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Protein Domains

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  • A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV  Academic Article
  • A hingeless Fc fusion system for site-specific cleavage by IdeS  Academic Article
  • A small single-domain protein folds through the same pathway on and off the ribosome  Academic Article
  • An online resource for GPCR structure determination and analysis  Academic Article
  • Bacterial energy sensor Aer modulates the activity of the chemotaxis kinase CheA based on the redox state of the flavin cofactor  Academic Article
  • Broad neutralization of SARS-related viruses by human monoclonal antibodies  Academic Article
  • Ca (2+)-induced rigidity change of the myosin VIIa IQ motif-single α helix lever arm extension  Academic Article
  • Chemical tools for studying the impact of cis/trans prolyl isomerization on signaling: a case study on RNA polymerase II phosphatase activity and specificity  Academic Article
  • Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome  Academic Article
  • Crystal structure of the Frizzled 4 receptor in a ligand-free state  Academic Article
  • ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia  Academic Article
  • Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1  Academic Article
  • GNE-371, a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like  Academic Article
  • GNE-781, a highly advanced potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein, binding protein (CBP)  Academic Article
  • Gating mechanisms of acid-sensing ion channels  Academic Article
  • Genetic identification of the functional surface for RNA binding by Escherichia coli ProQ  Academic Article
  • Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes  Academic Article
  • Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators  Academic Article
  • Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations  Academic Article
  • Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model  Academic Article
  • KDM2B recruitment of the polycomb group complex, PRC1.1, requires cooperation between PCGF1 and BCORL1  Academic Article
  • Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp UW4: A potential step between subgroups in the tautomerase superfamily  Academic Article
  • Lactose binding induces opposing dynamics changes in human galectins revealed by NMR-based hydrogen-deuterium exchange  Academic Article
  • Ligand activation of ERRα by cholesterol mediates statin and bisphosphonate effects  Academic Article
  • Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape  Academic Article
  • Malleable folding of coiled-coils regulates kinesin-3 dimerization  Academic Article
  • Manipulating protein-protein interactions in nonribosomal peptide synthetase type II peptidyl carrier proteins  Academic Article
  • Mapping the phosphorylation pattern of Drosophila melanogaster RNA polymerase II carboxyl-terminal domain using ultraviolet photodissociation mass spectrometry  Academic Article
  • Mechanism of NMDA receptor inhibition and activation  Academic Article
  • Mechanism of Ska recruitment by Ndc8 complexes to kinetochores  Academic Article
  • Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase  Academic Article
  • Mechanisms for zinc and proton inhibition of the GluN1/GluN2A NMDA receptor  Academic Article
  • Modulation of HIF-2α PAS-B domain contributes to physiological responses  Academic Article
  • Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd  Academic Article
  • Optimized arylomycins are a new class of Gram-negative antibiotics  Academic Article
  • Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing, and interaction with the LDL receptor  Academic Article
  • Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability  Academic Article
  • Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice  Academic Article
  • Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma  Academic Article
  • Redox-based reagents for chemoselective methionine bioconjugation  Academic Article
  • Self-reporting chemically induced protein proximity system based on a malachite green derivative and the L5** fluorogen activating protein  Academic Article
  • Stability and conformation of a chemoreceptor HAMP domain chimera correlates with signaling properties  Academic Article
  • Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein  Academic Article
  • Structural and mechanistic bases for a potent HIV-1 capsid inhibitor  Academic Article
  • Structural aspects of small-molecule inhibition of methyllysine reader proteins  Academic Article
  • Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain  Academic Article
  • Structural basis for interaction of the tandem zinc finger domains of human muscleblind with cognate RNA from human cardiac troponin T  Academic Article
  • Structural basis of IMP3 RRM12 recognition of RNA  Academic Article
  • Structural basis of a shared antibody response to SARS-CoV-2  Academic Article
  • Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase  Academic Article
  • Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab  Academic Article
  • Structure of the frequency-interacting RNA helicase: a protein interaction hub for the circadian clock  Academic Article
  • Structure of the human TRPM4 ion channel in a lipid nanodisc  Academic Article
  • Structure of the human epithelial sodium channel by cryo-electron microscopy  Academic Article
  • The E-2.65 A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors  Academic Article
  • The crystal structure of the Helicobacter pylori LlaJI.R1 N-terminal domain provides a model for site-specific DNA binding  Academic Article
  • Transcription control by the ENL YEATS domain in acute leukaemia  Academic Article

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