Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Abraham, J.
  • Corbett, K. D.
  • Farzan, Michael
  • Choe, Hyeryun
  • Harrison, S. C.

publication date

  • April 2010

journal

  • Nature Structural & Molecular Biology  Journal

abstract

  • New World hemorrhagic fever arenaviruses are rodent-borne agents that cause severe human disease. The GP1 subunit of the surface glycoprotein mediates cell attachment through transferrin receptor 1 (TfR1). We report the structure of Machupo virus (MACV) GP1 bound with human TfR1. Atomic details of the GP1-TfR1 interface clarify the importance of TfR1 residues implicated in New World arenavirus host specificity. Analysis of sequence variation among New World arenavirus GP1s and their host-species receptors, in light of the molecular structure, indicates determinants of viral zoonotic transmission. Infectivities of pseudoviruses in cells expressing mutated TfR1 confirm that contacts at the tip of the TfR1 apical domain determine the capacity of human TfR1 to mediate infection by particular New World arenaviruses. We propose that New World arenaviruses that are pathogenic to humans fortuitously acquired affinity for human TfR1 during adaptation to TfR1 of their natural hosts.

subject areas

  • Antigens, CD
  • Arenaviruses, New World
  • Glycoproteins
  • Humans
  • Protein Conformation
  • Receptors, Transferrin
  • Receptors, Virus
  • Viral Proteins
scroll to property group menus

Identity

PubMed Central ID

  • PMC2920743

International Standard Serial Number (ISSN)

  • 1545-9985

Digital Object Identifier (DOI)

  • 10.1038/nsmb.1772

PubMed ID

  • 20208545
scroll to property group menus

Additional Document Info

start page

  • 438

end page

  • 44

volume

  • 17

issue

  • 4

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support