subject area of
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- A general method for greatly improving the affinity of antibodies by using combinatorial libraries Academic Article
- A general method for site-specific incorporation of unnatural amino acids into proteins Academic Article
- A genetic marker in the variable region of light chains of mouse immunoglobulins Academic Article
- A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes Academic Article
- A genetically encoded fluorescent amino acid Academic Article
- A genetically encoded fluorescent amino acid Academic Article
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- A highly enantioselective route to either enantiomer of both alpha- and beta-amino acid derivatives Academic Article
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- A tryptophanyl-tRNA synthetase/tRNA pair for unnatural amino acid mutagenesis in E. coli Academic Article
- A versatile platform for single- and multiple-unnatural amino acid mutagenesis in Escherichia coli Academic Article
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- Adding new chemistries to the genetic code Academic Article
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- Amino acid dependent formation of phosphate anhydrides in water mediated by carbonyl sulfide Academic Article
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- Amino acid substitution at the dimeric interface of human manganese superoxide dismutase Academic Article
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- Aminoacyl-S-enzyme intermediates in β-hydroxylations and α,β-desaturations of amino acids in peptide antibiotics Academic Article
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- An efficient system for the evolution of aminoacyl-tRNA synthetase specificity Academic Article
- An enhanced system for unnatural amino acid mutagenesis in E. coli Academic Article
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- An expanded genetic code with a functional quadruplet codon Academic Article
- An expanding genetic code Academic Article
- An expanding genetic code Academic Article
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- An experimental approach to evaluating the role of backbone interactions in proteins using unnatural amino acid mutagenesis Academic Article
- An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae Academic Article
- An investigation of specific interactions of deoxyribonucleic acid and lysine-rich (F1) histone preparations Academic Article
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- An α/β-peptide helix bundle with a pure β3-amino acid core and a distinctive quaternary structure Academic Article
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- Antibody conjugates with unnatural amino acids Academic Article
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- Assignment of the h-1 nuclear magnetic-resonance spectrum of the trypsin-inhibitor homologue-k from dendroaspis-polylepis-polylepis - 2 dimensional nuclear magnetic-resonance at 360 and 500 mhz Academic Article
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- Asymmetric synthesis β-hydroxy amino acids via aldol reactions catalyzed by chiral ammonium salts Academic Article
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- Autoantibodies to the presumptive cytoplasmic domain of platelet glycoprotein IIIa in patients with chronic immune thrombocytopenic purpura Academic Article
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- Betidamino acid scan of the gnrh antagonist acyline Academic Article
- Beyond the canonical 20 amino acids: expanding the genetic lexicon Academic Article
- Binding and functional properties of concanavalin-a and its derivatives .2. Proteolytic product with saccharide-binding activity Academic Article
- Binding of β4γ5 by adenosine A1 and A2A receptors determined by stable isotope labeling with amino acids in cell culture and mass spectrometry Academic Article
- Biochemical characterization of the Caenorhabditis elegans FBF. CPB-1 translational regulation complex identifies conserved protein interaction hotspots Academic Article
- Biochemical comparison of lens crystallins from three reptilian species Academic Article
- Biological applications of expanded genetic codes Academic Article
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- Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway Academic Article
- Biosynthetic method for introducing unnatural amino acids site-specifically into proteins Academic Article
- Biosynthetic n-15 and c-13 isotope labeling of glutathione in the mixed disulfide with escherichia-coli glutaredoxin documented by sequence-specific NMR assignments Academic Article
- Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin Academic Article
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- Characterization of glyoxalase I purified from pig erythrocytes by affinity chromatography Academic Article
- Characterization of renal amyloid derived from the variable region of the lambda light chain subgroup-II Academic Article
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- Characterization of the aminocarboxycyclopropane-forming enzyme CmaC Academic Article
- Characterization of the covalent binding of thiostrepton to a thiostrepton-induced protein from streptomyces lividans Academic Article
- Characterization of zebrafish caspase-3 and induction of apoptosis through ceramide generation in fish fathead minnow tailbud cells and zebrafish embryo Academic Article
- Chemical and immunochemical characterization of electrophoretic subfractions of rabbit gammag-immunoglobulin light chains with b4 allotypic specificity Academic Article
- Chemical and immunochemical evidence for different classes of rabbit light polypeptide chains Academic Article
- Chemical approaches for the detection and synthesis of acetylated proteins Academic Article
- Chemical characterization of a neural cell-adhesion molecule purified from embryonic brain membranes Academic Article
- Chemical circuitry and central cardiovascular regulation Academic Article
- Chemical markers of transplantation individuality solubilized with sonic energy Academic Article
- Chemical modification of viruses and virus-like particles Academic Article
- Chemical synthesis of a glycoprotein having an intact human complex-type sialyloligosaccharide under the Boc and Fmoc synthetic strategies Academic Article
- Chemistry of periodate-mediated cross-linking of 3,4-dihydroxylphenylalanine-containing molecules to proteins Academic Article
- Chiral lipid bilayers are enantioselectively permeable Academic Article
- Chiral-selective aminoacylation of an RNA minihelix Academic Article
- Chiral-selective aminoacylation of an RNA minihelix: mechanistic features and chiral suppression Academic Article
- Chlamydia species-dependent differences in the growth requirement for lysosomes Academic Article
- Cholinergic mechanisms in the reticular control of transmission in the cat lateral geniculate-nucleus Academic Article
- Chronic exposure to alcohol during development alters the responses to excitatory amino-acids in cultured Purkinje neurons Academic Article
- Cluster analysis of aminoacyl-tRNAs from mouse plasmacytomas correlates chromatographic profiles with myeloma protein similarity, clonal origin of tumour lines, and the neoplastic nature of the tissues Academic Article
- Combined functional and immunochemical analysis of normal and abnormal human factor-x Academic Article
- Comparison of glyoxalase I purified from yeast (Saccharomyces cerevisiae) with the enzyme from mammalian sources Academic Article
- Complementary use of chemical modification and site-directed mutagenesis to probe structure activity relationships in enzymes Academic Article
- Computational design of an unnatural amino acid dependent metalloprotein with atomic level accuracy Academic Article
- Computational design of multinuclear metalloproteins using unnatural amino acids Academic Article
- Computational prediction of N-linked glycosylation incorporating structural properties and patterns Academic Article
- Conditional lethal mutants of avian sarcoma viruses. Ii. Analysis of the temperature-sensitive lesion in ts 75 Academic Article
- Conformation of the carboxy-terminal region of the a-alpha chain of fibrinogen as elucidated by immunochemical analyses Academic Article
- Conformational sampling by NMR solution structures calculated with the program diana evaluated by comparison with long-time molecular dynamics calculations in explicit water Academic Article
- Conserved amino acid residues of the NuoD segment important for structure and function of Escherichia coli NDH-1 (complex I) Academic Article
- Contribution of aromatic interactions to alpha-helix stability Academic Article
- Contribution of charged amino acids in the CDR2 region of CD4 to HIV-1 gp120 binding Academic Article
- Contribution of five amino acid residues in the glutathione-binding site to the function of human glutathione transferase P1-1 Academic Article
- Controlling amyloid beta-peptide fibril formation with protease-stable ligands Academic Article
- Controlling the architecture, coordination, and reactivity of nanoparticle coating utilizing an amino acid central scaffold Academic Article
- Correlations between internal mobility and stability of globular-proteins Academic Article
- Covalent and 3-dimensional structure of concanavalin-a .1. Amino-acid sequence of cyanogen-bromide fragments f1 and f2 Academic Article
- Covalent and 3-dimensional structure of concanavalin-a .2. Amino-acid sequence of cyanogen-bromide fragment f3 Academic Article
- Cryopreservation of postnatal rat retinal ganglion cells: persistence of voltage- and ligand-gated ionic currents Academic Article
- Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis Academic Article
- Crystallization of a small fragment of an aminoacyl tRNA synthetase Academic Article
- Crystallographic and biochemical analysis of cocaine-degrading antibody l5a10 Academic Article
- Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery Academic Article
- Cytochrome-oxidase genes from thermus-thermophilus - nucleotide-sequence and analysis of the deduced primary structure of subunit-iic of cytochrome-caa3 Academic Article
- Degradable conjugates from oxanorbornadiene reagents Academic Article
- Designing sequence to control protein function in an EF-hand protein Academic Article
- Detecting individual sites subject to episodic diversifying selection Academic Article
- Determination of the nuclear-magnetic-resonance solution structure of the DNA-binding domain (residues 1 to 69) of the 434 repressor and comparison with the x-ray crystal-structure Academic Article
- Developing ligands for palladium(II)-catalyzed C-H functionalization: intimate dialogue between ligand and substrate Academic Article
- Development and optimization of Glaser-Hay bioconjugations Academic Article
- Development of a simple method for protein conjugation by copper-free click reaction and its application to antibody-free Western blot analysis Academic Article
- Development of improved tRNAs for in vitro biosynthesis of proteins containing unnatural amino acids Academic Article
- Development of new enzymatic catalysts for peptide-synthesis in aqueous and organic-solvents Academic Article
- Development of selective tight-binding inhibitors of leukotriene-a4 hydrolase Academic Article
- Developmental expression of excitatory amino-acid responses in cerebellar Purkinje neurons in culture Academic Article
- Developmentally regulated proteins of plasma-membrane of dictyostelium-discoideum - carbohydrate-binding protein Academic Article
- Differences in the amino acid compositions of allogeneic guinea pig transplantation antigens Academic Article
- Dipole moments in relation to configuration of polypeptide chains Academic Article
- Direct amino acid-catalyzed asymmetric desymmetrization of meso-compounds: Tandem aminoxylation/o-n bond heterolysis reactions Academic Article
- Direct asymmetric anti-mannich-type reactions catalyzed by a designed amino acid Academic Article
- Direct organocatalytic asymmetric aldol reactions of alpha-amino aldehydes: Expedient syntheses of highly enantiomerically enriched anti-beta-hydroxy-alpha-amino acids Academic Article
- Direct organocatalytic asymmetric heterodomino reactions: The knoevenagel/diels-alder/epimerization sequence for the highly diastereoselective synthesis of symmetrical and nonsymmetrical synthons of benzoannelated centropolyquinanes Academic Article
- Direct protein-protein conjugation by genetically introducing bioorthogonal functional groups into proteins Academic Article
- Directed evolution of d-sialic acid aldolase to l-3-deoxy-manno-2-octulosonic acid (l-kdo) aldolase Academic Article
- Disparate proteome reactivity profiles of carbon electrophiles Academic Article
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- Diverging catalytic capacities and selectivity profiles with haloalkane substrates of chimeric alpha class glutathione transferases Academic Article
- Diverse functional evolution of serine decarboxylases: identification of two novel acetaldehyde synthases that uses hydrophobic amino acids as substrates Academic Article
- Diversity of light chain variable region sequences among rabbit antibodies elicited by same antigens Academic Article
- Dynamic synaptic communication - finding vocabulary Academic Article
- Dynamics of aromatic amino-acid residues in globular conformation of basic pancreatic trypsin-inhibitor (bpti) .1. H-1 NMR-studies Academic Article
- Dynamics of aromatic amino-acid residues in globular conformation of basic pancreatic trypsin-inhibitor (bpti) .2. Semiempirical energy calculations Academic Article
- Effect of single and repeated methamphetamine treatment on neurotransmitter release in substantia nigra and neostriatum of the rat Academic Article
- Effects of mutations on the partitioning of DNA substrates between the polymerase and 3 '-5 ' exonuclease sites of DNA polymerase i (klenow fragment) Academic Article
- Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence Academic Article
- Efficient access to highly pure β-amyloid peptide by optimized solid-phase synthesis Academic Article
- Efficient and site-specific antibody labeling by strain-promoted azide-alkyne cycloaddition Academic Article
- Efficient incorporation of unnatural amino acids into proteins in Escherichia coli Academic Article
- Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells Academic Article
- Electrostatic contributions to protein-protein interactions: Fast energetic filters for docking and their physical basis Academic Article
- Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma Academic Article
- Emergence of a single solid chiral state from a nearly racemic amino acid derivative Academic Article
- Emergence of solution-phase homochirality via crystal engineering of amino acids Academic Article
- Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair Academic Article
- Enhanced sensitivity to attenuation of conditioned reinstatement by the mGluR 2/3 agonist LY379268 and increased functional activity of mGluR 2/3 in rats with a history of ethanol dependence Academic Article
- Envelope: Interactive software for modeling and fitting complex isotope distributions Academic Article
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- Ether-directed ortho-c-h olefination with a palladium(ii)/monoprotected amino acid catalyst Academic Article
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- Evolution of amber suppressor tRNAs for efficient bacterial production of proteins containing nonnatural amino acids Academic Article
- Evolution of cyclic peptide protease inhibitors Academic Article
- Evolution of multiple, mutually orthogonal prolyl-tRNA synthetase/tRNA pairs for unnatural amino acid mutagenesis in Escherichia coli Academic Article
- Evolution of solid phase homochirality for a proteinogenic amino acid Academic Article
- Excess of rare amino acid polymorphisms in the toll-like receptor 4 in humans Academic Article
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- Exiting an RNA world Academic Article
- Explicit water near the catalytic I helix Thr in the predicted solution structure of CYP2A4 Academic Article
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- Expression and characterization of the flavoprotein subcomplex composed of 50-kda (nqo1) and 25-kda (nqo2) subunits of the proton-translocating nadh-quinone oxidoreductase of paracoccus denitrificans Academic Article
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- Further characterization of human erythrocyte superoxide-dismutase Academic Article
- Gamma heavy-chain disease in man - synthesis of a deleted gamma-3 immunoglobulin by lymphoid-cells in short and long-term tissue-culture Academic Article
- Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness Academic Article
- Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells Academic Article
- Genetic incorporation of recycled unnatural amino acids Academic Article
- Genetic incorporation of unnatural amino acids into proteins in mammalian cells Academic Article
- Genetic introduction of a diketone-containing amino acid into proteins Academic Article
- Genomically recoded organisms expand biological functions Academic Article
- Glutathione S-transferase (transferase pi) from human placenta is identical or closely related to glutathione S-transferase (transferase rho) from erythrocytes Academic Article
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- Highly specific oxidative cross-linking of proteins mediated by a nickel-peptide complex Academic Article
- Human factor XII (Hageman factor) Academic Article
- Human germline antibody gene segments encode polyspecific antibodies Academic Article
- Human glomerular basement membrane. Selective solubilization with chaotropes and chemical and immunologic characterization of its components Academic Article
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- Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus Academic Article
- Identification of amino acid residues important for heparan sulfate proteoglycan interaction within variable region 3 of the feline immunodeficiency virus surface glycoprotein Academic Article
- Identification of amino-acid-residues associated with the 2fe-2s cluster of the 25-kda (nqo2) subunit of the proton-translocating nadh-quinone oxidoreductase of paracoccus-denitrificans Academic Article
- Identification of metal ion binding peptides containing unnatural amino acids by phage display Academic Article
- Identification of novel macrocyclic peptidase substrates via on-bead enzymatic cyclization Academic Article
- Identification of the dicyclohexylcarbodiimide-binding subunit of nadh-ubiquinone oxidoreductase (complex-i) Academic Article
- Identification of the nadh-binding subunit of energy-transducing nadh-quinone oxidoreductase (ndh-1) of thermus thermophilus hb-8 Academic Article
- Identity of tumor necrosis factor and the macrophage-secreted factor cachectin Academic Article
- Imidazolopiperazines: Hit to lead optimization of new antimalarial agents Academic Article
- Immunochemical studies on hen's egg-white lysozyme: Effect of selective nitration of 3 tyrosine residues Academic Article
- Immunologic and biochemical properties of the histamine-sensitizing factor from Bordetella pertussis Academic Article
- Importance of single molecular determinants in the fidelity of expanded genetic codes Academic Article
- Importin beta contains a cooh-terminal nucleoporin binding region important for nuclear transport Academic Article
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- In meso structure of the cobalamin transporter, btub, at 1.95 Å resolution Academic Article
- In vivo photocrosslinking with unnatural amino acid mutagenesis Academic Article
- Incorporation of nonnatural amino acids into proteins Academic Article
- Individual h-1-NMR assignments for the heme groups and the axially bound amino-acids and determination of the coordination geometry at the heme iron in a mixture of 2 isocytochromes-c-551 from rhodopseudomonas-gelatinosa Academic Article
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- Infrared line shape of an alpha-carbon deuterium-labeled amino acid Academic Article
- Inhibition of avian-sarcoma virus replication by glucosamine Academic Article
- Inhibition of lymphocyte protein-synthesis by fibrinogen-derived peptides Academic Article
- Interaction of urea with an unfolded protein - the DNA-binding domain of the 434-repressor Academic Article
- Interactions of bovine neurophysins with neurohypophyseal hormones - role of tyrosine-49 Academic Article
- Introduction of cyclically constrained γ-residues stabilizes an α-peptide hairpin in aqueous solution Academic Article
- Iodopeptides from human thyroglobulin Academic Article
- Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? Academic Article
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- Isolation and characterization of a hemoglobin-derived opioid peptide from the human pituitary-gland Academic Article
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- Isolation and characterization of ribonucleoprotein substructures from Rous sarcoma virus Academic Article
- Isolation and characterization of the nd2 polypeptide of the bovine energy-transducing nadh-ubiquinone oxidoreductase (complex i) Academic Article
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- Isolation and chemical properties of porcine thyrocalcitonin Academic Article
- Isolation and functional-characterization of the active light chain of activated human-blood coagulation factor-XI Academic Article
- Isolation and order of the cyanogen bromide fragments of concanavalin a Academic Article
- Isolation and proteolytic cleavage of the intact subunit of concanavalin a Academic Article
- Key mechanistic features of enantioselective c-h bond activation reactions catalyzed by (chiral mono-n-protected amino acid)-pd(ii) complexes Academic Article
- Kinase consensus sequences: A breeding ground for crosstalk Academic Article
- Kinetic rationalization of nonlinear effects in asymmetric catalysis based on phase behavior Academic Article
- Lactonization as a general route to β-C(sp 3)-H functionalization
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- Molecular basis for the generation in pigs of influenza a viruses with pandemic potential Academic Article
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- Multiple ionic mechanisms are activated by the potent agonist quisqualate in cultured cerebellar Purkinje neurons Academic Article
- Multiple o-glycoforms on the spore coat protein sp96 in dictyostelium discoideum - fuc(alpha 1-3)glcnac-alpha-1-p-ser is the major modification Academic Article
- Multiplex assessment of protein variant abundance by massively parallel sequencing Academic Article
- Multiplex suppression of four quadruplet codons via tRNA directed evolution Academic Article
- Multiscale coarse-graining of the protein energy landscape Academic Article
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