subject area of

• 1.35 and 2.07 a resolution structures of the red abalone sperm lysin monomer and dimer reveal features involved in receptor binding  Academic Article
• 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase  Academic Article
• 2,5-diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3)  Academic Article
• 2-(3,5-dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor  Academic Article
• 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport  Academic Article
• 3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting  Academic Article
• 3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle  Academic Article
• 3D domain swapping modulates the stability of members of an icosahedral virus group  Academic Article
• 4-Aminoindazolyl-dihydrofuro 3,4-d pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase  Academic Article
• A Disorder-to-Order Transition Activates an ATP-Independent Membrane Protein Chaperone  Academic Article
• A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs  Academic Article
• A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model  Academic Article
• A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis  Academic Article
• A base triple in the tetrahymena group i core affects the reaction equilibrium via a threshold effect  Academic Article
• A binding site for homeodomain and pax proteins is necessary for l1 cell adhesion molecule gene expression by pax-6 and bone morphogenetic proteins  Academic Article
• A binding site for pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord  Academic Article
• A branching reaction mechanism of glutathione reductase  Academic Article
• A brassinosteroid transcriptional network revealed by genome-wide identification of BESI target genes in Arabidopsis thaliana  Academic Article
• A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding  Academic Article
• A cell cycle phosphoproteome of the yeast centrosome  Academic Article
• A chemical, genetic, and structural analysis of the nuclear bile acid receptor fxr  Academic Article
• A chemically functionalized magnetic nanoplatform for rapid and specific biomolecular recognition and separation  Academic Article
• A chromatin binding-site in the tail domain of nuclear lamins that interacts with core histones  Academic Article
• A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease  Academic Article
• A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPAR gamma partial agonists  Academic Article
• A complex assembly landscape for the 30S ribosomal subunit  Academic Article
• A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis  Academic Article
• A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles  Academic Article
• A conserved hiv gp120 glycoprotein structure involved in chemokine receptor binding  Academic Article
• A conserved motif in the itk ph-domain is required for phosphoinositide binding and tcr signaling but dispensable for adaptor protein interactions  Academic Article
• A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase  Academic Article
• A de novo designed peptide ligase: A mechanistic investigation  Academic Article
• A de novo protein binding pair by computational design and directed evolution  Academic Article
• A density functional evaluation of an Fe(III)-Fe(IV) model diiron cluster: comparisons with ribonucleotide reductase intermediate X  Academic Article
• A designed inhibitor of a CLC antiporter blocks function through a unique binding mode  Academic Article
• A designed synthetic analogue of 4-OT is specific for a non-natural substrate  Academic Article
• A detailed structural model of cytotactin - protein homologies, alternative rna splicing, and binding regions  Academic Article
• A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons  Academic Article
• A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120  Academic Article
• A dynamic search process underlies microRNA targeting  Academic Article
• A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol)  Academic Article
• A flexible interface between DNA ligase and pcna supports conformational switching and efficient ligation of DNA  Academic Article
• A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking  Academic Article
• A four-helical super-secondary structure  Academic Article
• A fragment of human TrpRS as a potent antagonist of ocular angiogenesis  Academic Article
• A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia-coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases  Academic Article
• A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock  Academic Article
• A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding  Academic Article
• A g-protein alpha-subunit from asexual candida-albicans functions in the mating signal transduction pathway of saccharomyces-cerevisiae and is regulated by the a1-alpha-2 repressor  Academic Article
• A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain  Academic Article
• A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells  Academic Article
• A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans  Academic Article
• A genetically encoded diazirine photocrosslinker in Escherichia coli  Academic Article
• A genetically encoded fluorescent amino acid  Academic Article
• A global benchmark study using affinity-based biosensors  Academic Article
• A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728  Academic Article
• A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B  Academic Article
• A hierarchy of RNA subdomains in assembly of the central domain of the 30 S ribosomal subunit  Academic Article
• A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs  Academic Article
• A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV  Academic Article
• A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein  Academic Article
• A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS  Academic Article
• A linear amino acid sequence involved in the interaction of t-PA with its endothelial cell receptor  Academic Article
• A method for defining binding sites involved in protein-protein interactions: analysis of the binding of plasminogen activator inhibitor 1 to the somatomedin domain of vitronectin  Academic Article
• A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase  Academic Article
• A molecular switch regulating transcriptional repression and activation of PPARγ  Academic Article
• A mutation in the human cyclin-dependent kinase interacting protein, ckshs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly  Academic Article
• A new decoration for nitric oxide synthase - a zn(cys)4 site  Academic Article
• A new mechanism of allostery in a G protein-coupled receptor dimer  Academic Article
• A new model for binding of kinesin 13 to curved microtubule protofilaments  Academic Article
• A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic c-1027 biosynthesis  Academic Article
• A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A  Academic Article
• A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase  Academic Article
• A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties  Academic Article
• A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma  Academic Article
• A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va  Academic Article
• A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1  Academic Article
• A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex  Academic Article
• A novel role of the budding yeast separin esp1 in anaphase spindle elongation: Evidence that proper spindle association of esp1 is regulated by pds1  Academic Article
• A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity  Academic Article
• A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site  Academic Article
• A permutational approach toward protein-DNA recognition  Academic Article
• A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis  Academic Article
• A poly(A) binding protein functions in the chloroplast as a message-specific translation factor  Academic Article
• A positive feedback loop controls transcription of the spoof gene, a component of the sporulation phosphorelay in bacillus-subtilis  Academic Article
• A protein-S binding-site on C4b-binding protein involves beta-chain residues 31-45  Academic Article
• A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.Fem-3 mRNA complex  Academic Article
• A random walk in oncogene space: The quest for targets  Academic Article
• A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation  Academic Article
• A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin  Academic Article
• A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria  Academic Article
• A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: Crystal structure of spo0f from bacillus subtilis  Academic Article
• A retroviral-like metal binding motif in an aminoacyl-tRNA synthetase is important for tRNA recognition  Academic Article
• A reversible reaction inside a self-assembled capsule  Academic Article
• A ribozyme composed of only two different nucleotides  Academic Article
• A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus  Academic Article
• A role for ranbp1 in the release of crm1 from the nuclear pore complex in a terminal step of nuclear export  Academic Article
• A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280  Academic Article
• A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib  Academic Article
• A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis  Academic Article
• A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases  Academic Article
• A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta  Academic Article
• A semisynthetic glutathione peroxidase with high catalytic efficiency: Selenoglutathione transferase  Academic Article
• A shape-dependent hydrophobic effect for tetrazoles  Academic Article
• A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth  Academic Article
• A silencer element in the retinoblastoma tumor-suppressor gene  Academic Article
• A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity  Academic Article
• A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure  Academic Article
• A single gal4 dimer can maximally activate transcription under physiological conditions  Academic Article
• A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors  Academic Article
• A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases  Academic Article
• A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases  Academic Article
• A small molecule inhibitor selective for a variant atp-binding site of the chaperonin groel  Academic Article
• A source of response regulator autophosphatase activity: The critical role of a residue adjacent to the spo0f autophosphorylation active site  Academic Article
• A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor  Academic Article
• A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle  Academic Article
• A sphingosine 1-phosphate receptor 2 selective allosteric agonist  Academic Article
• A stapled p53 helix overcomes HDMX-mediated suppression of p53  Academic Article
• A steady-state kinetic model of butyrylcholinesterase from horse plasma  Academic Article
• A steady-state-kinetic random mechanism for glutathione S-transferase A from rat liver. A model involving kinetically significant enzyme-product complexes in the forward reaction  Academic Article
• A structural model for the high-valent intermediate Q of methane monooxygenase from broken-symmetry density functional and electrostatics calculations  Academic Article
• A structural model for the prostate disease marker, human prostate-specific antigen  Academic Article
• A structural perspective of the sequence variability within botulinum neurotoxin subtypes a1-a4  Academic Article
• A structure-activity study of nociceptin-(1-13)-peptide amide. Synthesis of analogues substituted in positions 0, 1, 3, 4 and 10  Academic Article
• A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase  Academic Article
• A synthetic receptor for phosphocholine esters  Academic Article
• A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease  Academic Article
• A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen  Academic Article
• A translation-like cycle is a quality control checkpoint for maturing 40s ribosome subunits  Academic Article
• A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5  Academic Article
• A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry  Academic Article
• A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin mac-1 (cd11b cd18)  Academic Article
• A universal entropy-driven mechanism for thioredoxin-target recognition  Academic Article
• A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities  Academic Article
• ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair  Academic Article
• ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization  Academic Article
• ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase  Academic Article
• Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: The 3 ' ends justify the means  Academic Article
• Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: Formation of a pterin radical is required for enzyme activity  Academic Article
• Ablating adenovirus type 5 fiber-car binding and hi loop insertion of the sigyplp peptide generate an endothelial cell-selective adenovirus  Academic Article
• Absence of G(i) proteins in the Sf9 insect cell. Characterization of the uncoupled recombinant N-formyl peptide receptor  Academic Article
• Acceptor helix interactions in a class II tRNA synthetase: photoaffinity cross-linking of an RNA miniduplex substrate  Academic Article
• Acceptor substrate-based selective inhibition of galactosyltransferases  Academic Article
• Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gpl120 is sterically restricted on primary human immunodeficiency virus type 1  Academic Article
• Accessibility of nuclear chromatin by DNA binding polyamides  Academic Article
• Acetylcholine recognition by a deep, biomimetic pocket  Academic Article
• Acidophilic adaptations in the structure of Acetobacter aceti N-5-carboxyaminoimidazole ribonucleotide mutase (PurE)  Academic Article
• Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements  Academic Article
• Activation of Hageman factor in solid and fluid phases. A critical role of kallikrein  Academic Article
• Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1  Academic Article
• Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete c-terminal domain  Academic Article
• Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the a subunits  Academic Article
• Activation of the redox-regulated chaperone hsp33 by domain unfolding  Academic Article
• Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation  Academic Article
• Active and alkylated human agt structures: A novel zinc site, inhibitor and extrahelical base binding  Academic Article
• Active and inhibited human catalase structures: Ligand and nadph binding and catalytic mechanism  Academic Article
• Active site binding modes of curcumin in HIV-1 protease and integrase  Academic Article
• Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense  Academic Article
• Active site modification of factor viia affects interactions of the protease domain with tissue factor  Academic Article
• Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein  Academic Article
• Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties  Academic Article
• Active site residues of cyclophilin A are crucial for its signaling activity via CD147  Academic Article
• Active site structure of Rieske-type proteins: electron nuclear double resonance studies of isotopically labeled phthalate dioxygenase from Pseudomonas cepacia and Rieske protein from Rhodobacter capsulatus and molecular modeling studies of a Rieske center  Academic Article
• Active site structure of class I ribonucleotide reductase intermediate X: a density functional theory analysis of structure, energetics, and spectroscopy  Academic Article
• Active site-directed inhibition of rabbit cytochrome P-450 1 by amino-substituted steroids  Academic Article
• Active thymus derived suppressor lymphocytes in human cord blood  Academic Article
• Active, interactive, and inactive steroid-receptor mutants  Academic Article
• Active-site and oligosaccharide recognition residues of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f  Academic Article
• Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3  Academic Article
• Activity-based protein profiling for the functional annotation of enzymes  Academic Article
• Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid)  Academic Article
• Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2  Academic Article
• Adding L-3-(2-naphthyl)alanine to the genetic code of E. coli  Academic Article
• Addition of an alpha-hydroxy acid to the genetic code of bacteria  Academic Article
• Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope  Academic Article
• Adenosine: a partial agonist of the growth hormone secretagogue receptor  Academic Article
• Adhesive properties of the isolated amino-terminal domain of platelet glycoprotein Ib alpha in a flow field  Academic Article
• Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenge  Academic Article
• Advances in pain therapeutics  Academic Article
• Affinity labeling of creatine kinase by N-(2,3-epoxypropyl)-N-amidinoglycine  Academic Article
• Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling  Academic Article
• Agonist-bound structure of the human P2Y(12) receptor  Academic Article
• Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence  Academic Article
• Alanine scanning mutagenesis of an alpha beta T cell receptor: mapping the energy of antigen recognition  Academic Article
• Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA  Academic Article
• Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition  Academic Article
• Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase  Academic Article
• Aldehyde dehydrogenase inhibitors: A comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application  Academic Article
• Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors  Academic Article
• Allosteric inhibition of hypoxia inducible factor-2 with small molecules  Academic Article
• Allosteric inhibition via R-state destabilization in ATP sulfurylase from Penicillium chrysogenum  Academic Article
• Alternative outcomes in assembly of promoter complexes: The roles of TBP and a flexible linker in placing TFIIIB on tRNA genes  Academic Article
• Amino acid derived quinazolines as Rock/PKA inhibitors  Academic Article
• Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles  Academic Article
• Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib  Academic Article
• Amino acid substitution at the dimeric interface of human manganese superoxide dismutase  Academic Article
• Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase  Academic Article
• Aminoacylation of RNA minihelices: implications for tRNA synthetase structural design and evolution  Academic Article
• Aminoglycoside binding in the major groove of duplex rna: The thermodynamic and electrostatic forces that govern recognition  Academic Article
• Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase  Academic Article
• An AP-1 site is involved in the NGF induction of IL-1α in PC12 cells  Academic Article
• An L-RNA aptamer that binds and inhibits RNase  Academic Article
• An NMR perspective on enzyme dynamics  Academic Article
• An RNA binding site in a tRNA synthetase with a reduced set of amino acids  Academic Article
• An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors  Academic Article
• An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide  Academic Article
• An acyloxymethyl ketone-based probe to monitor the activity of glutathionylspermidine amidase in Escherichia coli  Academic Article
• An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1  Academic Article
• An alternate binding site for PPARγ ligands  Academic Article
• An alternative processing of integrin αv subunit in tumor cells by membrane type-1 matrix metalloproteinase  Academic Article
• An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance  Academic Article
• An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode  Academic Article
• An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription  Academic Article
• An analysis of a class of DNA sequence reading molecules  Academic Article
• An aptamer that neutralizes r5 strains of hiv-1 binds to core residues of gp120 in the ccr5 binding site  Academic Article
• An aptamer that neutralizes r5 strains of human immunodeficiency virus type 1 blocks gp120-ccr5 interaction  Academic Article
• An engineered mutant of hiv-1 gp120 formulated with adjuvant quil a promotes elicitation of antibody responses overlapping the cd4-binding site  Academic Article
• An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured  Academic Article
• An essential histidine residue in the catalytic mechanism of mammalian glutathione reductase  Academic Article
• An essential role for the conserved Glu-133 in the anion interaction with superoxide-dismutase  Academic Article
• An evolutionary approach to the design of glutathione-linked enzymes  Academic Article
• An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity  Academic Article
• An improved zinc-finger nuclease architecture for highly specific genome editing  Academic Article
• An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation  Academic Article
• An inhibitor of sequence-specific proteolysis that targets the substrate rather than the enzyme  Academic Article
• An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity  Academic Article
• An intramolecular signaling element that modulates dynamin function in vitro and in vivo  Academic Article
• An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin 5  Academic Article
• An o-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses  Academic Article
• An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution  Academic Article
• An operational RNA code for amino acids and variations in critical nucleotide sequences in evolution  Academic Article
• An oxetane-based polyketide surrogate To probe substrate binding in a polyketide synthase  Academic Article
• An unusual dimeric structure and assembly for tlr4 regulator rp105-md-1  Academic Article
• Analysis of bacteriophage N protein and peptide binding to boxB RNA using polyacrylamide gel coelectrophoresis (PACE)  Academic Article
• Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes  Academic Article
• Analysis of hapten binding and catalytic determinants in a family of catalytic antibodies  Academic Article
• Analysis of structure-function relationships in the platelet membrane glycoprotein Ib-binding domain of von Willebrand's factor by expression of deletion mutants  Academic Article
• Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo  Academic Article
• Analysis of the class i aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99 Å resolution  Academic Article
• Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity  Academic Article
• Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera  Academic Article
• Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: Insight into the chaotrope unfolding dichotomy  Academic Article
• Anisotropic molecular rotational diffusion in n-15 spin relaxation studies of protein mobility  Academic Article
• Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists  Academic Article
• Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres  Academic Article
• Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones  Academic Article
• Anti-diabetic drug binding site in a mammalian K-ATP channel revealed by Cryo-EM  Academic Article
• Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen  Academic Article
• Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides  Academic Article
• Antibodies raised against beta-adrenergic receptors stimulate adenylate-cyclase  Academic Article
• Antibody 2g12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the hiv-1 glycan shield if domain exchanged  Academic Article
• Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike  Academic Article
• Antibody binding defines a structure for an epitope that participates in the prpc -> prpsc conformational change  Academic Article
• Antibody catalysis of the oxidation of water  Academic Article
• Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics  Academic Article
• Antibody microarrays utilizing site-specific antibody-oligonucleotide conjugates  Academic Article
• Antibody neutralization epitopes and integrin binding sites on nonenveloped viruses  Academic Article
• Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env  Academic Article
• Antibody structure and molecular immunology  Academic Article
• Antibody structure, diversity, and specificity  Academic Article
• Antibody vs. HIV in a clash of evolutionary titans  Academic Article
• Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions  Academic Article
• Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation  Academic Article
• Anticodon G recognition by tRNA synthetases mimics the tRNA core  Academic Article
• Antifungal azoles: structural insights into undesired tight binding to cholesterol-metabolizing CYP46A1  Academic Article
• Antigen recognition by variable lymphocyte receptors  Academic Article
• Antiidiotype and antihormone receptor antibodies  Academic Article
• Antimitotic agents of natural origin  Academic Article
• Ap-2/eps15 interaction is required for receptor-mediated endocytosis  Academic Article
• Apo raver1 structure reveals distinct RRM domain orientations  Academic Article
• Application of nuclear magnetic-resonance spectroscopy to proteins  Academic Article
• Approaches toward selective inhibition of nitric oxide synthase  Academic Article
• Aptly named aptamers display their aptitude  Academic Article
• Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation  Academic Article
• Archaeal flagellar atpase motor shows atp-dependent hexameric assembly and activity stimulation by specific lipid binding  Academic Article
• Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors  Academic Article
• Architecture of the mediator head module  Academic Article
• Arginine-54 in the active-site of escherichia-coli aspartate transcarbamoylase is critical for catalysis - a site-specific mutagenesis, NMR, and x-ray crystallographic study  Academic Article
• Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions  Academic Article
• Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor  Academic Article
• Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein  Academic Article
• Aspartate-transcarbamylase lacking catalytic subunit interactions - study of conformational-changes by uv absorbance and circular-dichroism spectroscopy  Academic Article
• Aspects of the molecular-structure of igg subclasses  Academic Article
• Assembly of hybrid bacteriophage Qβ virus-like particles  Academic Article
• Assembly of the ebola virus nucleoprotein from a chaperoned VP35 complex  Academic Article
• Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure  Academic Article
• Assessment of major and minor groove DNA interactions by the zinc fingers of xenopus transcription factor IIIA  Academic Article
• Association of Sindbis virus capsid protein with phospholipid membranes and the E2 glycoprotein: implications for alphavirus assembly  Academic Article
• Association of plasma apolipoproteins d with rbc membrane arachidonic acid levels in schizophrenia  Academic Article
• Association of the cytoplasmic domain of intercellular-adhesion molecule-1 with glyceraldehyde-3-phosphate dehydrogenase and beta-tubulin  Academic Article
• Asymmetric DNA binding by a homodimeric bHLH protein  Academic Article
• Asymmetric organic synthesis with catalytic antibodies  Academic Article
• Atomic and residue hydrophilicity in the context of folded protein structures  Academic Article
• Atomic coordinates and molecular-conformation of yeast phenylalanyl transfer-rna - independent investigation  Academic Article
• Atomic coordinates for triose phosphate isomerase from chicken muscle  Academic Article
• Atp induces conformational changes in the carboxyl-terminal region of clc-5  Academic Article
• Attachment of ribosome crystals to intracellular membranes  Academic Article
• Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor  Academic Article
• AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading  Academic Article
• AutoDock4(Zn): an improved AutoDock force field for small-molecule docking to zinc metalloproteins  Academic Article
• AutoDockFR: Advances in protein-ligand docking with explicitly specified binding site flexibility  Academic Article
• Autoactivation of avian urokinase-type plasminogen activator (upa) - a novel mode of initiation of the upa/plasmin cascade  Academic Article
• Automated docking in crystallography: analysis of the substrates of aconitase  Academic Article
• Automated docking of ligands to an artificial active site: augmenting crystallographic analysis with computer modeling  Academic Article
• Automated docking of substrates to proteins by simulated annealing  Academic Article
• Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase  Academic Article
• Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications  Academic Article
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• Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity  Academic Article
• Crystal structure of a lipid G protein-coupled receptor  Academic Article
• Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity  Academic Article
• Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution  Academic Article
• Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch  Academic Article
• Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design  Academic Article
• Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design  Academic Article
• Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 Å resolution  Academic Article
• Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 Å resolution  Academic Article
• Crystal structure of a phosphatase-resistant mutant of sporulation response regulator spo0f from bacillus subtilis  Academic Article
• Crystal structure of a putative NADPH-dependent oxidoreductase (GI : 18204011) from mouse at 2.10 Å resolution  Academic Article
• Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 Å resolution  Academic Article
• Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 a resolution  Academic Article
• Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3  Academic Article
• Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 Å resolution  Academic Article
• Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design  Academic Article
• Crystal structure of an isolated V(alpha) domain of the 2C T-cell receptor  Academic Article
• Crystal structure of antagonist bound human lysophosphatidic acid receptor 1  Academic Article
• Crystal structure of atp sulfurylase from penicillium chrysogenum: Insights into the allosteric regulation of sulfate assimilation  Academic Article
• Crystal structure of botulinum neuro-toxin type a and implications for toxicity  Academic Article
• Crystal structure of botulinum neurotoxin type g light chain: Serotype divergence in substrate recognition  Academic Article
• Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5  Academic Article
• Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition  Academic Article
• Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping  Academic Article
• Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue  Academic Article
• Crystal structure of human ornithine transcarbamylase complexed with carbamoyl phosphate and L-norvaline at 1.9 A resolution  Academic Article
• Crystal structure of human toll-like receptor 3 (tlr3) ectodomain  Academic Article
• Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites  Academic Article
• Crystal structure of human vinculin  Academic Article
• Crystal structure of misoprostol bound to the labor inducer prostaglandin E-2 receptor  Academic Article
• Crystal structure of mouse cd1: An mhc-like fold with a large hydrophobic binding groove  Academic Article
• Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 Å-resolution  Academic Article
• Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser  Academic Article
• Crystal structure of soluble md-1 and its interaction with lipid iva  Academic Article
• Crystal structure of the 100 kda arsenite oxidase from alcaligenes faecalis in two crystal forms at 1.64 Å and 2.03 Å  Academic Article
• Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution  Academic Article
• Crystal structure of the Frizzled 4 receptor in a ligand-free state  Academic Article
• Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose  Academic Article
• Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide  Academic Article
• Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran  Academic Article
• Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding  Academic Article
• Crystal structure of the broadly cross-reactive hiv-1-neutralizing fab x5 and fine mapping of its epitope  Academic Article
• Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin a  Academic Article
• Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a k(+) channel inhibitor-like fold  Academic Article
• Crystal structure of the human 4-1BB/4-1BBL complex  Academic Article
• Crystal structure of the human TRPV2 channel ankyrin repeat domain  Academic Article
• Crystal structure of the lactose operon repressor and its complexes with DNA and inducer  Academic Article
• Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A  Academic Article
• Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of camp-dependent protein kinase  Academic Article
• Crystal structure of the spindle assembly checkpoint protein Bub3  Academic Article
• Crystal structure of the transcriptional repressor pagr of bacillus anthracis  Academic Article
• Crystal structure of the von Willebrand factor modulator botrocetin  Academic Article
• Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892  Academic Article
• Crystal structure of tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex  Academic Article
• Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases  Academic Article
• Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 Å resolution: Self-hydroxylation of phe300 and the pterin-binding site  Academic Article
• Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin  Academic Article
• Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34  Academic Article
• Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis  Academic Article
• Crystal structures of a quorum-quenching antibody  Academic Article
• Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP  Academic Article
• Crystal structures of apolipoprotein(a) kringle iv37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: Existence of novel and expected binding modes  Academic Article
• Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases  Academic Article
• Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR  Academic Article
• Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates  Academic Article
• Crystal structures of human topoisomerase i in covalent and noncovalent complexes with DNA  Academic Article
• Crystal structures of leukotriene a(4) hydrolase in complex with captopril and two competitive tight-binding inhibitors  Academic Article
• Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands  Academic Article
• Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors  Academic Article
• Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain  Academic Article
• Crystal structures of the free and liganded form of an esterolytic catalytic antibody  Academic Article
• Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor  Academic Article
• Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake  Academic Article
• Crystal structures of transhydrogenase domain i with and without bound nadh  Academic Article
• Crystal structures of two I-A(d)-peptide complexes reveal that high affinity can be achieved without large anchor residues  Academic Article
• Crystal structures of two rat mhc class ia (rt1-a) molecules that are associated differentially with peptide transporter alleles tap-a and tap-b  Academic Article
• Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains  Academic Article
• Crystal-structure and mutational analysis of human uracil-DNA glycosylase - structural basis for specificity and catalysis  Academic Article
• Crystal-structure of an h-2k(b)-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove  Academic Article
• Crystal-structure of cd,zn metallothionein  Academic Article
• Crystal-structure of human uracil-DNA glycosylase in complex with a protein inhibitor - protein mimicry of DNA  Academic Article
• Crystal-structure of murine cyclophilin-c complexed with immunosuppressive drug cyclosporine-a  Academic Article
• Crystal-structure of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f at 2.2 Å resolution  Academic Article
• Crystal-structure of the human cell-cycle protein ckshs1 - single-domain fold with similarity to kinase n-lobe domain  Academic Article
• Crystal-structures of 2 viral peptides in complex with murine mhc class-i h-2k(b)  Academic Article
• Crystal-structures of a schistosomal drug and vaccine target - glutathione-s-transferase from schistosoma-japonica and its complex with the leading antischistosomal drug praziquantel  Academic Article
• Crystal-structures of aconitase with isocitrate and nitroisocitrate bound  Academic Article
• Crystal-structures of aconitase with trans-aconitate and nitrocitrate bound  Academic Article
• Crystallization and preliminary x-ray crystallographic analysis of aart, a designed six-finger zinc-finger peptide, bound to DNA  Academic Article
• Crystallographic analysis of 2 site-directed mutants of azotobacter-vinelandii ferredoxin  Academic Article
• Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG  Academic Article
• Crystallographic fragment-based drug discovery: use of a brominated fragment library targeting HIV protease  Academic Article
• Cu,Zn superoxide dismutase structure from a microbial pathogen establishes a class with a conserved dimer interface  Academic Article
• Curariform antagonists bind in different orientations to acetylcholine-binding protein  Academic Article
• Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins  Academic Article
• Custom zinc-finger nucleases for use in human cells  Academic Article
• Cyclic and linear oligocarbamate ligands for human thrombin  Academic Article
• Cyclin-dependent kinases 5 template: useful for virtual screening  Academic Article
• Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation  Academic Article
• Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site  Academic Article
• Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites  Academic Article
• Cys-X scanning for expansion of active-site residues and modulation of catalytic functions in a glutathione transferase  Academic Article
• CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis  Academic Article
• Cysteine residues are not essential for the catalytic activity of human class Mu glutathione transferase M1a-1a  Academic Article
• Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import  Academic Article
• Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif  Academic Article
• D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain  Academic Article
• DNA apurinic-apyrimidinic site binding and excision by endonuclease iv  Academic Article
• DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex  Academic Article
• DNA binding and nucleotide flipping by the human DNA repair protein agt  Academic Article
• DNA loops induced by cooperative binding of transcriptional activator proteins and preinitiation complexes  Academic Article
• DNA protein complexes during attachment-site synapsis in Mu DNA transposition  Academic Article
• DNA recognition by a σ(54) transcriptional activator from Aquifex aeolicus  Academic Article
• DNA sequence-directed nucleosome reconstitution on 5S RNA genes of Xenopus-laevis  Academic Article
• DNA-binding proteins in human-serum  Academic Article
• DNA-induced alpha-helix capping in conserved linker sequences is a determinant of binding affinity in Cys(2)-His(2) zinc fingers  Academic Article
• DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes  Academic Article
• De novo computational design of retro-aldol enzymes  Academic Article
• Deep cavitands provide organized solvation of reactions  Academic Article
• Defining GC-specificity in the minor groove: Side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G  Academic Article
• Defining the communication between agonist and coactivator binding in the retinoid X receptor alpha ligand binding domain  Academic Article
• Definition of the binding-sites of individual zinc fingers in the transcription factor-IIIA-5S RNA gene-complex  Academic Article
• Delineation of spontaneous erythrocyte autoantibody responses of nzb and other strains of mice  Academic Article
• Delineation of the peptide binding site of the human galanin receptor  Academic Article
• Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: Noncovalent binding coincidental with alkylation  Academic Article
• Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit  Academic Article
• Demonstration of circulating immune complexes in Sjögren's syndrome  Academic Article
• Density functional and electrostatics study of oxidized and reduced ribonucleotide reductase: comparisons with methane monooxygenase  Academic Article
• Density functional calculation of pKa values and redox potentials in the bovine Rieske iron-sulfur protein  Academic Article
• Density functional studies of oxidized and reduced methane monooxygenase. Optimized geometries and exchange coupling of active site clusters  Academic Article
• Density functional theory study of Fe(IV) d-d optical transitions in active-site models of class I ribonucleotide reductase intermediate X with vertical self-consistent reaction field methods  Academic Article
• Derivation of a retinoid x receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1h-indol-3-yl)methyl-4-trifluoromethylbenzene  Academic Article
• Design and characterization of an active site selective caspase-3 transnitrosating agent  Academic Article
• Design and evolution of new catalytic activity with an existing protein scaffold  Academic Article
• Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives  Academic Article
• Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300  Academic Article
• Design and synthesis of c5 methylated l-arginine analogues as active site probes for nitric oxide synthase  Academic Article
• Design and synthesis of novel CCR2 antagonists: Investigation of non-aryl/heteroaryl binding motifs  Academic Article
• Design and synthesis of selenazole-containing peptides for cocrystallization with p-glycoprotein  Academic Article
• Design of a functional membrane protein by engineering a heme-binding site in glycophorin A  Academic Article
• Design of a redox-linked active metal site: manganese bound to bacterial reaction centers at a site resembling that of photosystem II  Academic Article
• Design of allele-specific protein methyltransferase inhibitors  Academic Article
• Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d  Academic Article
• Design of polydactyl zinc-finger proteins for unique addressing within complex genomes  Academic Article
• Design of potent and selective 2-aminobenzimidazole-based p38 alpha MAP kinase inhibitors with excellent in vivo efficacy  Academic Article
• Design of stapled DNA-minor-groove-binding molecules with a mutable atom simulated annealing method  Academic Article
• Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors  Academic Article
• Design, synthesis and evaluation of 2,5-diketopiperazines as inhibitors of the MDM2-p53 interaction  Academic Article
• Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors  Academic Article
• Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants  Academic Article
• Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators  Academic Article
• Designing small-molecule switches for protein-protein interactions  Academic Article
• Designing transcription factor architectures for drug discovery  Academic Article
• Detection of a catalytic antibody species acylated at the active site by electrospray mass spectrometry  Academic Article
• Detection of a ternary complex of nf-kappa b and i kappa b alpha with DNA provides insights into how i kappa b alpha removes nf-kappa b from transcription sites  Academic Article
• Detection of leucine-independent DNA site occupancy of the yeast Leu3p transcriptional activator in vivo  Academic Article
• Determinants of DNA mismatch recognition within the polymerase domain of the klenow fragment  Academic Article
• Determinants of cytochrome P4502C8 substrate binding - structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid  Academic Article
• Determination and analysis of the 2A structure of copper, zinc superoxide-dismutase  Academic Article
• Determination of matrix metalloproteinase activity using biotinylated gelatin  Academic Article
• Determination of the 3-dimensional structure of metallothioneins by nuclear-magnetic-resonance spectroscopy in solution  Academic Article
• Determination of the NMR solution structure of the cyclophilin-a - cyclosporine-a complex  Academic Article
• Determination of the coordination geometry at the heme iron in 3 cytochromes-c from saccharomyces-cerevisiae and from candida-krusei based on individual h-1-NMR assignments for heme-c and the axially coordinated amino-acids  Academic Article
• Determination of the nuclear-magnetic-resonance solution structure of the DNA-binding domain (residues 1 to 69) of the 434 repressor and comparison with the x-ray crystal-structure  Academic Article
• Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface  Academic Article
• Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair  Academic Article
• Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor  Academic Article
• Development of 5N-bicalutamide, a high-affinity reversible covalent antiandrogen  Academic Article
• Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors  Academic Article
• Development of Pseudomonas aeruginosa lectin LecA inhibitor by using bivalent galactosides supported on polyproline peptide scaffolds  Academic Article
• Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors  Academic Article
• Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties  Academic Article
• Development of new enzymatic catalysts for peptide-synthesis in aqueous and organic-solvents  Academic Article
• Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: Defining the binding mode of 7-oxabicyclo 2.2.1 hept-5-ene scaffold core ligands  Academic Article
• Development of sulfonamide photoaffinity inhibitors for probing cellular γ-secretase  Academic Article
• Development of thioquinazolinones, allosteric Chk1 kinase inhibitors  Academic Article
• Development of zinc finger domains for recognition of the 5 '-ann-3 ' family of DNA sequences and their use in the construction of artificial transcription factors  Academic Article
• Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies  Academic Article
• Developmentally regulated proteins of plasma-membrane of dictyostelium-discoideum - carbohydrate-binding protein  Academic Article
• Dextran as a generally applicable multivalent scaffold for improving immunoglobulin-binding affinities of peptide and peptidomimetic ligands  Academic Article
• Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes  Academic Article
• Differential and antagonistic effects of v-jun and c-jun  Academic Article
• Differential infection of receptor-modified host-cells by receptor-specific influenza-viruses  Academic Article
• Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis  Academic Article
• Difficulties in determining accurate molecular-motion parameters from proton relaxation enhancement measurements as illustrated by immunoglobulin-g . Gd(iii) system  Academic Article
• Dimerization of the klenow fragment of escherichia coli DNA polymerase i is linked to its mode of DNA binding  Academic Article
• Direct association between the yeast rad51 and rad54 recombination proteins  Academic Article
• Direct evidence for manganese(iii) binding to manganosuperoxide dismutase of escherichia-coli-b  Academic Article
• Direct measurement of the aspartic acid 26 pK(a) for reduced Escherichia coli thioredoxin by (13)C NMR  Academic Article
• Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance  Academic Article
• Direct regulation of clock expression by rev-erb  Academic Article
• Directed evolution of a bright near-infrared fluorescent rhodopsin using a synthetic chromophore  Academic Article
• Directed evolution of d-sialic acid aldolase to l-3-deoxy-manno-2-octulosonic acid (l-kdo) aldolase  Academic Article
• Directed evolution of the TALE N-terminal domain for recognition of all 5' bases  Academic Article
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• Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II)  Academic Article
• Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)  Academic Article
• Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors  Academic Article
• Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering  Academic Article
• Discovery of a small molecule insulin mimetic with antidiabetic activity in mice  Academic Article
• Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library  Academic Article
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• Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design  Academic Article
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• Discovery of potent and selective covalent inhibitors of JNK  Academic Article
• Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists  Academic Article
• Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor's potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations  Academic Article
• Discovery of protein phosphatase 2C inhibitors by virtual screening  Academic Article
• Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase i7l using homology modeling and covalent docking approaches  Academic Article
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• Discrimination between steady-state kinetic models of the mechanism of action of yeast glyoxalase I  Academic Article
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• Disorder-to-order transition of the active site of human class Pi glutathione transferase, GST P1-1  Academic Article
• Dispensable pieces of an aminoacyl tRNA synthetase which activate the catalytic site  Academic Article
• Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F  Academic Article
• Dissecting the neutralizing antibody-specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors  Academic Article
• Dissection of a class II tRNA synthetase: determinants for minihelix recognition are tightly associated with domain for amino acid activation  Academic Article
• Dissection of an antibody-catalyzed reaction  Academic Article
• Dissociation of clathrin coats coupled to the hydrolysis of atp - role of an uncoating atpase  Academic Article
• Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs  Academic Article
• Distamycin and penta-N-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving  Academic Article
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• Distinct domains of tRNA synthetase recognize the same base pair  Academic Article
• Distinct structural attributes regulating von Willebrand factor A1 domain interaction with platelet glycoprotein Ib alpha under flow  Academic Article
• Distinguishing binders from false positives by free energy calculations: fragment screening against the flap site of HIV protease  Academic Article
• Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes  Academic Article
• Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin  Academic Article
• Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors  Academic Article
• Diversified sequences of peptide epitope for same-RNA recognition  Academic Article
• Diving into the water: inducible binding conformations for BRD4, TAF1(2), BRD9, and CECR2 bromodomains  Academic Article
• Do active site conformations of small ligands correspond to low free-energy solution structures?  Academic Article
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• Docking of 4-oxalocrotonate tautomerase substrates: implications for the catalytic mechanism  Academic Article
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• Domain-domain communication in a miniature archaebacterial tRNA synthetase  Academic Article
• Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling. Mapping with receptor-derived peptides  Academic Article
• Double strand binding-single strand incision mechanism for human flap endonuclease: Implications for the superfamily  Academic Article
• Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc)  Academic Article
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• Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase  Academic Article
• Dual conformations for the hiv-1 gp120 v3 loop in complexes with different neutralizing fabs  Academic Article
• Dynamic structure of retinylidene ligand of rhodopsin probed by molecular simulations  Academic Article
• Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase  Academic Article
• Dynamic visualization of transcription and RNA subcellular localization in zebrafish  Academic Article
• Dynamics of lysozyme-saccharide interactions  Academic Article
• Dynamics of the dihydrofolate-reductase folate complex - catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features  Academic Article
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• EF5 is the high-affinity Mg2+ site in ALG-2  Academic Article
• Easybound - a user-friendly approach to nonlinear regression analysis of binding data  Academic Article
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• Effect of aminoacyl transfer RNA synthetases on H-5 exchange of specific pyrimidines in transfer RNAs  Academic Article
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• Effect of disulfide bridge formation on the NMR spectrum of a protein: studies on oxidized and reduced Escherichia coli thioredoxin  Academic Article
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• Effect of the peptide moiety of lipid ii on bacterial transglycosylase  Academic Article
• Effect of the ubiquitous transcription factors, SP1 and MAZ, on NMDA receptor subunit type 1 (NR1) expression during neuronal differentiation  Academic Article
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• Functional cavitands: Chemical reactivity in structured environments  Academic Article
• Functional cis-heterodimers of N- and R-cadherins  Academic Article
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• Functional dissection of a predicted class-defining motif in a class II tRNA synthetase of unknown structure  Academic Article
• Functional dissection of circadian clock- and phytochrome-regulated transcription of the Arabidopsis CAB2 gene  Academic Article
• Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3  Academic Article
• Functional interrogation of the kinome using nucleotide acyl phosphates  Academic Article
• Functional mimicry of a protein hormone by a peptide agonist: The epo receptor complex at 2.8 Å  Academic Article
• Functional modulation of the isolated glycoprotein Ib binding domain of von Willebrand factor expressed in Escherichia coli  Academic Article
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• Functional redundancy in the nonspecific RNA binding domain of a class I tRNA synthetase  Academic Article
• Functional role for a conserved aspartate in the spo0e signature motif involved in the dephosphorylation of the bacillus subtilis sporulation regulator spo0a  Academic Article
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• Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein e2c direct integration of viral DNA into specific sites  Academic Article
• GIGANTEA directly activates Flowering Locus T in Arabidopsis thaliana  Academic Article
• GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex  Academic Article
• GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function  Academic Article
• Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B  Academic Article
• Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors  Academic Article
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• Gene transcription through activation of G-protein-coupled chemoattractant receptors  Academic Article
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• Generation of a Ni(II) binding site by introduction of a histidine cluster in the structure of human glutathione transferase A1-1  Academic Article
• Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe  Academic Article
• Genetic introduction of a diketone-containing amino acid into proteins  Academic Article
• Genetic selection of short peptides that support protein oligomerization in vivo  Academic Article
• Genetically encoded fragment-based discovery of glycopeptide ligands for carbohydrate-binding proteins  Academic Article
• Genome-wide analysis of CREB target genes reveals a core promoter requirement for camp responsiveness  Academic Article
• Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues  Academic Article
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• Genome-wide identification of bcl11b gene targets reveals role in brain-derived neurotrophic factor signaling  Academic Article
• Genome-wide nucleosome mapping of plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes  Academic Article
• Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma  Academic Article
• Genomic effects of polyamide/DNA interactions on mRNA expression  Academic Article
• Genomic-scale comparison of sequence- and structure-based methods of function prediction: Does structure provide additional insight?  Academic Article
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• Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles  Academic Article
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• Glutathione transferases with novel active sites isolated by phage display from a library of random mutants  Academic Article
• Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2  Academic Article
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• Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin  Academic Article
• Gp120: Biologic aspects of structural features  Academic Article
• Gpcr agonist binding revealed by modeling and crystallography  Academic Article
• Growth hormone releasing substances: types and their receptors  Academic Article
• H-1 NMR-studies at 360 mhz of aromatic amino-acid residues in ferrocytochrome c-552 from euglena-gracilis  Academic Article
• H-1 NMR-studies at 360 mhz of methyl-groups in native and chemically modified basic pancreatic trypsin-inhibitor (bpti)  Academic Article
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• Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands  Academic Article
• Inhibition of a viral enzyme by a small-molecule dimer disruptor  Academic Article
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• Inhibition of glutathione reductase by interaction of 2, 4, 6-trinitrobenzenesulfonate with the active-site dithiol  Academic Article
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• Insights into PPAR gamma from structures with endogenous and covalently bound ligands  Academic Article
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• Involvement of an active-site Zn2+ ligand mechanism of human glyoxalase I  Academic Article
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• Isolated RNA binding domain of a class I tRNA synthetase  Academic Article
• Isolation and characterization of a collagen binding domain in human von Willebrand factor  Academic Article
• Isolation and characterization of maclura pomifera (mp) lectin  Academic Article
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• Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3 alpha 1  Academic Article
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• Selective binding-site for (prostacyclin-h-3 on platelets  Academic Article
• Selective chemical catalysis by an antibody  Academic Article
• Selective inhibition of ADAR2-catalyzed editing of the serotonin 2c receptor pre-mRNA by a helix-threading peptide  Academic Article
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• Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120  Academic Article
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• Structure and function of von Willebrand factor: relationship to von Willebrand's disease  Academic Article
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• Structure of a cation-bound multidrug and toxic compound extrusion transporter  Academic Article
• Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator  Academic Article
• Structure of a dicationic monoimidazole lexitropsin bound to DNA  Academic Article
• Structure of a kinesin microtubule depolymerization machine  Academic Article
• Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site  Academic Article
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• Structure of a protein photocycle intermediate by millisecond time-resolved crystallography  Academic Article
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• Structure of a v3-containing hiv-1 gp120 core  Academic Article
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• Structure of azotobacter vinelandii 7fe ferredoxin at 1.35 Å resolution and determination of the fe-s bonds with 0.01 Å accuracy  Academic Article
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• The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif  Academic Article
• The tau-4 activation domain of the thyroid-hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing  Academic Article
• The theoretical limits of DNA sequence discrimination by linked polyamides  Academic Article
• The thermotoga maritima trk potassium transporter-from frameshift to function  Academic Article
• The third Trp-Lys-Ser (WKS) tripeptide motif in tissue factor is associated with a function site  Academic Article
• The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli  Academic Article
• The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis  Academic Article
• The transcriptional control of the perforin locus  Academic Article
• The transition-state regulator hpr of bacillus-subtilis is a DNA-binding protein  Academic Article
• The transition-state transcription regulator abrb of bacillus-subtilis is a DNA-binding protein  Academic Article
• The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire  Academic Article
• The usher syndrome proteins cadherin 23 and harmonin form a complex by means of pdz-domain interactions  Academic Article
• The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin  Academic Article
• The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments  Academic Article
• The way things move: Looking under the hood of molecular motor proteins  Academic Article
• Thermodynamic analysis of purified human placental alpha-l-fucosidase  Academic Article
• Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase  Academic Article
• Thermodynamics of RNA-RNA duplexes with 2-or 4-thiouridines: implications for antisense design and targeting a group I intron  Academic Article
• Thiol ligation of two zinc atoms to a class I tRNA synthetase: evidence for unshared thiols and role in amino acid binding and utilization  Academic Article
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• Tissue factor - molecular recognition and cofactor function  Academic Article
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• Virtual screening against acetylcholine binding protein  Academic Article
• Virtual screening against alpha-cobratoxin  Academic Article
• Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors  Academic Article
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• X-ray absorption studies of the Zn2+ site of glyoxalase I  Academic Article
• X-ray absorption studies of the copper-beta domain of rat-liver metallothionein  Academic Article
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• X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus  Academic Article
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• X-ray structures of the LXRα LBD in its homodimeric form and implications for heterodimer signaling  Academic Article
• Xyloglucan sidechains modulate binding to cellulose during in vitro binding assays as predicted by conformational dynamics simulations  Academic Article
• Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway  Academic Article
• Yeast glyoxalase I is a monomeric enzyme with two active sites  Academic Article
• Yy1 binding to a subset of p53 DNA-target sites regulates p53-dependent transcription  Academic Article
• ZiF-Predict: a web tool for predicting DNA-binding specificity in C2H2 zinc finger proteins  Academic Article
• Zinc finger tools: Custom DNA-binding domains for transcription factors and nucleases  Academic Article
• Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology  Academic Article
• Zinc-dependent cell growth conferred by mutant tRNA synthetase  Academic Article
• Zinc-dependent tRNA binding by a peptide element within a tRNA synthetase  Academic Article
• Zinc-free and reduced t4 gene-32 protein binds single-stranded-DNA weakly and fails to stimulate uvsx-catalyzed homologous pairing  Academic Article
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• γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin  Academic Article