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In vivo accumulation of t cells in response to il-2/anti-il-2 mab complexes is dependent in part on the tnf family ligand 4-1bbl

Academic Article
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Overview

authors

  • Lin, G. H. Y.
  • Stone, J. C.
  • Surh, Charles
  • Watts, T. H.

publication date

  • August 2012

journal

  • Immunology and Cell Biology  Journal

abstract

  • Immune complexes combining IL-2 with particular anti-IL-2 antibodies can be used to selectively expand regulatory T cells or memory T cells. Combining IL-2 with anti-IL-2 (Clone S4B6) greatly enhances the biological potency of IL-2 in vivo leading to selective expansion of CD8 memory T cells and NK cells compared with regulatory T cells. Here we show that in vivo administration of IL-2/anti-IL-2 mAb (IL-2/mAb) complexes induces 4-1BB expression on both adoptively transferred antigen-specific memory CD8 T cells as well as on endogenous memory phenotype cells. Remarkably, the accumulation of adoptively transferred memory CD8 T cells following in vivo IL-2/mAb-complex treatment was found to be dependent in part on the presence of 4-1BBL in the host. These effects were independent of IL-2-induced cell division, suggesting that 4-1BBL-induced survival signals contribute to IL-2/mAb-complex-induced T-cell accumulation in vivo.

subject areas

  • 4-1BB Ligand
  • Adoptive Transfer
  • Animals
  • Antibodies, Monoclonal
  • Antigens, CD137
  • CD8-Positive T-Lymphocytes
  • Cell Proliferation
  • Cell Survival
  • Flow Cytometry
  • Immunologic Memory
  • Interleukin-2
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
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Research

keywords

  • 4-1BBL
  • CD137
  • IL-2-antibody complex
  • T cell
  • therapy
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Identity

PubMed Central ID

  • PMC3415591

International Standard Serial Number (ISSN)

  • 0818-9641

Digital Object Identifier (DOI)

  • 10.1038/icb.2011.83

PubMed ID

  • 21946662
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Additional Document Info

start page

  • 743

end page

  • 747

volume

  • 90

issue

  • 7

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