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Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus?

Academic Article
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Overview

authors

  • Sullivan, Brian
  • Welch, M. J.
  • Lemke, G.
  • Oldstone, Michael

publication date

  • April 2013

journal

  • Journal of Virology  Journal

abstract

  • A recent publication indicated that overexpression of Axl, a cellular receptor that negatively regulates Toll-like receptor signaling, enhanced the entry of viruses pseudotyped with the glycoprotein of lymphocytic choriomeningitis virus (LCMV) in vitro. In testing the biological relevance of these observations, we found differences in neither viral kinetics between LCMV infections of Axl(-/-) and wild-type mice nor T-cell responses prior to spontaneous viral clearance. Thus, Axl is not required for productive LCMV infection of mice.

subject areas

  • Animals
  • Arenaviridae Infections
  • Arenavirus
  • Fluorescence
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Proto-Oncogene Proteins
  • Receptor Protein-Tyrosine Kinases
  • Virus Internalization
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Identity

PubMed Central ID

  • PMC3624193

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.03268-12

PubMed ID

  • 23325690
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Additional Document Info

start page

  • 4071

end page

  • 4074

volume

  • 87

issue

  • 7

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