subject area of
- A GTP affinity probe for proteomics highlights flexibility in purine nucleotide selectivity Academic Article
- A cell free system to study reassembly of the nuclear-envelope at the end of mitosis Academic Article
- A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (ppar alpha) versus liver x receptor Academic Article
- A conserved MutS homolog connector domain interface interacts with MutL homologs Academic Article
- A cyclic nucleotide-dependent chloride conductance in olfactory receptor neurons Academic Article
- A detergent-activated tyrosinase from xenopus-laevis .1. Purification and partial characterization Academic Article
- A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation Academic Article
- A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd Academic Article
- A major conformational change in p97 aaa atpase upon atp binding Academic Article
- A mechanism for microtubule depolymerization by kini kinesins Academic Article
- A methylation-mediator complex in hormone signaling Academic Article
- A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase Academic Article
- A novel prefusion complex formed during protein-transport between golgi cisternae in a cell-free system Academic Article
- A ph sensitive colorometric assay for the high-throughput screening of enzyme inhibitors and substrates: A case study using kinases Academic Article
- A role of the fast ATP-gated P2X(1) cation channel in thrombosis of small arteries in vivo Academic Article
- A small molecule inhibitor selective for a variant atp-binding site of the chaperonin groel Academic Article
- A source of response regulator autophosphatase activity: The critical role of a residue adjacent to the spo0f autophosphorylation active site Academic Article
- A structural basis for the regulatory inactivation of DnaA Academic Article
- ATP alone triggers the outward facing conformation of the maltose ATP-binding cassette transporter Academic Article
- ATP and the core "alpha-crystallin" domain of the small heat-shock protein alpha B-crystallin Academic Article
- ATP binding turns plant cryptochrome into an efficient natural photoswitch Academic Article
- ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor Academic Article
- ATP mediated receptor interconversion as a model of estrogen action: isolation of the factor which converts the non-estrogen binding form of the receptor to the lower affinity binding form Academic Article
- ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A Academic Article
- ATP-dependent chromatin remodeling enzymes: two heads are not better, just different Academic Article
- ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase Academic Article
- ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling Academic Article
- Action of norepinephrine in rat hippocampus .1. Iontophoretic studies Academic Article
- Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1 Academic Article
- Activation of rat mast cells by low-molecular weight stimuli Academic Article
- Activity of yeast extracts in cell-free stimulation of DNA-replication Academic Article
- Activity-based protein profiling: From enzyme chemistry to proteomic chemistry Academic Article
- Adenosine 5 '-phosphosulfate kinase from Penicillium chrysogenum - site-directed mutagenesis at putative phosphoryl-accepting and ATP P-loop residues Academic Article
- Affinity labeling of creatine kinase by N-(2,3-epoxypropyl)-N-amidinoglycine Academic Article
- Affinity purification-mass spectrometry and network analysis to understand protein-protein interactions Academic Article
- Agonist-bound structure of the human P2Y(12) receptor Academic Article
- Allosteric communication in the dynein motor domain Academic Article
- Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury Academic Article
- Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head Academic Article
- An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 Academic Article
- An aminoacyl-tRNA synthetase that specifically activates pyrrolysine Academic Article
- An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance Academic Article
- An unusual tryptophanyl tRNA synthetase interacts with nitric oxide synthase in Deinococcus radiodurans Academic Article
- Annonacin, a natural mitochondrial complex i inhibitor, causes tau pathology in cultured neurons Academic Article
- Anti-diabetic drug binding site in a mammalian K-ATP channel revealed by Cryo-EM Academic Article
- Aptly named aptamers display their aptitude Academic Article
- Archaeal flagellar atpase motor shows atp-dependent hexameric assembly and activity stimulation by specific lipid binding Academic Article
- Arginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo Academic Article
- Ascorbic acid enhances the effects of 6-hydroxydopamine and H2O2 on iron-dependent DNA strand breaks and related processes in the neuroblastoma cell line SK-N-SH Academic Article
- Assaying prions in cell culture: the standard scrapie cell assay (SSCA) and the scrapie cell assay in end point format (SCEPA) Academic Article
- Atp induces conformational changes in the carboxyl-terminal region of clc-5 Academic Article
- Atp is required for receptor-mediated endocytosis in intact-cells Academic Article
- Atp- and cytosol-dependent release of adaptor proteins from clathrin-coated vesicles: A dual role for hsc70 Academic Article
- Atp-stimulated, DNA-mediated redox signaling by xpd, a DNA repair and transcription helicase Academic Article
- Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis Academic Article
- Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase Academic Article
- C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism Academic Article
- Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles Academic Article
- Cellular injury by oxidants Academic Article
- Changes in the profile structure of the sarcoplasmic-reticulum membrane induced by phosphorylation of the Ca2+ ATPase enzyme in the presence of terbium: a time-resolved x-ray-diffraction study Academic Article
- Character of stored molecules in chromaffin granules of adrenal-medulla - nuclear magnetic-resonance study Academic Article
- Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. Academic Article
- Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme a reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition Academic Article
- Characterization of protein-transport between successive compartments of the golgi-apparatus - asymmetric properties of donor and acceptor activities in a cell-free system Academic Article
- Characterization of the initial alpha-thrombin interaction with glycoprotein Ib alpha in relation to platelet activation Academic Article
- Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1 Academic Article
- Chemical expansion of cofactor activity Academic Article
- Chemoenzymatic synthesis of GDP-L-fucose and the Lewis X glycan derivatives Academic Article
- Co-translational targeting and translocation of the amino terminus of opsin across the endoplasmic membrane requires gtp but not atp Academic Article
- Complete subunit architecture of the proteasome regulatory particle Academic Article
- Concise synthesis of pochonin A, an HSP90 inhibitor Academic Article
- Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle Academic Article
- Conformational switching of the 26S proteasome enables substrate degradation Academic Article
- Construction of intra-domain chimeras of aminoacyl-tRNA synthetases Academic Article
- Coupling distant sites in DNA during DNA mismatch repair Academic Article
- Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating Academic Article
- Crystal structure of ATP sulfurylase from the bacterial symbiont of the hydrothermal vent tubeworm Riftia pachyptila Academic Article
- Crystal structure of group II chaperonin in the open state Academic Article
- Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis Academic Article
- Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP Academic Article
- Crystal-structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and ctp or atp at 2.8-a resolution and neutral ph Academic Article
- Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors Academic Article
- Cytoplasmic extracts from adipose tissue stromal cells alleviates secondary damage by modulating apoptosis and promotes functional recovery following spinal cord injury Academic Article
- DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals Academic Article
- DNA double-strand break repair from head to tail Academic Article
- Depletion of calcium from the lumen of endoplasmic-reticulum reversibly inhibits passive diffusion and signal-mediated transport into the nucleus Academic Article
- Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors Academic Article
- Direct and specific photochemical cross-linking of adenosine 5'-triphosphate to an aminoacyl-tRNA synthetase Academic Article
- Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP Academic Article
- Discovery of a small molecule insulin mimetic with antidiabetic activity in mice Academic Article
- Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors Academic Article
- Dissection of the functional and structural domains of phosphorelay histidine kinase a of bacillus subtilis Academic Article
- Dissociation of clathrin coats coupled to the hydrolysis of atp - role of an uncoating atpase Academic Article
- Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors Academic Article
- Domain interdependence in the biosynthetic assembly of CFTR Academic Article
- Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase Academic Article
- Effect of 2-3-diphosphoglycerate and ATP on ethyl isocyanide binding to human hemoglobin Academic Article
- Effect of transfer ribonucleic acid on the rate law and mechanism of the adenosine triphosphate: pyrophosphate isotope exchange reaction of an aminoacyl transfer ribonucleic acid synthetase Academic Article
- Elucidation of tRNA-dependent editing by a class II tRNA synthetase and significance for cell viability Academic Article
- Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies Academic Article
- Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore Academic Article
- Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair Academic Article
- Enzymatic incorporation of an antibody-activated blue fluorophore into DNA Academic Article
- Enzymatic recycling of clathrin from coated vesicles Academic Article
- Enzymatic regeneration of adenosine 5'-triphosphate: acetyl phosphate, phosphoenolpyruvate, methoxycarbonyl phosphate, dihydroxyacetone phosphate, 5-phospho-alpha-D-ribosyl pyrophosphate, uridine-5'-diphosphoglucose Academic Article
- Enzymatic synthesis and 19F NMR studies of 2-fluoroadenine-substituted RNA Academic Article
- Enzymatic synthesis and structural characterization of 13C, 15N-poly(ADP-ribose) Academic Article
- Evidence for the regulation of exocytic transport by protein-phosphorylation Academic Article
- Evidence that the 3' end of a tRNA binds to a site in the adenylate synthesis domain of an aminoacyl-tRNA synthetase Academic Article
- External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification Academic Article
- Flavonoids protect retinal ganglion cells from ischemia in vitro Academic Article
- Flexibility in the ABC transporter MsbA: Alternating access with a twist Academic Article
- Folding trajectories of human dihydrofolate reductase inside the GroEL GroES chaperonin cavity and free in solution Academic Article
- Function independence of microhelix aminoacylation from anticodon binding in a class I tRNA synthetase Academic Article
- Functional interrogation of kinases and other nucleotide-binding proteins Academic Article
- GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import Academic Article
- Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration Academic Article
- Global human-kinase screening identifies therapeutic host targets against influenza Academic Article
- Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles Academic Article
- Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition Academic Article
- Heavy-metals and adenosine cyclic 3',5'-monophosphate metabolism - possible relevance to heavy-metal toxicity Academic Article
- HepG2 cells infected with Klebsiella pneumoniae show DNA laddering at apoptotic and necrotic stages Academic Article
- High-throughput screening for small molecule modulators of motor protein Kinesin Academic Article
- Homology dependence of uvsx protein-catalyzed joint molecule formation Academic Article
- Hsp90 inhibition with resorcyclic acid lactones (RALs) Academic Article
- Hydrogen peroxide as a potent bacteriostatic antibiotic: implications for host defense Academic Article
- Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase Academic Article
- Identification of NSF as a beta-arrestin1-binding protein - implications for beta(2)-adrenergic receptor regulation Academic Article
- Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion Academic Article
- Immunosuppressive effects of glucosamine Academic Article
- Importance of a conserved residue, aspartate-162, for the function of escherichia-coli aspartate transcarbamoylase Academic Article
- In situ kinase profiling reveals functionally relevant properties of native kinases Academic Article
- In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1 Academic Article
- Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation Academic Article
- Inhibition of protein kinases by balanol: Specificity within the serine/threonine protein kinase subfamily Academic Article
- Inhibition of protein-mediated homologous pairing by a DNA helicase Academic Article
- Initiation of replication in chromosomal DNA induced by extracts from proliferating cells Academic Article
- Insights into FlaI functions in archaeal motor assembly and motility from structures, conformations, and genetics Academic Article
- Interaction of human hemoglobin with adenine nucleotides Academic Article
- Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D1 cells Academic Article
- Investigation of the transfer of amino acid from a transfer ribonucleic acid synthetase-aminoacyl adenylate complex to transfer ribonucleic acid Academic Article
- Isoleucyl transfer ribonucleic acid synthetase. The role of magnesium in amino acid activation Academic Article
- Kinase signaling initiates coat complex II (COPII) recruitment and export from the mammalian endoplasmic reticulum Academic Article
- Kinesin follows the microtubules protofilament axis Academic Article
- Kinetic and spectroscopic evidence for three actomyosin : Adp states in smooth muscle Academic Article
- Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3 alpha 1 Academic Article
- Kinetic mechanism for p38 map kinase Academic Article
- Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics Academic Article
- Kinomics-structural biology and chemogenomics of kinase inhibitors and targets Academic Article
- LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid-hormones Academic Article
- Lateral mobility of human erythrocyte integral membrane proteins Academic Article
- Lead-induced inhibition of brain adenyl-cyclase Academic Article
- Linking chemical electron-proton transfer to proton pumping in cytochrome c oxidase: broken-symmetry DFT exploration of intermediates along the catalytic reaction pathway of the iron-copper dinuclear complex Academic Article
- Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha Academic Article
- Mapping the structure of specific protein-transfer RNA complexes by a tritium labeling method Academic Article
- Maturation of human cyclin e requires the function of eukaryotic chaperonin cct Academic Article
- Mechanism of Action of an Imidopiperidine Inhibitor of Human Polynucleotide Kinase/Phosphatase Academic Article
- Mechanism of aminoglycoside 3'-phosphotransferase type iiia: His188 is not a phosphate-accepting residue Academic Article
- Mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia: Role of the nucleotide positioning loop Academic Article
- Mechanism of toxicity in rotenone models of parkinson's disease Academic Article
- Mechanism of toxicity of pesticides acting at complex i: Relevance to environmental etiologies of parkinson's disease Academic Article
- Mechanistic characterization for c-jun-n-terminal kinase 1 alpha 1 Academic Article
- Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation Academic Article
- Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs Academic Article
- Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo Academic Article
- Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons Academic Article
- Mitochondrial dysfunction in ataxia-telangiectasia Academic Article
- Mitochondrial fission is an upstream and required event for Bax foci formation in response to nitric oxide in cortical neurons Academic Article
- Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization Academic Article
- Modeling general proteostasis: Proteome balance in health and disease Academic Article
- Modular arrangement of functional domains along the sequence of an aminoacyl tRNA synthetase Academic Article
- Modulating effect of cholera enterotoxin on immune-response Academic Article
- Modulation of the kinetics and the steady-state level of intermediates of mitochondrial coupled reactions by inhibitors and uncouplers Academic Article
- Molecular basis for p38 protein kinase inhibitor specificity Academic Article
- Molecular design and biological-activity of potent and selective protein-kinase inhibitors related to balanol Academic Article
- Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd Academic Article
- Molecular mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia - roles of conserved active site residues Academic Article
- Monitoring native p38α:MK2/3 complexes via trans delivery of an ATP acyl phosphate probe Academic Article
- Multiple cycles of global unfolding of groel-bound cyclophilin a evidenced by NMR Academic Article
- Mutational activation of c-raf-1 and definition of the minimal transforming sequence Academic Article
- Mutational isolation of a sieve for editing in a transfer RNA synthetase Academic Article
- Myosin II contributes to cell-scale actin network treadmilling through network disassembly Academic Article
- NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase Academic Article
- NMR structures of α-proteobacterial ATPase-regulating ζ-subunits Academic Article
- Negative regulation of the Apaf-1 apoptosome by Hsp70 Academic Article
- Negative stain single-particle EM of the maltose transporter in nanodiscs reveals asymmetric closure of MalK2 and catalytic roles of ATP, MalE, and maltose Academic Article
- Neuroadaptive mechanisms of addiction: Studies on the extended amygdala Academic Article
- Neuropeptide Y receptors and the inhibition of adenylate cyclase in the human frontal and temporal cortex Academic Article
- Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons Academic Article
- Nucleocytoplasmic shuttling factors including ran and crm1 mediate nuclear export of nfat in vitro Academic Article
- Nucleotide binding by the histidine kinase CheA Academic Article
- Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA Academic Article
- Nucleotide regulation of soluble guanylate cyclase substrate specificity Academic Article
- Nucleotide-free MalK drives the transition of the maltose transporter to the inward-facing conformation Academic Article
- Oligomerization of immunoglobulin-g heavy and light-chains in vitro - a cell-free assay to study the assembly of the endoplasmic-reticulum Academic Article
- On the mechanism of h+ translocation by mitochondrial h+-atpase - studies with chemical modifier of tyrosine residues Academic Article
- On the rate law and mechanism of the adenosine triphosphate-pyrophosphate isotope exchange reaction of amino acyl transfer ribonucleic acid synthetases Academic Article
- Orthovanadate induces loss of muscarinic cholinergic binding sites Academic Article
- Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide Academic Article
- Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding Academic Article
- P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice Academic Article
- P38 map kinase substrate specificity differs greatly for protein and peptide substrates Academic Article
- PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity Academic Article
- Parallel biomolecular computation on surfaces with advanced finite automata Academic Article
- Pas-a domain of phosphorelay sensor kinase a: A catalytic atp-binding domain involved in the initiation of development in bacillus subtilis Academic Article
- Pathway engineered enzymatic de novo purine nucleotide synthesis Academic Article
- Pathways of nucleoprotein assembly on 5S-RNA genes in a Xenopus oocyte S-150 extract Academic Article
- Phage-display evolution of tyrosine kinases with altered nucleotide specificity Academic Article
- Phosphatidylglycerol directs binding and inhibitory action of EIIAGlc protein on the maltose transporter Academic Article
- Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro Academic Article
- Polynucleotide ligase from myeloid and lymphoid tissues Academic Article
- Polypeptide sequences essential for RNA recognition by an enzyme Academic Article
- Polyphosphoinositide synthesis in human neutrophils - effects of a low metabolic energy state Academic Article
- Possible steps of complete disassembly of post-termination complex by yeast eef3 deduced from inhibition by translocation inhibitors Academic Article
- Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy Academic Article
- Predicting the conformational variability of Abl tyrosine kinase using molecular dynamics simulations and Markov state models Academic Article
- Preparation of metal-chelate complexes and the design of steady-state kinetic experiments involving metal nucleotide complexes Academic Article
- Preparation of semiintact cells for study of vesicular trafficking in-vitro Academic Article
- Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry Academic Article
- Probing adenylation: Using a fluorescently labelled atp probe to directly label and immunoprecipitate vops substrates Academic Article
- Profiling protein kinases and other ATP binding proteins in Arabidopsis using Acyl-ATP probes Academic Article
- Programmable and autonomous computing machine made of biomolecules Academic Article
- Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes Academic Article
- Protein conformation ensembles monitored by HDX reveal a structural rationale for abscisic acid signaling protein affinities and activities Academic Article
- Proton nuclear magnetic resonance and electron paramagnetic resonance studies on skeletal muscle actin indicate that the metal and nucleotide binding sites are separate Academic Article
- Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase Academic Article
- RNA-Dependent cysteine biosynthesis in archaea Academic Article
- RNA-dependent cysteine biosynthesis in archaea Academic Article
- Rab-alpha GDI activity is regulated by a Hsp90 chaperone complex Academic Article
- Rapid deacylation by isoleucyl transfer ribonucleic acid synthetase of isoleucine-specific transfer ribonucleic acid aminoacylated with valine Academic Article
- Recent advances of MEK inhibitors and their clinical progress Academic Article
- Recognition templates for predicting adenylate-binding sites in proteins Academic Article
- Recruitment of epidermal growth-factor and transferrin receptors into coated pits in-vitro - differing biochemical requirements Academic Article
- Regulation of Shaker K+ channel inactivation gating by the cAMP-dependent protein kinase Academic Article
- Release of aminoacyl transfer ribonucleic acid from transfer ribonucleic acid synthetase studied by rapid molecular sieve chromatography Academic Article
- Removal of impurities from transcription factor preparations that alter their DNA-binding properties Academic Article
- Requirement for binding multiple ATPs to convert a GroEL ring to the folding-active state Academic Article
- Reversible activation of non-steroid binding oestrogen receptor Academic Article
- Role for adenosine-triphosphate in regulating the assembly and transport of vesicular stomatitis-virus g protein trimers Academic Article
- Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome Academic Article
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- Selective ATP-competitive inhibitors of TOR suppress rapamycin-insensitive function of TORC2 in Saccharomyces cerevisiae Academic Article
- Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk Academic Article
- Semi-intact cells permeable to macromolecules - use in reconstitution of protein-transport from the endoplasmic-reticulum to the golgi-complex Academic Article
- Sequential action of MalE and maltose allows coupling ATP hydrolysis to translocation in the MalFGK(2) transporter Academic Article
- Sequential intermediates in the pathway of intercompartmental transport in a cell-free system Academic Article
- Sequential intermediates in the transport of protein between the endoplasmic-reticulum and the golgi Academic Article
- Serum suppresses myeloid progenitor apoptosis by regulating iron homeostasis Academic Article
- Sh3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation Academic Article
- Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation Academic Article
- Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts Academic Article
- Small terminase couples viral DNA binding to genome-packaging ATPase activity Academic Article
- Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein Academic Article
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- Spectinomycin kinase from legionella pneumophila - characterization of substrate specificity and identification of catalytically important residues Academic Article
- Stage-specific assays for coated pit formation and coated vesicle budding in vitro Academic Article
- Structural analysis of the RSC chromatin-remodeling complex Academic Article
- Structural and chemical requirements for histidine phosphorylation by the chemotaxis kinase CheA Academic Article
- Structural basis for specific inhibition of tRNA synthetase by an ATP competitive inhibitor Academic Article
- Structural consequences of effector binding to the t-state of aspartate carbamoyltransferase - crystal-structures of the unligated and atp-complexed and ctp-complexed enzymes at 2.6-a resolution Academic Article
- Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B Academic Article
- Structure and functional role of dynein's microtubule-binding domain Academic Article
- Structure and mechanism of the ruvb holliday junction branch migration motor Academic Article
- Structure and regulatory mechanism of Aquifex aeolicus NtrC4: variability and evolution in bacterial transcriptional regulation Academic Article
- Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding Academic Article
- Structure of the actin-myosin complex and its implications for muscle-contraction Academic Article
- Structure of the pilus assembly protein TadZ from eubacterium rectale: Implications for polar localization Academic Article
- Structures of tryptophanyl-tRNA synthetase II from Deinococcus radiodurans bound to ATP and tryptophan. Insight into subunit cooperativity and domain motions linked to catalysis Academic Article
- Studies on norepinephrine-containing afferents to purkinje cells of rat cerebellum. 3. Evidence for mediation of norepinephrine effects by cyclic 3',5'-adenosine monophosphate Academic Article
- Studies on the mechanism of oxidative-phosphorylation - effects of specific f-0 modifiers on ligand-induced conformation changes of f1 Academic Article
- Substituting c-jun n-terminal kinase-3 (jnk3) atp-binding site amino acid residues with their p38 counterparts affects binding of jnk- and p38-selective inhibitors Academic Article
- Substrate binding-affinity changes in mitochondrial energy-linked reactions Academic Article
- Substrate recognition and selection by the initiation module PheATE of gramicidin S synthetase Academic Article
- Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90 Academic Article
- Suppressors of superoxide production from mitochondrial complex III Academic Article
- Synergistic kinetic interactions between components of the phosphorelay controlling sporulation in bacillus subtilis Academic Article
- Synthesis and activity of new aryl- and heteroaryl- substituted pyrazole inhibitors of the transforming growth factor-βtype I receptor kinase domain Academic Article
- Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors Academic Article
- Synthesis of a resorcylic acid lactone (RAL) library using fluorous-mixture synthesis and profile of its selectivity against a panel of kinases Academic Article
- Synthetic peptides of the effector-binding domain of rab enhance secretion from digitonin-permeabilized chromaffin cells Academic Article
- TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP Academic Article
- The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits Academic Article
- The action of cardiolipin on the bacterial translocon Academic Article
- The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1 beta under acidic extracellular pH in LPS-primed microglial cells Academic Article
- The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes Academic Article
- The crystal structures of chloramphenicol phosphotransferase reveal a novel inactivation mechanism Academic Article
- The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism Academic Article
- The design and synthesis of novel alpha-ketoamide-based p38 map kinase inhibitors Academic Article
- The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines Academic Article
- The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme Academic Article
- The influence of nitric oxide on soluble guanylate cyclase regulation by nucleotides: Role of the pseudosymmetric site Academic Article
- The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas Academic Article
- The maltose ABC transporter: Action of membrane lipids on the transporter stability, coupling and ATPase activity Academic Article
- The mechanism of receptor-mediated endocytosis - more questions than answers Academic Article
- The molecular principles governing the activity and functional diversity of AAA plus proteins Academic Article
- The motor protein myosin-i produces its working stroke in two steps Academic Article
- The neurohormone orexin stimulates hypoxia-inducible factor-1 activity Academic Article
- The properties of Msh2-Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair Academic Article
- The protective effects of nucleotides on the histamine hypersensitivity of Bordetella pertussis-treated mice Academic Article
- The rad50 signature motif: Essential to atp binding and biological function Academic Article
- The role of protein-protein interactions in the assembly of the presynaptic filament for t4 homologous recombination Academic Article
- The role of the kinesin-13 neck in microtubule depolymerization Academic Article
- The role of the proteasomal ATPases and activator monoubiquitylation in regulating Gal4 binding to promoters Academic Article
- The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type iiptrases Academic Article
- The structure of jnk3 in complex with small molecule inhibitors: Structural basis for potency and selectivity Academic Article
- The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux Academic Article
- The thermotoga maritima trk potassium transporter-from frameshift to function Academic Article
- The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA Academic Article
- The way things move: Looking under the hood of molecular motor proteins Academic Article
- The ydaO motif is an ATP-sensing riboswitch in Bacillus subtilis Academic Article
- Tissue factor prothrombotic activity is regulated by integrin-arf6 trafficking Academic Article
- Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, atp, and gtp Academic Article
- TorsinA and torsion dystonia: unraveling the architecture of the nuclear envelope Academic Article
- Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis Academic Article
- Transfer ribonucleic acid synthetase catalyzed deacylation of aminoacyl transfer ribonucleic acid in the absence of adenosine monophosphate and pyrophosphate Academic Article
- Tumor regression by targeted gene delivery to the neovasculature Academic Article
- Two classes give lessons about CCA Academic Article
- Two classes of binding sites for uncoating protein in clathrin triskelions Academic Article
- Two classes of tRNA synthetases suggested by sterically compatible dockings on tRNA acceptor stem Academic Article
- Two distinct mechanisms for the initiation of mast cell degranulation Academic Article
- Unique interactions of asialo von Willebrand factor with platelets in platelet-type von Willebrand disease Academic Article
- Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib Academic Article
- Use of a semisynthetic epitope to probe histidine kinase activity and regulation Academic Article
- Variations in the in vivo P-31 MR spectra of the developing human brain during postnatal life. Work in progress Academic Article
- Xol-1, primary determinant of sexual fate in c. Elegans, is a ghmp kinase family member and a structural prototype for a class of developmental regulators Academic Article
- Xpb and xpd helicases in tfiih orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via cak kinase Academic Article
- YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress Academic Article