subject area of
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- A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV Academic Article
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- A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding Academic Article
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- An APEX2 proximity ligation method for mapping interactions with the nuclear lamina Academic Article
- An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain Academic Article
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- Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody Academic Article
- Broad neutralization of SARS-related viruses by human monoclonal antibodies Academic Article
- Ca (2+)-induced rigidity change of the myosin VIIa IQ motif-single α helix lever arm extension Academic Article
- Chemical tools for studying the impact of cis/trans prolyl isomerization on signaling: a case study on RNA polymerase II phosphatase activity and specificity Academic Article
- Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome Academic Article
- Crystal structure of the Frizzled 4 receptor in a ligand-free state Academic Article
- ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia Academic Article
- Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2 Academic Article
- Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1 Academic Article
- Functional importance of the D614G mutation in the SARS-CoV-2 spike protein Academic Article
- GNE-371, a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like Academic Article
- GNE-781, a highly advanced potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein, binding protein (CBP) Academic Article
- Gating mechanisms of acid-sensing ion channels Academic Article
- Genetic identification of the functional surface for RNA binding by Escherichia coli ProQ Academic Article
- Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes Academic Article
- HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells Academic Article
- Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators Academic Article
- Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations Academic Article
- Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model Academic Article
- KDM2B recruitment of the polycomb group complex, PRC1.1, requires cooperation between PCGF1 and BCORL1 Academic Article
- Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp UW4: A potential step between subgroups in the tautomerase superfamily Academic Article
- Lactose binding induces opposing dynamics changes in human galectins revealed by NMR-based hydrogen-deuterium exchange Academic Article
- Ligand activation of ERRα by cholesterol mediates statin and bisphosphonate effects Academic Article
- Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape Academic Article
- Malleable folding of coiled-coils regulates kinesin-3 dimerization Academic Article
- Manipulating protein-protein interactions in nonribosomal peptide synthetase type II peptidyl carrier proteins Academic Article
- Mapping the phosphorylation pattern of Drosophila melanogaster RNA polymerase II carboxyl-terminal domain using ultraviolet photodissociation mass spectrometry Academic Article
- Mechanism of NMDA receptor inhibition and activation Academic Article
- Mechanism of Ska recruitment by Ndc8 complexes to kinetochores Academic Article
- Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase Academic Article
- Mechanisms for zinc and proton inhibition of the GluN1/GluN2A NMDA receptor Academic Article
- Modulation of HIF-2α PAS-B domain contributes to physiological responses Academic Article
- Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd Academic Article
- Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6 Academic Article
- Optimized arylomycins are a new class of Gram-negative antibiotics Academic Article
- Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing, and interaction with the LDL receptor Academic Article
- Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses Academic Article
- Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability Academic Article
- Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice Academic Article
- Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies Academic Article
- Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma Academic Article
- Redox-based reagents for chemoselective methionine bioconjugation Academic Article
- SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 Academic Article
- Self-reporting chemically induced protein proximity system based on a malachite green derivative and the L5** fluorogen activating protein Academic Article
- Stability and conformation of a chemoreceptor HAMP domain chimera correlates with signaling properties Academic Article
- Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein Academic Article
- Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate Academic Article
- Structural and mechanistic bases for a potent HIV-1 capsid inhibitor Academic Article
- Structural aspects of small-molecule inhibition of methyllysine reader proteins Academic Article
- Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain Academic Article
- Structural basis for interaction of the tandem zinc finger domains of human muscleblind with cognate RNA from human cardiac troponin T Academic Article
- Structural basis of IMP3 RRM12 recognition of RNA Academic Article
- Structural basis of a shared antibody response to SARS-CoV-2 Academic Article
- Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase Academic Article
- Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab Academic Article
- Structure of the frequency-interacting RNA helicase: a protein interaction hub for the circadian clock Academic Article
- Structure of the human TRPM4 ion channel in a lipid nanodisc Academic Article
- Structure of the human epithelial sodium channel by cryo-electron microscopy Academic Article
- Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape Academic Article
- The E-2.65 A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors Academic Article
- The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein Academic Article
- The crystal structure of the Helicobacter pylori LlaJI.R1 N-terminal domain provides a model for site-specific DNA binding Academic Article
- Transcription control by the ENL YEATS domain in acute leukaemia Academic Article