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Autoantigen ku in the brain. Developmentally regulated expression and subcellular localization

Academic Article
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Overview

authors

  • Bakalkin, G.
  • Yakovleva, T.
  • Hurd, Y. L.
  • Nussenzweig, A.
  • Li, G. C.
  • Terenius, Lars

publication date

  • June 1998

journal

  • Neuroreport  Journal

abstract

  • A double-stranded DNA end-binding factor with high levels of expression in brain and testis of adult mice was identified as the Ku protein, earlier described as an autoantigen in connective tissue diseases and found to be essential for recombination of the immunoglobulin genes and DNA repair. High Ku levels were found in the cerebellum and pituitary gland, lower levels in the hippocampus, hypothalamus and white matter structures. Ku levels were much higher in embryonic rat brain than in the adult brain, suggesting a role of the Ku protein in brain development. In embryonic rat brain, Ku was associated with cell nuclei, but was predominantly located in the cytosol in the adult rat cerebellum and hippocampus. The abundant expression of Ku in the brain suggests the involvement of Ku autoantibodies in the pathogenesis of neuropsychiatric complications in connective tissue diseases.

subject areas

  • Animals
  • Antigens, Nuclear
  • Autoantigens
  • Blotting, Western
  • Brain Chemistry
  • DNA Helicases
  • DNA Repair
  • DNA-Binding Proteins
  • Gene Expression Regulation, Developmental
  • Mice
  • Mice, Inbred Strains
  • Nuclear Proteins
  • Oligonucleotides
  • Rats
  • Rats, Sprague-Dawley
  • Spermidine
  • Subcellular Fractions
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Research

keywords

  • DNA repair
  • Ku protein
  • autoimmunity
  • brain
  • neuropsychiatric lupus
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Identity

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-199806220-00044

PubMed ID

  • 9674610
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Additional Document Info

start page

  • 2147

end page

  • 2151

volume

  • 9

issue

  • 9

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