recent publications

• academic article

  • Gay, S. C., Zhang, H. M., Wilderman, P. R., Roberts, A. G., Liu, T., Li, S., Lin, H. L., Zhang, Q. H., Woods, V. L., Stout, C. D., Hollenberg, P. F., Halpert, J. R. Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity Biochemistry  2011 50:4903-4911  DOI:10.1021/bi200482g  PMID:21510666  PMCID:PMC3105221
  • Wilderman, P. R., Shah, M. B., Liu, T., Li, S., Hsu, S., Roberts, A. G., Goodlett, D. R., Zhang, Q. H., Woods, V. L., Stout, C. D., Halpert, J. R. Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography Journal of Biological Chemistry  2010 285:38602-38611  DOI:10.1074/jbc.M110.180646  PMID:20880847  PMCID:PMC2992292
  • Gay, S. C., Roberts, A. G., Maekawa, K., Talakad, J. C., Hong, W. X., Zhang, Q. H., Stout, C. D., Halpert, J. R. Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel Biochemistry  2010 49:8709-8720  DOI:10.1021/bi100914z  PMID:20815363  PMCID:PMC3005796
  • Gay, S. C., Shah, M. B., Talakad, J. C., Maekawa, K., Roberts, A. G., Wilderman, P. R., Sun, L., Yang, J. Y., Huelga, S. C., Hong, W. X., Zhang, Q. H., Stout, C. D., et al. Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution Molecular Pharmacology  2010 77:529-538  DOI:10.1124/mol.109.062570  PMID:20061448  PMCID:PMC2845937
  • Cameron, M. D., Wen, B., Roberts, A. G., Atkins, W. M., Campbell, A. P., Nelson, S. D. Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site Chemical Research in Toxicology  2007 20:1434-1441  DOI:10.1021/tx7000702  PMID:17894464
  • Cameron, M. D., Wen, B., Allen, K. E., Roberts, A. G., Schuman, J. T., Campbell, A. P., Kunze, K. L., Nelson, S. D. Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study Biochemistry  2005 44:14143-14151  DOI:10.1021/bi051689t  PMID:16245930