related to degree

• Worrell, Brady, Ph.D. in Chemistry, Scripps Research 2008 - 2014

authors

• Selander, N.
• Worrell, Brady
• Chuprakov, S.
• Velaparthi, S.
• Fokin, Valery

publication date

• 2012

journal

• Journal of the American Chemical Society  Journal

abstract

• A highly efficient and stereoselective arylation of in situ-generated azavinyl carbenes affording 2,2-diaryl enamines at ambient temperatures has been developed. These transition-metal carbenes are directly produced from readily available and stable 1-sulfonyl-1,2,3-triazoles in the presence of a rhodium carboxylate catalyst. In several cases, the enamines generated in this reaction can be cyclized into substituted indoles employing copper catalysis.

subject areas

• Amines
• Aza Compounds
• Boronic Acids
• Catalysis
• Crystallography, X-Ray
• Methane
• Models, Molecular
• Molecular Structure
• Organometallic Compounds
• Rhodium
• Stereoisomerism

PubMed Central ID

• PMC3597238

International Standard Serial Number (ISSN)

• 0002-7863

Digital Object Identifier (DOI)

• 10.1021/ja3062453

PubMed ID

• 22913576

start page

• 14670

end page

• 14673

volume

• 134

issue

• 36