subject area of
- A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: Design, synthesis, and in vitro and in vivo evaluation Academic Article
- A fluoroacetamidine-based inactivator of protein arginine deiminase 4: Design, synthesis, and in vitro and in vivo evaluation Academic Article
- Amidines as amide bond replacements in VLA-4 antagonists Academic Article
- Biophysical and transfection studies of the dic(14)-amidine/DNA complex Academic Article
- Characterization and inactivation of an agmatine deiminase from helicobacter pylori Academic Article
- Cyclic amidine sugars as transition-state analogue inhibitors of glycosidases: Potent competitive inhibitors of mannosidases Academic Article
- Cycloadditions of 1,2,3-triazines bearing C5-electron donating substituents: robust pyrimidine synthesis Academic Article
- Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4 Academic Article
- Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design Academic Article
- Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model Academic Article
- First practical synthesis of formamidine ureas and derivatives Academic Article
- Haloacetamidine-based inactivators of protein arginine deiminase 4 (pad4): Evidence that general acid catalysis promotes efficient inactivation Academic Article
- Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors Academic Article
- Inhibitors and inactivators of protein arginine deiminase 4: Functional and structural characterization Academic Article
- Modelling of Factor Xa-inhibitor complexes: a computational flexible docking approach Academic Article
- N-alpha-benzoyl-n5-(2-chloro-1-iminoethyl)-l-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis Academic Article
- Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition Academic Article
- Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice Academic Article
- Protein arginine deiminase 4: A target for an epigenetic cancer therapy Academic Article
- Rhodium(II)-catalyzed asymmetric sulfur(VI) reduction of diazo sulfonylamidines Academic Article
- Silver(I)-promoted conversion of thioamides to amidines: divergent synthesis of a key series of vancomycin aglycon residue 4 amidines that clarify binding behavior to model ligands Academic Article
- Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors Academic Article
- Synthesis and use of a phosphonate amidine to generate an anti-phosphoarginine-specific antibody Academic Article
- The development of n-alpha-(2-carboxyl)benzoyl-n(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-f-amidine) and n-alpha-(2-carboxyl)benzoyl-n(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-cl-amidine) as second generation protein arginine deiminase (pad) inhibitors Academic Article
- The induction of microrna-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest Academic Article
- Total syntheses of (-)-pyrimidoblamic acid and P-3A Academic Article