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Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones

Academic Article
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Overview

authors

  • Kravchenko, Vladimir
  • Garner, A. L.
  • Mathison, J.
  • Seit-Nebi, A.
  • Yu, J.
  • Gileva, I. P.
  • Ulevitch, Richard
  • Janda, Kim

publication date

  • June 2013

journal

  • ACS Chemical Biology  Journal

abstract

  • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in cancer cells over normal cells; however, tumor cells may develop TRAIL resistance. Here, we demonstrate that this resistance can be overcome in the presence of bacterial acylhomoserine lactones (AHLs) or AHL-producing bacteria through the combined effect of TRAIL-induced apoptosis and AHL-mediated inhibition of inflammation regulated by NF-κB signaling. This discovery unveils a previously unrecognized symbiotic link between bacteria and host immunosurveillance.

subject areas

  • Acyl-Butyrolactones
  • Apoptosis
  • Cell Line, Tumor
  • Cytokines
  • Humans
  • NF-kappa B
  • Neoplasms
  • Pseudomonas aeruginosa
  • Signal Transduction
  • TNF-Related Apoptosis-Inducing Ligand
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Identity

PubMed Central ID

  • PMC3755046

International Standard Serial Number (ISSN)

  • 1554-8937 (Electronic) 1554-8929 (Linking)

Digital Object Identifier (DOI)

  • 10.1021/cb4000184

PubMed ID

  • 23517377
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Additional Document Info

start page

  • 1117

end page

  • 1120

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