Guo, Min

Person

Positions

2014 - 2016 Associate Professor, Cancer Biology , Scripps Research
2014 - 2016 Associate Professor (Joint Appointment), Cell and Molecular Biology (CMB) , Scripps Research
2010 - 2016 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
2013 - 2014 Assistant Professor (Joint Appointment), Cell and Molecular Biology (CMB) , Scripps Research
2010 - 2014 Assistant Professor, Cancer Biology , Scripps Research

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recent publications

academic article
- Kong, J., Fang, P., Madoux, F., Spicer, T. P., Scampavia, L., Kim, S., Guo, M. High-throughput screening for protein synthesis inhibitors targeting aminoacyl-tRNA synthetases SLAS Discovery 2018 23:174-182 DOI:10.1177/2472555217734128 PMID:29020503
- Motzik, A., Amir, E., Erlich, T., Wang, J., Kim, B. G., Han, J. M., Kim, J. H., Nechushtan, H., Guo, M., Razin, E., Tshori, S. Post-translational modification of HINT1 mediates activation of MITF transcriptional activity in human melanoma cells Oncogene 2017 36:4732-4738 DOI:10.1038/onc.2017.81 PMID:28394346
- Wang, J., Fang, P. F., Chase, P., Tshori, S., Razin, E., Spicer, T. P., Scampavia, L., Hodder, P., Guo, M. Development of an HTS-compatible assay for discovery of melanoma-related microphthalmia transcription factor disruptors using AlphaScreen technology SLAS Discovery 2017 22:58-66 DOI:10.1177/1087057116675274 PMID:27827304
- Kim, D. G., Lee, J. Y., Lee, J. H., Cho, H. Y., Kang, B. S., Jang, S. Y., Kim, M. H., Guo, M., Han, J. M., Kim, S. J., Kim, S. Oncogenic mutation of AIMP2/p38 inhibits its tumor-suppressive interaction with Smurf2 Cancer Research 2016 76:3422-3436 DOI:10.1158/0008-5472.can-15-3255 PMID:27197155
- Cho, H. Y., Maeng, S. J., Cho, H. J., Choi, Y. S., Chung, J. M., Lee, S., Kim, H. K., Kim, J. H., Eom, C. Y., Kim, Y. G., Guo, M., Jung, H. S., et al. Assembly of multi-tRNA synthetase complex via heterotetrameric glutathione transferase-homology domains Journal of Biological Chemistry 2015 290:29313-29328 DOI:10.1074/jbc.M115.690867 PMID:26472928 PMCID:PMC4705937
- Schaub, F. X., Reza, M. S., Flaveny, C. A., Li, W., Musicant, A. M., Hoxha, S., Guo, M., Cleveland, J. L., Amelio, A. L. Fluorophore-NanoLuc BRET reporters enable sensitive in vivo optical imaging and flow cytometry for monitoring tumorigenesis Cancer Research 2015 75:5023-5033 DOI:10.1158/0008-5472.can-14-3538 PMID:26424696 PMCID:PMC4668208
- Rachmin, I., Amsalem, E., Golomb, E., Beeri, R., Gilon, D., Fang, P., Nechushtan, H., Kay, G., Guo, M., Yiqing, P. L., Foo, R. S. Y., Fisher, D. E., et al. FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy International Journal of Cardiology 2015 195:85-94 DOI:10.1016/j.ijcard.2015.05.108 PMID:26025865 PMCID:PMC4478144
- Mirando, A. C., Fang, P., Williams, T. F., Baldor, L. C., Howe, A. K., Ebert, A. M., Wilkinson, B., Lounsbury, K. M., Guo, M., Francklyn, C. S. Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor Scientific Reports 2015 5:13160 DOI:10.1038/srep13160 PMID:26271225 PMCID:PMC4536658
- Park, H., Gonzalez, A. L., Yildirim, I., Tran, T., Lohman, J. R., Fang, P., Guo, M., Disney, M. D. Crystallographic and computational analyses of AUUCU repeating RNA that causes spinocerebellar ataxia type 10 (SCA10) Biochemistry 2015 54:3851-3859 DOI:10.1021/acs.biochem.5b00551 PMID:26039897 PMCID:PMC4876817
- Fang, P., Han, H., Wang, J., Chen, K., Chen, X., Guo, M. Structural basis for specific inhibition of tRNA synthetase by an ATP competitive inhibitor Chemistry & Biology 2015 22:734-744 DOI:10.1016/j.chembiol.2015.05.007 PMID:26074468 PMCID:PMC4503318
- Fang, P., Guo, M. The nature's clever trick for making cyclic dinucleotide Structure 2015 23:801-802 DOI:10.1016/j.str.2015.04.011 PMID:25955098
- Slade, D. J., Fang, P., Dreyton, C. J., Zhang, Y., Fuhrmann, J., Rempel, D., Bax, B. D., Coonrod, S. A., Lewis, H. D., Guo, M., Gross, M. L., Thompson, P. R. Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design ACS Chemical Biology 2015 10:1043-1053 DOI:10.1021/cb500933j PMID:25621824 PMCID:PMC4569063
- Fang, P., Yu, X., Jeong, S. J., Mirando, A., Chen, K., Chen, X., Kim, S., Francklyn, C. S., Guo, M. Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase Nature Communications 2015 6:6402 DOI:10.1038/ncomms7402 PMID:25824639 PMCID:PMC4389257
- Lo, W. S., Gardiner, E., Xu, Z., Lau, C. F., Wang, F., Zhou, J. J., Mendlein, J. D., Nangle, L. A., Chiang, K. P., Yang, X. L., Au, K. F., Wong, W. H., et al. Human tRNA synthetase catalytic nulls with diverse functions Science 2014 345:328-332 DOI:10.1126/science.1252943 PMID:25035493 PMCID:PMC4188629
- Naganuma, M., Sekine, S., Chong, Y. E., Guo, M., Yang, X. L., Gamper, H., Hou, Y. M., Schimmel, P., Yokoyama, S. The selective tRNA aminoacylation mechanism based on a single G.U pair Nature 2014 510:507-511 DOI:10.1038/nature13440 PMID:24919148 PMCID:PMC4323281
- Guo, M., Yang, X. L. Architecture and metamorphosis Topics in Current Chemistry 2014 344:89-118 DOI:10.1007/128_2013_424 PMID:23536245 PMCID:PMC3864538
- Kim, D. G., Lee, J. Y., Kwon, N. H., Fang, P., Zhang, Q., Wang, J., Young, N. L., Guo, M., Cho, H. Y., Mushtaq, A. U., Jeon, Y. H., Choi, J. W., et al. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction Nature Chemical Biology 2014 10:29-34 DOI:10.1038/nchembio.1381 PMID:24212136 PMCID:PMC4021855
- Gonzalez, M., McLaughlin, H., Houlden, H., Guo, M., Yo-Tsen, L., Hadjivassilious, M., Speziani, F., Yang, X. L., Antonellis, A., Reilly, M. M., Zuchner, S., Inherited Neuropathy Consortium (INC) Exome sequencing identifies a significant variant in methionyl-tRNA synthetase (MARS) in a family with late-onset CMT2 Journal of Neurology Neurosurgery and Psychiatry 2013 84:1247-1249 DOI:10.1136/jnnp-2013-305049 PMID:23729695 PMCID:PMC3796032
- Guo, M., Schimmel, P. Essential nontranslational functions of tRNA synthetases Nature Chemical Biology 2013 9:145-153 DOI:10.1038/nchembio.1158 PMID:23416400 PMCID:PMC3773598
- Ofir-Birin, Y., Fang, P. F., Bennett, S. P., Zhang, H. M., Wang, J., Rachmin, I., Shapiro, R., Song, J., Dagan, A., Pozo, J., Kim, S., Marshall, A. G., et al. Structural switch of lysyl-tRNA synthetase between translation and transcription Molecular Cell 2013 49:30-42 DOI:10.1016/j.molcel.2012.10.010 PMID:23159739 PMCID:PMC3766370
- Guo, M., Schimmel, P. Homeostatic mechanisms by alternative forms of tRNA synthetases Trends in Biochemical Sciences 2012 37:401-403 DOI:10.1016/j.tibs.2012.07.003 PMID:22858252 PMCID:PMC3459177
- Wang, J., Fang, P. F., Schimmel, P., Guo, M. Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor Journal of Physical Chemistry B 2012 116:6798-6805 DOI:10.1021/jp212457w PMID:22329685 PMCID:PMC3375047
- Sajish, M., Zhou, Q. S., Kishi, S., Valdez, D. M., Kapoor, M., Guo, M., Lee, S., Kim, S., Yang, X. L., Schimmel, P. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling Nature Chemical Biology 2012 8:547-554 DOI:10.1038/nchembio.937 PMID:22504299 PMCID:PMC3780985
- Park, M. C., Kang, T., Jin, D., Han, J. M., Kim, S. B., Park, Y. J., Cho, K., Park, Y. W., Guo, M., He, W., Yang, X. L., Schimmel, P., et al. Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis Proceedings of the National Academy of Sciences of the United States of America 2012 109:E640-E647 DOI:10.1073/pnas.1200194109 PMID:22345558 PMCID:PMC3306665
- Guo, M., Schimmel, P. Structural analyses clarify the complex control of mistranslation by tRNA synthetases Current Opinion in Structural Biology 2012 22:119-126 DOI:10.1016/j.sbi.2011.11.008 PMID:22155179 PMCID:PMC3288634
- Xu, X. L., Shi, Y., Zhang, H. M., Swindell, E. C., Marshall, A. G., Guo, M., Kishi, S., Yang, X. L. Unique domain appended to vertebrate tRNA synthetase is essential for vascular development Nature Communications 2012 3:681 DOI:10.1038/ncomms1686 PMID:22353712 PMCID:PMC3293412
- Jones, J. E., Slack, J. L., Fang, P. F., Zhang, X. S., Subramanian, V., Causey, C. P., Coonrod, S. A., Guo, M., Thompson, P. R. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors ACS Chemical Biology 2012 7:160-165 DOI:10.1021/cb200258q PMID:22004374 PMCID:PMC3262960
- Kumar, A., Park, H., Fang, P. F., Parkesh, R., Guo, M., Nettles, K. W., Disney, M. D. Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 x 1 nucleotide UU internal loop conformations Biochemistry 2011 50:9928-9935 DOI:10.1021/bi2013068 PMID:21988728 PMCID:PMC3218087
- Kumar, A., Fang, P. F., Park, H., Guo, M., Nettles, K. W., Disney, M. D. A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome ChemBioChem 2011 12:2140-2142 DOI:10.1002/cbic.201100337 PMID:21766409 PMCID:PMC3379549
- He, W., Zhang, H. M., Chong, Y. E., Guo, M., Marshall, A. G., Yang, X. L. Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening Proceedings of the National Academy of Sciences of the United States of America 2011 108:12307-12312 DOI:10.1073/pnas.1104293108 PMID:21737751 PMCID:PMC3145702
- Fang, P. F., Zhang, H. M., Shapiro, R., Marshall, A. G., Schimmel, P., Yang, X. L., Guo, M. Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex Proceedings of the National Academy of Sciences of the United States of America 2011 108:8239-8244 DOI:10.1073/pnas.1100224108 PMID:21536907 PMCID:PMC3100937
- Guo, M., Shapiro, R., Morris, G. M., Yang, X. L., Schimmel, P. Packaging HIV virion components through dynamic equilibria of a human tRNA synthetase Journal of Physical Chemistry B 2010 114:16273-16279 DOI:10.1021/jp1082517 PMID:21058683 PMCID:PMC3042951
- Guo, M., Yang, X. L., Schimmel, P. New functions of aminoacyl-tRNA synthetases beyond translation Nature Reviews Molecular Cell Biology 2010 11:668-674 DOI:10.1038/nrm2956 PMID:20700144 PMCID:PMC3042954
- Guo, M., Shapiro, R., Schimmel, P., Yang, X. L. Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase Acta Crystallographica Section D-Biological Crystallography 2010 66:243-250 DOI:10.1107/s0907444909055462 PMID:20179335 PMCID:PMC2827346
- Guo, M., Schimmel, P., Yang, X. L. Functional expansion of human tRNA synthetases achieved by structural inventions FEBS Letters 2010 584:434-442 DOI:10.1016/j.febslet.2009.11.064 PMID:19932696 PMCID:PMC2826164
- Zhou, Q. S., Kapoor, M., Guo, M., Belani, R., Xu, X. L., Kiosses, W. B., Hanan, M., Park, C., Armour, E., Do, M. H., Nangle, L. A., Schimmel, P., et al. Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality Nature Structural & Molecular Biology 2010 17:57-61 DOI:10.1038/nsmb.1706 PMID:20010843 PMCID:PMC3042952
- Guo, M., Chong, Y. E., Shapiro, R., Beebe, K., Yang, X. L., Schimmel, P. Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma Nature 2009 462:808-812 DOI:10.1038/nature08612 PMID:20010690 PMCID:PMC2799227
- Guo, R. T., Chong, Y. E., Guo, M., Yang, X. L. Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis Journal of Biological Chemistry 2009 284:28968-28976 DOI:10.1074/jbc.M109.030692 PMID:19710017 PMCID:PMC2781443
- Fang, P. F., Wang, J., Li, X., Guo, M., Xing, L., Cao, X., Zhu, Y., Gao, Y., Niu, L. W., Teng, M. K. Crystallization and preliminary x-ray analysis of escherichia coli RNase G Acta Crystallographica Section F-Structural Biology and Crystallization Communications 2009 65:586-588 DOI:10.1107/s1744309109015802 PMID:19478437 PMCID:PMC2688416
- Schimmel, P., Guo, M. A tipping point for mistranslation and disease Nature Structural & Molecular Biology 2009 16:348-349 DOI:10.1038/nsmb0409-348 PMID:19343067
- Schimmel, P., Guo, M. Ancient tRNA synthetase meets modern structural biology Structure 2009 17:315-317 DOI:10.1016/j.str.2009.02.002 PMID:19278642
- Guo, M., Chong, Y. E., Beebe, K., Shapiro, R., Yang, X. L., Schimmel, P. The C-Ala domain brings together editing and aminoacylation functions on one tRNA Science 2009 325:744-747 DOI:10.1126/science.1174343 PMID:19661429 PMCID:PMC4559334
- Guo, M., Xu, F., Yamada, J., Egelhofer, T., Gao, Y. X., Hartzog, G. A., Teng, M. K., Niu, L. W. Core structure of the yeast spt4-spt5 complex: A conserved module for regulation of transcription elongation Structure 2008 16:1649-1658 DOI:10.1016/j.str.2008.08.013 PMID:19000817 PMCID:PMC2743916
- Guo, M., Ignatov, M., Musier-Forsyth, K., Schimmel, P., Yang, X. L. Crystal structure of tetrameric form of human lysyl-tRNA synthetase: implications for multisynthetase complex formation Proceedings of the National Academy of Sciences of the United States of America 2008 105:2331-2336 DOI:10.1073/pnas.0712072105 PMID:18272479 PMCID:PMC2268136
- Beebe, K., Waas, W., Druzina, Z., Guo, M., Schimmel, P. A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities Analytical Biochemistry 2007 368:111-121 DOI:10.1016/j.ab.2007.05.013 PMID:17603003 PMCID:PMC3833075
- Yang, X. L., Guo, M., Kapoor, M., Ewalt, K. L., Otero, F. J., Skene, R. J., McRee, D. E., Schimmel, P. Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase Structure 2007 15:793-805 DOI:10.1016/j.str.2007.05.009 PMID:17637340 PMCID:PMC2104486
- Li, X. W., Guo, M., Fan, J., Tang, W. Y., Wang, D. Q., Ge, H. H., Rong, H., Teng, M. K., Niu, L. W., Liu, Q., Hao, Q. Crystal structure of 3-hydroxyanthranilic acid 3,4-dioxygenase from saccharomyces cerevisiae: A special subgroup of the type III extradiol dioxygenases Protein Science 2006 15:761-773 DOI:10.1110/ps.051967906 PMID:16522801 PMCID:PMC2242480
- Fan, J., Wang, D. Q., Liang, Z., Guo, M., Teng, M. K., Niu, L. W. Maize uroporphyrinogen III methyltransferase: Overexpression of the functional gene fragments in escherichia coli and one-step purification Protein Expression and Purification 2006 46:40-46 DOI:10.1016/j.pep.2005.07.010 PMID:16289918
- Wang, J., Guo, M., Lou, X. H., Duan, Y. Y., Cheng, X. P., Teng, M. K., Niu, L. W., Liu, Q., Huang, Q. Q., Hao, Q., Shen, B. Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from naja atra venom that targets the BKCa channel Biochemistry 2005 44:10145-10152 DOI:10.1021/bi050614m PMID:16042391
- Wang, D. Q., Guo, M., Liang, Z., Fan, J., Zhu, Z. Q., Zhu, Z. G., Li, X. W., Zang, J. Y., Teng, M. K., Niu, L. W., Dong, Y. H. Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites Journal of Biological Chemistry 2005 280:22962-22967 DOI:10.1074/jbc.M500464200 PMID:15788412
- Guo, M., Teng, M. K., Niu, L. W., Liu, Q., Huang, Q. Q., Hao, Q. Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a k(+) channel inhibitor-like fold Journal of Biological Chemistry 2005 280:12405-12412 DOI:10.1074/jbc.M413566200 PMID:15596436
- Wang, J., Guo, M., Tu, X. Y., Zheng, D. H., Teng, M. K., Niu, L. W., Liu, Q., Huang, Q. Q., Hao, Q. Purification, partial characterization, crystallization and preliminary X-ray diffraction of two cysteine-rich secretory proteins from naja atra and trimeresurus stejnegeri venoms Acta Crystallographica Section D-Biological Crystallography 2004 60:1108-1111 DOI:10.1107/s0907444904005670 PMID:15159571

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