Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface Academic Article
- Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein e2c direct integration of viral DNA into specific sites Academic Article
- GIGANTEA directly activates Flowering Locus T in Arabidopsis thaliana Academic Article
- GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex Academic Article
- GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function Academic Article
- Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B Academic Article
- Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors Academic Article
- Gating mechanisms of acid-sensing ion channels Academic Article
- Gene transcription through activation of G-protein-coupled chemoattractant receptors Academic Article
- Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration Academic Article
- Generation and characterization of specific antibodies directed to the binding domain of adhesive molecules Academic Article
- Generation of a Ni(II) binding site by introduction of a histidine cluster in the structure of human glutathione transferase A1-1 Academic Article
- Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe Academic Article
- Genetic introduction of a diketone-containing amino acid into proteins Academic Article
- Genetic selection of short peptides that support protein oligomerization in vivo Academic Article
- Genetically encoded fragment-based discovery of glycopeptide ligands for carbohydrate-binding proteins Academic Article
- Genome-wide analysis of CREB target genes reveals a core promoter requirement for camp responsiveness Academic Article
- Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues Academic Article
- Genome-wide analysis reveals padi4 cooperates with elk-1 to activate c-fos expression in breast cancer cells Academic Article
- Genome-wide identification of bcl11b gene targets reveals role in brain-derived neurotrophic factor signaling Academic Article
- Genome-wide nucleosome mapping of plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes Academic Article
- Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma Academic Article
- Genomic effects of polyamide/DNA interactions on mRNA expression Academic Article
- Genomic-scale comparison of sequence- and structure-based methods of function prediction: Does structure provide additional insight? Academic Article
- Global structural changes in hepatitis b virus capsids induced by the assembly effector hap1 Academic Article
- Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles Academic Article
- Glutathione transferases in the bioactivation of azathioprine Academic Article
- Glutathione transferases with novel active sites isolated by phage display from a library of random mutants Academic Article
- Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2 Academic Article
- Glycoproteins of plasma-membrane of dictyostelium discoideum during development Academic Article
- Glycosaparaginase from human leukocytes. Inactivation and covalent modification with diazo-oxonorvaline Academic Article
- Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin Academic Article
- Gp120: Biologic aspects of structural features Academic Article
- Gpcr agonist binding revealed by modeling and crystallography Academic Article
- Growth hormone releasing substances: types and their receptors Academic Article
- H-1 NMR-studies at 360 mhz of aromatic amino-acid residues in ferrocytochrome c-552 from euglena-gracilis Academic Article
- H-1 NMR-studies at 360 mhz of methyl-groups in native and chemically modified basic pancreatic trypsin-inhibitor (bpti) Academic Article
- H-1 NMR-studies of heme iron coordination in cytochrome c-552 from euglena-gracilis Academic Article
- H-1, n-15 and c-13 resonance assignments, secondary structure, and the conformation of substrate in the binary folate complex of escherichia-coli dihydrofolate-reductase Academic Article
- H-1, n-15, and c-13 backbone chemical-shift assignments, secondary structure, and magnesium-binding characteristics of the bacillus-subtilis response regulator, spoof, determined by heteronuclear high-resolution NMR Academic Article
- H-1-NMR studies of the coordination geometry at the heme iron and the electronic-structure of the heme group in cytochrome-c-552 from euglena-gracilis Academic Article
- HCV NS5A and IRF9 compete for CypA binding Academic Article
- HCV core residues critical for infectivity are also involved in core-NS5A complex formation Academic Article
- HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors Academic Article
- HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites Academic Article
- HIV-1 mRNA 3' end processing is distinctively regulated by elF3f, CDK11, and splice factor 9G8 Academic Article
- HY5, Circadian Clock-Associated 1, and a cis-element, DET1 dark response element, mediate DET1 regulation of chlorophyll a/b-binding protein 2 expression Academic Article
- Heat stress activates fission yeast Spc1/StyI MAPK by a MEKK-independent mechanism Academic Article
- Helix 11 dynamics is critical for constitutive androstane receptor activity Academic Article
- Hemagglutinin homologue from h17n10 bat influenza virus exhibits divergent receptor-binding and ph-dependent fusion activities Academic Article
- Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins b cell linker protein and slp-76 in lymphocytes Academic Article
- Heme stoichiometry of heterodimeric soluble guanylate cyclase Academic Article
- Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms Academic Article
- Hepatitis C virus E2 envelope glycoprotein core structure Academic Article
- Hepatocyte nuclear factor-4-independent synthesis of coagulation factor vii in breast cancer cells and its inhibition by targeting selective histone acetyltransferases Academic Article
- Heterocyclic derivatives of 2-(3,5-dimethylphenyl)tryptamine as GnRH receptor antagonists Academic Article
- Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation Academic Article
- Hif2 alpha-sp1 interaction mediates a deacetylation-dependent fvii-gene activation under hypoxic conditions in ovarian cancer cells Academic Article
- High affinity targets of protein kinase inhibitors have similar residues at the positions energetically important for binding Academic Article
- High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes Academic Article
- High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA Academic Article
- High resolution structure of the ba3 cytochrome c oxidase from thermus thermophilus in a lipidic environment Academic Article
- High throughput screening of potentially selective mmp-13 exosite inhibitors utilizing a triple-helical fret substrate Academic Article
- High-affinity consensus binding of target RNAs by the STAR/GSG proteins GLS-1, STAR-2 and quaking Academic Article
- High-affinity self-reactive human-antibodies by design and selection - targeting the integrin ligand-binding site Academic Article
- High-resolution capillary zone and gel electrophoresis of structurally similar amphipathic glutathione conjugates based on interaction with beta-cyclodextrins Academic Article
- High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Academic Article
- High-resolution definition of vaccine-elicited b cell responses against the hiv primary receptor binding site Academic Article
- High-resolution functional proteomics by active-site peptide profiling Academic Article
- High-resolution solution structure of bacillus subtilis iia(glc) Academic Article
- High-resolution solution structure of the retinoid X receptor DNA-binding domain Academic Article
- Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters Academic Article
- Highly selective cyclic peptide ligands for NeutrAvidin and avidin identified by phage display Academic Article
- Histones f2a1 and f3 interact reversibly and cooperatively with DNA to form an equimolar complex in chromatin Academic Article
- Hla-dependent expression of testis-organizing h-y antigen by human male cells Academic Article
- Homology between the DNA-binding domain of the gcn4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun Academic Article
- Homology-model-guided site-specific mutagenesis reveals the mechanisms of substrate binding and product-regulation of adenosine kinase from Leishmania donovani Academic Article
- Host-guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents Academic Article
- Hotspot-centric de novo design of protein binders Academic Article
- How do "Zn2 cys6" proteins distinguish between similar upstream activation sites? Comparison of the DNA-binding specificity of the GAL4 protein in vitro and in vivo Academic Article
- How does the GAL4 transcription factor recognize the appropriate DNA binding sites in vivo? Academic Article
- HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis Academic Article
- Human IL-1-beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA Academic Article
- Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses Academic Article
- Human antibody effector function Academic Article
- Human ckshs2 atomic-structure - a role for its hexameric assembly in cell-cycle control Academic Article
- Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues Academic Article
- Human dutp pyrophosphatase: Uracil recognition by a beta hairpin and active sites formed by three separate subunits Academic Article
- Human fc-gamma-ri and fc-gamma-rii interact with distinct but overlapping sites on human-igg Academic Article
- Human glutathione transferase a4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products Academic Article
- Human immunodeficiency virus envelope (gp120) binding to dc-sign and primary dendritic cells is carbohydrate dependent but does not involve 2g12 or cyanovirin binding sites: Implications for structural analyses of gp120-dc-sign binding Academic Article
- Human immunodeficiency virus matrix tyrosine phosphorylation: Characterization of the kinase and its substrate requirements Academic Article
- Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein e2c can bias integration of viral DNA into a predetermined chromosomal region in human cells Academic Article
- Human mitochondrial manganese superoxide dismutase polymorphic variant ile58thr reduces activity by destabilizing the tetrameric interface Academic Article
- Human neural cell adhesion molecule l1 and rat homologue nile are ligands for integrin alpha(v)beta(3) Academic Article
- Human rhinovirus capsid dynamics is controlled by canyon flexibility Academic Article
- Hybrid cytochromes P-450 identify a substrate binding domain in P-450IIC5 and P-450IIC4 Academic Article
- Hybridization of alpha class subunits generating a functional glutathione transferase A1-4 heterodimer Academic Article
- Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine Academic Article
- Hydrogen-deuterium exchange strategy for delineation of contact sites in protein complexes Academic Article
- Hydrogen/deuterium-exchange (H/D-Ex) of PPAR gamma LBD in the presence of various modulators Academic Article
- Hydrolytic antibodies: variations on a theme Academic Article
- Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker Academic Article
- Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis Academic Article
- Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies Academic Article
- Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif Academic Article
- Hypoxia-inducible factor 1α (HIF-1α)-mediated hypoxia increases BACE1 expression and β-amyloid generation Academic Article
- Identical components of yeast transcription factor IIIB are required and sufficient for transcription of TATA box-containing and TATA-less genes Academic Article
- Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III Academic Article
- Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways Academic Article
- Identification and cross-species comparison of canine osteoarthritic gene regulatory cis-elements Academic Article
- Identification and design of p53-derived HLA-A2-binding peptides with increased CTL immunogenicity Academic Article
- Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA Academic Article
- Identification and structure-activity relationships of a new series of Melanocortin-4 receptor antagonists Academic Article
- Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the α2δ-1 subunit of voltage gated calcium channel Academic Article
- Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase Academic Article
- Identification of 50S components neighboring 23S rRNA nucleotides A2448 and U2604 within the peptidyl transferase center of Escherichia coli ribosomes Academic Article
- Identification of GABA(c) receptor protein homeostasis network components from three tandem mass spectrometry proteomics approaches Academic Article
- Identification of Gal4 activation domain-binding proteins in the 26S proteasome by periodate-triggered cross-linking Academic Article
- Identification of Phe(313) of the gonadotropin-releasing hormone (GnRH) receptor as a site critical for the binding of nonpeptide GnRH antagonists Academic Article
- Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB Academic Article
- Identification of a lipid-a binding-site in the acute phase reactant lipopolysaccharide binding-protein Academic Article
- Identification of a minimal domain of 5 S ribosomal RNA sufficient for high affinity interactions with the RNA-specific zinc fingers of transcription factor IIIA Academic Article
- Identification of a new cryptochrome class: Structure, function, and evolution Academic Article
- Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein Academic Article
- Identification of a novel integrin binding-site in fibronectin - differential utilization by beta-3 integrins Academic Article
- Identification of a p53 binding-site in the human retinoblastoma susceptibility gene promoter Academic Article
- Identification of a putative steroidogenic factor-i response element in the dax-1 promoter Academic Article
- Identification of a regulatory domain of the interleukin-6 receptor Academic Article
- Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding Academic Article
- Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT) Academic Article
- Identification of an N-formyl peptide receptor ligand binding domain by a gain-of-function approach Academic Article
- Identification of an epitope in the major envelope protein of epstein-barr virus that mediates viral binding to the lymphocyte-b ebv receptor (cr-2) Academic Article
- Identification of an epitope of alpha-enolase (a candidate plasminogen receptor) by phage display Academic Article
- Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors Academic Article
- Identification of covalent bromodomain binders through DNA display of small molecules Academic Article
- Identification of critical active-site residues in the multifunctional human DNA-repair enzyme hap1 Academic Article
- Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin. A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib Academic Article
- Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays Academic Article
- Identification of endogenous ligands bound to bacterially expressed human and E. coli dihydrofolate reductase by 2D NMR Academic Article
- Identification of histidine and methionine residues in the active site of the human uterine progesterone receptor with the affinity labels 11 alpha- and 16 alpha-(bromoacetoxy)progesterone Academic Article
- Identification of inhibitors of the E. coli chaperone SurA using in silico and in vitro techniques Academic Article
- Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor Academic Article
- Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility Academic Article
- Identification of novel binding elements and gene targets for the homeodomain protein BARX2 Academic Article
- Identification of novel macrocyclic peptidase substrates via on-bead enzymatic cyclization Academic Article
- Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds Academic Article
- Identification of potent Yes1 kinase inhibitors using a library screening approach Academic Article
- Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta Academic Article
- Identification of residues 413-433 of plasma protein S as essential for binding to C4b-binding protein Academic Article
- Identification of residues in TIP47 essential for Rab9 binding Academic Article
- Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay Academic Article
- Identification of specific binding-proteins for a nuclear location sequence Academic Article
- Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase Academic Article
- Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor viia Academic Article
- Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis Academic Article
- Identification of the dicyclohexylcarbodiimide-binding subunit of nadh-ubiquinone oxidoreductase (complex-i) Academic Article
- Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate Academic Article
- Identification of the nadh-binding subunit of energy-transducing nadh-quinone oxidoreductase (ndh-1) of thermus thermophilus hb-8 Academic Article
- Identification of the nadh-binding subunit of nadh-ubiquinone oxidoreductase of paracoccus-denitrificans Academic Article
- Identification of the regions involved in DNA binding by the mouse PEBP2alpha protein Academic Article
- Identification of the zinc ligands in cobalamin-independent methionine synthase (MetE) from Escherichia coli Academic Article
- Identification of transcription factor binding sites in the human genome sequence Academic Article
- Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides Academic Article
- Idiographic representation of conserved domain of a class II tRNA synthetase of unknown structure Academic Article
- Imidazole-imidazole pair as a minor groove recognition motif for T:G mismatched base pairs Academic Article
- Immune versus natural selection: Antibody aldolases with enzymic rates but broader scope Academic Article
- Immunological and binding studies on chloroform--methanol extracts from electroplax of Torpedo marmorata and from rat brain cortex. Comparison of the material solubilized by organic solvents with the receptor proteins solubilized by detergents Academic Article
- Immunological memory to hyperphosphorylated tau in asymptomatic individuals Academic Article
- Immunological mimicry by a monoclonal-antibody of the tricyclic anti-depressants binding-site on muscarinic acetylcholine-receptors Academic Article
- Immunological origins of binding and catalysis in a Diels-Alderase antibody Academic Article
- Immunoregulatory plasma low-density lipoprotein - the biologic activity and receptor-binding specificity is independent of neutral lipids Academic Article
- Impairment of dynamin's gap domain stimulates receptor-mediated endocytosis Academic Article
- Implications for the domain arrangement of axonin-1 derived from the mapping of its NgCAM binding site Academic Article
- Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor Academic Article
- Importance of a conserved residue, aspartate-162, for the function of escherichia-coli aspartate transcarbamoylase Academic Article
- Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs Academic Article
- Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation Academic Article
- Importance of minor groove binding zinc fingers within the transcription factor IIIA-DNA complex Academic Article
- Importin beta contains a cooh-terminal nucleoporin binding region important for nuclear transport Academic Article
- Improved design of an antigen with enhanced specificity for the broadly hiv-neutralizing antibody b12 Academic Article
- Improved identification of SUMO attachment sites using C-terminal SUMO mutants and tailored protease digestion strategies Academic Article
- Improved model building and assessment of the Calcium-sensing receptor transmembrane domain Academic Article
- Improving the serum stability of site-specific antibody conjugates with sulfone linkers Academic Article
- In different organisms, the mode of interaction between two signaling proteins is not necessarily conserved Academic Article
- In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the opca outer membrane adhesin Academic Article
- In silico screening against wild-type and mutant Plasmodium falciparum dihydrofolate reductase Academic Article
- In situ selection of lead compounds by click chemistry: Target-guided optimization of acetylcholinesterase inhibitors Academic Article
- In vitro analysis of nuclear transport mediated by the c-terminal shuttle domain of tap Academic Article
- In vitro selection of nucleic acids and proteins: what are we learning? Academic Article
- In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for icam-1 provides new insights into gene regulation Academic Article
- In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase Academic Article
- In vivo, in vitro, and molecular aspects of interleukin-8 and the interleukin-8 receptors Academic Article
- In-line separation by capillary electrophoresis prior to analysis by top-down mass spectrometry enables sensitive characterization of protein complexes Academic Article
- In-vitro evolution of a neutralizing human-antibody to human-immunodeficiency-virus type-1 to enhance affinity and broaden strain cross-reactivity Academic Article
- Inactivation of beta-adrenergic receptors by n-ethylmaleimide - permissive role of beta-adrenergic agents in relation to adenylate-cyclase activation Academic Article
- Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A Academic Article
- Increasing protein stability using a rational approach combining sequence homology and structural alignment: stabilizing the WW domain Academic Article
- Independent assembly and secretion of a dimeric adhesive domain of von Willebrand factor containing the glycoprotein Ib-binding site Academic Article
- Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody Academic Article
- Individual h-1-NMR assignments for the heme groups and the axially bound amino-acids and determination of the coordination geometry at the heme iron in a mixture of 2 isocytochromes-c-551 from rhodopseudomonas-gelatinosa Academic Article
- Inducible nitric oxide synthase: Role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction Academic Article
- Influence of cargo size on ran and energy requirements for nuclear protein import Academic Article
- Influence of cofactor binding and active site occupancy on the conformation of the macromolecular substrate exosite of factor viia Academic Article
- Influence of electronic and structural effects on the oxidative behavior of nickel porphyrins Academic Article
- Influence of novel cd4 binding-defective hiv-1 envelope glycoprotein immunogens on neutralizing antibody and t-cell responses in nonhuman primates Academic Article
- Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein Academic Article
- Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity Academic Article
- Inherent protein structural flexibility at the RNA-binding interface of L30e Academic Article
- Inhibiting transthyretin amyloid fibril formation via protein stabilization Academic Article
- Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors Academic Article
- Inhibition by capsaicin of nadh-quinone oxidoreductases is correlated with the presence of energy-coupling site-1 in various organisms Academic Article
- Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-kappa B, and DNA by a designed DNA-binding ligand Academic Article
- Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes Academic Article
- Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands Academic Article
- Inhibition of a viral enzyme by a small-molecule dimer disruptor Academic Article
- Inhibition of cytochrome p-450 activity in rat liver microsomes by the naturally occurring flavonoid, quercetin Academic Article
- Inhibition of glutathione reductase by interaction of 2, 4, 6-trinitrobenzenesulfonate with the active-site dithiol Academic Article
- Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site Academic Article
- Inhibition of proteolysis and other posttranslational modifications with substrate-targeted inhibitors Academic Article
- Inhibitor focusing: direct selection of drug targets from proteomes using activity-based probes Academic Article
- Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase Academic Article
- Inscribing the perimeter of the PagP hydrocarbon ruler by site-specific chemical alkylation Academic Article
- Insertion of new sequences into the catalytic domain of an enzyme Academic Article
- Insight into the sporulation phosphorelay: Crystal structure of the sensor domain of Bacillus subtilis histidine kinase, KinD Academic Article
- Insights into PPAR gamma from structures with endogenous and covalently bound ligands Academic Article
- Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9 Å resolution Academic Article
- Insights into the mode of action of a putative zinc transporter czrb in thermus thermophilus Academic Article
- Insights into the nature of DNA binding of AbrB-like transcription factors Academic Article
- Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation Academic Article
- Integrating folding kinetics and protein function: biphasic kinetics and dual binding specificity in a WW domain Academic Article
- Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins Academic Article
- Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage Academic Article
- Interaction between the androgen receptor and a segment of its corepressor SHP Academic Article
- Interaction between the cell-cycle-control proteins p34cdc2 and p9ckshs2 - evidence for 2 cooperative binding domains in p9ckshs2 Academic Article
- Interaction interface of human flap endonuclease-1 with its DNA substrates Academic Article
- Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function Academic Article
- Interaction of DNA with the klenow fragment of DNA-polymerase-i studied by time-resolved fluorescence spectroscopy Academic Article
- Interaction of Lp(a) with plasminogen binding sites on cells Academic Article
- Interaction of colchicine and some related alkaloids with rat-brain tubulin Academic Article
- Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II Academic Article
- Interaction of epothilone analogs with the paclitaxel binding site: Relationship between binding affinity, microtubule stabilization, and cytotoxicity Academic Article
- Interaction of human hemoglobin with adenine nucleotides Academic Article
- Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites Academic Article
- Interaction of lysozyme with alpha-N-acetyl-D-glucosamine Academic Article
- Interaction of manganese with fragments, complementary fragment recombinations, and whole molecules of yeast phenylalanine specific transfer RNA Academic Article
- Interaction of polyamines with fragments and whole molecules of yeast phenylalanine-specific transfer RNA Academic Article
- Interaction of the RNA-binding fingers of Xenopus transcription factor IIIA with specific regions of 5-S ribosomal-RNA Academic Article
- Interaction of the mediator head module with RNA polymerase II Academic Article
- Interaction of the peroxisome proliferator-activated receptor-alpha with the retinoid-X receptor-alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter Academic Article
- Interaction of the taz1 domain of the creb-binding protein with the activation domain of cited2 - regulation by competition between intrinsically unstructured ligands for non-identical binding sites Academic Article
- Interaction of urea with an unfolded protein - the DNA-binding domain of the 434-repressor Academic Article
- Interaction of xenopus TFIIIC with the TFIIIA.5-S RNA gene-complex Academic Article
- Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin Academic Article
- Interactions and inhibition of blood-coagulation factor-Va involving residues 311-325 of activated protein-C Academic Article
- Interactions of Qβ replicase with Qβ RNA Academic Article
- Interactions of active-site residues and catalytic activity of human carbonic anhydrase III Academic Article
- Interactions of bovine neurophysin-II with oxytocin and 8-lysine vasopressin - high-resolution proton nuclear magnetic-resonance spectroscopy studies Academic Article
- Interactions of soluble recombinant integrin alpha v beta 5 with human adenoviruses Academic Article
- Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression Academic Article
- Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta (C/EBP beta) Academic Article
- Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue Academic Article
- Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin Academic Article
- Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells Academic Article
- Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase Academic Article
- Investigation of the PDZ domain ligand binding site using chemically modified peptides Academic Article
- Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters Academic Article
- Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein Academic Article
- Involvement of an active-site Zn2+ ligand mechanism of human glyoxalase I Academic Article
- Iron superoxide-dismutase from escherichia-coli at 3.1-a resolution - a structure unlike that of copper-zinc protein at both monomer and dimer levels Academic Article
- Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? Academic Article
- Isoform-selective and stereoselective inhibition of hypoxia inducible factor-2 Academic Article
- Isolated RNA binding domain of a class I tRNA synthetase Academic Article
- Isolation and characterization of a collagen binding domain in human von Willebrand factor Academic Article
- Isolation and characterization of maclura pomifera (mp) lectin Academic Article
- Isolation and characterization of the DNA and protein binding activities of adenovirus core protein V Academic Article
- Isolation and functional characterization of the von Willebrand factor-binding domain located between residues His1-Arg293 of the alpha-chain of glycoprotein Ib Academic Article
- Isolation and sequence-specific DNA-binding of the antennapedia homeodomain Academic Article
- Isolation of lectins of different specificities on a single affinity adsorbent Academic Article
- Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model Academic Article
- Isolation of the von Willebrand factor domain interacting with platelet glycoprotein Ib, heparin, and collagen and characterization of its three distinct functional sites Academic Article
- Isothermal titration calorimetry and surface plasmon resonance allow quantifying substrate binding to different binding sites of Bacillus subtilis xylanase Academic Article
- Isotope labeling of free and aminoacyl transfer RNA synthetase-bound transfer RNA Academic Article
- Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress Academic Article
- Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein tpr Academic Article
- Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP Academic Article
- Kinetic analysis of integrin-dependent cell adhesion on vitronectin: the inhibitory potential of plasminogen activator inhibitor-1 and RGD peptides Academic Article
- Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase Academic Article
- Kinetic analysis of the interaction between type 1 plasminogen activator inhibitor and vitronectin and evidence that the bovine inhibitor binds to a thrombin-derived amino-terminal fragment of bovine vitronectin Academic Article
- Kinetic analysis of the interaction between vitronectin and the urokinase receptor Academic Article
- Kinetic and spectroscopic evidence for three actomyosin : Adp states in smooth muscle Academic Article
- Kinetic and stoichiometric characterisation of streptavidin-binding aptamers Academic Article
- Kinetic independence of the subunits of cytosolic glutathione transferase from the rat Academic Article
- Kinetic intermediates trapped by native interactions in RNA folding Academic Article
- Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3 alpha 1 Academic Article
- Kinetic mechanism of RGS9-1 potentiation by R9AP Academic Article
- Kinetics and mechanisms of reduction of cu(ii) and fe(iii) complexes by soybean leghemoglobin-alpha Academic Article
- Kinetics and mechanisms of the oxidation of myoglobin by fe(iii) and cu(ii) complexes Academic Article
- Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of udp-glcnac enolpyruvoyl transferase by the antibiotic fosfomycin Academic Article
- Kinomics-structural biology and chemogenomics of kinase inhibitors and targets Academic Article
- Kinomics: Characterizing the therapeutically validated kinase space Academic Article
- L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding Academic Article
- L-a virus at 3.4 Å resolution reveals particle architecture and mrna decapping mechanism Academic Article
- Lack of complex i activity in human cells carrying a mutation in mtdna-encoded nd4 subunit is corrected by the saccharomyces cerevisiae nadh-quinone oxidoreductase (ndi1) gene Academic Article
- Lactose binding induces opposing dynamics changes in human galectins revealed by NMR-based hydrogen-deuterium exchange Academic Article
- Large conformational changes in the maturation of a simple rna virus, nudaurelia capensis omega virus (n omega v) Academic Article
- Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response Academic Article
- Leu5enkephalin-encoding sequences are targets for a specific DNA-binding factor. Academic Article
- Leu628 of the kix domain of cbp is a key residue for the interaction with the mll transactivation domain Academic Article
- Ligand accessibility to the HIV-1 Env co-receptor binding site can occur prior to CD4 engagement and is independent of viral tier category Academic Article
- Ligand activation of ERRα by cholesterol mediates statin and bisphosphonate effects Academic Article
- Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues Academic Article
- Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening Academic Article
- Ligand-dependent perturbation of the conformational ensemble for the GPCR beta(2) adrenergic receptor revealed by HDX Academic Article
- Ligand-guided receptor optimization Academic Article
- Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor Academic Article
- Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation Academic Article
- Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms Academic Article
- Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate Academic Article
- Like-acetylglucosaminyltransferase (large)-dependent modification of dystroglycan at thr-317/319 is required for laminin binding and arenavirus infection Academic Article
- Linear and cyclic N-terminal galanin fragments and analogs as ligands at the hypothalamic galanin receptor Academic Article
- Linear combinations of docking affinities explain quantitative differences in RTK signaling Academic Article
- Linking folding and binding Academic Article
- Lipid binding promotes oligomerization and focal adhesion activity of vinculin Academic Article
- Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells - regulation by egr-1, c-jun, and nf-kappa b transcription factors Academic Article
- Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2 Academic Article
- Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in thp-1 monocytic cells requires both activator protein-1 and nuclear factor-kappa-b binding-sites Academic Article
- Lipoprotein complex of equine lysozyme with oleic acid (eloa) interactions with the plasma membrane of live cells Academic Article
- Liver x receptor-retinoid x receptor (lxr-rxr) heterodimer cistrome reveals coordination of lxr and ap1 signaling in keratinocytes Academic Article
- Local folding coupled to RNA binding in the yeast ribosomal protein L30 Academic Article
- Localization of carbohydrate attachment sites and disulfide bridges in limulus alpha(2)-macroglobulin - evidence for two forms differing primarily in their bait region sequences Academic Article
- Localization of membrane permeabilization and receptor binding sites on the vp4 hemagglutinin of rotavirus: Implications for cell entry Academic Article
- Localization of sites of interaction between p23 and hsp90 in solution Academic Article
- Localization of the binding-site for the human high-affinity fc receptor on igg Academic Article
- Localization of the heme binding region in soluble guanylate cyclase Academic Article
- Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity Academic Article
- Location of high-affinity metal-binding sites in the profile structure of the Ca+2-ATPase in the sarcoplasmic-reticulum by resonance x-ray-diffraction Academic Article
- Location of the saccharide binding site of concanavalin a Academic Article
- Location, degree, and direction of DNA bending associated with the Hin recombinational enhancer sequence and Fis-enhancer complex Academic Article
- Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase Academic Article
- Lung Kruppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase Academic Article
- Lysis of human cultured lymphoblastoid cells by cell-induced activation of properdin pathway Academic Article
- M-15: high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus, and spinal cord Academic Article
- MDB: The metalloprotein database and browser at The Scripps Research Institute Academic Article
- Mafa has strong cell transforming ability but is a weak transactivator Academic Article
- Magnetic-properties of cobalt substituted bovine superoxide-dismutase derivatives Academic Article
- Maintaining genetic code through adaptations of tRNA synthetases to taxonomic domains Academic Article
- Major anticodon-binding region missing from an archaebacterial tRNA synthetase Academic Article
- Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape Academic Article
- Malachite green mediates homodimerization of antibody VL domains to form a fluorescent ternary complex with singular symmetric interfaces Academic Article
- Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation Academic Article
- Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity Academic Article
- Manipulation of thrombin exosite I, by ligand-directed covalent modification Academic Article
- Map2 and tau bind longitudinally along the outer ridges of microtubule protofilaments Academic Article
- Map2c, but not tau, binds via its microtubule binding and bundles f-actin domain Academic Article
- Mapkk-independent activation of p38 alpha mediated by tab1-dependent autophosphorylation of p38 alpha Academic Article
- Mapping a common interaction site used by plasmodium falciparum duffy binding-like domains to bind diverse host receptors Academic Article
- Mapping binding residues in the Plasmodium vivax domain that binds Duffy antigen during red cell invasion Academic Article
- Mapping determinants of the substrate selectivities of P450 enzymes by site-directed mutagenesis Academic Article
- Mapping enzyme active sites in complex proteomes Academic Article
- Mapping interactions between the rna chaperone fino and its rna targets Academic Article
- Mapping of distinct von Willebrand factor domains interacting with platelet GPIb and GPIIb/IIIa and with collagen using monoclonal antibodies Academic Article
- Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, hpr and iia(glc) Academic Article
- Mapping of the cxcr4 binding site within variable region 3 of the feline immunodeficiency virus surface glycoprotein Academic Article
- Mapping the binding site of BMS-708163 on γ-secretase with cleavable photoprobes Academic Article
- Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo Academic Article
- Mapping the interactions of the p53 transactivation domain with the kix domain of cbp Academic Article
- Mapping the transition state of the WW domain beta-sheet Academic Article
- Maxamycins: Durable Antibiotics Derived by Rational Redesign of Vancomycin Academic Article
- Measles virus recognizes its receptor, cd46, via two distinct binding domains within scr1-2 Academic Article
- Measles-virus and c3 binding-sites are distinct on membrane cofactor protein (cd46) Academic Article
- Mechanism and atomic structure of superoxide dismutase Academic Article
- Mechanism of Action of an Imidopiperidine Inhibitor of Human Polynucleotide Kinase/Phosphatase Academic Article
- Mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia: Role of the nucleotide positioning loop Academic Article
- Mechanism of binding site conformational switching in the CD44-hyaluronan protein-carbohydrate binding interaction Academic Article
- Mechanism of drug inhibition and drug resistance of influenza A M2 channel Academic Article
- Mechanism of human alpha-1,3-fucosyltransferase v: Glycosidic cleavage occurs prior to nucleophilic attack Academic Article
- Mechanism of microtubule stabilization by doublecortin Academic Article
- Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01 Academic Article
- Mechanism of thioflavin T binding to amyloid fibrils Academic Article
- Mechanism-based phage display selection of active-site mutants of human glutathione transferase A1-1 catalyzing SNAr reactions Academic Article
- Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate Academic Article
- Mechanisms of spectral tuning in blue cone visual pigments. Visible and raman spectroscopy of blue-shifted rhodopsin mutants Academic Article
- Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides Academic Article
- Mechanistic implications of pseudo zero order kinetics in kinetic resolutions Academic Article
- Mechanistic studies of beta-arylsulfotransferase iv Academic Article
- Mediator structural conservation and implications for the regulation mechanism Academic Article
- Membrane-associated DNA in the cytoplasm of diploid human lymphocytes Academic Article
- Merlin, the product of the Nf2 tumor suppressor gene, the p21-activated is an inhibitor of kinase, Pak1 Academic Article
- Metal stoichiometry and functional studies of the diphtheria toxin repressor Academic Article
- Metal-binding site in a class I tRNA synthetase localized to a cysteine cluster inserted into nucleotide-binding fold Academic Article
- Metal-binding sites in proteins Academic Article
- Metalloantibody design Academic Article
- Methionine ligand interaction in a blue copper protein characterized by site-selective infrared spectroscopy Academic Article
- Microarray platform for profiling enzyme activities in complex proteomes Academic Article
- Microbial glycan microarrays define key features of host-microbial interactions Academic Article
- Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features Academic Article
- Minor groove DNA-protein contacts upstream of a tRNA gene detected with a synthetic DNA binding ligand Academic Article
- Minor groove recognition of the critical acceptor helix base pair by an appended module of a class II tRNA synthetase Academic Article
- Misactivated amino acids translocate at similar rates across surface of a tRNA synthetase Academic Article
- Model building and refinement of a natively glycosylated HIV-1 Env protein by high-resolution cryoelectron microscopy Academic Article
- Model of the alpha L beta 2 integrin I-domain/ICAM-1 DI interface suggests that subtle changes in loop orientation determine ligand specificity Academic Article
- Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues Academic Article
- Models of the serine-protease domain of the human antithrombotic plasma factor-activated protein-C and its zymogen Academic Article
- Modes of peptide binding in G protein-coupled receptors Academic Article
- Modification of the binding site for pyridine nucleotides of glutathione reductase by 2,3-butanedione Academic Article
- Modular arrangement of functional domains along the sequence of an aminoacyl tRNA synthetase Academic Article
- Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ib-alpha Academic Article
- Modulation of lymphocyte receptor mobility by locally bound concanavalin-a Academic Article
- Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase Academic Article
- Molecular analysis of the interaction of lcmv with its cellular receptor alpha-dystroglycan Academic Article
- Molecular basis for p38 protein kinase inhibitor specificity Academic Article
- Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity Academic Article
- Molecular basis for the generation in pigs of influenza a viruses with pandemic potential Academic Article
- Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta Academic Article
- Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition Academic Article
- Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C Academic Article
- Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions Academic Article
- Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein Academic Article
- Molecular cloning of Limulus alpha 2-macroglobulin Academic Article
- Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P Academic Article
- Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd Academic Article
- Molecular determinants of lxr alpha agonism Academic Article
- Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3 Academic Article
- Molecular docking programs successfully predict the binding of a beta-lactamase inhibitory protein to TEM-1 beta-lactamase Academic Article
- Molecular editing of kinase-targeting resorcylic acid lactones (RAL): Fluoroenone RAL Academic Article
- Molecular evolution of antibody cross-reactivity for two subtypes of type a botulinum neurotoxin Academic Article
- Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120 Academic Article
- Molecular mechanism for the umami taste synergism Academic Article
- Molecular mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia - roles of conserved active site residues Academic Article
- Molecular mechanism of the sweet taste enhancers Academic Article
- Molecular modeling and crystal structure of ERK2-hypothemycin complexes Academic Article
- Molecular probes of spermatozoan structures Academic Article
- Molecular recognition and binding free energy calculations in drug development Academic Article
- Molecular recognition by the Candida albicans group I intron: tertiary interactions with an imino G.A pair facilitate binding of the 5' exon and lower the KM for guanosine Academic Article
- Molecular recognition in signal transduction: The interaction surfaces of the spo0f response regulator with its cognate phosphorelay proteins revealed by alanine scanning mutagenesis Academic Article
- Molecular recognition of 6 '-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches Academic Article
- Molecular recognition of insulin by a synthetic receptor Academic Article
- Molecular recognition: model studies with convergent functional groups Academic Article
- Molecular-cloning of the cdna-encoding the epstein-barr virus/c3d receptor (complement receptor type-2) of human lymphocytes-b Academic Article
- Molecular-genetic and protein chemical characterization of the cytochrome ba(3) from thermus-thermophilus hb8 Academic Article
- Molecular-structure of f-actin and location of surface binding-sites Academic Article
- Monoclonal antibodies against receptor-induced binding sites detect cell-bound plasminogen in blood Academic Article
- Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen Academic Article
- Monolayers of derivatized poly(L-lysine)-grafted poly(ethylene glycol) on metal oxides as a class of biomolecular interfaces Academic Article
- Monovalet derivatives of concanavalin-a Academic Article
- Motor domains of kinesin and ncd interact with microtubule protofilaments with the same binding geometry Academic Article
- Multi-substrate-activity space and quasi-species in enzyme evolution: Ohno's dilemma, promiscuity and functional orthogonality Academic Article
- Multifrequency epr evidence for a binuclear cu-a center in cytochrome-c-oxidase - studies with a cu-63-enriched and cu-65-enriched, soluble domain of the cytochrome-ba(3) subunit-ii from thermus-thermophilus Academic Article
- Multiple adenovirus serotypes use alpha-v integrins for infection Academic Article
- Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors Academic Article
- Multiple epitope specificity of monoclonal antibodies to a single synthetic peptide: use in the characterization of the GP IIb-IIIa binding domain of von Willebrand factor Academic Article
- Multiple replacements of glutamine 143 in human manganese superoxide dismutase: Effects on structure, stability, and catalysis Academic Article
- Multiple sites on IL-8 responsible for binding to alpha and beta IL-8 receptors Academic Article
- Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1 Academic Article
- Mus81-Eme1 are essential components of a Holliday junction resolvase Academic Article
- Muscarinic acetylcholine receptor from rat brain. Partial purification and characterization Academic Article
- Mutagenesis and ligand modification studies on galanin binding to its GTP-binding-protein-coupled receptor GalR1 Academic Article
- Mutagenesis of residue 157 in the active site of human glyoxalase I Academic Article
- Mutagenesis study on human galanin receptor GalR1 reveals domains involved in ligand binding Academic Article
- Mutation of an active site residue in escherichia coli uracil-DNA glycosylase: Effect on DNA binding, uracil inhibition and catalysis Academic Article
- Mutation of an evolutionarily conserved tyrosine residue in the active site of a human class Alpha glutathione transferase Academic Article
- Mutational activation of c-raf-1 and definition of the minimal transforming sequence Academic Article
- Mutational analysis of 48G7 reveals that somatic hypermutation affects both antibody stability and binding affinity Academic Article
- Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay Academic Article
- Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine Academic Article
- Mutational analysis of the active-site residues crucial for catalytic activity of adenosine kinase from Leishmania donovani Academic Article
- Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase Academic Article
- Mutational and biophysical studies suggest rc3/neurogranin regulates calmodulin availability Academic Article
- Mutational isolation of a sieve for editing in a transfer RNA synthetase Academic Article
- Mutational mapping of functional residues in tissue factor - identification of factor-vii recognition determinants in both structural modules of the predicted cytokine receptor homology domain Academic Article
- Mutational separation of two pathways for editing by a class I tRNA synthetase Academic Article
- Mutations in the G-domain of elongation factor G from thermus thermophilus affect both its interaction with GTP and fusidic acid Academic Article
- Mycoplasma-arthritidis mitogen -V-beta engaged in mice, rats, and humans, and requirement of HLA-DR-alpha for presentation Academic Article
- N-(arylacetyl)-biphenylalanines as potent vla-4 antagonists Academic Article
- N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability Academic Article
- N-terminal domain of Borna disease virus g (p56) protein is sufficient for virus receptor recognition and cell entry Academic Article
- N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization Academic Article
- N-terminally elongated fragments of galanin(1-16) inhibit insulin secretion from isolated mouse islets Academic Article
- N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase Academic Article
- N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase Academic Article
- NF kappa B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Academic Article
- NMR Based SARS-CoV-2 Antibody Screening Academic Article
- NMR and computer modeling studies of the conformations of glutathione derivatives at the active site of glyoxalase I Academic Article
- NMR and molecular dynamics studies of the hydration of a zinc finger-DNA complex Academic Article
- NMR assignment of the spinophilin PDZ domain (493-602) Academic Article
- NMR solution structure of Cu(I) rusticyanin from Thiobacillus ferrooxidans: structural basis for the extreme acid stability and redox potential Academic Article
- NMR solution structure of the inserted domain of human leukocyte function associated antigen-1 Academic Article
- NMR structure of a cyclic polyamide-DNA complex Academic Article
- NMR structures of α-proteobacterial ATPase-regulating ζ-subunits Academic Article
- NMR studies of the conformations of leghemoglobins from soybean and lupin Academic Article
- NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41 Academic Article
- Na-23 NMR as a probe of ion binding to chromatin Academic Article
- Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: A focus on the transthyretin amyloidoses Academic Article
- Natural resistance of human immunodeficiency virus type 1 to the cd4bs antibody b12 conferred by a glycan and an arginine residue close to the cd4 binding loop Academic Article
- Natural supramolecular building blocks: Cysteine-added mutants of cowpea mosaic virus Academic Article
- Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells Academic Article
- Nature's inventory of halogenation catalysts: Oxidative strategies predominate Academic Article
- Negative regulation of human c-fos expression by the retinoblastoma gene-product Academic Article
- Negative regulation of the major histocompatibility complex class-I enhancer in adenovirus type 12-transformed cell via a retinoic acid response element Academic Article
- Negative stain single-particle EM of the maltose transporter in nanodiscs reveals asymmetric closure of MalK2 and catalytic roles of ATP, MalE, and maltose Academic Article
- Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle Academic Article
- Networks link antigenic and receptor-binding sites of influenza hemagglutinin: Mechanistic insight into fitter strain propagation Academic Article
- Neurite fasciculation mediated by complexes of axonin-1 and Ng cell adhesion molecule Academic Article
- Neuronal expression of a functional receptor for the C5a complement activation fragment Academic Article
- Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity Academic Article
- Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago Academic Article
- Neutralizing mutations of carboxylates that bind metal 2 in t5 flap endonuclease result in an enzyme that still requires two metal ions Academic Article
- New chemistry for the study of multiprotein complexes: The six-histidine tag as a receptor for a protein crosslinking reagent Academic Article
- New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix Academic Article
- New evidence on location of saccharide-binding site of concanavalin-a Academic Article
- New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: analysis of the epidermal growth factor-like repeat A docking site using WaterMap Academic Article
- Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1 Academic Article
- Nickel superoxide dismutase structure and mechanism Academic Article
- Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells Academic Article
- Nitric oxide binding to prokaryotic homologs of the soluble guanylate cyclase beta 1 h-nox domain Academic Article
- Nitric oxide synthase stabilizes the tetrahydrobiopterin cofactor radical by controlling its protonation state Academic Article
- Nitrosyl-heme structures of Bacillus subtilis nitric oxide synthase have implications for understanding substrate oxidation Academic Article
- Nmr and kinetic characterization of the interaction between french bean plastocyanin and horse cytochrome-c Academic Article
- Nmr spectroscopic studies of the DNA-binding domain of the monomer-binding nuclear orphan receptor, human estrogen related receptor-2 - the carboxyl-terminal extension to the zinc-finger region is unstructured in the free form of the protein Academic Article
- Nmr structure and metal interactions of the copz copper chaperone Academic Article
- Nmr structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the drosophila antennapedia protein Academic Article
- Nmr structure of the conserved hypothetical protein tm0487 from thermotoga maritima: Implications for 216 homologous duf59 proteins Academic Article
- Nmr structure of the human oncofoetal fibronectin ed-b domain, a specific marker for angiogenesis Academic Article
- Nmr structure reveals intramolecular regulation mechanism for pheromone binding and release Academic Article
- Nmr structures of salt-refolded forms of the 434-repressor DNA-binding domain in 6 m urea Academic Article
- Nmr studies of subunit c of the atp synthase from propionigenium modestum in dodecylsulphate micelles Academic Article
- Nmr-derived dynamic aspects of n-type inactivation of a kv channel suggest a transient interaction with the t1 domain Academic Article
- Nmr-studies of molecular-conformations in linear oligopeptides h-(l-ala)n-l-pro-oh Academic Article
- No formation by a catalytically self-sufficient bacterial nitric oxide synthase from sorangium cellulosum Academic Article
- Nob1 binds the single-stranded cleavage site d at the 3 '-end of 18s rRNA with its pin domain Academic Article
- Non-degradative ubiquitination of protein kinases Academic Article
- Nonessential active-site residues modulate selenosubtilisins kinetic mechanism Academic Article
- Nonneutralizing antibodies to the cd4-binding site on the gp120 subunit of human immunodeficiency virus type 1 do not interfere with the activity of a neutralizing antibody against the same site Academic Article
- Normal hydrocarbons tumble rapidly in a deep, water-soluble cavitand Academic Article
- Novel DNA binding specificities of a putative herpesvirus bzip oncoprotein Academic Article
- Novel DNA-binding motifs in the DNA-repair enzyme endonuclease-iii crystal-structure Academic Article
- Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold Academic Article
- Novel analogues of (R)-5-(methylamino)-5,6-dihydro-4H-imidazo 4,5,1-ij quinolin-2(1H)-one (sumanirole) provide clues to dopamine D-2/D-3 receptor agonist selectivity Academic Article
- Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase Academic Article
- Novel isoform of insulin receptor substrate p53/p58 is generated by alternative splicing in the crib/sh3-binding region Academic Article
- Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity Academic Article
- Novel sequence determinants in peroxisome proliferator signaling Academic Article
- Novel vinculin binding site of the IpaA invasin of Shigella Academic Article
- Novel-approach to water proton relaxation in paramagnetic ion macromolecule complexes Academic Article
- Nuclear magnetic resonance (15)N and (1)H resonance assignments and global fold of rusticyanin. Insights into the ligation and acid stability of the blue copper site Academic Article
- Nuclear magnetic resonance structure of a novel globular domain in RBM10 containing OCRE, the octamer repeat sequence motif Academic Article
- Nuclear magnetic resonance structure of the nucleic acid-binding domain of severe acute respiratory syndrome coronavirus nonstructural protein 3 Academic Article
- Nuclear magnetic resonance studies of a ribonuclease-dinucleoside phosphonate complex and their implications for the mechanism of the enzyme Academic Article
- Nuclear magnetic resonance titration curves of histidine ring protons. IV. The effects of phosphate and sulfate on ribonuclease Academic Article
- Nuclear receptor ligands and cofactor recruitment: is there a coactivator "on deck"? Academic Article
- Nuclear receptors and their selective pharmacologic modulators Academic Article
- Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer Academic Article
- Nuclear relaxation studies of the role of the essential metal in glyoxalase I Academic Article
- Nucleic acid encoding to program self-assembly in chemical biology Academic Article
- Nucleosome interaction surface of linker histone H1c is distinct from that of H1(0) Academic Article
- Nucleotide binding by the histidine kinase CheA Academic Article
- Nucleotide determinants for tRNA-dependent amino acid discrimination by a class I tRNA synthetase Academic Article
- Observation of an arsenic adduct in an acetyl esterase crystal structure Academic Article
- Observation of covalent intermediates in an enzyme mechanism at atomic resolution Academic Article
- Octahedral metal coordination in the active site of glyoxalase I as evidenced by the properties of Co(II)-glyoxalase I Academic Article
- On the relationship between GC content and the number of predicted microRNA binding sites by MicroInspector Academic Article
- On the role of electrostatic interactions in the design of protein-protein interfaces Academic Article
- On the use of DXMS to produce more crystallizable proteins: Structures of the T. Maritima proteins TM0160 and TM1171 Academic Article
- On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7 Academic Article
- Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene Academic Article
- Oncogenic transformation by the fox protein qin requires DNA binding Academic Article
- Opposing activities of c-fos and fra-2 on ap-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters Academic Article
- Optimization of adenosine 5 '-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening Academic Article
- Optimization of alpha-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site Academic Article
- Orchestration of coagulation protease signaling by tissue factor Academic Article
- Organ polarity in arabidopsis. Nozzle physically interacts with members of the yabby family Academic Article
- Origin of selectivity in the antibody 20f10-catalyzed yang cyclization Academic Article
- Origins of enhanced proton transport in the Y7F mutant of human carbonic anhydrase II Academic Article
- Orphanin FQ/nociceptin and naloxone benzoylhydrazone activate distinct receptors in BE(2)-C human neuroblastoma cells Academic Article
- Oxazolomycin biosynthesis in streptomyces albus ja3453 featuring an "acyltransferase-less" type i polyketide synthase that incorporates two distinct extender units Academic Article
- P21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized RHO exchange factor Academic Article
- P45(skp2) promotes p27(kip1) degradation and induces s phase in quiescent cells Academic Article
- P53 latency - c-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences Academic Article
- P53 latency - out of the blind alley Academic Article
- PDZ domains: More than just a glue Academic Article
- PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45 Academic Article
- Packing, specificity, and mutability at the binding interface between the p160 coactivator and creb-binding protein Academic Article
- Pan-ebolavirus protective therapy by two multifunctional human antibodies Academic Article
- Panning for snurms: Using cofactor profiling for the rational discovery of selective nuclear receptor modulators Academic Article
- Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain Academic Article
- Partial 1H NMR assignments of the Escherichia coli dihydrofolate reductase complex with folate: evidence for a unique conformation of bound folate Academic Article
- Partial agonists activate PPAR gamma using a helix 12 independent mechanism Academic Article
- Partial purification and characterization of a muscarinic acetylcholine receptor from rat cerebral cortex Academic Article
- Pax-3 contains domains for transcription activation and transcription inhibition Academic Article
- Pbx-hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner Academic Article
- Peptide ligands for a sugar-binding protein isolated from a random peptide library Academic Article
- Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides Academic Article
- Performance of a docking/molecular dynamics protocol for virtual screening of nutlin-class inhibitors of Mdmx Academic Article
- Perspective on computational and structural aspects of kinase discovery from IPK2014 Academic Article
- Pervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae Academic Article
- Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response Academic Article
- Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels Academic Article
- Phase diagrams map the properties of antiviral agents directed against hepatitis b virus core assembly Academic Article
- Phospho-regulation of kinetochore-microtubule attachments by the aurora kinase Ipl1p Academic Article
- Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases Academic Article
- Phosphorylation of RhoGDI by Pak1 mediates, dissociation of Rac GTPase Academic Article
- Phosphorylation of protein S by platelet kinases enhances its activated protein C cofactor activity Academic Article
- Phosphorylation of the Gal4 DNA-binding domain is essential for activator mono-ubiquitylation and efficient promoter occupancy Academic Article
- Phosphorylation of the ap2 mu subunit by aak1 mediates high affinity binding to membrane protein sorting signals Academic Article
- Photo-induced joining of a transfer RNA with its cognate aminoacyl-transfer RNA synthetase Academic Article
- Photoaffinity labelling of N-formyl peptide receptors Academic Article
- Photoaffinity labelling of the active site of the rat glutathione transferases 3-3 and 1-1 and human glutathione transferase A1-1 Academic Article
- Physical and chemical studies on bacterial superoxide dismutases - purification and some anion binding properties of iron-containing protein of escherichia-coli-b Academic Article
- Physical explanation of epr-spectrum observed during catalysis by enzymes utilizing coenzyme-b12 Academic Article
- Physical mapping of qbeta replicase binding-sites on qbeta rna Academic Article
- Picometer-scale conformational heterogeneity separates functional from nonfunctional states of a photoreceptor protein Academic Article
- Pilus chaperone fimc-adhesin fimh interactions mapped by trosy-NMR Academic Article
- Plasma protein S residues 37-50 mediate its binding to factor Va and inhibition of blood coagulation Academic Article
- Plasmalemmal insertion and modification of sodium channels at the nerve growth cone Academic Article
- Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin Academic Article
- Plasminogen receptors in the mediation of pericellular proteolysis Academic Article
- Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway Academic Article
- Platelets have more than one binding site for von Willebrand factor Academic Article
- Polo-like kinases inhibited by Wortmannin. Labeling site and downstream effects Academic Article
- Poly(Glu60Ala30Tyr10) (GAT)-induced IgG monoclonal-antibodies cross-react with various self and non-self antigens through the complementarity determining regions - comparison with igm monoclonal polyreactive natural antibodies Academic Article
- Polymorphisms a387p in thrombospondin-4 and n700s in thrombospondin-1 perturb calcium binding sites Academic Article
- Position and orientation independent transactivation by c-myc Academic Article
- Positional recognition of a tRNA determinant dependent on a peptide insertion Academic Article
- Positive effectors of the binding of an active site-directed amino steroid to rabbit cytochrome-P-450-3C Academic Article
- Predicting interactions of winged-helix transcription factors with DNA Academic Article
- Predicting the emergence of antibiotic resistance by directed evolution and structural analysis Academic Article
- Predicting transcription factor synergism Academic Article
- Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonist Academic Article
- Preferential recognition of avian-like receptors in human influenza A H7N9 viruses Academic Article
- Preparation and properties of a 3,4-dihydroxycinnamic acid chromophore variant of the photoactive yellow protein Academic Article
- Presynaptic modulation of spontaneous inhibitory postsynaptic currents by gamma-hydroxybutyrate in the substantia nigra pars compacta Academic Article
- Primary structure of bmk1 - a new mammalian map kinase Academic Article
- Primary structure of phage mu-transposase - homology to mu-repressor Academic Article
- Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate Academic Article
- Principles of quasi-equivalence and Euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes Academic Article
- Prion protein interaction with the c-terminal sh3 domain of grb2 studied using NMR and optical spectroscopy Academic Article
- Prion protein structural features indicate possible relations to signal peptidases Academic Article
- Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity Academic Article
- Probing a 2-aminobenzimidazole library for binding to RNA internal loops via two-dimensional combinatorial screening Academic Article
- Probing backbone hydrogen bonds in the hydrophobic core of GCN4 Academic Article
- Probing enzyme-substrate recognition and catalytic mechanism in Cu,Zn superoxide dismutase Academic Article
- Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter Academic Article
- Probing ligand recognition in the decarboxylase antibody 21d8: Implications for the catalytic mechanism Academic Article
- Probing soluble guanylate cyclase activation by co and yc-1 using resonance raman spectroscopy Academic Article
- Probing the Tetrahymena group I ribozyme reaction in both directions Academic Article
- Probing the active site of glyoxalase I from human erythrocytes by use of the strong reversible inhibitor S-p-bromobenzylglutathione and metal substitutions Academic Article
- Probing the active site of human manganese superoxide dismutase: The role of glutamine 143 Academic Article
- Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: Structures of the escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products Academic Article
- Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site Academic Article
- Probing the mechanism of Staphylococcal nuclease with unnatural amino-acids: kinetic and structural studies Academic Article
- Probing the open state of cytochrome P450cam with ruthenium-linker substrates Academic Article
- Probing the structural basis for enzyme-substrate recognition in Cu, Zn superoxide dismutase Academic Article
- Probing the substrate specificity and protein-protein interactions of the E. coli fatty acid dehydratase, FabA Academic Article
- Processing of integrin αv subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase Academic Article
- Processing of the psbA 5' untranslated region in Chlamydomonas reinhardtii depends upon factors mediating ribosome association Academic Article
- Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor alpha 1 Academic Article
- Production, characterization, and assessment of a stable analog of the response regulator CheY-phosphate from Thermotoga maritima Academic Article
- Prodynorphin gene-expression relates to nf-kappa-b factors Academic Article
- Profiling protein kinases and other ATP binding proteins in Arabidopsis using Acyl-ATP probes Academic Article
- Progesterone binding components of chick oviduct. X. Purification by affinity chromatography Academic Article
- Programmable base editing of A.T to G.C in genomic DNA without DNA cleavage Academic Article
- Progress in the design of DNA sequence-specific lexitropsins Academic Article
- Prolactin receptors in the ovary Academic Article
- Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV Academic Article
- Promoter scanning for transcription inhibition with DNA-binding polyamides Academic Article
- Promoter-targeted phage display selections with preassembled synthetic zinc finger libraries for endogenous gene regulation Academic Article
- Proofreading DNA - recognition of aberrant DNA termini by the klenow fragment of DNA-polymerase-i Academic Article
- Prostate-specific membrane antigen directed selective thrombotic infarction of tumors Academic Article
- Protein H: a bacterial surface protein with affinity for both immunoglobulin and fibronectin type III domains Academic Article
- Protein and Mg(2+)-induced conformational changes in the S15 binding site of 16 S ribosomal RNA Academic Article
- Protein arginine deiminase 4: Evidence for a reverse protonation mechanism Academic Article
- Protein arginine methyltransferase 1: Positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis Academic Article
- Protein cross-linking mediated by metal ion complexes Academic Article
- Protein flexibility in virtual screening: the BACE-1 case study Academic Article
- Protein metal-binding sites Academic Article
- Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with escherichia coli uracil-DNA glycosylase Academic Article
- Protein recognition by NMR Academic Article
- Protein structure and oligomerization are important for the formation of export-competent HIV-1 Rev-RRE complexes Academic Article
- Protein-ligand docking with multiple flexible side chains Academic Article
- Protein-peptide interactions Academic Article
- Protein-reactive natural products Academic Article
- Proteolytic processing of oligopeptides containing the target sequences by the recombinant tobacco vein mottling virus nia proteinase Academic Article
- Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype Academic Article
- Proteomic profiling of metalloprotease activities with cocktails of active-site probes Academic Article
- Proteomimetic libraries: Design, synthesis, and evaluation of p53-MDM2 interaction inhibitors Academic Article
- Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex Academic Article
- Proton magnetic resonance studies of human cyanomethemoglobin Academic Article
- Proton magnetic-resonance studies of peroxidases from turnip and horseradish Academic Article
- Proton nuclear magnetic resonance and electron paramagnetic resonance studies on skeletal muscle actin indicate that the metal and nucleotide binding sites are separate Academic Article
- Proton release due to manganese binding and oxidation in modified bacterial reaction centers Academic Article
- Proton-transfer effects in the active-site region of Escherichia coli thioredoxin using two-dimensional (1)H NMR Academic Article
- Protonation states and pH titration in the photocycle of photoactive yellow protein Academic Article
- Purification and immunological studies of glutathione reductase from rat liver. Evidence for an antigenic determinant at the nucleotide-binding domain of the enzyme Academic Article
- Purification and properties of progesterone receptors from chick oviduct Academic Article
- Purification of DT-diaphorase by affinity chromatography. Occurrence of two subunits and nonlinear Dixon and Scatchard plots of the inhibition by anticoagulants Academic Article
- Purification of cachectin, a lipoprotein-lipase suppressing hormone secreted by endotoxin-induced raw 264.7 cells Academic Article
- Purification of human uterine progesterone receptor Academic Article
- Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif Academic Article
- Qualitative and quantitative differences in t cell receptor binding of agonist and antagonist ligands Academic Article
- Quality control mechanisms during ribosome maturation Academic Article
- Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP Academic Article
- Quantitative fluorometric assay for detection and characterization of fc receptors Academic Article
- Quantum chemical studies of intermediates and reaction pathways in selected enzymes and catalytic synthetic systems Academic Article
- RNA recognition by designed peptide fusion creates "artificial" tRNA synthetase Academic Article
- RNA target specificity of the STAR/GSG domain post-transcriptional regulatory protein GLD-1 Academic Article
- RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint Academic Article
- Rabbit blood coagulation factor XI. Mechanism of activation of rabbit Hageman factor (factor XII) Academic Article
- Rad50/smc proteins and abc transporters: Unifying concepts from high-resolution structures Academic Article
- Radical-mediated enzymatic carbon chain fragmentation-recombination Academic Article
- Radioligand binding analysis of knockout mice reveals 5-hydroxytryptamine(7) receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with alpha(2) adrenergic receptors Academic Article
- Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening Academic Article
- Rapid identification of key amino-acid-DNA contacts through combinatorial peptide synthesis Academic Article
- Rapid identification of the pharmacophore in a peptoid inhibitor of the proteasome regulatory particle Academic Article
- Rapid, simple and sensitive method for demonstration of central catecholamine-containing neurons and axons by glyoxylic acid-induced fluorescence .2. Detailed description of methodology Academic Article
- Rate equations and simulation curves for enzymatic reactions which utilize lipids as substrates. II. Effect of adsorption of the substrate or enzyme on the steady-state kinetics Academic Article
- Rate of tritium labeling of specific purines in relation to nucleic acid and particularly transfer RNA conformation Academic Article
- Rational design and expression of a heparin-targeted human superoxide-dismutase Academic Article
- Rational design of a functional metalloenzyme: introduction of a site for manganese binding and oxidation into a heme peroxidase Academic Article
- Rational design of potent human transthyretin amyloid disease inhibitors Academic Article
- Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid Academic Article
- Rb interacts with TAF(II)250/TFIID through multiple domains Academic Article
- Reaction intermediates in the catalytic mechanism of escherichia coli muty DNA glycosylase Academic Article
- Reaction mechanism of single subunit nadh-ubiquinone oxidoreductase (ndi1) from saccharomyces cerevisiae evidence for a ternary complex mechanism Academic Article
- Reaction of cyanide with cytochrome-ba3 from thermus-thermophilus - spectroscopic characterization of the fe(ii)a3-cn-bullet-cu(ii)b-cn complex suggests 4 n-14 atoms are coordinated to cu(b) Academic Article
- Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide Academic Article
- Reactive immunization Academic Article
- Recent advances in developing small molecules targeting RNA Academic Article
- Recent developments and applications of clickable photoprobes in medicinal chemistry and chemical biology Academic Article
- Recent developments in the investigation of the paramagnetic centers in low-spin ferric hemoproteins: carbon-13 hyperfine shifts in iron porphyrin complexes Academic Article
- Recent results on how aminoacyl transfer RNA synthetases recognize specific transfer RNAs Academic Article
- Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 Academic Article
- Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses Academic Article
- Receptor for motilin identified in the human gastrointestinal system Academic Article
- Receptor for soluble c3 and c3b on human lymphoblastoid (raji) cells. Properties and biologocal significance Academic Article
- Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus Academic Article
- Recognition and sequestration of ω-fatty acids by a cavitand receptor Academic Article
- Recognition elements for 5 ' exon substrate binding to the Candida albicans group I intron Academic Article
- Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells Academic Article
- Recognition of sequence-directed DNA structure by the klenow fragment of DNA polymerase i Academic Article
- Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies Academic Article
- Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein Academic Article
- Recognition of the mrna au-rich element by the zinc finger domain of tis11d Academic Article
- Recognition properties of a panel of human recombinant fab fragments to the cd4 binding-site of gp120 that show differing abilities to neutralize human-immunodeficiency-virus type-1 Academic Article
- Recognition templates for predicting adenylate-binding sites in proteins Academic Article
- Recovery of soluble sheep erythrocyte receptor from the T lymphocyte surface by proteolytic cleavage Academic Article
- Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections Academic Article
- Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation Academic Article
- Redesigning enzyme topology by directed evolution Academic Article
- Rediocides A and G as potential antitoxins against cobra venom Academic Article
- Redox protein electron-transfer mechanisms - electrostatic interactions as a determinant of reaction site in c-type cytochromes Academic Article
- Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype a: Extending towards the beta-exosite Academic Article
- Refined crystallographic structure of pseudomonas aeruginosa exotoxin a and its implications for the molecular mechanism of toxicity Academic Article
- Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution Academic Article
- Regulated expression of alpha-2,6-sialyltransferase by the liver-enriched transcription factors hnf-1, dbp, and lap Academic Article
- Regulation in-vitro of an l-cam enhancer by homeobox genes hoxd9 and hnf-1 Academic Article
- Regulation of acetylcholine receptors on chick ciliary ganglion neurons by components from the synaptic target tissue Academic Article
- Regulation of adenovirus membrane penetration by the cytoplasmic tail of integrin beta 5 Academic Article
- Regulation of cell adhesion by PAI-1 Academic Article
- Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor alpha (ror alpha) Academic Article
- Regulation of gene expression by small molecules Academic Article
- Regulation of human lymphocyte function by a soluble extract from normal human liver Academic Article
- Regulation of the MEF2 family of transcription factors by p38 Academic Article
- Regulation of the catalytic function of coagulation factor viia by a conformational linkage of surface residue glu 154 to the active site Academic Article
- Regulation of the human bilirubin UDP-glucuronosyltransferase gene Academic Article
- Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation Academic Article
- Regulation of von Willebrand factor binding to the platelet glycoprotein Ib-IX by a membrane skeleton-dependent inside-out signal Academic Article
- Relationship between major histocompatibility antigens and disease - possible associations with human arenavirus diseases Academic Article
- Relationship of the human-immunodeficiency-virus type-1 gp120 3rd variable loop to a component of the cd4 binding-site in the 4th conserved region Academic Article
- Relationship of two human tRNA synthetases used in cell signaling Academic Article
- Relationships between structure and activities of concanavalin a Academic Article
- Relative contributions of the zinc fingers of transcription factor IIIA to the energetics of DNA-binding Academic Article
- Relative implication of peptide residues in binding to major histocompatibility complex class-i h-2d(b) - application to the design of high-affinity, allele-specific peptides Academic Article
- Relaxation dynamics of Pseudomonas aeruginosa Re(I)(CO)3(alpha-diimine)(HisX)(+) (X = 83, 107, 109, 124, 126)Cu(II) azurins Academic Article
- Relaxation spectra of the iron spin transition in methemoglobin Academic Article
- Repair complexes of fen1 endonuclease, DNA, and rad9-hus1-rad1 are distinguished from their pcna counterparts by functionally important stability Academic Article
- Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure Academic Article
- Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 2. Effects on heme coordination and function Academic Article
- Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast Academic Article
- Requirement of helix 1 and the af-2 domain of the thyroid hormone receptor for coactivation by pgc-1 Academic Article
- Residue met(156) contributes to the labile enzyme conformation of coagulation factor viia Academic Article
- Residues in a class I tRNA synthetase which determine selectivity of amino acid recognition in the context of tRNA Academic Article
- Resolution of site-specific conformational heterogeneity in proline-rich molecular recognition by Src homology 3 domains Academic Article
- Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin a Academic Article
- Resynchronization of rna synthesis by coliphage qbeta replicase at an internal site of the rna template Academic Article
- Reversal of ADP-mediated aggregation of adenosine kinase by cyclophilin leads to its reactivation Academic Article
- Reversible regulation of tissue factor-induced coagulation by glycosyl phosphatidylinositol-anchored tissue factor pathway inhibitor Academic Article
- Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains Academic Article
- Rhombohedral crystals of the human vinculin head domain in complex with a vinculin-binding site of talin Academic Article
- Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding Academic Article
- Ribosomal-RNA genes in nucleus and chloroplast of Euglena Academic Article
- Ribosome assembly factors prevent premature translation initiation by 40S assembly intermediates Academic Article
- Rigid body refinement of protein complexes with long-range distance restraints from pulsed dipolar ESR Academic Article
- Role of DNA sequence in the binding specificity of synthetic basic-helix-loop-helix domains Academic Article
- Role of RNA structure in arginine recognition of TAR RNA Academic Article
- Role of Rab9 GTPase in facilitating receptor recruitment by TIP47 Academic Article
- Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome Academic Article
- Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase Academic Article
- Role of an active site adenine in hairpin ribozyme catalysis Academic Article
- Role of an active site guanine in hairpin ribozyme catalysis probed by exogenous nucleobase rescue Academic Article
- Role of aspartate-37 in determining cofactor specificity and binding in rat-liver dihydropteridine reductase Academic Article
- Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization Academic Article
- Role of cyclic nucleotides in central synaptic function Academic Article
- Role of electrostatic interactions in PDZ domain ligand recognition Academic Article
- Role of gtp hydrolysis in microtubule dynamics - information from a slowly hydrolyzable analog, gmpcpp Academic Article
- Role of hydrogen bonding in the active site of human manganese superoxide dismutase Academic Article
- Role of the glutamyl alpha-carboxylate of the substrate glutathione in the catalytic mechanism of human glutathione transferase A1-1 Academic Article
- Role of third intracellular loop of galanin receptor type 1 in signal transduction Academic Article
- Role of tryptophan 161 in catalysis by human manganese superoxide dismutase Academic Article
- Role of zymogen and activated factor x as scaffolds for the inhibition of the blood coagulation factor viia-tissue factor complex by recombinant nematode anticoagulant protein c2 Academic Article
- Roles of Dim2 in ribosome assembly Academic Article
- Roles of IFN consensus sequence binding protein and PU.1 in regulating IL-18 gene expression Academic Article
- Roles of bound quinone in the single subunit nadh-quinone oxidoreductase (ndi1) from saccharomyces cerevisiae Academic Article
- Rotational correlation time of concanavalin-a after interaction with a fluorescent-probe Academic Article
- Routes to catalysis - structure of a catalytic antibody and comparison with its natural counterpart Academic Article
- Rrna-complementarity in the 5 ' untranslated region of mrna specifying the gtx homeodomain protein: Evidence that base-pairing to 18s rrna affects translational efficiency Academic Article
- S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration Academic Article
- S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death Academic Article
- S1p(1)-selective in vivo-active agonists from high-throughput screening: Off-the-shelf chemical probes of receptor interactions, signaling, and fate Academic Article
- SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 Academic Article
- SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling Academic Article
- SDOCKER: A method utilizing existing X-ray structures to improve docking accuracy Academic Article
- SIR1, an upstream component in auxin signaling identified by chemical genetics Academic Article
- SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine Academic Article
- SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation Academic Article
- SR2067 reveals a unique kinetic and structural signature for PPARγ partial agonism Academic Article
- SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent Academic Article
- STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells Academic Article
- SUMO-binding motifs mediate the Rad60-dependent response to replicative stress and self-association Academic Article
- SV40 T antigen interacts with Nbs1 to disrupt DNA replication control Academic Article
- Saccharomyces cerevisiae lme2 phosphorylates Sic1 at multiple PXS/T sites but is insufficient to trigger Sic1 degradation Academic Article
- Salicylates are interference compounds in TR-FRET assays Academic Article
- Screening a peptidyl database for potential ligands to proteins with side-chain flexibility Academic Article
- Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay Academic Article
- Screening transthyretin amyloid fibril inhibitors: Characterization of novel multiprotein, multiligand complexes by mass spectrometry Academic Article
- Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2 Academic Article
- Selecting against s1p(3) enhances the acute cardiovascular tolerability of 3-(n-benzyl)aminopropylphosphonic acid s1p receptor agonists Academic Article
- Selection and application of peptide-binding peptides Academic Article
- Selection by site-directed antibodies of small regions of peptides which are ordered in water Academic Article
- Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms Academic Article
- Selection of apoptotic cell specific human antibodies from adult bone marrow Academic Article
- Selection pressure on hiv-1 envelope by broadly neutralizing antibodies to the conserved cd4-binding site Academic Article
- Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites Academic Article
- Selective attenuation of the extrinsic limb of the tissue factor-driven coagulation protease cascade by occupancy of a novel peptidyl docking site on tissue factor Academic Article
- Selective binding-site for (prostacyclin-h-3 on platelets Academic Article
- Selective chemical catalysis by an antibody Academic Article
- Selective inhibition of ADAR2-catalyzed editing of the serotonin 2c receptor pre-mRNA by a helix-threading peptide Academic Article
- Selective interaction of heparin with the variable region 3 within surface glycoprotein of laboratory-adapted feline immunodeficiency virus Academic Article
- Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120 Academic Article
- Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets Academic Article
- Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for analysis of peptide hormone interactions with bovine neurophysin i using 13C nuclear magnetic-resonance spectroscopy Academic Article
- Selectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuations Academic Article
- Self-association of the histidine kinase CheA as studied by pulsed dipolar ESR spectroscopy Academic Article
- Sendai virus utilizes specific sialyloligosaccharides as host-cell receptor determinants Academic Article
- Sensitizer-linked substrates and ligands: Ruthenium probes of cytochrome P450 structure and mechanism Academic Article
- Separate cell-binding sites within cytotactin tenascin differentially promote neurite outgrowth Academic Article
- Sequence and structural convergence of broad and potent hiv antibodies that mimic cd4 binding Academic Article
- Sequence homology and structural analysis of the clostridial neurotoxins Academic Article
- Sequence, structure and energetic determinants of phosphopeptide selectivity of SH2 domains Academic Article
- Sequence-specific NMR assignment of proteins by global fragment mapping with the program mapper Academic Article
- Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides Academic Article
- Sequence-specific resonance assignments in the h-1-NMR spectrum of the lac repressor DNA-binding domain 1-51 from escherichia-coli by two-dimensional spectroscopy Academic Article
- Sequential action of MalE and maltose allows coupling ATP hydrolysis to translocation in the MalFGK(2) transporter Academic Article
- Ser-884 adjacent to the lxxll motif of coactivator trbp defines selectivity for ers and trs Academic Article
- Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations Academic Article
- Serine hydrolase KIAA1363: Toxicological and structural features with emphasis on organophosphate interactions Academic Article
- Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport Academic Article
- Seven clues to the origin and structure of class-I ribonucleotide reductase intermediate X Academic Article
- Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme Academic Article
- Shape complementarity of protein-protein complexes at multiple resolutions Academic Article
- Shape-specific nucleotide binding of single-stranded RNA by the GLD-1 STAR domain Academic Article
- Shigella applies molecular mimicry to subvert vinculin and invade host cells Academic Article
- Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines Academic Article
- Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells Academic Article
- Side-chain conformational heterogeneity of intermediates in the Escherichia coli dihydrofolate reductase catalytic cycle Academic Article
- Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells Academic Article
- Significant structural and functional change of an antigen-binding site by a distant amino-acid substitution - proposal of a structural mechanism Academic Article
- Simple method for production of specific xenoantisera to human histocompatibility (hla-a, hla-b, hla-c) antigens Academic Article
- Simple reporter gene-based assays for hairpin poly(amide) conjugate permeability and DNA-binding activity in living cells Academic Article
- Simultaneous binding of two proteins to opposite sides of a single transfer RNA Academic Article
- Single sequence of a helix-loop peptide confers functional anticodon recognition on two tRNA synthetases Academic Article
- Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR Academic Article
- Single-step inline hydroxyapatite enrichment facilitates identification and quantitation of phosphopeptides from mass-limited proteomes with MudPIT Academic Article
- Site-Specific Bioorthogonal Labeling for Fluorescence Imaging of Intracellular Proteins in Living Cells Academic Article
- Site-Specific Lipidation Enhances IFITM3 Membrane Interactions and Antiviral Activity Academic Article
- Site-directed mutagenesis of the complement c5a receptor - examination of a model for its interaction with the ligand c5a Academic Article
- Site-directed mutagenesis of the human beta(3)-adrenoceptor - transmembrane residues involved in ligand binding and signal transduction Academic Article
- Site-selective cleavage of structured RNA by a Staphylococcal nuclease DNA hybrid Academic Article
- Site-specific acylation of a bacterial virulence regulator attenuates infection Academic Article
- Site-specific glycoconjugation of protein via bioorthogonal tetrazine cycloaddition with a genetically encoded trans-cyclooctene or bicyclononyne Academic Article
- Site-specific immobilization of enzymes on magnetic nanoparticles and their use in organic synthesis Academic Article
- Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept Academic Article
- Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intron Academic Article
- Small molecule modulation of nuclear receptor conformational dynamics: implications for function and drug discovery Academic Article
- Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport Academic Article
- Small terminase couples viral DNA binding to genome-packaging ATPase activity Academic Article
- Small-molecule binding to an artificially created cavity at the active-site of cytochrome-c peroxidase Academic Article
- Small-molecule effectors of hepatitis b virus capsid assembly give insight into virus life cycle Academic Article
- Small-molecule inhibitors of the c-Fes protein-tyrosine kinase Academic Article
- Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity Academic Article
- Sodium ion binding pocket mutations and adenosine A2A receptor function Academic Article
- Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain Academic Article
- Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing Academic Article
- Solution structure of Escherichia coli glutaredoxin-2 shows similarity to mammalian glutathione-S-transferases Academic Article
- Solution structure of rnase p rna Academic Article
- Solution structure of sperm lysin yields novel insights into molecular dynamics of rapid protein evolution Academic Article
- Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions Academic Article
- Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP Academic Article
- Solution structure of the cysteine-rich domain of the Escherichia coli chaperone protein DnaJ Academic Article
- Solution structure of the kix domain of cbp bound to the transactivation domain of c-myb Academic Article
- Solution structure of the third immunoglobulin domain of the neural cell adhesion molecule N-CAM: can solution studies define the mechanism of homophilic binding? Academic Article
- Some new views of the cell surface Academic Article
- Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization Academic Article
- Spatially directed assembly of a heterotetrameric Cre-Lox synapse restricts recombination specificity Academic Article
- Species barrier to RNA recognition overcome with nonspecific RNA binding domains Academic Article
- Species-specific tRNA recognition in relation to tRNA synthetase contact residues Academic Article
- Specific binding of RGS9-G beta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity Academic Article
- Specific fractionation of immune cell populations Academic Article
- Specific killing of hiv-infected lymphocytes by a recombinant immunotoxin directed against the hiv-1 envelope glycoprotein Academic Article
- Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide Academic Article
- Spectroscopic characterization of the heme-binding sites in plasmodium falciparum histidine-rich protein 2 Academic Article
- Spectroscopic studies of the DNA-binding site of the gal4 zinc finger protein Academic Article
- Sphingolipids as bioactive regulators of thrombin generation Academic Article
- Spontaneous platelet aggregation in type IIB Tampa von Willebrand disease is inhibited by the 52/48-kDa fragment of normal von Willebrand factor, which contains the GPIb binding domain Academic Article
- Stability of hairpin ribozyme tertiary structure is governed by the interdomain junction Academic Article
- Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function Academic Article
- Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3cl protease Academic Article
- Starving the malaria parasite: Inhibitors active against the aspartic proteases plasmepsins I, II, and IV Academic Article
- Statistical positioning of nucleosomes by specific protein-binding to an upstream activating sequence in yeast Academic Article
- Status of gpcr modeling and docking as reflected by community-wide gpcr dock 2010 assessment Academic Article
- Stimulation of lymphocyte transformation by streptococcal type m1 protein: Relationship to hl-a antigens Academic Article
- Stimulation of nuclear export and inhibition of nuclear import by a ran mutant deficient in binding to ran-binding protein 1 Academic Article
- Strained cyclic disulfides enable cellular uptake by reacting with the transferrin receptor Academic Article
- Streptococcal m1 protein constructs a pathological host fibrinogen network Academic Article
- Striated muscle activator of Rho signalling (STARS) is a PGC-1 alpha/oestrogen-related receptor-alpha target gene and is upregulated in human skeletal muscle after endurance exercise Academic Article
- Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling Academic Article
- Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains Academic Article
- Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1 Academic Article
- Structural analysis of caspase-1 inhibitors derived from Tethering Academic Article
- Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate Academic Article
- Structural analysis of inhibitor binding to human carbonic anhydrase II Academic Article
- Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity Academic Article
- Structural analysis of papain-like NlpC/p60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites Academic Article
- Structural and biochemical characterization of the therapeutic anabaena variabilis phenylalanine ammonia lyase Academic Article
- Structural and biophysical characterization of the EphB4.ephrinB2 protein-protein interaction and receptor specificity Academic Article
- Structural and functional analysis of the plasminogen activator inhibitor-1 binding motif in the somatomedin B domain of vitronectin Academic Article
- Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes Academic Article
- Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants Academic Article
- Structural and functional studies of the measles virus hemagglutinin: Identification of a novel site required for cd46 interaction Academic Article
- Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II Academic Article
- Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6 Academic Article
- Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome p4502b4 Academic Article
- Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles Academic Article
- Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair Academic Article
- Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors Academic Article
- Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor Academic Article
- Structural basis for amplifying vinculin activation by talin Academic Article
- Structural basis for bifunctional peptide recognition at human delta-opioid receptor Academic Article
- Structural basis for chloramphenicol tolerance in Streptomyces venezuelae by chloramphenicol phosphotransferase activity Academic Article
- Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases Academic Article
- Structural basis for endothelial nitric oxide synthase binding to calmodulin Academic Article
- Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase Academic Article
- Structural basis for hif-1 alpha/cbp recognition in the cellular hypoxic response Academic Article
- Structural basis for high-affinity peptide inhibition of human Pin1 Academic Article
- Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics Academic Article
- Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase Academic Article
- Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway Academic Article
- Structural basis for molecular recognition at serotonin receptors Academic Article
- Structural basis for recognition and catalysis by the bifunctional dctp deaminase and dutpase from methanococcus jannaschii Academic Article
- Structural basis for recruitment of cbp/p300 coactivators by stat1 and stat2 transactivation domains Academic Article
- Structural basis for specific inhibition of tRNA synthetase by an ATP competitive inhibitor Academic Article
- Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase Academic Article
- Structural basis for the coevolution of a viral RNA-protein complex Academic Article
- Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases Academic Article
- Structural basis for type-I and type-II deficiencies of antithrombotic plasma protein-C - patterns revealed by 3-dimensional molecular modeling of mutations of the protease domain Academic Article
- Structural basis of IMP3 RRM12 recognition of RNA Academic Article
- Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2 Academic Article
- Structural basis of Rho GTPase-mediated activation of the formin rndia1 Academic Article
- Structural basis of a shared antibody response to SARS-CoV-2 Academic Article
- Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain Academic Article
- Structural basis of alpha-fucosidase inhibition by iminocyclitols with K(i) values in the micro- to picomolar range Academic Article
- Structural basis of autoregulation of phenylalanine hydroxylase Academic Article
- Structural basis of cell surface receptor recognition by botulinum neurotoxin B Academic Article
- Structural basis of immune evasion at the site of cd4 attachment on hiv-1 gp120 Academic Article
- Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion Academic Article
- Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R Academic Article
- Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters Academic Article
- Structural basis of single-nucleotide polymorphisms in cytochrome P450 2C9 Academic Article
- Structural basis of steroid hormone perception by the receptor kinase bri1 Academic Article
- Structural basis of substrate methylation and inhibition of SMYD2 Academic Article
- Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant Academic Article
- Structural biochemistry and interaction architecture of the DNA double-strand break repair mre11 nuclease and rad50-atpase Academic Article
- Structural biology of the S1P1 receptor Academic Article
- Structural changes in the heme proximal pocket induced by nitric oxide binding to soluble guanylate cyclase Academic Article
- Structural changes that occur upon photolysis of the fe(ii)(a3)-co complex in the cytochrome ba(3)-oxidase of thermus thermophilus: A combined x-ray crystallographic and infrared spectral study demonstrates co binding to cu-b Academic Article
- Structural characterization of S100A15 reveals a novel zinc coordination site among S100 proteins and altered surface chemistry with functional implications for receptor binding Academic Article
- Structural characterization of a p-acetylphenylalanyl aminoacyl-tRNA synthetase Academic Article
- Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism Academic Article
- Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica Academic Article
- Structural characterization of enterobactin hydrolase IroE Academic Article
- Structural characterization of the 1918 influenza virus h1n1 neuraminidase Academic Article
- Structural characterization of the Z ring-eIF4E complex reveals a distinct mode of control for eIF4E Academic Article
- Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the clostridium botulinum serotype a neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility Academic Article
- Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS Academic Article
- Structural definition of a conserved neutralization epitope on HIV-1 gp120 Academic Article
- Structural determinants in domain II of human glutathione transferase M2-2 govern the characteristic activities with aminochrome, 2-cyano-1,3-dimethyl-1-nitrosoguanidine, and 1,2-dichloro-4-nitrobenzene Academic Article
- Structural determinants of binding the seven-transmembrane domain of the glucagon-like peptide-1 receptor (GLP-1R) Academic Article
- Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members Academic Article
- Structural determinants of rotavirus subgroup specificity mapped by cryo-electron microscopy Academic Article
- Structural dynamics of hiv-1 rev and its complexes with rre and 5s rna Academic Article
- Structural evidence for substrate strain in antibody catalysis Academic Article
- Structural features for functional selectivity at serotonin receptors Academic Article
- Structural identification of the antibody-binding sites of hong-kong influenza hemagglutinin and their involvement in antigenic variation Academic Article
- Structural insight into pH-induced conformational changes within the native human transthyretin tetramer Academic Article
- Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants Academic Article
- Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor Academic Article
- Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein Academic Article
- Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B Academic Article
- Structural insights into protein-metal ion partnerships Academic Article
- Structural insights into the avian aicar transformylase mechanism Academic Article
- Structural insights into the evolution of an antibody combining site Academic Article
- Structural insights into the function of the rab gdi superfamily Academic Article
- Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor Academic Article
- Structural insights into the mechanisms of mg2+ uptake, transport, and gating by cora Academic Article
- Structural insights into the molecular mechanism of h-nox activation Academic Article
- Structural insights into the recognition of phosphopeptide by the FHA domain of kanadaptin Academic Article
- Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins Academic Article
- Structural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103 Academic Article
- Structural invariance of constitutively active and inactive mutants of acanthamoeba myosin ic bound to f-actin in the rigor and adp-bound states Academic Article
- Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus Academic Article
- Structural mechanism of abscisic acid binding and signaling by dimeric PYR1 Academic Article
- Structural mimicry in the phage phi 21 N peptide-boxB RNA complex Academic Article
- Structural model studies for the peroxo intermediate P and the reaction pathway from P -> Q of methane monooxygenase using broken-symmetry density functional calculations Academic Article
- Structural organization of complexes of transfer RNAs with aminoacyl transfer RNA synthetases Academic Article
- Structural plasticity and the evolution of antibody affinity and specificity Academic Article
- Structural properties of non-traditional drug targets present new challenges for virtual screening Academic Article
- Structural representative of the protein family PF14466 has a new fold and establishes links with the C2 and PLAT domains from the widely distant Pfams PF00168 and PF01477 Academic Article
- Structural role of a buried salt bridge in the 434 repressor DNA-binding domain Academic Article
- Structural studies of FIV and HIV-1 proteases complexed with all efficient inhibitor of FIV protease Academic Article
- Structural studies of atom-specific anticancer drugs acting on DNA Academic Article
- Structural studies of cytochrome c-551 by h-1 NMR-spectroscopy at 360 mhz Academic Article
- Structural studies of p21(waf1/cip1/sdi1) in the free and cdk2-bound state: Conformational disorder mediates binding diversity Academic Article
- Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors Academic Article
- Structural variations in species B adenovirus fibers impact CD46 association Academic Article
- Structural-analysis of rauscher virus gp70 using monoclonal-antibodies - sites of antigenicity and p15(e) linkage Academic Article
- Structural-based analysis of dihydrofolate reductase evolution Academic Article
- Structure analysis of peptide deformylases from Streptococcus pneumoniae, Staphylococcus aureus, Thermotoga maritima and Pseudomonas aeruginosa: Snapshots of the oxygen sensitivity of peptide deformylase Academic Article
- Structure and activity of a thermostable thymine-DNA glycosylase: Evidence for base twisting to remove mismatched normal DNA bases Academic Article
- Structure and dynamics of the liver receptor homolog 1-PGC1α complex Academic Article
- Structure and function of a genetically engineered mimic of a nonenveloped virus entry intermediate Academic Article
- Structure and function of a novel LD-carboxypeptidase A involved in peptidoglycan recycling Academic Article
- Structure and function of an unusual family of protein phosphatases: the bacterial chemotaxis proteins CheC and CheX Academic Article
- Structure and function of helix-loop-helix proteins Academic Article
- Structure and function of phage rna Academic Article
- Structure and function of the von Willebrand factor A1 domain Academic Article
- Structure and function of von Willebrand factor: relationship to von Willebrand's disease Academic Article
- Structure and functional characterization of the rna-binding element of the nlrx1 innate immune modulator Academic Article
- Structure and functional role of dynein's microtubule-binding domain Academic Article
- Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634 Academic Article
- Structure and lytic activity of a bacillus anthracis prophage endolysin Academic Article
- Structure and mechanism of copper, zinc superoxide-dismutase Academic Article
- Structure and mechanism of the ruvb holliday junction branch migration motor Academic Article
- Structure and mutational analysis of Rab GDP-dissociation inhibitor Academic Article
- Structure and receptor specificity of the hemagglutinin from an h5n1 influenza virus Academic Article
- Structure and thermodynamic characterization of the ephb4/ephrin-b2 antagonist peptide complex reveals the determinants for receptor specificity Academic Article
- Structure at 0.85 Å resolution of an early protein photocycle intermediate Academic Article
- Structure based prediction of subtype-selectivity for adenosine receptor antagonists Academic Article
- Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes Academic Article
- Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 A resolution: The first structural representative of a new protein family that may play a role in carbohydrate metabolism Academic Article
- Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding Academic Article
- Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Academic Article
- Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase Academic Article
- Structure of Thermotoga maritima TM0439: Implications for the mechanism of bacterial GntR transcription regulators with Zn(2+)-binding FCD domains Academic Article
- Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion Academic Article
- Structure of a cation-bound multidrug and toxic compound extrusion transporter Academic Article
- Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator Academic Article
- Structure of a dicationic monoimidazole lexitropsin bound to DNA Academic Article
- Structure of a kinesin microtubule depolymerization machine Academic Article
- Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site Academic Article
- Structure of a nitric oxide synthase heme protein from Bacillus subtilis Academic Article
- Structure of a protein photocycle intermediate by millisecond time-resolved crystallography Academic Article
- Structure of a thioredoxin-like 2fe-2s ferredoxin from aquifex aeolicus Academic Article
- Structure of a trimeric nucleoporin complex reveals alternate oligomerization states Academic Article
- Structure of a v3-containing hiv-1 gp120 core Academic Article
- Structure of activated aconitase - formation of the 4fe-4s cluster in the crystal Academic Article
- Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation Academic Article
- Structure of an agonist-bound human A₂A adenosine receptor Academic Article
- Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases Academic Article
- Structure of avian aicar transformylase with a multisubstrate adduct inhibitor β-DADF identifies the folate binding site Academic Article
- Structure of azotobacter vinelandii 7fe ferredoxin at 1.35 Å resolution and determination of the fe-s bonds with 0.01 Å accuracy Academic Article
- Structure of botulinurn neurotoxin type d light chain at 1.65 Å resolution: Repercussions for vamp-2 substrate specificity Academic Article
- Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5a resolution using amino-acid sequence data Academic Article
- Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway Academic Article
- Structure of hiv-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility Academic Article
- Structure of human cyclophilin and its binding-site for cyclosporine-a determined by x-ray crystallography and NMR-spectroscopy Academic Article
- Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site Academic Article
- Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding Academic Article
- Structure of mammalian poly(adp- ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element Academic Article
- Structure of microsomal cytochrome p4502b4 complexed with the antifungal drug bifonazole - insight into p450 conformational plasticity and membrane interaction Academic Article
- Structure of nitric oxide synthase oxygenase dimer with pterin and substrate Academic Article
- Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab Academic Article
- Structure of the CAD domain of caspase-activated DNase and interaction with the CAD domain of its inhibitor Academic Article
- Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex Academic Article
- Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone Academic Article
- Structure of the DNA repair and replication endonuclease and exonuclease fen-1: Coupling DNA and pcna binding to fen-1 activity Academic Article
- Structure of the DNA repair enzyme endonuclease iv and its DNA complex: Double-nucleotide flipping at abasic sites and three-metal-ion catalysis Academic Article
- Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation Academic Article
- Structure of the I-1 early intermediate of photoactive yellow protein by FTIR spectroscopy Academic Article
- Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding Academic Article
- Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain Academic Article
- Structure of the actin-myosin complex and its implications for muscle-contraction Academic Article
- Structure of the hemagglutinin membrane glycoprotein of influenza-virus at 3-a resolution Academic Article
- Structure of the heterodimeric complex between CAD domains of CAD and ICAD Academic Article
- Structure of the human ATG12 similar to ATG5 conjugate required for LC3 lipidation in autophagy Academic Article
- Structure of the human Dicer-TRBP complex by electron microscopy Academic Article
- Structure of the human P2Y(12) receptor in complex with an antithrombotic drug Academic Article
- Structure of the human TRPM4 ion channel in a lipid nanodisc Academic Article
- Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist Academic Article
- Structure of the human epithelial sodium channel by cryo-electron microscopy Academic Article
- Structure of the human glucagon class B G-protein-coupled receptor Academic Article
- Structure of the human histamine h(1) receptor complex with doxepin Academic Article
- Structure of the human smoothened receptor bound to an antitumour agent Academic Article
- Structure of the human κ-opioid receptor in complex with JDTic Academic Article
- Structure of the influenza-virus hemagglutinin complexed with its receptor, sialic-acid Academic Article
- Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity Academic Article
- Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic Academic Article
- Structure of the nuclear factor aly: Insights into post-transcriptional regulatory and mrna nuclear export processes Academic Article
- Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of creb binding protein Academic Article
- Structure of the uncleaved human h1 hemagglutinin from the extinct 1918 influenza virus Academic Article
- Structure of the von Willebrand factor domain interacting with glycoprotein Ib Academic Article
- Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction Academic Article
- Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase Academic Article
- Structure of transfer RNA-aminoacyl transfer RNA synthetase complexes investigated by nuclease digestion Academic Article
- Structure of yeast RNA polymerase II in solution: Implications for enzyme regulation and interaction with promoter DNA Academic Article
- Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D28K Academic Article
- Structure, lipid scrambling activity and role in autophagosome formation of ATG9A Academic Article
- Structure, redox, pKa, spin. A golden tetrad for understanding metalloenzyme energetics and reaction pathways Academic Article
- Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105 Academic Article
- Structure-activity relationships in a peptidic alpha 7 nicotinic acetylcholine receptor antagonist Academic Article
- Structure-activity relationships in flexible protein domains: Regulation of Rho GTPases by RhoGDI and D4 GDI Academic Article
- Structure-activity relationships in the binding of chemically derivatized cd4 to gp120 from human immunodeficiency virus Academic Article
- Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases Academic Article
- Structure-based active site profiles for genome analysis and functional family subclassification Academic Article
- Structure-based analysis of Bacilli and plasmid dihydrofolate reductase evolution Academic Article
- Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids Academic Article
- Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase Academic Article
- Structure-based discovery of cellular-active allosteric inhibitors of FAK Academic Article
- Structure-based engineering of internal cavities in coiled-coil peptides Academic Article
- Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors Academic Article
- Structure-based mutagenesis approaches toward expanding the substrate specificity of d-2-deoxyribose-5-phosphate aldolase Academic Article
- Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine Academic Article
- Structure-based stabilization of hiv-1 gp120 enhances humoral immune responses to the induced co-receptor binding site Academic Article
- Structure-based, targeted deglycosylation of hiv-1 gp120 and effects on neutralization sensitivity and antibody recognition Academic Article
- Structure-function relationship of proteins belonging to the family of receptors coupled to gtp-binding proteins Academic Article
- Structure-function relationships of platelet glycoprotein Ib as a receptor for von Willebrand factor Academic Article
- Structure-guided inhibitor design for human FAAH by interspecies active site conversion Academic Article
- Structure/function studies on a S-adenosyl-(L)-methionine-dependent uroporphyrinogen III C methyltransferase (SUMT), a key regulatory enzyme of tetrapyrrole biosynthesis Academic Article
- Structures of EF-hand Ca2+-binding proteins: diversity in the organization, packing and response to Ca2+ binding Academic Article
- Structures of clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility Academic Article
- Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition Academic Article
- Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457 Academic Article
- Structures of the N-omega-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins Academic Article
- Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: Heme activation via reduction-gated exogenous ligand exchange Academic Article
- Studies of bovine neurophysin-neurohypophyseal hormone interactions Academic Article
- Studies of histidine residues of triose phosphate isomerase by proton magnetic-resonance and x-ray crystallography Academic Article
- Studies of reactions of substituted d,l-erythro-beta-phenylserines with lamb liver serine hydroxymethylase - effects of substituents upon de-aldolization step Academic Article
- Studies on reconstitution of bovine erythrocyte superoxide dismutase .1. Presence of four divalent metal-binding sites on apo protein which are different from native sites Academic Article
- Studies on reconstitution of bovine erythrocyte superoxide dismutase .3. Evidence for a strong interdependence between cu2+ and zn2+ binding in expression of spectroscopic properties of native protein and for a close proximity of zn2+ and cu2+ sites Academic Article
- Studies on reconstitution of bovine erythrocyte superoxide dismutase .4. Preparation and some properties of enzyme in which co(ii) is substituted for zn(ii) Academic Article
- Studies on reconstitution of bovine erythrocyte superoxide-dismutase .5. Preparation and properties of derivatives in which both zinc and copper sites contain copper Academic Article
- Studies on the mechanism of enzymatic DNA elongation by Escherichia coli DNA polymerase II Academic Article
- Studies on the structure of nadh-ubiquinone oxidoreductase complex - topography of the subunits of the iron-sulfur flavoprotein component Academic Article
- Study of redox reactions of biological importance between fe(iii) complexes and aromatic moieties Academic Article
- Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP Academic Article
- Subdomain chimeras of hepatic lipase and lipoprotein lipase - localization of heparin and cofactor binding Academic Article
- Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065 Academic Article
- Substituting c-jun n-terminal kinase-3 (jnk3) atp-binding site amino acid residues with their p38 counterparts affects binding of jnk- and p38-selective inhibitors Academic Article
- Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes Academic Article
- Substrate recognition and catalysis by flap endonucleases and related enzymes Academic Article
- Substrate recognition, protein dynamics, and iron-sulfur cluster in Pseudomonas aeruginosa adenosine 5'-phosphosulfate reductase Academic Article
- Substrate specificities of two tau class glutathione transferases inducible by 2,4,6-trinitrotoluene in poplar Academic Article
- Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ Academic Article
- Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase Academic Article
- Subtle atomic group discrimination in the RNA minor groove Academic Article
- Subunit composition and domain-structure of the spo0a sporulation transcription factor of bacillus-subtilis Academic Article
- Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors Academic Article
- Sulfatases: Structure, mechanism, biological activity, inhibition, and synthetic utility Academic Article
- Sulfated blood-group lewis(a) - a superior oligosaccharide ligand for human e-selectin Academic Article
- Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor Academic Article
- Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin Academic Article
- Sulfite reductase structure at 1.6 Å - evolution and catalysis for reduction of inorganic anions Academic Article
- Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90 Academic Article
- Supercomputer-Based Ensemble Docking Drug Discovery Pipeline with Application to Covid-19 Academic Article
- Superoxide-dismutase - examination of the metal-binding sites by electron-spin echo spectroscopy Academic Article
- Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130 Academic Article
- Surface markers on human b-lymphocytes and t-lymphocytes .9. 2-color immunofluorescence studies on association between ebv receptors and complement receptors on surface of lymphoid-cell lines Academic Article
- Symmetrical stabilization of bound Ca2+ ions in a cooperative pair of EF-hands through hydrogen bonding of coordinating water molecules in calbindin D-9k Academic Article
- Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1 Academic Article
- Synergistic activation of transcription by physiologically unrelated transcription factors through cooperative DNA-binding Academic Article
- Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast Academic Article
- Synergy of NMR, computation, and x-ray crystallography for structural biology Academic Article
- Synergy of silent and hot spot mutations in importin beta reveals a dynamic mechanism for recognition of a nuclear localization signal Academic Article
- Synthesis and activity of new aryl- and heteroaryl- substituted pyrazole inhibitors of the transforming growth factor-βtype I receptor kinase domain Academic Article
- Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors Academic Article
- Synthesis and applications of a deep, asymmetric cavitand on a solid support Academic Article
- Synthesis and biological activity of a bivalent nucleotide inhibitor of ribonucleotide reductase Academic Article
- Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R) Academic Article
- Synthesis and evaluation of 1-(substituted)-3-prop-2-ynylureas as antiangiogenic agents Academic Article
- Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors Academic Article
- Synthesis and evaluation of deglycobleomycin A(2) analogues containing a tertiary N-methyl amide and simple ester replacement for the L-histidine secondary amide: Direct functional characterization of the requirement for secondary amide metal complexation Academic Article
- Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenyl sulfate and cyclic phenyl sulfamate motifs Academic Article
- Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid Academic Article
- Synthesis and evaluation of potential N-pi and N-sigma metal chelation sites within the beta-hydroxy-L-histidine subunit of bleomycin A(2): Functional characterization of imidazole N-pi metal complexation Academic Article
- Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase Academic Article
- Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA Academic Article
- Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid Academic Article
- Synthesis of key analogs of bleomycin A(2) that permit a systematic evaluation of the linker region - identification of an exceptionally prominent role for the L-threonine substituent Academic Article
- Synthesis of key sandramycin analogs: Systematic examination of the intercalation chromophore Academic Article
- Synthesis of nitric oxide by the nos-like protein from deinococcus radiodurans: A direct role for tetrahydrofolate Academic Article
- Synthesis of oligomeric mannosides and their structure-binding relationship with concanavalin A Academic Article
- Synthesis of potent bicyclic bisarylimidazole c-jun N-terminal kinase inhibitors by catalytic C-H bond activation Academic Article
- Synthesis of programmable integrases Academic Article
- Synthesis of sesquiterpene-inspired derivatives designed for covalent binding and their inhibition of the NF-κB pathway Academic Article
- Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers Academic Article
- Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents Academic Article
- Synthesis, properties, and applications of diazotrifluropropanoyl-containing photoactive analogs of farnesyl diphosphate containing modified linkages for enhanced stability Academic Article
- Synthetic seleno-glutaredoxin 3 analogues are highly reducing oxidoreductases with enhanced catalytic efficiency Academic Article
- T-antigen binds to simian virus-40 DNA at origin of replication Academic Article
- T-cell antigen receptor-binding sites for the microbial superantigen staphylococcal enterotoxin-a Academic Article
- T-cell receptor beta-chain binding to enterotoxin superantigens Academic Article
- T-cell receptor structure and tcr complexes Academic Article
- Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade Academic Article
- Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders Academic Article
- Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities Academic Article
- Targeted isolation of antibodies directed against major sites of SIV Env vulnerability Academic Article
- Targeting a pneumocystis carinii group i intron with methylphosphonate oligonucleotides: Backbone charge is not required for binding or reactivity Academic Article
- Targeting of t lymphocytes to melanoma cells through chimeric anti-gd3 immunoglobulin t-cell receptors Academic Article
- Targeting renal cell carcinoma with a HIF-2 antagonist Academic Article
- Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening Academic Article
- Terminal sialic acids on CD44 N-glycans can block hyaluronan binding by forming competing intramolecular contacts with arginine sidechains Academic Article
- Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment Academic Article
- Tertiary structure stabilization promotes hairpin ribozyme ligation Academic Article
- Tethering identifies fragment that yields potent inhibitors of human caspase-1 Academic Article
- Tethering small molecules to a phage display library: discovery of a selective bivalent inhibitor of protein kinase A Academic Article
- Tetrahydrobiopterin radical enzymology Academic Article
- The 0.78 Å structure of a serine protease: Bacillus lentus subtilisin Academic Article
- The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site Academic Article
- The 150-loop restricts the host specificity of human H10N8 influenza virus Academic Article
- The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist Academic Article
- The 2002 Bernard B. Brodie Award Lecture: Deciphering substrate recognition by drug-metabolizing cytochromes P450 Academic Article
- The 3.2 A resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays Academic Article
- The 5S gene internal control region is B-form both free in solution and in a complex with TFIIIA Academic Article
- The C2A domain of JFC1 binds to 3 '-phosphorylated phosphoinositides and directs plasma membrane association in living cells Academic Article
- The Caenorhabditis elegans unc-13 gene product is a phospholipid-dependent high-affinity phorbol ester receptor Academic Article
- The DNA repair endonuclease xpg interacts directly and functionally with the wrn helicase defective in werner syndrome Academic Article
- The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription Academic Article
- The EF-hand domain: a globally cooperative structural unit Academic Article
- The LG3 module of laminin-5 harbors a binding site for integrin α3β1 that promotes cell adhesion, spreading, and migration Academic Article
- The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments Academic Article
- The N-terminal nuclear localization sequences of liver X receptors α and β bind to importin α and are essential for both nuclear import and transactivating functions Academic Article
- The ND1 subunit constructs the inhibitor binding domain in bovine heart mitochondrial complex I Academic Article
- The NMR structure of cyclosporine-a bound to cyclophilin in aqueous-solution Academic Article
- The NMR structure of the activation domain isolated from porcine procarboxypeptidase-b Academic Article
- The NS5A protein of bovine viral diarrhea virus contains an essential zinc-binding site similar to that of the hepatitis C virus NS5A protein Academic Article
- The NS5A protein of hepatitis C virus is a zinc metalloprotein Academic Article
- The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit Academic Article
- The PAI-1/vitronectin interaction: two cats in a bag? Academic Article
- The RCSB Protein Data Bank: views of structural biology for basic and applied research and education Academic Article
- The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2 Academic Article
- The VEGF IRESes are differentially susceptible to translation inhibition by miR-16 Academic Article
- The X-ray crystal structure of the human mono-oxygenase cytochrome P450 3A5-ritonavir complex reveals active site differences between P450s 3A4 and 3A5 Academic Article
- The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways Academic Article
- The action of cardiolipin on the bacterial translocon Academic Article
- The active site of staphylococcal nuclease: paramagnetic relaxation of bound nucleotide inhibitor nuclei by lanthanide ions Academic Article
- The active-site residue Tyr-175 in human glyoxalase II contributes to binding of glutathione derivatives Academic Article
- The amino-terminus of the human c5a receptor is required for high-affinity c5a binding and for receptor activation by c5a but not c5a analogs Academic Article
- The antibody problem Academic Article
- The antitumor agent cc-1065 inhibits helicase-catalyzed unwinding of duplex DNA Academic Article
- The anxiolytic-like effects of the neurosteroid allopregnanolone: Interactions with gaba(a) receptors Academic Article
- The artt motif and a unified structural understanding of substrate recognition in adp-ribosylating bacterial toxins and eukaryotic adp-ribosyltransferases Academic Article
- The assignment of an exchangeable low-field NH proton resonance of ribonuclease A to the active-site histidine-119 Academic Article
- The association of the c7 allotype of rabbits with some light polypeptide chains which lack b locus allotypy Academic Article
- The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites Academic Article
- The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50 Academic Article
- The beta-2-adrenergic receptors of human epidermoid carcinoma-cells bear 2 different types of oligosaccharides which influence expression on the cell-surface Academic Article
- The binding of substrates and a product of the enzymatic reaction to glutathione S-transferase A Academic Article
- The biologic activity of the immunoregulatory lipoprotein, ldl-in, is independent of its free fatty-acid content Academic Article
- The c-terminal domain of yeast pcna is required for physical and functional interactions with cdc9 DNA ligase Academic Article
- The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition Academic Article
- The catalytic site of cytochrome P4504A11 (CYP4A11) and its L131F mutant Academic Article
- The cell-binding domains of plasminogen and their function in plasma Academic Article
- The chemistry of the antibody molecule Academic Article
- The client protein p53 adopts a molten globule-like state in the presence of hsp90 Academic Article
- The conserved KMN network constitutes the core microtubule-binding site of the kinetochore Academic Article
- The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation Academic Article
- The cooh terminus of aminoglycoside phosphotransferase (3 ')-iiia is critical for antibiotic recognition and resistance Academic Article
- The core meiotic transcriptome in budding yeasts Academic Article
- The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase Academic Article
- The covalent and three-dimensional structure of concanavalin a Academic Article
- The covalent structure of a human gamma G-immunoglobulin. XI. Functional implications Academic Article
- The croonian lecture 2000. Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission Academic Article
- The crystal structure of a novel bacterial adenylyltransferase reveals half of sites reactivity Academic Article
- The crystal structure of avian cd1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian cd1 Academic Article
- The crystal structure of human Argonaute2 Academic Article
- The crystal structure of the Helicobacter pylori LlaJI.R1 N-terminal domain provides a model for site-specific DNA binding Academic Article
- The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function Academic Article
- The crystal structure of the human DNA repair endonuclease hap1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites Academic Article
- The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity Academic Article
- The crystal structures of chloramphenicol phosphotransferase reveal a novel inactivation mechanism Academic Article
- The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism Academic Article
- The cytoplasmic tall peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein Academic Article
- The delta subunit of AP-3 is required for efficient transport of VSV-G from the trans-Golgi network to the cell surface Academic Article
- The design and synthesis of novel alpha-ketoamide-based p38 map kinase inhibitors Academic Article
- The dynamic energy landscape of dihydrofolate reductase catalysis Academic Article
- The effect of ribosome assembly cofactors on in vitro 30S subunit reconstitution Academic Article
- The evi-1 zinc-finger myeloid transforming protein binds to genomic fragments containing (gata)(n) sequences Academic Article
- The evolution of cefotaximase activity in the TEM β-lactamase Academic Article
- The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro Academic Article
- The gal4 activation domain binds sug2 protein, a proteasome component, in vivo and in vitro Academic Article
- The geminivirus nuclear shuttle protein is a virulence factor that suppresses transmembrane receptor kinase activity Academic Article
- The gene of chicken axonin-1. Complete structure and analysis of the promoter Academic Article
- The generation of stable cho-cell lines expressing very high-levels of complement c5a receptors and subsequent modulation of binding-affinity for c5a Academic Article
- The growth-promoting activity of the bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3 Academic Article
- The high activity of rat glutathione transferase 8-8 with alkene substrates is dependent on a glycine residue in the active site Academic Article
- The high resolution crystal structure of green abalone sperm lysin: Implications for species-specific binding of the egg receptor Academic Article
- The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme Academic Article
- The homeobox transcription factor Barx2 regulates chondrogenesis during limb development Academic Article
- The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells Academic Article
- The human retinoblastoma susceptibility gene promoter is positively autoregulated by its own product Academic Article
- The identification of metal-binding ligand residues in metalloproteins using nuclear magnetic resonance spectroscopy Academic Article
- The immunological evolution of catalysis Academic Article
- The importance of ligand-receptor conformational pairs in stabilization: spotlight on the N/OFQ G protein-coupled receptor Academic Article
- The importance of thiol- and disulfide groups in agonist and antagonist binding to the muscarinic receptor Academic Article
- The infectivity and host range of the ecotropic porcine endogenous retrovirus, perv-c, is modulated by residues in the c-terminal region of its surface envelope protein Academic Article
- The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin Academic Article
- The internal ribosome entry site (ires) contained within the rna-binding motif protein 3 (rbm3) mrna is composed of functionally distinct elements Academic Article
- The kinetics of nucleated polymerizations at high concentrations: Amyloid fibril formation near and above the "supercritical concentration'' Academic Article
- The kringle V-protease domain is a fibrinogen binding region within apo(a) Academic Article
- The lef-1 high-mobility group domain undergoes a disorder-to-order transition upon formation of a complex with cognate DNA Academic Article
- The leu-enkephalin-encoding sequence DNA-binding factor (lef) is the transcription factor yy1 Academic Article
- The leukocyte cell-surface receptor(s) for the ic3b product of complement Academic Article
- The maize (Zea mays L.) nucleoside diphosphate kinase1 (ZmNDPK1) gene encodes a human NM23-H2 homologue that binds and stabilizes G-quadruplex DNA Academic Article
- The major nuclear envelope targeting domain of lap2 coincides with its lamin binding region but is distinct from its chromatin interaction domain Academic Article
- The making of a phage Academic Article
- The modular character of a DNA junction-resolving enzyme - a zinc-binding motif in bacteriophage-T4 endonuclease-VII Academic Article
- The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins Academic Article
- The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule Academic Article
- The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K Academic Article
- The molecular perspective: Methotrexate Academic Article
- The nadh-binding subunit of the energy-transducing nadh-ubiquinone oxidoreductase of paracoccus-denitrificans - gene cloning and deduced primary structure Academic Article
- The nature of the enzymatic reduction of the mixed disulfide of coenzyme A and glutathione Academic Article
- The nh2-terminal region of apolipoprotein b is sufficient for lipoprotein association with glycosaminoglycans Academic Article
- The nuclear-magnetic-resonance solution structure of the mixed disulfide between escherichia-coli glutaredoxin(c14s) and glutathione Academic Article
- The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathway Academic Article
- The oncogenic potential of the high mobility group box protein sox3 Academic Article
- The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger Academic Article
- The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs Academic Article
- The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster Academic Article
- The proton-translocating nadh-quinone oxidoreductase (ndh-1) of thermophilic bacterium thermus thermophilus hb-8 - complete DNA sequence of the gene cluster and thermostable properties of the expressed nq02 subunit Academic Article
- The rad50 signature motif: Essential to atp binding and biological function Academic Article
- The rad50 zinc-hook is a structure joining mre11 complexes in DNA recombination and repair Academic Article
- The recognition of H-2 and viral antigens by cytotoxic T cells Academic Article
- The reduced, denatured somatomedin B domain of vitronectin refolds into a stable, biologically active molecule Academic Article
- The regulatory regions of the rice tungro bacilliform virus promoter and interacting nuclear factors in rice (Oryza sativa L.) Academic Article
- The relationship between structure and function for the sulfite reductases Academic Article
- The retinoblastoma susceptibility gene-product represses transcription when directly bound to the promoter Academic Article
- The rice phytochrome gene: structure, autoregulated expression, and binding of GT-1 to a conserved site in the 5' upstream region Academic Article
- The role of arginine-143 in the electrostatics and mechanism of Cu,Zn superoxide-dismutase - computational and experimental evaluation by mutational analysis Academic Article
- The role of dynamic conformational ensembles in biomolecular recognition Academic Article
- The roles of S1 RNA-binding domains in Rrp5's interactions with pre-rRNA Academic Article
- The second receptor binding site of the globular head of the newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion Academic Article
- The self-inhibited structure of full-length PCSK9 at 1.9 Å reveals structural homology with resistin within the C-terminal domain Academic Article
- The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope Academic Article
- The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle Academic Article
- The sialyltransferase sialylmotif participates in binding the donor substrate cmp-neuac Academic Article
- The sigma(1) (sigma(1)) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming Academic Article
- The small nuclear ribonucleoprotein SS-B/La binds RNA with a conserved protease-resistant domain of 28 kilodaltons Academic Article
- The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML Academic Article
- The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor Academic Article
- The structural basis for biphasic kinetics in the folding of the WW domain from a formin-binding protein: lessons for protein design? Academic Article
- The structural basis for in situ activation of DNA alkylation by duocarmycin sa Academic Article
- The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae Academic Article
- The structural basis of recognition and removal of cellular mrna 7-methyl g 'caps' by a viral capsid protein: A unique viral response to host defense Academic Article
- The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability Academic Article
- The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type iiptrases Academic Article
- The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0 Å resolution Academic Article
- The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05 Å resolution Academic Article
- The structure of jnk3 in complex with small molecule inhibitors: Structural basis for potency and selectivity Academic Article
- The structure of nitric oxide synthase oxygenase domain and inhibitor complexes Academic Article
- The structure of the crispr-associated protein csa3 provides insight into the regulation of the crispr/cas system Academic Article
- The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex Academic Article
- The structure of the yeast nadh dehydrogenase (ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates Academic Article
- The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif Academic Article
- The tau-4 activation domain of the thyroid-hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing Academic Article
- The theoretical limits of DNA sequence discrimination by linked polyamides Academic Article
- The thermotoga maritima trk potassium transporter-from frameshift to function Academic Article
- The third Trp-Lys-Ser (WKS) tripeptide motif in tissue factor is associated with a function site Academic Article
- The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli Academic Article
- The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis Academic Article
- The transcriptional control of the perforin locus Academic Article
- The transition-state regulator hpr of bacillus-subtilis is a DNA-binding protein Academic Article
- The transition-state transcription regulator abrb of bacillus-subtilis is a DNA-binding protein Academic Article
- The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire Academic Article
- The usher syndrome proteins cadherin 23 and harmonin form a complex by means of pdz-domain interactions Academic Article
- The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin Academic Article
- The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments Academic Article
- The way things move: Looking under the hood of molecular motor proteins Academic Article
- Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin Academic Article
- Thermodynamic analysis of purified human placental alpha-l-fucosidase Academic Article
- Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase Academic Article
- Thermodynamics of RNA-RNA duplexes with 2-or 4-thiouridines: implications for antisense design and targeting a group I intron Academic Article
- Thiol ligation of two zinc atoms to a class I tRNA synthetase: evidence for unshared thiols and role in amino acid binding and utilization Academic Article
- Thioredoxin catalyzes the s-nitrosation of the caspase-3 active site cysteine Academic Article
- Three pairs of cysteine residues mediate both redox and Zn2+ modulation of the NMDA receptor Academic Article
- Three photo-cross-linked complexes of yeast phenylalanine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases Academic Article
- Three-dimensional EM structure of the ectodomain of integrin alpha V beta 3 in a complex with fibronectin Academic Article
- Three-dimensional location of the main immunogenic region of the acetylcholine receptor Academic Article
- Three-dimensional model of membrane-bound ribosomes obtained by electron microscopy Academic Article
- Three-dimensional model of the human platelet integrin alpha(llb)beta(3) based on electron cryomicroscopy and x-ray crystallography Academic Article
- Three-dimensional solution structure of a single zinc finger DNA-binding domain Academic Article
- Three-dimensional solution structure of the reduced form of Escherichia coli thioredoxin determined by nuclear magnetic resonance spectroscopy Academic Article
- Three-dimensional structure of brush border myosin-i at similar to 20 Å resolution by electron microscopy and image analysis Academic Article
- Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Academic Article
- Tissue factor - molecular recognition and cofactor function Academic Article
- Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity Academic Article
- Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta(3) subunit Academic Article
- Topography of the high-affinity lysine binding site of plasminogen as defined with a specific antibody probe Academic Article
- Total syntheses and initial evaluation of [?[C(-S)NH]Tpg(4)]vancomycin, [?[C(-NH)NH]Tpg(4)]vancomycin, [?[CH2NH]Tpg(4)]vancomycin, and their (4-Chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptide antibiotics Academic Article
- Total synthesis of Psi C(=NH)NH Tpg(4) vancomycin and its ((4)-chlorobiphenyl)methyl derivative: impact of peripheral modifications on vancomycin analogues redesigned for dual D-Ala-D-Ala and D-Ala-D-Lac binding Academic Article
- Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5 '-gnn-3 ' DNA target sequences Academic Article
- Toward understanding the structural basis of partial agonism at the dopamine D-3 receptor Academic Article
- Transcript leader regions of two saccharomyces cerevisiae mrnas contain internal ribosome entry sites that function in living cells Academic Article
- Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)to-DJ(H) rearrangement of immunoglobulin genes Academic Article
- Transcription inactivation through local refolding of the RNA polymerase structure Academic Article
- Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9 Academic Article
- Transcriptional regulation of BCL-2 by nuclear factor kappa B and its significance in prostate cancer Academic Article
- Transcriptional regulation of the mouse fatty acid amide hydrolase gene Academic Article
- Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis Academic Article
- Transfer RNA: from minihelix to genetic code Academic Article
- Transfer of flexibility between ankyrin repeats in i kappa b alpha upon formation of the nf-kappa b complex Academic Article
- Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase Academic Article
- Trapping and characterization of novel retinoid response elements Academic Article
- Trapping the dynamic acyl carrier protein in fatty acid biosynthesis Academic Article
- Trial for peptide bond formation using model molecules based on the interactions between the CCA sequence of tRNA and 23S rRNA Academic Article
- Tropomodulin binds to filensin intermediate filaments Academic Article
- Tropomodulin contains two actin filament pointed end-capping domains Academic Article
- Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin Academic Article
- Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein Academic Article
- Two classes of binding sites for uncoating protein in clathrin triskelions Academic Article
- Two classes of cholesterol binding sites for the β2AR revealed by thermostability and NMR Academic Article
- Two classes of tRNA synthetases suggested by sterically compatible dockings on tRNA acceptor stem Academic Article
- Two estrogen receptors in reproductive tissue Academic Article
- Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency Academic Article
- Two ligands may bind simultaneously to the muscarine receptor Academic Article
- Two mutations in the promoter region of the human protein-C gene both cause type-I protein-C deficiency by disruption of 2 HNF-3 binding-sites Academic Article
- Two photo-cross-linked complexes of isoleucine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases Academic Article
- Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa Academic Article
- Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides Academic Article
- Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines Academic Article
- Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors Academic Article
- Type-III omega-agatoxins - a family of probes for similar binding-sites on L-type and N-type calcium channels Academic Article
- Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2 '-deoxyuridine 5 '-monophosphate Academic Article
- Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120 Academic Article
- Uba domains mediate protein-protein interactions between two DNA damage-inducible proteins Academic Article
- Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2 Academic Article
- Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates Academic Article
- Ubiquitylation of cyclin e requires the sequential function of scf complexes containing distinct hcdc4 isoforms Academic Article
- Understanding the enzymatic activity of 4-oxalocrotonate tautomerase and its mutant analogues: A computational study Academic Article
- Understanding the recognition of transfer RNAs by aminoacyl transfer RNA synthetases Academic Article
- Unexpected acetylcholinesterase activity of cocaine esterases Academic Article
- Unexpected ca2+-binding properties of synaptotagmin 9 Academic Article
- Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase Academic Article
- Unique interactions of asialo von Willebrand factor with platelets in platelet-type von Willebrand disease Academic Article
- Unmasking of CD22 co-receptor on germinal center B-cells occurs by alternative mechanisms in mouse and man Academic Article
- Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease iv Academic Article
- Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein lb Academic Article
- Upstream activation sequence-dependent alteration of chromatin structure and transcription activation of the yeast GAL1-GAL10 genes Academic Article
- Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects Academic Article
- Use of phage display and transition-state analogs to select enzyme variants with altered catalytic properties: Glutathione transferase as an example Academic Article
- Use of sialic-acid analogs to define functional-groups involved in binding to the influenza-virus hemagglutinin Academic Article
- Using AutoDock for ligand-receptor docking Academic Article
- Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task Academic Article
- Using the process of reactive immunization to induce catalytic antibodies with complex mechanisms: Aldolases Academic Article
- Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: Murine alpha 8 beta 1 binds to the rgd site in tenascin-c fragments, but not to native tenascin-c Academic Article
- V-jun encodes a nuclear protein with enhancer binding properties of ap-1 Academic Article
- Vaccine elicitation of high mannose-dependent neutralizing antibodies against the V3-glycan broadly neutralizing epitope in nonhuman primates Academic Article
- Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign Academic Article
- Vaccine-elicited tier 2 HIV-1 neutralizing antibodies bind to quaternary epitopes involving glycan-deficient patches proximal to the CD4 binding site Academic Article
- Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention Academic Article
- Variable loop glycan dependency of the broad and potent hiv-1-neutralizing antibodies pg9 and pg16 Academic Article
- Variation and control of specific antigen-binding cell-populations in individual fetal mice Academic Article
- Vinculin binding in its closed conformation by a helix addition mechanism Academic Article
- Virtual screening against acetylcholine binding protein Academic Article
- Virtual screening against alpha-cobratoxin Academic Article
- Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors Academic Article
- Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challenge Academic Article
- Virus yoga: The role of flexibility in virus host cell recognition Academic Article
- Virus-induced immune complex disease: specific anti-viral antibody and C1q binding material in the circulation during persistent lymphocytic choriomeningitis virus infection Academic Article
- Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide Academic Article
- Voronoi binding site model of a polycyclic aromatic hydrocarbon binding protein Academic Article
- Water-soluble, recombinant cu-a-domain of the cytochrome ba(3) subunit ii from thermus thermophilus Academic Article
- What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands? Academic Article
- White matter NMDA receptors: an unexpected new therapeutic target? Academic Article
- Wrn exonuclease structure and molecular mechanism imply an editing role in DNA end processing Academic Article
- X-pro peptide-bond as an NMR probe for conformational studies of flexible linear peptides Academic Article
- X-ray absorption studies of the Zn2+ site of glyoxalase I Academic Article
- X-ray absorption studies of the copper-beta domain of rat-liver metallothionein Academic Article
- X-ray crystallographic determination of the structure of the influenza c virus haemagglutinin-esterase-fusion glycoprotein Academic Article
- X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus Academic Article
- X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease Academic Article
- X-ray structure of junctional adhesion molecule: Structural basis for homophilic adhesion via a novel dimerization motif Academic Article
- X-ray structure of metallothionein Academic Article
- X-ray structures of the LXRα LBD in its homodimeric form and implications for heterodimer signaling Academic Article
- Xyloglucan sidechains modulate binding to cellulose during in vitro binding assays as predicted by conformational dynamics simulations Academic Article
- Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway Academic Article
- Yeast glyoxalase I is a monomeric enzyme with two active sites Academic Article
- Yy1 binding to a subset of p53 DNA-target sites regulates p53-dependent transcription Academic Article
- ZiF-Predict: a web tool for predicting DNA-binding specificity in C2H2 zinc finger proteins Academic Article
- Zinc finger tools: Custom DNA-binding domains for transcription factors and nucleases Academic Article
- Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology Academic Article
- Zinc-dependent cell growth conferred by mutant tRNA synthetase Academic Article
- Zinc-dependent tRNA binding by a peptide element within a tRNA synthetase Academic Article
- Zinc-free and reduced t4 gene-32 protein binds single-stranded-DNA weakly and fails to stimulate uvsx-catalyzed homologous pairing Academic Article
- Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB Academic Article
- hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene Academic Article
- p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses Academic Article
- von Willebrand factor has more than one binding site for platelets Academic Article
- von Willebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism Academic Article
- γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin Academic Article