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beta-N-Acetylhexosaminidases

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  • A glycoengineered enzyme with multiple mannose-6-phosphates is internalized into diseased cells to restore its activity in lysosomes  Academic Article
  • A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity  Academic Article
  • A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo  Academic Article
  • A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells  Academic Article
  • Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise  Academic Article
  • Development of GlcNAc-Inspired Iminocyclitiols as Potent and Selective N-Acetyl-beta-Hexosaminidase Inhibitors  Academic Article
  • Elevation of global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis  Academic Article
  • Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase  Academic Article
  • Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase  Academic Article
  • Hepatic glucose sensing via the CREB coactivator CRTC2  Academic Article
  • Identification of Asp(174) and Asp(175) as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants  Academic Article
  • Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes  Academic Article
  • Lysosomal glycosphingolipid recognition by NKT cells  Academic Article
  • Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: New structures for antivirals and osteoarthritis  Academic Article
  • O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors  Academic Article
  • Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships  Academic Article
  • Profile of glycosaminoglycan-degrading glycosidases and glycoside sulfatases secreted by human articular chondrocytes in homeostasis and inflammation  Academic Article
  • Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease  Academic Article
  • Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity  Academic Article
  • Synthesis and high-throughput screening of N-acetyl-β-hexosaminidase inhibitor libraries targeting osteoarthritis  Academic Article

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