subject area of

• A GTP affinity probe for proteomics highlights flexibility in purine nucleotide selectivity  Academic Article
• A cell free system to study reassembly of the nuclear-envelope at the end of mitosis  Academic Article
• A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (ppar alpha) versus liver x receptor  Academic Article
• A conserved MutS homolog connector domain interface interacts with MutL homologs  Academic Article
• A cyclic nucleotide-dependent chloride conductance in olfactory receptor neurons  Academic Article
• A detergent-activated tyrosinase from xenopus-laevis .1. Purification and partial characterization  Academic Article
• A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation  Academic Article
• A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd  Academic Article
• A major conformational change in p97 aaa atpase upon atp binding  Academic Article
• A mechanism for microtubule depolymerization by kini kinesins  Academic Article
• A methylation-mediator complex in hormone signaling  Academic Article
• A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase  Academic Article
• A novel prefusion complex formed during protein-transport between golgi cisternae in a cell-free system  Academic Article
• A ph sensitive colorometric assay for the high-throughput screening of enzyme inhibitors and substrates: A case study using kinases  Academic Article
• A role of the fast ATP-gated P2X(1) cation channel in thrombosis of small arteries in vivo  Academic Article
• A small molecule inhibitor selective for a variant atp-binding site of the chaperonin groel  Academic Article
• A source of response regulator autophosphatase activity: The critical role of a residue adjacent to the spo0f autophosphorylation active site  Academic Article
• A structural basis for the regulatory inactivation of DnaA  Academic Article
• ATP alone triggers the outward facing conformation of the maltose ATP-binding cassette transporter  Academic Article
• ATP and the core "alpha-crystallin" domain of the small heat-shock protein alpha B-crystallin  Academic Article
• ATP binding turns plant cryptochrome into an efficient natural photoswitch  Academic Article
• ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor  Academic Article
• ATP mediated receptor interconversion as a model of estrogen action: isolation of the factor which converts the non-estrogen binding form of the receptor to the lower affinity binding form  Academic Article
• ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A  Academic Article
• ATP-dependent chromatin remodeling enzymes: two heads are not better, just different  Academic Article
• ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase  Academic Article
• ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling  Academic Article
• Action of norepinephrine in rat hippocampus .1. Iontophoretic studies  Academic Article
• Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1  Academic Article
• Activation of rat mast cells by low-molecular weight stimuli  Academic Article
• Activity of yeast extracts in cell-free stimulation of DNA-replication  Academic Article
• Activity-based protein profiling: From enzyme chemistry to proteomic chemistry  Academic Article
• Adenosine 5 '-phosphosulfate kinase from Penicillium chrysogenum - site-directed mutagenesis at putative phosphoryl-accepting and ATP P-loop residues  Academic Article
• Affinity labeling of creatine kinase by N-(2,3-epoxypropyl)-N-amidinoglycine  Academic Article
• Affinity purification-mass spectrometry and network analysis to understand protein-protein interactions  Academic Article
• Agonist-bound structure of the human P2Y(12) receptor  Academic Article
• Allosteric communication in the dynein motor domain  Academic Article
• Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury  Academic Article
• Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head  Academic Article
• An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1  Academic Article
• An aminoacyl-tRNA synthetase that specifically activates pyrrolysine  Academic Article
• An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance  Academic Article
• An unusual tryptophanyl tRNA synthetase interacts with nitric oxide synthase in Deinococcus radiodurans  Academic Article
• Annonacin, a natural mitochondrial complex i inhibitor, causes tau pathology in cultured neurons  Academic Article
• Anti-diabetic drug binding site in a mammalian K-ATP channel revealed by Cryo-EM  Academic Article
• Aptly named aptamers display their aptitude  Academic Article
• Archaeal flagellar atpase motor shows atp-dependent hexameric assembly and activity stimulation by specific lipid binding  Academic Article
• Arginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo  Academic Article
• Ascorbic acid enhances the effects of 6-hydroxydopamine and H2O2 on iron-dependent DNA strand breaks and related processes in the neuroblastoma cell line SK-N-SH  Academic Article
• Assaying prions in cell culture: the standard scrapie cell assay (SSCA) and the scrapie cell assay in end point format (SCEPA)  Academic Article
• Atp induces conformational changes in the carboxyl-terminal region of clc-5  Academic Article
• Atp is required for receptor-mediated endocytosis in intact-cells  Academic Article
• Atp- and cytosol-dependent release of adaptor proteins from clathrin-coated vesicles: A dual role for hsc70  Academic Article
• Atp-stimulated, DNA-mediated redox signaling by xpd, a DNA repair and transcription helicase  Academic Article
• Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis  Academic Article
• Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase  Academic Article
• C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism  Academic Article
• Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles  Academic Article
• Cellular injury by oxidants  Academic Article
• Changes in the profile structure of the sarcoplasmic-reticulum membrane induced by phosphorylation of the Ca2+ ATPase enzyme in the presence of terbium: a time-resolved x-ray-diffraction study  Academic Article
• Character of stored molecules in chromaffin granules of adrenal-medulla - nuclear magnetic-resonance study  Academic Article
• Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.  Academic Article
• Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme a reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition  Academic Article
• Characterization of protein-transport between successive compartments of the golgi-apparatus - asymmetric properties of donor and acceptor activities in a cell-free system  Academic Article
• Characterization of the initial alpha-thrombin interaction with glycoprotein Ib alpha in relation to platelet activation  Academic Article
• Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1  Academic Article
• Chemical expansion of cofactor activity  Academic Article
• Chemoenzymatic synthesis of GDP-L-fucose and the Lewis X glycan derivatives  Academic Article
• Co-translational targeting and translocation of the amino terminus of opsin across the endoplasmic membrane requires gtp but not atp  Academic Article
• Complete subunit architecture of the proteasome regulatory particle  Academic Article
• Concise synthesis of pochonin A, an HSP90 inhibitor  Academic Article
• Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle  Academic Article
• Conformational switching of the 26S proteasome enables substrate degradation  Academic Article
• Construction of intra-domain chimeras of aminoacyl-tRNA synthetases  Academic Article
• Coupling distant sites in DNA during DNA mismatch repair  Academic Article
• Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating  Academic Article
• Crystal structure of ATP sulfurylase from the bacterial symbiont of the hydrothermal vent tubeworm Riftia pachyptila  Academic Article
• Crystal structure of group II chaperonin in the open state  Academic Article
• Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis  Academic Article
• Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP  Academic Article
• Crystal-structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and ctp or atp at 2.8-a resolution and neutral ph  Academic Article
• Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors  Academic Article
• Cytoplasmic extracts from adipose tissue stromal cells alleviates secondary damage by modulating apoptosis and promotes functional recovery following spinal cord injury  Academic Article
• DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals  Academic Article
• DNA double-strand break repair from head to tail  Academic Article
• Depletion of calcium from the lumen of endoplasmic-reticulum reversibly inhibits passive diffusion and signal-mediated transport into the nucleus  Academic Article
• Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors  Academic Article
• Direct and specific photochemical cross-linking of adenosine 5'-triphosphate to an aminoacyl-tRNA synthetase  Academic Article
• Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP  Academic Article
• Discovery of a small molecule insulin mimetic with antidiabetic activity in mice  Academic Article
• Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors  Academic Article
• Dissection of the functional and structural domains of phosphorelay histidine kinase a of bacillus subtilis  Academic Article
• Dissociation of clathrin coats coupled to the hydrolysis of atp - role of an uncoating atpase  Academic Article
• Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors  Academic Article
• Domain interdependence in the biosynthetic assembly of CFTR  Academic Article
• Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase  Academic Article
• Effect of 2-3-diphosphoglycerate and ATP on ethyl isocyanide binding to human hemoglobin  Academic Article
• Effect of transfer ribonucleic acid on the rate law and mechanism of the adenosine triphosphate: pyrophosphate isotope exchange reaction of an aminoacyl transfer ribonucleic acid synthetase  Academic Article
• Elucidation of tRNA-dependent editing by a class II tRNA synthetase and significance for cell viability  Academic Article
• Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies  Academic Article
• Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore  Academic Article
• Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair  Academic Article
• Enzymatic incorporation of an antibody-activated blue fluorophore into DNA  Academic Article
• Enzymatic recycling of clathrin from coated vesicles  Academic Article
• Enzymatic regeneration of adenosine 5'-triphosphate: acetyl phosphate, phosphoenolpyruvate, methoxycarbonyl phosphate, dihydroxyacetone phosphate, 5-phospho-alpha-D-ribosyl pyrophosphate, uridine-5'-diphosphoglucose  Academic Article
• Enzymatic synthesis and 19F NMR studies of 2-fluoroadenine-substituted RNA  Academic Article
• Enzymatic synthesis and structural characterization of 13C, 15N-poly(ADP-ribose)  Academic Article
• Evidence for the regulation of exocytic transport by protein-phosphorylation  Academic Article
• Evidence that the 3' end of a tRNA binds to a site in the adenylate synthesis domain of an aminoacyl-tRNA synthetase  Academic Article
• External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification  Academic Article
• Flavonoids protect retinal ganglion cells from ischemia in vitro  Academic Article
• Flexibility in the ABC transporter MsbA: Alternating access with a twist  Academic Article
• Folding trajectories of human dihydrofolate reductase inside the GroEL GroES chaperonin cavity and free in solution  Academic Article
• Function independence of microhelix aminoacylation from anticodon binding in a class I tRNA synthetase  Academic Article
• Functional interrogation of kinases and other nucleotide-binding proteins  Academic Article
• GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import  Academic Article
• Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration  Academic Article
• Global human-kinase screening identifies therapeutic host targets against influenza  Academic Article
• Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles  Academic Article
• Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition  Academic Article
• Heavy-metals and adenosine cyclic 3',5'-monophosphate metabolism - possible relevance to heavy-metal toxicity  Academic Article
• HepG2 cells infected with Klebsiella pneumoniae show DNA laddering at apoptotic and necrotic stages  Academic Article
• High-throughput screening for small molecule modulators of motor protein Kinesin  Academic Article
• Homology dependence of uvsx protein-catalyzed joint molecule formation  Academic Article
• Hsp90 inhibition with resorcyclic acid lactones (RALs)  Academic Article
• Hydrogen peroxide as a potent bacteriostatic antibiotic: implications for host defense  Academic Article
• Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase  Academic Article
• Identification of NSF as a beta-arrestin1-binding protein - implications for beta(2)-adrenergic receptor regulation  Academic Article
• Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion  Academic Article
• Immunosuppressive effects of glucosamine  Academic Article
• Importance of a conserved residue, aspartate-162, for the function of escherichia-coli aspartate transcarbamoylase  Academic Article
• In situ kinase profiling reveals functionally relevant properties of native kinases  Academic Article
• In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1  Academic Article
• Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation  Academic Article
• Inhibition of protein kinases by balanol: Specificity within the serine/threonine protein kinase subfamily  Academic Article
• Inhibition of protein-mediated homologous pairing by a DNA helicase  Academic Article
• Initiation of replication in chromosomal DNA induced by extracts from proliferating cells  Academic Article
• Insights into FlaI functions in archaeal motor assembly and motility from structures, conformations, and genetics  Academic Article
• Interaction of human hemoglobin with adenine nucleotides  Academic Article
• Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D1 cells  Academic Article
• Investigation of the transfer of amino acid from a transfer ribonucleic acid synthetase-aminoacyl adenylate complex to transfer ribonucleic acid  Academic Article
• Isoleucyl transfer ribonucleic acid synthetase. The role of magnesium in amino acid activation  Academic Article
• Kinase signaling initiates coat complex II (COPII) recruitment and export from the mammalian endoplasmic reticulum  Academic Article
• Kinesin follows the microtubules protofilament axis  Academic Article
• Kinetic and spectroscopic evidence for three actomyosin : Adp states in smooth muscle  Academic Article
• Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3 alpha 1  Academic Article
• Kinetic mechanism for p38 map kinase  Academic Article
• Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics  Academic Article
• Kinomics-structural biology and chemogenomics of kinase inhibitors and targets  Academic Article
• LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid-hormones  Academic Article
• Lateral mobility of human erythrocyte integral membrane proteins  Academic Article
• Lead-induced inhibition of brain adenyl-cyclase  Academic Article
• Linking chemical electron-proton transfer to proton pumping in cytochrome c oxidase: broken-symmetry DFT exploration of intermediates along the catalytic reaction pathway of the iron-copper dinuclear complex  Academic Article
• Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha  Academic Article
• Mapping the structure of specific protein-transfer RNA complexes by a tritium labeling method  Academic Article
• Maturation of human cyclin e requires the function of eukaryotic chaperonin cct  Academic Article
• Mechanism of Action of an Imidopiperidine Inhibitor of Human Polynucleotide Kinase/Phosphatase  Academic Article
• Mechanism of aminoglycoside 3'-phosphotransferase type iiia: His188 is not a phosphate-accepting residue  Academic Article
• Mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia: Role of the nucleotide positioning loop  Academic Article
• Mechanism of toxicity in rotenone models of parkinson's disease  Academic Article
• Mechanism of toxicity of pesticides acting at complex i: Relevance to environmental etiologies of parkinson's disease  Academic Article
• Mechanistic characterization for c-jun-n-terminal kinase 1 alpha 1  Academic Article
• Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation  Academic Article
• Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs  Academic Article
• Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo  Academic Article
• Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons  Academic Article
• Mitochondrial dysfunction in ataxia-telangiectasia  Academic Article
• Mitochondrial fission is an upstream and required event for Bax foci formation in response to nitric oxide in cortical neurons  Academic Article
• Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization  Academic Article
• Modeling general proteostasis: Proteome balance in health and disease  Academic Article
• Modular arrangement of functional domains along the sequence of an aminoacyl tRNA synthetase  Academic Article
• Modulating effect of cholera enterotoxin on immune-response  Academic Article
• Modulation of the kinetics and the steady-state level of intermediates of mitochondrial coupled reactions by inhibitors and uncouplers  Academic Article
• Molecular basis for p38 protein kinase inhibitor specificity  Academic Article
• Molecular design and biological-activity of potent and selective protein-kinase inhibitors related to balanol  Academic Article
• Molecular mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia - roles of conserved active site residues  Academic Article
• Monitoring native p38α:MK2/3 complexes via trans delivery of an ATP acyl phosphate probe  Academic Article
• Multiple cycles of global unfolding of groel-bound cyclophilin a evidenced by NMR  Academic Article
• Mutational activation of c-raf-1 and definition of the minimal transforming sequence  Academic Article
• Mutational isolation of a sieve for editing in a transfer RNA synthetase  Academic Article
• Myosin II contributes to cell-scale actin network treadmilling through network disassembly  Academic Article
• NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase  Academic Article
• NMR structures of α-proteobacterial ATPase-regulating ζ-subunits  Academic Article
• Negative regulation of the Apaf-1 apoptosome by Hsp70  Academic Article
• Negative stain single-particle EM of the maltose transporter in nanodiscs reveals asymmetric closure of MalK2 and catalytic roles of ATP, MalE, and maltose  Academic Article
• Neuroadaptive mechanisms of addiction: Studies on the extended amygdala  Academic Article
• Neuropeptide Y receptors and the inhibition of adenylate cyclase in the human frontal and temporal cortex  Academic Article
• Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons  Academic Article
• Nucleocytoplasmic shuttling factors including ran and crm1 mediate nuclear export of nfat in vitro  Academic Article
• Nucleotide binding by the histidine kinase CheA  Academic Article
• Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA  Academic Article
• Nucleotide regulation of soluble guanylate cyclase substrate specificity  Academic Article
• Nucleotide-free MalK drives the transition of the maltose transporter to the inward-facing conformation  Academic Article
• Oligomerization of immunoglobulin-g heavy and light-chains in vitro - a cell-free assay to study the assembly of the endoplasmic-reticulum  Academic Article
• On the mechanism of h+ translocation by mitochondrial h+-atpase - studies with chemical modifier of tyrosine residues  Academic Article
• On the rate law and mechanism of the adenosine triphosphate-pyrophosphate isotope exchange reaction of amino acyl transfer ribonucleic acid synthetases  Academic Article
• Orthovanadate induces loss of muscarinic cholinergic binding sites  Academic Article
• Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide  Academic Article
• Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding  Academic Article
• P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice  Academic Article
• P38 map kinase substrate specificity differs greatly for protein and peptide substrates  Academic Article
• PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity  Academic Article
• Parallel biomolecular computation on surfaces with advanced finite automata  Academic Article
• Pas-a domain of phosphorelay sensor kinase a: A catalytic atp-binding domain involved in the initiation of development in bacillus subtilis  Academic Article
• Pathway engineered enzymatic de novo purine nucleotide synthesis  Academic Article
• Pathways of nucleoprotein assembly on 5S-RNA genes in a Xenopus oocyte S-150 extract  Academic Article
• Phage-display evolution of tyrosine kinases with altered nucleotide specificity  Academic Article
• Phosphatidylglycerol directs binding and inhibitory action of EIIAGlc protein on the maltose transporter  Academic Article
• Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro  Academic Article
• Polynucleotide ligase from myeloid and lymphoid tissues  Academic Article
• Polypeptide sequences essential for RNA recognition by an enzyme  Academic Article
• Polyphosphoinositide synthesis in human neutrophils - effects of a low metabolic energy state  Academic Article
• Possible steps of complete disassembly of post-termination complex by yeast eef3 deduced from inhibition by translocation inhibitors  Academic Article
• Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy  Academic Article
• Predicting the conformational variability of Abl tyrosine kinase using molecular dynamics simulations and Markov state models  Academic Article
• Preparation of metal-chelate complexes and the design of steady-state kinetic experiments involving metal nucleotide complexes  Academic Article
• Preparation of semiintact cells for study of vesicular trafficking in-vitro  Academic Article
• Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry  Academic Article
• Probing adenylation: Using a fluorescently labelled atp probe to directly label and immunoprecipitate vops substrates  Academic Article
• Profiling protein kinases and other ATP binding proteins in Arabidopsis using Acyl-ATP probes  Academic Article
• Programmable and autonomous computing machine made of biomolecules  Academic Article
• Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes  Academic Article
• Protein conformation ensembles monitored by HDX reveal a structural rationale for abscisic acid signaling protein affinities and activities  Academic Article
• Proton nuclear magnetic resonance and electron paramagnetic resonance studies on skeletal muscle actin indicate that the metal and nucleotide binding sites are separate  Academic Article
• Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase  Academic Article
• RNA-Dependent cysteine biosynthesis in archaea  Academic Article
• RNA-dependent cysteine biosynthesis in archaea  Academic Article
• Rab-alpha GDI activity is regulated by a Hsp90 chaperone complex  Academic Article
• Rapid deacylation by isoleucyl transfer ribonucleic acid synthetase of isoleucine-specific transfer ribonucleic acid aminoacylated with valine  Academic Article
• Recent advances of MEK inhibitors and their clinical progress  Academic Article
• Recognition templates for predicting adenylate-binding sites in proteins  Academic Article
• Recruitment of epidermal growth-factor and transferrin receptors into coated pits in-vitro - differing biochemical requirements  Academic Article
• Regulation of Shaker K+ channel inactivation gating by the cAMP-dependent protein kinase  Academic Article
• Release of aminoacyl transfer ribonucleic acid from transfer ribonucleic acid synthetase studied by rapid molecular sieve chromatography  Academic Article
• Removal of impurities from transcription factor preparations that alter their DNA-binding properties  Academic Article
• Requirement for binding multiple ATPs to convert a GroEL ring to the folding-active state  Academic Article
• Reversible activation of non-steroid binding oestrogen receptor  Academic Article
• Role for adenosine-triphosphate in regulating the assembly and transport of vesicular stomatitis-virus g protein trimers  Academic Article
• Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome  Academic Article
• Role of vesicle-associated syntaxin 5 in the assembly of pre-Golgi intermediates  Academic Article
• SIR1, an upstream component in auxin signaling identified by chemical genetics  Academic Article
• Selective ATP-competitive inhibitors of TOR suppress rapamycin-insensitive function of TORC2 in Saccharomyces cerevisiae  Academic Article
• Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk  Academic Article
• Semi-intact cells permeable to macromolecules - use in reconstitution of protein-transport from the endoplasmic-reticulum to the golgi-complex  Academic Article
• Sequential action of MalE and maltose allows coupling ATP hydrolysis to translocation in the MalFGK(2) transporter  Academic Article
• Sequential intermediates in the pathway of intercompartmental transport in a cell-free system  Academic Article
• Sequential intermediates in the transport of protein between the endoplasmic-reticulum and the golgi  Academic Article
• Serum suppresses myeloid progenitor apoptosis by regulating iron homeostasis  Academic Article
• Sh3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation  Academic Article
• Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation  Academic Article
• Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts  Academic Article
• Small terminase couples viral DNA binding to genome-packaging ATPase activity  Academic Article
• Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein  Academic Article
• Sod2-deficiency anemia: Protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness  Academic Article
• Spectinomycin kinase from legionella pneumophila - characterization of substrate specificity and identification of catalytically important residues  Academic Article
• Stage-specific assays for coated pit formation and coated vesicle budding in vitro  Academic Article
• Structural analysis of the RSC chromatin-remodeling complex  Academic Article
• Structural and chemical requirements for histidine phosphorylation by the chemotaxis kinase CheA  Academic Article
• Structural basis for specific inhibition of tRNA synthetase by an ATP competitive inhibitor  Academic Article
• Structural consequences of effector binding to the t-state of aspartate carbamoyltransferase - crystal-structures of the unligated and atp-complexed and ctp-complexed enzymes at 2.6-a resolution  Academic Article
• Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B  Academic Article
• Structure and functional role of dynein's microtubule-binding domain  Academic Article
• Structure and mechanism of the ruvb holliday junction branch migration motor  Academic Article
• Structure and regulatory mechanism of Aquifex aeolicus NtrC4: variability and evolution in bacterial transcriptional regulation  Academic Article
• Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding  Academic Article
• Structure of the actin-myosin complex and its implications for muscle-contraction  Academic Article
• Structure of the pilus assembly protein TadZ from eubacterium rectale: Implications for polar localization  Academic Article
• Structures of tryptophanyl-tRNA synthetase II from Deinococcus radiodurans bound to ATP and tryptophan. Insight into subunit cooperativity and domain motions linked to catalysis  Academic Article
• Studies on norepinephrine-containing afferents to purkinje cells of rat cerebellum. 3. Evidence for mediation of norepinephrine effects by cyclic 3',5'-adenosine monophosphate  Academic Article
• Studies on the mechanism of oxidative-phosphorylation - effects of specific f-0 modifiers on ligand-induced conformation changes of f1  Academic Article
• Substituting c-jun n-terminal kinase-3 (jnk3) atp-binding site amino acid residues with their p38 counterparts affects binding of jnk- and p38-selective inhibitors  Academic Article
• Substrate binding-affinity changes in mitochondrial energy-linked reactions  Academic Article
• Substrate recognition and selection by the initiation module PheATE of gramicidin S synthetase  Academic Article
• Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90  Academic Article
• Suppressors of superoxide production from mitochondrial complex III  Academic Article
• Synergistic kinetic interactions between components of the phosphorelay controlling sporulation in bacillus subtilis  Academic Article
• Synthesis and activity of new aryl- and heteroaryl- substituted pyrazole inhibitors of the transforming growth factor-βtype I receptor kinase domain  Academic Article
• Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors  Academic Article
• Synthesis of a resorcylic acid lactone (RAL) library using fluorous-mixture synthesis and profile of its selectivity against a panel of kinases  Academic Article
• Synthetic peptides of the effector-binding domain of rab enhance secretion from digitonin-permeabilized chromaffin cells  Academic Article
• TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP  Academic Article
• The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits  Academic Article
• The action of cardiolipin on the bacterial translocon  Academic Article
• The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1 beta under acidic extracellular pH in LPS-primed microglial cells  Academic Article
• The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes  Academic Article
• The crystal structures of chloramphenicol phosphotransferase reveal a novel inactivation mechanism  Academic Article
• The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism  Academic Article
• The design and synthesis of novel alpha-ketoamide-based p38 map kinase inhibitors  Academic Article
• The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines  Academic Article
• The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme  Academic Article
• The influence of nitric oxide on soluble guanylate cyclase regulation by nucleotides: Role of the pseudosymmetric site  Academic Article
• The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas  Academic Article
• The maltose ABC transporter: Action of membrane lipids on the transporter stability, coupling and ATPase activity  Academic Article
• The mechanism of receptor-mediated endocytosis - more questions than answers  Academic Article
• The molecular principles governing the activity and functional diversity of AAA plus proteins  Academic Article
• The motor protein myosin-i produces its working stroke in two steps  Academic Article
• The neurohormone orexin stimulates hypoxia-inducible factor-1 activity  Academic Article
• The properties of Msh2-Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair  Academic Article
• The protective effects of nucleotides on the histamine hypersensitivity of Bordetella pertussis-treated mice  Academic Article
• The rad50 signature motif: Essential to atp binding and biological function  Academic Article
• The role of protein-protein interactions in the assembly of the presynaptic filament for t4 homologous recombination  Academic Article
• The role of the kinesin-13 neck in microtubule depolymerization  Academic Article
• The role of the proteasomal ATPases and activator monoubiquitylation in regulating Gal4 binding to promoters  Academic Article
• The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type iiptrases  Academic Article
• The structure of jnk3 in complex with small molecule inhibitors: Structural basis for potency and selectivity  Academic Article
• The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux  Academic Article
• The thermotoga maritima trk potassium transporter-from frameshift to function  Academic Article
• The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA  Academic Article
• The way things move: Looking under the hood of molecular motor proteins  Academic Article
• The ydaO motif is an ATP-sensing riboswitch in Bacillus subtilis  Academic Article
• Tissue factor prothrombotic activity is regulated by integrin-arf6 trafficking  Academic Article
• Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, atp, and gtp  Academic Article
• TorsinA and torsion dystonia: unraveling the architecture of the nuclear envelope  Academic Article
• Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis  Academic Article
• Transfer ribonucleic acid synthetase catalyzed deacylation of aminoacyl transfer ribonucleic acid in the absence of adenosine monophosphate and pyrophosphate  Academic Article
• Tumor regression by targeted gene delivery to the neovasculature  Academic Article
• Two classes give lessons about CCA  Academic Article
• Two classes of binding sites for uncoating protein in clathrin triskelions  Academic Article
• Two classes of tRNA synthetases suggested by sterically compatible dockings on tRNA acceptor stem  Academic Article
• Two distinct mechanisms for the initiation of mast cell degranulation  Academic Article
• Unique interactions of asialo von Willebrand factor with platelets in platelet-type von Willebrand disease  Academic Article
• Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib  Academic Article
• Use of a semisynthetic epitope to probe histidine kinase activity and regulation  Academic Article
• Variations in the in vivo P-31 MR spectra of the developing human brain during postnatal life. Work in progress  Academic Article
• Xol-1, primary determinant of sexual fate in c. Elegans, is a ghmp kinase family member and a structural prototype for a class of developmental regulators  Academic Article
• Xpb and xpd helicases in tfiih orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via cak kinase  Academic Article
• YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress  Academic Article