subject area of
- A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya) Academic Article
- A regenerative approach to the treatment of multiple sclerosis Academic Article
- Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists Academic Article
- Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools Academic Article
- Egress: A receptor-regulated step in lymphocyte trafficking Academic Article
- Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues Academic Article
- Exogenous S1P exposure potentiates ischemic stroke damage that is reduced possibly by inhibiting S1P receptor signaling Academic Article
- FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation Academic Article
- FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination Academic Article
- Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy Academic Article
- Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes Academic Article
- Immunomodulator FTY720 induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3 Academic Article
- Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling Academic Article
- Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics Academic Article
- Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis Academic Article
- Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis Academic Article
- Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis Academic Article
- Potent s1p receptor agonists replicate the pharmacologic actions of the novel immune modulator fty720 Academic Article
- Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury Academic Article
- ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo Academic Article
- Roles for lysophospholipid S1P receptors in multiple sclerosis Academic Article
- S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis Academic Article
- Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate Academic Article
- Sphingosine 1-phosphate pathway therapeutics: A lipid ligand-receptor paradigm Academic Article
- Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice Academic Article
- Sphingosine 1-phosphate receptor agonists: A patent review (2010 - 2012) Academic Article
- Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: the role of sphingosine 1-phosphate receptor-4 Academic Article
- Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated cd4(+) t cells Academic Article
- Sphingosine-1-phosphate receptor antagonism enhances proliferation and migration of engrafted neural progenitor cells in a model of viral-induced demyelination Academic Article
- Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor Academic Article
- Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent fty720 Academic Article
- T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow Academic Article
- The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen Academic Article
- The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators Academic Article
- The sources of a lipid conundrum Academic Article
- Tipping the gatekeeper: S1p regulation of endothelial barrier function Academic Article
- Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection Academic Article
- Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia Academic Article