subject area of
- 2-deoxy-2-iodo- and 2-deoxy-2-bromo-alpha-glucopyranosyl trichloroacetimidates: highly reactive and stereoselective donors for the synthesis of 2-deoxy-beta-glycosides Academic Article
- A concise and flexible synthesis of the potent anti-influenza agents tamiflu and tamiphosphor Academic Article
- A fluoroacetamidine-based inactivator of protein arginine deiminase 4: Design, synthesis, and in vitro and in vivo evaluation Academic Article
- A straightforward alpha-selective aromatic glycosylation and its application for stereospecific synthesis of 4-methylumbelliferyl alpha-T-antigen Academic Article
- Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1 Academic Article
- Chemical modulation of cell surfaces by sulfhydryl compounds: Effect on c3b receptors Academic Article
- Cytomegalovirus causes a latent infection in undifferentiated cells and is activated by induction of cell-differentiation Academic Article
- Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics Academic Article
- Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics Academic Article
- Design, synthesis and evaluation of a PLG tripeptidomimetic based on a pyridine scaffold Academic Article
- Development of oseltamivir phosphonate congeners as anti-influenza agents Academic Article
- Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice Academic Article
- Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model Academic Article
- Discovering disease-associated enzymes by proteome reactivity profiling Academic Article
- Discovery of N-(benzo 1,2,3 triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding Academic Article
- Discovery of selective RIO2 kinase small molecule ligand Academic Article
- Discovery, synthesis, and structure-based optimization of a series of n-(tert-butyl)-2-(n-arylamido)-2-(pyridin-3-yl) acetamides (ml188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (sars-cov) 3cl protease Academic Article
- Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice Academic Article
- Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity Academic Article
- Inhibition of choline acetyltransferase from bovine caudate nucleus by sulfhydryl reagents and reactivation of the inhibited enzyme Academic Article
- Isolation and functional-characterization of the active light chain of activated human-blood coagulation factor-XI Academic Article
- Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates Academic Article
- Mechanisms of linezolid resistance among coagulase-negative staphylococci determined by whole-genome sequencing Academic Article
- Metal-switching and self-inclusion of functional cavitands Academic Article
- Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066) Academic Article
- O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors Academic Article
- Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response Academic Article
- Photochemical activities of N-nitroso carboxamides and sulfoximides and their application to DNA cleavage Academic Article
- Potent antagonists of the Kv1.5 potassium channel: synthesis and evaluation of analogous N,N-diisopropyl-2-(pyridine-3-yl)acetamides Academic Article
- Primary amides. A general nitrogen source for catalytic asymmetric aminohydroxylation of olefins Academic Article
- Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases Academic Article
- Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain Academic Article
- Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors Academic Article
- Structure-activity relationships in the binding of chemically derivatized cd4 to gp120 from human immunodeficiency virus Academic Article
- Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors Academic Article
- Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes Academic Article
- The effect in vivo and in vitro of allylisopropylacetamide on the content of hepatic microsomal cytochrome P-450 2 of phenobarbital treated rabbits Academic Article
- Total synthesis of an immunomodulatory phosphoglycolipid from thermophilic bacteria Academic Article
- Total synthesis of thiopeptide antibiotics ge2270a, ge2270t, and ge2270c1 Academic Article