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Relative abundance of alzheimer a-beta amyloid peptide variants in alzheimer-disease and normal aging

Academic Article
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Overview

authors

  • Naslund, J.
  • Schierhorn, A.
  • Hellman, U.
  • Lannfelt, L.
  • Roses, A. D.
  • Tjernberg, L. O.
  • Silberring, J.
  • Gandy, S. E.
  • Winblad, B.
  • Greengard, P.
  • Nordstedt, C.
  • Terenius, Lars

publication date

  • August 1994

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • The Alzheimer A beta amyloid peptide (A beta) is the principal proteinaceous component of amyloid associated with Alzheimer disease (AD). We have determined the relative abundance of A beta structural variants present in amyloid from brains of 10 individuals with sporadic AD, 2 individuals with familial AD carrying specific mutations in the Alzheimer amyloid precursor protein gene, and 5 nondemented elderly controls. A procedure of isolation based on the extreme insolubility of A beta amyloid was used. The purified, nondigested A beta was analyzed by N-terminal sequencing and electrospray-ionization mass spectrometry. Three principal A beta variants were detected--A beta-(1-40), A beta-(1-42), and A beta-(11-42)--in all brains analyzed. The predominant variant in sporadic AD was A beta-(1-40), whereas the principal A beta variant in nondemented elderly controls was A beta-(1-42). The ratio A beta-(1-40)/A beta-(1-42) differed by 10-fold between brains from nondemented controls and those with sporadic AD.

subject areas

  • Aged
  • Aging
  • Alzheimer Disease
  • Amino Acid Sequence
  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Cerebral Cortex
  • Female
  • Humans
  • Male
  • Mass Spectrometry
  • Molecular Sequence Data
  • Mutation
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.91.18.8378

PubMed ID

  • 8078890
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Additional Document Info

start page

  • 8378

end page

  • 8382

volume

  • 91

issue

  • 18

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