Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Potential application of mesenchymal stem cells in acute lung injury

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Lee, Jiing-Dwan
  • Gupta, Naveen
  • Serikov, V.
  • Matthay, M. A.

publication date

  • October 2009

journal

  • Expert Opinion on Biological Therapy  Journal

abstract

  • Despite extensive research into the pathogenesis of acute lung injury and the acute respiratory distress syndrome (ALI/ARDS), mortality remains high at approximately 40%. Current treatment is primarily supportive, with lung-protective ventilation and a fluid conservative strategy. Pharmacologic therapies that reduce the severity of lung injury in experimental studies have not yet been translated into effective clinical treatment options. Therefore, innovative therapies are needed. Recent studies have suggested that bone-marrow-derived multipotent mesenchymal stem cells (MSC) may have therapeutic applications in multiple clinical disorders including myocardial infarction, diabetes, sepsis, hepatic and acute renal failure. Recently, MSC have been studied in several in vivo models of lung disease. This review focuses on first describing the existing experimental literature that has tested the use of MSC in models of ALI/ARDS, and then the potential mechanisms underlying their therapeutic use with an emphasis on secreted paracrine soluble factors. The review concludes with a discussion of future research directions required for potential clinical trials.

subject areas

  • Acute Lung Injury
  • Animals
  • Humans
  • Mesenchymal Stem Cells
  • Stem Cell Transplantation
scroll to property group menus

Research

keywords

  • Pulmonary edema
  • acute respiratory distress syndrome
  • keratinocyte growth factor
  • mesenchymal stem cells
scroll to property group menus

Identity

PubMed Central ID

  • PMC2852252

International Standard Serial Number (ISSN)

  • 1471-2598

Digital Object Identifier (DOI)

  • 10.1517/14712590903213651

PubMed ID

  • 19691441
scroll to property group menus

Additional Document Info

start page

  • 1259

end page

  • 1270

volume

  • 9

issue

  • 10

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support