subject area of
- 3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts Academic Article
- A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies Academic Article
- A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase Academic Article
- A detergent-activated tyrosinase from xenopus-laevis .1. Purification and partial characterization Academic Article
- A heteroaryldihydropyrimidine activates and can misdirect hepatitis b virus capsid assembly Academic Article
- A metal-binding motif implicated in RNA recognition by an aminoacyl-tRNA synthetase and by a retroviral gene product Academic Article
- A new mechanism of allostery in a G protein-coupled receptor dimer Academic Article
- A novel loop-loop recognition motif in the yeast ribosomal protein L30 autoregulatory RNA complex Academic Article
- A novel α2/α4 subtype-selective positive allosteric modulator of nicotinic acetylcholine receptors acting from the C-tail of an α subunit Academic Article
- A sphingosine 1-phosphate receptor 2 selective allosteric agonist Academic Article
- A steady-state-kinetic model for formaldehyde dehydrogenase from human liver. A mechanism involving NAD+ and the hemimercaptal adduct of glutathione and formaldehyde as substrates and free glutathione as an allosteric activator of the enzyme Academic Article
- ATP sulfurylase from filamentous fungi: which sulfonucleotide is the true allosteric effector? Academic Article
- Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry Academic Article
- Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties Academic Article
- Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis Academic Article
- Allosteric activators of glucokinase: potential role in diabetes therapy Academic Article
- Allosteric communication in the dynein motor domain Academic Article
- Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors Academic Article
- Allosteric control of quaternary states in escherichia-coli aspartate-transcarbamylase Academic Article
- Allosteric inhibition of human ribonucleotide reductase by dATP entails the stabilization of a hexamer Academic Article
- Allosteric inhibition of hypoxia inducible factor-2 with small molecules Academic Article
- Allosteric inhibition via R-state destabilization in ATP sulfurylase from Penicillium chrysogenum Academic Article
- Allosteric inhibitors have distinct effects, but also common modes of action, in the HCV polymerase Academic Article
- Allosteric modulation of ampa-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, n-cam Academic Article
- Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine(7) receptors Academic Article
- Allosteric regulation of DNA cleavage and sequence-specificity through run-on oligomerization Academic Article
- Allosteric regulation of the 16-alpha-hydroxylation of progesterone as catalyzed by rabbit microsomal cytochrome-p-450-3b Academic Article
- Allosteric sodium in class A GPCR signaling Academic Article
- An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1 Academic Article
- Application of parallel multiparametric cell-based FLIPR detection assays for the identification of modulators of the muscarinic acetylcholine receptor 4 (M-4) Academic Article
- Bacterial chemoreceptor dynamics correlate with activity state and are coupled over long distances Academic Article
- Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): Efficacy in an animal model for schizophrenia Academic Article
- Bifacial peptide nucleic acid as an allosteric switch for aptamer and ribozyme function Academic Article
- Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor Academic Article
- Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans Academic Article
- CD44 receptor unfolding enhances binding by freeing basic amino acids to contact carbohydrate ligand Academic Article
- Calmodulin stabilizes an amphiphilic alpha-helix within rc3/neurogranin and gap-43/neuromodulin only when ca2+ is absent Academic Article
- Carbamyl phosphate binding to aspartate transcarbamylase. Partial saturation and its alteration by succinate Academic Article
- Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes Academic Article
- Cofactor-mediated conformational dynamics promote product release from Escherichia coli dihydrofolate reductase via an allosteric pathway Academic Article
- Conditional RNA interference mediated by allosteric ribozyme Academic Article
- Conformational changes in aspartate trancarbamylase. I. Studies of ligand binding and of subunit interactions by circular dichroism spectroscopy Academic Article
- Conformational changes in aspartate transcarbamylase. II. Circular dichroism evidence for the involvement of metal ions in allosteric interactions Academic Article
- Congenital disease snps target lineage specific structural elements in protein kinases Academic Article
- Constitutive forms of rabbit-liver microsomal cytochrome-P-450 - enzymatic diversity, polymorphism and allosteric regulation Academic Article
- Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel Academic Article
- Coupling of receptor conformation and ligand orientation determine graded activity Academic Article
- Crystal structure of atp sulfurylase from penicillium chrysogenum: Insights into the allosteric regulation of sulfate assimilation Academic Article
- Crystal structure of hsiuv complexed with a vinyl sulfone inhibitor: Corroboration of a proposed mechanism of allosteric activation of hsiv by hsiu Academic Article
- Crystal structure of the lactose operon repressor and its complexes with DNA and inducer Academic Article
- Crystallographic fragment-based drug discovery: use of a brominated fragment library targeting HIV protease Academic Article
- Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain Academic Article
- Designing allosteric control into enzymes by chemical rescue of structure Academic Article
- Development of a highly potent, novel M(5) positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)pipe ridine-4-carboxamide (ML380) Academic Article
- Discovery and SAR of muscarinic receptor subtype 1 (M-1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-Dibenzyl-2H-pyrazolo 4,3-c quinolin-3(5H)-ones as positive allosteric modulators Academic Article
- Discovery and characterization of novel allosteric FAK inhibitors Academic Article
- Discovery of 5-aryl-1,3-dihydro-2H-imidazo 4,5-b pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis Academic Article
- Discovery of a distinct chemical and mechanistic class of allosteric HIV-1 integrase inhibitors with antiretroviral activity Academic Article
- Discovery of a novel class of negative allosteric modulator of the dopamine D-2 receptor through fragmentation of a bitopic ligand Academic Article
- Discovery of allosteric inhibitors of kinesin spindle protein (KSP) for the treatment of taxane-refractory cancer: MK-0731 and analogs Academic Article
- Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia Academic Article
- Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators Academic Article
- Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375) Academic Article
- Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space Academic Article
- Dual allosteric inhibitors jointly modulate protein structure and dynamics in the hepatitis C virus polymerase Academic Article
- GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models Academic Article
- Gating movement of acetylcholine receptor caught by plunge-freezing Academic Article
- Girk channel modulation by assembly with allosterically regulated RGS proteins Academic Article
- Hidden allostery in human glutathione transferase p1-1 unveiled by unnatural amino acid substitutions and inhibition studies Academic Article
- High-throughput FRET assay yields allosteric SERCA activators Academic Article
- High-throughput assay and engineering of self-cleaving ribozymes by sequencing Academic Article
- Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators Academic Article
- Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors Academic Article
- Importance of a conserved residue, aspartate-162, for the function of escherichia-coli aspartate transcarbamoylase Academic Article
- In vitro selection of nucleic acids and proteins: what are we learning? Academic Article
- Induction of positive cooperativity by amino acid replacements within the C-terminal domain of penicillium chrysogenum ATP sulfurylase Academic Article
- Influence of cofactor binding and active site occupancy on the conformation of the macromolecular substrate exosite of factor viia Academic Article
- Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models Academic Article
- Interaction between beta-adrenergic receptors and guanine-nucleotide sites in turkey erythrocyte-membranes Academic Article
- Intraspecies individuality for the metabolism of steroids Academic Article
- Ligand-binding dynamics rewire cellular signaling via estrogen receptor-alpha Academic Article
- Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers Academic Article
- Mechanisms for zinc and proton inhibition of the GluN1/GluN2A NMDA receptor Academic Article
- Metabolic flux responses to pyruvate kinase knockout in escherichia coli Academic Article
- Mode of action for linear peptide inhibitors of hiv-1 gp120 interactions Academic Article
- Modulation of allostery by protein intrinsic disorder Academic Article
- Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis Academic Article
- Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone Academic Article
- Molecular architecture of human polycomb repressive complex 2 Academic Article
- Molecular control of delta-opioid receptor signalling Academic Article
- Molecular mechanism of the sweet taste enhancers Academic Article
- Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation Academic Article
- Nucleotide regulation of soluble guanylate cyclase substrate specificity Academic Article
- P53 latency - out of the blind alley Academic Article
- Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators Academic Article
- Positive allosteric modulators to peptide GPCRs: A promising class of drugs Academic Article
- Potent mechanism-based inactivation of cytochrome p450 2b4 by 9-ethynylphenanthrene: Implications for allosteric modulation of cytochrome p450 catalysis Academic Article
- Probing protein disorder and complexity at single-molecule resolution Academic Article
- Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia Academic Article
- Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion Academic Article
- Protein-protein interactions involved in the recognition of p27 by e3 ubiquitin ligase Academic Article
- Proton uptake accompanies formation of the ternary complex of citrate synthase, oxaloacetate, and the transition-state analog inhibitor, carboxymethyl-CoA. Evidence that a neutral enol is the activated form of acetyl-CoA in the citrate synthase reaction Academic Article
- Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif Academic Article
- Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation Academic Article
- Retinoid x receptor is a nonsilent major contributor to vitamin d receptor-mediated transcriptional activation Academic Article
- Reversible activation of non-steroid binding oestrogen receptor Academic Article
- Role of residue phe(225) in the cofactor-mediated, allosteric regulation of the serine protease coagulation factor viia Academic Article
- Sodium ion binding pocket mutations and adenosine A2A receptor function Academic Article
- Soluble guanylate cyclase is activated differently by excess no and by yc-1: Resonance raman spectroscopic evidence Academic Article
- Stable expression of recombinant ampa receptor subunits: Binding affinities and effects of allosteric modulators Academic Article
- Structural basis for allosteric regulation of GPCRs by sodium ions Academic Article
- Structural basis for the root effect in haemoglobin Academic Article
- Structural basis of autoregulation of phenylalanine hydroxylase Academic Article
- Structural interconversions modulate activity of escherichia coli ribonucleotide reductase Academic Article
- Structural mechanisms of allostery and autoinhibition in JNK family kinases Academic Article
- Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator Academic Article
- Structure of the intact ppar-gamma-rxr-alpha nuclear receptor complex on DNA Academic Article
- Structure, distribution, and functional expression of the phosphofructokinase-c isozyme Academic Article
- Structure-function of the G protein-coupled receptor superfamily Academic Article
- Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors Academic Article
- Target of γ-secretase modulators, presenilin marks the spot Academic Article
- Temperature effects on the allosteric transition of atp sulfurylase from penicillium chrysogenum Academic Article
- The 5' leader of the mRNA encoding the Marek's disease virus serotype 1 pp14 protein contains an intronic internal ribosome entry site with allosteric properties Academic Article
- The E-2.65 A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors Academic Article
- The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity Academic Article
- The expanding view of RNA and DNA function Academic Article
- The interaction of activated factor vii with tissue factor: Insight into the mechanism of cofactor-mediated activation of activated factor vii Academic Article
- The role of a sodium ion binding site in the allosteric modulation of the A2A adenosine G protein-coupled receptor Academic Article
- The role of cysteine 206 in allosteric inhibition of Escherichia coli citrate synthase. Studies by chemical modification, site-directed mutagenesis, and 19-F NMR Academic Article
- The structural basis of function of the TF. VIIa complex in the cellular initiation of coagulation Academic Article
- The structure of apo human glutamate dehydrogenase details subunit communication and allostery Academic Article
- Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase Academic Article
- Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site Academic Article
- Turning a protein kinase on or off from a single allosteric site via disulfide trapping Academic Article
- Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide Academic Article
- Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide Academic Article