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  • 1.35 and 2.07 a resolution structures of the red abalone sperm lysin monomer and dimer reveal features involved in receptor binding  Academic Article
  • 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase  Academic Article
  • 2,5-diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3)  Academic Article
  • 2-(3,5-dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor  Academic Article
  • 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport  Academic Article
  • 3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting  Academic Article
  • 3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle  Academic Article
  • 3D domain swapping modulates the stability of members of an icosahedral virus group  Academic Article
  • 4-Aminoindazolyl-dihydrofuro 3,4-d pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase  Academic Article
  • A Disorder-to-Order Transition Activates an ATP-Independent Membrane Protein Chaperone  Academic Article
  • A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs  Academic Article
  • A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model  Academic Article
  • A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis  Academic Article
  • A base triple in the tetrahymena group i core affects the reaction equilibrium via a threshold effect  Academic Article
  • A binding site for homeodomain and pax proteins is necessary for l1 cell adhesion molecule gene expression by pax-6 and bone morphogenetic proteins  Academic Article
  • A binding site for pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord  Academic Article
  • A branching reaction mechanism of glutathione reductase  Academic Article
  • A brassinosteroid transcriptional network revealed by genome-wide identification of BESI target genes in Arabidopsis thaliana  Academic Article
  • A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding  Academic Article
  • A cell cycle phosphoproteome of the yeast centrosome  Academic Article
  • A chemical, genetic, and structural analysis of the nuclear bile acid receptor fxr  Academic Article
  • A chemically functionalized magnetic nanoplatform for rapid and specific biomolecular recognition and separation  Academic Article
  • A chromatin binding-site in the tail domain of nuclear lamins that interacts with core histones  Academic Article
  • A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease  Academic Article
  • A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPAR gamma partial agonists  Academic Article
  • A complex assembly landscape for the 30S ribosomal subunit  Academic Article
  • A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis  Academic Article
  • A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles  Academic Article
  • A conserved hiv gp120 glycoprotein structure involved in chemokine receptor binding  Academic Article
  • A conserved motif in the itk ph-domain is required for phosphoinositide binding and tcr signaling but dispensable for adaptor protein interactions  Academic Article
  • A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase  Academic Article
  • A de novo designed peptide ligase: A mechanistic investigation  Academic Article
  • A de novo protein binding pair by computational design and directed evolution  Academic Article
  • A density functional evaluation of an Fe(III)-Fe(IV) model diiron cluster: comparisons with ribonucleotide reductase intermediate X  Academic Article
  • A designed inhibitor of a CLC antiporter blocks function through a unique binding mode  Academic Article
  • A designed synthetic analogue of 4-OT is specific for a non-natural substrate  Academic Article
  • A detailed structural model of cytotactin - protein homologies, alternative rna splicing, and binding regions  Academic Article
  • A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons  Academic Article
  • A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120  Academic Article
  • A dynamic search process underlies microRNA targeting  Academic Article
  • A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol)  Academic Article
  • A flexible interface between DNA ligase and pcna supports conformational switching and efficient ligation of DNA  Academic Article
  • A force field with discrete displaceable waters and desolvation entropy for hydrated ligand docking  Academic Article
  • A four-helical super-secondary structure  Academic Article
  • A fragment of human TrpRS as a potent antagonist of ocular angiogenesis  Academic Article
  • A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia-coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases  Academic Article
  • A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock  Academic Article
  • A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding  Academic Article
  • A g-protein alpha-subunit from asexual candida-albicans functions in the mating signal transduction pathway of saccharomyces-cerevisiae and is regulated by the a1-alpha-2 repressor  Academic Article
  • A galanin-mastoparan chimeric peptide activates the Na+,K(+)-ATPase and reverses its inhibition by ouabain  Academic Article
  • A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells  Academic Article
  • A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans  Academic Article
  • A genetically encoded diazirine photocrosslinker in Escherichia coli  Academic Article
  • A genetically encoded fluorescent amino acid  Academic Article
  • A global benchmark study using affinity-based biosensors  Academic Article
  • A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728  Academic Article
  • A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B  Academic Article
  • A hierarchy of RNA subdomains in assembly of the central domain of the 30 S ribosomal subunit  Academic Article
  • A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs  Academic Article
  • A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV  Academic Article
  • A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein  Academic Article
  • A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS  Academic Article
  • A linear amino acid sequence involved in the interaction of t-PA with its endothelial cell receptor  Academic Article
  • A method for defining binding sites involved in protein-protein interactions: analysis of the binding of plasminogen activator inhibitor 1 to the somatomedin domain of vitronectin  Academic Article
  • A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase  Academic Article
  • A molecular switch regulating transcriptional repression and activation of PPARγ  Academic Article
  • A mutation in the human cyclin-dependent kinase interacting protein, ckshs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly  Academic Article
  • A new decoration for nitric oxide synthase - a zn(cys)4 site  Academic Article
  • A new mechanism of allostery in a G protein-coupled receptor dimer  Academic Article
  • A new model for binding of kinesin 13 to curved microtubule protofilaments  Academic Article
  • A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic c-1027 biosynthesis  Academic Article
  • A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A  Academic Article
  • A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase  Academic Article
  • A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties  Academic Article
  • A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma  Academic Article
  • A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va  Academic Article
  • A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1  Academic Article
  • A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex  Academic Article
  • A novel role of the budding yeast separin esp1 in anaphase spindle elongation: Evidence that proper spindle association of esp1 is regulated by pds1  Academic Article
  • A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity  Academic Article
  • A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site  Academic Article
  • A permutational approach toward protein-DNA recognition  Academic Article
  • A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis  Academic Article
  • A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding  Academic Article
  • A poly(A) binding protein functions in the chloroplast as a message-specific translation factor  Academic Article
  • A positive feedback loop controls transcription of the spoof gene, a component of the sporulation phosphorelay in bacillus-subtilis  Academic Article
  • A protein-S binding-site on C4b-binding protein involves beta-chain residues 31-45  Academic Article
  • A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.Fem-3 mRNA complex  Academic Article
  • A random walk in oncogene space: The quest for targets  Academic Article
  • A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation  Academic Article
  • A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin  Academic Article
  • A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria  Academic Article
  • A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: Crystal structure of spo0f from bacillus subtilis  Academic Article
  • A retroviral-like metal binding motif in an aminoacyl-tRNA synthetase is important for tRNA recognition  Academic Article
  • A reversible reaction inside a self-assembled capsule  Academic Article
  • A ribozyme composed of only two different nucleotides  Academic Article
  • A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus  Academic Article
  • A role for ranbp1 in the release of crm1 from the nuclear pore complex in a terminal step of nuclear export  Academic Article
  • A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280  Academic Article
  • A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib  Academic Article
  • A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis  Academic Article
  • A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases  Academic Article
  • A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta  Academic Article
  • A semisynthetic glutathione peroxidase with high catalytic efficiency: Selenoglutathione transferase  Academic Article
  • A shape-dependent hydrophobic effect for tetrazoles  Academic Article
  • A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth  Academic Article
  • A silencer element in the retinoblastoma tumor-suppressor gene  Academic Article
  • A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity  Academic Article
  • A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure  Academic Article
  • A single gal4 dimer can maximally activate transcription under physiological conditions  Academic Article
  • A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors  Academic Article
  • A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases  Academic Article
  • A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases  Academic Article
  • A small molecule inhibitor selective for a variant atp-binding site of the chaperonin groel  Academic Article
  • A source of response regulator autophosphatase activity: The critical role of a residue adjacent to the spo0f autophosphorylation active site  Academic Article
  • A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor  Academic Article
  • A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle  Academic Article
  • A sphingosine 1-phosphate receptor 2 selective allosteric agonist  Academic Article
  • A stapled p53 helix overcomes HDMX-mediated suppression of p53  Academic Article
  • A steady-state kinetic model of butyrylcholinesterase from horse plasma  Academic Article
  • A steady-state-kinetic random mechanism for glutathione S-transferase A from rat liver. A model involving kinetically significant enzyme-product complexes in the forward reaction  Academic Article
  • A structural model for the high-valent intermediate Q of methane monooxygenase from broken-symmetry density functional and electrostatics calculations  Academic Article
  • A structural model for the prostate disease marker, human prostate-specific antigen  Academic Article
  • A structural perspective of the sequence variability within botulinum neurotoxin subtypes a1-a4  Academic Article
  • A structure-activity study of nociceptin-(1-13)-peptide amide. Synthesis of analogues substituted in positions 0, 1, 3, 4 and 10  Academic Article
  • A structured RNA motif locks Argonaute2:miR-122 onto the 5' end of the HCV genome  Academic Article
  • A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase  Academic Article
  • A synthetic receptor for phosphocholine esters  Academic Article
  • A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease  Academic Article
  • A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen  Academic Article
  • A translation-like cycle is a quality control checkpoint for maturing 40s ribosome subunits  Academic Article
  • A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5  Academic Article
  • A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry  Academic Article
  • A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin mac-1 (cd11b cd18)  Academic Article
  • A universal entropy-driven mechanism for thioredoxin-target recognition  Academic Article
  • A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities  Academic Article
  • ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair  Academic Article
  • ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization  Academic Article
  • ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase  Academic Article
  • Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: The 3 ' ends justify the means  Academic Article
  • Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: Formation of a pterin radical is required for enzyme activity  Academic Article
  • Ablating adenovirus type 5 fiber-car binding and hi loop insertion of the sigyplp peptide generate an endothelial cell-selective adenovirus  Academic Article
  • Absence of G(i) proteins in the Sf9 insect cell. Characterization of the uncoupled recombinant N-formyl peptide receptor  Academic Article
  • Acceptor helix interactions in a class II tRNA synthetase: photoaffinity cross-linking of an RNA miniduplex substrate  Academic Article
  • Acceptor substrate-based selective inhibition of galactosyltransferases  Academic Article
  • Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gpl120 is sterically restricted on primary human immunodeficiency virus type 1  Academic Article
  • Accessibility of nuclear chromatin by DNA binding polyamides  Academic Article
  • Acetylcholine recognition by a deep, biomimetic pocket  Academic Article
  • Acidophilic adaptations in the structure of Acetobacter aceti N-5-carboxyaminoimidazole ribonucleotide mutase (PurE)  Academic Article
  • Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements  Academic Article
  • Activation of Hageman factor in solid and fluid phases. A critical role of kallikrein  Academic Article
  • Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1  Academic Article
  • Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete c-terminal domain  Academic Article
  • Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the a subunits  Academic Article
  • Activation of the redox-regulated chaperone hsp33 by domain unfolding  Academic Article
  • Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation  Academic Article
  • Active and alkylated human agt structures: A novel zinc site, inhibitor and extrahelical base binding  Academic Article
  • Active and inhibited human catalase structures: Ligand and nadph binding and catalytic mechanism  Academic Article
  • Active site binding modes of curcumin in HIV-1 protease and integrase  Academic Article
  • Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense  Academic Article
  • Active site modification of factor viia affects interactions of the protease domain with tissue factor  Academic Article
  • Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein  Academic Article
  • Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties  Academic Article
  • Active site residues of cyclophilin A are crucial for its signaling activity via CD147  Academic Article
  • Active site structure of Rieske-type proteins: electron nuclear double resonance studies of isotopically labeled phthalate dioxygenase from Pseudomonas cepacia and Rieske protein from Rhodobacter capsulatus and molecular modeling studies of a Rieske center  Academic Article
  • Active site structure of class I ribonucleotide reductase intermediate X: a density functional theory analysis of structure, energetics, and spectroscopy  Academic Article
  • Active site-directed inhibition of rabbit cytochrome P-450 1 by amino-substituted steroids  Academic Article
  • Active thymus derived suppressor lymphocytes in human cord blood  Academic Article
  • Active, interactive, and inactive steroid-receptor mutants  Academic Article
  • Active-site and oligosaccharide recognition residues of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f  Academic Article
  • Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3  Academic Article
  • Activity-based protein profiling for the functional annotation of enzymes  Academic Article
  • Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid)  Academic Article
  • Adaptation of influenza viruses to human airway receptors  Academic Article
  • Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2  Academic Article
  • Adding L-3-(2-naphthyl)alanine to the genetic code of E. coli  Academic Article
  • Addition of an alpha-hydroxy acid to the genetic code of bacteria  Academic Article
  • Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope  Academic Article
  • Adenosine: a partial agonist of the growth hormone secretagogue receptor  Academic Article
  • Adhesive properties of the isolated amino-terminal domain of platelet glycoprotein Ib alpha in a flow field  Academic Article
  • Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenge  Academic Article
  • Advances in pain therapeutics  Academic Article
  • Affinity labeling of creatine kinase by N-(2,3-epoxypropyl)-N-amidinoglycine  Academic Article
  • Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling  Academic Article
  • Agonist-bound structure of the human P2Y(12) receptor  Academic Article
  • Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence  Academic Article
  • Alanine scanning mutagenesis of an alpha beta T cell receptor: mapping the energy of antigen recognition  Academic Article
  • Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA  Academic Article
  • Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition  Academic Article
  • Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase  Academic Article
  • Aldehyde dehydrogenase inhibitors: A comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application  Academic Article
  • Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors  Academic Article
  • Allosteric inhibition of hypoxia inducible factor-2 with small molecules  Academic Article
  • Allosteric inhibition via R-state destabilization in ATP sulfurylase from Penicillium chrysogenum  Academic Article
  • Alternative outcomes in assembly of promoter complexes: The roles of TBP and a flexible linker in placing TFIIIB on tRNA genes  Academic Article
  • Amino acid derived quinazolines as Rock/PKA inhibitors  Academic Article
  • Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles  Academic Article
  • Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib  Academic Article
  • Amino acid substitution at the dimeric interface of human manganese superoxide dismutase  Academic Article
  • Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase  Academic Article
  • Aminoacylation of RNA minihelices: implications for tRNA synthetase structural design and evolution  Academic Article
  • Aminoglycoside binding in the major groove of duplex rna: The thermodynamic and electrostatic forces that govern recognition  Academic Article
  • Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase  Academic Article
  • An AP-1 site is involved in the NGF induction of IL-1α in PC12 cells  Academic Article
  • An Engineered Arginine Residue of Unusual pH-Sensitive Reactivity Facilitates Site-Selective Antibody Conjugation  Academic Article
  • An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines  Academic Article
  • An L-RNA aptamer that binds and inhibits RNase  Academic Article
  • An NMR perspective on enzyme dynamics  Academic Article
  • An RNA binding site in a tRNA synthetase with a reduced set of amino acids  Academic Article
  • An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors  Academic Article
  • An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide  Academic Article
  • An acyloxymethyl ketone-based probe to monitor the activity of glutathionylspermidine amidase in Escherichia coli  Academic Article
  • An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1  Academic Article
  • An alternate binding site for PPARγ ligands  Academic Article
  • An alternative processing of integrin αv subunit in tumor cells by membrane type-1 matrix metalloproteinase  Academic Article
  • An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance  Academic Article
  • An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode  Academic Article
  • An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription  Academic Article
  • An analysis of a class of DNA sequence reading molecules  Academic Article
  • An aptamer that neutralizes r5 strains of hiv-1 binds to core residues of gp120 in the ccr5 binding site  Academic Article
  • An aptamer that neutralizes r5 strains of human immunodeficiency virus type 1 blocks gp120-ccr5 interaction  Academic Article
  • An engineered mutant of hiv-1 gp120 formulated with adjuvant quil a promotes elicitation of antibody responses overlapping the cd4-binding site  Academic Article
  • An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured  Academic Article
  • An essential histidine residue in the catalytic mechanism of mammalian glutathione reductase  Academic Article
  • An essential role for the conserved Glu-133 in the anion interaction with superoxide-dismutase  Academic Article
  • An evolutionary approach to the design of glutathione-linked enzymes  Academic Article
  • An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity  Academic Article
  • An improved zinc-finger nuclease architecture for highly specific genome editing  Academic Article
  • An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation  Academic Article
  • An inhibitor of sequence-specific proteolysis that targets the substrate rather than the enzyme  Academic Article
  • An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity  Academic Article
  • An integrated map of genetic variation from 1,092 human genomes  Academic Article
  • An intramolecular signaling element that modulates dynamin function in vitro and in vivo  Academic Article
  • An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin 5  Academic Article
  • An o-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses  Academic Article
  • An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution  Academic Article
  • An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7  Academic Article
  • An operational RNA code for amino acids and variations in critical nucleotide sequences in evolution  Academic Article
  • An oxetane-based polyketide surrogate To probe substrate binding in a polyketide synthase  Academic Article
  • An unusual dimeric structure and assembly for tlr4 regulator rp105-md-1  Academic Article
  • Analysis of bacteriophage N protein and peptide binding to boxB RNA using polyacrylamide gel coelectrophoresis (PACE)  Academic Article
  • Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes  Academic Article
  • Analysis of hapten binding and catalytic determinants in a family of catalytic antibodies  Academic Article
  • Analysis of structure-function relationships in the platelet membrane glycoprotein Ib-binding domain of von Willebrand's factor by expression of deletion mutants  Academic Article
  • Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo  Academic Article
  • Analysis of the class i aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99 Å resolution  Academic Article
  • Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity  Academic Article
  • Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera  Academic Article
  • Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: Insight into the chaotrope unfolding dichotomy  Academic Article
  • Anisotropic molecular rotational diffusion in n-15 spin relaxation studies of protein mobility  Academic Article
  • Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists  Academic Article
  • Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres  Academic Article
  • Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones  Academic Article
  • Anti-diabetic drug binding site in a mammalian K-ATP channel revealed by Cryo-EM  Academic Article
  • Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen  Academic Article
  • Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides  Academic Article
  • Antibodies raised against beta-adrenergic receptors stimulate adenylate-cyclase  Academic Article
  • Antibody 2g12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the hiv-1 glycan shield if domain exchanged  Academic Article
  • Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike  Academic Article
  • Antibody binding defines a structure for an epitope that participates in the prpc -> prpsc conformational change  Academic Article
  • Antibody catalysis of the oxidation of water  Academic Article
  • Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics  Academic Article
  • Antibody microarrays utilizing site-specific antibody-oligonucleotide conjugates  Academic Article
  • Antibody neutralization epitopes and integrin binding sites on nonenveloped viruses  Academic Article
  • Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env  Academic Article
  • Antibody structure and molecular immunology  Academic Article
  • Antibody structure, diversity, and specificity  Academic Article
  • Antibody vs. HIV in a clash of evolutionary titans  Academic Article
  • Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions  Academic Article
  • Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation  Academic Article
  • Anticodon G recognition by tRNA synthetases mimics the tRNA core  Academic Article
  • Antifungal azoles: structural insights into undesired tight binding to cholesterol-metabolizing CYP46A1  Academic Article
  • Antigen recognition by variable lymphocyte receptors  Academic Article
  • Antiidiotype and antihormone receptor antibodies  Academic Article
  • Antimitotic agents of natural origin  Academic Article
  • Ap-2/eps15 interaction is required for receptor-mediated endocytosis  Academic Article
  • Apo raver1 structure reveals distinct RRM domain orientations  Academic Article
  • Application of nuclear magnetic-resonance spectroscopy to proteins  Academic Article
  • Approaches toward selective inhibition of nitric oxide synthase  Academic Article
  • Aptly named aptamers display their aptitude  Academic Article
  • Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation  Academic Article
  • Archaeal flagellar atpase motor shows atp-dependent hexameric assembly and activity stimulation by specific lipid binding  Academic Article
  • Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors  Academic Article
  • Architecture of the mediator head module  Academic Article
  • Arginine-54 in the active-site of escherichia-coli aspartate transcarbamoylase is critical for catalysis - a site-specific mutagenesis, NMR, and x-ray crystallographic study  Academic Article
  • Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions  Academic Article
  • Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor  Academic Article
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  • Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 Å resolution  Academic Article
  • Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A  Academic Article
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  • Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif  Academic Article
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  • Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution  Academic Article
  • Crystal structure of Pasteurella haemolytica ferric ion-binding protein a reveals a novel class of bacterial iron-binding proteins  Academic Article
  • Crystal structure of TM1367 from Thermotoga maritima at 1.90 Å resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold  Academic Article
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  • Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis  Academic Article
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  • Crystal structure of a divalent metal ion transporter CorA at 2.9 Å resolution  Academic Article
  • Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold  Academic Article
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  • Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity  Academic Article
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  • Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 Å resolution  Academic Article
  • Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 Å resolution  Academic Article
  • Crystal structure of a phosphatase-resistant mutant of sporulation response regulator spo0f from bacillus subtilis  Academic Article
  • Crystal structure of a putative NADPH-dependent oxidoreductase (GI : 18204011) from mouse at 2.10 Å resolution  Academic Article
  • Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 Å resolution  Academic Article
  • Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 a resolution  Academic Article
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  • Crystal structure of botulinum neurotoxin type g light chain: Serotype divergence in substrate recognition  Academic Article
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  • Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping  Academic Article
  • Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue  Academic Article
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  • Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 Å-resolution  Academic Article
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  • Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose  Academic Article
  • Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide  Academic Article
  • Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran  Academic Article
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  • Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A  Academic Article
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  • Crystal structure of the spindle assembly checkpoint protein Bub3  Academic Article
  • Crystal structure of the transcriptional repressor pagr of bacillus anthracis  Academic Article
  • Crystal structure of the von Willebrand factor modulator botrocetin  Academic Article
  • Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892  Academic Article
  • Crystal structure of tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex  Academic Article
  • Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases  Academic Article
  • Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 Å resolution: Self-hydroxylation of phe300 and the pterin-binding site  Academic Article
  • Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin  Academic Article
  • Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34  Academic Article
  • Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis  Academic Article
  • Crystal structures of a quorum-quenching antibody  Academic Article
  • Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP  Academic Article
  • Crystal structures of apolipoprotein(a) kringle iv37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: Existence of novel and expected binding modes  Academic Article
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  • Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR  Academic Article
  • Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates  Academic Article
  • Crystal structures of human topoisomerase i in covalent and noncovalent complexes with DNA  Academic Article
  • Crystal structures of leukotriene a(4) hydrolase in complex with captopril and two competitive tight-binding inhibitors  Academic Article
  • Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands  Academic Article
  • Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors  Academic Article
  • Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain  Academic Article
  • Crystal structures of the free and liganded form of an esterolytic catalytic antibody  Academic Article
  • Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor  Academic Article
  • Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake  Academic Article
  • Crystal structures of transhydrogenase domain i with and without bound nadh  Academic Article
  • Crystal structures of two I-A(d)-peptide complexes reveal that high affinity can be achieved without large anchor residues  Academic Article
  • Crystal structures of two rat mhc class ia (rt1-a) molecules that are associated differentially with peptide transporter alleles tap-a and tap-b  Academic Article
  • Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains  Academic Article
  • Crystal-structure and mutational analysis of human uracil-DNA glycosylase - structural basis for specificity and catalysis  Academic Article
  • Crystal-structure of an h-2k(b)-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove  Academic Article
  • Crystal-structure of cd,zn metallothionein  Academic Article
  • Crystal-structure of human uracil-DNA glycosylase in complex with a protein inhibitor - protein mimicry of DNA  Academic Article
  • Crystal-structure of murine cyclophilin-c complexed with immunosuppressive drug cyclosporine-a  Academic Article
  • Crystal-structure of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f at 2.2 Å resolution  Academic Article
  • Crystal-structure of the human cell-cycle protein ckshs1 - single-domain fold with similarity to kinase n-lobe domain  Academic Article
  • Crystal-structures of 2 viral peptides in complex with murine mhc class-i h-2k(b)  Academic Article
  • Crystal-structures of a schistosomal drug and vaccine target - glutathione-s-transferase from schistosoma-japonica and its complex with the leading antischistosomal drug praziquantel  Academic Article
  • Crystal-structures of aconitase with isocitrate and nitroisocitrate bound  Academic Article
  • Crystal-structures of aconitase with trans-aconitate and nitrocitrate bound  Academic Article
  • Crystallization and preliminary x-ray crystallographic analysis of aart, a designed six-finger zinc-finger peptide, bound to DNA  Academic Article
  • Crystallographic analysis of 2 site-directed mutants of azotobacter-vinelandii ferredoxin  Academic Article
  • Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG  Academic Article
  • Crystallographic fragment-based drug discovery: use of a brominated fragment library targeting HIV protease  Academic Article
  • Cu,Zn superoxide dismutase structure from a microbial pathogen establishes a class with a conserved dimer interface  Academic Article
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  • Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins  Academic Article
  • Custom zinc-finger nucleases for use in human cells  Academic Article
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  • Cyclin-dependent kinases 5 template: useful for virtual screening  Academic Article
  • Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation  Academic Article
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  • Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites  Academic Article
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  • CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis  Academic Article
  • Cysteine residues are not essential for the catalytic activity of human class Mu glutathione transferase M1a-1a  Academic Article
  • Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import  Academic Article
  • Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif  Academic Article
  • D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain  Academic Article
  • DNA apurinic-apyrimidinic site binding and excision by endonuclease iv  Academic Article
  • DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex  Academic Article
  • DNA binding and nucleotide flipping by the human DNA repair protein agt  Academic Article
  • DNA loops induced by cooperative binding of transcriptional activator proteins and preinitiation complexes  Academic Article
  • DNA protein complexes during attachment-site synapsis in Mu DNA transposition  Academic Article
  • DNA recognition by a σ(54) transcriptional activator from Aquifex aeolicus  Academic Article
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  • Definition of the binding-sites of individual zinc fingers in the transcription factor-IIIA-5S RNA gene-complex  Academic Article
  • Delineation of spontaneous erythrocyte autoantibody responses of nzb and other strains of mice  Academic Article
  • Delineation of the peptide binding site of the human galanin receptor  Academic Article
  • Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: Noncovalent binding coincidental with alkylation  Academic Article
  • Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit  Academic Article
  • Demonstration of circulating immune complexes in Sjögren's syndrome  Academic Article
  • Density functional and electrostatics study of oxidized and reduced ribonucleotide reductase: comparisons with methane monooxygenase  Academic Article
  • Density functional calculation of pKa values and redox potentials in the bovine Rieske iron-sulfur protein  Academic Article
  • Density functional studies of oxidized and reduced methane monooxygenase. Optimized geometries and exchange coupling of active site clusters  Academic Article
  • Density functional theory study of Fe(IV) d-d optical transitions in active-site models of class I ribonucleotide reductase intermediate X with vertical self-consistent reaction field methods  Academic Article
  • Derivation of a retinoid x receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1h-indol-3-yl)methyl-4-trifluoromethylbenzene  Academic Article
  • Design and characterization of an active site selective caspase-3 transnitrosating agent  Academic Article
  • Design and evolution of new catalytic activity with an existing protein scaffold  Academic Article
  • Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives  Academic Article
  • Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300  Academic Article
  • Design and synthesis of c5 methylated l-arginine analogues as active site probes for nitric oxide synthase  Academic Article
  • Design and synthesis of novel CCR2 antagonists: Investigation of non-aryl/heteroaryl binding motifs  Academic Article
  • Design and synthesis of selenazole-containing peptides for cocrystallization with p-glycoprotein  Academic Article
  • Design of a functional membrane protein by engineering a heme-binding site in glycophorin A  Academic Article
  • Design of a redox-linked active metal site: manganese bound to bacterial reaction centers at a site resembling that of photosystem II  Academic Article
  • Design of allele-specific protein methyltransferase inhibitors  Academic Article
  • Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site  Academic Article
  • Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d  Academic Article
  • Design of polydactyl zinc-finger proteins for unique addressing within complex genomes  Academic Article
  • Design of potent and selective 2-aminobenzimidazole-based p38 alpha MAP kinase inhibitors with excellent in vivo efficacy  Academic Article
  • Design of stapled DNA-minor-groove-binding molecules with a mutable atom simulated annealing method  Academic Article
  • Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors  Academic Article
  • Design, synthesis and evaluation of 2,5-diketopiperazines as inhibitors of the MDM2-p53 interaction  Academic Article
  • Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors  Academic Article
  • Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants  Academic Article
  • Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators  Academic Article
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  • Designing transcription factor architectures for drug discovery  Academic Article
  • Detection of a catalytic antibody species acylated at the active site by electrospray mass spectrometry  Academic Article
  • Detection of a ternary complex of nf-kappa b and i kappa b alpha with DNA provides insights into how i kappa b alpha removes nf-kappa b from transcription sites  Academic Article
  • Detection of leucine-independent DNA site occupancy of the yeast Leu3p transcriptional activator in vivo  Academic Article
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  • Determination and analysis of the 2A structure of copper, zinc superoxide-dismutase  Academic Article
  • Determination of matrix metalloproteinase activity using biotinylated gelatin  Academic Article
  • Determination of the 3-dimensional structure of metallothioneins by nuclear-magnetic-resonance spectroscopy in solution  Academic Article
  • Determination of the NMR solution structure of the cyclophilin-a - cyclosporine-a complex  Academic Article
  • Determination of the coordination geometry at the heme iron in 3 cytochromes-c from saccharomyces-cerevisiae and from candida-krusei based on individual h-1-NMR assignments for heme-c and the axially coordinated amino-acids  Academic Article
  • Determination of the nuclear-magnetic-resonance solution structure of the DNA-binding domain (residues 1 to 69) of the 434 repressor and comparison with the x-ray crystal-structure  Academic Article
  • Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface  Academic Article
  • Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair  Academic Article
  • Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor  Academic Article
  • Development of 5N-bicalutamide, a high-affinity reversible covalent antiandrogen  Academic Article
  • Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors  Academic Article
  • Development of Pseudomonas aeruginosa lectin LecA inhibitor by using bivalent galactosides supported on polyproline peptide scaffolds  Academic Article
  • Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors  Academic Article
  • Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties  Academic Article
  • Development of new enzymatic catalysts for peptide-synthesis in aqueous and organic-solvents  Academic Article
  • Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: Defining the binding mode of 7-oxabicyclo 2.2.1 hept-5-ene scaffold core ligands  Academic Article
  • Development of sulfonamide photoaffinity inhibitors for probing cellular γ-secretase  Academic Article
  • Development of thioquinazolinones, allosteric Chk1 kinase inhibitors  Academic Article
  • Development of zinc finger domains for recognition of the 5 '-ann-3 ' family of DNA sequences and their use in the construction of artificial transcription factors  Academic Article
  • Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies  Academic Article
  • Developmentally regulated proteins of plasma-membrane of dictyostelium-discoideum - carbohydrate-binding protein  Academic Article
  • Dextran as a generally applicable multivalent scaffold for improving immunoglobulin-binding affinities of peptide and peptidomimetic ligands  Academic Article
  • Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes  Academic Article
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  • Differential infection of receptor-modified host-cells by receptor-specific influenza-viruses  Academic Article
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  • Difficulties in determining accurate molecular-motion parameters from proton relaxation enhancement measurements as illustrated by immunoglobulin-g . Gd(iii) system  Academic Article
  • Dimerization of the klenow fragment of escherichia coli DNA polymerase i is linked to its mode of DNA binding  Academic Article
  • Direct association between the yeast rad51 and rad54 recombination proteins  Academic Article
  • Direct evidence for manganese(iii) binding to manganosuperoxide dismutase of escherichia-coli-b  Academic Article
  • Direct measurement of the aspartic acid 26 pK(a) for reduced Escherichia coli thioredoxin by (13)C NMR  Academic Article
  • Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance  Academic Article
  • Direct regulation of clock expression by rev-erb  Academic Article
  • Directed evolution of a bright near-infrared fluorescent rhodopsin using a synthetic chromophore  Academic Article
  • Directed evolution of d-sialic acid aldolase to l-3-deoxy-manno-2-octulosonic acid (l-kdo) aldolase  Academic Article
  • Directed evolution of the TALE N-terminal domain for recognition of all 5' bases  Academic Article
  • Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model  Academic Article
  • Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II)  Academic Article
  • Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)  Academic Article
  • Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors  Academic Article
  • Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering  Academic Article
  • Discovery of a small molecule insulin mimetic with antidiabetic activity in mice  Academic Article
  • Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library  Academic Article
  • Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors  Academic Article
  • Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design  Academic Article
  • Discovery of potent and bioavailable GSK-3β inhibitors  Academic Article
  • Discovery of potent and selective covalent inhibitors of JNK  Academic Article
  • Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists  Academic Article
  • Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor's potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations  Academic Article
  • Discovery of protein phosphatase 2C inhibitors by virtual screening  Academic Article
  • Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase i7l using homology modeling and covalent docking approaches  Academic Article
  • Discrete determinants in transfer RNA for editing and aminoacylation  Academic Article
  • Discriminated selection among viral peptides with the appropriate anchor residues - implications for the size of the cytotoxic t-lymphocyte repertoire and control of viral-infection  Academic Article
  • Discrimination between steady-state kinetic models of the mechanism of action of yeast glyoxalase I  Academic Article
  • Dismissal of RNA polymerase II underlies a large ligand-induced enhancer decommissioning program  Academic Article
  • Disorder-to-order transition of the active site of human class Pi glutathione transferase, GST P1-1  Academic Article
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  • Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F  Academic Article
  • Dissecting the neutralizing antibody-specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors  Academic Article
  • Dissection of a class II tRNA synthetase: determinants for minihelix recognition are tightly associated with domain for amino acid activation  Academic Article
  • Dissection of an antibody-catalyzed reaction  Academic Article
  • Dissociation of clathrin coats coupled to the hydrolysis of atp - role of an uncoating atpase  Academic Article
  • Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs  Academic Article
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  • Distinct domains of tRNA synthetase recognize the same base pair  Academic Article
  • Distinct structural attributes regulating von Willebrand factor A1 domain interaction with platelet glycoprotein Ib alpha under flow  Academic Article
  • Distinguishing binders from false positives by free energy calculations: fragment screening against the flap site of HIV protease  Academic Article
  • Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes  Academic Article
  • Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin  Academic Article
  • Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors  Academic Article
  • Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2  Academic Article
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  • Docking of 4-oxalocrotonate tautomerase substrates: implications for the catalytic mechanism  Academic Article
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  • Gp120: Biologic aspects of structural features  Academic Article
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  • H-1-NMR studies of the coordination geometry at the heme iron and the electronic-structure of the heme group in cytochrome-c-552 from euglena-gracilis  Academic Article
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  • HIV-1 mRNA 3' end processing is distinctively regulated by elF3f, CDK11, and splice factor 9G8  Academic Article
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  • Heme stoichiometry of heterodimeric soluble guanylate cyclase  Academic Article
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  • Hepatocyte nuclear factor-4-independent synthesis of coagulation factor vii in breast cancer cells and its inhibition by targeting selective histone acetyltransferases  Academic Article
  • Heterocyclic derivatives of 2-(3,5-dimethylphenyl)tryptamine as GnRH receptor antagonists  Academic Article
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  • High throughput screening of potentially selective mmp-13 exosite inhibitors utilizing a triple-helical fret substrate  Academic Article
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  • Human antibody effector function  Academic Article
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  • Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the α2δ-1 subunit of voltage gated calcium channel  Academic Article
  • Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase  Academic Article
  • Identification of 50S components neighboring 23S rRNA nucleotides A2448 and U2604 within the peptidyl transferase center of Escherichia coli ribosomes  Academic Article
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  • Identification of Gal4 activation domain-binding proteins in the 26S proteasome by periodate-triggered cross-linking  Academic Article
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  • Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB  Academic Article
  • Identification of a lipid-a binding-site in the acute phase reactant lipopolysaccharide binding-protein  Academic Article
  • Identification of a minimal domain of 5 S ribosomal RNA sufficient for high affinity interactions with the RNA-specific zinc fingers of transcription factor IIIA  Academic Article
  • Identification of a new cryptochrome class: Structure, function, and evolution  Academic Article
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  • Identification of a p53 binding-site in the human retinoblastoma susceptibility gene promoter  Academic Article
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  • Identification of a regulatory domain of the interleukin-6 receptor  Academic Article
  • Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding  Academic Article
  • Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)  Academic Article
  • Identification of an N-formyl peptide receptor ligand binding domain by a gain-of-function approach  Academic Article
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  • Identification of an epitope of alpha-enolase (a candidate plasminogen receptor) by phage display  Academic Article
  • Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors  Academic Article
  • Identification of covalent bromodomain binders through DNA display of small molecules  Academic Article
  • Identification of critical active-site residues in the multifunctional human DNA-repair enzyme hap1  Academic Article
  • Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin. A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib  Academic Article
  • Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays  Academic Article
  • Identification of endogenous ligands bound to bacterially expressed human and E. coli dihydrofolate reductase by 2D NMR  Academic Article
  • Identification of histidine and methionine residues in the active site of the human uterine progesterone receptor with the affinity labels 11 alpha- and 16 alpha-(bromoacetoxy)progesterone  Academic Article
  • Identification of inhibitors of the E. coli chaperone SurA using in silico and in vitro techniques  Academic Article
  • Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor  Academic Article
  • Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility  Academic Article
  • Identification of novel binding elements and gene targets for the homeodomain protein BARX2  Academic Article
  • Identification of novel macrocyclic peptidase substrates via on-bead enzymatic cyclization  Academic Article
  • Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds  Academic Article
  • Identification of potent Yes1 kinase inhibitors using a library screening approach  Academic Article
  • Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta  Academic Article
  • Identification of residues 413-433 of plasma protein S as essential for binding to C4b-binding protein  Academic Article
  • Identification of residues in TIP47 essential for Rab9 binding  Academic Article
  • Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay  Academic Article
  • Identification of specific binding-proteins for a nuclear location sequence  Academic Article
  • Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase  Academic Article
  • Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor viia  Academic Article
  • Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis  Academic Article
  • Identification of the dicyclohexylcarbodiimide-binding subunit of nadh-ubiquinone oxidoreductase (complex-i)  Academic Article
  • Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate  Academic Article
  • Identification of the nadh-binding subunit of energy-transducing nadh-quinone oxidoreductase (ndh-1) of thermus thermophilus hb-8  Academic Article
  • Identification of the nadh-binding subunit of nadh-ubiquinone oxidoreductase of paracoccus-denitrificans  Academic Article
  • Identification of the regions involved in DNA binding by the mouse PEBP2alpha protein  Academic Article
  • Identification of the zinc ligands in cobalamin-independent methionine synthase (MetE) from Escherichia coli  Academic Article
  • Identification of transcription factor binding sites in the human genome sequence  Academic Article
  • Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides  Academic Article
  • Idiographic representation of conserved domain of a class II tRNA synthetase of unknown structure  Academic Article
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  • Immunological memory to hyperphosphorylated tau in asymptomatic individuals  Academic Article
  • Immunological mimicry by a monoclonal-antibody of the tricyclic anti-depressants binding-site on muscarinic acetylcholine-receptors  Academic Article
  • Immunological origins of binding and catalysis in a Diels-Alderase antibody  Academic Article
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  • Implications for the domain arrangement of axonin-1 derived from the mapping of its NgCAM binding site  Academic Article
  • Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor  Academic Article
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  • Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs  Academic Article
  • Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation  Academic Article
  • Importance of minor groove binding zinc fingers within the transcription factor IIIA-DNA complex  Academic Article
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  • Improved design of an antigen with enhanced specificity for the broadly hiv-neutralizing antibody b12  Academic Article
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  • In vitro analysis of nuclear transport mediated by the c-terminal shuttle domain of tap  Academic Article
  • In vitro selection of nucleic acids and proteins: what are we learning?  Academic Article
  • In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for icam-1 provides new insights into gene regulation  Academic Article
  • In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase  Academic Article
  • In vivo, in vitro, and molecular aspects of interleukin-8 and the interleukin-8 receptors  Academic Article
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  • Independent assembly and secretion of a dimeric adhesive domain of von Willebrand factor containing the glycoprotein Ib-binding site  Academic Article
  • Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody  Academic Article
  • Individual h-1-NMR assignments for the heme groups and the axially bound amino-acids and determination of the coordination geometry at the heme iron in a mixture of 2 isocytochromes-c-551 from rhodopseudomonas-gelatinosa  Academic Article
  • Inducible nitric oxide synthase: Role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction  Academic Article
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  • Influence of cofactor binding and active site occupancy on the conformation of the macromolecular substrate exosite of factor viia  Academic Article
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  • Influence of novel cd4 binding-defective hiv-1 envelope glycoprotein immunogens on neutralizing antibody and t-cell responses in nonhuman primates  Academic Article
  • Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein  Academic Article
  • Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity  Academic Article
  • Inherent protein structural flexibility at the RNA-binding interface of L30e  Academic Article
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  • Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors  Academic Article
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  • Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-kappa B, and DNA by a designed DNA-binding ligand  Academic Article
  • Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes  Academic Article
  • Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands  Academic Article
  • Inhibition of a viral enzyme by a small-molecule dimer disruptor  Academic Article
  • Inhibition of cytochrome p-450 activity in rat liver microsomes by the naturally occurring flavonoid, quercetin  Academic Article
  • Inhibition of glutathione reductase by interaction of 2, 4, 6-trinitrobenzenesulfonate with the active-site dithiol  Academic Article
  • Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site  Academic Article
  • Inhibition of proteolysis and other posttranslational modifications with substrate-targeted inhibitors  Academic Article
  • Inhibitor focusing: direct selection of drug targets from proteomes using activity-based probes  Academic Article
  • Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase  Academic Article
  • Inscribing the perimeter of the PagP hydrocarbon ruler by site-specific chemical alkylation  Academic Article
  • Insertion of new sequences into the catalytic domain of an enzyme  Academic Article
  • Insight into the sporulation phosphorelay: Crystal structure of the sensor domain of Bacillus subtilis histidine kinase, KinD  Academic Article
  • Insights into PPAR gamma from structures with endogenous and covalently bound ligands  Academic Article
  • Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9 Å resolution  Academic Article
  • Insights into the mode of action of a putative zinc transporter czrb in thermus thermophilus  Academic Article
  • Insights into the nature of DNA binding of AbrB-like transcription factors  Academic Article
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  • Integrating folding kinetics and protein function: biphasic kinetics and dual binding specificity in a WW domain  Academic Article
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  • Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage  Academic Article
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  • Interaction between the cell-cycle-control proteins p34cdc2 and p9ckshs2 - evidence for 2 cooperative binding domains in p9ckshs2  Academic Article
  • Interaction interface of human flap endonuclease-1 with its DNA substrates  Academic Article
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  • Interaction of Lp(a) with plasminogen binding sites on cells  Academic Article
  • Interaction of colchicine and some related alkaloids with rat-brain tubulin  Academic Article
  • Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II  Academic Article
  • Interaction of epothilone analogs with the paclitaxel binding site: Relationship between binding affinity, microtubule stabilization, and cytotoxicity  Academic Article
  • Interaction of human hemoglobin with adenine nucleotides  Academic Article
  • Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites  Academic Article
  • Interaction of lysozyme with alpha-N-acetyl-D-glucosamine  Academic Article
  • Interaction of manganese with fragments, complementary fragment recombinations, and whole molecules of yeast phenylalanine specific transfer RNA  Academic Article
  • Interaction of polyamines with fragments and whole molecules of yeast phenylalanine-specific transfer RNA  Academic Article
  • Interaction of the RNA-binding fingers of Xenopus transcription factor IIIA with specific regions of 5-S ribosomal-RNA  Academic Article
  • Interaction of the mediator head module with RNA polymerase II  Academic Article
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  • Interaction of urea with an unfolded protein - the DNA-binding domain of the 434-repressor  Academic Article
  • Interaction of xenopus TFIIIC with the TFIIIA.5-S RNA gene-complex  Academic Article
  • Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin  Academic Article
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  • Interactions of Qβ replicase with Qβ RNA  Academic Article
  • Interactions of active-site residues and catalytic activity of human carbonic anhydrase III  Academic Article
  • Interactions of bovine neurophysin-II with oxytocin and 8-lysine vasopressin - high-resolution proton nuclear magnetic-resonance spectroscopy studies  Academic Article
  • Interactions of soluble recombinant integrin alpha v beta 5 with human adenoviruses  Academic Article
  • Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression  Academic Article
  • Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta (C/EBP beta)  Academic Article
  • Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue  Academic Article
  • Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin  Academic Article
  • Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells  Academic Article
  • Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase  Academic Article
  • Investigation of the PDZ domain ligand binding site using chemically modified peptides  Academic Article
  • Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters  Academic Article
  • Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein  Academic Article
  • Involvement of an active-site Zn2+ ligand mechanism of human glyoxalase I  Academic Article
  • Iron superoxide-dismutase from escherichia-coli at 3.1-a resolution - a structure unlike that of copper-zinc protein at both monomer and dimer levels  Academic Article
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  • Isoform-selective and stereoselective inhibition of hypoxia inducible factor-2  Academic Article
  • Isolated RNA binding domain of a class I tRNA synthetase  Academic Article
  • Isolation and characterization of a collagen binding domain in human von Willebrand factor  Academic Article
  • Isolation and characterization of maclura pomifera (mp) lectin  Academic Article
  • Isolation and characterization of the DNA and protein binding activities of adenovirus core protein V  Academic Article
  • Isolation and functional characterization of the von Willebrand factor-binding domain located between residues His1-Arg293 of the alpha-chain of glycoprotein Ib  Academic Article
  • Isolation and sequence-specific DNA-binding of the antennapedia homeodomain  Academic Article
  • Isolation of lectins of different specificities on a single affinity adsorbent  Academic Article
  • Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model  Academic Article
  • Isolation of the von Willebrand factor domain interacting with platelet glycoprotein Ib, heparin, and collagen and characterization of its three distinct functional sites  Academic Article
  • Isothermal titration calorimetry and surface plasmon resonance allow quantifying substrate binding to different binding sites of Bacillus subtilis xylanase  Academic Article
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  • Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress  Academic Article
  • Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein tpr  Academic Article
  • Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP  Academic Article
  • Kinetic analysis of integrin-dependent cell adhesion on vitronectin: the inhibitory potential of plasminogen activator inhibitor-1 and RGD peptides  Academic Article
  • Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase  Academic Article
  • Kinetic analysis of the interaction between type 1 plasminogen activator inhibitor and vitronectin and evidence that the bovine inhibitor binds to a thrombin-derived amino-terminal fragment of bovine vitronectin  Academic Article
  • Kinetic analysis of the interaction between vitronectin and the urokinase receptor  Academic Article
  • Kinetic and spectroscopic evidence for three actomyosin : Adp states in smooth muscle  Academic Article
  • Kinetic and stoichiometric characterisation of streptavidin-binding aptamers  Academic Article
  • Kinetic independence of the subunits of cytosolic glutathione transferase from the rat  Academic Article
  • Kinetic intermediates trapped by native interactions in RNA folding  Academic Article
  • Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3 alpha 1  Academic Article
  • Kinetic mechanism of RGS9-1 potentiation by R9AP  Academic Article
  • Kinetics and mechanisms of reduction of cu(ii) and fe(iii) complexes by soybean leghemoglobin-alpha  Academic Article
  • Kinetics and mechanisms of the oxidation of myoglobin by fe(iii) and cu(ii) complexes  Academic Article
  • Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of udp-glcnac enolpyruvoyl transferase by the antibiotic fosfomycin  Academic Article
  • Kinomics-structural biology and chemogenomics of kinase inhibitors and targets  Academic Article
  • Kinomics: Characterizing the therapeutically validated kinase space  Academic Article
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  • L-a virus at 3.4 Å resolution reveals particle architecture and mrna decapping mechanism  Academic Article
  • Lack of complex i activity in human cells carrying a mutation in mtdna-encoded nd4 subunit is corrected by the saccharomyces cerevisiae nadh-quinone oxidoreductase (ndi1) gene  Academic Article
  • Lactose binding induces opposing dynamics changes in human galectins revealed by NMR-based hydrogen-deuterium exchange  Academic Article
  • Large conformational changes in the maturation of a simple rna virus, nudaurelia capensis omega virus (n omega v)  Academic Article
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  • Leu5enkephalin-encoding sequences are targets for a specific DNA-binding factor.  Academic Article
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  • Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues  Academic Article
  • Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening  Academic Article
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  • Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor  Academic Article
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  • Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms  Academic Article
  • Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate  Academic Article
  • Like-acetylglucosaminyltransferase (large)-dependent modification of dystroglycan at thr-317/319 is required for laminin binding and arenavirus infection  Academic Article
  • Linear and cyclic N-terminal galanin fragments and analogs as ligands at the hypothalamic galanin receptor  Academic Article
  • Linear combinations of docking affinities explain quantitative differences in RTK signaling  Academic Article
  • Linking folding and binding  Academic Article
  • Lipid binding promotes oligomerization and focal adhesion activity of vinculin  Academic Article
  • Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells - regulation by egr-1, c-jun, and nf-kappa b transcription factors  Academic Article
  • Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2  Academic Article
  • Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in thp-1 monocytic cells requires both activator protein-1 and nuclear factor-kappa-b binding-sites  Academic Article
  • Lipoprotein complex of equine lysozyme with oleic acid (eloa) interactions with the plasma membrane of live cells  Academic Article
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  • Local folding coupled to RNA binding in the yeast ribosomal protein L30  Academic Article
  • Localization of carbohydrate attachment sites and disulfide bridges in limulus alpha(2)-macroglobulin - evidence for two forms differing primarily in their bait region sequences  Academic Article
  • Localization of membrane permeabilization and receptor binding sites on the vp4 hemagglutinin of rotavirus: Implications for cell entry  Academic Article
  • Localization of sites of interaction between p23 and hsp90 in solution  Academic Article
  • Localization of the binding-site for the human high-affinity fc receptor on igg  Academic Article
  • Localization of the heme binding region in soluble guanylate cyclase  Academic Article
  • Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity  Academic Article
  • Location of high-affinity metal-binding sites in the profile structure of the Ca+2-ATPase in the sarcoplasmic-reticulum by resonance x-ray-diffraction  Academic Article
  • Location of the saccharide binding site of concanavalin a  Academic Article
  • Location, degree, and direction of DNA bending associated with the Hin recombinational enhancer sequence and Fis-enhancer complex  Academic Article
  • Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase  Academic Article
  • Lung Kruppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase  Academic Article
  • Lysis of human cultured lymphoblastoid cells by cell-induced activation of properdin pathway  Academic Article
  • M-15: high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus, and spinal cord  Academic Article
  • MDB: The metalloprotein database and browser at The Scripps Research Institute  Academic Article
  • Mafa has strong cell transforming ability but is a weak transactivator  Academic Article
  • Magnetic-properties of cobalt substituted bovine superoxide-dismutase derivatives  Academic Article
  • Maintaining genetic code through adaptations of tRNA synthetases to taxonomic domains  Academic Article
  • Major anticodon-binding region missing from an archaebacterial tRNA synthetase  Academic Article
  • Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape  Academic Article
  • Malachite green mediates homodimerization of antibody VL domains to form a fluorescent ternary complex with singular symmetric interfaces  Academic Article
  • Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation  Academic Article
  • Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity  Academic Article
  • Manipulation of thrombin exosite I, by ligand-directed covalent modification  Academic Article
  • Map2 and tau bind longitudinally along the outer ridges of microtubule protofilaments  Academic Article
  • Map2c, but not tau, binds via its microtubule binding and bundles f-actin domain  Academic Article
  • Mapkk-independent activation of p38 alpha mediated by tab1-dependent autophosphorylation of p38 alpha  Academic Article
  • Mapping a common interaction site used by plasmodium falciparum duffy binding-like domains to bind diverse host receptors  Academic Article
  • Mapping binding residues in the Plasmodium vivax domain that binds Duffy antigen during red cell invasion  Academic Article
  • Mapping determinants of the substrate selectivities of P450 enzymes by site-directed mutagenesis  Academic Article
  • Mapping enzyme active sites in complex proteomes  Academic Article
  • Mapping interactions between the rna chaperone fino and its rna targets  Academic Article
  • Mapping of distinct von Willebrand factor domains interacting with platelet GPIb and GPIIb/IIIa and with collagen using monoclonal antibodies  Academic Article
  • Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, hpr and iia(glc)  Academic Article
  • Mapping of the cxcr4 binding site within variable region 3 of the feline immunodeficiency virus surface glycoprotein  Academic Article
  • Mapping the binding site of BMS-708163 on γ-secretase with cleavable photoprobes  Academic Article
  • Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo  Academic Article
  • Mapping the interactions of the p53 transactivation domain with the kix domain of cbp  Academic Article
  • Mapping the transition state of the WW domain beta-sheet  Academic Article
  • Maxamycins: Durable Antibiotics Derived by Rational Redesign of Vancomycin  Academic Article
  • Measles virus recognizes its receptor, cd46, via two distinct binding domains within scr1-2  Academic Article
  • Measles-virus and c3 binding-sites are distinct on membrane cofactor protein (cd46)  Academic Article
  • Mechanism and atomic structure of superoxide dismutase  Academic Article
  • Mechanism of Action of an Imidopiperidine Inhibitor of Human Polynucleotide Kinase/Phosphatase  Academic Article
  • Mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia: Role of the nucleotide positioning loop  Academic Article
  • Mechanism of binding site conformational switching in the CD44-hyaluronan protein-carbohydrate binding interaction  Academic Article
  • Mechanism of drug inhibition and drug resistance of influenza A M2 channel  Academic Article
  • Mechanism of human alpha-1,3-fucosyltransferase v: Glycosidic cleavage occurs prior to nucleophilic attack  Academic Article
  • Mechanism of microtubule stabilization by doublecortin  Academic Article
  • Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01  Academic Article
  • Mechanism of thioflavin T binding to amyloid fibrils  Academic Article
  • Mechanism-based phage display selection of active-site mutants of human glutathione transferase A1-1 catalyzing SNAr reactions  Academic Article
  • Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate  Academic Article
  • Mechanisms of spectral tuning in blue cone visual pigments. Visible and raman spectroscopy of blue-shifted rhodopsin mutants  Academic Article
  • Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides  Academic Article
  • Mechanistic implications of pseudo zero order kinetics in kinetic resolutions  Academic Article
  • Mechanistic studies of beta-arylsulfotransferase iv  Academic Article
  • Mediator structural conservation and implications for the regulation mechanism  Academic Article
  • Membrane-associated DNA in the cytoplasm of diploid human lymphocytes  Academic Article
  • Merlin, the product of the Nf2 tumor suppressor gene, the p21-activated is an inhibitor of kinase, Pak1  Academic Article
  • Metal stoichiometry and functional studies of the diphtheria toxin repressor  Academic Article
  • Metal-binding site in a class I tRNA synthetase localized to a cysteine cluster inserted into nucleotide-binding fold  Academic Article
  • Metal-binding sites in proteins  Academic Article
  • Metalloantibody design  Academic Article
  • Methionine ligand interaction in a blue copper protein characterized by site-selective infrared spectroscopy  Academic Article
  • Microarray platform for profiling enzyme activities in complex proteomes  Academic Article
  • Microbial glycan microarrays define key features of host-microbial interactions  Academic Article
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  • Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter  Academic Article
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  • Probing the Tetrahymena group I ribozyme reaction in both directions  Academic Article
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  • Probing the structural basis for enzyme-substrate recognition in Cu, Zn superoxide dismutase  Academic Article
  • Probing the substrate specificity and protein-protein interactions of the E. coli fatty acid dehydratase, FabA  Academic Article
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  • Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains  Academic Article
  • Rhombohedral crystals of the human vinculin head domain in complex with a vinculin-binding site of talin  Academic Article
  • Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding  Academic Article
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  • Role of zymogen and activated factor x as scaffolds for the inhibition of the blood coagulation factor viia-tissue factor complex by recombinant nematode anticoagulant protein c2  Academic Article
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  • Rotational correlation time of concanavalin-a after interaction with a fluorescent-probe  Academic Article
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  • Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay  Academic Article
  • Screening transthyretin amyloid fibril inhibitors: Characterization of novel multiprotein, multiligand complexes by mass spectrometry  Academic Article
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  • Selection of apoptotic cell specific human antibodies from adult bone marrow  Academic Article
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  • Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites  Academic Article
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  • Selective chemical catalysis by an antibody  Academic Article
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  • Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP  Academic Article
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  • Spatially directed assembly of a heterotetrameric Cre-Lox synapse restricts recombination specificity  Academic Article
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  • Spontaneous platelet aggregation in type IIB Tampa von Willebrand disease is inhibited by the 52/48-kDa fragment of normal von Willebrand factor, which contains the GPIb binding domain  Academic Article
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  • Strained cyclic disulfides enable cellular uptake by reacting with the transferrin receptor  Academic Article
  • Streptococcal m1 protein constructs a pathological host fibrinogen network  Academic Article
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  • Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains  Academic Article
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  • Structural analysis of caspase-1 inhibitors derived from Tethering  Academic Article
  • Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate  Academic Article
  • Structural analysis of inhibitor binding to human carbonic anhydrase II  Academic Article
  • Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity  Academic Article
  • Structural analysis of papain-like NlpC/p60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites  Academic Article
  • Structural and biochemical characterization of the therapeutic anabaena variabilis phenylalanine ammonia lyase  Academic Article
  • Structural and biophysical characterization of the EphB4.ephrinB2 protein-protein interaction and receptor specificity  Academic Article
  • Structural and functional analysis of the plasminogen activator inhibitor-1 binding motif in the somatomedin B domain of vitronectin  Academic Article
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  • Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6  Academic Article
  • Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome p4502b4  Academic Article
  • Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles  Academic Article
  • Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair  Academic Article
  • Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors  Academic Article
  • Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor  Academic Article
  • Structural basis for amplifying vinculin activation by talin  Academic Article
  • Structural basis for bifunctional peptide recognition at human delta-opioid receptor  Academic Article
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  • Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases  Academic Article
  • Structural basis for endothelial nitric oxide synthase binding to calmodulin  Academic Article
  • Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase  Academic Article
  • Structural basis for hif-1 alpha/cbp recognition in the cellular hypoxic response  Academic Article
  • Structural basis for high-affinity peptide inhibition of human Pin1  Academic Article
  • Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics  Academic Article
  • Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase  Academic Article
  • Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway  Academic Article
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  • Structural basis for recruitment of cbp/p300 coactivators by stat1 and stat2 transactivation domains  Academic Article
  • Structural basis for specific inhibition of tRNA synthetase by an ATP competitive inhibitor  Academic Article
  • Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase  Academic Article
  • Structural basis for the coevolution of a viral RNA-protein complex  Academic Article
  • Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases  Academic Article
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  • Structure of botulinurn neurotoxin type d light chain at 1.65 Å resolution: Repercussions for vamp-2 substrate specificity  Academic Article
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  • Structure of mammalian poly(adp- ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element  Academic Article
  • Structure of microsomal cytochrome p4502b4 complexed with the antifungal drug bifonazole - insight into p450 conformational plasticity and membrane interaction  Academic Article
  • Structure of nitric oxide synthase oxygenase dimer with pterin and substrate  Academic Article
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  • Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex  Academic Article
  • Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone  Academic Article
  • Structure of the DNA repair and replication endonuclease and exonuclease fen-1: Coupling DNA and pcna binding to fen-1 activity  Academic Article
  • Structure of the DNA repair enzyme endonuclease iv and its DNA complex: Double-nucleotide flipping at abasic sites and three-metal-ion catalysis  Academic Article
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  • Structure of the I-1 early intermediate of photoactive yellow protein by FTIR spectroscopy  Academic Article
  • Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding  Academic Article
  • Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain  Academic Article
  • Structure of the actin-myosin complex and its implications for muscle-contraction  Academic Article
  • Structure of the hemagglutinin membrane glycoprotein of influenza-virus at 3-a resolution  Academic Article
  • Structure of the heterodimeric complex between CAD domains of CAD and ICAD  Academic Article
  • Structure of the human ATG12 similar to ATG5 conjugate required for LC3 lipidation in autophagy  Academic Article
  • Structure of the human Dicer-TRBP complex by electron microscopy  Academic Article
  • Structure of the human P2Y(12) receptor in complex with an antithrombotic drug  Academic Article
  • Structure of the human TRPM4 ion channel in a lipid nanodisc  Academic Article
  • Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist  Academic Article
  • Structure of the human epithelial sodium channel by cryo-electron microscopy  Academic Article
  • Structure of the human glucagon class B G-protein-coupled receptor  Academic Article
  • Structure of the human histamine h(1) receptor complex with doxepin  Academic Article
  • Structure of the human smoothened receptor bound to an antitumour agent  Academic Article
  • Structure of the human κ-opioid receptor in complex with JDTic  Academic Article
  • Structure of the influenza-virus hemagglutinin complexed with its receptor, sialic-acid  Academic Article
  • Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity  Academic Article
  • Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic  Academic Article
  • Structure of the nuclear factor aly: Insights into post-transcriptional regulatory and mrna nuclear export processes  Academic Article
  • Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of creb binding protein  Academic Article
  • Structure of the uncleaved human h1 hemagglutinin from the extinct 1918 influenza virus  Academic Article
  • Structure of the von Willebrand factor domain interacting with glycoprotein Ib  Academic Article
  • Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction  Academic Article
  • Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase  Academic Article
  • Structure of transfer RNA-aminoacyl transfer RNA synthetase complexes investigated by nuclease digestion  Academic Article
  • Structure of yeast RNA polymerase II in solution: Implications for enzyme regulation and interaction with promoter DNA  Academic Article
  • Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D28K  Academic Article
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  • Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105  Academic Article
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  • Structure-activity relationships in flexible protein domains: Regulation of Rho GTPases by RhoGDI and D4 GDI  Academic Article
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  • Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids  Academic Article
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  • Structure-based engineering of internal cavities in coiled-coil peptides  Academic Article
  • Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors  Academic Article
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  • Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine  Academic Article
  • Structure-based stabilization of hiv-1 gp120 enhances humoral immune responses to the induced co-receptor binding site  Academic Article
  • Structure-based, targeted deglycosylation of hiv-1 gp120 and effects on neutralization sensitivity and antibody recognition  Academic Article
  • Structure-function relationship of proteins belonging to the family of receptors coupled to gtp-binding proteins  Academic Article
  • Structure-function relationships of platelet glycoprotein Ib as a receptor for von Willebrand factor  Academic Article
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  • Structure/function studies on a S-adenosyl-(L)-methionine-dependent uroporphyrinogen III C methyltransferase (SUMT), a key regulatory enzyme of tetrapyrrole biosynthesis  Academic Article
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  • Structures of the N-omega-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins  Academic Article
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  • Studies of bovine neurophysin-neurohypophyseal hormone interactions  Academic Article
  • Studies of histidine residues of triose phosphate isomerase by proton magnetic-resonance and x-ray crystallography  Academic Article
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  • Studies on reconstitution of bovine erythrocyte superoxide dismutase .3. Evidence for a strong interdependence between cu2+ and zn2+ binding in expression of spectroscopic properties of native protein and for a close proximity of zn2+ and cu2+ sites  Academic Article
  • Studies on reconstitution of bovine erythrocyte superoxide dismutase .4. Preparation and some properties of enzyme in which co(ii) is substituted for zn(ii)  Academic Article
  • Studies on reconstitution of bovine erythrocyte superoxide-dismutase .5. Preparation and properties of derivatives in which both zinc and copper sites contain copper  Academic Article
  • Studies on the mechanism of enzymatic DNA elongation by Escherichia coli DNA polymerase II  Academic Article
  • Studies on the structure of nadh-ubiquinone oxidoreductase complex - topography of the subunits of the iron-sulfur flavoprotein component  Academic Article
  • Study of redox reactions of biological importance between fe(iii) complexes and aromatic moieties  Academic Article
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  • Subdomain chimeras of hepatic lipase and lipoprotein lipase - localization of heparin and cofactor binding  Academic Article
  • Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065  Academic Article
  • Substituting c-jun n-terminal kinase-3 (jnk3) atp-binding site amino acid residues with their p38 counterparts affects binding of jnk- and p38-selective inhibitors  Academic Article
  • Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes  Academic Article
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  • Subtle atomic group discrimination in the RNA minor groove  Academic Article
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  • Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90  Academic Article
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  • The amino-terminus of the human c5a receptor is required for high-affinity c5a binding and for receptor activation by c5a but not c5a analogs  Academic Article
  • The antibody problem  Academic Article
  • The antitumor agent cc-1065 inhibits helicase-catalyzed unwinding of duplex DNA  Academic Article
  • The anxiolytic-like effects of the neurosteroid allopregnanolone: Interactions with gaba(a) receptors  Academic Article
  • The artt motif and a unified structural understanding of substrate recognition in adp-ribosylating bacterial toxins and eukaryotic adp-ribosyltransferases  Academic Article
  • The assignment of an exchangeable low-field NH proton resonance of ribonuclease A to the active-site histidine-119  Academic Article
  • The association of the c7 allotype of rabbits with some light polypeptide chains which lack b locus allotypy  Academic Article
  • The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites  Academic Article
  • The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50  Academic Article
  • The beta-2-adrenergic receptors of human epidermoid carcinoma-cells bear 2 different types of oligosaccharides which influence expression on the cell-surface  Academic Article
  • The binding of substrates and a product of the enzymatic reaction to glutathione S-transferase A  Academic Article
  • The biologic activity of the immunoregulatory lipoprotein, ldl-in, is independent of its free fatty-acid content  Academic Article
  • The c-terminal domain of yeast pcna is required for physical and functional interactions with cdc9 DNA ligase  Academic Article
  • The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition  Academic Article
  • The catalytic site of cytochrome P4504A11 (CYP4A11) and its L131F mutant  Academic Article
  • The cell-binding domains of plasminogen and their function in plasma  Academic Article
  • The chemistry of the antibody molecule  Academic Article
  • The client protein p53 adopts a molten globule-like state in the presence of hsp90  Academic Article
  • The conserved KMN network constitutes the core microtubule-binding site of the kinetochore  Academic Article
  • The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation  Academic Article
  • The cooh terminus of aminoglycoside phosphotransferase (3 ')-iiia is critical for antibiotic recognition and resistance  Academic Article
  • The core meiotic transcriptome in budding yeasts  Academic Article
  • The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase  Academic Article
  • The covalent and three-dimensional structure of concanavalin a  Academic Article
  • The covalent structure of a human gamma G-immunoglobulin. XI. Functional implications  Academic Article
  • The croonian lecture 2000. Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission  Academic Article
  • The crystal structure of a novel bacterial adenylyltransferase reveals half of sites reactivity  Academic Article
  • The crystal structure of avian cd1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian cd1  Academic Article
  • The crystal structure of human Argonaute2  Academic Article
  • The crystal structure of the Helicobacter pylori LlaJI.R1 N-terminal domain provides a model for site-specific DNA binding  Academic Article
  • The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function  Academic Article
  • The crystal structure of the human DNA repair endonuclease hap1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites  Academic Article
  • The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity  Academic Article
  • The crystal structures of chloramphenicol phosphotransferase reveal a novel inactivation mechanism  Academic Article
  • The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism  Academic Article
  • The cytoplasmic tall peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein  Academic Article
  • The delta subunit of AP-3 is required for efficient transport of VSV-G from the trans-Golgi network to the cell surface  Academic Article
  • The design and synthesis of novel alpha-ketoamide-based p38 map kinase inhibitors  Academic Article
  • The dynamic energy landscape of dihydrofolate reductase catalysis  Academic Article
  • The effect of ribosome assembly cofactors on in vitro 30S subunit reconstitution  Academic Article
  • The evi-1 zinc-finger myeloid transforming protein binds to genomic fragments containing (gata)(n) sequences  Academic Article
  • The evolution of cefotaximase activity in the TEM β-lactamase  Academic Article
  • The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro  Academic Article
  • The gal4 activation domain binds sug2 protein, a proteasome component, in vivo and in vitro  Academic Article
  • The geminivirus nuclear shuttle protein is a virulence factor that suppresses transmembrane receptor kinase activity  Academic Article
  • The gene of chicken axonin-1. Complete structure and analysis of the promoter  Academic Article
  • The generation of stable cho-cell lines expressing very high-levels of complement c5a receptors and subsequent modulation of binding-affinity for c5a  Academic Article
  • The growth-promoting activity of the bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3  Academic Article
  • The high activity of rat glutathione transferase 8-8 with alkene substrates is dependent on a glycine residue in the active site  Academic Article
  • The high resolution crystal structure of green abalone sperm lysin: Implications for species-specific binding of the egg receptor  Academic Article
  • The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme  Academic Article
  • The homeobox transcription factor Barx2 regulates chondrogenesis during limb development  Academic Article
  • The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells  Academic Article
  • The human retinoblastoma susceptibility gene promoter is positively autoregulated by its own product  Academic Article
  • The identification of metal-binding ligand residues in metalloproteins using nuclear magnetic resonance spectroscopy  Academic Article
  • The immunological evolution of catalysis  Academic Article
  • The importance of ligand-receptor conformational pairs in stabilization: spotlight on the N/OFQ G protein-coupled receptor  Academic Article
  • The importance of thiol- and disulfide groups in agonist and antagonist binding to the muscarinic receptor  Academic Article
  • The infectivity and host range of the ecotropic porcine endogenous retrovirus, perv-c, is modulated by residues in the c-terminal region of its surface envelope protein  Academic Article
  • The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin  Academic Article
  • The internal ribosome entry site (ires) contained within the rna-binding motif protein 3 (rbm3) mrna is composed of functionally distinct elements  Academic Article
  • The kinetics of nucleated polymerizations at high concentrations: Amyloid fibril formation near and above the "supercritical concentration''  Academic Article
  • The kringle V-protease domain is a fibrinogen binding region within apo(a)  Academic Article
  • The lef-1 high-mobility group domain undergoes a disorder-to-order transition upon formation of a complex with cognate DNA  Academic Article
  • The leu-enkephalin-encoding sequence DNA-binding factor (lef) is the transcription factor yy1  Academic Article
  • The leukocyte cell-surface receptor(s) for the ic3b product of complement  Academic Article
  • The maize (Zea mays L.) nucleoside diphosphate kinase1 (ZmNDPK1) gene encodes a human NM23-H2 homologue that binds and stabilizes G-quadruplex DNA  Academic Article
  • The major nuclear envelope targeting domain of lap2 coincides with its lamin binding region but is distinct from its chromatin interaction domain  Academic Article
  • The making of a phage  Academic Article
  • The modular character of a DNA junction-resolving enzyme - a zinc-binding motif in bacteriophage-T4 endonuclease-VII  Academic Article
  • The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins  Academic Article
  • The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule  Academic Article
  • The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K  Academic Article
  • The molecular perspective: Methotrexate  Academic Article
  • The nadh-binding subunit of the energy-transducing nadh-ubiquinone oxidoreductase of paracoccus-denitrificans - gene cloning and deduced primary structure  Academic Article
  • The nature of the enzymatic reduction of the mixed disulfide of coenzyme A and glutathione  Academic Article
  • The nh2-terminal region of apolipoprotein b is sufficient for lipoprotein association with glycosaminoglycans  Academic Article
  • The nuclear-magnetic-resonance solution structure of the mixed disulfide between escherichia-coli glutaredoxin(c14s) and glutathione  Academic Article
  • The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathway  Academic Article
  • The oncogenic potential of the high mobility group box protein sox3  Academic Article
  • The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger  Academic Article
  • The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs  Academic Article
  • The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster  Academic Article
  • The proton-translocating nadh-quinone oxidoreductase (ndh-1) of thermophilic bacterium thermus thermophilus hb-8 - complete DNA sequence of the gene cluster and thermostable properties of the expressed nq02 subunit  Academic Article
  • The rad50 signature motif: Essential to atp binding and biological function  Academic Article
  • The rad50 zinc-hook is a structure joining mre11 complexes in DNA recombination and repair  Academic Article
  • The recognition of H-2 and viral antigens by cytotoxic T cells  Academic Article
  • The reduced, denatured somatomedin B domain of vitronectin refolds into a stable, biologically active molecule  Academic Article
  • The regulatory regions of the rice tungro bacilliform virus promoter and interacting nuclear factors in rice (Oryza sativa L.)  Academic Article
  • The relationship between structure and function for the sulfite reductases  Academic Article
  • The retinoblastoma susceptibility gene-product represses transcription when directly bound to the promoter  Academic Article
  • The rice phytochrome gene: structure, autoregulated expression, and binding of GT-1 to a conserved site in the 5' upstream region  Academic Article
  • The role of arginine-143 in the electrostatics and mechanism of Cu,Zn superoxide-dismutase - computational and experimental evaluation by mutational analysis  Academic Article
  • The role of dynamic conformational ensembles in biomolecular recognition  Academic Article
  • The roles of S1 RNA-binding domains in Rrp5's interactions with pre-rRNA  Academic Article
  • The second receptor binding site of the globular head of the newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion  Academic Article
  • The self-inhibited structure of full-length PCSK9 at 1.9 Å reveals structural homology with resistin within the C-terminal domain  Academic Article
  • The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope  Academic Article
  • The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle  Academic Article
  • The sialyltransferase sialylmotif participates in binding the donor substrate cmp-neuac  Academic Article
  • The sigma(1) (sigma(1)) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming  Academic Article
  • The small nuclear ribonucleoprotein SS-B/La binds RNA with a conserved protease-resistant domain of 28 kilodaltons  Academic Article
  • The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML  Academic Article
  • The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor  Academic Article
  • The structural basis for biphasic kinetics in the folding of the WW domain from a formin-binding protein: lessons for protein design?  Academic Article
  • The structural basis for in situ activation of DNA alkylation by duocarmycin sa  Academic Article
  • The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae  Academic Article
  • The structural basis of recognition and removal of cellular mrna 7-methyl g 'caps' by a viral capsid protein: A unique viral response to host defense  Academic Article
  • The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability  Academic Article
  • The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type iiptrases  Academic Article
  • The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0 Å resolution  Academic Article
  • The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05 Å resolution  Academic Article
  • The structure of jnk3 in complex with small molecule inhibitors: Structural basis for potency and selectivity  Academic Article
  • The structure of nitric oxide synthase oxygenase domain and inhibitor complexes  Academic Article
  • The structure of the crispr-associated protein csa3 provides insight into the regulation of the crispr/cas system  Academic Article
  • The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex  Academic Article
  • The structure of the yeast nadh dehydrogenase (ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates  Academic Article
  • The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif  Academic Article
  • The tau-4 activation domain of the thyroid-hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing  Academic Article
  • The theoretical limits of DNA sequence discrimination by linked polyamides  Academic Article
  • The thermotoga maritima trk potassium transporter-from frameshift to function  Academic Article
  • The third Trp-Lys-Ser (WKS) tripeptide motif in tissue factor is associated with a function site  Academic Article
  • The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli  Academic Article
  • The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis  Academic Article
  • The transcriptional control of the perforin locus  Academic Article
  • The transition-state regulator hpr of bacillus-subtilis is a DNA-binding protein  Academic Article
  • The transition-state transcription regulator abrb of bacillus-subtilis is a DNA-binding protein  Academic Article
  • The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire  Academic Article
  • The usher syndrome proteins cadherin 23 and harmonin form a complex by means of pdz-domain interactions  Academic Article
  • The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin  Academic Article
  • The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments  Academic Article
  • The way things move: Looking under the hood of molecular motor proteins  Academic Article
  • Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin  Academic Article
  • Thermodynamic analysis of purified human placental alpha-l-fucosidase  Academic Article
  • Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase  Academic Article
  • Thermodynamics of RNA-RNA duplexes with 2-or 4-thiouridines: implications for antisense design and targeting a group I intron  Academic Article
  • Thiol ligation of two zinc atoms to a class I tRNA synthetase: evidence for unshared thiols and role in amino acid binding and utilization  Academic Article
  • Thioredoxin catalyzes the s-nitrosation of the caspase-3 active site cysteine  Academic Article
  • Three pairs of cysteine residues mediate both redox and Zn2+ modulation of the NMDA receptor  Academic Article
  • Three photo-cross-linked complexes of yeast phenylalanine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases  Academic Article
  • Three-dimensional EM structure of the ectodomain of integrin alpha V beta 3 in a complex with fibronectin  Academic Article
  • Three-dimensional location of the main immunogenic region of the acetylcholine receptor  Academic Article
  • Three-dimensional model of membrane-bound ribosomes obtained by electron microscopy  Academic Article
  • Three-dimensional model of the human platelet integrin alpha(llb)beta(3) based on electron cryomicroscopy and x-ray crystallography  Academic Article
  • Three-dimensional solution structure of a single zinc finger DNA-binding domain  Academic Article
  • Three-dimensional solution structure of the reduced form of Escherichia coli thioredoxin determined by nuclear magnetic resonance spectroscopy  Academic Article
  • Three-dimensional structure of brush border myosin-i at similar to 20 Å resolution by electron microscopy and image analysis  Academic Article
  • Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin  Academic Article
  • Tissue factor - molecular recognition and cofactor function  Academic Article
  • Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity  Academic Article
  • Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta(3) subunit  Academic Article
  • Topography of the high-affinity lysine binding site of plasminogen as defined with a specific antibody probe  Academic Article
  • Total syntheses and initial evaluation of [?[C(-S)NH]Tpg(4)]vancomycin, [?[C(-NH)NH]Tpg(4)]vancomycin, [?[CH2NH]Tpg(4)]vancomycin, and their (4-Chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptide antibiotics  Academic Article
  • Total synthesis of Psi C(=NH)NH Tpg(4) vancomycin and its ((4)-chlorobiphenyl)methyl derivative: impact of peripheral modifications on vancomycin analogues redesigned for dual D-Ala-D-Ala and D-Ala-D-Lac binding  Academic Article
  • Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5 '-gnn-3 ' DNA target sequences  Academic Article
  • Toward understanding the structural basis of partial agonism at the dopamine D-3 receptor  Academic Article
  • Transcript leader regions of two saccharomyces cerevisiae mrnas contain internal ribosome entry sites that function in living cells  Academic Article
  • Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)to-DJ(H) rearrangement of immunoglobulin genes  Academic Article
  • Transcription inactivation through local refolding of the RNA polymerase structure  Academic Article
  • Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9  Academic Article
  • Transcriptional regulation of BCL-2 by nuclear factor kappa B and its significance in prostate cancer  Academic Article
  • Transcriptional regulation of the mouse fatty acid amide hydrolase gene  Academic Article
  • Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis  Academic Article
  • Transfer RNA: from minihelix to genetic code  Academic Article
  • Transfer of flexibility between ankyrin repeats in i kappa b alpha upon formation of the nf-kappa b complex  Academic Article
  • Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase  Academic Article
  • Trapping and characterization of novel retinoid response elements  Academic Article
  • Trapping the dynamic acyl carrier protein in fatty acid biosynthesis  Academic Article
  • Trial for peptide bond formation using model molecules based on the interactions between the CCA sequence of tRNA and 23S rRNA  Academic Article
  • Tropomodulin binds to filensin intermediate filaments  Academic Article
  • Tropomodulin contains two actin filament pointed end-capping domains  Academic Article
  • Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin  Academic Article
  • Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein  Academic Article
  • Two classes of binding sites for uncoating protein in clathrin triskelions  Academic Article
  • Two classes of cholesterol binding sites for the β2AR revealed by thermostability and NMR  Academic Article
  • Two classes of tRNA synthetases suggested by sterically compatible dockings on tRNA acceptor stem  Academic Article
  • Two estrogen receptors in reproductive tissue  Academic Article
  • Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency  Academic Article
  • Two ligands may bind simultaneously to the muscarine receptor  Academic Article
  • Two mutations in the promoter region of the human protein-C gene both cause type-I protein-C deficiency by disruption of 2 HNF-3 binding-sites  Academic Article
  • Two photo-cross-linked complexes of isoleucine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases  Academic Article
  • Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa  Academic Article
  • Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides  Academic Article
  • Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines  Academic Article
  • Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors  Academic Article
  • Type-III omega-agatoxins - a family of probes for similar binding-sites on L-type and N-type calcium channels  Academic Article
  • Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2 '-deoxyuridine 5 '-monophosphate  Academic Article
  • Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120  Academic Article
  • Uba domains mediate protein-protein interactions between two DNA damage-inducible proteins  Academic Article
  • Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2  Academic Article
  • Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates  Academic Article
  • Ubiquitylation of cyclin e requires the sequential function of scf complexes containing distinct hcdc4 isoforms  Academic Article
  • Understanding the enzymatic activity of 4-oxalocrotonate tautomerase and its mutant analogues: A computational study  Academic Article
  • Understanding the recognition of transfer RNAs by aminoacyl transfer RNA synthetases  Academic Article
  • Unexpected acetylcholinesterase activity of cocaine esterases  Academic Article
  • Unexpected ca2+-binding properties of synaptotagmin 9  Academic Article
  • Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase  Academic Article
  • Unique interactions of asialo von Willebrand factor with platelets in platelet-type von Willebrand disease  Academic Article
  • Unmasking of CD22 co-receptor on germinal center B-cells occurs by alternative mechanisms in mouse and man  Academic Article
  • Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease iv  Academic Article
  • Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein lb  Academic Article
  • Upstream activation sequence-dependent alteration of chromatin structure and transcription activation of the yeast GAL1-GAL10 genes  Academic Article
  • Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects  Academic Article
  • Use of phage display and transition-state analogs to select enzyme variants with altered catalytic properties: Glutathione transferase as an example  Academic Article
  • Use of sialic-acid analogs to define functional-groups involved in binding to the influenza-virus hemagglutinin  Academic Article
  • Using AutoDock for ligand-receptor docking  Academic Article
  • Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task  Academic Article
  • Using the process of reactive immunization to induce catalytic antibodies with complex mechanisms: Aldolases  Academic Article
  • Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: Murine alpha 8 beta 1 binds to the rgd site in tenascin-c fragments, but not to native tenascin-c  Academic Article
  • V-jun encodes a nuclear protein with enhancer binding properties of ap-1  Academic Article
  • Vaccine elicitation of high mannose-dependent neutralizing antibodies against the V3-glycan broadly neutralizing epitope in nonhuman primates  Academic Article
  • Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign  Academic Article
  • Vaccine-elicited tier 2 HIV-1 neutralizing antibodies bind to quaternary epitopes involving glycan-deficient patches proximal to the CD4 binding site  Academic Article
  • Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention  Academic Article
  • Variable loop glycan dependency of the broad and potent hiv-1-neutralizing antibodies pg9 and pg16  Academic Article
  • Variation and control of specific antigen-binding cell-populations in individual fetal mice  Academic Article
  • Vinculin binding in its closed conformation by a helix addition mechanism  Academic Article
  • Virtual screening against acetylcholine binding protein  Academic Article
  • Virtual screening against alpha-cobratoxin  Academic Article
  • Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors  Academic Article
  • Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challenge  Academic Article
  • Virus yoga: The role of flexibility in virus host cell recognition  Academic Article
  • Virus-induced immune complex disease: specific anti-viral antibody and C1q binding material in the circulation during persistent lymphocytic choriomeningitis virus infection  Academic Article
  • Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide  Academic Article
  • Voronoi binding site model of a polycyclic aromatic hydrocarbon binding protein  Academic Article
  • Water-soluble, recombinant cu-a-domain of the cytochrome ba(3) subunit ii from thermus thermophilus  Academic Article
  • What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?  Academic Article
  • White matter NMDA receptors: an unexpected new therapeutic target?  Academic Article
  • Wrn exonuclease structure and molecular mechanism imply an editing role in DNA end processing  Academic Article
  • X-pro peptide-bond as an NMR probe for conformational studies of flexible linear peptides  Academic Article
  • X-ray absorption studies of the Zn2+ site of glyoxalase I  Academic Article
  • X-ray absorption studies of the copper-beta domain of rat-liver metallothionein  Academic Article
  • X-ray crystallographic determination of the structure of the influenza c virus haemagglutinin-esterase-fusion glycoprotein  Academic Article
  • X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus  Academic Article
  • X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease  Academic Article
  • X-ray structure of junctional adhesion molecule: Structural basis for homophilic adhesion via a novel dimerization motif  Academic Article
  • X-ray structure of metallothionein  Academic Article
  • X-ray structures of the LXRα LBD in its homodimeric form and implications for heterodimer signaling  Academic Article
  • Xyloglucan sidechains modulate binding to cellulose during in vitro binding assays as predicted by conformational dynamics simulations  Academic Article
  • Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway  Academic Article
  • Yeast glyoxalase I is a monomeric enzyme with two active sites  Academic Article
  • Yy1 binding to a subset of p53 DNA-target sites regulates p53-dependent transcription  Academic Article
  • ZiF-Predict: a web tool for predicting DNA-binding specificity in C2H2 zinc finger proteins  Academic Article
  • Zinc finger tools: Custom DNA-binding domains for transcription factors and nucleases  Academic Article
  • Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology  Academic Article
  • Zinc-dependent cell growth conferred by mutant tRNA synthetase  Academic Article
  • Zinc-dependent tRNA binding by a peptide element within a tRNA synthetase  Academic Article
  • Zinc-free and reduced t4 gene-32 protein binds single-stranded-DNA weakly and fails to stimulate uvsx-catalyzed homologous pairing  Academic Article
  • Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB  Academic Article
  • hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene  Academic Article
  • p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses  Academic Article
  • von Willebrand factor has more than one binding site for platelets  Academic Article
  • von Willebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism  Academic Article
  • γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin  Academic Article

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