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Ca2+ signaling in cerebellar Purkinje neurons-editorial

Academic Article
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Overview

authors

  • Gruol, Donna
  • Manto, M.
  • Haines, D.

publication date

  • September 2012

journal

  • Cerebellum  Journal

abstract

  • Tight regulation of calcium (Ca(2+)) dynamics is critical for all neurons. Ca(2+) is a major mediator of cellular excitability, synaptic plasticity, and regulation of transcription, amongst others. Recent years have seen major developments in terms of understanding the roles of Ca(2+) signals in the cerebellar circuitry, especially for Purkinje neurons and granule cells. The unique morphology of Purkinje neurons serves as a platform to unravel the secrets of Ca(2+) homeostasis in cerebellar microcircuits. This special issue covers recent advances in Ca(2+) signaling and imaging, and highlights the importance of spatiotemporal compartmentalization underlying Ca(2+) dynamics. Sorting out the pieces of the puzzle of homeostatic regulation of Ca(2+) remains an instrumental step to start rational therapies of Ca(2+) deregulation.

subject areas

  • Action Potentials
  • Animals
  • Calcium Signaling
  • Cerebellar Cortex
  • Cerebellum
  • Humans
  • Models, Neurological
  • Neurons
  • Patch-Clamp Techniques
  • Purkinje Cells
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Research

keywords

  • Calcium
  • Circuits
  • Imaging
  • Purkinje neuron
  • Signaling
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Identity

PubMed Central ID

  • PMC3570272

International Standard Serial Number (ISSN)

  • 1473-4222

Digital Object Identifier (DOI)

  • 10.1007/s12311-012-0404-4

PubMed ID

  • 22806980
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Additional Document Info

start page

  • 605

end page

  • 608

volume

  • 11

issue

  • 3

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