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Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death

Academic Article
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Overview

authors

  • Subramaniam, Srinivasa
  • Unsicker, K.

publication date

  • 2006

journal

  • Neuroscience  Journal

abstract

  • Extracellular signal-regulated kinase (ERK) is a versatile protein kinase, which has been implicated in signaling numerous biological functions ranging from embryonic development to memory formation. Recent reports, including ours, indicate that ERK plays a central role in promoting neuronal degeneration in various neuronal systems including neurodegenerative diseases. Mechanisms involved in ERK-induced neuronal degeneration are beginning to emerge. In this review, we summarize evidence suggesting ERK to be a predominant inducer of a non-apoptotic mode of neuronal death. Further, we discuss the mechanisms and the putative molecular inter-players associated with ERK-mediated neuronal death.

subject areas

  • Animals
  • Autophagy
  • Calcium Signaling
  • Calpain
  • Caspases
  • Cell Death
  • Extracellular Signal-Regulated MAP Kinases
  • Humans
  • Nerve Degeneration
  • Nervous System
  • Neurons
  • Signal Transduction
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Research

keywords

  • ERK
  • autophagy
  • calcium
  • calpains
  • caspase
  • ischemia
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Identity

International Standard Serial Number (ISSN)

  • 0306-4522

Digital Object Identifier (DOI)

  • 10.1016/j.neuroscience.2005.12.013

PubMed ID

  • 16442236
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Additional Document Info

start page

  • 1055

end page

  • 1065

volume

  • 138

issue

  • 4

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