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Influenza A virus neuraminidase limits viral superinfection

Academic Article
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Overview

authors

  • Huang, I. C.
  • Li, W. H.
  • Sui, J. H.
  • Marasco, W.
  • Choe, Hyeryun
  • Farzan, Michael

publication date

  • May 2008

journal

  • Journal of Virology  Journal

abstract

  • Enveloped viruses use multiple mechanisms to inhibit infection of a target cell by more than one virion. These mechanisms may be of particular importance for the evolution of segmented viruses, because superinfection exclusion may limit the frequency of reassortment of viral genes. Here, we show that cellular expression of influenza A virus neuraminidase (NA), but not hemagglutinin (HA) or the M2 proton pump, inhibits entry of HA-pseudotyped retroviruses. Cells infected with H1N1 or H3N2 influenza A virus were similarly refractory to HA-mediated infection and to superinfection with a second influenza A virus. Both HA-mediated entry and viral superinfection were rescued by the neuraminidase inhibitors oseltamivir carboxylate and zanamivir. These inhibitors also prevented the removal of alpha-2,3- and alpha-2,6-linked sialic acid observed in cells expressing NA or infected with influenza A viruses. Our data indicate that NA alone among viral proteins limits influenza A virus superinfection.

subject areas

  • Animals
  • Antiviral Agents
  • Cell Line
  • Dogs
  • Hemagglutinins
  • Humans
  • Influenza A Virus, H1N1 Subtype
  • Influenza A Virus, H3N2 Subtype
  • Neuraminidase
  • Oseltamivir
  • Viral Interference
  • Viral Matrix Proteins
  • Viral Proteins
  • Zanamivir
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Identity

PubMed Central ID

  • PMC2346733

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.00079-08

PubMed ID

  • 18321971
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Additional Document Info

start page

  • 4834

end page

  • 4843

volume

  • 82

issue

  • 10

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