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Fingolimod Hydrochloride

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  • A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya)  Academic Article
  • A regenerative approach to the treatment of multiple sclerosis  Academic Article
  • Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists  Academic Article
  • Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools  Academic Article
  • Egress: A receptor-regulated step in lymphocyte trafficking  Academic Article
  • Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues  Academic Article
  • Exogenous S1P exposure potentiates ischemic stroke damage that is reduced possibly by inhibiting S1P receptor signaling  Academic Article
  • FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation  Academic Article
  • FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination  Academic Article
  • Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy  Academic Article
  • Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes  Academic Article
  • Immunomodulator FTY720 induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3  Academic Article
  • Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling  Academic Article
  • Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics  Academic Article
  • Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis  Academic Article
  • Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis  Academic Article
  • Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis  Academic Article
  • Potent s1p receptor agonists replicate the pharmacologic actions of the novel immune modulator fty720  Academic Article
  • Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury  Academic Article
  • ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo  Academic Article
  • Roles for lysophospholipid S1P receptors in multiple sclerosis  Academic Article
  • S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis  Academic Article
  • Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate  Academic Article
  • Sphingosine 1-phosphate pathway therapeutics: A lipid ligand-receptor paradigm  Academic Article
  • Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice  Academic Article
  • Sphingosine 1-phosphate receptor agonists: A patent review (2010 - 2012)  Academic Article
  • Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: the role of sphingosine 1-phosphate receptor-4  Academic Article
  • Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated cd4(+) t cells  Academic Article
  • Sphingosine-1-phosphate receptor antagonism enhances proliferation and migration of engrafted neural progenitor cells in a model of viral-induced demyelination  Academic Article
  • Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor  Academic Article
  • Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent fty720  Academic Article
  • T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow  Academic Article
  • The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen  Academic Article
  • The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators  Academic Article
  • The sources of a lipid conundrum  Academic Article
  • Tipping the gatekeeper: S1p regulation of endothelial barrier function  Academic Article
  • Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection  Academic Article
  • Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia  Academic Article

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