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- A glycoengineered enzyme with multiple mannose-6-phosphates is internalized into diseased cells to restore its activity in lysosomes Academic Article
- A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity Academic Article
- A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo Academic Article
- A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells Academic Article
- Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise Academic Article
- Development of GlcNAc-Inspired Iminocyclitiols as Potent and Selective N-Acetyl-beta-Hexosaminidase Inhibitors Academic Article
- Elevation of global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis Academic Article
- Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase Academic Article
- Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase Academic Article
- Hepatic glucose sensing via the CREB coactivator CRTC2 Academic Article
- Identification of Asp(174) and Asp(175) as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants Academic Article
- Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes Academic Article
- Lysosomal glycosphingolipid recognition by NKT cells Academic Article
- Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: New structures for antivirals and osteoarthritis Academic Article
- O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors Academic Article
- Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships Academic Article
- Profile of glycosaminoglycan-degrading glycosidases and glycoside sulfatases secreted by human articular chondrocytes in homeostasis and inflammation Academic Article
- Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease Academic Article
- Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity Academic Article
- Synthesis and high-throughput screening of N-acetyl-β-hexosaminidase inhibitor libraries targeting osteoarthritis Academic Article