subject area of

• 2-deoxy-2-iodo- and 2-deoxy-2-bromo-alpha-glucopyranosyl trichloroacetimidates: highly reactive and stereoselective donors for the synthesis of 2-deoxy-beta-glycosides  Academic Article
• A concise and flexible synthesis of the potent anti-influenza agents tamiflu and tamiphosphor  Academic Article
• A fluoroacetamidine-based inactivator of protein arginine deiminase 4: Design, synthesis, and in vitro and in vivo evaluation  Academic Article
• A straightforward alpha-selective aromatic glycosylation and its application for stereospecific synthesis of 4-methylumbelliferyl alpha-T-antigen  Academic Article
• Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1  Academic Article
• Chemical modulation of cell surfaces by sulfhydryl compounds: Effect on c3b receptors  Academic Article
• Cytomegalovirus causes a latent infection in undifferentiated cells and is activated by induction of cell-differentiation  Academic Article
• Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics  Academic Article
• Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics  Academic Article
• Design, synthesis and evaluation of a PLG tripeptidomimetic based on a pyridine scaffold  Academic Article
• Development of oseltamivir phosphonate congeners as anti-influenza agents  Academic Article
• Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice  Academic Article
• Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model  Academic Article
• Discovering disease-associated enzymes by proteome reactivity profiling  Academic Article
• Discovery of N-(benzo 1,2,3 triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding  Academic Article
• Discovery of selective RIO2 kinase small molecule ligand  Academic Article
• Discovery, synthesis, and structure-based optimization of a series of n-(tert-butyl)-2-(n-arylamido)-2-(pyridin-3-yl) acetamides (ml188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (sars-cov) 3cl protease  Academic Article
• Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice  Academic Article
• Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity  Academic Article
• Inhibition of choline acetyltransferase from bovine caudate nucleus by sulfhydryl reagents and reactivation of the inhibited enzyme  Academic Article
• Isolation and functional-characterization of the active light chain of activated human-blood coagulation factor-XI  Academic Article
• Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates  Academic Article
• Mechanisms of linezolid resistance among coagulase-negative staphylococci determined by whole-genome sequencing  Academic Article
• Metal-switching and self-inclusion of functional cavitands  Academic Article
• Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)  Academic Article
• O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors  Academic Article
• Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response  Academic Article
• Photochemical activities of N-nitroso carboxamides and sulfoximides and their application to DNA cleavage  Academic Article
• Potent antagonists of the Kv1.5 potassium channel: synthesis and evaluation of analogous N,N-diisopropyl-2-(pyridine-3-yl)acetamides  Academic Article
• Primary amides. A general nitrogen source for catalytic asymmetric aminohydroxylation of olefins  Academic Article
• Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases  Academic Article
• Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain  Academic Article
• Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors  Academic Article
• Structure-activity relationships in the binding of chemically derivatized cd4 to gp120 from human immunodeficiency virus  Academic Article
• Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors  Academic Article
• Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes  Academic Article
• The effect in vivo and in vitro of allylisopropylacetamide on the content of hepatic microsomal cytochrome P-450 2 of phenobarbital treated rabbits  Academic Article
• Total synthesis of an immunomodulatory phosphoglycolipid from thermophilic bacteria  Academic Article
• Total synthesis of thiopeptide antibiotics ge2270a, ge2270t, and ge2270c1  Academic Article