subject area of

• A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity  Academic Article
• A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV  Academic Article
• A hingeless Fc fusion system for site-specific cleavage by IdeS  Academic Article
• A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding  Academic Article
• A small single-domain protein folds through the same pathway on and off the ribosome  Academic Article
• An APEX2 proximity ligation method for mapping interactions with the nuclear lamina  Academic Article
• An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain  Academic Article
• An Engineered Arginine Residue of Unusual pH-Sensitive Reactivity Facilitates Site-Selective Antibody Conjugation  Academic Article
• An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines  Academic Article
• An online resource for GPCR structure determination and analysis  Academic Article
• Bacterial energy sensor Aer modulates the activity of the chemotaxis kinase CheA based on the redox state of the flavin cofactor  Academic Article
• Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody  Academic Article
• Broad neutralization of SARS-related viruses by human monoclonal antibodies  Academic Article
• Ca (2+)-induced rigidity change of the myosin VIIa IQ motif-single α helix lever arm extension  Academic Article
• Chemical tools for studying the impact of cis/trans prolyl isomerization on signaling: a case study on RNA polymerase II phosphatase activity and specificity  Academic Article
• Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome  Academic Article
• Crystal structure of the Frizzled 4 receptor in a ligand-free state  Academic Article
• Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design  Academic Article
• Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2  Academic Article
• ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia  Academic Article
• Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2  Academic Article
• Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1  Academic Article
• Functional importance of the D614G mutation in the SARS-CoV-2 spike protein  Academic Article
• GNE-371, a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like  Academic Article
• GNE-781, a highly advanced potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein, binding protein (CBP)  Academic Article
• Gating mechanisms of acid-sensing ion channels  Academic Article
• Genetic identification of the functional surface for RNA binding by Escherichia coli ProQ  Academic Article
• Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes  Academic Article
• HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells  Academic Article
• Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2 in humans and mice  Academic Article
• Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators  Academic Article
• Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations  Academic Article
• Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model  Academic Article
• KDM2B recruitment of the polycomb group complex, PRC1.1, requires cooperation between PCGF1 and BCORL1  Academic Article
• Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp UW4: A potential step between subgroups in the tautomerase superfamily  Academic Article
• Lactose binding induces opposing dynamics changes in human galectins revealed by NMR-based hydrogen-deuterium exchange  Academic Article
• Ligand activation of ERRα by cholesterol mediates statin and bisphosphonate effects  Academic Article
• Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape  Academic Article
• Malleable folding of coiled-coils regulates kinesin-3 dimerization  Academic Article
• Manipulating protein-protein interactions in nonribosomal peptide synthetase type II peptidyl carrier proteins  Academic Article
• Mapping the phosphorylation pattern of Drosophila melanogaster RNA polymerase II carboxyl-terminal domain using ultraviolet photodissociation mass spectrometry  Academic Article
• Mechanism of NMDA receptor inhibition and activation  Academic Article
• Mechanism of Ska recruitment by Ndc8 complexes to kinetochores  Academic Article
• Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase  Academic Article
• Mechanisms for zinc and proton inhibition of the GluN1/GluN2A NMDA receptor  Academic Article
• Modulation of HIF-2α PAS-B domain contributes to physiological responses  Academic Article
• Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd  Academic Article
• Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6  Academic Article
• Murine Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Neutralize Authentic Wild-Type SARS-CoV-2 as Well as B.1.1.7 and B.1.351 Viruses and Protect In Vivo in a Mouse Model in a Neutralization-Dependent Manner  Academic Article
• NMR Based SARS-CoV-2 Antibody Screening  Academic Article
• Optimized arylomycins are a new class of Gram-negative antibiotics  Academic Article
• Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing, and interaction with the LDL receptor  Academic Article
• Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses  Academic Article
• Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability  Academic Article
• Predicting the efficacy of COVID-19 convalescent plasma donor units with the Lumit Dx anti-receptor binding domain assay  Academic Article
• Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice  Academic Article
• Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies  Academic Article
• Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma  Academic Article
• Redox-based reagents for chemoselective methionine bioconjugation  Academic Article
• SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2  Academic Article
• Self-reporting chemically induced protein proximity system based on a malachite green derivative and the L5** fluorogen activating protein  Academic Article
• Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines  Academic Article
• Stability and conformation of a chemoreceptor HAMP domain chimera correlates with signaling properties  Academic Article
• Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein  Academic Article
• Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate  Academic Article
• Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants  Academic Article
• Structural and mechanistic bases for a potent HIV-1 capsid inhibitor  Academic Article
• Structural aspects of small-molecule inhibition of methyllysine reader proteins  Academic Article
• Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain  Academic Article
• Structural basis for interaction of the tandem zinc finger domains of human muscleblind with cognate RNA from human cardiac troponin T  Academic Article
• Structural basis of IMP3 RRM12 recognition of RNA  Academic Article
• Structural basis of a shared antibody response to SARS-CoV-2  Academic Article
• Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase  Academic Article
• Structure of an AMPK complex in an inactive, ATP-bound state  Academic Article
• Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab  Academic Article
• Structure of the frequency-interacting RNA helicase: a protein interaction hub for the circadian clock  Academic Article
• Structure of the human TRPM4 ion channel in a lipid nanodisc  Academic Article
• Structure of the human epithelial sodium channel by cryo-electron microscopy  Academic Article
• Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape  Academic Article
• Structures of the human LONP1 protease reveal regulatory steps involved in protease activation  Academic Article
• Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors  Academic Article
• The E-2.65 A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors  Academic Article
• The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein  Academic Article
• The crystal structure of the Helicobacter pylori LlaJI.R1 N-terminal domain provides a model for site-specific DNA binding  Academic Article
• Transcription control by the ENL YEATS domain in acute leukaemia  Academic Article