Binding Sites

subject area of

1.35 and 2.07 a resolution structures of the red abalone sperm lysin monomer and dimer reveal features involved in receptor binding Academic Article
10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase Academic Article
2,5-diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3) Academic Article
2-(3,5-dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor Academic Article
2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport Academic Article
3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting Academic Article
3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle Academic Article
3D domain swapping modulates the stability of members of an icosahedral virus group Academic Article
4-Aminoindazolyl-dihydrofuro 3,4-d pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase Academic Article
A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs Academic Article
A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis Academic Article
A base triple in the tetrahymena group i core affects the reaction equilibrium via a threshold effect Academic Article
A binding site for homeodomain and pax proteins is necessary for l1 cell adhesion molecule gene expression by pax-6 and bone morphogenetic proteins Academic Article
A binding site for pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord Academic Article
A branching reaction mechanism of glutathione reductase Academic Article
A brassinosteroid transcriptional network revealed by genome-wide identification of BESI target genes in Arabidopsis thaliana Academic Article
A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding Academic Article
A cell cycle phosphoproteome of the yeast centrosome Academic Article
A chemical, genetic, and structural analysis of the nuclear bile acid receptor fxr Academic Article
A chemically functionalized magnetic nanoplatform for rapid and specific biomolecular recognition and separation Academic Article
A chromatin binding-site in the tail domain of nuclear lamins that interacts with core histones Academic Article
A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease Academic Article
A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPAR gamma partial agonists Academic Article
A complex assembly landscape for the 30S ribosomal subunit Academic Article
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis Academic Article
A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles Academic Article
A conserved hiv gp120 glycoprotein structure involved in chemokine receptor binding Academic Article
A conserved motif in the itk ph-domain is required for phosphoinositide binding and tcr signaling but dispensable for adaptor protein interactions Academic Article
A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase Academic Article
A de novo designed peptide ligase: A mechanistic investigation Academic Article
A de novo protein binding pair by computational design and directed evolution Academic Article
A density functional evaluation of an Fe(III)-Fe(IV) model diiron cluster: comparisons with ribonucleotide reductase intermediate X Academic Article
A designed inhibitor of a CLC antiporter blocks function through a unique binding mode Academic Article
A designed synthetic analogue of 4-OT is specific for a non-natural substrate Academic Article
A detailed structural model of cytotactin - protein homologies, alternative rna splicing, and binding regions Academic Article
A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons Academic Article
A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120 Academic Article
A dynamic search process underlies microRNA targeting Academic Article
A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol) Academic Article
A flexible interface between DNA ligase and pcna supports conformational switching and efficient ligation of DNA Academic Article
A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking Academic Article
A four-helical super-secondary structure Academic Article
A fragment of human TrpRS as a potent antagonist of ocular angiogenesis Academic Article
A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia-coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases Academic Article
A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock Academic Article
A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding Academic Article
A g-protein alpha-subunit from asexual candida-albicans functions in the mating signal transduction pathway of saccharomyces-cerevisiae and is regulated by the a1-alpha-2 repressor Academic Article
A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain Academic Article
A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells Academic Article
A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans Academic Article
A genetically encoded diazirine photocrosslinker in Escherichia coli Academic Article
A genetically encoded fluorescent amino acid Academic Article
A global benchmark study using affinity-based biosensors Academic Article
A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728 Academic Article
A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B Academic Article
A hierarchy of RNA subdomains in assembly of the central domain of the 30 S ribosomal subunit Academic Article
A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs Academic Article
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV Academic Article
A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein Academic Article
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS Academic Article
A linear amino acid sequence involved in the interaction of t-PA with its endothelial cell receptor Academic Article
A method for defining binding sites involved in protein-protein interactions: analysis of the binding of plasminogen activator inhibitor 1 to the somatomedin domain of vitronectin Academic Article
A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase Academic Article
A mutation in the human cyclin-dependent kinase interacting protein, ckshs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly Academic Article
A new decoration for nitric oxide synthase - a zn(cys)4 site Academic Article
A new mechanism of allostery in a G protein-coupled receptor dimer Academic Article
A new model for binding of kinesin 13 to curved microtubule protofilaments Academic Article
A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic c-1027 biosynthesis Academic Article
A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A Academic Article
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase Academic Article
A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties Academic Article
A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma Academic Article
A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va Academic Article
A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1 Academic Article
A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex Academic Article
A novel role of the budding yeast separin esp1 in anaphase spindle elongation: Evidence that proper spindle association of esp1 is regulated by pds1 Academic Article
A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity Academic Article
A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site Academic Article
A permutational approach toward protein-DNA recognition Academic Article
A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis Academic Article
A poly(A) binding protein functions in the chloroplast as a message-specific translation factor Academic Article
A positive feedback loop controls transcription of the spoof gene, a component of the sporulation phosphorelay in bacillus-subtilis Academic Article
A protein-S binding-site on C4b-binding protein involves beta-chain residues 31-45 Academic Article
A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.Fem-3 mRNA complex Academic Article
A random walk in oncogene space: The quest for targets Academic Article
A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation Academic Article
A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin Academic Article
A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria Academic Article
A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: Crystal structure of spo0f from bacillus subtilis Academic Article
A retroviral-like metal binding motif in an aminoacyl-tRNA synthetase is important for tRNA recognition Academic Article
A reversible reaction inside a self-assembled capsule Academic Article
A ribozyme composed of only two different nucleotides Academic Article
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus Academic Article
A role for ranbp1 in the release of crm1 from the nuclear pore complex in a terminal step of nuclear export Academic Article
A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280 Academic Article
A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib Academic Article
A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis Academic Article
A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases Academic Article
A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta Academic Article
A semisynthetic glutathione peroxidase with high catalytic efficiency: Selenoglutathione transferase Academic Article
A shape-dependent hydrophobic effect for tetrazoles Academic Article
A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth Academic Article
A silencer element in the retinoblastoma tumor-suppressor gene Academic Article
A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity Academic Article
A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure Academic Article
A single gal4 dimer can maximally activate transcription under physiological conditions Academic Article
A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors Academic Article
A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases Academic Article
A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases Academic Article
A small molecule inhibitor selective for a variant atp-binding site of the chaperonin groel Academic Article
A source of response regulator autophosphatase activity: The critical role of a residue adjacent to the spo0f autophosphorylation active site Academic Article
A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor Academic Article
A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle Academic Article
A sphingosine 1-phosphate receptor 2 selective allosteric agonist Academic Article
A stapled p53 helix overcomes HDMX-mediated suppression of p53 Academic Article
A steady-state kinetic model of butyrylcholinesterase from horse plasma Academic Article
A steady-state-kinetic random mechanism for glutathione S-transferase A from rat liver. A model involving kinetically significant enzyme-product complexes in the forward reaction Academic Article
A structural model for the high-valent intermediate Q of methane monooxygenase from broken-symmetry density functional and electrostatics calculations Academic Article
A structural model for the prostate disease marker, human prostate-specific antigen Academic Article
A structural perspective of the sequence variability within botulinum neurotoxin subtypes a1-a4 Academic Article
A structure-activity study of nociceptin-(1-13)-peptide amide. Synthesis of analogues substituted in positions 0, 1, 3, 4 and 10 Academic Article
A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase Academic Article
A synthetic receptor for phosphocholine esters Academic Article
A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease Academic Article
A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen Academic Article
A translation-like cycle is a quality control checkpoint for maturing 40s ribosome subunits Academic Article
A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5 Academic Article
A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry Academic Article
A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin mac-1 (cd11b cd18) Academic Article
A universal entropy-driven mechanism for thioredoxin-target recognition Academic Article
A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities Academic Article
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair Academic Article
ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization Academic Article
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase Academic Article
Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: The 3 ' ends justify the means Academic Article
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: Formation of a pterin radical is required for enzyme activity Academic Article
Ablating adenovirus type 5 fiber-car binding and hi loop insertion of the sigyplp peptide generate an endothelial cell-selective adenovirus Academic Article
Absence of G(i) proteins in the Sf9 insect cell. Characterization of the uncoupled recombinant N-formyl peptide receptor Academic Article
Acceptor helix interactions in a class II tRNA synthetase: photoaffinity cross-linking of an RNA miniduplex substrate Academic Article
Acceptor substrate-based selective inhibition of galactosyltransferases Academic Article
Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gpl120 is sterically restricted on primary human immunodeficiency virus type 1 Academic Article
Accessibility of nuclear chromatin by DNA binding polyamides Academic Article
Acetylcholine recognition by a deep, biomimetic pocket Academic Article
Acidophilic adaptations in the structure of Acetobacter aceti N-5-carboxyaminoimidazole ribonucleotide mutase (PurE) Academic Article
Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements Academic Article
Activation of Hageman factor in solid and fluid phases. A critical role of kallikrein Academic Article
Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1 Academic Article
Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete c-terminal domain Academic Article
Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the a subunits Academic Article
Activation of the redox-regulated chaperone hsp33 by domain unfolding Academic Article
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation Academic Article
Active and alkylated human agt structures: A novel zinc site, inhibitor and extrahelical base binding Academic Article
Active and inhibited human catalase structures: Ligand and nadph binding and catalytic mechanism Academic Article
Active site binding modes of curcumin in HIV-1 protease and integrase Academic Article
Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense Academic Article
Active site modification of factor viia affects interactions of the protease domain with tissue factor Academic Article
Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein Academic Article
Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties Academic Article
Active site residues of cyclophilin A are crucial for its signaling activity via CD147 Academic Article
Active site structure of Rieske-type proteins: electron nuclear double resonance studies of isotopically labeled phthalate dioxygenase from Pseudomonas cepacia and Rieske protein from Rhodobacter capsulatus and molecular modeling studies of a Rieske center Academic Article
Active site structure of class I ribonucleotide reductase intermediate X: a density functional theory analysis of structure, energetics, and spectroscopy Academic Article
Active site-directed inhibition of rabbit cytochrome P-450 1 by amino-substituted steroids Academic Article
Active thymus derived suppressor lymphocytes in human cord blood Academic Article
Active, interactive, and inactive steroid-receptor mutants Academic Article
Active-site and oligosaccharide recognition residues of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f Academic Article
Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3 Academic Article
Activity-based protein profiling for the functional annotation of enzymes Academic Article
Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid) Academic Article
Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2 Academic Article
Adding L-3-(2-naphthyl)alanine to the genetic code of E. coli Academic Article
Addition of an alpha-hydroxy acid to the genetic code of bacteria Academic Article
Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope Academic Article
Adenosine: a partial agonist of the growth hormone secretagogue receptor Academic Article
Adhesive properties of the isolated amino-terminal domain of platelet glycoprotein Ib alpha in a flow field Academic Article
Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenge Academic Article
Advances in pain therapeutics Academic Article
Affinity labeling of creatine kinase by N-(2,3-epoxypropyl)-N-amidinoglycine Academic Article
Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling Academic Article
Agonist-bound structure of the human P2Y(12) receptor Academic Article
Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence Academic Article
Alanine scanning mutagenesis of an alpha beta T cell receptor: mapping the energy of antigen recognition Academic Article
Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA Academic Article
Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition Academic Article
Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase Academic Article
Aldehyde dehydrogenase inhibitors: A comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application Academic Article
Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors Academic Article
Allosteric inhibition of hypoxia inducible factor-2 with small molecules Academic Article
Allosteric inhibition via R-state destabilization in ATP sulfurylase from Penicillium chrysogenum Academic Article
Alternative outcomes in assembly of promoter complexes: The roles of TBP and a flexible linker in placing TFIIIB on tRNA genes Academic Article
Amino acid derived quinazolines as Rock/PKA inhibitors Academic Article
Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles Academic Article
Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib Academic Article
Amino acid substitution at the dimeric interface of human manganese superoxide dismutase Academic Article
Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase Academic Article
Aminoacylation of RNA minihelices: implications for tRNA synthetase structural design and evolution Academic Article
Aminoglycoside binding in the major groove of duplex rna: The thermodynamic and electrostatic forces that govern recognition Academic Article
Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase Academic Article
An AP-1 site is involved in the NGF induction of IL-1α in PC12 cells Academic Article
An L-RNA aptamer that binds and inhibits RNase Academic Article
An NMR perspective on enzyme dynamics Academic Article
An RNA binding site in a tRNA synthetase with a reduced set of amino acids Academic Article
An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors Academic Article
An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide Academic Article
An acyloxymethyl ketone-based probe to monitor the activity of glutathionylspermidine amidase in Escherichia coli Academic Article
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1 Academic Article
An alternate binding site for PPARγ ligands Academic Article
An alternative processing of integrin αv subunit in tumor cells by membrane type-1 matrix metalloproteinase Academic Article
An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance Academic Article
An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode Academic Article
An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription Academic Article
An analysis of a class of DNA sequence reading molecules Academic Article
An aptamer that neutralizes r5 strains of hiv-1 binds to core residues of gp120 in the ccr5 binding site Academic Article
An aptamer that neutralizes r5 strains of human immunodeficiency virus type 1 blocks gp120-ccr5 interaction Academic Article
An engineered mutant of hiv-1 gp120 formulated with adjuvant quil a promotes elicitation of antibody responses overlapping the cd4-binding site Academic Article
An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured Academic Article
An essential histidine residue in the catalytic mechanism of mammalian glutathione reductase Academic Article
An essential role for the conserved Glu-133 in the anion interaction with superoxide-dismutase Academic Article
An evolutionary approach to the design of glutathione-linked enzymes Academic Article
An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity Academic Article
An improved zinc-finger nuclease architecture for highly specific genome editing Academic Article
An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation Academic Article
An inhibitor of sequence-specific proteolysis that targets the substrate rather than the enzyme Academic Article
An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity Academic Article
An intramolecular signaling element that modulates dynamin function in vitro and in vivo Academic Article
An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin 5 Academic Article
An o-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses Academic Article
An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution Academic Article
An operational RNA code for amino acids and variations in critical nucleotide sequences in evolution Academic Article
An oxetane-based polyketide surrogate To probe substrate binding in a polyketide synthase Academic Article
An unusual dimeric structure and assembly for tlr4 regulator rp105-md-1 Academic Article
Analysis of bacteriophage N protein and peptide binding to boxB RNA using polyacrylamide gel coelectrophoresis (PACE) Academic Article
Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes Academic Article
Analysis of hapten binding and catalytic determinants in a family of catalytic antibodies Academic Article
Analysis of structure-function relationships in the platelet membrane glycoprotein Ib-binding domain of von Willebrand's factor by expression of deletion mutants Academic Article
Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo Academic Article
Analysis of the class i aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99 Å resolution Academic Article
Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity Academic Article
Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera Academic Article
Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: Insight into the chaotrope unfolding dichotomy Academic Article
Anisotropic molecular rotational diffusion in n-15 spin relaxation studies of protein mobility Academic Article
Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists Academic Article
Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres Academic Article
Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones Academic Article
Anti-diabetic drug binding site in a mammalian K-ATP channel revealed by Cryo-EM Academic Article
Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen Academic Article
Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides Academic Article
Antibodies raised against beta-adrenergic receptors stimulate adenylate-cyclase Academic Article
Antibody 2g12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the hiv-1 glycan shield if domain exchanged Academic Article
Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike Academic Article
Antibody binding defines a structure for an epitope that participates in the prpc -> prpsc conformational change Academic Article
Antibody catalysis of the oxidation of water Academic Article
Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics Academic Article
Antibody microarrays utilizing site-specific antibody-oligonucleotide conjugates Academic Article
Antibody neutralization epitopes and integrin binding sites on nonenveloped viruses Academic Article
Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env Academic Article
Antibody structure and molecular immunology Academic Article
Antibody structure, diversity, and specificity Academic Article
Antibody vs. HIV in a clash of evolutionary titans Academic Article
Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions Academic Article
Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation Academic Article
Anticodon G recognition by tRNA synthetases mimics the tRNA core Academic Article
Antifungal azoles: structural insights into undesired tight binding to cholesterol-metabolizing CYP46A1 Academic Article
Antigen recognition by variable lymphocyte receptors Academic Article
Antiidiotype and antihormone receptor antibodies Academic Article
Antimitotic agents of natural origin Academic Article
Ap-2/eps15 interaction is required for receptor-mediated endocytosis Academic Article
Apo raver1 structure reveals distinct RRM domain orientations Academic Article
Application of nuclear magnetic-resonance spectroscopy to proteins Academic Article
Approaches toward selective inhibition of nitric oxide synthase Academic Article
Aptly named aptamers display their aptitude Academic Article
Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation Academic Article
Archaeal flagellar atpase motor shows atp-dependent hexameric assembly and activity stimulation by specific lipid binding Academic Article
Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors Academic Article
Architecture of the mediator head module Academic Article
Arginine-54 in the active-site of escherichia-coli aspartate transcarbamoylase is critical for catalysis - a site-specific mutagenesis, NMR, and x-ray crystallographic study Academic Article
Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions Academic Article
Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor Academic Article
Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein Academic Article
Aspartate-transcarbamylase lacking catalytic subunit interactions - study of conformational-changes by uv absorbance and circular-dichroism spectroscopy Academic Article
Aspects of the molecular-structure of igg subclasses Academic Article
Assembly of hybrid bacteriophage Qβ virus-like particles Academic Article
Assembly of the ebola virus nucleoprotein from a chaperoned VP35 complex Academic Article
Assembly-directed antivirals differentially bind quasiequivalent pockets to modify hepatitis B virus capsid tertiary and quaternary structure Academic Article
Assessment of major and minor groove DNA interactions by the zinc fingers of xenopus transcription factor IIIA Academic Article
Association of Sindbis virus capsid protein with phospholipid membranes and the E2 glycoprotein: implications for alphavirus assembly Academic Article
Association of plasma apolipoproteins d with rbc membrane arachidonic acid levels in schizophrenia Academic Article
Association of the cytoplasmic domain of intercellular-adhesion molecule-1 with glyceraldehyde-3-phosphate dehydrogenase and beta-tubulin Academic Article
Asymmetric DNA binding by a homodimeric bHLH protein Academic Article
Asymmetric organic synthesis with catalytic antibodies Academic Article
Atomic and residue hydrophilicity in the context of folded protein structures Academic Article
Atomic coordinates and molecular-conformation of yeast phenylalanyl transfer-rna - independent investigation Academic Article
Atomic coordinates for triose phosphate isomerase from chicken muscle Academic Article
Atp induces conformational changes in the carboxyl-terminal region of clc-5 Academic Article
Attachment of ribosome crystals to intracellular membranes Academic Article
Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor Academic Article
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading Academic Article
AutoDock4(Zn): an improved AutoDock force field for small-molecule docking to zinc metalloproteins Academic Article
AutoDockFR: Advances in protein-ligand docking with explicitly specified binding site flexibility Academic Article
Autoactivation of avian urokinase-type plasminogen activator (upa) - a novel mode of initiation of the upa/plasmin cascade Academic Article
Automated docking in crystallography: analysis of the substrates of aconitase Academic Article
Automated docking of ligands to an artificial active site: augmenting crystallographic analysis with computer modeling Academic Article
Automated docking of substrates to proteins by simulated annealing Academic Article
Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase Academic Article
Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications Academic Article
Automated identification of functional dynamic contact networks from X-ray crystallography Academic Article
Automated prediction of ligand-binding sites in proteins Academic Article
Avian winged helix proteins CWH-1, CWH-2 and CWH-3 repress transcription from Qin binding sites Academic Article
Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential Academic Article
Azurin as a protein scaffold for a low-coordinate nonheme iron site with a small-molecule binding pocket Academic Article
B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention Academic Article
BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein Academic Article
BMix: probabilistic modeling of occurring substitutions in PAR-CLIP data Academic Article
BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint Academic Article
BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases Academic Article
Bacillus subtilis hydrolyzes chey-p at the location of its action, the flagellar switch Academic Article
Backbone dynamics in dihydrofolate reductase complexes: Role of loop flexibility in the catalytic mechanism Academic Article
Bacterial pleckstrin homology domains: A prokaryotic origin for the PH domain Academic Article
Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery Academic Article
Barx2 controls myoblast fusion and promotes MyoD-mediated activation of the smooth muscle alpha-actin gene Academic Article
Basal lamina strengthens cell membrane integrity via the laminin g domain-binding motif of alpha-dystroglycan Academic Article
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA Academic Article
Base pairing between hepatitis C virus RNA and 18S rRNA is required for IRES-dependent translation initiation in vivo Academic Article
Beads-on-a-string, characterization of Ets-1 sumoylated within its flexible N-terminal sequence Academic Article
Behavior of holo-forms and apo-forms of bovine superoxide-dismutase at low ph Academic Article
Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: Towards a pharmacophore model for the nucleotide-binding domain Academic Article
Benzoquinones as inhibitors of botulinum neurotoxin serotype A Academic Article
Beta(2)-adrenergic receptor down-regulation - evidence for a pathway that does not require endocytosis Academic Article
Beta-endorphin stimulates proliferation of small-cell lung-carcinoma cells in-vitro via nonopioid binding-sites Academic Article
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Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va Academic Article
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C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock Academic Article
C-o bond formation by polyketide synthases Academic Article
C-terminal residues 621-635 of protein S are essential for binding to factor Va Academic Article
C-terminal zinc-containing peptide required for RNA recognition by a class I tRNA synthetase Academic Article
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CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5 Academic Article
CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes Academic Article
CSI-FID: high throughput label-free detection of DNA binding molecules Academic Article
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Ca2+ binding protects against gelsolin amyloidosis Academic Article
Ca2+ binding to the first epidermal growth factor module of coagulation factor viia is important for cofactor interaction and proteolytic function Academic Article
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Calcium-binding sites of calmodulin and electron transfer by inducible nitric oxide synthase Academic Article
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Calmodulin stabilizes an amphiphilic alpha-helix within rc3/neurogranin and gap-43/neuromodulin only when ca2+ is absent Academic Article
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Cassette mutagenesis of a potential substrate recognition region of cytochrome P450 2C2 Academic Article
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Cd-113 nuclear magnetic-resonance studies of cadmium-substituted derivatives of bovine superoxide-dismutase Academic Article
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Cell cycle phosphorylation of mitotic exit network (MEN) proteins Academic Article
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Characterization of the Runx gene family in a jawless vertebrate, the Japanese lamprey (Lethenteron japonicum) Academic Article
Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands Academic Article
Characterization of the core mammalian clock component, NPAS2, as a REV-ERB alpha/ROR alpha target gene Academic Article
Characterization of the electrophile binding site and substrate binding mode of the 26-kda glutathione s-transferase from schistosoma japonicum Academic Article
Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts Academic Article
Characterization of the initial alpha-thrombin interaction with glycoprotein Ib alpha in relation to platelet activation Academic Article
Characterization of the interaction of lassa fever virus with its cellular receptor alpha-dystroglycan Academic Article
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Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1 Academic Article
Characterization of the nuom (nd4) subunit in escherichia coli ndh-1 - conserved charged residues essential for energy-coupled activities Academic Article
Characterization of the promoter region and flanking sequences of the neuron-specific gene rc3 (neurogranin) Academic Article
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Characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy Academic Article
Charting a path to success in virtual screening Academic Article
Chemical approaches to nuclear receptors in metabolism Academic Article
Chemical characterization of ligand-binding site fragments from turkey beta-adrenergic-receptor Academic Article
Chemical expansion of cofactor activity Academic Article
Chemical markers of transplantation individuality solubilized with sonic energy Academic Article
Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferases Academic Article
Chemical shift as a probe of molecular interfaces: Nmr studies of DNA binding by the three amino-terminal zinc finger domains from transcription factor iiia Academic Article
Chemically programmed antibodies Academic Article
Chemically regulated zinc finger transcription factors Academic Article
Chemistry and molecular biology of galanin receptor ligands Academic Article
Chemistry for the analysis of protein-protein interactions: Rapid and efficient cross-linking triggered by long wavelength light Academic Article
Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environment Academic Article
Chemotype-selective modes of action of κ-opioid receptor agonists Academic Article
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Cholesterol seco-sterol-induced aggregation of methylated amyloid-β peptides - insights into aldehyde-initiated fibrillization of amyloid-β Academic Article
Chromaffin cell plasminogen receptors Academic Article
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Chromosomal integration dependent induction of junb by growth factors requires multiple flanking evolutionarily conserved sequences Academic Article
Circadian clock- and phytochrome-regulated transcription is conferred by a 78 bp cis-acting domain of the Arabidopsis CAB2 promoter Academic Article
Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP Academic Article
Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase Academic Article
Cis-preferential recruitment of duck hepatitis B virus core protein to the RNA/polymerase preassembly complex Academic Article
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Citrullination regulates pluripotency and histone H1 binding to chromatin Academic Article
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Click chemistry in situ: Acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks Academic Article
Cloning of cdnas for m-phase phosphoproteins recognized by the mpm2 monoclonal-antibody and determination of the phosphorylated epitope Academic Article
Cloning of the murine platelet glycoprotein Ib alpha gene highlighting species-specific platelet adhesion Academic Article
Closing the gate to the active site: Effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase Academic Article
Co-evolving motions at protein-protein interfaces of two-component signaling systems identified by covariance analysis Academic Article
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Coactivators PGC-1 beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen Academic Article
Cofactor residues lysine-165 and lysine-166 are critical for protein substrate recognition by the tissue factor-factor-viia protease complex Academic Article
Cohesin-mediated chromatin interactions-into the third dimension of gene regulation Academic Article
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Comparison of isotope labeling patterns of purines in three specific transfer RNAs Academic Article
Comparison of the NMR solution structure and the x-ray crystal-structure of rat metallothionein-2 Academic Article
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Conformational polymorphism of cyclosporine-a Academic Article
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Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c Academic Article
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Contribution of five amino acid residues in the glutathione-binding site to the function of human glutathione transferase P1-1 Academic Article
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Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 Å resolution Academic Article
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Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution Academic Article
Crystal structure of Pasteurella haemolytica ferric ion-binding protein a reveals a novel class of bacterial iron-binding proteins Academic Article
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Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design Academic Article
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Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue Academic Article
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Crystal structure of human toll-like receptor 3 (tlr3) ectodomain Academic Article
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Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran Academic Article
Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding Academic Article
Crystal structure of the broadly cross-reactive hiv-1-neutralizing fab x5 and fine mapping of its epitope Academic Article
Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin a Academic Article
Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a k(+) channel inhibitor-like fold Academic Article
Crystal structure of the human 4-1BB/4-1BBL complex Academic Article
Crystal structure of the human TRPV2 channel ankyrin repeat domain Academic Article
Crystal structure of the lactose operon repressor and its complexes with DNA and inducer Academic Article
Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A Academic Article
Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of camp-dependent protein kinase Academic Article
Crystal structure of the spindle assembly checkpoint protein Bub3 Academic Article
Crystal structure of the transcriptional repressor pagr of bacillus anthracis Academic Article
Crystal structure of the von Willebrand factor modulator botrocetin Academic Article
Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892 Academic Article
Crystal structure of tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex Academic Article
Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases Academic Article
Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 Å resolution: Self-hydroxylation of phe300 and the pterin-binding site Academic Article
Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin Academic Article
Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34 Academic Article
Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis Academic Article
Crystal structures of a quorum-quenching antibody Academic Article
Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP Academic Article
Crystal structures of apolipoprotein(a) kringle iv37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: Existence of novel and expected binding modes Academic Article
Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases Academic Article
Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR Academic Article
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates Academic Article
Crystal structures of human topoisomerase i in covalent and noncovalent complexes with DNA Academic Article
Crystal structures of leukotriene a(4) hydrolase in complex with captopril and two competitive tight-binding inhibitors Academic Article
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands Academic Article
Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors Academic Article
Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain Academic Article
Crystal structures of the free and liganded form of an esterolytic catalytic antibody Academic Article
Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor Academic Article
Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake Academic Article
Crystal structures of transhydrogenase domain i with and without bound nadh Academic Article
Crystal structures of two I-A(d)-peptide complexes reveal that high affinity can be achieved without large anchor residues Academic Article
Crystal structures of two rat mhc class ia (rt1-a) molecules that are associated differentially with peptide transporter alleles tap-a and tap-b Academic Article
Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains Academic Article
Crystal-structure and mutational analysis of human uracil-DNA glycosylase - structural basis for specificity and catalysis Academic Article
Crystal-structure of an h-2k(b)-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove Academic Article
Crystal-structure of cd,zn metallothionein Academic Article
Crystal-structure of human uracil-DNA glycosylase in complex with a protein inhibitor - protein mimicry of DNA Academic Article
Crystal-structure of murine cyclophilin-c complexed with immunosuppressive drug cyclosporine-a Academic Article
Crystal-structure of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f at 2.2 Å resolution Academic Article
Crystal-structure of the human cell-cycle protein ckshs1 - single-domain fold with similarity to kinase n-lobe domain Academic Article
Crystal-structures of 2 viral peptides in complex with murine mhc class-i h-2k(b) Academic Article
Crystal-structures of a schistosomal drug and vaccine target - glutathione-s-transferase from schistosoma-japonica and its complex with the leading antischistosomal drug praziquantel Academic Article
Crystal-structures of aconitase with isocitrate and nitroisocitrate bound Academic Article
Crystal-structures of aconitase with trans-aconitate and nitrocitrate bound Academic Article
Crystallization and preliminary x-ray crystallographic analysis of aart, a designed six-finger zinc-finger peptide, bound to DNA Academic Article
Crystallographic analysis of 2 site-directed mutants of azotobacter-vinelandii ferredoxin Academic Article
Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG Academic Article
Crystallographic fragment-based drug discovery: use of a brominated fragment library targeting HIV protease Academic Article
Cu,Zn superoxide dismutase structure from a microbial pathogen establishes a class with a conserved dimer interface Academic Article
Curariform antagonists bind in different orientations to acetylcholine-binding protein Academic Article
Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins Academic Article
Custom zinc-finger nucleases for use in human cells Academic Article
Cyclic and linear oligocarbamate ligands for human thrombin Academic Article
Cyclin-dependent kinases 5 template: useful for virtual screening Academic Article
Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation Academic Article
Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site Academic Article
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites Academic Article
Cys-X scanning for expansion of active-site residues and modulation of catalytic functions in a glutathione transferase Academic Article
CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis Academic Article
Cysteine residues are not essential for the catalytic activity of human class Mu glutathione transferase M1a-1a Academic Article
Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import Academic Article
Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif Academic Article
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain Academic Article
DNA apurinic-apyrimidinic site binding and excision by endonuclease iv Academic Article
DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex Academic Article
DNA binding and nucleotide flipping by the human DNA repair protein agt Academic Article
DNA loops induced by cooperative binding of transcriptional activator proteins and preinitiation complexes Academic Article
DNA protein complexes during attachment-site synapsis in Mu DNA transposition Academic Article
DNA recognition by a σ(54) transcriptional activator from Aquifex aeolicus Academic Article
DNA sequence-directed nucleosome reconstitution on 5S RNA genes of Xenopus-laevis Academic Article
DNA-binding proteins in human-serum Academic Article
DNA-induced alpha-helix capping in conserved linker sequences is a determinant of binding affinity in Cys(2)-His(2) zinc fingers Academic Article
DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes Academic Article
De novo computational design of retro-aldol enzymes Academic Article
Deep cavitands provide organized solvation of reactions Academic Article
Defining GC-specificity in the minor groove: Side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G Academic Article
Defining the communication between agonist and coactivator binding in the retinoid X receptor alpha ligand binding domain Academic Article
Definition of the binding-sites of individual zinc fingers in the transcription factor-IIIA-5S RNA gene-complex Academic Article
Delineation of spontaneous erythrocyte autoantibody responses of nzb and other strains of mice Academic Article
Delineation of the peptide binding site of the human galanin receptor Academic Article
Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: Noncovalent binding coincidental with alkylation Academic Article
Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit Academic Article
Demonstration of circulating immune complexes in Sjögren's syndrome Academic Article
Density functional and electrostatics study of oxidized and reduced ribonucleotide reductase: comparisons with methane monooxygenase Academic Article
Density functional calculation of pKa values and redox potentials in the bovine Rieske iron-sulfur protein Academic Article
Density functional studies of oxidized and reduced methane monooxygenase. Optimized geometries and exchange coupling of active site clusters Academic Article
Density functional theory study of Fe(IV) d-d optical transitions in active-site models of class I ribonucleotide reductase intermediate X with vertical self-consistent reaction field methods Academic Article
Derivation of a retinoid x receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1h-indol-3-yl)methyl-4-trifluoromethylbenzene Academic Article
Design and characterization of an active site selective caspase-3 transnitrosating agent Academic Article
Design and evolution of new catalytic activity with an existing protein scaffold Academic Article
Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives Academic Article
Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300 Academic Article
Design and synthesis of c5 methylated l-arginine analogues as active site probes for nitric oxide synthase Academic Article
Design and synthesis of novel CCR2 antagonists: Investigation of non-aryl/heteroaryl binding motifs Academic Article
Design and synthesis of selenazole-containing peptides for cocrystallization with p-glycoprotein Academic Article
Design of a functional membrane protein by engineering a heme-binding site in glycophorin A Academic Article
Design of a redox-linked active metal site: manganese bound to bacterial reaction centers at a site resembling that of photosystem II Academic Article
Design of allele-specific protein methyltransferase inhibitors Academic Article
Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d Academic Article
Design of polydactyl zinc-finger proteins for unique addressing within complex genomes Academic Article
Design of potent and selective 2-aminobenzimidazole-based p38 alpha MAP kinase inhibitors with excellent in vivo efficacy Academic Article
Design of stapled DNA-minor-groove-binding molecules with a mutable atom simulated annealing method Academic Article
Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors Academic Article
Design, synthesis and evaluation of 2,5-diketopiperazines as inhibitors of the MDM2-p53 interaction Academic Article
Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors Academic Article
Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants Academic Article
Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators Academic Article
Designing small-molecule switches for protein-protein interactions Academic Article
Designing transcription factor architectures for drug discovery Academic Article
Detection of a catalytic antibody species acylated at the active site by electrospray mass spectrometry Academic Article
Detection of a ternary complex of nf-kappa b and i kappa b alpha with DNA provides insights into how i kappa b alpha removes nf-kappa b from transcription sites Academic Article
Detection of leucine-independent DNA site occupancy of the yeast Leu3p transcriptional activator in vivo Academic Article
Determinants of DNA mismatch recognition within the polymerase domain of the klenow fragment Academic Article
Determinants of cytochrome P4502C8 substrate binding - structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid Academic Article
Determination and analysis of the 2A structure of copper, zinc superoxide-dismutase Academic Article
Determination of matrix metalloproteinase activity using biotinylated gelatin Academic Article
Determination of the 3-dimensional structure of metallothioneins by nuclear-magnetic-resonance spectroscopy in solution Academic Article
Determination of the NMR solution structure of the cyclophilin-a - cyclosporine-a complex Academic Article
Determination of the coordination geometry at the heme iron in 3 cytochromes-c from saccharomyces-cerevisiae and from candida-krusei based on individual h-1-NMR assignments for heme-c and the axially coordinated amino-acids Academic Article
Determination of the nuclear-magnetic-resonance solution structure of the DNA-binding domain (residues 1 to 69) of the 434 repressor and comparison with the x-ray crystal-structure Academic Article
Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface Academic Article
Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair Academic Article
Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor Academic Article
Development of 5N-bicalutamide, a high-affinity reversible covalent antiandrogen Academic Article
Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors Academic Article
Development of Pseudomonas aeruginosa lectin LecA inhibitor by using bivalent galactosides supported on polyproline peptide scaffolds Academic Article
Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors Academic Article
Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties Academic Article
Development of new enzymatic catalysts for peptide-synthesis in aqueous and organic-solvents Academic Article
Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: Defining the binding mode of 7-oxabicyclo 2.2.1 hept-5-ene scaffold core ligands Academic Article
Development of sulfonamide photoaffinity inhibitors for probing cellular γ-secretase Academic Article
Development of thioquinazolinones, allosteric Chk1 kinase inhibitors Academic Article
Development of zinc finger domains for recognition of the 5 '-ann-3 ' family of DNA sequences and their use in the construction of artificial transcription factors Academic Article
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies Academic Article
Developmentally regulated proteins of plasma-membrane of dictyostelium-discoideum - carbohydrate-binding protein Academic Article
Dextran as a generally applicable multivalent scaffold for improving immunoglobulin-binding affinities of peptide and peptidomimetic ligands Academic Article
Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes Academic Article
Differential and antagonistic effects of v-jun and c-jun Academic Article
Differential infection of receptor-modified host-cells by receptor-specific influenza-viruses Academic Article
Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis Academic Article
Difficulties in determining accurate molecular-motion parameters from proton relaxation enhancement measurements as illustrated by immunoglobulin-g . Gd(iii) system Academic Article
Dimerization of the klenow fragment of escherichia coli DNA polymerase i is linked to its mode of DNA binding Academic Article
Direct association between the yeast rad51 and rad54 recombination proteins Academic Article
Direct evidence for manganese(iii) binding to manganosuperoxide dismutase of escherichia-coli-b Academic Article
Direct measurement of the aspartic acid 26 pK(a) for reduced Escherichia coli thioredoxin by (13)C NMR Academic Article
Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance Academic Article
Direct regulation of clock expression by rev-erb Academic Article
Directed evolution of a bright near-infrared fluorescent rhodopsin using a synthetic chromophore Academic Article
Directed evolution of d-sialic acid aldolase to l-3-deoxy-manno-2-octulosonic acid (l-kdo) aldolase Academic Article
Directed evolution of the TALE N-terminal domain for recognition of all 5' bases Academic Article
Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model Academic Article
Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II) Academic Article
Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I) Academic Article
Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors Academic Article
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering Academic Article
Discovery of a small molecule insulin mimetic with antidiabetic activity in mice Academic Article
Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library Academic Article
Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors Academic Article
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design Academic Article
Discovery of potent and bioavailable GSK-3β inhibitors Academic Article
Discovery of potent and selective covalent inhibitors of JNK Academic Article
Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists Academic Article
Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor's potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations Academic Article
Discovery of protein phosphatase 2C inhibitors by virtual screening Academic Article
Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase i7l using homology modeling and covalent docking approaches Academic Article
Discrete determinants in transfer RNA for editing and aminoacylation Academic Article
Discriminated selection among viral peptides with the appropriate anchor residues - implications for the size of the cytotoxic t-lymphocyte repertoire and control of viral-infection Academic Article
Discrimination between steady-state kinetic models of the mechanism of action of yeast glyoxalase I Academic Article
Dismissal of RNA polymerase II underlies a large ligand-induced enhancer decommissioning program Academic Article
Disorder-to-order transition of the active site of human class Pi glutathione transferase, GST P1-1 Academic Article
Dispensable pieces of an aminoacyl tRNA synthetase which activate the catalytic site Academic Article
Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F Academic Article
Dissecting the neutralizing antibody-specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors Academic Article
Dissection of a class II tRNA synthetase: determinants for minihelix recognition are tightly associated with domain for amino acid activation Academic Article
Dissection of an antibody-catalyzed reaction Academic Article
Dissociation of clathrin coats coupled to the hydrolysis of atp - role of an uncoating atpase Academic Article
Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs Academic Article
Distamycin and penta-N-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving Academic Article
Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments Academic Article
Distinct domains of tRNA synthetase recognize the same base pair Academic Article
Distinct structural attributes regulating von Willebrand factor A1 domain interaction with platelet glycoprotein Ib alpha under flow Academic Article
Distinguishing binders from false positives by free energy calculations: fragment screening against the flap site of HIV protease Academic Article
Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes Academic Article
Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin Academic Article
Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors Academic Article
Diversified sequences of peptide epitope for same-RNA recognition Academic Article
Diving into the water: inducible binding conformations for BRD4, TAF1(2), BRD9, and CECR2 bromodomains Academic Article
Do active site conformations of small ligands correspond to low free-energy solution structures? Academic Article
Docking molecules by families to increase the diversity of hits in database screens: Computational strategy and experimental evaluation Academic Article
Docking of 4-oxalocrotonate tautomerase substrates: implications for the catalytic mechanism Academic Article
Does this have a familiar ring? Academic Article
Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3 Academic Article
Domain swapping in inducible nitric-oxide synthase - electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer Academic Article
Domain-domain communication in a miniature archaebacterial tRNA synthetase Academic Article
Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling. Mapping with receptor-derived peptides Academic Article
Double strand binding-single strand incision mechanism for human flap endonuclease: Implications for the superfamily Academic Article
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc) Academic Article
Drug-induced autoimmune disease Academic Article
Druggable protein interaction sites are more predisposed to surface pocket formation than the rest of the protein surface Academic Article
Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase Academic Article
Dual conformations for the hiv-1 gp120 v3 loop in complexes with different neutralizing fabs Academic Article
Dynamic structure of retinylidene ligand of rhodopsin probed by molecular simulations Academic Article
Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase Academic Article
Dynamic visualization of transcription and RNA subcellular localization in zebrafish Academic Article
Dynamics of lysozyme-saccharide interactions Academic Article
Dynamics of the dihydrofolate-reductase folate complex - catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features Academic Article
Dynamin and its partners: A progress report Academic Article
Dynamin gtpase domain mutants that differentially affect gtp binding, gtp hydrolysis, and clathrin-mediated endocytosis Academic Article
Dynamin is membrane-active: Lipid insertion is induced by phosphoinositides and phosphatidic acid Academic Article
E2f-1 induces the stabilization of p53 but blocks p53-mediated transactivation Academic Article
EF5 is the high-affinity Mg2+ site in ALG-2 Academic Article
Easybound - a user-friendly approach to nonlinear regression analysis of binding data Academic Article
Editing by a tRNA synthetase: DNA aptamer-induced translocation and hydrolysis of a misactivated amino acid Academic Article
Effect of aminoacyl transfer RNA synthetases on H-5 exchange of specific pyrimidines in transfer RNAs Academic Article
Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase Academic Article
Effect of disulfide bridge formation on the NMR spectrum of a protein: studies on oxidized and reduced Escherichia coli thioredoxin Academic Article
Effect of polyanion-resistance on HIV-1 infection Academic Article
Effect of the peptide moiety of lipid ii on bacterial transglycosylase Academic Article
Effect of the ubiquitous transcription factors, SP1 and MAZ, on NMDA receptor subunit type 1 (NR1) expression during neuronal differentiation Academic Article
Effects of abnormal base ionizations on Mg(++) binding to transfer ribonucleic acid as studied by a fluorescent probe Academic Article
Effects of internal cleavages and mutations in the C-terminal region of NIa protease of turnip mosaic potyvirus on the catalytic activity Academic Article
Effects of mutations on the partitioning of DNA substrates between the polymerase and 3 '-5 ' exonuclease sites of DNA polymerase i (klenow fragment) Academic Article
Effects of transition metals on nitric oxide synthase catalysis Academic Article
Efficient incorporation of unnatural amino acids into proteins in Escherichia coli Academic Article
Electron and proton transfer in the ba(3) oxidase from thermus thermophilus Academic Article
Electron microscopy of an alpha-dystroglycan fragment containing receptor sites for lymphocytic choriomeningitis virus and laminin, and use of the receptoid body as a reagent to neutralize virus Academic Article
Electron paramagnetic resonance study of the active site of copper-substituted human glyoxalase I Academic Article
Electron tunneling in single crystals of Pseudomonas aeruginosa azurins Academic Article
Electron-microscopic analysis of modulation of lymphocyte receptor mobility Academic Article
Electrospray ionization mass-spectrometry as a mechanistic tool - mass of human-leukocyte elastase and a beta-lactam-derived e-i complex Academic Article
Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c Academic Article
Electrostatic recognition between superoxide and copper, zinc superoxide-dismutase Academic Article
Elucidation of the interleukin-15 binding site on its alpha receptor by NMR Academic Article
Emergence of novel enzyme quasi-species depends on the substrate matrix Academic Article
Emerging principles for the recognition of peptide antigens by mhc class-i molecules Academic Article
Empirical entropic contributions in computational docking: evaluation in APS reductase complexes Academic Article
Encapsidated atom-transfer radical polymerization in Qbeta virus-like nanoparticles Academic Article
Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme Academic Article
Energetic contributions and topographical organization of ligand-binding residues of tissue factor Academic Article
Energetics and affinity of the histone octamer for defined DNA sequences Academic Article
Energetics of hydrogen bond networks in rna: Hydrogen bonds surrounding g+1 and u42 are the major determinants for the tertiary structure stability of the hairpin ribozyme Academic Article
Energetics of oxidized and reduced methane monooxygenase active site clusters in the protein environment Academic Article
Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair Academic Article
Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection Academic Article
Engineering a periplasmic binding protein for amino acid sensors with improved binding properties Academic Article
Engineering of a metal coordinating site into human glutathione transferase M1-1 based on immobilized metal ion affinity chromatography of homologous rat enzymes Academic Article
Engineering of substrate selectivity for tissue factor.Factor viia complex signaling through protease-activated receptor 2 Academic Article
Engineering polydactyl zinc-finger transcription factors Academic Article
Engineering the enantioselectivity of glutathione transferase by combined active-site mutations and chemical modifications Academic Article
Engineering the melanocortin-4 receptor to control G(s) signaling in vivo Academic Article
Enhanced binding of rnap ii ctd phosphatase fcp1 to rap74 following ck2 phosphorylation Academic Article
Enhanced morphine analgesia in mice lacking beta-arrestin 2 Academic Article
Enhancement of the catalytic properties of human carbonic anhydrase-iii by site-directed mutagenesis Academic Article
Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway Academic Article
Enrichment of regulatory signals in conserved non-coding genomic sequence Academic Article
Enterotoxin residues determining t-cell receptor v-beta binding-specificity Academic Article
Enzymatic and chemical approaches for the synthesis of sialyl glycoconjugates Academic Article
Enzyme structure with two catalytic sites for double-sieve selection of substrate Academic Article
Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain Academic Article
Epr studies of the possible binding sites of the cluster n2, semiquinones, and specific inhibitors of the nadh : Quinone oxidoreductase (complex i) Academic Article
Equilibrium measurements of cognate and noncognate interactions between aminoacyl transfer RNA synthetases and transfer RNA Academic Article
Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability Academic Article
Errors from selective disruption of the editing center in a tRNA synthetase Academic Article
Escherichia coli leader peptidase: production of an active form lacking a requirement for detergent and development of peptide substrates Academic Article
Escherichia coli ribosomes bind to non-initiator sites of Qβ RNA in the absence of formylmethionyl transfer RNA Academic Article
Escherichia coli signal peptide peptidase A is a serine-lysine protease with a lysine recruited to the nonconserved amino-terminal domain in the S49 protease family Academic Article
Escherichia-coli aspartate carbamoyltransferase - the probing of crystal-structure analysis via site-specific mutagenesis Academic Article
Essential arginine residues in the pyridine nucleotide binding sites of glutathione reductase Academic Article
Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms Academic Article
Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants Academic Article
Evaluating the potential for halogen bonding in the oxyanion hole of ketosteroid isomerase using unnatural amino acid mutagenesis Academic Article
Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies Academic Article
Evaluation of c3 receptors on lymphoid cells with different complement sources Academic Article
Evaluation of functional analogs of CC-1065 and the duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e (C2BI) alkylation subunit Academic Article
Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor Academic Article
Evidence for a coordination position available to solute molecules on one of metals at active-center of reduced bovine superoxide-dismutase Academic Article
Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli Academic Article
Evidence for an inhibitory effect of the peptide galanin on dopamine release from the rat median eminence Academic Article
Evidence for breaking domain-domain functional communication in a synthetase-tRNA complex Academic Article
Evidence for dispensable sequences inserted into a nucleotide fold Academic Article
Evidence for distinct locations for metal binding sites in two closely related class I tRNA synthetases Academic Article
Evidence for redox regulation of the transcription factor NtcA, acting both as an activator and a repressor, in the cyanobacterium Anabaena PCC 7120 Academic Article
Evidence for specific n-terminal galanin fragment binding-sites in the rat-brain Academic Article
Evidence for the binding of ng-cam to laminin Academic Article
Evidence from cassette mutagenesis for a structure-function motif in a protein of unknown structure Academic Article
Evidence that specificity of microhelix charging by a class I tRNA synthetase occurs in the transition state of catalysis Academic Article
Evidence that the 3' end of a tRNA binds to a site in the adenylate synthesis domain of an aminoacyl-tRNA synthetase Academic Article
Evolution and mechanism from structures of an adp-ribosylating toxin and nad complex Academic Article
Evolution of aldolase antibodies in vitro: Correlation of catalytic activity and reaction-based selection Academic Article
Evolution of class-specific peptides targeting a hot spot of the Galphas subunit Academic Article
Evolution of glutathione transferases and related enzymes for the protection of cells against electrophiles Academic Article
Evolution of iron(II)-finger peptides by using a bipyridyl amino acid Academic Article
Evolutionary analysis of HIV-1 protease inhibitors: methods for design of inhibitors that evade resistance Academic Article
Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein Academic Article
Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme Academic Article
Examination of the transcription factor NtcA-binding motif by in vitro selection of DNA sequences from a random library Academic Article
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase Academic Article
Exon 5 encoded domain is not required for the toxic function of mutant sod1 but essential for the dismutase activity: Identification and characterization of two new sod1 mutations associated with familial amyotrophic lateral sclerosis Academic Article
Exosite interactions determine the affinity of factor x for the extrinsic xase complex Academic Article
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors Academic Article
Exploring the role of the solvent in the denaturation of a protein - a molecular-dynamics study of the DNA-binding domain of the 434-repressor Academic Article
Expression and characterization of the flavoprotein subcomplex composed of 50-kda (nqo1) and 25-kda (nqo2) subunits of the proton-translocating nadh-quinone oxidoreductase of paracoccus denitrificans Academic Article
Extensive amino-acid-sequence homologies between animal lectins Academic Article
Extent of protein-protein interactions and quasi-equivalence in viral capsids Academic Article
External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification Academic Article
Extraordinarily slow binding of guanosine to the Tetrahymena group I ribozyme: Implications for RNA preorganization and function Academic Article
F-box protein grr1 interacts with phosphorylated targets via the cationic surface of its leucine-rich repeat Academic Article
Fabrication of an oriented Fc-fused lectin microarray through boronate formation. Academic Article
Factor Va residues 311-325 represent an activated protein C binding region Academic Article
Factor XI interacts with the leucine-rich repeats of glycoprotein Ib alpha on the activated platelet Academic Article
Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling Academic Article
Fast product formation and slow product release are important features in a hysteretic reaction mechanism of glutathione transferase T2-2 Academic Article
FeMo cofactor of nitrogenase: a density functional study of states M(N), M(OX), M(R), and M(I) Academic Article
Features of subunit nuom (nd4) in escherichia coli ndh-1 topology and implication of conserved glu(144) for coupling site 1 Academic Article
Fibrinolytic system of cultured endothelial cells: regulation by plasminogen activator inhibitor Academic Article
Fibronectin type III domains engineered to bind CD40L: cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of two complexes Academic Article
Fine definition of the CXCR4-binding region on the V3 loop of feline immunodeficiency virus surface glycoprotein Academic Article
Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120 Academic Article
Fine tuning a molecular motor: The location of alternative domains in the drosophila myosin head Academic Article
Flavin adenine dinucleotide chromophore charge controls the conformation of cyclobutane pyrimidine dimer photolyase alpha-helices Academic Article
Flavonol activation defines an unanticipated ligand-binding site in the kinase-rnase domain of ire1 Academic Article
Flexibility in the ABC transporter MsbA: Alternating access with a twist Academic Article
Flipping of alkylated DNA damage bridges base and nucleotide excision repair Academic Article
Fluorescence and nuclear relaxation enhancement studies of the binding of glutathione derivatives to manganese-reconstituted glyoxalase I from human erythrocytes. A model for the catalytic mechanism of the enzyme involving a hydrated metal ion Academic Article
Fluorescent probes for conformational states of proteins. Iv. The pepsinogen-pepsin conversion Academic Article
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing Academic Article
Folate binding site of flavin-dependent thymidylate synthase Academic Article
FoldGPCR: Structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A Academic Article
Formation of a novel four-helix bundle and molecular recognition sites by dimerization of a response regulator phosphotransferase Academic Article
Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1 Academic Article
Formation of complement subcomponent c1q immunoglobulin-g complex - thermodynamic and chemical-modification studies Academic Article
Formation of hybrid concanavalin-a molecules by subunit exchange Academic Article
Formation of two classes of tRNA synthetases in relation to editing functions and genetic code Academic Article
Fragment-based screen against HIV protease Academic Article
From BACE1 inhibitor to multifunctionality of tryptoline and tryptamine triazole derivatives for Alzheimer's disease Academic Article
From benchmarking HITS-CLIP peak detection programs to a new method for identification of miRNA-binding sites from Ago2-CLIP data Academic Article
From molecular diversity to catalysis: lessons from the immune system Academic Article
Full-length archaeal rad51 structure and mutants: Mechanisms for rad51 assembly and control by brca2 Academic Article
Function independence of microhelix aminoacylation from anticodon binding in a class I tRNA synthetase Academic Article
Functional activation of integrin αvβ3 in tumor cells expressing membrane-type 1 matrix metalloproteinase Academic Article
Functional analysis of peptide motif for RNA microhelix binding suggests new family of RNA-binding domains Academic Article
Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein Academic Article
Functional analysis suggests unexpected role for conserved active-site residue in enzyme of known structure Academic Article
Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase Academic Article
Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering Academic Article
Functional assembly of a randomly cleaved protein Academic Article
Functional cavitands: Chemical reactivity in structured environments Academic Article
Functional cis-heterodimers of N- and R-cadherins Academic Article
Functional contacts of a transfer RNA synthetase with 2'-hydroxyl groups in the RNA minor groove Academic Article
Functional dissection of a predicted class-defining motif in a class II tRNA synthetase of unknown structure Academic Article
Functional dissection of circadian clock- and phytochrome-regulated transcription of the Arabidopsis CAB2 gene Academic Article
Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3 Academic Article
Functional interrogation of the kinome using nucleotide acyl phosphates Academic Article
Functional mimicry of a protein hormone by a peptide agonist: The epo receptor complex at 2.8 Å Academic Article
Functional modulation of the isolated glycoprotein Ib binding domain of von Willebrand factor expressed in Escherichia coli Academic Article
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes Academic Article
Functional redundancy in the nonspecific RNA binding domain of a class I tRNA synthetase Academic Article
Functional role for a conserved aspartate in the spo0e signature motif involved in the dephosphorylation of the bacillus subtilis sporulation regulator spo0a Academic Article
Functional roles for the striatal-enriched transcription factor, bcl11b, in the control of striatal gene expression and transcriptional dysregulation in huntington's disease Academic Article
Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1. Academic Article
Functional studies and homology modeling of Msh2-Msh3 predict that mispair recognition involves DNA bending and strand separation Academic Article
Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface Academic Article
Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein e2c direct integration of viral DNA into specific sites Academic Article
GIGANTEA directly activates Flowering Locus T in Arabidopsis thaliana Academic Article
GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex Academic Article
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function Academic Article
Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B Academic Article
Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors Academic Article
Gating mechanisms of acid-sensing ion channels Academic Article
Gene transcription through activation of G-protein-coupled chemoattractant receptors Academic Article
Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration Academic Article
Generation and characterization of specific antibodies directed to the binding domain of adhesive molecules Academic Article
Generation of a Ni(II) binding site by introduction of a histidine cluster in the structure of human glutathione transferase A1-1 Academic Article
Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe Academic Article
Genetic introduction of a diketone-containing amino acid into proteins Academic Article
Genetic selection of short peptides that support protein oligomerization in vivo Academic Article
Genetically encoded fragment-based discovery of glycopeptide ligands for carbohydrate-binding proteins Academic Article
Genome-wide analysis of CREB target genes reveals a core promoter requirement for camp responsiveness Academic Article
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues Academic Article
Genome-wide analysis reveals padi4 cooperates with elk-1 to activate c-fos expression in breast cancer cells Academic Article
Genome-wide identification of bcl11b gene targets reveals role in brain-derived neurotrophic factor signaling Academic Article
Genome-wide nucleosome mapping of plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes Academic Article
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma Academic Article
Genomic effects of polyamide/DNA interactions on mRNA expression Academic Article
Genomic-scale comparison of sequence- and structure-based methods of function prediction: Does structure provide additional insight? Academic Article
Global structural changes in hepatitis b virus capsids induced by the assembly effector hap1 Academic Article
Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles Academic Article
Glutathione transferases in the bioactivation of azathioprine Academic Article
Glutathione transferases with novel active sites isolated by phage display from a library of random mutants Academic Article
Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2 Academic Article
Glycoproteins of plasma-membrane of dictyostelium discoideum during development Academic Article
Glycosaparaginase from human leukocytes. Inactivation and covalent modification with diazo-oxonorvaline Academic Article
Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin Academic Article
Gp120: Biologic aspects of structural features Academic Article
Gpcr agonist binding revealed by modeling and crystallography Academic Article
Growth hormone releasing substances: types and their receptors Academic Article
H-1 NMR-studies at 360 mhz of aromatic amino-acid residues in ferrocytochrome c-552 from euglena-gracilis Academic Article
H-1 NMR-studies at 360 mhz of methyl-groups in native and chemically modified basic pancreatic trypsin-inhibitor (bpti) Academic Article
H-1 NMR-studies of heme iron coordination in cytochrome c-552 from euglena-gracilis Academic Article
H-1, n-15 and c-13 resonance assignments, secondary structure, and the conformation of substrate in the binary folate complex of escherichia-coli dihydrofolate-reductase Academic Article
H-1, n-15, and c-13 backbone chemical-shift assignments, secondary structure, and magnesium-binding characteristics of the bacillus-subtilis response regulator, spoof, determined by heteronuclear high-resolution NMR Academic Article
H-1-NMR studies of the coordination geometry at the heme iron and the electronic-structure of the heme group in cytochrome-c-552 from euglena-gracilis Academic Article
HCV NS5A and IRF9 compete for CypA binding Academic Article
HCV core residues critical for infectivity are also involved in core-NS5A complex formation Academic Article
HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors Academic Article
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites Academic Article
HIV-1 mRNA 3' end processing is distinctively regulated by elF3f, CDK11, and splice factor 9G8 Academic Article
HY5, Circadian Clock-Associated 1, and a cis-element, DET1 dark response element, mediate DET1 regulation of chlorophyll a/b-binding protein 2 expression Academic Article
Heat stress activates fission yeast Spc1/StyI MAPK by a MEKK-independent mechanism Academic Article
Helix 11 dynamics is critical for constitutive androstane receptor activity Academic Article
Hemagglutinin homologue from h17n10 bat influenza virus exhibits divergent receptor-binding and ph-dependent fusion activities Academic Article
Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins b cell linker protein and slp-76 in lymphocytes Academic Article
Heme stoichiometry of heterodimeric soluble guanylate cyclase Academic Article
Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms Academic Article
Hepatitis C virus E2 envelope glycoprotein core structure Academic Article
Hepatocyte nuclear factor-4-independent synthesis of coagulation factor vii in breast cancer cells and its inhibition by targeting selective histone acetyltransferases Academic Article
Heterocyclic derivatives of 2-(3,5-dimethylphenyl)tryptamine as GnRH receptor antagonists Academic Article
Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation Academic Article
Hif2 alpha-sp1 interaction mediates a deacetylation-dependent fvii-gene activation under hypoxic conditions in ovarian cancer cells Academic Article
High affinity targets of protein kinase inhibitors have similar residues at the positions energetically important for binding Academic Article
High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes Academic Article
High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA Academic Article
High resolution structure of the ba3 cytochrome c oxidase from thermus thermophilus in a lipidic environment Academic Article
High throughput screening of potentially selective mmp-13 exosite inhibitors utilizing a triple-helical fret substrate Academic Article
High-affinity consensus binding of target RNAs by the STAR/GSG proteins GLS-1, STAR-2 and quaking Academic Article
High-affinity self-reactive human-antibodies by design and selection - targeting the integrin ligand-binding site Academic Article
High-resolution capillary zone and gel electrophoresis of structurally similar amphipathic glutathione conjugates based on interaction with beta-cyclodextrins Academic Article
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Academic Article
High-resolution definition of vaccine-elicited b cell responses against the hiv primary receptor binding site Academic Article
High-resolution functional proteomics by active-site peptide profiling Academic Article
High-resolution solution structure of bacillus subtilis iia(glc) Academic Article
High-resolution solution structure of the retinoid X receptor DNA-binding domain Academic Article
Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters Academic Article
Highly selective cyclic peptide ligands for NeutrAvidin and avidin identified by phage display Academic Article
Histones f2a1 and f3 interact reversibly and cooperatively with DNA to form an equimolar complex in chromatin Academic Article
Hla-dependent expression of testis-organizing h-y antigen by human male cells Academic Article
Homology between the DNA-binding domain of the gcn4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun Academic Article
Homology-model-guided site-specific mutagenesis reveals the mechanisms of substrate binding and product-regulation of adenosine kinase from Leishmania donovani Academic Article
Host-guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents Academic Article
Hotspot-centric de novo design of protein binders Academic Article
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How does the GAL4 transcription factor recognize the appropriate DNA binding sites in vivo? Academic Article
HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis Academic Article
Human IL-1-beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA Academic Article
Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses Academic Article
Human antibody effector function Academic Article
Human ckshs2 atomic-structure - a role for its hexameric assembly in cell-cycle control Academic Article
Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues Academic Article
Human dutp pyrophosphatase: Uracil recognition by a beta hairpin and active sites formed by three separate subunits Academic Article
Human fc-gamma-ri and fc-gamma-rii interact with distinct but overlapping sites on human-igg Academic Article
Human glutathione transferase a4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products Academic Article
Human immunodeficiency virus envelope (gp120) binding to dc-sign and primary dendritic cells is carbohydrate dependent but does not involve 2g12 or cyanovirin binding sites: Implications for structural analyses of gp120-dc-sign binding Academic Article
Human immunodeficiency virus matrix tyrosine phosphorylation: Characterization of the kinase and its substrate requirements Academic Article
Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein e2c can bias integration of viral DNA into a predetermined chromosomal region in human cells Academic Article
Human mitochondrial manganese superoxide dismutase polymorphic variant ile58thr reduces activity by destabilizing the tetrameric interface Academic Article
Human neural cell adhesion molecule l1 and rat homologue nile are ligands for integrin alpha(v)beta(3) Academic Article
Human rhinovirus capsid dynamics is controlled by canyon flexibility Academic Article
Hybrid cytochromes P-450 identify a substrate binding domain in P-450IIC5 and P-450IIC4 Academic Article
Hybridization of alpha class subunits generating a functional glutathione transferase A1-4 heterodimer Academic Article
Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine Academic Article
Hydrogen-deuterium exchange strategy for delineation of contact sites in protein complexes Academic Article
Hydrogen/deuterium-exchange (H/D-Ex) of PPAR gamma LBD in the presence of various modulators Academic Article
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Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis Academic Article
Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies Academic Article
Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif Academic Article
Hypoxia-inducible factor 1α (HIF-1α)-mediated hypoxia increases BACE1 expression and β-amyloid generation Academic Article
Identical components of yeast transcription factor IIIB are required and sufficient for transcription of TATA box-containing and TATA-less genes Academic Article
Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III Academic Article
Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways Academic Article
Identification and cross-species comparison of canine osteoarthritic gene regulatory cis-elements Academic Article
Identification and design of p53-derived HLA-A2-binding peptides with increased CTL immunogenicity Academic Article
Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA Academic Article
Identification and structure-activity relationships of a new series of Melanocortin-4 receptor antagonists Academic Article
Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the α2δ-1 subunit of voltage gated calcium channel Academic Article
Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase Academic Article
Identification of 50S components neighboring 23S rRNA nucleotides A2448 and U2604 within the peptidyl transferase center of Escherichia coli ribosomes Academic Article
Identification of GABA(c) receptor protein homeostasis network components from three tandem mass spectrometry proteomics approaches Academic Article
Identification of Gal4 activation domain-binding proteins in the 26S proteasome by periodate-triggered cross-linking Academic Article
Identification of Phe(313) of the gonadotropin-releasing hormone (GnRH) receptor as a site critical for the binding of nonpeptide GnRH antagonists Academic Article
Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB Academic Article
Identification of a lipid-a binding-site in the acute phase reactant lipopolysaccharide binding-protein Academic Article
Identification of a minimal domain of 5 S ribosomal RNA sufficient for high affinity interactions with the RNA-specific zinc fingers of transcription factor IIIA Academic Article
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Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein Academic Article
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Identification of a p53 binding-site in the human retinoblastoma susceptibility gene promoter Academic Article
Identification of a putative steroidogenic factor-i response element in the dax-1 promoter Academic Article
Identification of a regulatory domain of the interleukin-6 receptor Academic Article
Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding Academic Article
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT) Academic Article
Identification of an N-formyl peptide receptor ligand binding domain by a gain-of-function approach Academic Article
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Identification of an epitope of alpha-enolase (a candidate plasminogen receptor) by phage display Academic Article
Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors Academic Article
Identification of covalent bromodomain binders through DNA display of small molecules Academic Article
Identification of critical active-site residues in the multifunctional human DNA-repair enzyme hap1 Academic Article
Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin. A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib Academic Article
Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays Academic Article
Identification of endogenous ligands bound to bacterially expressed human and E. coli dihydrofolate reductase by 2D NMR Academic Article
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Identification of inhibitors of the E. coli chaperone SurA using in silico and in vitro techniques Academic Article
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Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility Academic Article
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Identification of the nadh-binding subunit of nadh-ubiquinone oxidoreductase of paracoccus-denitrificans Academic Article
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Identification of transcription factor binding sites in the human genome sequence Academic Article
Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides Academic Article
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Immunological and binding studies on chloroform--methanol extracts from electroplax of Torpedo marmorata and from rat brain cortex. Comparison of the material solubilized by organic solvents with the receptor proteins solubilized by detergents Academic Article
Immunological memory to hyperphosphorylated tau in asymptomatic individuals Academic Article
Immunological mimicry by a monoclonal-antibody of the tricyclic anti-depressants binding-site on muscarinic acetylcholine-receptors Academic Article
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Immunoregulatory plasma low-density lipoprotein - the biologic activity and receptor-binding specificity is independent of neutral lipids Academic Article
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Improved design of an antigen with enhanced specificity for the broadly hiv-neutralizing antibody b12 Academic Article
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Improved model building and assessment of the Calcium-sensing receptor transmembrane domain Academic Article
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In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the opca outer membrane adhesin Academic Article
In silico screening against wild-type and mutant Plasmodium falciparum dihydrofolate reductase Academic Article
In situ selection of lead compounds by click chemistry: Target-guided optimization of acetylcholinesterase inhibitors Academic Article
In vitro analysis of nuclear transport mediated by the c-terminal shuttle domain of tap Academic Article
In vitro selection of nucleic acids and proteins: what are we learning? Academic Article
In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for icam-1 provides new insights into gene regulation Academic Article
In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase Academic Article
In vivo, in vitro, and molecular aspects of interleukin-8 and the interleukin-8 receptors Academic Article
In-line separation by capillary electrophoresis prior to analysis by top-down mass spectrometry enables sensitive characterization of protein complexes Academic Article
In-vitro evolution of a neutralizing human-antibody to human-immunodeficiency-virus type-1 to enhance affinity and broaden strain cross-reactivity Academic Article
Inactivation of beta-adrenergic receptors by n-ethylmaleimide - permissive role of beta-adrenergic agents in relation to adenylate-cyclase activation Academic Article
Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A Academic Article
Increasing protein stability using a rational approach combining sequence homology and structural alignment: stabilizing the WW domain Academic Article
Independent assembly and secretion of a dimeric adhesive domain of von Willebrand factor containing the glycoprotein Ib-binding site Academic Article
Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody Academic Article
Individual h-1-NMR assignments for the heme groups and the axially bound amino-acids and determination of the coordination geometry at the heme iron in a mixture of 2 isocytochromes-c-551 from rhodopseudomonas-gelatinosa Academic Article
Inducible nitric oxide synthase: Role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction Academic Article
Influence of cargo size on ran and energy requirements for nuclear protein import Academic Article
Influence of cofactor binding and active site occupancy on the conformation of the macromolecular substrate exosite of factor viia Academic Article
Influence of electronic and structural effects on the oxidative behavior of nickel porphyrins Academic Article
Influence of novel cd4 binding-defective hiv-1 envelope glycoprotein immunogens on neutralizing antibody and t-cell responses in nonhuman primates Academic Article
Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein Academic Article
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Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors Academic Article
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Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-kappa B, and DNA by a designed DNA-binding ligand Academic Article
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Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands Academic Article
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Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin Academic Article
Interactions and inhibition of blood-coagulation factor-Va involving residues 311-325 of activated protein-C Academic Article
Interactions of Qβ replicase with Qβ RNA Academic Article
Interactions of active-site residues and catalytic activity of human carbonic anhydrase III Academic Article
Interactions of bovine neurophysin-II with oxytocin and 8-lysine vasopressin - high-resolution proton nuclear magnetic-resonance spectroscopy studies Academic Article
Interactions of soluble recombinant integrin alpha v beta 5 with human adenoviruses Academic Article
Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression Academic Article
Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta (C/EBP beta) Academic Article
Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue Academic Article
Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin Academic Article
Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells Academic Article
Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase Academic Article
Investigation of the PDZ domain ligand binding site using chemically modified peptides Academic Article
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters Academic Article
Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein Academic Article
Involvement of an active-site Zn2+ ligand mechanism of human glyoxalase I Academic Article
Iron superoxide-dismutase from escherichia-coli at 3.1-a resolution - a structure unlike that of copper-zinc protein at both monomer and dimer levels Academic Article
Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? Academic Article
Isoform-selective and stereoselective inhibition of hypoxia inducible factor-2 Academic Article
Isolated RNA binding domain of a class I tRNA synthetase Academic Article
Isolation and characterization of a collagen binding domain in human von Willebrand factor Academic Article
Isolation and characterization of maclura pomifera (mp) lectin Academic Article
Isolation and characterization of the DNA and protein binding activities of adenovirus core protein V Academic Article
Isolation and functional characterization of the von Willebrand factor-binding domain located between residues His1-Arg293 of the alpha-chain of glycoprotein Ib Academic Article
Isolation and sequence-specific DNA-binding of the antennapedia homeodomain Academic Article
Isolation of lectins of different specificities on a single affinity adsorbent Academic Article
Isolation of the von Willebrand factor domain interacting with platelet glycoprotein Ib, heparin, and collagen and characterization of its three distinct functional sites Academic Article
Isothermal titration calorimetry and surface plasmon resonance allow quantifying substrate binding to different binding sites of Bacillus subtilis xylanase Academic Article
Isotope labeling of free and aminoacyl transfer RNA synthetase-bound transfer RNA Academic Article
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress Academic Article
Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein tpr Academic Article
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP Academic Article
Kinetic analysis of integrin-dependent cell adhesion on vitronectin: the inhibitory potential of plasminogen activator inhibitor-1 and RGD peptides Academic Article
Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase Academic Article
Kinetic analysis of the interaction between type 1 plasminogen activator inhibitor and vitronectin and evidence that the bovine inhibitor binds to a thrombin-derived amino-terminal fragment of bovine vitronectin Academic Article
Kinetic analysis of the interaction between vitronectin and the urokinase receptor Academic Article
Kinetic and spectroscopic evidence for three actomyosin : Adp states in smooth muscle Academic Article
Kinetic and stoichiometric characterisation of streptavidin-binding aptamers Academic Article
Kinetic independence of the subunits of cytosolic glutathione transferase from the rat Academic Article
Kinetic intermediates trapped by native interactions in RNA folding Academic Article
Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3 alpha 1 Academic Article
Kinetic mechanism of RGS9-1 potentiation by R9AP Academic Article
Kinetics and mechanisms of reduction of cu(ii) and fe(iii) complexes by soybean leghemoglobin-alpha Academic Article
Kinetics and mechanisms of the oxidation of myoglobin by fe(iii) and cu(ii) complexes Academic Article
Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of udp-glcnac enolpyruvoyl transferase by the antibiotic fosfomycin Academic Article
Kinomics-structural biology and chemogenomics of kinase inhibitors and targets Academic Article
Kinomics: Characterizing the therapeutically validated kinase space Academic Article
L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding Academic Article
L-a virus at 3.4 Å resolution reveals particle architecture and mrna decapping mechanism Academic Article
Lack of complex i activity in human cells carrying a mutation in mtdna-encoded nd4 subunit is corrected by the saccharomyces cerevisiae nadh-quinone oxidoreductase (ndi1) gene Academic Article
Lactose binding induces opposing dynamics changes in human galectins revealed by NMR-based hydrogen-deuterium exchange Academic Article
Large conformational changes in the maturation of a simple rna virus, nudaurelia capensis omega virus (n omega v) Academic Article
Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response Academic Article
Leu5enkephalin-encoding sequences are targets for a specific DNA-binding factor. Academic Article
Leu628 of the kix domain of cbp is a key residue for the interaction with the mll transactivation domain Academic Article
Ligand accessibility to the HIV-1 Env co-receptor binding site can occur prior to CD4 engagement and is independent of viral tier category Academic Article
Ligand activation of ERRα by cholesterol mediates statin and bisphosphonate effects Academic Article
Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues Academic Article
Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening Academic Article
Ligand-dependent perturbation of the conformational ensemble for the GPCR beta(2) adrenergic receptor revealed by HDX Academic Article
Ligand-guided receptor optimization Academic Article
Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor Academic Article
Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation Academic Article
Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms Academic Article
Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate Academic Article
Like-acetylglucosaminyltransferase (large)-dependent modification of dystroglycan at thr-317/319 is required for laminin binding and arenavirus infection Academic Article
Linear and cyclic N-terminal galanin fragments and analogs as ligands at the hypothalamic galanin receptor Academic Article
Linear combinations of docking affinities explain quantitative differences in RTK signaling Academic Article
Linking folding and binding Academic Article
Lipid binding promotes oligomerization and focal adhesion activity of vinculin Academic Article
Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells - regulation by egr-1, c-jun, and nf-kappa b transcription factors Academic Article
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2 Academic Article
Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in thp-1 monocytic cells requires both activator protein-1 and nuclear factor-kappa-b binding-sites Academic Article
Lipoprotein complex of equine lysozyme with oleic acid (eloa) interactions with the plasma membrane of live cells Academic Article
Liver x receptor-retinoid x receptor (lxr-rxr) heterodimer cistrome reveals coordination of lxr and ap1 signaling in keratinocytes Academic Article
Local folding coupled to RNA binding in the yeast ribosomal protein L30 Academic Article
Localization of carbohydrate attachment sites and disulfide bridges in limulus alpha(2)-macroglobulin - evidence for two forms differing primarily in their bait region sequences Academic Article
Localization of membrane permeabilization and receptor binding sites on the vp4 hemagglutinin of rotavirus: Implications for cell entry Academic Article
Localization of sites of interaction between p23 and hsp90 in solution Academic Article
Localization of the binding-site for the human high-affinity fc receptor on igg Academic Article
Localization of the heme binding region in soluble guanylate cyclase Academic Article
Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity Academic Article
Location of high-affinity metal-binding sites in the profile structure of the Ca+2-ATPase in the sarcoplasmic-reticulum by resonance x-ray-diffraction Academic Article
Location of the saccharide binding site of concanavalin a Academic Article
Location, degree, and direction of DNA bending associated with the Hin recombinational enhancer sequence and Fis-enhancer complex Academic Article
Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase Academic Article
Lung Kruppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase Academic Article
Lysis of human cultured lymphoblastoid cells by cell-induced activation of properdin pathway Academic Article
M-15: high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus, and spinal cord Academic Article
MDB: The metalloprotein database and browser at The Scripps Research Institute Academic Article
Mafa has strong cell transforming ability but is a weak transactivator Academic Article
Magnetic-properties of cobalt substituted bovine superoxide-dismutase derivatives Academic Article
Maintaining genetic code through adaptations of tRNA synthetases to taxonomic domains Academic Article
Major anticodon-binding region missing from an archaebacterial tRNA synthetase Academic Article
Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape Academic Article
Malachite green mediates homodimerization of antibody VL domains to form a fluorescent ternary complex with singular symmetric interfaces Academic Article
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation Academic Article
Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity Academic Article
Manipulation of thrombin exosite I, by ligand-directed covalent modification Academic Article
Map2 and tau bind longitudinally along the outer ridges of microtubule protofilaments Academic Article
Map2c, but not tau, binds via its microtubule binding and bundles f-actin domain Academic Article
Mapkk-independent activation of p38 alpha mediated by tab1-dependent autophosphorylation of p38 alpha Academic Article
Mapping a common interaction site used by plasmodium falciparum duffy binding-like domains to bind diverse host receptors Academic Article
Mapping binding residues in the Plasmodium vivax domain that binds Duffy antigen during red cell invasion Academic Article
Mapping determinants of the substrate selectivities of P450 enzymes by site-directed mutagenesis Academic Article
Mapping enzyme active sites in complex proteomes Academic Article
Mapping interactions between the rna chaperone fino and its rna targets Academic Article
Mapping of distinct von Willebrand factor domains interacting with platelet GPIb and GPIIb/IIIa and with collagen using monoclonal antibodies Academic Article
Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, hpr and iia(glc) Academic Article
Mapping of the cxcr4 binding site within variable region 3 of the feline immunodeficiency virus surface glycoprotein Academic Article
Mapping the binding site of BMS-708163 on γ-secretase with cleavable photoprobes Academic Article
Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo Academic Article
Mapping the interactions of the p53 transactivation domain with the kix domain of cbp Academic Article
Mapping the transition state of the WW domain beta-sheet Academic Article
Measles virus recognizes its receptor, cd46, via two distinct binding domains within scr1-2 Academic Article
Measles-virus and c3 binding-sites are distinct on membrane cofactor protein (cd46) Academic Article
Mechanism and atomic structure of superoxide dismutase Academic Article
Mechanism of Action of an Imidopiperidine Inhibitor of Human Polynucleotide Kinase/Phosphatase Academic Article
Mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia: Role of the nucleotide positioning loop Academic Article
Mechanism of binding site conformational switching in the CD44-hyaluronan protein-carbohydrate binding interaction Academic Article
Mechanism of drug inhibition and drug resistance of influenza A M2 channel Academic Article
Mechanism of human alpha-1,3-fucosyltransferase v: Glycosidic cleavage occurs prior to nucleophilic attack Academic Article
Mechanism of microtubule stabilization by doublecortin Academic Article
Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01 Academic Article
Mechanism of thioflavin T binding to amyloid fibrils Academic Article
Mechanism-based phage display selection of active-site mutants of human glutathione transferase A1-1 catalyzing SNAr reactions Academic Article
Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate Academic Article
Mechanisms of spectral tuning in blue cone visual pigments. Visible and raman spectroscopy of blue-shifted rhodopsin mutants Academic Article
Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides Academic Article
Mechanistic implications of pseudo zero order kinetics in kinetic resolutions Academic Article
Mechanistic studies of beta-arylsulfotransferase iv Academic Article
Mediator structural conservation and implications for the regulation mechanism Academic Article
Membrane-associated DNA in the cytoplasm of diploid human lymphocytes Academic Article
Merlin, the product of the Nf2 tumor suppressor gene, the p21-activated is an inhibitor of kinase, Pak1 Academic Article
Metal stoichiometry and functional studies of the diphtheria toxin repressor Academic Article
Metal-binding site in a class I tRNA synthetase localized to a cysteine cluster inserted into nucleotide-binding fold Academic Article
Metal-binding sites in proteins Academic Article
Metalloantibody design Academic Article
Methionine ligand interaction in a blue copper protein characterized by site-selective infrared spectroscopy Academic Article
Microarray platform for profiling enzyme activities in complex proteomes Academic Article
Microbial glycan microarrays define key features of host-microbial interactions Academic Article
Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features Academic Article
Minor groove DNA-protein contacts upstream of a tRNA gene detected with a synthetic DNA binding ligand Academic Article
Minor groove recognition of the critical acceptor helix base pair by an appended module of a class II tRNA synthetase Academic Article
Misactivated amino acids translocate at similar rates across surface of a tRNA synthetase Academic Article
Model building and refinement of a natively glycosylated HIV-1 Env protein by high-resolution cryoelectron microscopy Academic Article
Model of the alpha L beta 2 integrin I-domain/ICAM-1 DI interface suggests that subtle changes in loop orientation determine ligand specificity Academic Article
Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues Academic Article
Models of the serine-protease domain of the human antithrombotic plasma factor-activated protein-C and its zymogen Academic Article
Modes of peptide binding in G protein-coupled receptors Academic Article
Modification of the binding site for pyridine nucleotides of glutathione reductase by 2,3-butanedione Academic Article
Modular arrangement of functional domains along the sequence of an aminoacyl tRNA synthetase Academic Article
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ib-alpha Academic Article
Modulation of lymphocyte receptor mobility by locally bound concanavalin-a Academic Article
Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase Academic Article
Molecular analysis of the interaction of lcmv with its cellular receptor alpha-dystroglycan Academic Article
Molecular basis for p38 protein kinase inhibitor specificity Academic Article
Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity Academic Article
Molecular basis for the generation in pigs of influenza a viruses with pandemic potential Academic Article
Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta Academic Article
Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition Academic Article
Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C Academic Article
Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions Academic Article
Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein Academic Article
Molecular cloning of Limulus alpha 2-macroglobulin Academic Article
Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P Academic Article
Molecular determinants of lxr alpha agonism Academic Article
Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3 Academic Article
Molecular docking programs successfully predict the binding of a beta-lactamase inhibitory protein to TEM-1 beta-lactamase Academic Article
Molecular editing of kinase-targeting resorcylic acid lactones (RAL): Fluoroenone RAL Academic Article
Molecular evolution of antibody cross-reactivity for two subtypes of type a botulinum neurotoxin Academic Article
Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120 Academic Article
Molecular mechanism for the umami taste synergism Academic Article
Molecular mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia - roles of conserved active site residues Academic Article
Molecular mechanism of the sweet taste enhancers Academic Article
Molecular modeling and crystal structure of ERK2-hypothemycin complexes Academic Article
Molecular probes of spermatozoan structures Academic Article
Molecular recognition and binding free energy calculations in drug development Academic Article
Molecular recognition by the Candida albicans group I intron: tertiary interactions with an imino G.A pair facilitate binding of the 5' exon and lower the KM for guanosine Academic Article
Molecular recognition in signal transduction: The interaction surfaces of the spo0f response regulator with its cognate phosphorelay proteins revealed by alanine scanning mutagenesis Academic Article
Molecular recognition of 6 '-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches Academic Article
Molecular recognition of insulin by a synthetic receptor Academic Article
Molecular recognition: model studies with convergent functional groups Academic Article
Molecular-cloning of the cdna-encoding the epstein-barr virus/c3d receptor (complement receptor type-2) of human lymphocytes-b Academic Article
Molecular-genetic and protein chemical characterization of the cytochrome ba(3) from thermus-thermophilus hb8 Academic Article
Molecular-structure of f-actin and location of surface binding-sites Academic Article
Monoclonal antibodies against receptor-induced binding sites detect cell-bound plasminogen in blood Academic Article
Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen Academic Article
Monolayers of derivatized poly(L-lysine)-grafted poly(ethylene glycol) on metal oxides as a class of biomolecular interfaces Academic Article
Monovalet derivatives of concanavalin-a Academic Article
Motor domains of kinesin and ncd interact with microtubule protofilaments with the same binding geometry Academic Article
Multi-substrate-activity space and quasi-species in enzyme evolution: Ohno's dilemma, promiscuity and functional orthogonality Academic Article
Multifrequency epr evidence for a binuclear cu-a center in cytochrome-c-oxidase - studies with a cu-63-enriched and cu-65-enriched, soluble domain of the cytochrome-ba(3) subunit-ii from thermus-thermophilus Academic Article
Multiple adenovirus serotypes use alpha-v integrins for infection Academic Article
Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors Academic Article
Multiple epitope specificity of monoclonal antibodies to a single synthetic peptide: use in the characterization of the GP IIb-IIIa binding domain of von Willebrand factor Academic Article
Multiple replacements of glutamine 143 in human manganese superoxide dismutase: Effects on structure, stability, and catalysis Academic Article
Multiple sites on IL-8 responsible for binding to alpha and beta IL-8 receptors Academic Article
Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1 Academic Article
Mus81-Eme1 are essential components of a Holliday junction resolvase Academic Article
Muscarinic acetylcholine receptor from rat brain. Partial purification and characterization Academic Article
Mutagenesis and ligand modification studies on galanin binding to its GTP-binding-protein-coupled receptor GalR1 Academic Article
Mutagenesis of residue 157 in the active site of human glyoxalase I Academic Article
Mutagenesis study on human galanin receptor GalR1 reveals domains involved in ligand binding Academic Article
Mutation of an active site residue in escherichia coli uracil-DNA glycosylase: Effect on DNA binding, uracil inhibition and catalysis Academic Article
Mutation of an evolutionarily conserved tyrosine residue in the active site of a human class Alpha glutathione transferase Academic Article
Mutational activation of c-raf-1 and definition of the minimal transforming sequence Academic Article
Mutational analysis of 48G7 reveals that somatic hypermutation affects both antibody stability and binding affinity Academic Article
Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay Academic Article
Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine Academic Article
Mutational analysis of the active-site residues crucial for catalytic activity of adenosine kinase from Leishmania donovani Academic Article
Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase Academic Article
Mutational and biophysical studies suggest rc3/neurogranin regulates calmodulin availability Academic Article
Mutational isolation of a sieve for editing in a transfer RNA synthetase Academic Article
Mutational mapping of functional residues in tissue factor - identification of factor-vii recognition determinants in both structural modules of the predicted cytokine receptor homology domain Academic Article
Mutational separation of two pathways for editing by a class I tRNA synthetase Academic Article
Mutations in the G-domain of elongation factor G from thermus thermophilus affect both its interaction with GTP and fusidic acid Academic Article
Mycoplasma-arthritidis mitogen -V-beta engaged in mice, rats, and humans, and requirement of HLA-DR-alpha for presentation Academic Article
N-(arylacetyl)-biphenylalanines as potent vla-4 antagonists Academic Article
N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability Academic Article
N-terminal domain of Borna disease virus g (p56) protein is sufficient for virus receptor recognition and cell entry Academic Article
N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization Academic Article
N-terminally elongated fragments of galanin(1-16) inhibit insulin secretion from isolated mouse islets Academic Article
N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase Academic Article
N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase Academic Article
NF kappa B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Academic Article
NMR and computer modeling studies of the conformations of glutathione derivatives at the active site of glyoxalase I Academic Article
NMR and molecular dynamics studies of the hydration of a zinc finger-DNA complex Academic Article
NMR assignment of the spinophilin PDZ domain (493-602) Academic Article
NMR solution structure of Cu(I) rusticyanin from Thiobacillus ferrooxidans: structural basis for the extreme acid stability and redox potential Academic Article
NMR solution structure of the inserted domain of human leukocyte function associated antigen-1 Academic Article
NMR structure of a cyclic polyamide-DNA complex Academic Article
NMR structures of α-proteobacterial ATPase-regulating ζ-subunits Academic Article
NMR studies of the conformations of leghemoglobins from soybean and lupin Academic Article
NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41 Academic Article
Na-23 NMR as a probe of ion binding to chromatin Academic Article
Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: A focus on the transthyretin amyloidoses Academic Article
Natural resistance of human immunodeficiency virus type 1 to the cd4bs antibody b12 conferred by a glycan and an arginine residue close to the cd4 binding loop Academic Article
Natural supramolecular building blocks: Cysteine-added mutants of cowpea mosaic virus Academic Article
Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells Academic Article
Nature's inventory of halogenation catalysts: Oxidative strategies predominate Academic Article
Negative regulation of human c-fos expression by the retinoblastoma gene-product Academic Article
Negative regulation of the major histocompatibility complex class-I enhancer in adenovirus type 12-transformed cell via a retinoic acid response element Academic Article
Negative stain single-particle EM of the maltose transporter in nanodiscs reveals asymmetric closure of MalK2 and catalytic roles of ATP, MalE, and maltose Academic Article
Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle Academic Article
Networks link antigenic and receptor-binding sites of influenza hemagglutinin: Mechanistic insight into fitter strain propagation Academic Article
Neurite fasciculation mediated by complexes of axonin-1 and Ng cell adhesion molecule Academic Article
Neuronal expression of a functional receptor for the C5a complement activation fragment Academic Article
Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity Academic Article
Neutralizing mutations of carboxylates that bind metal 2 in t5 flap endonuclease result in an enzyme that still requires two metal ions Academic Article
New chemistry for the study of multiprotein complexes: The six-histidine tag as a receptor for a protein crosslinking reagent Academic Article
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix Academic Article
New evidence on location of saccharide-binding site of concanavalin-a Academic Article
New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: analysis of the epidermal growth factor-like repeat A docking site using WaterMap Academic Article
Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1 Academic Article
Nickel superoxide dismutase structure and mechanism Academic Article
Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells Academic Article
Nitric oxide binding to prokaryotic homologs of the soluble guanylate cyclase beta 1 h-nox domain Academic Article
Nitric oxide synthase stabilizes the tetrahydrobiopterin cofactor radical by controlling its protonation state Academic Article
Nitrosyl-heme structures of Bacillus subtilis nitric oxide synthase have implications for understanding substrate oxidation Academic Article
Nmr and kinetic characterization of the interaction between french bean plastocyanin and horse cytochrome-c Academic Article
Nmr spectroscopic studies of the DNA-binding domain of the monomer-binding nuclear orphan receptor, human estrogen related receptor-2 - the carboxyl-terminal extension to the zinc-finger region is unstructured in the free form of the protein Academic Article
Nmr structure and metal interactions of the copz copper chaperone Academic Article
Nmr structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the drosophila antennapedia protein Academic Article
Nmr structure of the conserved hypothetical protein tm0487 from thermotoga maritima: Implications for 216 homologous duf59 proteins Academic Article
Nmr structure of the human oncofoetal fibronectin ed-b domain, a specific marker for angiogenesis Academic Article
Nmr structure reveals intramolecular regulation mechanism for pheromone binding and release Academic Article
Nmr structures of salt-refolded forms of the 434-repressor DNA-binding domain in 6 m urea Academic Article
Nmr studies of subunit c of the atp synthase from propionigenium modestum in dodecylsulphate micelles Academic Article
Nmr-derived dynamic aspects of n-type inactivation of a kv channel suggest a transient interaction with the t1 domain Academic Article
Nmr-studies of molecular-conformations in linear oligopeptides h-(l-ala)n-l-pro-oh Academic Article
No formation by a catalytically self-sufficient bacterial nitric oxide synthase from sorangium cellulosum Academic Article
Nob1 binds the single-stranded cleavage site d at the 3 '-end of 18s rRNA with its pin domain Academic Article
Non-degradative ubiquitination of protein kinases Academic Article
Nonessential active-site residues modulate selenosubtilisins kinetic mechanism Academic Article
Nonneutralizing antibodies to the cd4-binding site on the gp120 subunit of human immunodeficiency virus type 1 do not interfere with the activity of a neutralizing antibody against the same site Academic Article
Normal hydrocarbons tumble rapidly in a deep, water-soluble cavitand Academic Article
Novel DNA binding specificities of a putative herpesvirus bzip oncoprotein Academic Article
Novel DNA-binding motifs in the DNA-repair enzyme endonuclease-iii crystal-structure Academic Article
Novel analogues of (R)-5-(methylamino)-5,6-dihydro-4H-imidazo 4,5,1-ij quinolin-2(1H)-one (sumanirole) provide clues to dopamine D-2/D-3 receptor agonist selectivity Academic Article
Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase Academic Article
Novel isoform of insulin receptor substrate p53/p58 is generated by alternative splicing in the crib/sh3-binding region Academic Article
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity Academic Article
Novel sequence determinants in peroxisome proliferator signaling Academic Article
Novel vinculin binding site of the IpaA invasin of Shigella Academic Article
Novel-approach to water proton relaxation in paramagnetic ion macromolecule complexes Academic Article
Nuclear magnetic resonance (15)N and (1)H resonance assignments and global fold of rusticyanin. Insights into the ligation and acid stability of the blue copper site Academic Article
Nuclear magnetic resonance structure of a novel globular domain in RBM10 containing OCRE, the octamer repeat sequence motif Academic Article
Nuclear magnetic resonance structure of the nucleic acid-binding domain of severe acute respiratory syndrome coronavirus nonstructural protein 3 Academic Article
Nuclear magnetic resonance studies of a ribonuclease-dinucleoside phosphonate complex and their implications for the mechanism of the enzyme Academic Article
Nuclear magnetic resonance titration curves of histidine ring protons. IV. The effects of phosphate and sulfate on ribonuclease Academic Article
Nuclear receptor ligands and cofactor recruitment: is there a coactivator "on deck"? Academic Article
Nuclear receptors and their selective pharmacologic modulators Academic Article
Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer Academic Article
Nuclear relaxation studies of the role of the essential metal in glyoxalase I Academic Article
Nucleic acid encoding to program self-assembly in chemical biology Academic Article
Nucleosome interaction surface of linker histone H1c is distinct from that of H1(0) Academic Article
Nucleotide binding by the histidine kinase CheA Academic Article
Nucleotide determinants for tRNA-dependent amino acid discrimination by a class I tRNA synthetase Academic Article
Observation of an arsenic adduct in an acetyl esterase crystal structure Academic Article
Observation of covalent intermediates in an enzyme mechanism at atomic resolution Academic Article
Octahedral metal coordination in the active site of glyoxalase I as evidenced by the properties of Co(II)-glyoxalase I Academic Article
On the relationship between GC content and the number of predicted microRNA binding sites by MicroInspector Academic Article
On the role of electrostatic interactions in the design of protein-protein interfaces Academic Article
On the use of DXMS to produce more crystallizable proteins: Structures of the T. Maritima proteins TM0160 and TM1171 Academic Article
On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7 Academic Article
Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene Academic Article
Oncogenic transformation by the fox protein qin requires DNA binding Academic Article
Opposing activities of c-fos and fra-2 on ap-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters Academic Article
Optimization of adenosine 5 '-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening Academic Article
Optimization of alpha-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site Academic Article
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Organ polarity in arabidopsis. Nozzle physically interacts with members of the yabby family Academic Article
Origin of selectivity in the antibody 20f10-catalyzed yang cyclization Academic Article
Origins of enhanced proton transport in the Y7F mutant of human carbonic anhydrase II Academic Article
Orphanin FQ/nociceptin and naloxone benzoylhydrazone activate distinct receptors in BE(2)-C human neuroblastoma cells Academic Article
Oxazolomycin biosynthesis in streptomyces albus ja3453 featuring an "acyltransferase-less" type i polyketide synthase that incorporates two distinct extender units Academic Article
P21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized RHO exchange factor Academic Article
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P53 latency - c-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences Academic Article
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PDZ domains: More than just a glue Academic Article
PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45 Academic Article
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Partial agonists activate PPAR gamma using a helix 12 independent mechanism Academic Article
Partial purification and characterization of a muscarinic acetylcholine receptor from rat cerebral cortex Academic Article
Pax-3 contains domains for transcription activation and transcription inhibition Academic Article
Pbx-hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner Academic Article
Peptide ligands for a sugar-binding protein isolated from a random peptide library Academic Article
Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides Academic Article
Performance of a docking/molecular dynamics protocol for virtual screening of nutlin-class inhibitors of Mdmx Academic Article
Perspective on computational and structural aspects of kinase discovery from IPK2014 Academic Article
Pervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae Academic Article
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response Academic Article
Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels Academic Article
Phase diagrams map the properties of antiviral agents directed against hepatitis b virus core assembly Academic Article
Phospho-regulation of kinetochore-microtubule attachments by the aurora kinase Ipl1p Academic Article
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Phosphorylation of the ap2 mu subunit by aak1 mediates high affinity binding to membrane protein sorting signals Academic Article
Photo-induced joining of a transfer RNA with its cognate aminoacyl-transfer RNA synthetase Academic Article
Photoaffinity labelling of N-formyl peptide receptors Academic Article
Photoaffinity labelling of the active site of the rat glutathione transferases 3-3 and 1-1 and human glutathione transferase A1-1 Academic Article
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Physical explanation of epr-spectrum observed during catalysis by enzymes utilizing coenzyme-b12 Academic Article
Physical mapping of qbeta replicase binding-sites on qbeta rna Academic Article
Picometer-scale conformational heterogeneity separates functional from nonfunctional states of a photoreceptor protein Academic Article
Pilus chaperone fimc-adhesin fimh interactions mapped by trosy-NMR Academic Article
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Plasmalemmal insertion and modification of sodium channels at the nerve growth cone Academic Article
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Plasminogen receptors in the mediation of pericellular proteolysis Academic Article
Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway Academic Article
Platelets have more than one binding site for von Willebrand factor Academic Article
Polo-like kinases inhibited by Wortmannin. Labeling site and downstream effects Academic Article
Poly(Glu60Ala30Tyr10) (GAT)-induced IgG monoclonal-antibodies cross-react with various self and non-self antigens through the complementarity determining regions - comparison with igm monoclonal polyreactive natural antibodies Academic Article
Polymorphisms a387p in thrombospondin-4 and n700s in thrombospondin-1 perturb calcium binding sites Academic Article
Position and orientation independent transactivation by c-myc Academic Article
Positional recognition of a tRNA determinant dependent on a peptide insertion Academic Article
Positive effectors of the binding of an active site-directed amino steroid to rabbit cytochrome-P-450-3C Academic Article
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Predicting the emergence of antibiotic resistance by directed evolution and structural analysis Academic Article
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Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonist Academic Article
Preferential recognition of avian-like receptors in human influenza A H7N9 viruses Academic Article
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Presynaptic modulation of spontaneous inhibitory postsynaptic currents by gamma-hydroxybutyrate in the substantia nigra pars compacta Academic Article
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Primary structure of phage mu-transposase - homology to mu-repressor Academic Article
Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate Academic Article
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Prion protein structural features indicate possible relations to signal peptidases Academic Article
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Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter Academic Article
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Probing the structural basis for enzyme-substrate recognition in Cu, Zn superoxide dismutase Academic Article
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Processing of the psbA 5' untranslated region in Chlamydomonas reinhardtii depends upon factors mediating ribosome association Academic Article
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Prodynorphin gene-expression relates to nf-kappa-b factors Academic Article
Profiling protein kinases and other ATP binding proteins in Arabidopsis using Acyl-ATP probes Academic Article
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Progress in the design of DNA sequence-specific lexitropsins Academic Article
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Promoter scanning for transcription inhibition with DNA-binding polyamides Academic Article
Promoter-targeted phage display selections with preassembled synthetic zinc finger libraries for endogenous gene regulation Academic Article
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Protein arginine deiminase 4: Evidence for a reverse protonation mechanism Academic Article
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Protein flexibility in virtual screening: the BACE-1 case study Academic Article
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Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype Academic Article
Proteomic profiling of metalloprotease activities with cocktails of active-site probes Academic Article
Proteomimetic libraries: Design, synthesis, and evaluation of p53-MDM2 interaction inhibitors Academic Article
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Proton magnetic resonance studies of human cyanomethemoglobin Academic Article
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Proton-transfer effects in the active-site region of Escherichia coli thioredoxin using two-dimensional (1)H NMR Academic Article
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Purification and immunological studies of glutathione reductase from rat liver. Evidence for an antigenic determinant at the nucleotide-binding domain of the enzyme Academic Article
Purification and properties of progesterone receptors from chick oviduct Academic Article
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Purification of human uterine progesterone receptor Academic Article
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif Academic Article
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Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP Academic Article
Quantitative fluorometric assay for detection and characterization of fc receptors Academic Article
Quantum chemical studies of intermediates and reaction pathways in selected enzymes and catalytic synthetic systems Academic Article
RNA recognition by designed peptide fusion creates "artificial" tRNA synthetase Academic Article
RNA target specificity of the STAR/GSG domain post-transcriptional regulatory protein GLD-1 Academic Article
RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint Academic Article
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Rad50/smc proteins and abc transporters: Unifying concepts from high-resolution structures Academic Article
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Rational design of a functional metalloenzyme: introduction of a site for manganese binding and oxidation into a heme peroxidase Academic Article
Rational design of potent human transthyretin amyloid disease inhibitors Academic Article
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Reaction mechanism of single subunit nadh-ubiquinone oxidoreductase (ndi1) from saccharomyces cerevisiae evidence for a ternary complex mechanism Academic Article
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Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide Academic Article
Reactive immunization Academic Article
Recent advances in developing small molecules targeting RNA Academic Article
Recent developments and applications of clickable photoprobes in medicinal chemistry and chemical biology Academic Article
Recent developments in the investigation of the paramagnetic centers in low-spin ferric hemoproteins: carbon-13 hyperfine shifts in iron porphyrin complexes Academic Article
Recent results on how aminoacyl transfer RNA synthetases recognize specific transfer RNAs Academic Article
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Receptor for motilin identified in the human gastrointestinal system Academic Article
Receptor for soluble c3 and c3b on human lymphoblastoid (raji) cells. Properties and biologocal significance Academic Article
Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus Academic Article
Recognition and sequestration of ω-fatty acids by a cavitand receptor Academic Article
Recognition elements for 5 ' exon substrate binding to the Candida albicans group I intron Academic Article
Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells Academic Article
Recognition of sequence-directed DNA structure by the klenow fragment of DNA polymerase i Academic Article
Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein Academic Article
Recognition of the mrna au-rich element by the zinc finger domain of tis11d Academic Article
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Recognition templates for predicting adenylate-binding sites in proteins Academic Article
Recovery of soluble sheep erythrocyte receptor from the T lymphocyte surface by proteolytic cleavage Academic Article
Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections Academic Article
Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation Academic Article
Redesigning enzyme topology by directed evolution Academic Article
Rediocides A and G as potential antitoxins against cobra venom Academic Article
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Refined crystallographic structure of pseudomonas aeruginosa exotoxin a and its implications for the molecular mechanism of toxicity Academic Article
Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution Academic Article
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Regulation of acetylcholine receptors on chick ciliary ganglion neurons by components from the synaptic target tissue Academic Article
Regulation of adenovirus membrane penetration by the cytoplasmic tail of integrin beta 5 Academic Article
Regulation of cell adhesion by PAI-1 Academic Article
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Regulation of gene expression by small molecules Academic Article
Regulation of human lymphocyte function by a soluble extract from normal human liver Academic Article
Regulation of the MEF2 family of transcription factors by p38 Academic Article
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Regulation of the human bilirubin UDP-glucuronosyltransferase gene Academic Article
Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation Academic Article
Regulation of von Willebrand factor binding to the platelet glycoprotein Ib-IX by a membrane skeleton-dependent inside-out signal Academic Article
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Relationship of the human-immunodeficiency-virus type-1 gp120 3rd variable loop to a component of the cd4 binding-site in the 4th conserved region Academic Article
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Relaxation spectra of the iron spin transition in methemoglobin Academic Article
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Requirement of helix 1 and the af-2 domain of the thyroid hormone receptor for coactivation by pgc-1 Academic Article
Residue met(156) contributes to the labile enzyme conformation of coagulation factor viia Academic Article
Residues in a class I tRNA synthetase which determine selectivity of amino acid recognition in the context of tRNA Academic Article
Resolution of site-specific conformational heterogeneity in proline-rich molecular recognition by Src homology 3 domains Academic Article
Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin a Academic Article
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Reversal of ADP-mediated aggregation of adenosine kinase by cyclophilin leads to its reactivation Academic Article
Reversible regulation of tissue factor-induced coagulation by glycosyl phosphatidylinositol-anchored tissue factor pathway inhibitor Academic Article
Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains Academic Article
Rhombohedral crystals of the human vinculin head domain in complex with a vinculin-binding site of talin Academic Article
Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding Academic Article
Ribosomal-RNA genes in nucleus and chloroplast of Euglena Academic Article
Ribosome assembly factors prevent premature translation initiation by 40S assembly intermediates Academic Article
Rigid body refinement of protein complexes with long-range distance restraints from pulsed dipolar ESR Academic Article
Role of DNA sequence in the binding specificity of synthetic basic-helix-loop-helix domains Academic Article
Role of RNA structure in arginine recognition of TAR RNA Academic Article
Role of Rab9 GTPase in facilitating receptor recruitment by TIP47 Academic Article
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome Academic Article
Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase Academic Article
Role of an active site adenine in hairpin ribozyme catalysis Academic Article
Role of an active site guanine in hairpin ribozyme catalysis probed by exogenous nucleobase rescue Academic Article
Role of aspartate-37 in determining cofactor specificity and binding in rat-liver dihydropteridine reductase Academic Article
Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization Academic Article
Role of cyclic nucleotides in central synaptic function Academic Article
Role of electrostatic interactions in PDZ domain ligand recognition Academic Article
Role of gtp hydrolysis in microtubule dynamics - information from a slowly hydrolyzable analog, gmpcpp Academic Article
Role of hydrogen bonding in the active site of human manganese superoxide dismutase Academic Article
Role of the glutamyl alpha-carboxylate of the substrate glutathione in the catalytic mechanism of human glutathione transferase A1-1 Academic Article
Role of third intracellular loop of galanin receptor type 1 in signal transduction Academic Article
Role of tryptophan 161 in catalysis by human manganese superoxide dismutase Academic Article
Role of zymogen and activated factor x as scaffolds for the inhibition of the blood coagulation factor viia-tissue factor complex by recombinant nematode anticoagulant protein c2 Academic Article
Roles of Dim2 in ribosome assembly Academic Article
Roles of IFN consensus sequence binding protein and PU.1 in regulating IL-18 gene expression Academic Article
Roles of bound quinone in the single subunit nadh-quinone oxidoreductase (ndi1) from saccharomyces cerevisiae Academic Article
Rotational correlation time of concanavalin-a after interaction with a fluorescent-probe Academic Article
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S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration Academic Article
S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death Academic Article
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SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation Academic Article
SR2067 reveals a unique kinetic and structural signature for PPARγ partial agonism Academic Article
SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent Academic Article
STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells Academic Article
SUMO-binding motifs mediate the Rad60-dependent response to replicative stress and self-association Academic Article
SV40 T antigen interacts with Nbs1 to disrupt DNA replication control Academic Article
Saccharomyces cerevisiae lme2 phosphorylates Sic1 at multiple PXS/T sites but is insufficient to trigger Sic1 degradation Academic Article
Salicylates are interference compounds in TR-FRET assays Academic Article
Screening a peptidyl database for potential ligands to proteins with side-chain flexibility Academic Article
Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay Academic Article
Screening transthyretin amyloid fibril inhibitors: Characterization of novel multiprotein, multiligand complexes by mass spectrometry Academic Article
Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2 Academic Article
Selecting against s1p(3) enhances the acute cardiovascular tolerability of 3-(n-benzyl)aminopropylphosphonic acid s1p receptor agonists Academic Article
Selection and application of peptide-binding peptides Academic Article
Selection by site-directed antibodies of small regions of peptides which are ordered in water Academic Article
Selection of apoptotic cell specific human antibodies from adult bone marrow Academic Article
Selection pressure on hiv-1 envelope by broadly neutralizing antibodies to the conserved cd4-binding site Academic Article
Selective attenuation of the extrinsic limb of the tissue factor-driven coagulation protease cascade by occupancy of a novel peptidyl docking site on tissue factor Academic Article
Selective binding-site for (prostacyclin-h-3 on platelets Academic Article
Selective chemical catalysis by an antibody Academic Article
Selective inhibition of ADAR2-catalyzed editing of the serotonin 2c receptor pre-mRNA by a helix-threading peptide Academic Article
Selective interaction of heparin with the variable region 3 within surface glycoprotein of laboratory-adapted feline immunodeficiency virus Academic Article
Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120 Academic Article
Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets Academic Article
Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for analysis of peptide hormone interactions with bovine neurophysin i using 13C nuclear magnetic-resonance spectroscopy Academic Article
Selectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuations Academic Article
Self-association of the histidine kinase CheA as studied by pulsed dipolar ESR spectroscopy Academic Article
Sendai virus utilizes specific sialyloligosaccharides as host-cell receptor determinants Academic Article
Sensitizer-linked substrates and ligands: Ruthenium probes of cytochrome P450 structure and mechanism Academic Article
Separate cell-binding sites within cytotactin tenascin differentially promote neurite outgrowth Academic Article
Sequence and structural convergence of broad and potent hiv antibodies that mimic cd4 binding Academic Article
Sequence homology and structural analysis of the clostridial neurotoxins Academic Article
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Sequence-specific NMR assignment of proteins by global fragment mapping with the program mapper Academic Article
Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides Academic Article
Sequence-specific resonance assignments in the h-1-NMR spectrum of the lac repressor DNA-binding domain 1-51 from escherichia-coli by two-dimensional spectroscopy Academic Article
Sequential action of MalE and maltose allows coupling ATP hydrolysis to translocation in the MalFGK(2) transporter Academic Article
Ser-884 adjacent to the lxxll motif of coactivator trbp defines selectivity for ers and trs Academic Article
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations Academic Article
Serine hydrolase KIAA1363: Toxicological and structural features with emphasis on organophosphate interactions Academic Article
Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport Academic Article
Seven clues to the origin and structure of class-I ribonucleotide reductase intermediate X Academic Article
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Shape complementarity of protein-protein complexes at multiple resolutions Academic Article
Shape-specific nucleotide binding of single-stranded RNA by the GLD-1 STAR domain Academic Article
Shigella applies molecular mimicry to subvert vinculin and invade host cells Academic Article
Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines Academic Article
Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells Academic Article
Side-chain conformational heterogeneity of intermediates in the Escherichia coli dihydrofolate reductase catalytic cycle Academic Article
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Significant structural and functional change of an antigen-binding site by a distant amino-acid substitution - proposal of a structural mechanism Academic Article
Simple method for production of specific xenoantisera to human histocompatibility (hla-a, hla-b, hla-c) antigens Academic Article
Simple reporter gene-based assays for hairpin poly(amide) conjugate permeability and DNA-binding activity in living cells Academic Article
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Single sequence of a helix-loop peptide confers functional anticodon recognition on two tRNA synthetases Academic Article
Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR Academic Article
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Site-directed mutagenesis of the complement c5a receptor - examination of a model for its interaction with the ligand c5a Academic Article
Site-directed mutagenesis of the human beta(3)-adrenoceptor - transmembrane residues involved in ligand binding and signal transduction Academic Article
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Solution structure of rnase p rna Academic Article
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Statistical positioning of nucleosomes by specific protein-binding to an upstream activating sequence in yeast Academic Article
Status of gpcr modeling and docking as reflected by community-wide gpcr dock 2010 assessment Academic Article
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Stimulation of nuclear export and inhibition of nuclear import by a ran mutant deficient in binding to ran-binding protein 1 Academic Article
Strained cyclic disulfides enable cellular uptake by reacting with the transferrin receptor Academic Article
Streptococcal m1 protein constructs a pathological host fibrinogen network Academic Article
Striated muscle activator of Rho signalling (STARS) is a PGC-1 alpha/oestrogen-related receptor-alpha target gene and is upregulated in human skeletal muscle after endurance exercise Academic Article
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling Academic Article
Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains Academic Article
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Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II Academic Article
Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6 Academic Article
Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome p4502b4 Academic Article
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Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair Academic Article
Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors Academic Article
Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor Academic Article
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Structural basis for bifunctional peptide recognition at human delta-opioid receptor Academic Article
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Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases Academic Article
Structural basis for endothelial nitric oxide synthase binding to calmodulin Academic Article
Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase Academic Article
Structural basis for hif-1 alpha/cbp recognition in the cellular hypoxic response Academic Article
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Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics Academic Article
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase Academic Article
Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway Academic Article
Structural basis for molecular recognition at serotonin receptors Academic Article
Structural basis for recognition and catalysis by the bifunctional dctp deaminase and dutpase from methanococcus jannaschii Academic Article
Structural basis for recruitment of cbp/p300 coactivators by stat1 and stat2 transactivation domains Academic Article
Structural basis for specific inhibition of tRNA synthetase by an ATP competitive inhibitor Academic Article
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase Academic Article
Structural basis for the coevolution of a viral RNA-protein complex Academic Article
Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases Academic Article
Structural basis for type-I and type-II deficiencies of antithrombotic plasma protein-C - patterns revealed by 3-dimensional molecular modeling of mutations of the protease domain Academic Article
Structural basis of IMP3 RRM12 recognition of RNA Academic Article
Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2 Academic Article
Structural basis of Rho GTPase-mediated activation of the formin rndia1 Academic Article
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Structural basis of autoregulation of phenylalanine hydroxylase Academic Article
Structural basis of cell surface receptor recognition by botulinum neurotoxin B Academic Article
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Structural basis of single-nucleotide polymorphisms in cytochrome P450 2C9 Academic Article
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Structural biology of the S1P1 receptor Academic Article
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Structural determinants in domain II of human glutathione transferase M2-2 govern the characteristic activities with aminochrome, 2-cyano-1,3-dimethyl-1-nitrosoguanidine, and 1,2-dichloro-4-nitrobenzene Academic Article
Structural determinants of binding the seven-transmembrane domain of the glucagon-like peptide-1 receptor (GLP-1R) Academic Article
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Structural identification of the antibody-binding sites of hong-kong influenza hemagglutinin and their involvement in antigenic variation Academic Article
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Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein Academic Article
Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B Academic Article
Structural insights into protein-metal ion partnerships Academic Article
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Structural insights into the evolution of an antibody combining site Academic Article
Structural insights into the function of the rab gdi superfamily Academic Article
Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor Academic Article
Structural insights into the mechanisms of mg2+ uptake, transport, and gating by cora Academic Article
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Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins Academic Article
Structural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103 Academic Article
Structural invariance of constitutively active and inactive mutants of acanthamoeba myosin ic bound to f-actin in the rigor and adp-bound states Academic Article
Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus Academic Article
Structural mechanism of abscisic acid binding and signaling by dimeric PYR1 Academic Article
Structural mimicry in the phage phi 21 N peptide-boxB RNA complex Academic Article
Structural model studies for the peroxo intermediate P and the reaction pathway from P -> Q of methane monooxygenase using broken-symmetry density functional calculations Academic Article
Structural organization of complexes of transfer RNAs with aminoacyl transfer RNA synthetases Academic Article
Structural plasticity and the evolution of antibody affinity and specificity Academic Article
Structural properties of non-traditional drug targets present new challenges for virtual screening Academic Article
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Structural role of a buried salt bridge in the 434 repressor DNA-binding domain Academic Article
Structural studies of FIV and HIV-1 proteases complexed with all efficient inhibitor of FIV protease Academic Article
Structural studies of atom-specific anticancer drugs acting on DNA Academic Article
Structural studies of cytochrome c-551 by h-1 NMR-spectroscopy at 360 mhz Academic Article
Structural studies of p21(waf1/cip1/sdi1) in the free and cdk2-bound state: Conformational disorder mediates binding diversity Academic Article
Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors Academic Article
Structural variations in species B adenovirus fibers impact CD46 association Academic Article
Structural-analysis of rauscher virus gp70 using monoclonal-antibodies - sites of antigenicity and p15(e) linkage Academic Article
Structural-based analysis of dihydrofolate reductase evolution Academic Article
Structure analysis of peptide deformylases from Streptococcus pneumoniae, Staphylococcus aureus, Thermotoga maritima and Pseudomonas aeruginosa: Snapshots of the oxygen sensitivity of peptide deformylase Academic Article
Structure and activity of a thermostable thymine-DNA glycosylase: Evidence for base twisting to remove mismatched normal DNA bases Academic Article
Structure and dynamics of the liver receptor homolog 1-PGC1α complex Academic Article
Structure and function of a genetically engineered mimic of a nonenveloped virus entry intermediate Academic Article
Structure and function of a novel LD-carboxypeptidase A involved in peptidoglycan recycling Academic Article
Structure and function of an unusual family of protein phosphatases: the bacterial chemotaxis proteins CheC and CheX Academic Article
Structure and function of helix-loop-helix proteins Academic Article
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Structure and function of the von Willebrand factor A1 domain Academic Article
Structure and function of von Willebrand factor: relationship to von Willebrand's disease Academic Article
Structure and functional characterization of the rna-binding element of the nlrx1 innate immune modulator Academic Article
Structure and functional role of dynein's microtubule-binding domain Academic Article
Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634 Academic Article
Structure and lytic activity of a bacillus anthracis prophage endolysin Academic Article
Structure and mechanism of copper, zinc superoxide-dismutase Academic Article
Structure and mechanism of the ruvb holliday junction branch migration motor Academic Article
Structure and mutational analysis of Rab GDP-dissociation inhibitor Academic Article
Structure and receptor specificity of the hemagglutinin from an h5n1 influenza virus Academic Article
Structure and thermodynamic characterization of the ephb4/ephrin-b2 antagonist peptide complex reveals the determinants for receptor specificity Academic Article
Structure at 0.85 Å resolution of an early protein photocycle intermediate Academic Article
Structure based prediction of subtype-selectivity for adenosine receptor antagonists Academic Article
Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes Academic Article
Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 A resolution: The first structural representative of a new protein family that may play a role in carbohydrate metabolism Academic Article
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding Academic Article
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Academic Article
Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase Academic Article
Structure of Thermotoga maritima TM0439: Implications for the mechanism of bacterial GntR transcription regulators with Zn(2+)-binding FCD domains Academic Article
Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion Academic Article
Structure of a cation-bound multidrug and toxic compound extrusion transporter Academic Article
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator Academic Article
Structure of a dicationic monoimidazole lexitropsin bound to DNA Academic Article
Structure of a kinesin microtubule depolymerization machine Academic Article
Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site Academic Article
Structure of a nitric oxide synthase heme protein from Bacillus subtilis Academic Article
Structure of a protein photocycle intermediate by millisecond time-resolved crystallography Academic Article
Structure of a thioredoxin-like 2fe-2s ferredoxin from aquifex aeolicus Academic Article
Structure of a trimeric nucleoporin complex reveals alternate oligomerization states Academic Article
Structure of a v3-containing hiv-1 gp120 core Academic Article
Structure of activated aconitase - formation of the 4fe-4s cluster in the crystal Academic Article
Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation Academic Article
Structure of an agonist-bound human A₂A adenosine receptor Academic Article
Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases Academic Article
Structure of avian aicar transformylase with a multisubstrate adduct inhibitor β-DADF identifies the folate binding site Academic Article
Structure of azotobacter vinelandii 7fe ferredoxin at 1.35 Å resolution and determination of the fe-s bonds with 0.01 Å accuracy Academic Article
Structure of botulinurn neurotoxin type d light chain at 1.65 Å resolution: Repercussions for vamp-2 substrate specificity Academic Article
Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5a resolution using amino-acid sequence data Academic Article
Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway Academic Article
Structure of hiv-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility Academic Article
Structure of human cyclophilin and its binding-site for cyclosporine-a determined by x-ray crystallography and NMR-spectroscopy Academic Article
Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site Academic Article
Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding Academic Article
Structure of mammalian poly(adp- ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element Academic Article
Structure of microsomal cytochrome p4502b4 complexed with the antifungal drug bifonazole - insight into p450 conformational plasticity and membrane interaction Academic Article
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate Academic Article
Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab Academic Article
Structure of the CAD domain of caspase-activated DNase and interaction with the CAD domain of its inhibitor Academic Article
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex Academic Article
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone Academic Article
Structure of the DNA repair and replication endonuclease and exonuclease fen-1: Coupling DNA and pcna binding to fen-1 activity Academic Article
Structure of the DNA repair enzyme endonuclease iv and its DNA complex: Double-nucleotide flipping at abasic sites and three-metal-ion catalysis Academic Article
Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation Academic Article
Structure of the I-1 early intermediate of photoactive yellow protein by FTIR spectroscopy Academic Article
Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding Academic Article
Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain Academic Article
Structure of the actin-myosin complex and its implications for muscle-contraction Academic Article
Structure of the hemagglutinin membrane glycoprotein of influenza-virus at 3-a resolution Academic Article
Structure of the heterodimeric complex between CAD domains of CAD and ICAD Academic Article
Structure of the human ATG12 similar to ATG5 conjugate required for LC3 lipidation in autophagy Academic Article
Structure of the human Dicer-TRBP complex by electron microscopy Academic Article
Structure of the human P2Y(12) receptor in complex with an antithrombotic drug Academic Article
Structure of the human TRPM4 ion channel in a lipid nanodisc Academic Article
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist Academic Article
Structure of the human epithelial sodium channel by cryo-electron microscopy Academic Article
Structure of the human glucagon class B G-protein-coupled receptor Academic Article
Structure of the human histamine h(1) receptor complex with doxepin Academic Article
Structure of the human smoothened receptor bound to an antitumour agent Academic Article
Structure of the human κ-opioid receptor in complex with JDTic Academic Article
Structure of the influenza-virus hemagglutinin complexed with its receptor, sialic-acid Academic Article
Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity Academic Article
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic Academic Article
Structure of the nuclear factor aly: Insights into post-transcriptional regulatory and mrna nuclear export processes Academic Article
Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of creb binding protein Academic Article
Structure of the uncleaved human h1 hemagglutinin from the extinct 1918 influenza virus Academic Article
Structure of the von Willebrand factor domain interacting with glycoprotein Ib Academic Article
Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction Academic Article
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase Academic Article
Structure of transfer RNA-aminoacyl transfer RNA synthetase complexes investigated by nuclease digestion Academic Article
Structure of yeast RNA polymerase II in solution: Implications for enzyme regulation and interaction with promoter DNA Academic Article
Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D28K Academic Article
Structure, redox, pKa, spin. A golden tetrad for understanding metalloenzyme energetics and reaction pathways Academic Article
Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105 Academic Article
Structure-activity relationships in a peptidic alpha 7 nicotinic acetylcholine receptor antagonist Academic Article
Structure-activity relationships in flexible protein domains: Regulation of Rho GTPases by RhoGDI and D4 GDI Academic Article
Structure-activity relationships in the binding of chemically derivatized cd4 to gp120 from human immunodeficiency virus Academic Article
Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases Academic Article
Structure-based active site profiles for genome analysis and functional family subclassification Academic Article
Structure-based analysis of Bacilli and plasmid dihydrofolate reductase evolution Academic Article
Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids Academic Article
Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase Academic Article
Structure-based discovery of cellular-active allosteric inhibitors of FAK Academic Article
Structure-based engineering of internal cavities in coiled-coil peptides Academic Article
Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors Academic Article
Structure-based mutagenesis approaches toward expanding the substrate specificity of d-2-deoxyribose-5-phosphate aldolase Academic Article
Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine Academic Article
Structure-based stabilization of hiv-1 gp120 enhances humoral immune responses to the induced co-receptor binding site Academic Article
Structure-based, targeted deglycosylation of hiv-1 gp120 and effects on neutralization sensitivity and antibody recognition Academic Article
Structure-function relationship of proteins belonging to the family of receptors coupled to gtp-binding proteins Academic Article
Structure-function relationships of platelet glycoprotein Ib as a receptor for von Willebrand factor Academic Article
Structure-guided inhibitor design for human FAAH by interspecies active site conversion Academic Article
Structure/function studies on a S-adenosyl-(L)-methionine-dependent uroporphyrinogen III C methyltransferase (SUMT), a key regulatory enzyme of tetrapyrrole biosynthesis Academic Article
Structures of EF-hand Ca2+-binding proteins: diversity in the organization, packing and response to Ca2+ binding Academic Article
Structures of clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility Academic Article
Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition Academic Article
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457 Academic Article
Structures of the N-omega-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins Academic Article
Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: Heme activation via reduction-gated exogenous ligand exchange Academic Article
Studies of bovine neurophysin-neurohypophyseal hormone interactions Academic Article
Studies of histidine residues of triose phosphate isomerase by proton magnetic-resonance and x-ray crystallography Academic Article
Studies of reactions of substituted d,l-erythro-beta-phenylserines with lamb liver serine hydroxymethylase - effects of substituents upon de-aldolization step Academic Article
Studies on reconstitution of bovine erythrocyte superoxide dismutase .1. Presence of four divalent metal-binding sites on apo protein which are different from native sites Academic Article
Studies on reconstitution of bovine erythrocyte superoxide dismutase .3. Evidence for a strong interdependence between cu2+ and zn2+ binding in expression of spectroscopic properties of native protein and for a close proximity of zn2+ and cu2+ sites Academic Article
Studies on reconstitution of bovine erythrocyte superoxide dismutase .4. Preparation and some properties of enzyme in which co(ii) is substituted for zn(ii) Academic Article
Studies on reconstitution of bovine erythrocyte superoxide-dismutase .5. Preparation and properties of derivatives in which both zinc and copper sites contain copper Academic Article
Studies on the mechanism of enzymatic DNA elongation by Escherichia coli DNA polymerase II Academic Article
Studies on the structure of nadh-ubiquinone oxidoreductase complex - topography of the subunits of the iron-sulfur flavoprotein component Academic Article
Study of redox reactions of biological importance between fe(iii) complexes and aromatic moieties Academic Article
Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP Academic Article
Subdomain chimeras of hepatic lipase and lipoprotein lipase - localization of heparin and cofactor binding Academic Article
Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065 Academic Article
Substituting c-jun n-terminal kinase-3 (jnk3) atp-binding site amino acid residues with their p38 counterparts affects binding of jnk- and p38-selective inhibitors Academic Article
Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes Academic Article
Substrate recognition and catalysis by flap endonucleases and related enzymes Academic Article
Substrate recognition, protein dynamics, and iron-sulfur cluster in Pseudomonas aeruginosa adenosine 5'-phosphosulfate reductase Academic Article
Substrate specificities of two tau class glutathione transferases inducible by 2,4,6-trinitrotoluene in poplar Academic Article
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ Academic Article
Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase Academic Article
Subtle atomic group discrimination in the RNA minor groove Academic Article
Subunit composition and domain-structure of the spo0a sporulation transcription factor of bacillus-subtilis Academic Article
Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors Academic Article
Sulfatases: Structure, mechanism, biological activity, inhibition, and synthetic utility Academic Article
Sulfated blood-group lewis(a) - a superior oligosaccharide ligand for human e-selectin Academic Article
Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor Academic Article
Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin Academic Article
Sulfite reductase structure at 1.6 Å - evolution and catalysis for reduction of inorganic anions Academic Article
Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90 Academic Article
Superoxide-dismutase - examination of the metal-binding sites by electron-spin echo spectroscopy Academic Article
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130 Academic Article
Surface markers on human b-lymphocytes and t-lymphocytes .9. 2-color immunofluorescence studies on association between ebv receptors and complement receptors on surface of lymphoid-cell lines Academic Article
Symmetrical stabilization of bound Ca2+ ions in a cooperative pair of EF-hands through hydrogen bonding of coordinating water molecules in calbindin D-9k Academic Article
Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1 Academic Article
Synergistic activation of transcription by physiologically unrelated transcription factors through cooperative DNA-binding Academic Article
Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast Academic Article
Synergy of NMR, computation, and x-ray crystallography for structural biology Academic Article
Synergy of silent and hot spot mutations in importin beta reveals a dynamic mechanism for recognition of a nuclear localization signal Academic Article
Synthesis and activity of new aryl- and heteroaryl- substituted pyrazole inhibitors of the transforming growth factor-βtype I receptor kinase domain Academic Article
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors Academic Article
Synthesis and applications of a deep, asymmetric cavitand on a solid support Academic Article
Synthesis and biological activity of a bivalent nucleotide inhibitor of ribonucleotide reductase Academic Article
Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R) Academic Article
Synthesis and evaluation of 1-(substituted)-3-prop-2-ynylureas as antiangiogenic agents Academic Article
Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors Academic Article
Synthesis and evaluation of deglycobleomycin A(2) analogues containing a tertiary N-methyl amide and simple ester replacement for the L-histidine secondary amide: Direct functional characterization of the requirement for secondary amide metal complexation Academic Article
Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenyl sulfate and cyclic phenyl sulfamate motifs Academic Article
Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid Academic Article
Synthesis and evaluation of potential N-pi and N-sigma metal chelation sites within the beta-hydroxy-L-histidine subunit of bleomycin A(2): Functional characterization of imidazole N-pi metal complexation Academic Article
Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase Academic Article
Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA Academic Article
Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid Academic Article
Synthesis of key analogs of bleomycin A(2) that permit a systematic evaluation of the linker region - identification of an exceptionally prominent role for the L-threonine substituent Academic Article
Synthesis of key sandramycin analogs: Systematic examination of the intercalation chromophore Academic Article
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Synthesis of oligomeric mannosides and their structure-binding relationship with concanavalin A Academic Article
Synthesis of potent bicyclic bisarylimidazole c-jun N-terminal kinase inhibitors by catalytic C-H bond activation Academic Article
Synthesis of programmable integrases Academic Article
Synthesis of sesquiterpene-inspired derivatives designed for covalent binding and their inhibition of the NF-κB pathway Academic Article
Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers Academic Article
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents Academic Article
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Synthetic seleno-glutaredoxin 3 analogues are highly reducing oxidoreductases with enhanced catalytic efficiency Academic Article
T-antigen binds to simian virus-40 DNA at origin of replication Academic Article
T-cell antigen receptor-binding sites for the microbial superantigen staphylococcal enterotoxin-a Academic Article
T-cell receptor beta-chain binding to enterotoxin superantigens Academic Article
T-cell receptor structure and tcr complexes Academic Article
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Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders Academic Article
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities Academic Article
Targeted isolation of antibodies directed against major sites of SIV Env vulnerability Academic Article
Targeting a pneumocystis carinii group i intron with methylphosphonate oligonucleotides: Backbone charge is not required for binding or reactivity Academic Article
Targeting of t lymphocytes to melanoma cells through chimeric anti-gd3 immunoglobulin t-cell receptors Academic Article
Targeting renal cell carcinoma with a HIF-2 antagonist Academic Article
Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening Academic Article
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The 0.78 Å structure of a serine protease: Bacillus lentus subtilisin Academic Article
The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site Academic Article
The 150-loop restricts the host specificity of human H10N8 influenza virus Academic Article
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist Academic Article
The 2002 Bernard B. Brodie Award Lecture: Deciphering substrate recognition by drug-metabolizing cytochromes P450 Academic Article
The 3.2 A resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays Academic Article
The 5S gene internal control region is B-form both free in solution and in a complex with TFIIIA Academic Article
The C2A domain of JFC1 binds to 3 '-phosphorylated phosphoinositides and directs plasma membrane association in living cells Academic Article
The Caenorhabditis elegans unc-13 gene product is a phospholipid-dependent high-affinity phorbol ester receptor Academic Article
The DNA repair endonuclease xpg interacts directly and functionally with the wrn helicase defective in werner syndrome Academic Article
The EF-hand domain: a globally cooperative structural unit Academic Article
The LG3 module of laminin-5 harbors a binding site for integrin α3β1 that promotes cell adhesion, spreading, and migration Academic Article
The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments Academic Article
The N-terminal nuclear localization sequences of liver X receptors α and β bind to importin α and are essential for both nuclear import and transactivating functions Academic Article
The ND1 subunit constructs the inhibitor binding domain in bovine heart mitochondrial complex I Academic Article
The NMR structure of cyclosporine-a bound to cyclophilin in aqueous-solution Academic Article
The NMR structure of the activation domain isolated from porcine procarboxypeptidase-b Academic Article
The NS5A protein of bovine viral diarrhea virus contains an essential zinc-binding site similar to that of the hepatitis C virus NS5A protein Academic Article
The NS5A protein of hepatitis C virus is a zinc metalloprotein Academic Article
The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit Academic Article
The PAI-1/vitronectin interaction: two cats in a bag? Academic Article
The RCSB Protein Data Bank: views of structural biology for basic and applied research and education Academic Article
The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2 Academic Article
The VEGF IRESes are differentially susceptible to translation inhibition by miR-16 Academic Article
The X-ray crystal structure of the human mono-oxygenase cytochrome P450 3A5-ritonavir complex reveals active site differences between P450s 3A4 and 3A5 Academic Article
The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways Academic Article
The action of cardiolipin on the bacterial translocon Academic Article
The active site of staphylococcal nuclease: paramagnetic relaxation of bound nucleotide inhibitor nuclei by lanthanide ions Academic Article
The active-site residue Tyr-175 in human glyoxalase II contributes to binding of glutathione derivatives Academic Article
The amino-terminus of the human c5a receptor is required for high-affinity c5a binding and for receptor activation by c5a but not c5a analogs Academic Article
The antibody problem Academic Article
The antitumor agent cc-1065 inhibits helicase-catalyzed unwinding of duplex DNA Academic Article
The anxiolytic-like effects of the neurosteroid allopregnanolone: Interactions with gaba(a) receptors Academic Article
The artt motif and a unified structural understanding of substrate recognition in adp-ribosylating bacterial toxins and eukaryotic adp-ribosyltransferases Academic Article
The assignment of an exchangeable low-field NH proton resonance of ribonuclease A to the active-site histidine-119 Academic Article
The association of the c7 allotype of rabbits with some light polypeptide chains which lack b locus allotypy Academic Article
The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites Academic Article
The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50 Academic Article
The beta-2-adrenergic receptors of human epidermoid carcinoma-cells bear 2 different types of oligosaccharides which influence expression on the cell-surface Academic Article
The binding of substrates and a product of the enzymatic reaction to glutathione S-transferase A Academic Article
The biologic activity of the immunoregulatory lipoprotein, ldl-in, is independent of its free fatty-acid content Academic Article
The c-terminal domain of yeast pcna is required for physical and functional interactions with cdc9 DNA ligase Academic Article
The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition Academic Article
The catalytic site of cytochrome P4504A11 (CYP4A11) and its L131F mutant Academic Article
The cell-binding domains of plasminogen and their function in plasma Academic Article
The chemistry of the antibody molecule Academic Article
The client protein p53 adopts a molten globule-like state in the presence of hsp90 Academic Article
The conserved KMN network constitutes the core microtubule-binding site of the kinetochore Academic Article
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation Academic Article
The cooh terminus of aminoglycoside phosphotransferase (3 ')-iiia is critical for antibiotic recognition and resistance Academic Article
The core meiotic transcriptome in budding yeasts Academic Article
The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase Academic Article
The covalent and three-dimensional structure of concanavalin a Academic Article
The covalent structure of a human gamma G-immunoglobulin. XI. Functional implications Academic Article
The croonian lecture 2000. Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission Academic Article
The crystal structure of a novel bacterial adenylyltransferase reveals half of sites reactivity Academic Article
The crystal structure of avian cd1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian cd1 Academic Article
The crystal structure of human Argonaute2 Academic Article
The crystal structure of the Helicobacter pylori LlaJI.R1 N-terminal domain provides a model for site-specific DNA binding Academic Article
The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function Academic Article
The crystal structure of the human DNA repair endonuclease hap1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites Academic Article
The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity Academic Article
The crystal structures of chloramphenicol phosphotransferase reveal a novel inactivation mechanism Academic Article
The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism Academic Article
The cytoplasmic tall peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein Academic Article
The delta subunit of AP-3 is required for efficient transport of VSV-G from the trans-Golgi network to the cell surface Academic Article
The design and synthesis of novel alpha-ketoamide-based p38 map kinase inhibitors Academic Article
The dynamic energy landscape of dihydrofolate reductase catalysis Academic Article
The effect of ribosome assembly cofactors on in vitro 30S subunit reconstitution Academic Article
The evi-1 zinc-finger myeloid transforming protein binds to genomic fragments containing (gata)(n) sequences Academic Article
The evolution of cefotaximase activity in the TEM β-lactamase Academic Article
The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro Academic Article
The gal4 activation domain binds sug2 protein, a proteasome component, in vivo and in vitro Academic Article
The geminivirus nuclear shuttle protein is a virulence factor that suppresses transmembrane receptor kinase activity Academic Article
The gene of chicken axonin-1. Complete structure and analysis of the promoter Academic Article
The generation of stable cho-cell lines expressing very high-levels of complement c5a receptors and subsequent modulation of binding-affinity for c5a Academic Article
The growth-promoting activity of the bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3 Academic Article
The high activity of rat glutathione transferase 8-8 with alkene substrates is dependent on a glycine residue in the active site Academic Article
The high resolution crystal structure of green abalone sperm lysin: Implications for species-specific binding of the egg receptor Academic Article
The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme Academic Article
The homeobox transcription factor Barx2 regulates chondrogenesis during limb development Academic Article
The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells Academic Article
The human retinoblastoma susceptibility gene promoter is positively autoregulated by its own product Academic Article
The identification of metal-binding ligand residues in metalloproteins using nuclear magnetic resonance spectroscopy Academic Article
The immunological evolution of catalysis Academic Article
The importance of ligand-receptor conformational pairs in stabilization: spotlight on the N/OFQ G protein-coupled receptor Academic Article
The importance of thiol- and disulfide groups in agonist and antagonist binding to the muscarinic receptor Academic Article
The infectivity and host range of the ecotropic porcine endogenous retrovirus, perv-c, is modulated by residues in the c-terminal region of its surface envelope protein Academic Article
The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin Academic Article
The internal ribosome entry site (ires) contained within the rna-binding motif protein 3 (rbm3) mrna is composed of functionally distinct elements Academic Article
The kinetics of nucleated polymerizations at high concentrations: Amyloid fibril formation near and above the "supercritical concentration'' Academic Article
The kringle V-protease domain is a fibrinogen binding region within apo(a) Academic Article
The lef-1 high-mobility group domain undergoes a disorder-to-order transition upon formation of a complex with cognate DNA Academic Article
The leu-enkephalin-encoding sequence DNA-binding factor (lef) is the transcription factor yy1 Academic Article
The leukocyte cell-surface receptor(s) for the ic3b product of complement Academic Article
The maize (Zea mays L.) nucleoside diphosphate kinase1 (ZmNDPK1) gene encodes a human NM23-H2 homologue that binds and stabilizes G-quadruplex DNA Academic Article
The major nuclear envelope targeting domain of lap2 coincides with its lamin binding region but is distinct from its chromatin interaction domain Academic Article
The making of a phage Academic Article
The modular character of a DNA junction-resolving enzyme - a zinc-binding motif in bacteriophage-T4 endonuclease-VII Academic Article
The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins Academic Article
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule Academic Article
The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K Academic Article
The molecular perspective: Methotrexate Academic Article
The nadh-binding subunit of the energy-transducing nadh-ubiquinone oxidoreductase of paracoccus-denitrificans - gene cloning and deduced primary structure Academic Article
The nature of the enzymatic reduction of the mixed disulfide of coenzyme A and glutathione Academic Article
The nh2-terminal region of apolipoprotein b is sufficient for lipoprotein association with glycosaminoglycans Academic Article
The nuclear-magnetic-resonance solution structure of the mixed disulfide between escherichia-coli glutaredoxin(c14s) and glutathione Academic Article
The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathway Academic Article
The oncogenic potential of the high mobility group box protein sox3 Academic Article
The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger Academic Article
The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs Academic Article
The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster Academic Article
The proton-translocating nadh-quinone oxidoreductase (ndh-1) of thermophilic bacterium thermus thermophilus hb-8 - complete DNA sequence of the gene cluster and thermostable properties of the expressed nq02 subunit Academic Article
The rad50 signature motif: Essential to atp binding and biological function Academic Article
The rad50 zinc-hook is a structure joining mre11 complexes in DNA recombination and repair Academic Article
The recognition of H-2 and viral antigens by cytotoxic T cells Academic Article
The reduced, denatured somatomedin B domain of vitronectin refolds into a stable, biologically active molecule Academic Article
The regulatory regions of the rice tungro bacilliform virus promoter and interacting nuclear factors in rice (Oryza sativa L.) Academic Article
The relationship between structure and function for the sulfite reductases Academic Article
The retinoblastoma susceptibility gene-product represses transcription when directly bound to the promoter Academic Article
The rice phytochrome gene: structure, autoregulated expression, and binding of GT-1 to a conserved site in the 5' upstream region Academic Article
The role of arginine-143 in the electrostatics and mechanism of Cu,Zn superoxide-dismutase - computational and experimental evaluation by mutational analysis Academic Article
The role of dynamic conformational ensembles in biomolecular recognition Academic Article
The roles of S1 RNA-binding domains in Rrp5's interactions with pre-rRNA Academic Article
The second receptor binding site of the globular head of the newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion Academic Article
The self-inhibited structure of full-length PCSK9 at 1.9 Å reveals structural homology with resistin within the C-terminal domain Academic Article
The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope Academic Article
The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle Academic Article
The sialyltransferase sialylmotif participates in binding the donor substrate cmp-neuac Academic Article
The sigma(1) (sigma(1)) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming Academic Article
The small nuclear ribonucleoprotein SS-B/La binds RNA with a conserved protease-resistant domain of 28 kilodaltons Academic Article
The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML Academic Article
The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor Academic Article
The structural basis for biphasic kinetics in the folding of the WW domain from a formin-binding protein: lessons for protein design? Academic Article
The structural basis for in situ activation of DNA alkylation by duocarmycin sa Academic Article
The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae Academic Article
The structural basis of recognition and removal of cellular mrna 7-methyl g 'caps' by a viral capsid protein: A unique viral response to host defense Academic Article
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability Academic Article
The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type iiptrases Academic Article
The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0 Å resolution Academic Article
The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05 Å resolution Academic Article
The structure of jnk3 in complex with small molecule inhibitors: Structural basis for potency and selectivity Academic Article
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes Academic Article
The structure of the crispr-associated protein csa3 provides insight into the regulation of the crispr/cas system Academic Article
The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex Academic Article
The structure of the yeast nadh dehydrogenase (ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates Academic Article
The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif Academic Article
The tau-4 activation domain of the thyroid-hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing Academic Article
The theoretical limits of DNA sequence discrimination by linked polyamides Academic Article
The thermotoga maritima trk potassium transporter-from frameshift to function Academic Article
The third Trp-Lys-Ser (WKS) tripeptide motif in tissue factor is associated with a function site Academic Article
The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli Academic Article
The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis Academic Article
The transcriptional control of the perforin locus Academic Article
The transition-state regulator hpr of bacillus-subtilis is a DNA-binding protein Academic Article
The transition-state transcription regulator abrb of bacillus-subtilis is a DNA-binding protein Academic Article
The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire Academic Article
The usher syndrome proteins cadherin 23 and harmonin form a complex by means of pdz-domain interactions Academic Article
The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin Academic Article
The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments Academic Article
The way things move: Looking under the hood of molecular motor proteins Academic Article
Thermodynamic analysis of purified human placental alpha-l-fucosidase Academic Article
Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase Academic Article
Thermodynamics of RNA-RNA duplexes with 2-or 4-thiouridines: implications for antisense design and targeting a group I intron Academic Article
Thiol ligation of two zinc atoms to a class I tRNA synthetase: evidence for unshared thiols and role in amino acid binding and utilization Academic Article
Thioredoxin catalyzes the s-nitrosation of the caspase-3 active site cysteine Academic Article
Three pairs of cysteine residues mediate both redox and Zn2+ modulation of the NMDA receptor Academic Article
Three photo-cross-linked complexes of yeast phenylalanine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases Academic Article
Three-dimensional EM structure of the ectodomain of integrin alpha V beta 3 in a complex with fibronectin Academic Article
Three-dimensional location of the main immunogenic region of the acetylcholine receptor Academic Article
Three-dimensional model of membrane-bound ribosomes obtained by electron microscopy Academic Article
Three-dimensional model of the human platelet integrin alpha(llb)beta(3) based on electron cryomicroscopy and x-ray crystallography Academic Article
Three-dimensional solution structure of a single zinc finger DNA-binding domain Academic Article
Three-dimensional solution structure of the reduced form of Escherichia coli thioredoxin determined by nuclear magnetic resonance spectroscopy Academic Article
Three-dimensional structure of brush border myosin-i at similar to 20 Å resolution by electron microscopy and image analysis Academic Article
Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Academic Article
Tissue factor - molecular recognition and cofactor function Academic Article
Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity Academic Article
Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta(3) subunit Academic Article
Topography of the high-affinity lysine binding site of plasminogen as defined with a specific antibody probe Academic Article
Total syntheses and initial evaluation of [?[C(-S)NH]Tpg(4)]vancomycin, [?[C(-NH)NH]Tpg(4)]vancomycin, [?[CH2NH]Tpg(4)]vancomycin, and their (4-Chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptide antibiotics Academic Article
Total synthesis of Psi C(=NH)NH Tpg(4) vancomycin and its ((4)-chlorobiphenyl)methyl derivative: impact of peripheral modifications on vancomycin analogues redesigned for dual D-Ala-D-Ala and D-Ala-D-Lac binding Academic Article
Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5 '-gnn-3 ' DNA target sequences Academic Article
Toward understanding the structural basis of partial agonism at the dopamine D-3 receptor Academic Article
Transcript leader regions of two saccharomyces cerevisiae mrnas contain internal ribosome entry sites that function in living cells Academic Article
Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)to-DJ(H) rearrangement of immunoglobulin genes Academic Article
Transcription inactivation through local refolding of the RNA polymerase structure Academic Article
Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9 Academic Article
Transcriptional regulation of BCL-2 by nuclear factor kappa B and its significance in prostate cancer Academic Article
Transcriptional regulation of the mouse fatty acid amide hydrolase gene Academic Article
Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis Academic Article
Transfer RNA: from minihelix to genetic code Academic Article
Transfer of flexibility between ankyrin repeats in i kappa b alpha upon formation of the nf-kappa b complex Academic Article
Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase Academic Article
Trapping and characterization of novel retinoid response elements Academic Article
Trapping the dynamic acyl carrier protein in fatty acid biosynthesis Academic Article
Trial for peptide bond formation using model molecules based on the interactions between the CCA sequence of tRNA and 23S rRNA Academic Article
Tropomodulin binds to filensin intermediate filaments Academic Article
Tropomodulin contains two actin filament pointed end-capping domains Academic Article
Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin Academic Article
Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein Academic Article
Two classes of binding sites for uncoating protein in clathrin triskelions Academic Article
Two classes of cholesterol binding sites for the β2AR revealed by thermostability and NMR Academic Article
Two classes of tRNA synthetases suggested by sterically compatible dockings on tRNA acceptor stem Academic Article
Two estrogen receptors in reproductive tissue Academic Article
Two ligands may bind simultaneously to the muscarine receptor Academic Article
Two mutations in the promoter region of the human protein-C gene both cause type-I protein-C deficiency by disruption of 2 HNF-3 binding-sites Academic Article
Two photo-cross-linked complexes of isoleucine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases Academic Article
Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa Academic Article
Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides Academic Article
Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines Academic Article
Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors Academic Article
Type-III omega-agatoxins - a family of probes for similar binding-sites on L-type and N-type calcium channels Academic Article
Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2 '-deoxyuridine 5 '-monophosphate Academic Article
Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120 Academic Article
Uba domains mediate protein-protein interactions between two DNA damage-inducible proteins Academic Article
Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2 Academic Article
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates Academic Article
Ubiquitylation of cyclin e requires the sequential function of scf complexes containing distinct hcdc4 isoforms Academic Article
Understanding the enzymatic activity of 4-oxalocrotonate tautomerase and its mutant analogues: A computational study Academic Article
Understanding the recognition of transfer RNAs by aminoacyl transfer RNA synthetases Academic Article
Unexpected acetylcholinesterase activity of cocaine esterases Academic Article
Unexpected ca2+-binding properties of synaptotagmin 9 Academic Article
Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase Academic Article
Unique interactions of asialo von Willebrand factor with platelets in platelet-type von Willebrand disease Academic Article
Unmasking of CD22 co-receptor on germinal center B-cells occurs by alternative mechanisms in mouse and man Academic Article
Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease iv Academic Article
Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein lb Academic Article
Upstream activation sequence-dependent alteration of chromatin structure and transcription activation of the yeast GAL1-GAL10 genes Academic Article
Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects Academic Article
Use of phage display and transition-state analogs to select enzyme variants with altered catalytic properties: Glutathione transferase as an example Academic Article
Use of sialic-acid analogs to define functional-groups involved in binding to the influenza-virus hemagglutinin Academic Article
Using AutoDock for ligand-receptor docking Academic Article
Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task Academic Article
Using the process of reactive immunization to induce catalytic antibodies with complex mechanisms: Aldolases Academic Article
Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: Murine alpha 8 beta 1 binds to the rgd site in tenascin-c fragments, but not to native tenascin-c Academic Article
V-jun encodes a nuclear protein with enhancer binding properties of ap-1 Academic Article
Vaccine elicitation of high mannose-dependent neutralizing antibodies against the V3-glycan broadly neutralizing epitope in nonhuman primates Academic Article
Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign Academic Article
Vaccine-elicited tier 2 HIV-1 neutralizing antibodies bind to quaternary epitopes involving glycan-deficient patches proximal to the CD4 binding site Academic Article
Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention Academic Article
Variable loop glycan dependency of the broad and potent hiv-1-neutralizing antibodies pg9 and pg16 Academic Article
Variation and control of specific antigen-binding cell-populations in individual fetal mice Academic Article
Vinculin binding in its closed conformation by a helix addition mechanism Academic Article
Virtual screening against acetylcholine binding protein Academic Article
Virtual screening against alpha-cobratoxin Academic Article
Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors Academic Article
Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challenge Academic Article
Virus yoga: The role of flexibility in virus host cell recognition Academic Article
Virus-induced immune complex disease: specific anti-viral antibody and C1q binding material in the circulation during persistent lymphocytic choriomeningitis virus infection Academic Article
Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide Academic Article
Voronoi binding site model of a polycyclic aromatic hydrocarbon binding protein Academic Article
Water-soluble, recombinant cu-a-domain of the cytochrome ba(3) subunit ii from thermus thermophilus Academic Article
What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands? Academic Article
White matter NMDA receptors: an unexpected new therapeutic target? Academic Article
Wrn exonuclease structure and molecular mechanism imply an editing role in DNA end processing Academic Article
X-pro peptide-bond as an NMR probe for conformational studies of flexible linear peptides Academic Article
X-ray absorption studies of the Zn2+ site of glyoxalase I Academic Article
X-ray absorption studies of the copper-beta domain of rat-liver metallothionein Academic Article
X-ray crystallographic determination of the structure of the influenza c virus haemagglutinin-esterase-fusion glycoprotein Academic Article
X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus Academic Article
X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease Academic Article
X-ray structure of junctional adhesion molecule: Structural basis for homophilic adhesion via a novel dimerization motif Academic Article
X-ray structure of metallothionein Academic Article
X-ray structures of the LXRα LBD in its homodimeric form and implications for heterodimer signaling Academic Article
Xyloglucan sidechains modulate binding to cellulose during in vitro binding assays as predicted by conformational dynamics simulations Academic Article
Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway Academic Article
Yeast glyoxalase I is a monomeric enzyme with two active sites Academic Article
Yy1 binding to a subset of p53 DNA-target sites regulates p53-dependent transcription Academic Article
ZiF-Predict: a web tool for predicting DNA-binding specificity in C2H2 zinc finger proteins Academic Article
Zinc finger tools: Custom DNA-binding domains for transcription factors and nucleases Academic Article
Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology Academic Article
Zinc-dependent cell growth conferred by mutant tRNA synthetase Academic Article
Zinc-dependent tRNA binding by a peptide element within a tRNA synthetase Academic Article
Zinc-free and reduced t4 gene-32 protein binds single-stranded-DNA weakly and fails to stimulate uvsx-catalyzed homologous pairing Academic Article
Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB Academic Article
hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene Academic Article
p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses Academic Article
von Willebrand factor has more than one binding site for platelets Academic Article
von Willebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism Academic Article
γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin Academic Article

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